gb & biliary tree
DESCRIPTION
GB & BILIARY TREE. Begashaw M (MD). Gall bladder. pear shaped organ of 7.5 – 12.5 cm length & capacity of 50cc Parts- Fundus,Body & Neck cystic duct - joins GB with common hepatic duct to form CBD. Functions. - Reservoir for bile - Organ for concentrating the bile - PowerPoint PPT PresentationTRANSCRIPT
GB & BILIARY TREE
Begashaw M (MD)
Gall bladder
pear shaped organ of 7.5 – 12.5 cm length & capacity of 50cc
Parts-Fundus,Body & Neckcystic duct - joins GB with common
hepatic duct to form CBD
Functions
- Reservoir for bile- Organ for concentrating the bile- Secretion of the mucus
Cholelithiasis
• most common pathology of biliary tree
Classification
1- Cholesterol stone (6%)-usually solitary2- Mixed stone (90%)-cholesterol is the major
component with others like calcium bilirubinate -multiple, faceted & associated with infection3- Pigment stone: composed of calcium
bilirubinate -usually small, multiple & black -associated with hemolytic disease
Risk factors Age > 40 yrs Female sex Obesity Rapid weight loss
– Very low calorie diet – Surgical therapy of
morbid obesity Pregnancy
Fat Fertile Flatulent Female Fifty
Pathogenesis
1- Metabolic:bile formed is supersaturated or lithogenic
2- Infection: increased mucus plug formation & scarring /nidus
3- Stasis: Progesterone in multiparous women is believed to be contributory
Clinical Presentation
Most-90%Asymptomatic Hx- RUQ colicky pain- Dyspepsia, fatty food intolerance, flatulence,
abnormal postprandial bloating P/E-RUQ tenderness-Risk factors - identified
Complications
Gall bladder -chronic cholecystitis -acute cholecystitis -gangrene -perforation -empyema -mucocele -carcinoma
Bile duct -obstructive jaundice -cholangitis -acute pancreatitis Intestine -Gall stone ileus
Diagnostic workup
Ultrasounddetects stone in GBPAXR Only 10% of stones are radio opaque Differential diagnosis1. PUD2. Hiatal Hernia3. Carcinoma of stomach4. Diverticular disease5. Angina pectoris
Treatment
Surgery: Open or Laparoscopic1-cholecystectomymain stay of treatment2-cholecystostomy for bad risk patients with
severe infection -Severe Acute cholecystitis -Gall bladder empyema
Acute Cholecystitis
is an acute inflammation of gall bladder due to obstruction of neck of gall bladder or cystic duct stone
In absence of stone Acalculous cholecystitis
Pathogenesis Direct pressure of calculus ischemia, necrosis, and
ulceration with swelling edema & impairment of venous returnFavors bacterial multiplication
End result - Pericholecystic abscess - Fistula formation between gall bladder & bowel - GB empyema/mucocele CommonlyE.coli, Klebsiella , Streptococci,
Enterobacter & Clostridial
Clinical features Hx - chronic cholecystitis /Cholelithiasis - RUQ/epigastric pain radiate to back - Fever/vomiting P/E - RUQ tenderness with rebound tenderness - GB may be palpable - Murphy’s Sign +ve : sudden arrest of inspiration due to
tenderness of inflamed gall bladder which is palpated during deep inspiration
DDX
- Perforated PUD- Biliary colic- Pneumonia- Pancreatitis- Hepatitis
IXns
WBC: Leucocytosis CXR or PAXR: pneumonia/radio opaque
stone Ultrasound: detects calculi, gall bladder
wall thickening & pericholecystic fluid
Treatment
1- conservative- Admit- keep NPO- Start on IV fluid- Insert NGT- Analgesics- Antibiotics - ampicillin & gentamycin - Follow -fever, abd findings/WBC count reduction- cholecystectomy after 6 weeks2. Surgical treatment: Cholecystectomy
OBSTRUCTIVE JAUNDICE
Jaundice is a yellowish discoloration of the sclera, mucous membrane & skin
becomes clinically evident when the level of serum billirubin reaches 2.0 to 3.0 mg/dl
Classification
I Medical:Pre hepatichemolyticHepaticliver problemsII Surgical: obstruction of biliary treeobstructive
jaundice
Biochemical features
Extra hepatic biliary obstruction
Lumen-Gall stone -ParasiticAscaris Wall -Atresia-Stricture-Tumor
Extrinsic-pancreatic head ca-ampullary ca-Pancreatitis-Choledochal cyst
Clinical manifestation
Hx- Intermittent jaundicestone- Progressive jaundice- +/- Pruritis- Urine/stoolclay color- RUQ pain- Loss of appetite/weight loss- History trauma/surgery
P/E- G/Aobesity/emaciation- Depth of jaundice/pallor- Hepatomegaly, splenomegaly- Ascites- Palpable GB- Liver mass- Skin scratch marks
Courvoisier’s Law
If in presence of jaundice, the gall bladder is palpable, then the jaundice is unlikely to be due to stone True in 60%of cases
Investigations
- Hemoglobin-AnemiaMalignancy- U/Abillirubin/urobilinogen- Serum billirubintotal & direct- Serum alk pase- Ultrasoundgall stone, choledochal cyst, dilated
bile duct, Neoplasm- LFT- PT
Treatment Surgery Perioperative-Antibiotic prophylaxis-Parenteral vit K +/- FFP-Fluid resuscitation -careful post operative fluid balance