Fungal Genetics and Biology 65 (2014) 69–80

Contents lists available at ScienceDirect

Fungal Genetics and Biology

journal homepage: www.elsevier .com/locate /yfgbi

Sequencing and functional analysis of the genome of a nematodeegg-parasitic fungus, Pochonia chlamydosporia

http://dx.doi.org/10.1016/j.fgb.2014.02.0021087-1845/� 2014 Elsevier Inc. All rights reserved.

Abbreviations: PHI, pathogen–host interaction; CAZy, carbohydrate-activeenzyme; GH, glycoside hydrolase; CE, carbohydrate esterase; PKS, polyketidesynthase; NRPS, non-ribosomal peptide synthetase; MFS, major facilitator super-family; ABC, ATP-binding cassette; CYP, cytochrome P450; GPCR, G-protein coupledreceptor; PK, protein kinase; HK, histidine kinase; TF, transcription factor.⇑ Corresponding author at: Department of Marine Sciences and Applied Biology,

University of Alicante, P.O. Box. 99, E-03080 Alicante, Spain. Fax: +34 965 909840E-mail addresses: eduardo.larriba@ua.es (E. Larriba), maria.jaime@gmail.com

(M.D.L.A. Jaime), jcarbonell@cipf.es (J. Carbonell-Caballero), aconesa@cipf.es(A. Conesa), jdopazo@cipf.es (J. Dopazo), corey.nislow@gmail.com (C. Nislow),jmnieto@ua.es (J. Martín-Nieto), lv.lopez@ua.es (L.V. Lopez-Llorca).

1 Current address: Department of Pharmaceutical Sciences, University of BritishColumbia, V6T 1Z3 Vancouver, Canada.

Eduardo Larriba a,b, María D.L.A. Jaime c, José Carbonell-Caballero d, Ana Conesa d, Joaquín Dopazo d,Corey Nislow e,f,g,1, José Martín-Nieto b,h, Luis Vicente Lopez-Llorca a,b,⇑a Department of Marine Sciences and Applied Biology, University of Alicante, P.O. Box. 99, E-03080 Alicante, Spainb Multidisciplinary Institute for Environmental Studies (MIES) ‘‘Ramón Margalef’’, University of Alicante, Alicante, Spainc Department of Cell and Systems Biology, University of Toronto, M5S 3G5 Mississauga, Ontario, Canadad Institute for Computational Genomics, Príncipe Felipe Research Center, Avda. Eduardo Primo Yúfera 3, E-46012 Valencia, Spaine Department of Molecular Genetics, University of Toronto, M5S 1A8 Toronto, Ontario, Canadaf Banting and Best Department of Medical Research, University of Toronto, M5S 3E1 Toronto, Ontario, Canadag Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto, M5S 3E1 Toronto, Ontario, Canadah Department of Physiology, Genetics and Microbiology, University of Alicante, E-03080 Alicante, Spain

a r t i c l e i n f o a b s t r a c t

Article history:Received 19 December 2013Accepted 7 February 2014Available online 13 February 2014

Keywords:Pochonia chlamydosporiaGenome sequencingNematophagous fungusEndophyteHydrolytic enzymesGene Ontology

Pochonia chlamydosporia is a worldwide-distributed soil fungus with a great capacity to infect anddestroy the eggs and kill females of plant-parasitic nematodes. Additionally, it has the ability to colonizeendophytically roots of economically-important crop plants, thereby promoting their growth and elicit-ing plant defenses. This multitrophic behavior makes P. chlamydosporia a potentially useful tool for sus-tainable agriculture approaches. We sequenced and assembled �41 Mb of P. chlamydosporia genomicDNA and predicted 12,122 gene models, of which many were homologous to genes of fungal pathogensof invertebrates and fungal plant pathogens. Predicted genes (65%) were functionally annotated accord-ing to Gene Ontology, and 16% of them found to share homology with genes in the Pathogen Host Inter-actions (PHI) database. The genome of this fungus is highly enriched in genes encoding hydrolyticenzymes, such as proteases, glycoside hydrolases and carbohydrate esterases. We used RNA-Seq technol-ogy in order to identify the genes expressed during endophytic behavior of P. chlamydosporia when col-onizing barley roots. Functional annotation of these genes showed that hydrolytic enzymes andtransporters are expressed during endophytism. This structural and functional analysis of the P. chlamy-dosporia genome provides a starting point for understanding the molecular mechanisms involved in themultitrophic lifestyle of this fungus. The genomic information provided here should also prove useful forenhancing the capabilities of this fungus as a biocontrol agent of plant-parasitic nematodes and as a plantgrowth-promoting organism.

� 2014 Elsevier Inc. All rights reserved.

1. Introduction

Plant-parasitic nematodes cause an estimated global loss of US$100 billion annually (Casas-Flores and Herrera-Estrella, 2007).Fungi that parasitize and infect female nematodes and destroytheir eggs include the worldwide-distributed egg-parasitic fungusPochonia chlamydosporia (syn. Verticillium chlamydosporium, teleo-morph Metacordyceps chlamydosporia) (Sung et al., 2007; Zareet al., 2001). P. chlamydosporia is a well known soil fungus (Domschet al., 1993) which infects nematode females and eggs of econom-ically important plant parasitic nematodes (such as Heterodera spp.and Meloidogyne spp.). In some agroecosystems this fungus is amain cause of soil suppressiveness to these nematodes, acting as

70 E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80

their agent of ‘‘natural’’ biological control. Since P. chlamydosporiais not an obligate parasite, it also acts as a true endophyte, coloniz-ing plant roots of diverse species including main crops (such asbarley and tomato). When switching hosts or habitats, this fungusfaces a number of barriers and niches, which requires diverse abil-ities (e.g. protein–glycan degradation), using hydrolases presum-ably encoded in its genome.

Infection of nematode eggs by P. chlamydosporia involves adhe-sion, differentiation of appressoria and egg-shell penetration(Lopez-Llorca et al., 2002b). We have recently documented thedevelopment of penetration hyphae in the Meloidogyne javanicaegg-shell and invasion of egg contents by trophic hyphae using aGFP-tagged P. chlamydosporia strain (Escudero and Lopez-Llorca,2012). However, information on the molecular basis of the infectionprocess of nematode eggs by Pochonia species is scarce. There is evi-dence suggesting that secreted hydrolytic enzymes including prote-ases (Huang et al., 2004; Lopez-Llorca and Robertson, 1992; Mortonet al., 2003) and chitinases (Tikhonov et al., 2002) are fundamentalfor the degradation of egg-shell components. Rosso et al. (2011)used cDNA-amplified fragment length polymorphism (cDNA-AFLP)based on transcript profiling in order to identify genes involved inthe pathogenesis of nematode eggs by P. chlamydosporia, and foundthat genes encoding transcription factors, transporters and en-zymes involved in fungal metabolism are enriched. In particular,expression of the P. chlamydosporia VCP1 serine protease is inducedin response to nitrogen and carbon sources, environmental condi-tions and the presence of nematode eggs (Ward et al., 2012).

Similarly to other Hypocreales (such as Trichoderma spp. andBeauveria bassiana), P. chlamydosporia has a broad host range andcan act as an endophyte in both monocot (Lopez-Llorca et al.,2002a) and dicot (Bordallo et al., 2002) plants. Interestingly, thisfungus promotes plant growth in barley (Hordeum vulgare)(Macia-Vicente et al., 2009b), wheat (Triticum aestivum) (Monfortet al., 2005), tomato (Solanum lycopersicum) (Escudero andLopez-Llorca, 2012), lettuce (Lactuca sativa) (Dias-Arieira et al.,2011) and pistachio (Pistacia vera) (Ebadi et al., 2009). P. chlamydos-poria colonizes the rhizoplane of crop plants, especially cereals,forming abundant chlamydospores (Bordallo et al., 2002; Kerry,2000). This fungus then penetrates root hairs and epidermal cells,and colonizes the cortex but not the root vascular system (Bordalloet al., 2002; Macia-Vicente et al., 2009a). P. chlamydosporiamodulates biochemical (e.g. biosynthesis of secreted phenolic com-pounds) and structural (e.g. root papillae formation) plant defenses(Bordallo et al., 2002; Escudero and Lopez-Llorca, 2012;Macia-Vicente et al., 2009a), but these do not prevent root coloniza-tion by the fungus. P. chlamydosporia expresses proteases during thisprocess, such as VCP1 and SCP1, the latter a newly reported serinecarboxypeptidase (Larriba et al., 2012; Lopez-Llorca et al., 2010).

P. chlamydosporia also produces several polyketide compoundsnamed pochonins (Hellwig et al., 2003), which are resorcylic acidlactones derived from radicicol. Different multifunctional polyke-tide synthases are responsible for carbon skeleton construction,acting at the initial steps in the pochonin biosynthesis pathway(Reeves et al., 2008). Despite the potential of pochonins in biotech-nology and pharmacology (Barluenga et al., 2009), only two genesencoding polyketide synthases from P. chlamydosporia have beencloned and characterized so far (Reeves et al., 2008; Zhou et al.,2010).

The sequencing and functional analysis of genomes recentlyavailable from fungal pathogens of invertebrates (Gao et al.,2011; Zheng et al., 2011) have increased our knowledge on the bio-control capabilities of these organisms. The in-depth functionalgenomic characterization of the nematophagous fungus P. chlamy-dosporia presented in this work provides new insights into themolecular mechanisms enabling its multitrophic lifestyle as a sap-rophyte, nematode pathogen and endophyte.

2. Materials and methods

2.1. Fungal strains

P. chlamydosporia isolate 123 (ATCC number MYA-4875) grownon corn meal agar (CMA) at 25 �C in the dark for 1–4 weeks wasinoculated in four flasks each containing 50 ml of potato dextrosebroth (PDB) and incubated at 25 �C for 8 days with shaking at120 rpm.

2.2. Fungal genome sequencing and assembly

Isolation of genomic DNA was carried out using the DNeasyPlant Mini Kit (Qiagen) according to the manufacturers fungal pro-tocol. Total DNA obtained was subjected to quality control by aga-rose gel electrophoresis and quantified by the same method. Thegenome of P. chlamydosporia was sequenced with MPS (massivelyparallel sequencing) Illumina technology. Two DNA libraries wereconstructed: a pair-end library with an insert size of 200 bp anda mate-pair library with an insert size of 3 kb. Each DNA librarywas sequenced using an Illumina HiSeq 2000 at the DonnellySequencing Centre (University of Toronto). Pair-end and mate-pairsequences were analyzed using the FastQC application (http://www.bioinformatics.bbsrc.ac.uk/projects/fastqc) for quality con-trol. In order to improve the quality of the sequences, IlluminaPCR adapter sequences were removed using the Cutadap tool(Martin, 2011), and sequences were then futher trimmed based onthe Phred quality score (>20) using DynamicTrim (Cox et al.,2010). The genomic trimmed sequences were assembled bySOAPdenovo (http://soap.genomics.org.cn/soapdenovo.html) usingmate-pair reads to generate scaffolds. Transfer RNA (tRNA) geneswere predicted with tRNAscan-SE (Lowe and Eddy, 1997), and gen-ome repetitive sequences were analyzed using RepeatMasker(http://www.repeatmasker.org/). Repetitive elements were identi-fied by RMBlastN search against RepBase v. 20120418 (http://www.girinst.org/repbase). This Whole Genome Shotgun projecthas been deposited at the DDBJ/EMBL/GenBank database underthe accession number AOSW00000000.

2.3. Gene prediction, annotation and protein classification

Ab initio gene prediction was performed on the P. chlamydospo-ria genome assembly by using the Augustus program (Stanke et al.,2006), and as evidence genes of this fungus available in the Gen-Bank database (consulted in June 2013). ESTs from P. chlamydospo-ria (Rosso et al., 2011) and Metarhizium anisopliae (Wang et al.,2005; Zhang and Xia, 2008, 2009), and the training annotation filesfrom Fusarium graminearum were incorporated as references. TheGeneMark-ES program (Ter-Hovhannisyan et al., 2008) was usedas a self-training ab initio predictor. A final set of gene modelswas selected by MAKER2 (Holt and Yandell, 2011) by combiningab initio predictions with transcripts listed above aligned usingExonerate (http://www.ebi.ac.uk/~guy/exonerate). Consensus setsof gene models were functionally annotated using Blast2GO(http://www.blast2go.com/b2ghome). Gene families were estab-lished using the Interpro database (http://www.ebi.ac.uk/interpro),and putatively-secreted proteins were identified using SignaIP(http://www.cbs.dtu.dk/services/SignalP), both implemented inthe Blast2GO suite. Proteases were classified into families bymeans of batch Blast search against the MEROPS database(Rawlings and Morton, 2008). Carbohydrate-active enzymes(CAZymes) were classified by performing a HMMER (http://eddylab.org) scan based on the profiles compiled in dbCAN release 2.0 onthe CAZy database (http://www.cazy.org). To identify potentialpathogenesis genes, a whole genome Blast search (E-value < 10�6)

Table 1Main features of the Pochonia chlamydosporia genome.

Genome size (Mb) 41.2Assembly N50 (kb) 225Coverage (fold) 136G + C content (%) 49.9Repeat rate (%) 0.46Protein-coding genes 12,122Unique proteins 672Secreted proteins 2485Transmembrane proteins 2707Genome coding (%) 42.1Gene density (genes/Mb) 294Average ORF length (kb) 1.4tRNA genes 45Mobile elements 349

E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80 71

was conduced against the Pathogen Host Interactions (PHI) data-base v. 3.2 (http://www.phi-base.org). Secondary metabolismgenes were predicted using SMURF (http://jcvi.org/smurf/index.php).

2.4. Transcriptomic analysis by RNA-Seq

Barley roots were inoculated with P. chlamydosporia as de-scribed in Lopez-Llorca et al. (2010). Isolation of RNA from barleyroots inoculated with the fungus and non-colonized barley rootswas carried out using the RNeasy Plant Mini Kit (Qiagen). Subse-quently, the RNA obtained was amplified using the MessageAmpII kit (Ambion, Life Technologies) according to the manufacturer’sinstructions. Amplified RNA obtained was reverse-transcribed intocDNA and sequenced using a Illumina Genome Analyzer at Macro-gen Inc. (South Korea). Pair-end sequencing yielded 77,606,102reads from control roots and 99,966,600 reads from inoculatedroots, all of them with an average length of 101 bp. All reads werealigned against the genome of P. chlamydosporia using Bowtie(Langmead et al., 2009), and 544,060 reads (0.54% of total) frominoculated plants RNA were found to map with the genome ofP. chlamydosporia. On the contrary, zero reads from control rootsRNA mapped against the fungus genome. To validate the genemodels predicted in the P. chlamydosporia genome, the genes ex-pressed during fungal endophytic colonization of barley roots wereidentified by employing a combination of TopHat (Trapnell et al.,2009) and HTSeq v0.5.4p2 (http://www-huber.embl.de/users/anders/HTSeq) software. These genes were annotated and classi-fied as described in Section 2.3.

2.5. Orthology and phylogenomic analysis

Orthologous gene detection in P. chlamydosporia and 28 addi-tional fungal genomes was carried out using ProteinOrtho (Lechneret al., 2011). In total, 382 orthologous sequences were identified,acquired and aligned using T-Coffee (Notredame et al., 2000).Alignments of orthologous sequences were concatenated usingFASconCAT (Kück and Meusemann, 2010), and a maximum likeli-hood phylogenomic tree was created with the program TREE-PUZ-ZLE using the Dayhoff model (Schmidt et al., 2002). The treeobtained was edited using the TreeGraph 2 software (Stöver andMüller, 2010).

3. Results

3.1. Genome sequencing and general features

P. chlamydosporia strain 123 (ATCC MYA-4875) was found sup-pressing a cereal cyst nematode (Heterodera avenae) population ina field near the city of Seville (SW Spain). The genome of this funguswas sequenced to 136-fold coverage using a whole-genome shot-gun approach and Illumina sequencing technology. The completedassembly (N50, 225 kb) comprised 901 scaffolds and 57 additionalcontigs >3 kb (not assembled into scaffolds) which, after discardingambiguous bases, yielded a final genome size of 41.2 Mb. The mainfeatures of this fungal genome are summarized in Table 1. From thisassembly we predicted a total of 12,122 gene models usingMAKER2 (see Section 2.3), a coding capacity that was similar to thatof other ascomycetes (Table 2). A 63% fraction of these gene modelswas expressed, i.e. validated using RNA-Seq, under endophytism(Supplementary Table 1). A 5.5% (672) of total predicted genes inthe genome did not exhibit any homologous counterparts in theNCBI database (accessed June 2013), of which ca. 41% (277 genes)were expressed during P. chlamydosporia endophytic lifestyle. Pro-tein-coding genes of this fungus showed the highest number of

homologous proteins (34% and 30%, respectively) with theentomopathogenic fungi M. anisopliae and Metarhizium acridum(Table 2).

We built a phylogenomic tree based on P. chlamydosporia gen-ome-encoded orthologous proteins found in the genomes of other28 filamentous fungi and yeasts (Fig. 1). This tree illustrated thatP. chlamydosporia was most closely related to entomopathogenicfungi M. anisopliae and M. acridum. The endophyte Epichloëfestucae, also belonging to the Clavicipitaceae, formed a clade withboth the nematode egg-parasite and the two entomopathogens.Other relevant entomopathogenic fungi (B. bassiana and Cordycepsmilitaris) formed an independent, but closely related clade,whereas mycoparasitic Trichoderma spp. and plant-pathogenicFusarium spp. form adjacent, independent clades (Fig. 1).

3.2. Mobile elements

A 0.46% fraction of the P. chlamydosporia genome consisted ofrepeated sequences, using the RepBase database, we were able toidentify 209 retrotransposons (class I), 133 DNA transposons (classII), and 7 unknown elements (Fig. 2A). The number and family dis-tribution of mobile elements of P. chlamydosporia compared tothose of insect pathogenic fungi are shown in Fig. 2B. This compar-ison showed that the P. chlamydosporia genome exhibited morecopies of most of the 7 families of mobile elements than did theclosely-related insect pathogenic fungi Metarhizium spp.

3.3. Gene Ontology analysis of protein-coding genes

We functionally annotated 7887 protein-coding genes, repre-senting 65% of the P. chlamydosporia whole set of genes in thegenome. The distribution of these genes into functional groupsaccording to Gene Ontology (GO) is shown in Fig. 3. Within theBiological Process GO domain (Fig. 3A), protein-coding genes dis-tributed into the following GO terms: ca. 21% were associated withprimary metabolism, 11% with macromolecule metabolism, suchas protein synthesis and modification, 6% of annotated genes withcatabolism, 9% with biosynthetic processes and 7% with nitrogenmetabolism (Supplementary Fig. 1A). Within the metabolism GOterm, 13% of the annotated genes belonged to the cellular meta-bolic processes GO term (Fig. 3A), whereas 17% of genes wererelated to other cellular processes, such as cell cycle regulation, cellgrowth, cell communication and cell death (SupplementaryFig. 1B). Finally, 2% of genes were related to stress responses, and1% were annotated within interspecies interactions betweenorganisms (Fig. 3A). Within the Molecular Function GO domain(Fig. 3A), we found that 23% of annotated genes encoded proteinsrelated to hydrolase activity, breaking of phosphorus ester bonds,acid anhydrides and peptides, while a further 21% of genes wererelated to transferase activity, including protein kinases

Table 2Genome size, number of predicted protein-coding genes, G + C content and best Blast top hit homology between the genomes of P. chlamydosporia and those of 28 other fungi.

Species Genome size (Mb)a G + C (%)a Number of proteinsa BBTHb Lifestyle NCBI Bioproject

Pochonia chlamydosporia 41.2 49.9 12,122 – Nematophagous PRJNA68669Metarhizium anisopliae 39.0 51.5 10,582 4169 Entomopathogenic PRJNA38717Metarhizium acridum 38.0 49.9 9849 3608 Entomopathogenic PRJNA38715Epichloë festucae 34.7 44.3 9273 871 Endophytic PRJNA42133Fusarium solani 51.2 50.8 15,708 411 Phytopathogenic PRJNA51499Trichoderma virens 39.0 49.2 12,406 386 Mycopathogenic PRJNA19983Fusarium oxysporum 61.4 48.2 15,438 271 Phytopathogenic PRJNA174274Trichoderma atroviride 36.1 49.7 11,816 227 Mycopathogenic PRJNA19867Beauveria bassiana 33.6 51.5 10,364 187 Entomopathogenic PRJNA38719Cordyceps militaris 32.2 51.4 9651 162 Entomopathogenic PRJNA41129Trichoderma reesei 33.3 52.8 9115 140 Mycopathogenic PRJNA15571Aspergillus oryzae 36.5 48.3 11,397 124 Saprophytic PRJNA88495Fusarium graminearum 72.7 48.3 11,628 111 Phytopathogenic PRJNA243Colletotrichum graminicola 50.9 49.1 12,004 99 Phytopathogenic PRJNA37879Aspergillus niger 35.7 50.4 11,182 92 Saprophytic PRJNA19263Verticillium dahliae 32.9 55.8 10,535 86 Phytopathogenic PRJNA28529Colletotrichum higginsianum 44.1 55.1 16,141 83 Phytopathogenic PRJNA47061Botryotinia fuckeliana 39.5 43.5 16,389 72 Phytopathogenic PRJNA20061Aspergillus clavatus 27.8 49.2 9121 62 Saprophytic PRJNA18467Arthrobotrys oligospora 39.9 44.5 11,479 53 Nematophagous PRJNA41495Magnaporthe oryzae 40.9 51.6 12,836 47 Phytopathogenic PRJNA13840Verticillium albo-atrum 30.3 56 10,237 45 Phytopathogenic PRJNA51263Neurospora crassa 39.2 49.3 9841 31 Saprophytic PRJNA132Laccaria bicolor 58.7 47 18,215 10 Mycorrhizal PRJNA29019Piriformospora indica 25.0 50.6 11,791 6 Endophytic PRJEA76339Saccharomyces cerevisiae 12.1 38.2 5905 6 Saprophytic PRJNA128Ustilago maydis 19.9 53.7 6548 5 Phytopathogenic PRJNA14007Schizosaccharomyces pombe 12.5 36 5133 2 Saprophytic PRJNA127Kluyveromyces lactis 10.7 38.7 5076 1 Saprophytic PRJNA13835

a Genome size, G + C content and number of protein-coding genes for each fungus were obtained from the Genome database at NCBI.b BBTH (Best Blast Top Hit) refers to the number of sequences returning the top hit after a BlastP search of 28 fungal genomes.

Fig. 1. Phylogenomic tree of P. chlamydosporia. A maximum likelihood phylogenomic tree was constructed on the basis of 382 concatenated orthologous protein-codinggenes using the Dayhoff amino acid substitution model showing the evolutionary relationships between the indicated 29 fungal species. Bootstrap values are shown inrelevant tree branches.

72 E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80

(Supplementary Fig. 1C). A larger set of genes (43%) were associ-ated with binding of molecules and ions (Supplementary Fig. 1D),with 23% of them being involved in binding to small moleculesand 16% in nucleic-acid binding, and transcription factors repre-senting an additional 2% of annotated genes (Fig. 3A).

3.4. Pathogenesis-related genes

To identify genes involved in pathogenicity in the P. chlamydosporiagenome, we conducted a Blast search against the Pathogen–Host Inter-action (PHI) database, which compiles experimentally-validated

Fig. 2. Mobile elements predicted in the genomes of P. chlamydosporia and otherfungal pathogens of invertebrates. (A) Mobile elements classified into subclassespredicted in the genome and (B) families of mobile elements predicted in thesequenced genomes of fungal pathogens of invertebrates. Class II transposons arerepresented in yellow, class I retrotransposons in blue and unknown elements ingreen. The families of mobile elements in the P. chlamydosporia genome areindicated by brackets. Subclasses and families of mobile elements are indicatedbelow each bar. (For interpretation of the references to color in this figure legend,the reader is referred to the web version of this article.)

E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80 73

pathogenesis-related genes of fungi, bacteria and oomycetes(Winnenburg et al., 2008). We found that 16% of the protein-codinggenes in the genome of P. chlamydosporia (1981 genes) sharedhomology with genes present in the PHI database (SupplementaryFig. 2A), 24% of which (468 genes) coded for putatively secretedpolypeptides. Despite the absence of nematophagous fungi in thisdatabase, we considered experimental validation of pathogenesisfor a gene in a given fungal species as suggestive of a pathogenic rolefor its homolog in other fungi. Using this criterion, virulence geneshave been analyzed in the entomopathogenic fungi M. anisopliaeand M. acridum (Gao et al., 2011). In order to identify the biologicalprocesses and molecular functions attributable to the virulencegenes identified using the PHI database, we carried out a functionalannotation using Blast2GO (Fig. 3B). Genes identified within the Bio-logical Process GO domain fell into 28 functional subcategories,which included genes related to primary metabolism (20%), estab-lishment of localization (15%) and cellular processes (13%). Likewise,

regulation of biological processes (7%), biosynthetic processes (6%)and catabolism (7%) were represented in that domain. Interestingly,of the 81 protein-coding genes identified as associated with the GOterm relationships between organisms, i.e. pathogenesis/symbiosis(Fig. 3A), 47 of them were found in the PHI database (Fig. 3B andSupplementary Fig. 2A). This set of genes included those coding forglycoside hydrolases, proteases, proteins involved in signal trans-duction, detoxification processes and stress response factors(Supplementary Fig. 2B, C and Supplementary Table 2). Within theMolecular Function GO domain (Fig. 3B), we found that nucleo-tide-binding was the most represented GO term (31%), and a largeproportion of the annotated genes to encode proteins having hydro-lase activity (14%), transferase activity (16%) or nucleic acid-bindingproperties (12%), with an additional 3% being related to transcrip-tion factors (Fig. 3B).

3.5. Transcriptomic analysis of root endophytic colonization

In order to identify protein-coding genes involved in P. chlamy-dosporia endophytic behavior, an RNA-Seq analysis was carried outusing fungus-colonized barley roots. Using this technique we iden-tified a set of 7586 genes expressed from the P. chlamydosporiagenome (Supplementary Table 1). Fifty-seven percent of all P. chl-amydosporia genes coding for predicted secreted proteins (1,432)were detected to be expressed during endophytism. Within theBiological Process GO domain the genes expressed by this funguswere associated with a total of 28 GO terms, including primarymetabolic process (21% of the genes), cellular metabolic process(19%) and nitrogen compound metabolic process (Fig. 3C). Like-wise, regulation of biological processes (6%), biosynthetic pro-cesses (9%) and macromolecule metabolic process (6%) wererepresented GO terms. Within the Molecular Function GO domainwe found that the most represented terms were related to smallmolecule binding and hydrolase activity. Likewise, transferaseactivity, binding to nucleic acids, and protein binding were eachrepresented by a 16% fraction of expressed genes (Fig. 3C).

The genes found to be expressed in our transcriptomic analysisof barley root colonization by P. chlamydosporia were comparedwith those exhibiting a homolog within the PHI database (puta-tively associated with pathogenesis) and with those annotatedunder the interaction between organisms GO term, and a commonset of 32 genes was obtained (Supplementary Fig. 2A). The set ofgenes putatively associated with pathogenesis plus endophytismis shown in Supplementary Fig. 2B and Supplementary Table 2,the majority of which encoded hydrolytic enzymes and signaltransduction proteins. Hydrolases found to have homologs in thePHI database mostly included metalloproteases and a chitinaseprecursor, whereas those expressed under endophytism weremore diverse, including serine and rhomboid protease families anda protein phosphatase (Supplementary Fig. 2D and SupplementaryTable 2).

3.6. Hydrolytic enzymes encoded by the P. chlamydosporia genome

The nematode egg-shell constitutes the main barrier againstparasitism by nematophagous fungi. P. chlamydosporia employsan array of hydrolytic enzymes, including proteases, chitinases,esterases and lipases, in order to degrade and penetrate nematodeegg-shells (Huang et al., 2004; Yang et al., 2007). As illustrated inFig. 4, its genome contained an ample set of genes putatively encod-ing hydrolytic enzymes, over half of which were detected to beexpressed during root endophytic colonization (SupplementaryTable 3).

Biologicol Process Molecular Function

(A)

(B)

(C)

PHI homologuos

RNA-seq

Genome

Fig. 3. Gene Ontology (GO) functional annotation of proteins encoded by genes in the P. chlamydosporia genome. GO charts were generated using generic Slim terms at level 3within the GO Biological Process (left) and Molecular Function (right) domains. (A) Protein-coding genes predicted in the P. chlamydosporia genome, (B) P. chlamydosporiagenes with homologous counterparts in the PHI database, and (C) genes expressed during endophytic colonization of barley roots by P. chlamydosporia detected by RNA-Seq.

74 E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80

3.6.1. ProteasesWe carried out a batch Blast search against the complete MEROPS

protease database (Rawlings and Morton, 2008) and found 522genes coding for proteases, which were classified into six categoriesaccording to their catalytic type, and distributed in a total of 68 fam-ilies (Supplementary Table 3). Serine proteases (189 genes) were thelargest category of proteases encoded in the P. chlamydosporia gen-ome (Fig. 4), with 59% of genes in this family being expressed duringendophytism (Fig. 4). Serine proteases constituted the second larg-est family of hydrolytic enzymes expressed under endophytism(Fig. 5A). Among these enzymes, subtilisins and serine carboxypep-tidases are known to be involved in nematode egg-parasitism(Lopez-Llorca et al., 2002b; Ward et al., 2012) and expressed duringroot endophytic colonization (Lopez-Llorca et al., 2010) by this fun-gus. We found in this context that the P. chlamydosporia genomecoded for 32 serine proteases of the S8 family (subtilisins) and 16proteases of the S10 family (serine carboxypeptidases), 7 of the lat-ter being putatively secreted enzymes (Fig. 5B). Fifty percent ofgenes in the S10 family were expressed during root endophytism(Fig. 5B and Supplementary Table 3). A Blast search against the PHIdatabase returned a number of homologous genes coding forputatively secreted serine proteases belonging to other fungi(Supplementary Table 4). Among these genes, the P. chlamydosporiagenome encodes two S54 (rhomboid family) membrane proteases(Fig. 5B), identified in this study as putatively involved in endophyticcapacity (Supplementary Tables 2 and 3). Also during endophytism,we detected the expression of 55% of the S33 family members, thisbeing the family of serine proteases (prolyl aminopeptidases) with

the highest number of members identified in the genome(Supplementary Table 3). The second largest group of proteases inthis genome was metalloproteases, with 147 genes belonging to25 families (Supplementary Table 3), of which 71% were identifiedin our transcriptomic analysis (Fig. 4). The largest family withinmetalloproteases was glutamate carboxypeptidases, M20 (Fig. 5B).The P. chlamydosporia genome contained genes encoding 3 enzymesof the metalloproteases M36 (fungalysins) family, 9 of the M28(aminopeptidase Y-related), 6 of the M35 (deuterolysins) and 14of the M43 (cytophagalysins) (Fig. 5B), with representatives of allof them being expressed during endophytism (Fig. 5B andSupplementary Table 3). Other abundant families of putativelysecreted proteases were aspartic (A1) and cysteine proteases (Figs. 4and 5B), of which we detected expression of many of its membersduring root endophytism (Fig. 5A and Supplementary Table 3).

3.6.2. Glycoside hydrolasesBesides proteins, P. chlamydosporia needs to degrade structural

polysaccharides of nematode egg-shells, such as chitin. Using CAZydatabase models (see Section 2.3) we identified 305 genes encod-ing glycoside hydrolases (GH) and 159 encoding carbohydrateesterases (CE) in its genome, 200 and 54 of which, respectively,were putatively secreted (Fig. 4A and Supplementary Table 3). Dur-ing endophytic root colonization 60% and 39% of the genes identifiedas GH and CE, respectively, were expressed (Fig. 5B and Supplemen-tary Table 3). Among hydrolases the GH group included the largestnumber of genes expressed during endophytism (Fig. 5A). Chitinases(GH18) were the most abundant P. chlamydosporia glycoside

Fig. 4. Families of proteins encoded in the P. chlamydosporia genome. Protein families with an involvement in the different P. chlamydosporia lifestyles are shown grouped bydifferent colors according to their biological roles. Each bar represents the number of members of each protein family predicted in the genome, and the stripped area indicatesthe number of them predicted to be extracellular. The black line indicates the number of genes within each family that are expressed during endophytic root colonization.(For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80 75

hydrolases, represented by 22 genes, of which 15 were putativelysecreted (Fig. 5B and Supplementary Table 3). These enzymesdegrade the chitin present in the chitin–protein complex of thenematode egg-shell (Bird and McClure, 1976). Regarding chitosan-ases (GH75), the genome of this fungus encoded 11 enzymes of thisfamily, 10 of which were putatively secreted (Fig. 5A). Of theenzymes related with chitin/chitosan degradation, i.e. GH18 plusGH75 families, less than 40% of their members were expressedduring root endophytism (Fig. 5B). GH76 (a-1,6-mannanases)constituted the family exhibiting the highest number of putativelysecreted hydrolases, with 14 encoding genes (Fig. 5B). Genesencoding members of cellulase families (GH5–GH12) were also ex-pressed during root colonization (Fig. 5B) and exhibited homologywith enzymes in the PHI database (Supplementary Table 4). Wewere also able to identify expressed GH families involved in thedegradation of callose, lignocellulose and xylans (Fig. 5B), or inchanges in cell wall composition and morphogenesis (GH17,GH31, GH72 and GH125) in fungal pathogens (Fig. 5B andSupplementary Tables 2 and 3).

3.6.3. Carbohydrate esterasesThe largest family CE genes contained in the genome of

P. chlamydosporia was sterol esterases (CE10), represented by 93genes, 29 of which were predicted to encode putatively secretedenzymes and 36% of which were expressed during root endo-phytic colonization (Fig. 5B and Supplementary Table 3). Itsgenome encoded 9 cutinases (CE5 family) with homologous coun-terparts in the PHI database (Fig. 5B and Supplementary Table 4).We also detected 27 genes encoding triglyceride lipases and 11phospholipases (Fig. 5B) with homologs in the PHI database(Supplementary Table 4). Only 18% phospholipase genes wereexpressed during endophytic behavior, in contrast to the highnumber of triglyceride lipase genes (82%) expressed during thisphase (Fig. 5A).

3.7. Secondary metabolism gene clusters

P. chlamydosporia produces a variety of secondary metabolites,such as radicicol (=monorden), tetrahydromonorden, pseurotin A,pochonins A to J (Hellwig et al., 2003; Shinonaga et al., 2009 andZhou et al., 2010) and various aurovertin-type metabolites (Niuet al., 2010). In this context, we found that its genome containedgenes putatively encoding 15 polyketide synthases (PKS) and 12putative non-ribosomal peptide synthases (NRPS), together witha number of PKS and NRPS-like proteins and 4 NRPS-PKS hybridgenes (Supplementary Table 5). We also found a radicicol genecluster, Rdc1–Rdc5 (Zhou et al., 2010) (Supplementary Table 6).During endophytic root colonization, P. chlamydosporia expressed56% of the secondary metabolism pathway core genes identifiedin its genome (Supplementary Table 5). Among them we detectedthe expression of seven genes related to the radicicol cluster(Supplementary Table 6).

3.8. Genes involved in transport, detoxification and cell wallmodification

The P. chlamydosporia genome encoded 290 transporters of themajor facilitator superfamily (MFS), 58 ATP-binding cassette (ABC)transporters and 113 general transporters (Fig. 4 and SupplementaryTable 7), most of which exhibited homologs in the PHI database (Sup-plementary Table 5). During endophytic root colonization P. chlamy-dosporia expressed genes encoding drug resistance, sugar/inositol,oligopeptide and amino acid transporters (Fig. 4 and SupplementaryTable 8). Also, we detected several genes encoding oxidoreductases,many of them related to detoxification (Fig. 4 and SupplementaryTable 8). These comprised 110 cytochrome P450 (CYP) enzymes, anumber similar to those found in the entomopathogen M. anisopliaeand in fungal plant pathogens (Supplementary Table 7). Interest-ingly, the number of members of these oxidoreductase families,

Fig. 5. Hydrolytic enzymes encoded by the P. chlamydosporia genome and expressed during endophytic behavior. (A) Sector graph showing the percentage of hydrolyticenzyme-coding genes identified within each catalytic type that are expressed during root endophytic colonization and (B) selected hydrolytic enzymes are grouped bydifferent colors according to their substrate types. Each bar represents the number of hydrolytic enzymes belonging to each family represented in the genome, and thestripped area the number of them predicted to be secreted. The red line indicates the number of genes within each hydrolase family expressed during endophyticcolonization. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

76 E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80

which are likely involved in counteracting oxidative stress, washigher in P. chlamydosporia than in most invertebrate and plantpathogens (Supplementary Table 7). Sixty percent of CYP-codinggenes in the P. chlamydosporia genome were expressed during end-ophytism (Fig. 4) and 72% showed homology with genes in the PHIdatabase (Supplementary Table 8). Finally, the P. chlamydosporiagenome included genes coding for enzymes involved in cell wall bio-synthesis and modification, such as chitin synthesis activators (Sel-1domain-containing proteins), chitin synthases, lipopolysaccharide-modifying proteins and hydrophobins (Fig. 4), which were

expressed during endophytic colonization (Fig. 4 and SupplementaryTable 8).

3.9. Signal transduction and regulation of gene expression

In order to adjust to its different lifestyles (saprophytic, para-sitic and endophytic), P. chlamydosporia needs genes involved insignaling and regulation of gene expression. G proteins areinvolved in different biological processes in filamentous fungi,including development and pathogenesis, and are responsible as

E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80 77

well of transducing environmental signals. The genome of this fun-gus encoded eight G-protein subunits (Fig. 4), three of whichshowed homology with G proteins involved in vegetative growth,conidiation, conidium attachment, appressorium formation, mat-ing, and pathogenicity in Magnaporthe oryzae (Liu and Dean,1997). Six of these G protein-coding genes were expressed duringP. chlamydosporia endophytism (Fig. 4 and Supplementary Table 8).The genome of this fungus encoded 54 proteins homologous toPth11-like G protein-coupled receptors (GPCR) of Magnaporthespp., i.e. the same number found in the M. anisopliae genome (Sup-plementary Table 7). The P. chlamydosporia genome encoded aswell 27 small GTPase regulators, (96% of which had homology withgenes in the PHI database) and 12 Rab GTPase activators, all ofwhich presumably modulate its endophytic behavior (Fig. 4 andSupplementary Tables 2 and 8). Among proteins involved in theregulation of cell and metabolic processes, the P. chlamydosporiagenome encoded 153 protein kinases (PKs), 75% of which returnedhomologous partners within the PHI database (Fig. 4 and Supple-mentary Table 8). This number was similar to that found in ento-mopathogens and plant pathogens, except for M. oryzae(Supplementary Table 7). Together with PKs, we found genes cod-ing for histidine kinases (HKs) in the genome of P. chlamydosporia(Fig. 4), nearly all which had homologous partners in the PHI data-base and 14 of which were expressed in endophytism (Fig. 4 andSupplementary Table 8). Finally, its genome encoded 409 putativetranscription factors (TFs) grouped into six families (Fig. 4), ofwhich that containing the highest number of genes expressed un-der endophytism was the Zn2Cys6 fungal type TF family (Fig. 4 andSupplementary Table 8).

4. Discussion

In this study we used MPS techniques in combination with bio-informatic tools (Jackman and Birol, 2010; Yandell and Ence, 2012)to obtain the first genome sequence of a nematode-egg parasiticfungus. In addition, we used RNA-Seq to validate our bioinformat-ically-predicted gene models, this being the first transcriptomicstudy of root endophytic colonization by a nematophagous fungus.P. chlamydosporia uses appressoria for host penetration (Escuderoand Lopez-Llorca, 2012; Lopez-Llorca et al., 2002b), just likeentomopathogenic (St. Leger et al., 1991) and plant-pathogenicfungi (Tucker and Talbot, 2001). On the contrary, nematode-trapping fungi, such as Arthrobotrys oligospora, generate complexhyphal networks and constrictive rings to capture motile nema-todes (Liu et al., 2012; Yang et al., 2011). These differences in path-ogenesis mechanisms are reflected in the higher homology wehave found between P. chlamydosporia predicted protein-codinggenes and those of entomopathogenic fungi (Metarhizium spp.)compared to those of the nematode-trapping fungus A. oligospora.This would support the idea that the genomic machineries of nem-atode egg-parasites and trapping fungi are very different, and thatthe nematophagous habit evolved independently several times inthe Fungi. Our phylogenomic tree shows the existence of a closerelationship between P. chlamydosporia, entomopathogenic, myco-parasitic (Trichoderma spp.) and – especially – endophytic fungi(E. festucae). However, other specialized plant pathogens (Verticilliumspp. wilt fungi) are less related to P. chlamydosporia. This confirmsthat the former Verticillium genus, which included nematode-egg(such as P. chlamydosporia) and insect parasites, plant pathogensand soil saprophytes, was artificially based on morphological fea-tures (mainly conidiophore morphology). Taken together, these re-sults support the taxonomic affiliation of P. chlamydosporia as wellas its ecology as endophyte and invertebrate pathogen (nematode-egg parasite). Also, they provide evidence of strong links withentomopathogenic fungi and of an existing evolutionary distance

with nematode-trapping fungi. The present genome-wide studyis also consistent with our recent sequence comparative analysisof VCP1 and P32 serine proteases from the closely related egg-par-asites P. chlamydosporia and Pochonia rubescens, respectively,which exhibited higher similarity to proteases of fungal pathogensof insects than to those of nematode-trapping fungi (Larriba et al.,2012). The multitrophic lifestyle of P. chlamydosporia, i.e. as soilsaprophyte, nematode-egg pathogen and root endophyte, is re-flected in the large number of putatively secreted enzymesencoded by its genome, being the species showing the highestnumber of these among all ascomycete genomes sequenced to date(Galagan et al., 2005; Gao et al., 2011; Islam et al., 2012; Xiao et al.,2012). More than half of them are expressed during P. chlamydos-poria endophytic behavior. In this context, fungal adaptation toseveral lifestyles is thought to require a large number of hydrolyticenzymes and transporters for an efficient use of the diverse nutri-ents available (Gao et al., 2011). Accordingly, 30% of the P. chlamy-dosporia genes annotated within the Molecular Function GOdomain are involved in the hydrolysis of a wide array of substrates,which is one of the most represented gene sets expressed duringroot endophytism. For instance, P. chlamydosporia genome encodesmore proteases (and putatively secreted proteases) than the fungalinsect pathogens M. anisopliae and M. acridum (Gao et al., 2011).The most studied proteases in P. chlamydosporia are those belong-ing to the serine protease category, among which subtilisins (S8)are the family with the highest number of putatively secretedmembers in its genome. Within this family, the VCP1 protease(Morton et al., 2003) has been found to be involved in degradationand penetration of the nematode egg-shell (Lopez-Llorca et al.,2002b) and to participate in the endophytic phase of the fungus(Lopez-Llorca et al., 2010). It must be mentioned that serine prote-ases are well known pathogenic determinants of both entomopath-ogenic (St. Leger, 1995) and human pathogenic fungi (Monod,2008). Prolyl aminopeptidases (S33) are the most abundant serineprotease family in the P. chlamydosporia genome. To this respect,proline residues constitute a large fraction (35%) of the amino acidsof proteins forming the Tylenchida family egg-shell (to whichplant-parasitic nematodes such as M. javanica belong) (Bird andMcClure, 1976). Likewise, the finding of P. chlamydosporia homolo-gous protease genes in the PHI database related to the evasion ofhost defenses, suggests that its proteases may play roles other thannematode egg-shell disruption (Hung et al., 2005; Jia et al., 2000;Newport et al., 2003; Soloviev et al., 2011). To this respect, thenematode Meloidogyne incognita genome contains genes relatedto the immune response and antifungal defenses (Abad et al.,2008). Expression of the VCP1 protease and the serine carboxypep-tidase SCP1 has been detected during P. chlamydosporia endophy-tism (Lopez-Llorca et al., 2010). Additionally, we have identifiedin this work several families of expressed proteases putatively re-lated to fungal–plant interaction, such as the rhomboid proteasefamily (S54), likely involved in its endophytic behavior. Alongside,metalloproteases M28, M35, M36 and M43 expressed during P. chl-amydosporia endophytism have been related to root endophytismby the basidiomycete Piriformospora indica, presumably by allow-ing degradation of plant cell wall proteins (Zuccaro et al., 2011).

Chitin is a major component of nematode egg-shells (Bird andMcClure, 1976; Wharton, 1980), and P. chlamydosporia is known toexpress chitinases for egg penetration (Gortari and Hours, 2008;Mi et al., 2010; Tikhonov et al., 2002). Our P. chlamydosporia genomeanalysis has shown that chitinases (GH18) are the most representedfamily of GH, the majority of them predicted to be putatively se-creted. Chitinases and chitosanases are coexpressed with proteaseVCP1 by P. chlamydosporia in the presence of chitin (Palma-Guerreroet al., 2008), perhaps suggesting their co-involvement in the patho-genesis of nematode eggs. The number of GH enzymes encoded by afungus genome has been linked to its capacity to adaptation to

Fig. 6. Tritrophic lifestyles of the nematophagous fungus P. chlamydosporia. The three trophic modes of P. chlamydosporia as nematode-egg parasite (P), soil saprophyte (S)and root endophyte (E), are shown in the figure. The parasitic life-mode of P. chlamydosporia is illustrated (P inset) by an image of a GFP transformant strain of this fungusinfecting a plant-parasitic nematode (Meloidogyne javanica) egg. The fungus forms an appresorium on the egg-shell from which penetration and colonization of egg contentstakes place (from Escudero and Lopez-Llorca (2012)). P. chlamydosporia is a true endophyte, since it colonizes living barley root cells (E inset). The image portraits the funguspenetrating the cell wall of two adjacent cortex cells (arrowheads). The sample has been labeled with the membrane tracker FM4-64 to show that the fungus-colonized cellsretain membrane integrity (blue staining) (from Macia-Vicente et al. (2009a)) Finally, the saprophytic lifestyle of P. chlamydosporia in the soil is illustrated (S inset) by achlamydospore (resting stage) of the fungus (picture gift from Dr. Palma-Guerrero, University of California, Berkeley, USA). P. chlamydosporia switches lifestyles and makes adifferential use of protein families encoded in its genome. The suggested importance of key protein families in the different lifestyles of this fungus is indicated by the fontsize of its corresponding protein family abbreviation. Hydrolytic enzymes are in brackets. Abbreviations: PROT: proteases, GH: glycoside hydrolases, CE: carbohydrateesterases, DEX: detoxification, SM: secondary metabolism, TRS, transporters, TF: transcription factors, ST: signal transducers. (For interpretation of the references to color inthis figure legend, the reader is referred to the web version of this article.)

78 E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80

diverse environments (Van den Brink and De Vries, 2011).P. chlamydosporia expresses 60% of its GH encoding genes duringendophytism. These include GH enzymes that have been related tothe degradation of cellulose, hemicellulose, xylans and otherconstituents of the plant cell wall (Gibson, 2012). Additionally, thisfungus exhibits a large number of CE enzymes, which would cleaveester bonds present in plant polysaccharides (Biely, 2012). Trans-porters that have been involved in the trophic behavior of fungalendophytes (Zuccaro et al., 2011) and during pathogenesis of nem-atode eggs (Rosso et al., 2011) are encoded in the P. chlamydosporiagenome and exhibit homologs in the PHI database, some of whichare also expressed during endophytism. P. chlamydosporia also ex-presses a large number of genes related to sugar/inositol transport,which are involved in the establishment of plant–fungus relation-ships by M. anisopliae (Fang and St. Leger, 2010).

The multiple modes of life of P. chlamydosporia would require anextensive signaling machinery to perceive and respond to a widevariety of environmental stimuli. In this light, its genome containsmore genes encoding G-protein a-subunits than the entomophato-gen M. anisopliae, which are involved in the P. chlamydosporia endo-phytic phase, as well as a larger number of Pth11-like G-proteinsinvolved in physiological processes in the plant pathogen Magna-porthe grisea (DeZwaan et al., 1999). Several genes encoding proteinkinases were also identified here in the P. chlamydosporia genome, atype of proteins that have been involved in the regulation of viru-lence genes in the entomopathogenic fungus M. anisopliae (Fanget al., 2009). Our analyses show that most families of genes codingfor proteins related to signal sensing and transduction in P. chlam-ydosporia exhibit homologous genes in the PHI database and areexpressed in endophytism. During the pathogenesis of nematodeeggs, P. chlamydosporia is known to express transcription factors(Rosso et al., 2011) belonging to Zn2Cys6 fungal-type, bZIP andbromodomain-containing TF families, which are well representedin the P. chlamydosporia genome. These observations highlight theimportance of identifying the signaling and transduction pathways

involved in the transitions between diverse P. chlamydosporialifestyles.

Nematode-egg parasitism and root endophytism by P. chlamy-dosporia requires a broad set of genes involved in detoxificationand resistance to oxidative stress, such as cytochrome P450 genes,present in a similar number than in the M. anisopliae genome (Gaoet al., 2011). The P. chlamydosporia genome encodes more monox-ygenases that any insect-pathogenic fungal genome sequenced todate (Xiao et al., 2012), and which are presumably involved in itsendophytic phase. Monoxygenases have been found in fungal oxi-dation of plant phenolic compounds, thereby reducing plant de-fenses (Morrissey and Osbourn, 1999). Besides, P. chlamydosporiaencodes a large number of zinc type alcohol dehydrogenases,which are necessary for mannitol synthesis, a sugar associatedwith stress tolerance and energy storage in fungi (Solomon et al.,2007). Finally, the P. chlamydosporia genome includes genes forthe synthesis of a large number of secondary metabolites (Hellwiget al., 2003; Niu et al., 2010; Shinonaga et al., 2009). Our analysisallowed us to identify the elements of a gene cluster involved inthe biosynthesis of radicicol, a compound which is the structuralbasis for pochonin production (Reeves et al., 2008). Expression ofPKS genes (necessary for polyketide biosynthesis) has been de-tected during the P. chlamydosporia endophytic and saprophyticphases (Rosso et al., 2011). There is also evidence that the produc-tion of secondary metabolites is involved in the pathogenesis ofnematode eggs (Niu et al., 2010) and in adaptation to the root envi-ronment (Johnson et al., 2007).

5. Conclusions

In this work we show evidence that the genome of the nema-tode-egg parasite P. chlamydosporia is most closely related to thoseof Clavicipitaceous enthomopathogenic fungi (Metarhizium spp.).Both fungi form a clade with E. festucae, an endophyte. This

E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80 79

supports the presence of endophytism in both nematophagous andentomopathogenic fungi. In addition, the P. chlamydosporia gen-ome is evolutionarily close to that of mycoparasitic (Trichodermaspp.) and plant pathogenic (Fusarium spp.) fungi. However, thenematode-trapping fungus A. oligospora is phylogenomically farapart from P. chlamydosporia. This would agree with the idea ofindependent and multiple evolution of nematophagous behaviorin fungi. The wide array of hydrolytic enzymes and transportersencoded by the P. chlamydosporia genome support the observationsof multitrophic behavior (pathogenic, endophytic and saprophytic)by P. chlamydosporia (Fig. 6). To this respect, this fungus expressesca. 62% of its protein-coding genes during barley root endophy-tism. The number and diversity of genes related to signal transduc-tion and gene regulation in its genome suggests that the transitionsbetween the different trophic modes require a sophisticated sig-naling network (Fig. 6). This study provides the ‘‘essential parts’’list to understand the molecular basis of these phenomena andthe interactions among their complex underlying pathways.Furthermore, the genomic-level information here provided onP. chlamydosporia should be helpful to enhance the capabilities ofthis fungus as a biocontrol agent of plant-parasitic nematodesand a growth-promoting agent of crop plants (Lahrmann andZuccaro, 2012).

Acknowledgments

This research was funded by the Spanish Ministry of Scienceand Innovation Grant AGL2011-29297. We acknowledge the assis-tance of Dax Torti, Lawrence Heisler and Tanja Durbic of the Don-nelly Sequencing Center at the University of Toronto. We thankNatalia Navarro Román (Department of Ecology, University of Ali-cante) as well as Rafael López and Berenice Güerri (Glen Biotech)for their help with the artwork.

Appendix A. Supplementary data

Supplementary data associated with this article can be found, inthe online version, at http://dx.doi.org/10.1016/j.fgb.2014.02.002.

References

Abad, P., Gouzy, J., Aury, J.M., Castagnone-Sereno, P., Danchin, E.G., et al., 2008.Genome sequence of the metazoan plant-parasitic nematode Meloidogyneincognita. Nat. Biotechnol. 26, 909–915. http://dx.doi.org/10.1038/nbt.1482.

Barluenga, S., Fontaine, J.G., Wang, C., Aouadi, K., Chen, R., Beebe, K., Neckers, L.,Winssinger, N., 2009. Inhibition of HSP90 with pochoximes: SAR and structure-based insights. Chem. Biochem. 10, 2753–2759. http://dx.doi.org/10.1002/cbic.200900494.

Biely, P., 2012. Microbial carbohydrate esterases deacetylating plantpolysaccharides. Biotechnol. Adv. 30, 1575–1588. http://dx.doi.org/10.1016/j.biotechadv.2012.04.010.

Bird, A.F., McClure, M.A., 1976. The tylenchid (Nematoda) egg shell: structure,composition and permeability. Parasitology 72, 19–28. http://dx.doi.org/10.1017/S0031182000043158.

Bordallo, J.J., Lopez-Llorca, L.V., Jansson, H.-B., Salinas, J., Persmark, L., Asensio, L.,2002. Colonization of plant roots by egg-parasitic and nematode-trapping fungi.New Phytol. 154, 491–499. http://dx.doi.org/10.1046/j.1469-8137.2002.00399.x.

Casas-Flores, S., Herrera-Estrella, A., 2007. Antagonism of plant parasitic nematodesby fungi. In: Kubicek, C.P., Druzhinina, I.S. (Eds.), The Mycota. Springer, Berlin,pp. 147–157, http://dx.doi.org/10.1007/978-3-540-71840-6_9.

Cox, M.P., Peterson, D.A., Biggs, P.J., 2010. SolexaQA: at-a-glance quality assessmentof Illumina second-generation sequencing data. BMC Bioinform. 11, 485. http://dx.doi.org/10.1186/1471-2105-11-485.

DeZwaan, T.M., Carroll, A.M., Valent, B., Sweigard, J.A., 1999. Magnaporthe griseapth11p is a novel plasma membrane protein that mediates appressoriumdifferentiation in response to inductive substrate cues. Plant Cell 11, 2013–2030. http://dx.doi.org/10.1105/tpc.11.10.2013.

Dias-Arieira, C.R., Santana, S.M., de Freitas, L.G., da Cunha, T.P.L., Biela, F., Puerari,H.H., Chiamolera, F.M., 2011. Efficiency of Pochonia chlamydosporia inMeloidogyne incognita control in lettuce crop (Lactuca sativa L.). J. Food Agric.Environ. 9, 561–563.

Domsch, K.H., Gams, W., Anderson, T-H., 1993. Compendium of Soil Fungi. vol. I.IHW-Verlag, Regensburg, Germany, pp. 834–836.

Ebadi, M., Fatemy, S., Riahi, H., 2009. Evaluation of Pochonia chlamydosporia var.chlamydosporia as a control agent of Meloidogyne javanica on pistachio.Biocontrol Sci. Technol. 19, 689–700. http://dx.doi.org/10.1080/09583150903051844.

Escudero, N., Lopez-Llorca, L.V., 2012. Effects on plant growth and root-knotnematode infection of an endophytic GFP transformant of the nematophagousfungus Pochonia chlamydosporia. Symbiosis 57, 33–42. http://dx.doi.org/10.1007/s13199-012-0173-3.

Fang, W., St. Leger, R.J., 2010. Mrt, a gene unique to fungi, encodes anoligosaccharide transporter and facilitates rhizosphere competency inMetarhizium robertsii. Plant Physiol. 154, 1549–1557. http://dx.doi.org/10.1104/pp.110.163014.

Fang, W., Pava-Ripoll, M., Wang, S., St. Leger, R., 2009. Protein kinase A regulatesproduction of virulence determinants by the entomopathogenic fungus,Metarhizium robertsii. Fungal Genet. Biol. 46, 277–285. http://dx.doi.org/10.1016/j.fgb.2008.

Galagan, J.E., Calvo, S.E., Cuomo, C., Ma, L.J., Wortman, J.R., Batzoglou, S., Lee, S.I.,Basturkmen, M., Spevak, C.C., Clutterbuck, J., et al., 2005. Sequencing ofAspergillus nidulans and comparative analysis with A. fumigatus and A.oryzae. Nature 438 (7071), 1105–1115.

Gao, Q., Jin, K., Ying, S.H., Zhang, Y., Xiao, G., Shang, Y., Duan, Z., Hu, X., Xie, X.Q.,Zhou, G., et al., 2011. Genome sequencing and comparative transcriptomics ofthe model entomopathogenic fungi Metarhizium anisopliae and M. acridum. PLoSGenet. 7 (1), e1001264.

Gibson, L.J., 2012. The hierarchical structure and mechanics of plant materials. J. R.Soc. Interface 9, 2749–2766, doi:10.1098/rsif.2012.0341.

Gortari, M.C., Hours, R.A., 2008. Fungal chitinases and their biological role in theantagonism onto nematode eggs. A review. Mycol. Prog. 7, 221–238. http://dx.doi.org/10.1007/s11557-008-0571-3.

Hellwig, V., Mayer-Bartschmid, A., Müller, H., Greif, G., Kleymann, G., Zitzmann, W.,Tichy, H.-V., Stadler, M., 2003. Pochonins A–F, new antiviral and antiparasiticresorcylic acid lactones from Pochonia chlamydosporia var. catenulata. J. Nat.Prod. 66, 829–837. http://dx.doi.org/10.1021/np020556v.

Holt, C., Yandell, M., 2011. MAKER2: an annotation pipeline and genome-databasemanagement tool for second-generation genome projects. BMC Bioinform. 22(12), 491.

Huang, X., Zhao, N., Zhang, K., 2004. Extracellular enzymes serving as virulencefactors in nematophagous fungi involved in infection of the host. Res. Microbiol.115, 811–816, http://dx.doi.org/10.1016/j.resmic.2004.07.003.

Hung, C.Y., Seshan, K.R., Yu, J.J., Schaller, R., Xue, J., Basrur, V., Gardner, M.J., Cole,G.T., 2005. A metalloproteinase of Coccidioides posadasii contributes to evasionof host detection. Infect. Immun. 73, 6689–6703, http://dx.doi.org/10.1128/IAI.73.10.6689-6703.2005.

Islam, M.S., Haque, M.S., Islam, M.M., Emdad, E.M., Halim, A., Hossen, Q.M., Hossain,M.Z., Ahmed, B., et al., 2012. Tools to kill: genome of one of the most destructiveplant pathogenic fungi Macrophomina phaseolina. BMC Genomics 13, e493.http://dx.doi.org/10.1186/1471-2164-13-493.

Jackman, S.D., Birol, I., 2010. Assembling genomes using short-read sequencingtechnology. Genome Biol. 11, e202. http://dx.doi.org/10.1186/gb-2010-11-1-202.

Jia, Y., McAdams, S.A., Bryan, G.T., Hershey, H.P., Valent, B., 2000. Direct interactionof resistance gene and avirulence gene products confers rice blast resistance.EMBO J. 19, 4004–4014. http://dx.doi.org/10.1093/emboj/19.15.4004.

Johnson, R., Voisey, C., Johnson, L., Pratt, J., Fleetwood, D., Khan, A., Bryan, G., 2007.Distribution of NRPS gene families within the neotyphodium/epichloë complex.Fungal Genet. Biol. 44, 1180–1190. http://dx.doi.org/10.1016/j.fgb.2007.04.009.

Kerry, B.R., 2000. Rhizosphere interactions and the exploitation of microbial agentsfor the biological control of plant-parasitic nematodes. Annu. Rev. Phytopathol.38, 423–441. http://dx.doi.org/10.1146/annurev.phyto.38.1.423.

Kück, P., Meusemann, K., 2010. FASconCAT: convenient handling of data matrices.Mol. Phylogenet. Evol. 56, 1115–1118. http://dx.doi.org/10.1016/j.ympev.2010.04.024.

Lahrmann, U., Zuccaro, A., 2012. Opprimo ergo sum-evasion and suppression in theroot endophytic fungus Piriformospora indica. Mol. Plant Microbe Interact. 25,727–737. http://dx.doi.org/10.1094/MPMI-11-11-0291.

Langmead, B., Trapnell, C., Pop, M., Salzberg, S.L., 2009. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. GenomeBiol. 10, R25. http://dx.doi.org/10.1186/gb-2009-10-3-r25.

Larriba, E., Martín-Nieto, J., Lopez-Llorca, L.V., 2012. Gene cloning, molecularmodeling, and phylogenetics of serine protease P32 and serinecarboxypeptidase SCP1 from nematophagous fungi Pochonia rubescens andPochonia chlamydosporia. Can. J. Microbiol. 58, 815–827. http://dx.doi.org/10.1139/W2012-054.

Lechner, M., Findeiss, S., Steiner, L., Marz, M., Stadler, P.F., Prohaska, S.J., 2011.Proteinortho: detection of (co-)orthologs in large-scale analysis. BMCBioinform. 12, 124. http://dx.doi.org/10.1186/1471-2105-12-124.

Liu, S., Dean, R.A., 1997. G protein subunit genes control growth, development, andpathogenicity of Magnaporthe grisea. Mol. Plant Microbe Interact. 10, 1075–1086.

Liu, K., Tian, J., Xiang, M., Liu, X., 2012. How carnivorous fungi use three-celledconstricting rings to trap nematodes. Prot. Cell. 3, 325–328. http://dx.doi.org/10.1007/s13238-012-2031-8.

Lopez-Llorca, L.V., Robertson, W.M., 1992. Immunocytochemical localization of a32-kDa protease from the nematophagous fungus Verticillium suchlasporium in

80 E. Larriba et al. / Fungal Genetics and Biology 65 (2014) 69–80

infected nematode eggs. Exp. Mycol. 16, 261–267. http://dx.doi.org/10.1016/0147-5975(92)90002-9.

Lopez-Llorca, L.V., Bordallo, J.J., Salinas, J., Monfort, E., López-Serna, M.L., 2002a. Useof light and scanning electron microscopy to examine colonisation of barleyrhizosphere by the nematophagous fungus Verticillium chlamydosporium.Micron 33, 261–267. http://dx.doi.org/10.1016/S0968-4328(00)00070-6.

Lopez-Llorca, L.V., Olivares-Bernabeu, C., Salinas, J., Jansson, H.-B., Kolattukudy, P.E.,2002b. Pre-penetration events in fungal parasitism of nematode eggs. Mycol.Res. 106, 499–506. http://dx.doi.org/10.1017/S0953756202005798.

Lopez-Llorca, L.V., Gómez-Vidal, S., Monfort, E., Larriba, E., Casado-Vela, J., Elortza, F.,Jansson, H.-B., Salinas, J., Martín-Nieto, J., 2010. Expression of serine proteasesin egg-parasitic nematophagous fungi during barley root colonization. FungalGenet. Biol. 47, 342–351. http://dx.doi.org/10.1016/j.fgb.2010.01.004.

Lowe, T.M., Eddy, S.R., 1997. TRNAscan-SE: a program for improved detection oftransfer RNA genes in genomic sequence. Nucl. Acids Res. 25, 955–964. http://dx.doi.org/10.1093/nar/25.5.955.

Macia-Vicente, J.G., Jansson, H.-B., Talbot, N.J., Lopez-Llorca, L.V., 2009a. Real-timePCR quantification and live-cell imaging of endophytic colonization of barley(Hordeum vulgare) roots by Fusarium equiseti and Pochonia chlamydosporia.New Phytol. 182, 213–228. http://dx.doi.org/10.1111/j.1469-8137.2008.02743.x.

Macia-Vicente, J.G., Rosso, L.C., Ciancio, A., Jansson, H.-B., Lopez-Llorca, L.V., 2009b.Colonisation of barley roots by endophytic Fusarium equiseti and Pochoniachlamydosporia: effects on plant growth and disease. Ann. Appl. Biol. 155, 391–401. http://dx.doi.org/10.1111/j.1744-7348.2009.00352.x.

Martin, M., 2011. Cutadapt removes adapter sequences from high-throughputsequencing reads. EMBnet.journal. <http://journal.embnet.org/index.php/embnetjournal/article/view/200>.

Mi, Q., Yang, J., Ye, F., Gan, Z., Wu, C., Niu, X., Zou, C., Zhang, K.-Q., 2010. Cloning andoverexpression of Pochonia chlamydosporia chitinase gene pcchi44, a potentialvirulence factor in infection against nematodes. Process Biochem. 45, 810–814.http://dx.doi.org/10.1016/j.procbio.2010.01.022.

Monfort, E., Lopez-Llorca, L.V., Jansson, H.-B., Salinas, J., Park, J.O., Sivasithamparam,K., 2005. Colonisation of seminal roots of wheat and barley by egg-parasiticnematophagous fungi and their effects on Gaeumannomyces graminis var. triticiand development of root-rot. Soil Biol. Biochem. 37, 1229–1235. http://dx.doi.org/10.1016/j.soilbio.2004.11.019.

Monod, M., 2008. Secreted proteases from dermatophytes. Mycopathologia 166,285–294. http://dx.doi.org/10.1007/s11046-008-9105-4.

Morrissey, J.P., Osbourn, A.E., 1999. Fungal resistance to plant antibiotics as amechanism of pathogenesis. Microbiol. Mol. Biol. Rev. 63, 708–724.

Morton, C.O., Hirsch, P.R., Peberdy, J.F., Kerry, B.R., 2003. Cloning of and geneticvariation in protease VCP1 from the nematophagous fungus Pochoniachlamydosporia. Mycol. Res. 107, 38–46. http://dx.doi.org/10.1017/S0953756202007050.

Newport, G., Kuo, A., Flattery, A., Gill, C., Blake, J.J., Kurtz, M.B., Abruzzo, G.K.,Agabian, N., 2003. Inactivation of Kex2 diminishes the virulence of Candidaalbicans. J. Biol. Chem. 278, 1713–1720. http://dx.doi.org/10.1074/jbc.M209713200.

Niu, X.M., Wang, Y.L., Chu, Y.S., Xue, H.X., Li, N., Wei, L.X., Mo, M.H., Zhang, K.Q.,2010. Nematodetoxic aurovertin-type metabolites from a root-knot nematodeparasitic fungus Pochonia chlamydosporia. J. Agric. Food Chem. 58, 828–834.http://dx.doi.org/10.1021/jf903259n.

Notredame, C., Higgins, D.G., Heringa, J., 2000. T-Coffee: a novel method for fast andaccurate multiple sequence alignment. J. Mol. Biol. 302, 205–217, http://dx.doi.org/10.1006/jmbi.2000.4042.

Palma-Guerrero, J., Jansson, H.-B., Salinas, J., Lopez-Llorca, L.V., 2008. Effect ofchitosan on hyphal growth and spore germination of plant pathogenic andbiocontrol fungi. J. Appl. Microbiol. 104, 541–553. http://dx.doi.org/10.1111/j.1365-2672.2007.03567.x.

Rawlings, N.D., Morton, F.R., 2008. The MEROPS batch BLAST: a tool to detectpeptidases their and non-peptidase homologues in a genome. Biochimie 90,243–259. http://dx.doi.org/10.1016/j.biochi.2007.09.014.

Reeves, C.D., Hu, Z., Reid, R., Kealey, J.T., 2008. Genes for the biosynthesis of thefungal polyketides hypothemycin from Hypomyces subiculosus and radicicolfrom Pochonia chlamydosporia. Appl. Environ. Microbiol. 74, 5121–5129. http://dx.doi.org/10.1128/AEM.00478-08.

Rosso, L.C., Finetti-Sialer, M.M., Hirsch, P.R., Ciancio, A., Kerry, B.R., Clark, I.M., 2011.Transcriptome analysis shows differential gene expression in the saprotrophicto parasitic transition of Pochonia chlamydosporia. Appl. Microbiol. Biotechnol.90, 1981–1994. http://dx.doi.org/10.1007/s00253-011-3282-7.

Schmidt, H.A., Strimmer, K., Vingron, M., von Haeseler, A., 2002. TREE-PUZZLE:maximum likelihood phylogenetic analysis using quartets and parallelcomputing. Bioinformatics 18, 502–504.

Shinonaga, H., Kawamura, Y., Ikeda, A., Aoki, M., Sakai, N., Fujimoto, N., Kawashima,A., 2009. The search for a hair-growth stimulant: new radicicol analogues asWNT-5A expression inhibitors from Pochonia chlamydosporia var.chlamydosporia. Tetrahedron Lett. 50, 108–110. http://dx.doi.org/10.1016/j.tetlet.2008.10.099.

Solomon, P.S., Waters, O.D.C., Oliver, R.P., 2007. Decoding the mannitol enigma infilamentous fungi. Trends Microbiol. 15, 257–262. http://dx.doi.org/10.1016/j.tim.2007.04.002.

Soloviev, D.A., Jawhara, S., Fonzi, W.A., 2011. Regulation of innate immune responseto Candida albicans infections by aMb2-Pra1p interaction. Infect. Immun. 79,1546–1558. http://dx.doi.org/10.1128/IAI.00650-10.

St. Leger, R., 1995. The role of cuticle-degrading proteases in fungal pathogenesis ofinsects. Can. J. Bot. 73, 1119–1125. http://dx.doi.org/10.1139/b95-367.

St. Leger, R.J., Goettel, M., Roberts, D.W., Staples, R.C., 1991. Prepenetration eventsduring infection of host cuticle by Metarhizium anisopliae. J. Invertebr. Pathol.58, 168–179. http://dx.doi.org/10.1016/0022-2011(91)90061-T.

Stanke, M., Keller, O., Gunduz, I., Hayes, A., Waack, S., Morgenstern, B., 2006.AUGUSTUS: ab initio prediction of alternative transcripts. Nucl. Acids. Res. 34,W435–W439.

Stöver, B.C., Müller, K.F., 2010. TreeGraph 2: combining and visualizing evidencefrom different phylogenetic analyses. BMC Bioinform. 11, 7. http://dx.doi.org/10.1186/1471-2105-11-7.

Sung, G.-H., Hywel-Jones, N.L., Sung, J.-M., Luangsa-ard, J.J., Shrestha, B., Spatafora,J.W., 2007. Phylogenetic classification of Cordyceps and the clavicipitaceousfungi. Stud. Mycol. 57, 5–59. http://dx.doi.org/10.3114/sim.2007.57.01.

Ter-Hovhannisyan, V., Lomsadze, A., Chernoff, Y.O., Borodovsky, M., 2008. Geneprediction in novel fungal genomes using an ab initio algorithm withunsupervised training. Genome Res. 18, 1979–1990. http://dx.doi.org/10.1101/gr.081612.108.

Tikhonov, V.E., Lopez-Llorca, L.V., Salinas, J., Jansson, H.-B., 2002. Purification andcharacterization of chitinases from the nematophagous fungi Verticilliumchlamydosporium and V. suchlasporium. Fungal Genet. Biol. 35, 67–78, http://dx.doi.org/10.1006/fgbi.2001.1312.

Trapnell, C., Pachter, L., Salzberg, S.L., 2009. TopHat: discovering splice junctionswith RNA-Seq. Bioinformatics 25, 1105–1111. http://dx.doi.org/10.1093/bioinformatics/btp120.

Tucker, S.L., Talbot, N.J., 2001. Surface attachment and pre-penetration stagedevelopment by plant pathogenic fungi. Annu. Rev. Phytopathol. 39, 385–441.http://dx.doi.org/10.1146/annurev.phyto.39.1.385.

Van Den Brink, J., De Vries, R.P., 2011. Fungal enzyme sets for plant polysaccharidedegradation. Appl. Microbiol. Biotechnol. 91, 1477–1492. http://dx.doi.org/10.1007/s00253-011-3473-2.

Wang, C., Hu, G., St. Leger, R.J., 2005. Differential gene expression by Metarhiziumanisopliae growing in root exudate and host (Manduca sexta) cuticle orhemolymph reveals mechanisms of physiological adaptation. Fungal Genet.Biol. 42, 704–718.

Ward, E., Kerry, B.R., Manzanilla-López, R.H., Mutua, G., Devonshire, J., Kimenju, J.,Hirsch, P.R., 2012. The Pochonia chlamydosporia serine protease gene vcp1 issubject to regulation by carbon, nitrogen and pH: implications for nematodebiocontrol. PLoS ONE 7 (4), e35657. http://dx.doi.org/10.1371/journal.pone.0035657.

Wharton, D., 1980. Nematode egg-shells. Parasitology 81, 447–463.Winnenburg, R., Urban, M., Beacham, A., Baldwin, T.K., Holland, S., Lindeberg, M.,

Hansen, H., Rawlings, C., Hammond-Kosack, K.E., Kohler, J., 2008. PHI-baseupdate: additions to the pathogen host interaction database. Nucleic Acids Res.36, D572–D576. http://dx.doi.org/10.1093/nar/gkm858.

Xiao, G., Ying, S.H., Zheng, P., Wang, Z.L., Zhang, S., et al., 2012. Genomicperspectives on the evolution of fungal entomopathogenicity in Beauveriabassiana. Sci. Rep. 2, 483. http://dx.doi.org/10.1038/srep00483.

Yandell, M., Ence, D., 2012. A beginner’s guide to eukaryotic genome annotation.Nat. Rev. Genet. 13, 329–342. http://dx.doi.org/10.1038/nrg3174.

Yang, J.K., Tian, B.Y., Liang, L.M., Zhang, K.Q., 2007. Extracellular enzymes and thepathogenesis of nematophagous fungi. Appl. Microbiol. Biotechnol. 75, 21–31.http://dx.doi.org/10.1007/s00253-007-0881-4.

Yang, J., Wang, L., Ji, X., Feng, Y., Li, X., et al., 2011. Genomic and proteomic analysesof the fungus Arthrobotrys oligospora provide insights into nematode-trapformation. PLoS Pathog. 7 (9), e1002179. http://dx.doi.org/10.1371/journal.ppat.1002179.

Zare, R., Gams, W., Evans, H.C., 2001. A revision of Verticillium section Prostrata V.The genus Pochonia, with notes on Rotiferophthora. Nova Hedwigia 73, 51–86.

Zhang, C., Xia, Y., 2008. Identification of genes preferentially expressed duringmicrocycle conidiation of Metarhizium anisopliae using suppression subtractivehybridization. FEMS Microbiol. Lett. 286, 71–77. http://dx.doi.org/10.1111/j.1574-6968.2008.01257.x.

Zhang, C., Xia, Y., 2009. Identification of genes differentially expressed in vivo byMetarhizium anisopliae in the hemolymph of Locusta migratoria usingsuppression-subtractive hybridization. Curr. Genet. 55, 399–407. http://dx.doi.org/10.1007/s00294-009-0254-x.

Zheng, P., Xia, Y., Xiao, G., Xiong, C., Hu, X., et al., 2011. Genome sequence of theinsect pathogenic fungus Cordyceps militaris, a valued traditional Chinesemedicine. Genome Biol. 12, R116. http://dx.doi.org/10.1186/gb-2011-12-11-r116.

Zhou, H., Qiao, K., Gao, Z., Vederas, J.C., Tang, Y., 2010. Insights into radicicolbiosynthesis via heterologous synthesis of intermediates and analogs. J. Biol.Chem. 285, 41412–41421. http://dx.doi.org/10.1074/jbc.M110.183574.

Zuccaro, A., Lahrmann, U., Güldener, U., Langen, G., Pfiffi, S., et al., 2011. Endophyticlife strategies decoded by genome and transcriptome analyses of themutualistic root symbiont Piriformospora indica. PLoS Pathog. 7 (10),e1002290. http://dx.doi.org/10.1371/journal.ppat.1002290.

Supplementary Table 1.

Gene Name Annotation FPKMs

Pc_7749 Extracellular serine-rich protein 21.673,81Pc_11967 --- n/a --- 18.570,39Pc_11962 --- n/a --- 10.444,21Pc_2278 Protein 9.204,23Pc_11485 --- n/a --- 8.537,29Pc_1888 Ribonuclease h2 subunit a 7.984,88Pc_7036 Glycerol-3-phosphate dehydrogenase 7.950,15Pc_11345 Hypothetical protein maa_03842 6.230,70Pc_6526 Het domain protein 5.665,86Pc_861 Threonine 4.901,04Pc_11563 --- n/a --- 4.805,54Pc_4048 Methionine aminopeptidase 4.547,77Pc_630 Vesicle transport v-snare protein 3.877,25Pc_3724 Mitochondrial phosphate carrier protein 3.857,54Pc_9913 Arginase 3.790,07Pc_11098 Transcription factor cys6 3.416,71Pc_83 Yt521-b-like splicing 3.374,42Pc_11890 --- n/a --- 3.338,17Pc_2434 Predicted protein 2.931,17Pc_8735 Ct20 family protein 2.870,60Pc_9768 Atp-dependent dna helicase srs2 2.667,99Pc_1843 Ribosome biogenesis atpase rix7 2.606,03Pc_7096 Glutaredoxin 2.478,11Pc_5502 Hypothetical protein mac_00536 2.461,13Pc_9611 Biotin lipoate a b protein ligase 2.429,13Pc_2639 Pisatin demethylase 2.326,67Pc_11681 --- n/a --- 2.278,19Pc_12088 --- n/a --- 2.055,95Pc_10104 An1-type zinc finger protein 2.001,13Pc_1587 Secreted serine protease 1.983,14Pc_7112 Glutaminyl-trna synthetase 1.962,60Pc_2935 Peptide-n4-(n-acetyl-beta-glucosaminyl)asparagine amidase a 1.961,32Pc_2000 Ras gtpase-activating protein 1.920,40Pc_9349 C6 transcription factor 1.912,96Pc_10816 40s ribosomal protein s16 1.896,41Pc_8976 Checkpoint kinase 2-like protein 1.805,78Pc_5846 Hypothetical protein maa_04284 1.805,42Pc_8386 Dihydrolipoyllysine-residue succinyltransferase 1.763,17Pc_11708 --- n/a --- 1.757,13Pc_2436 Predicted protein 1.724,91Pc_9171 Carboxypeptidase 1.712,39Pc_1850 Ribosomal rna-processing protein 1.692,83Pc_310 Vacuolar amino acid transporter 1 1.678,19Pc_7433 Formate dehydrogenase 1.659,65Pc_2168 Protein kinase-like domain 1.631,25Pc_8910 Chromosome segregation in meiosis protein 3 1.621,86

RNA-Seq analysis of genes expressed by P. chlamydosporia during barley root endophytic colonization

Pc_2479 Pre-rrna-processing protein esf2 1.611,20Pc_1461 Serine-type carboxypeptidase 1.603,29Pc_3429 Nadp-dependent leukotriene b4 12-hydroxydehydrogenase 1.579,82Pc_8628 Cytochrome b5 1.575,84Pc_8627 Cytochrome b5 1.514,40Pc_6161 Hypothetical protein foxb_00180 1.514,02Pc_5243 Hypothetical protein mac_05032 1.494,29Pc_11886 ---n.a.--- 1.485,16Pc_11567 ---n.a.--- 1.464,49Pc_9035 Cell wall glucanase 1.448,78Pc_6448 High-affinity glucose transporter rgt2 1.418,84Pc_3451 Nadh-ubiquinone oxidoreductase kda subunit 1.411,72Pc_1204 Sorbitol dehydrogenase 1.394,41Pc_5313 Hypothetical protein mac_03831 1.367,31Pc_1155 Spt3-like protein 1.354,18Pc_10721 60s ribosomal protein l27a 1.350,34Pc_5098 Hypothetical protein mac_07384 1.342,67Pc_5796 Hypothetical protein maa_05146 1.309,68Pc_445 Ubiquitin metalloprotease fusion protein 1.285,86Pc_2771 Phosphatidylserine phosphatidylglycerophosphate cardiolipinsynthase-like 1.278,01Pc_509 U1 small nuclear ribonucleoprotein 1.274,56Pc_782 Tetratricopeptide tpr_2 repeat protein 1.274,01Pc_85 Efflux pump antibiotic resistance protein 1.265,10Pc_2279 Protein 1.256,69Pc_7744 F-box and domain 1.254,27Pc_11325 Hypothetical protein maa_07153 1.247,80Pc_4190 Malate synthase 1.212,43Pc_11150 Predicted protein 1.206,78Pc_4128 Mediator subunit med1 1.193,37Pc_7600 Family protein 1.192,47Pc_10385 Alcohol dehydrogenase 1.173,06Pc_7545 Fatty acid-binding protein 1.171,36Pc_11445 Conserved hypothetical protein 1.167,97Pc_754 Transcription factor btf3a 1.167,41Pc_11790 ---n.a.--- 1.114,75Pc_7111 Glutaminyl-trna synthetase 1.101,56Pc_208 Voltage-gated k channel beta 1.089,53Pc_6987 Glycoside hydrolase family 17 protein 1.061,43Pc_8978 Chch domain protein 1.054,12Pc_8912 Chromosome 10 open reading frame 76 1.045,33Pc_8714 Cupin domain-containing protein 1.030,26Pc_5314 Hypothetical protein mac_03795 1.020,83Pc_5529 Hypothetical protein mac_00240 1.013,78Pc_3997 Methyltransferase type 12 1.012,87Pc_4324 Lipase esterase family 995,63Pc_7537 Fe-s protein assembly co-chaperone 989,29Pc_10821 40s ribosomal protein s11 988,36Pc_8568 Cytochrome p450 978,66Pc_2961 Peptidase family m28 973,95Pc_1815 Ring finger protein 965,48Pc_419 Ubiquitin-like modifier 950,78

Pc_801 Protein alcs 941,38Pc_183 Rik1-associated factor 1 936,36Pc_8764 Copper amine oxidase 932,46Pc_10301 Allergen asp f4-like protein 918,56Pc_5226 Hypothetical protein mac_05340 916,95Pc_5361 Hypothetical protein mac_03059 911,73Pc_10227 Alpha-mannosidase 1a 906,59Pc_10460 Acyltransferase, putative 899,68Pc_10803 40s ribosomal protein s28 898,45Pc_10854 3-phytase a precursor 896,32Pc_10716 60s ribosomal protein l33 859,31Pc_5784 Hypothetical protein maa_05352 856,68Pc_8982 Cfem domain-containing protein 836,99Pc_11889 ---n.a.--- 821,54Pc_11792 ---n.a.--- 817,69Pc_5195 Hypothetical protein mac_05842 802,34Pc_8760 Coproporphyrinogen iii oxidase 798,98Pc_7495 Fkbp-type peptidyl-prolyl 790,89Pc_4402 L-galactose dehydrogenase 773,41Pc_5912 Hypothetical protein maa_03299 771,08Pc_11773 --- n/a --- 760,68Pc_3867 Mfs transporter 756,97Pc_7194 General substrate transporter 753,23Pc_5399 Hypothetical protein mac_02290 750,19Pc_7118 Glutamine amidotransferase subunit pdxt 747,81Pc_6282 Hydrophobin 739,06Pc_1351 Rhamnolipids biosynthesis 3-oxoacyl- 730,20Pc_10728 60s ribosomal protein l21 729,14Pc_8855 Coatomer subunit epsilon 716,09Pc_4063 Metalloprotease 712,44Pc_2061 Pyridoxine biosynthesis protein 702,32Pc_9151 Carrier protein 701,20Pc_8698 Cutinase transcription factor 1 alpha 683,61Pc_2114 Protein-beta-aspartate methyltransferase 679,56Pc_2897 Peroxisomal catalase 674,55Pc_2455 Predicted protein 672,15Pc_6990 Glycoside hydrolase family 16 protein 666,61Pc_3895 Mfs quinate 652,85Pc_10085 Ankyrin and het domain protein 651,99Pc_11933 --- n/a --- 651,56Pc_1031 Sulfate permease 2 651,13Pc_2786 Phosphatidylglycerol phosphatidylinositol transfer protein precursor 638,79Pc_6042 Hypothetical protein maa_01046 636,67Pc_2124 Protein transport protein 635,71Pc_136 Woronin body major protein 633,19Pc_4898 Hypothetical protein teqg_05663 633,12Pc_8922 Chromatin modifying protein 1b 631,67Pc_2025 Rab gtpase 631,00Pc_8850 Cofilin tropomyosin-type actin-binding protein 628,54Pc_6009 Hypothetical protein maa_01785 625,19Pc_5568 Hypothetical protein maa_09767 621,71

Pc_9948 Annexin a7 620,12Pc_9894 Argininosuccinate synthase 616,56Pc_3777 Mitochondrial cytochrome 613,79Pc_7150 Glucose transporter 609,33Pc_10220 Alternative nadh-dehydrogenase 604,30Pc_9421 C6 transcription 601,63Pc_10825 4-nitrophenylphosphatase 593,80Pc_10366 Aldehyde dehydrogenase 593,56Pc_1273 Small nuclear ribonucleoprotein 592,38Pc_9162 Carboxypeptidase y precursor 588,64Pc_7880 Epoxide hydrolase 587,11Pc_4140 Mediator complex subunit med18 585,50Pc_90 Yip1 domain family 583,85Pc_11838 --- n/a --- 583,48Pc_2819 Phenylacetyl- ligase 582,39Pc_9205 Carbon response regulator 570,63Pc_4199 Major facilitator superfamily transporter sugar 567,23Pc_4282 Lysozyme 565,33Pc_8456 Decapping enzyme 563,75Pc_11090 Uncharacterized protein cpur_02853 559,31Pc_10726 60s ribosomal protein l23 558,35Pc_8138 Dss1 sem1 family protein 557,35Pc_2486 Pre-mrna-splicing factor slu7 552,26Pc_9269 Calcipressin family protein 548,29Pc_9059 Cell division control protein cdc48 547,25Pc_4876 Hypothetical protein triatdraft_231249 546,53Pc_11302 Hypothetical protein maa_10533 545,59Pc_10453 Adenine phosphoribosyltransferase 542,23Pc_11144 Protein 540,43Pc_10497 Acyl carrier protein 539,95Pc_10109 Amp dependent ligase 539,71Pc_6385 Histone deacetylase phd1 533,62Pc_4702 Inner membrane magnesium transporter mrs2 530,30Pc_3000 Pbs lyase heat domain protein repeat-containing protein 527,55Pc_6841 Glycosyl hydrolase family 61 522,55Pc_10103 Anaphase promoting complex subunit 10 521,60Pc_2851 Ph domain-containing protein 519,46Pc_549 Trypsin-like protease 516,75Pc_2889 Peroxisomal matrix protein 512,12Pc_5689 Hypothetical protein maa_07071 510,19Pc_10737 60s ribosomal protein l16 509,56Pc_4524 Isocitrate lyase 507,56Pc_10964 2-nitropropane dioxygenase 506,42Pc_9023 Cell wall protein 506,15Pc_7432 Forms a complex with the other rrn protein rrn6 and rrn11 500,33Pc_7080 Glutathione s-transferase 496,88Pc_2316 Protein 495,55Pc_11744 --- n/a --- 491,03Pc_8103 Duf1682 domain protein 491,03Pc_4332 Lipase 2 489,96Pc_1119 Stress-activated map kinase 488,98

Pc_11249 Hypothetical protein mac_09045 485,49Pc_5806 Hypothetical protein maa_04994 485,09Pc_6539 Het domain protein 484,90Pc_1004 Sur7 protein 483,52Pc_3554 N-glycosylase dna lyase 483,47Pc_4392 L-xylulose reductase 481,94Pc_487 Ef hand domain protein 481,77Pc_10813 40s ribosomal protein s19 480,80Pc_6084 Hypothetical protein maa_00048 480,36Pc_971 Transcription initiation factor tfiid complex 60 kda subunit 476,81Pc_2775 Phosphatidylinositol:udp- c transferase pig-c 475,65Pc_10812 40s ribosomal protein s2 469,93Pc_7000 Glycoside hydrolase family 12 protein 464,99Pc_4283 Lysosomal protective protein 464,70Pc_448 Ubiquitin c-terminal hydrolase family protein 459,82Pc_6264 Hypothetical hrq family protein 1 455,44Pc_8060 Duf408 domain protein 450,26Pc_7412 Fumarate hydratase 448,77Pc_8613 Cytochrome c oxidase polypeptide v 447,71Pc_10662 Aar2 protein 444,71Pc_1197 Spc97 spc98 family protein 444,68Pc_4242 Major facilitator superfamily transporter 443,88Pc_1490 Serine threonine-protein kinase sck1 442,74Pc_10209 Amidase family protein 440,21Pc_3694 Mitotic spindle biogenesis protein 439,46Pc_7817 Eukaryotic translation initiation factor 3 subunit 8 438,42Pc_2916 Perilipin mpl1-like protein 436,99Pc_1171 Splicing factor 3b subunit 4 436,83Pc_7059 Glutathione-dependent formaldehyde dehydrogenase 427,46Pc_193 Wd domain containing protein 427,10Pc_6315 Hsc70 cochaperone 425,15Pc_9209 Carbohydrate-binding module family 48 protein 420,31Pc_4393 L-threonine 3-dehydrogenase 418,42Pc_5721 Hypothetical protein maa_06353 418,14Pc_7948 Elongation factor 1-gamma 416,72Pc_7026 Glycine dehydrogenase 412,85Pc_5120 Hypothetical protein mac_07090 410,84Pc_7806 Eukaryotic translation initiation factor 5b 410,13Pc_5181 Hypothetical protein mac_06133 409,19Pc_9016 Cell wall protein 409,19Pc_1884 Ribonuclease p subunit pop7 409,19Pc_9346 C6 transcription factor 408,58Pc_8486 D-tyrosyl-trna deacylase 407,87Pc_10152 Amino acid permease 407,08Pc_8245 Dna-binding wrky domain-containing protein 406,13Pc_10116 Ammonium permease 405,73Pc_4691 Inorganic pyrophosphatase 403,24Pc_8196 Domain containing protein 403,14Pc_8879 Clathrin coat assembly protein ap19 401,62Pc_7538 Fe-s cluster assembly protein dre2 398,96Pc_6208 Hypothetical protein bba_03274 395,85

Pc_10142 Amino-acid n-acetyltransferase subunit 394,93Pc_1254 Small secreted protein 394,29Pc_1871 Ribose-phosphate pyrophosphokinase 391,09Pc_3577 Mynd finger family protein 386,10Pc_9623 Bifunctional catalase-peroxidase cat2 385,81Pc_11819 --- n/a --- 384,46Pc_11206 Hypothetical protein trividraft_66658 374,48Pc_1469 Serine threonine-protein phosphatase pp1 373,94Pc_9712 Autophagy- ubiquitin-like modifier atg-12 373,61Pc_1721 Rnp domain-containing protein 373,25Pc_2521 Pre-mrna branch site protein p14 371,51Pc_333 Urease 370,93Pc_11197 Hypothetical protein vdag_04871 370,54Pc_10488 Acyl- dehydrogenase 366,22Pc_11757 --- n/a --- 365,26Pc_4569 Intermediate filament protein mdm1 364,81Pc_5913 Hypothetical protein maa_03296 364,02Pc_11132 Protein 359,81Pc_3409 Nap family protein 355,25Pc_3664 Monothiol glutaredoxin-4 351,75Pc_10389 Alcohol dehydrogenase 351,23Pc_1261 Small oligopeptide opt family 350,63Pc_565 Trna processing endoribonuclease 350,58Pc_306 Vacuolar atp synthase 16 kda proteolipid subunit 349,39Pc_10395 Alcohol dehydrogenase 348,88Pc_6741 Gnat family 348,23Pc_10798 40s ribosomal protein s4 346,72Pc_4643 Integral membrane protein 346,46Pc_4083 Metal-dependent amidase aminoacylase carboxypeptidase 346,20Pc_2475 Predicted protein 346,11Pc_1897 Riboflavin biosynthesis protein 346,01Pc_4265 Magnesium-dependent phosphatase 345,26Pc_3418 Nadph-adrenodoxin reductase arh1 344,59Pc_4134 Mediator of rna polymerase ii transcription subunit 31 343,72Pc_4112 Meiotically up-regulated protein 342,49Pc_10483 Acyl- desaturase 342,31Pc_7664 Fad binding domain-containing protein 339,67Pc_8690 Cyclic nucleotide-binding domain-containing protein 338,67Pc_5757 Hypothetical protein maa_05795 338,11Pc_10966 2-methylcitrate dehydratase 337,40Pc_1075 Peptidase 337,15Pc_10175 Amine oxidase 336,38Pc_309 Transmembrane amino acid transporter 336,35Pc_11522 --- n/a --- 336,32Pc_7422 Fructose- -bisphosphatase 336,30Pc_3789 Mitochondrial carrier protein leu5 335,21Pc_3238 Nuclear protein qri2 334,27Pc_31 Quinone oxidoreductase-like protein 2 like protein 333,70Pc_11541 --- n/a --- 333,58Pc_9094 Ccr4-not complex subunit caf16 331,66Pc_7180 Gliotoxin biosynthesis protein 331,59

Pc_1047 Sugar transporter stl1 331,41Pc_7129 Glutamate decarboxylase 330,24Pc_6360 Hit domain-containing protein 330,16Pc_3752 Mitochondrial import inner membrane translocase subunit tim-22 330,00Pc_9614 Biogenesis of lysosome-related organelles complex 1 subunit kxd1 327,13Pc_244 Valyl-trna synthetase 325,50Pc_10216 Amid-like mitochondrial oxidoreductase 325,05Pc_9344 C6 transcription factor 324,73Pc_2421 Prephenate dehydrogenase 323,69Pc_5692 Hypothetical protein maa_07025 323,64Pc_706 Transcriptional activator hac1 321,14Pc_2751 Phosphoglycerate mutase family protein 320,87Pc_9242 Calpain-like protein 318,04Pc_3332 Nitrilase cyanide hydratase 316,86Pc_7825 Eukaryotic translation initiation factor 3 315,87Pc_8870 Cleft lip and palate transmembrane protein 1 313,91Pc_10124 Aminopeptidase y 313,85Pc_8633 Cytochrome b-c1 complex subunit rieske 313,43Pc_1244 Snare complex subunit protein 313,16Pc_7418 Fructose-bisphosphate class ii 312,85Pc_11966 --- n/a --- 312,28Pc_6728 Gnat family 310,81Pc_5883 Hypothetical protein maa_03864 310,73Pc_804 Galactose oxidase precursor 310,73Pc_8183 Domain-containing protein 310,42Pc_4193 Malate dehydrogenase (nadp+) 310,10Pc_11717 --- n/a --- 306,90Pc_2246 Protein 306,90Pc_3311 Non-hemolytic phospholipase c 306,43Pc_6604 Haemolysin-iii channel protein 305,88Pc_580 Trna (adenine-n -)-methyltransferase 305,28Pc_6318 Hpp family protein 304,05Pc_1908 Rhodanese domain protein 303,70Pc_2799 Phosphate transporter 302,13Pc_5831 Hypothetical protein maa_04682 299,76Pc_2593 Polyketide 297,66Pc_4359 Leucine carboxyl methyltransferase family 295,56Pc_5790 Hypothetical protein maa_05222 295,41Pc_10648 Abc multidrug 293,99Pc_6317 Hrq family protein 293,89Pc_10985 14-3-3-like protein 292,05Pc_4364 Lem3 cdc50 family protein 291,87Pc_8778 Cop9 signalosome complex subunit 12 291,62Pc_10965 2-nitropropane dioxygenase 291,18Pc_5340 Hypothetical protein mac_03321 290,74Pc_6842 Glycosyl hydrolase family 47 protein 288,96Pc_4655 Integral membrane mpv17 pmp22 288,66Pc_5925 Hypothetical protein maa_03050 286,15Pc_6757 Glyoxalase bleomycin resistance protein dioxygenase 285,81Pc_1464 Serine-threonine rich protein 285,80Pc_11207 Hypothetical protein trividraft_66171 284,44

Pc_9154 Carnitine acetyl transferase 283,75Pc_5521 Hypothetical protein mac_00295 283,46Pc_1067 Sugar transporter 282,55Pc_10182 Amidohydrolase family protein 279,70Pc_2843 Ph-response regulator protein palc 279,69Pc_11359 Hypothetical protein maa_01484 279,00Pc_2447 Predicted protein 276,06Pc_8074 Duf250 domain membrane protein 275,67Pc_7905 Endosomal spry domain 275,21Pc_9831 Aspartate racemase 273,35Pc_4067 Metalloprotease 273,26Pc_11758 --- n/a --- 272,80Pc_10684 Pc20g14050 272,80Pc_1271 H aca ribonucleoprotein complex subunit 2 271,62Pc_2306 Protein 271,14Pc_6536 Het domain protein 270,74Pc_5323 Hypothetical protein mac_03640 270,25Pc_10877 3-ketoacyl- thiolase 269,36Pc_5027 Hypothetical protein mac_09045 268,93Pc_8432 Deoxyribose-phosphate aldolase 268,39Pc_1118 Stress activated map kinase interacting protein sin1 267,45Pc_6350 Hlh transcription factor 266,70Pc_2119 Protein transport protein sec61 alpha subunit 266,36Pc_2281 Protein 265,56Pc_9100 Ccch zinc finger and rrm domain-containing protein 263,78Pc_2067 Pyridoxal reductase 262,26Pc_11229 Hypothetical protein nechadraft_77883 261,48Pc_9608 Biotin synthase 261,16Pc_2087 Purine transporter 261,12Pc_8882 Class iii chitinase 2 260,95Pc_851 Thymidylate synthase 259,61Pc_9250 Calcium-binding protein precursor cnx1 259,58Pc_4527 Isocitrate dehydrogenase subunit 2 257,09Pc_8440 Delta12 fatty acid desaturase 257,01Pc_6394 Histone acetyltransferase subunit 256,31Pc_3844 Mfs transporter 256,01Pc_5482 Hypothetical protein mac_00937 255,37Pc_557 Trna-specific adenosine deaminase 255,31Pc_3034 Palmitoyltransferase erf2 255,13Pc_8610 Cytochrome c oxidase subunit 254,96Pc_2274 Protein 254,50Pc_9087 Cdp-alcohol phosphatidyltransferase 254,14Pc_8274 Dna repair protein rad51 253,35Pc_5018 Hypothetical protein mac_09137 253,35Pc_1749 Rna polymerase rpb1 repeat domain protein 252,43Pc_8624 Cytochrome c 252,40Pc_10758 6-phosphogluconate dehydrogenase 252,27Pc_5697 Hypothetical protein maa_06909 251,81Pc_4154 Mas3 protein 251,76Pc_2929 Peptidyl-prolyl cis-trans isomerase 251,72Pc_6255 Hypothetical protein akaw_02933 250,79

Pc_2978 Pentatricopeptide repeat protein 250,74Pc_902 Thiamine pyrophosphokinase 250,67Pc_8749 Cral trio domain protein 250,26Pc_5265 Hypothetical protein mac_04679 249,80Pc_11018 -like family protein 248,94Pc_7228 Gcn5-related n-acetyltransferase 246,88Pc_11513 --- n/a --- 246,57Pc_3014 Parasitic phase-specific protein psp-1 246,35Pc_3920 Mfs multidrug 246,22Pc_3812 Mismatched base pair and cruciform dna recognition 246,19Pc_1885 Ribonuclease p protein subunit p29 246,06Pc_9599 Branched-chain amino acid aminotransferase 245,52Pc_10491 Acyl- dehydrogenase 244,97Pc_1547 Serine hydroxymethyltransferase 243,85Pc_9125 Catalytic protein 243,57Pc_9103 Ccaat-binding complex subunit hap2 243,11Pc_8868 Clock controlled protein 241,88Pc_2911 Peroxin 14 17 241,38Pc_8658 Cystathionine beta-synthase 241,38Pc_11481 --- n/a --- 241,28Pc_1993 Ras-2 protein 240,86Pc_6999 Glycoside hydrolase family 13 protein 240,57Pc_9504 C2h2 transcription factor 239,87Pc_87 Chromatin-remodeling complex subunit ies6 239,65Pc_874 Thioredoxin-like protein 238,85Pc_3366 Neutral trehalase 238,70Pc_3095 Oxalate decarboxylase 238,37Pc_1433 Sh3 domain-containing protein 237,96Pc_5263 Hypothetical protein mac_04748 237,87Pc_3654 Mrna binding post-transcriptional regulator 237,51Pc_2875 Peroxysomal citrate synthase 237,09Pc_5463 Hypothetical protein mac_01297 236,19Pc_1536 Serine threonine protein 235,85Pc_52 Zinc finger protein zpr1 235,48Pc_392 Udp-glucose 6-dehydrogenase 234,20Pc_490 U6 snrna-associated sm-like protein lsm3 233,51Pc_3663 Monothiol glutaredoxin-5 232,14Pc_4 Zn-dependent hydrolases of the beta-lactamase 231,35Pc_4041 Methionine-r-sulfoxide reductase 230,55Pc_9172 Carboxypeptidase 230,34Pc_6128 Hypothetical protein foxb_10273 229,95Pc_3041 Paf-acetylhydrolase family member 229,90Pc_775 Fact complex subunit spt-16 229,88Pc_7068 Glutathione s-transferase 229,46Pc_919 Tetratricopeptide repeat protein 1 229,42Pc_9795 Atp synthase f0 229,38Pc_9988 Ankyrin repeat-containing 229,37Pc_543 Tsa family protein 228,93Pc_10774 50s ribosomal protein l24 227,98Pc_11531 --- n/a --- 227,59Pc_7015 Glycoside catalytic core 227,54

Pc_10776 50s ribosomal protein l14 226,84Pc_7764 Extracellular membrane 8-cysteine cfem 226,31Pc_8634 Cytochrome b-c1 complex subunit 8 225,83Pc_11145 Probable ribosomal protein cytosolic 225,52Pc_7559 Fatty acid desaturase 224,77Pc_6550 Heme steroid binding 224,75Pc_4453 Kinesin light chain 224,45Pc_7024 Glycine-rich protein 224,37Pc_11286 Hypothetical protein mac_03420 223,45Pc_7037 Glycerol-3-phosphate dehydrogenase 223,45Pc_6002 Hypothetical protein maa_01925 223,39Pc_2007 Ran gtpase activating protein 1 223,20Pc_3281 Nonspecific lipid-transfer mitochondrial precursor 222,83Pc_7438 Forkhead box protein l2 222,73Pc_3771 Mitochondrial distribution and morphology protein 222,53Pc_4813 Hypothetical protein trividraft_220134 222,11Pc_9222 Capsule polysaccharide biosynthesis protein 221,75Pc_748 Transcription factor cys6 221,01Pc_4881 Hypothetical protein triatdraft_132795 220,61Pc_11493 --- n/a --- 219,80Pc_11898 --- n/a --- 219,06Pc_423 Ubiquitin-conjugating enzyme e2-16 kda 217,94Pc_11927 --- n/a --- 217,80Pc_11668 --- n/a --- 216,63Pc_10949 20s-pre-rrna d-site endonuclease nob1 216,14Pc_5971 Hypothetical protein maa_02380 215,62Pc_7009 Glycoside hydrolase 215,57Pc_6610 Had superfamily 215,37Pc_9173 Carboxymuconolactone decarboxylase 215,14Pc_10474 Acyl- thioesterase ii 214,38Pc_11083 Xylitol dehydrogenase 214,25Pc_11756 --- n/a --- 213,21Pc_11401 Hypothetical protein bba_09957 212,95Pc_5642 Hypothetical protein maa_08144 212,95Pc_7268 G2 m phase checkpoint control protein 212,61Pc_7305 Fungal transcriptional regulatory protein 211,93Pc_2960 Peptidase family m28 211,53Pc_9314 C6 zinc finger domain protein 210,49Pc_9167 Carboxypeptidase y 210,25Pc_5060 Hypothetical protein mac_08273 210,16Pc_6984 Glycoside hydrolase family 18 protein 208,59Pc_3417 Nadph-cytochrome p450 reductase 208,14Pc_4418 L-arabinitol 4-dehydrogenase 207,87Pc_2936 Peptide transporter ptr2-a 207,79Pc_3638 Msf1 domain containing protein 206,36Pc_5771 Hypothetical protein maa_05526 206,11Pc_9506 C2h2 transcription factor 205,25Pc_10250 Alpha- -mannosyltransferase kre5 205,00Pc_9040 Cell wall biogenesis protein 204,60Pc_9816 Aspartyl-trna synthetase 204,37Pc_4842 Hypothetical protein trividraft_130235, partial 203,84

Pc_10767 54s ribosomal protein l12 203,47Pc_10799 40s ribosomal protein s3ae 203,01Pc_7135 Glucosyl glucuronosyl 202,64Pc_3934 Mfs multidrug 202,39Pc_2298 Protein 202,19Pc_9354 C6 transcription factor 201,70Pc_2462 Predicted protein 201,22Pc_11420 H k atpase alpha 200,63Pc_7607 Family 199,97Pc_435 Ubiquitin-conjugating enzyme 198,50Pc_9351 C6 transcription factor 198,09Pc_3144 Oligopeptide transporter 197,47Pc_11247 Hypothetical protein mac_09679 197,09Pc_1094 Probable subtilisin-like serine protease 196,81Pc_7691 Fad binding domain containing protein 196,37Pc_361 Upf0052 domain protein 195,68Pc_3442 Nadh:ubiquinone oxidoreductase subunit 194,73Pc_9834 Aspartate aminotransferase 194,62Pc_11700 --- n/a --- 194,07Pc_421 Ubiquitin-conjugating enzyme family protein 193,73Pc_277 Vacuolar protein sorting 55 superfamily 193,58Pc_513 Tyrosyl-trna synthetase 193,52Pc_1991 Ras-like protein 193,51Pc_3749 Mitochondrial import inner membrane translocase subunit tim-9 193,10Pc_221 Viral a-type inclusion protein repeat protein 192,32Pc_572 Trna exportin 192,26Pc_3733 Mitochondrial large ribosomal subunit 192,16Pc_5061 Hypothetical protein mac_08269 191,87Pc_9841 Asparagine synthetase domain containing protein 1 191,81Pc_9202 Carbon-nitrogen hydrolase 191,55Pc_1107 Subtilisin-like protease pr1a 191,41Pc_613 Transthyretin domain protein 190,65Pc_8062 Duf341 family 190,49Pc_11382 Hypothetical protein foxb_02649 190,19Pc_6836 Glycosyl transferase family 17 protein 190,16Pc_11729 --- n/a --- 189,82Pc_8233 Dna-directed rna polymerase iii 189,26Pc_7680 Fad binding domain protein 188,86Pc_2078 Px domain-containing protein 188,68Pc_3824 Microtubule-associated protein rp eb family member 1 188,67Pc_4312 Long-chain-fatty-acid- ligase 188,59Pc_539 Tubulin gamma chain 188,25Pc_3422 Nadph oxidase 188,22Pc_11764 --- n/a --- 187,75Pc_3898 Mfs peptide transporter 187,60Pc_8997 Centromere microtubule binding protein cbf5 187,19Pc_5308 Hypothetical protein mac_03918 187,10Pc_4027 Methylglutaconyl- hydratase 187,06Pc_7954 Electron transfer flavoprotein subunit alpha 186,96Pc_11044 --- n/a --- 186,81Pc_11462 C6 transcription 186,49

Pc_5364 Hypothetical protein mac_02995 186,33Pc_11261 Hypothetical protein mac_06932 186,12Pc_12101 --- n/a --- 184,64Pc_6978 Glycoside hydrolase family 18 protein 184,64Pc_2527 Pq loop repeat protein 184,48Pc_1064 High-affinity glucose transporter 184,46Pc_1990 Ras-related protein rab-11b 184,43Pc_9788 Atp synthase subunit alpha 184,25Pc_6731 Gnat family 183,89Pc_926 Tetraspanin 182,77Pc_6821 Glycosyltransferase family 2 protein 182,62Pc_9210 Carbohydrate-binding module family 48 protein 182,22Pc_144 Wd40 repeat protein 182,19Pc_8341 Dna damage response protein 182,16Pc_5478 Hypothetical protein mac_01021 182,10Pc_10464 Acylamide-delta3 -desaturase 181,81Pc_2419 Presequence translocase-associated motor subunit 181,44Pc_8370 Dimeric alpha-beta barrel 181,42Pc_1274 Small nuclear ribonucleoprotein 181,35Pc_10757 6-phosphogluconate dehydrogenase 2 181,35Pc_7829 Eukaryotic translation initiation factor 2 gamma subunit 181,02Pc_3164 O-methyltransferase 180,96Pc_6006 Hypothetical protein maa_01818 180,94Pc_4531 Isochorismatase family protein family 180,69Pc_12009 --- n/a --- 180,53Pc_8745 Cral trio domain protein 180,53Pc_8659 Cystathionine beta-synthase 180,26Pc_7914 Endopolygalacturonase 180,23Pc_682 Transcriptional repressor tup1 180,05Pc_10785 5-formyltetrahydrofolate cyclo-ligase 179,96Pc_8152 Dopa -dioxygenase 179,73Pc_5162 Hypothetical protein mac_06367 179,23Pc_1458 Serum paraoxonase arylesterase family protein 179,14Pc_11423 Glycoside hydrolase family 36 protein 178,87Pc_1676 S-adenosylmethionine synthetase 178,70Pc_8426 Developmental regulator 178,48Pc_5236 Hypothetical protein mac_05122 178,35Pc_7723 F-box domain-containing protein 178,32Pc_2807 Pho85 cyclin-1 178,10Pc_6560 Hec ndc80p family protein 177,40Pc_512 Tyrosyl-trna synthetase 177,35Pc_7203 General amino-acid permease gap1 177,32Pc_8843 Collagen-like protein mcl1 176,97Pc_5936 Hypothetical protein maa_02892 176,86Pc_11940 --- n/a --- 176,57Pc_11400 Hypothetical protein ccm_01595 176,38Pc_3617 Multidrug resistance protein 1 176,32Pc_8637 Cytidine deaminase 176,18Pc_10560 Acetylornithine deacetylase 176,07Pc_1636 Sap domain-containing protein 175,86Pc_4855 Hypothetical protein triatdraft_54026 175,37

Pc_3452 Nadh-ubiquinone oxidoreductase kda subunit 175,37Pc_6079 Hypothetical protein maa_00183 174,87Pc_3747 Mitochondrial import inner membrane translocase subunit tim8 174,45Pc_5405 Hypothetical protein mac_02230 174,22Pc_7934 Emp24 gp25l p24 family gold 173,71Pc_11826 --- n/a --- 173,51Pc_5194 Hypothetical protein mac_05860 173,17Pc_7055 Glutathione-dependent formaldehyde-activating enzyme 172,84Pc_11136 Protein 172,29Pc_1737 Rna splicing factor pad-1 172,12Pc_4008 Methyltransferase domain-containing protein 171,29Pc_8607 Cytochrome c1 171,03Pc_9927 Ap-3 adaptor complex subunit beta 170,62Pc_2106 Proteinase inhibitor kazal 170,50Pc_10958 2-oxoglutarate dehydrogenase e1 component 170,36Pc_7029 Glycine cleavage system h protein 170,09Pc_2115 Protein yop-1 169,70Pc_5082 Hypothetical protein mac_07695 169,66Pc_4957 Hypothetical protein nechadraft_50250 169,32Pc_8478 Dash complex subunit dad3 169,32Pc_2890 Peroxisomal hydratase-dehydrogenase-epimerase 169,32Pc_1532 Serine threonine protein kinase 169,24Pc_10557 Acetylserotonin methytransferase-like protein 169,02Pc_10888 3-hydroxyisobutyrate dehydrogenase 168,88Pc_6632 Guanine deaminase 168,83Pc_7284 G-patch domain-containing protein 168,35Pc_9883 Aromatic amino acid aminotransferase 168,01Pc_11712 --- n/a --- 167,92Pc_3588 Myb dna-binding domain protein 166,57Pc_2230 Protein hob3 166,33Pc_2736 Phospholipase a2 166,19Pc_11196 Hypothetical protein vdag_04871 165,96Pc_9047 Cell surface integral membrane mucin family 165,25Pc_4864 Hypothetical protein triatdraft_307656 164,88Pc_3809 Mitochondrial 18kda protein 164,68Pc_7468 Flavin-containing amine oxidase 164,61Pc_10007 Ankyrin repeat protein 164,20Pc_10977 2-dehydropantoate 2-reductase 163,20Pc_4146 Mboat family protein 162,50Pc_7471 Flavin-binding monooxygenase-like protein 162,30Pc_1073 Sucrose transport protein 162,29Pc_10517 Actin polymerization protein 162,23Pc_9724 Augmenter of liver regeneration 162,19Pc_1362 Short-chain dehydrogenase 162,13Pc_5974 Hypothetical protein maa_02350 162,09Pc_2116 Protein vts1 161,40Pc_10827 4-hydroxybenzoate polyprenyl transferase 161,12Pc_7808 Eukaryotic translation initiation factor 5 161,07Pc_3783 Mitochondrial chaperone bcs1 160,97Pc_8979 Charged multivesicular body protein 3 160,62Pc_5283 Hypothetical protein mac_04329 160,61

Pc_597 Tricarboxylate transporter mitochondrial carrier protein 160,56Pc_417 Ubiquitin-protein ligase 160,15Pc_3672 Monocarboxylate 160,06Pc_2044 Pyruvate kinase 159,99Pc_5051 Hypothetical protein mac_08532 158,93Pc_1835 Ribosome biogenesis protein rlp24 158,86Pc_389 Udp-n-acetylglucosamine-1-p transferase 158,65Pc_3199 Nucleosome assembly protein 158,32Pc_6579 Heat shock protein 70 157,38Pc_8073 Duf250 domain membrane protein 157,27Pc_4550 Iron copper transporter 156,86Pc_3107 Ornithine cyclodeaminase 155,95Pc_6651 Hypothetical protein mac_00410 155,88Pc_2501 Pre-mrna-processing atp-dependent rna helicase prp5 155,64Pc_9965 Ankyrin repeat-containing protein 155,49Pc_9989 Ankyrin repeat-containing 155,48Pc_10153 Amino acid permease 155,25Pc_9533 C2 domain-containing protein 155,02Pc_1905 Rhomboid family membrane protein 154,89Pc_1748 Rna polymerase rpb1 repeat domain protein 154,83Pc_46 Zinc cadmium resistance protein 154,62Pc_1109 Subtilisin-like protease 154,30Pc_8903 Chy and ring finger domain 154,06Pc_1360 Short-chain dehydrogenase oxidoreductase 154,02Pc_7721 F-box domain-containing protein 153,69Pc_988 Swr1-complex protein 4 153,68Pc_11316 Hypothetical protein maa_08709 153,45Pc_7257 Gaf domain nucleotide-binding protein 153,45Pc_8222 Dna-directed rna polymerases i ii iii subunit 10 153,45Pc_9563 Bzip transcription 152,71Pc_5765 Hypothetical protein maa_05647 152,58Pc_1001 Survival factor 1 152,48Pc_8420 Dhhc zinc finger membrane protein 152,43Pc_6442 High-affinity nicotinic acid transporter 152,26Pc_4321 Lipase thioesterase family protein 152,09Pc_4415 L-ascorbate oxidase 152,06Pc_9393 C6 transcription 151,90Pc_5108 Hypothetical protein mac_07253 151,01Pc_11040 -beta-glucanosyltransferase gel2 150,89Pc_7712 F-box domain-containing protein 150,85Pc_2848 Ph domain-containing protein 150,80Pc_10304 Allantoin catabolism protein 150,72Pc_11833 --- n/a --- 150,44Pc_8092 Duf1761-domain-containing protein 150,40Pc_8661 Cystathionine beta-lyase 150,37Pc_4197 Malate dehydrogenase 150,28Pc_11719 --- n/a --- 150,16Pc_1851 Ribosomal rna methyltransferase mrm2 149,72Pc_7313 Fungal transcriptional regulatory protein 149,64Pc_10848 37s ribosomal protein mrp17 149,58Pc_10371 Alcohol zinc- 149,30

Pc_7411 Fumarate hydratase 149,06Pc_5156 Hypothetical protein mac_06434 148,62Pc_10668 Aaa family 148,44Pc_1982 Regulator of g-protein signaling 148,31Pc_5377 Hypothetical protein mac_02668 147,90Pc_1421 Rhamnolipids biosynthesis 3-oxoacyl- 147,80Pc_10697 78 kda glucose-regulated protein 147,55Pc_4529 Isocitrate dehydrogenase 147,05Pc_7987 E3 ubiquitin-protein ligase hula 146,74Pc_10939 26s proteasome non-atpase regulatory subunit 8 146,61Pc_11260 Hypothetical protein mac_07219 145,37Pc_1337 Short-chain dehydrogenase reductase sdr 145,31Pc_7804 Eukaryotic translation initiation factor eif-1a 144,65Pc_5958 Hypothetical protein maa_02598 144,55Pc_4116 Meiotically up-regulated 65 protein 143,22Pc_10213 Amidase 143,03Pc_11651 --- n/a --- 143,02Pc_11813 --- n/a --- 142,94Pc_6744 Gmp synthase 142,41Pc_5599 Hypothetical protein maa_09159 142,22Pc_5709 Hypothetical protein maa_06684 142,08Pc_10264 Alpha partial 141,97Pc_11418 Het domain containing protein 141,64Pc_470 Ubiquitin carboxyl-terminal hydrolase 10 141,35Pc_4560 Intradiol ring-cleavage dioxygenase-like protein 141,33Pc_2303 Protein 141,26Pc_2171 Protein kinase-like domain 141,04Pc_498 U3 small nucleolar rna-associated protein 141,01Pc_4319 Lipid particle protein 140,69Pc_5992 Hypothetical protein maa_02078 140,65Pc_4978 Hypothetical protein mycgrdraft_41315 140,51Pc_3245 Nuclear pore complex subunit nup133 140,31Pc_4327 Lipase esterase 140,21Pc_9156 Cardiolipin synthetase 140,10Pc_6122 Hypothetical protein foxb_11984 139,58Pc_8731 Ctp synthase 139,55Pc_5815 Hypothetical protein maa_04928 139,33Pc_10278 Alpha beta hydrolase fold protein 139,20Pc_1560 Ser thr protein phosphatase family 138,72Pc_1050 Sugar transporter family protein 138,64Pc_3570 Myosin regulatory light chain cdc4 138,60Pc_4843 Hypothetical protein trividraft_129816, partial 138,53Pc_3242 Nuclear pore glycoprotein p62 138,38Pc_11104 Subunit iv of cytochrome c oxidase 138,26Pc_11063 --- n/a --- 138,18Pc_1567 Sequence orphan 137,79Pc_7106 Glutamyl-trna amidotransferase subunit a 137,52Pc_1089 Succinate dehydrogenase cytochrome b subunit 137,16Pc_2224 Protein kinase 136,98Pc_7895 Enoyl- hydratase isomerase 136,62Pc_12051 --- n/a --- 135,88

Pc_10526 Aconitate hydratase 135,83Pc_7635 Fad dependent oxidoreductase 135,73Pc_5021 Hypothetical protein mac_09104 135,66Pc_2235 Protein family upf0363 135,18Pc_5927 Hypothetical protein maa_03045 135,09Pc_2758 Phosphoglycerate kinase 135,09Pc_3714 Mitochondrial pyruvate dehydrogenase kinase 134,90Pc_10970 2-heptaprenyl- -naphthoquinone 134,67Pc_4656 Integral membrane mpv17 pmp22 134,27Pc_10021 Ankyrin repeat protein 134,13Pc_6719 Gnat family 134,08Pc_8434 Deoxyribodipyrimidine photo-lyase 134,07Pc_7870 Er membrane duf1077 domain 133,86Pc_6519 Het domain-containing protein 133,85Pc_9458 C6 finger domain-containing protein 133,58Pc_42 Adam protease adm-b 133,57Pc_4239 Major facilitator superfamily transporter 133,43Pc_11058 --- n/a --- 132,90Pc_6362 Histone-lysine n-methyltransferase set9 132,84Pc_5708 Hypothetical protein maa_06698 132,56Pc_1003 Surf4 family protein 132,55Pc_10689 Mfs transporter, putative 132,52Pc_6195 Hypothetical protein ch063_01429 131,69Pc_10181 Amidohydrolase family protein 131,53Pc_11743 --- n/a --- 131,10Pc_10963 2-nitropropane dioxygenase 130,67Pc_8162 Domain-containing protein 130,64Pc_2420 Translocation protein sec63 130,23Pc_3447 Nadh-ubiquinone oxidoreductase subunit 129,93Pc_8565 Cytochrome p450 129,73Pc_6919 Glycoside hydrolase family 5 protein 129,55Pc_3592 Myb dna-binding domain containing protein 129,53Pc_5305 Hypothetical protein mac_03954 129,35Pc_8005 Dynactin arp1 p62 subunit ro2 129,32Pc_5957 Hypothetical protein maa_02618 129,09Pc_927 Cytochrome p450 cyp542b3 128,99Pc_7057 Glutathione-dependent formaldehyde-activating 128,77Pc_6948 Glycoside hydrolase family 3 protein 127,87Pc_4313 Long-chain-fatty-acid- ligase 127,80Pc_2133 Protein required for cell viability rrp17 127,76Pc_8107 Duf1640-domain-containing protein 127,39Pc_9310 C6 zinc finger domain protein 126,51Pc_4001 Methyltransferase type 11 126,12Pc_511 U-box domain-containing protein 126,10Pc_2233 Protein fmp52-2 125,43Pc_8088 Duf185 domain-containing protein 125,26Pc_9353 C6 transcription factor 125,09Pc_293 Vacuolar atpase 125,03Pc_4613 Integral membrane protein 124,87Pc_5548 Hypothetical protein maa_10332 124,79Pc_10711 60s ribosomal protein l37a 124,75

Pc_6204 Hypothetical protein ccm_07398 124,73Pc_1832 Ribosome biogenesis protein urb1 124,71Pc_8657 Cystathionine gamma-lyase 124,52Pc_8629 Cytochrome b5 124,48Pc_4202 Major facilitator superfamily transporter 124,26Pc_1615 Sec14 cytosolic factor 124,22Pc_9326 C6 zinc finger domain protein 124,11Pc_11064 --- n/a --- 124,01Pc_10090 Dnaj domain containing protein 123,75Pc_3834 Mg2+ transporter 123,50Pc_5540 Hypothetical protein mac_00065 123,48Pc_857 Threonine synthase 123,44Pc_6138 Hypothetical protein foxb_06262 123,32Pc_9220 Carbamoyl-phosphate synthase 123,29Pc_8924 Chromatin assembly factor 1 subunit 122,93Pc_10518 Actin lateral binding protein 122,76Pc_6925 Glycoside hydrolase family 47 protein 122,14Pc_5821 Hypothetical protein maa_04855 122,03Pc_10146 Amino acid transporter 121,87Pc_2122 Protein transport protein sec22 121,51Pc_5481 Hypothetical protein mac_00969 121,49Pc_4573 Interferon-induced gtp-binding protein mx 121,38Pc_2404 Proline oxidase 121,18Pc_10478 Acyl- sterol acyltransferase 121,13Pc_4119 Meiotic recombination protein dmc1 120,97Pc_1874 Ribose-phosphate pyrophosphokinase 120,54Pc_1668 S33 family peptidase 120,53Pc_2019 Rad4 family protein 120,43Pc_4047 Methionine aminopeptidase 120,32Pc_9308 C6 zinc finger domain protein 120,31Pc_11500 --- n/a --- 120,15Pc_9184 Carboxylesterase family protein 119,96Pc_10159 Amino acid 119,94Pc_4798 Hypothetical protein trividraft_47845 119,88Pc_9707 Autophagy-related protein 9 119,47Pc_9627 Bicyclomycin resistance 119,35Pc_7782 Exosome complex exonuclease rrp41 119,16Pc_6348 Hmg box protein 119,01Pc_1320 Siderophore iron transporter 118,97Pc_11919 --- n/a --- 118,80Pc_10747 60s ribosomal protein 118,57Pc_9695 Basic leucine zipper transcription factor domain-containing protein 118,50Pc_8033 Duf757 domain-containing protein 118,32Pc_9071 Cell division control protein 118,28Pc_9727 Atpase family aaa domain-containing protein 1 118,22Pc_6052 Hypothetical protein maa_00792 118,04Pc_6710 Gns1 sur4 family protein 117,89Pc_6266 Hypothetical gmc oxidoreductase 117,83Pc_3709 Mitochondrial ribosomal protein subunit s4 117,65Pc_297 Vacuolar atp synthase subunit d 117,58Pc_5779 Hypothetical protein maa_05402 117,53

Pc_1638 Sam-dependent methyltransferase 117,27Pc_9882 Aromatic ring-opening dioxygenase 117,18Pc_669 Translation factor 117,06Pc_889 Thioesterase family protein 116,91Pc_555 Trna-splicing endonuclease 116,91Pc_11004 -trans-enoyl- isomerase 116,91Pc_3431 Nadp-dependent glycerol dehydrogenase 116,82Pc_2557 Polysaccharide synthase 116,64Pc_4528 Isocitrate dehydrogenase subunit 1 116,60Pc_8150 Dor1-like family protein 116,28Pc_11374 Hypothetical protein foxb_17176 116,25Pc_8146 Drug resistance protein 116,17Pc_1844 Ribosome assembly protein rrb1 116,12Pc_5023 Hypothetical protein mac_09104 115,87Pc_1762 Rna polymerase ii subunit 3 115,84Pc_2093 Pul domain-containing protein 115,75Pc_4043 Methionine type 115,49Pc_1860 Ribosomal protein l28e 114,84Pc_759 Transcription factor atf21 114,79Pc_8649 Cysteine dioxygenase 114,39Pc_11336 Hypothetical protein maa_05134 114,32Pc_2121 Protein transport protein sec24 114,09Pc_2355 Protein 114,08Pc_10829 4-hydroxyacetophenone monooxygenase 113,65Pc_8098 Duf1716 domain-containing protein 113,59Pc_4668 Integral membrane 113,52Pc_11647 --- n/a --- 113,18Pc_1973 Regulatory protein cys-3 113,18Pc_9520 C2h2 finger domain protein 112,67Pc_6056 Hypothetical protein maa_00723 112,60Pc_4424 L-allo-threonine aldolase 112,56Pc_5457 Hypothetical protein mac_01426 112,50Pc_10114 Ammonium transporter 112,49Pc_10847 37s ribosomal protein mrp4 112,40Pc_5813 Hypothetical protein maa_04933 112,40Pc_4696 Ino80 chromatin remodeling complex ies1 112,38Pc_8197 Domain containing protein 111,89Pc_11751 --- n/a --- 111,85Pc_3735 Mitochondrial intermediate peptidase 111,67Pc_7060 Glutathione transferase 111,60Pc_1250 Smp-30 gluconolaconase lre-like region 111,60Pc_2162 Protein mak16 111,60Pc_2718 Phospholipid methyltransferase 111,34Pc_5301 Hypothetical protein mac_04038 111,22Pc_3126 Oligosaccharyltransferase subunit ribophorin ii 111,14Pc_1122 Stress responsive a b barrel domain protein 111,12Pc_8875 Clavaminate synthase-like protein 110,99Pc_8322 Dna mismatch repair 110,76Pc_696 Transcriptional elongation protein 110,68Pc_10800 40s ribosomal protein s30 110,68Pc_6798 Glycosyltransferase family 32 protein 110,13

Pc_5856 Hypothetical protein maa_04157 110,04Pc_1086 Succinate fumarate mitochondrial transporter 110,02Pc_7589 Family protein 110,02Pc_8028 Duf803 domain membrane protein 109,93Pc_6059 Hypothetical protein maa_00668 109,89Pc_2622 Plasma membrane zinc ion 109,83Pc_6268 Hypothetical conserved protein 109,61Pc_8349 Disulfide isomerase 109,61Pc_5855 Hypothetical protein maa_04168 109,39Pc_7579 Family protein 109,39Pc_11268 Hypothetical protein mac_05345 109,12Pc_11109 Siderochrome-iron 109,12Pc_6310 Hsp40 co-chaperone 108,85Pc_5381 Hypothetical protein mac_02607 108,84Pc_1310 Siderophore iron transporter 108,81Pc_453 Ubiquitin domain 108,77Pc_7119 Glutaminase 108,66Pc_6702 Golgi membrane protein 108,46Pc_7570 Far upstream element-binding protein 2 108,05Pc_796 Tpr domain protein 107,76Pc_712 Bromodomain-containing factor 1 107,72Pc_11453 C6 zinc finger domain-containing protein 107,68Pc_3373 Neutral amino acid 107,41Pc_10646 Abc multidrug 107,12Pc_10929 2og-fe oxygenase 106,82Pc_7982 Ebp domain 106,75Pc_2685 Phosphotransferase enzyme family protein 106,69Pc_5587 Hypothetical protein maa_09397 106,44Pc_8079 Duf221 domain-containing protein 106,26Pc_3217 Nucleolar protein nop58 106,17Pc_10417 Aflatoxin biosynthesis ketoreductase nor-1 105,91Pc_1825 Ring finger domain 105,83Pc_3227 Nuclease s1 105,83Pc_7861 Er-golgi snare complex subunit 105,50Pc_581 Trm112p-like protein 105,50Pc_9708 Autophagy-related protein 28 105,44Pc_3249 Nuclear pore complex 105,42Pc_5949 Hypothetical protein maa_02743 105,33Pc_1481 Serine threonine-protein kinase sgk2 105,26Pc_8265 Dna replication complex gins protein sld5 105,06Pc_2324 Protein 104,62Pc_4519 Isoflavone reductase family protein 104,56Pc_6923 Glycoside hydrolase family 47 protein 104,48Pc_6557 Helicase-like protein 104,25Pc_10094 And nb-arc domain protein 104,15Pc_9011 Cell wall protein 104,09Pc_2729 Phospholipase carboxylesterase 103,50Pc_5994 Hypothetical protein maa_01980 103,43Pc_10930 2og-fe oxygenase 103,39Pc_1542 Serine protein 103,22Pc_5978 Hypothetical protein maa_02267 103,06

Pc_6652 Gtp-binding protein rhoa 102,80Pc_2918 Peptidyl-trna hydrolase 2 102,75Pc_3040 Paired amphipathic helix protein 102,73Pc_8040 Duf636 domain-containing protein 102,30Pc_11272 Hypothetical protein mac_04956 102,30Pc_11245 Hypothetical protein mac_09727 101,77Pc_6178 Hypothetical protein caci_6815 101,69Pc_7488 Flavin-binding 101,62Pc_2229 Protein kinase 101,56Pc_6429 Histidine biosynthesis trifunctional protein 101,35Pc_5871 Hypothetical protein maa_04035 101,28Pc_5979 Hypothetical protein maa_02259 101,27Pc_1270 Small nuclear ribonucleoprotein e 101,24Pc_4331 Lipase 3 precursor 101,24Pc_10433 Adp-ribosylation factor 6 101,17Pc_5585 Hypothetical protein maa_09425 101,16Pc_11470 Ankyrin repeat domain 101,14Pc_9754 Atp-dependent rna helicase dbp3 101,11Pc_3204 Nucleoside-diphosphate-sugar 101,03Pc_4828 Hypothetical protein trividraft_203505 100,77Pc_9730 Atp-nad kinase 100,71Pc_53 Zinc finger protein yan 100,64Pc_3319 Nitroreductase family protein 100,62Pc_8096 Duf1742-domain-containing protein 100,15Pc_515 Tyrosyl-dna phosphodiesterase 100,15Pc_8094 Duf1754-domain-containing protein 100,03Pc_9043 Cell surface spherulin 4-like 100,00Pc_374 Universal stress protein 99,90Pc_9751 Atp-dependent rna helicase dbp9 99,80Pc_11661 --- n/a --- 99,74Pc_6473 Hexaprenyldihydroxybenzoate methyltransferase 99,63Pc_81 Zinc alcohol 99,58Pc_5302 Hypothetical protein mac_03976 99,53Pc_7784 Exosome complex exonuclease rrp 99,49Pc_6548 Hemerythrin hhe cation binding domain-containing protein 99,32Pc_6850 Glycosyl hydrolase 99,22Pc_1940 Response regulator-like protein 99,17Pc_2362 Proteasome subunit alpha type 6 99,08Pc_5973 Hypothetical protein maa_02367 98,96Pc_10675 A kinase anchor 98,72Pc_10041 Ankyrin repeat protein 98,63Pc_1945 Replication factor-a protein 98,51Pc_4021 Methyltransferase 98,38Pc_4390 La domain family 98,31Pc_5770 Hypothetical protein maa_05531 98,31Pc_4665 Integral membrane 98,21Pc_914 Tfiih basal transcription factor complex p47 subunit 98,08Pc_398 Udp-glc gal endoplasmic reticulum nucleotide sugar transporter 97,85Pc_4671 Integral membrane 97,82Pc_4087 Metal dependent phosphohydrolase 97,80Pc_11670 --- n/a --- 97,80

Pc_3506 Nad dependent epimerase 97,79Pc_2712 Phosphomannomutase 97,75Pc_1731 Rna-binding protein fus tls 97,69Pc_8038 Duf647 domain-containing protein 97,62Pc_8806 Conserved hypothetical protein 97,58Pc_7387 Fungal specific transcription 97,57Pc_1716 Rrna assembly protein 97,52Pc_10679 _thioesterase family 97,31Pc_4494 Kelch repeat protein 97,29Pc_11975 --- n/a --- 96,91Pc_54 Zinc finger protein rts2 96,72Pc_3015 Parasitic phase-specific protein psp-1 96,63Pc_3106 Ornithine decarboxylase 96,62Pc_6062 Hypothetical protein maa_00578 96,60Pc_2240 Protein cgi121 96,59Pc_8844 Coiled-coil domain-containing protein mtmr15 96,55Pc_3932 Mfs multidrug 96,54Pc_8346 Dna binding domain with preference for a t rich regions-like protein 96,53Pc_2512 Pre-mrna splicing factor atp-dependent rna helicase prp43 96,45Pc_6657 Gtp-binding protein 1 96,21Pc_1946 Replication factor c subunit 4 96,01Pc_7138 Glucose-regulated protein 95,75Pc_6135 Hypothetical protein foxb_08167 95,49Pc_2256 Protein 95,48Pc_7909 Endosomal p24b protein 95,48Pc_4918 Hypothetical protein pmaa_049260 95,41Pc_6627 Guanine nucleotide-binding protein alpha subunit 95,36Pc_961 Nedd8-like protein 95,27Pc_9732 Atp-dependent zn protease 95,18Pc_3160 O-methyltransferase family protein 94,99Pc_10482 Acyl- desaturase 1 94,92Pc_6763 Glyoxal oxidase precursor 94,80Pc_430 Ubiquitin conjugating enzyme 94,72Pc_9801 Atp gtp-binding 94,66Pc_1933 Retinoblastoma-binding protein 94,65Pc_10511 Actin-like protein 3 94,54Pc_9942 Antigenic cell wall 94,43Pc_2856 Pfs domain-containing protein 94,43Pc_12063 --- n/a --- 94,43Pc_11263 Hypothetical protein mac_06684 94,28Pc_9521 C2h2 finger domain protein 94,28Pc_6336 Homeoprotein 94,08Pc_5857 Hypothetical protein maa_04154 93,77Pc_8975 Checkpoint protein 93,74Pc_6828 Glycosyltransferase family 15 protein 93,47Pc_2051 Pyruvate dehydrogenase e1 component beta subunit 93,30Pc_10445 Adenylate kinase 93,21Pc_11643 --- n/a --- 93,19Pc_7502 Filament-forming protein 93,18Pc_1477 Serine threonine-protein phosphatase 2a activator 1 93,00Pc_8526 Cytochrome p450 monooxygenase 92,94

Pc_1335 Short-chain dehydrogenase 92,90Pc_10826 4-hydroxyphenylpyruvate dioxygenase 92,82Pc_1623 Scf complex subunit skp1 92,78Pc_5015 Hypothetical protein mac_09228 92,46Pc_7826 Eukaryotic translation initiation factor 3 92,42Pc_7031 Glycerophosphoryl diester phosphodiesterase 92,39Pc_9022 Cell wall protein 92,30Pc_866 Tho complex subunit 7 92,16Pc_2720 Phospholipid metabolism enzyme 92,10Pc_903 Thiamin pyrophosphokinase-related protein 91,89Pc_1812 Ring finger-like protein 91,83Pc_8454 Defective in cullin neddylation protein 1 91,74Pc_9217 S-formylglutathione hydrolase 91,74Pc_7464 Flavin-nucleotide-binding protein 91,72Pc_2932 Peptidoglycan-binding lysin domain 91,72Pc_3272 Ntf2 and rrm domain-containing protein 91,54Pc_11622 --- n/a --- 91,53Pc_7533 Ferric reductase 91,42Pc_10150 Amino acid permease family 91,34Pc_9826 Aspartic endopeptidase 91,33Pc_4006 Methyltransferase family protein 91,33Pc_318 Utp-glucose-1-phosphate uridylyltransferase 91,21Pc_6199 Hypothetical protein ccm_09194 91,18Pc_10905 3-carboxymuconate cyclase 90,76Pc_8076 Duf2347 superfamily protein 90,70Pc_9564 Bzip family transcription factor 90,62Pc_11193 Hypothetical protein vdag_04898 90,56Pc_8377 Dihydroxy-acid dehydratase 90,56Pc_2746 Phosphoglycerate mutase family protein 90,48Pc_5058 Hypothetical protein mac_08284 90,40Pc_8664 Cyclopropane-fatty-acyl-phospholipid synthase 90,26Pc_10221 Alternative nadh dehydrogenase 90,08Pc_4051 Metalloregulatory protein 90,07Pc_5477 Hypothetical protein mac_01023 89,97Pc_1187 Sphingosine kinase 89,91Pc_10857 3-oxoacyl-(acyl-carrier-protein) reductase 89,82Pc_5950 Hypothetical protein maa_02731 89,43Pc_7444 Fmn dependent 89,39Pc_181 Wd repeat containing protein 82 89,25Pc_728 Transcription initiation factor iia gamma chain 89,18Pc_3463 Nadh-ubiquinone oxidoreductase 21 kda subunit 89,05Pc_9750 Atp-dependent rna helicase ded1 88,97Pc_2545 Potassium channel 88,89Pc_10514 Actin-like atpase domain-containing protein 88,76Pc_284 Vacuolar membrane pq loop repeat protein 88,74Pc_7449 Fmhp 88,72Pc_1239 Snare domain-containing protein 88,66Pc_10931 2fe-2s iron-sulfur cluster binding domain protein 88,43Pc_3799 Mitochondrial carrier 88,08Pc_8516 Cytokinesis regulator 87,86Pc_9629 Betaine aldehyde dehydrogenase 87,86

Pc_5768 Hypothetical protein maa_05590 87,68Pc_3801 Mitochondrial atpase 87,68Pc_6666 Gtp cyclohydrolase 87,49Pc_2058 Pyrroline-5-carboxylate reductase 87,42Pc_7596 Family protein 87,19Pc_422 Sumo-conjugating enzyme ubc9 87,17Pc_1189 Sphingolipid long chain base-responsive protein lsp1 87,14Pc_3264 Nuclear distribution protein 87,09Pc_1133 Sterol esterase precursor 87,07Pc_2006 Ran-interacting mog1 protein 86,80Pc_10186 Amidohydrolase family protein 86,59Pc_8755 Cp2 transcription 86,56Pc_11746 --- n/a --- 86,48Pc_2245 Protein 86,45Pc_2221 Protein kinase 86,45Pc_7746 F-actin capping protein beta subunit 86,45Pc_6320 Homoserine o-acetyltransferase 86,45Pc_5930 Hypothetical protein maa_02977 86,44Pc_6502 Heterogeneous nuclear ribonucleoprotein hrp1 86,31Pc_4164 Mannosyl-oligosaccharide -alpha-mannosidase 86,30Pc_3689 Mmc protein 86,26Pc_5174 Hypothetical protein mac_06179 86,22Pc_8192 Domain protein 85,97Pc_8200 Dolichyl-phosphate-mannose-protein mannosyltransferase 2 85,91Pc_10210 Amidase 85,85Pc_7864 Er protein big1 85,75Pc_8807 Conserved hypothetical protein 85,68Pc_9868 Arrestin domain-containing protein 85,54Pc_353 Upf0187 domain membrane protein 85,28Pc_11473 Acyl- n-acyltransferase 85,18Pc_7220 Gcn5-related n-acetyltransferase 85,12Pc_11891 --- n/a --- 85,08Pc_5527 Hypothetical protein mac_00246 84,93Pc_5065 Hypothetical protein mac_08090 84,73Pc_5486 Hypothetical protein mac_00842 84,66Pc_5984 Hypothetical protein maa_02178 84,51Pc_9877 Arp2 3 complex 21 kda subunit 84,47Pc_9665 Beta-alanine synthase 84,40Pc_9755 Atp-dependent rna helicase dbp10 84,35Pc_10578 Acetyl xylanesterase 84,32Pc_3251 Nuclear movement protein nudc 84,12Pc_6383 Histone h1 84,08Pc_11141 Protein 83,96Pc_11039 -binding protein 83,88Pc_11203 Hypothetical protein trividraft_79854 83,87Pc_8310 Dna polymerase alpha catalytic 83,58Pc_2179 Protein kinase-like domain 83,53Pc_9371 C6 transcription factor 83,39Pc_5934 Hypothetical protein maa_02905 83,35Pc_125 Wsc domain-containing protein 83,35Pc_2201 Protein kinase domain-containing protein 83,30

Pc_1366 Short-chain dehydrogenase reductase family protein 83,00Pc_11906 --- n/a --- 82,94Pc_10611 Abc1 family protein 82,86Pc_2928 Peptidyl-prolyl cis-trans isomerase 82,84Pc_3850 Mfs transporter 82,55Pc_11979 --- n/a --- 82,50Pc_8836 Condensin subunit 82,49Pc_5204 Hypothetical protein mac_05739 82,48Pc_6396 Histone acetyltransferase sas2 82,45Pc_296 Vacuolar atp synthase subunit e 82,41Pc_1647 Salicylate hydroxylase 82,32Pc_10972 2-deoxy-d-gluconate 3-dehydrogenase 82,31Pc_1058 Sugar transporter 82,24Pc_3864 Mfs transporter 82,16Pc_9890 Argonaute sirna chaperone complex subunit arb1 82,10Pc_9359 C6 transcription factor 81,84Pc_11332 Hypothetical protein maa_06192 81,84Pc_9979 Ankyrin repeat-containing 81,70Pc_8158 Domain-containing protein 81,65Pc_348 Upf0326 protein hag1 81,65Pc_3033 Palmitoyltransferase pfa3 81,64Pc_2482 Pre-rrna processing protein 81,53Pc_8988 Cfem domain-containing protein 81,30Pc_12102 --- n/a --- 81,24Pc_2653 Phytanoyl- dioxygenase family protein 81,12Pc_8548 Cytochrome p450 61 81,07Pc_1301 Signal sequence receptor alpha chain 80,99Pc_1278 Rna recognition domain-containing protein 80,83Pc_547 Tryptophan synthase 80,76Pc_9814 Aspergillopepsin-2 80,76Pc_11166 Peptidase m23 80,60Pc_11238 Hypothetical protein mycth_2056329 80,41Pc_10706 60s ribosomal protein l8 80,31Pc_413 Ubiquitin-protein ligase sel1 80,09Pc_1383 Short-chain protein 80,06Pc_4774 Hypothetical protein tsta_066400 80,06Pc_979 T-complex protein 1 subunit epsilon 80,06Pc_1213 Sodium phosphate 80,02Pc_3788 Mitochondrial carrier protein rim2 79,99Pc_920 Tetratricopeptide repeat domain-containing protein 79,81Pc_3351 Nif domain protein 79,77Pc_11292 Hypothetical protein mac_02220 79,63Pc_6311 Hsp20-like chaperone 79,57Pc_2183 Protein kinase-like domain 79,41Pc_2385 Prolyl-trna synthetase 79,34Pc_10814 40s ribosomal protein s18 79,33Pc_4127 Mediator subunit med11 79,31Pc_4246 Major facilitator superfamily transporter 79,26Pc_7902 Enhancer of zeste 2 isoform a 79,26Pc_5953 Hypothetical protein maa_02664 79,15Pc_2971 Peptidase c14 79,13

Pc_194 Wd domain containing protein 79,12Pc_3697 Mitotic check point protein 79,07Pc_11917 --- n/a --- 79,00Pc_5225 Hypothetical protein mac_05362 78,93Pc_9311 C6 zinc finger domain protein 78,85Pc_10756 6-phosphogluconate dehydrogenase nad-binding protein 78,74Pc_9674 Beta- 78,72Pc_982 T-complex protein 1 subunit delta 78,72Pc_4012 Methyltransferase domain-containing protein 78,64Pc_3691 Miz zinc finger protein 78,53Pc_4637 Integral membrane protein 78,51Pc_10616 Abc-type fe3+ transport system 78,43Pc_9517 C2h2 finger domain-containing protein 78,23Pc_6405 Histidyl-trna mitochondrial precursor 78,16Pc_3495 Nad dependent epimerase dehydratase family protein 78,16Pc_364 Upf0041 domain protein 78,12Pc_2225 Protein kinase 77,91Pc_4630 Integral membrane protein 77,87Pc_720 Transcription initiation factor tfiid subunit 10 77,80Pc_227 Vhs domain-containing protein 77,78Pc_1782 Rna binding protein 77,78Pc_7859 Erv25 protein 77,77Pc_6075 Hypothetical protein maa_00243 77,75Pc_4014 Methyltransferase domain-containing protein 77,72Pc_3372 Neutral amino acid 77,61Pc_6512 Het-c 77,47Pc_5542 Hypothetical protein maa_10558 77,45Pc_1878 Ribonucleotide reductase inhibitor 77,35Pc_11250 Hypothetical protein mac_08521 77,32Pc_1295 Ww domain-containing protein 77,28Pc_10160 Amino acid 77,23Pc_553 Trp-like ion channel 77,21Pc_1456 Seryl-trna mitochondrial 77,02Pc_603 Triacylglycerol lipase 77,02Pc_8358 Dipeptidyl peptidase 76,84Pc_10618 Abc transporter transmembrane region 2 76,83Pc_9863 Arsenical pump-driving atpase 76,72Pc_10458 Acyltransferase, putative 76,55Pc_943 Tbp associated factor 76,47Pc_7489 Flavin-binding 76,41Pc_6773 Glycosyltransferase family 8 protein 76,39Pc_3984 Mfs 76,13Pc_2428 Prefoldin subunit 76,09Pc_617 Hat domain-containing protein 75,82Pc_8012 Duf895 domain protein 75,74Pc_8828 Conserved glutamic acid rich protein 75,74Pc_5911 Hypothetical protein maa_03306 75,71Pc_6397 Histone acetyltransferase gcn5 75,54Pc_9051 Cell polarity protein 75,22Pc_11747 --- n/a --- 75,16Pc_8772 Cop9 signalosome subunit 7 75,07

Pc_347 Upf0658 golgi apparatus membrane protein 75,07Pc_9246 Calcofluor white hypersensitive protein 75,05Pc_6243 Hypothetical protein aol_s00076g191 75,01Pc_7729 F-box domain protein 74,95Pc_8235 Dna-directed rna polymerase ii subunit rpb2 74,90Pc_8869 Cleft lip and palate transmembrane protein 1 74,76Pc_260 Vacuolar protein sorting-associated protein vps28 74,40Pc_6794 Glycosyltransferase family 34 protein 74,40Pc_1466 Serine threonine-protein phosphatase ppe1 74,40Pc_11548 --- n/a --- 74,40Pc_3953 Mfs monocarboxylate 74,40Pc_5778 Hypothetical protein maa_05410 74,37Pc_1902 Rhomboid protein 2 74,36Pc_10874 3-ketoacyl-acyl carrier protein 74,35Pc_537 Tubulin-specific chaperone 74,08Pc_4638 Integral membrane protein 74,05Pc_10840 37s ribosomal protein s9 73,97Pc_6435 Histidine acid phosphatase 73,95Pc_11371 Hypothetical protein glarea_04121 73,88Pc_5870 Hypothetical protein maa_04042 73,60Pc_1138 Cyclopentanone -monooxygenase 73,55Pc_8660 Cystathionine beta-lyase 73,37Pc_3022 Pap2 domain containing protein 73,27Pc_5390 Hypothetical protein mac_02429 73,16Pc_686 Transcriptional regulatory protein dep1 73,02Pc_2596 Polyamine transporter 1 72,90Pc_9892 Arginyl-trna synthetase 72,77Pc_6712 Gnat family n- 72,77Pc_5562 Hypothetical protein maa_09910 72,64Pc_3956 Mfs monocarboxylate 72,62Pc_2291 Protein 72,58Pc_5825 Hypothetical protein maa_04821 72,57Pc_7554 Fatty acid hydroxylase superfamily protein 72,51Pc_8387 Dihydrolipoyl dehydrogenase 72,42Pc_7707 F-box wd repeat-containing protein 72,32Pc_10722 60s ribosomal protein l27 72,21Pc_4129 Mediator of rna polymerase ii transcription subunit 8 72,21Pc_5249 Hypothetical protein mac_04946 72,21Pc_4726 Importin beta-5 72,21Pc_5961 Hypothetical protein maa_02533 71,96Pc_7841 Ethyl tert-butyl ether degradation 71,89Pc_6691 Gpi anchored serine-threonine rich protein 71,83Pc_7965 Efflux pump antibiotic resistance 71,71Pc_3464 Nadh-ubiquinone oxidoreductase 18 kda 71,66Pc_5276 Hypothetical protein mac_04420 71,61Pc_9973 Ankyrin repeat-containing 71,55Pc_2159 Protein mlo3-like protein 71,53Pc_3598 Multisynthetase complex auxiliary component p43 71,53Pc_6934 Glycoside hydrolase family 36 protein 71,50Pc_7566 Fas1 domain-containing protein 71,45Pc_1150 Squalene synthase 71,43

Pc_7216 Gdp-mannose transporter 71,41Pc_7879 Epoxide hydrolase 71,41Pc_8236 Dna-directed rna polymerase ii subunit rpb11 71,37Pc_11106 Sterol 24-c-methyltransferase 71,37Pc_6053 Hypothetical protein maa_00776 71,31Pc_1255 Small secreted protein 71,28Pc_3072 Oxysterol binding protein 71,16Pc_9252 Calcium-binding mitochondrial carrier protein aralar1 71,14Pc_7192 Gentisate -dioxygenase 70,93Pc_2900 Peroxisomal biogenesis factor 2 70,92Pc_1345 D-arabinitol 2-dehydrogenase 70,82Pc_2003 Rare lipoprotein a -like protein 70,82Pc_8282 Dna repair protein protein 70,78Pc_4645 Integral membrane protein 70,64Pc_3213 Nucleoporin nup189 70,52Pc_10858 3-oxoacyl-(acyl-carrier-protein) reductase 70,50Pc_9396 C6 transcription 70,49Pc_1869 Ribosomal biogenesis protein gar2 70,44Pc_3110 Ornithine aminotransferase 70,34Pc_10346 Aldo keto 70,31Pc_11865 --- n/a --- 70,21Pc_6779 Glycosyltransferase family 59 protein 69,98Pc_7823 Eukaryotic translation initiation factor 3 subunit 69,88Pc_126 Wsc domain-containing protein 69,82Pc_4249 Major facilitator superfamily transporter 69,68Pc_2065 Pyridoxal-phosphate dependent 69,66Pc_1283 Sister chromatid separation protein 69,62Pc_3720 Mitochondrial precursor protein import receptor tom70 69,55Pc_362 Upf0047 domain protein 69,54Pc_2548 Possible fad-binding protein 69,51Pc_647 Translocation protein sec66 69,44Pc_231 Vesicular integral-membrane protein vip36 69,24Pc_1710 Rrna processing protein 69,18Pc_1043 Sugar transporter-like protein 68,97Pc_10367 Aldehyde dehydrogenase 68,80Pc_8877 Clathrin light chain 68,79Pc_4427 Kynureninase 68,75Pc_8768 Copii vesicles protein 68,73Pc_3942 Mfs monocarboxylate transporter 68,68Pc_11466 Atp synthase alpha chain precursor 68,50Pc_6853 Glycosyl hydrolase 68,50Pc_1487 Serine threonine-protein kinase sgk2 68,45Pc_7385 Fungal specific transcription 68,37Pc_10049 Ankyrin repeat protein 68,33Pc_6735 Gnat family 68,20Pc_1996 Ras small monomeric 68,20Pc_11606 --- n/a --- 68,20Pc_2476 Pre-rrna-processing protein tsr2 68,20Pc_3381 Negative regulator of differentiation 1 68,02Pc_5233 Hypothetical protein mac_05160 67,87Pc_11483 --- n/a --- 67,84

Pc_286 Vesicle-mediated transporter vid24 67,79Pc_11532 --- n/a --- 67,62Pc_8210 Doa4-independent degradation protein 67,62Pc_540 Tubulin alpha chain 67,60Pc_2092 Pumilio domain-containing protein 67,58Pc_10743 60s ribosomal protein l10a 67,57Pc_11942 --- n/a --- 67,37Pc_3437 Nadh:ubiquinone oxidoreductase subunit 67,26Pc_6648 Gtp-binding protein ypt5 67,22Pc_134 Wsc domain 67,22Pc_8128 Duf1237 domain protein 67,21Pc_2429 Prefoldin subunit 67,13Pc_11673 --- n/a --- 67,08Pc_7299 Fungal zn binuclear cluster domain containing protein 67,05Pc_6474 Hex2 protein 66,77Pc_8451 Dehydrodolichyl diphosphate synthase 66,76Pc_10479 Acyl- n-acyltransferase 66,72Pc_6759 Glyoxalase bleomycin resistance protein dioxygenase 66,72Pc_9709 Autophagy-related protein 22 66,70Pc_1910 Rho-type gtpase-activating protein 66,61Pc_10382 Alcohol dehydrogenase 66,60Pc_10268 Alpha beta hydrolase fold-3 domain-containing protein 66,40Pc_8909 Chromosome segregation protein 66,32Pc_3786 Mitochondrial chaperone 66,31Pc_5674 Hypothetical protein maa_07383 66,27Pc_12038 --- n/a --- 66,25Pc_6273 Hydroxyproline-rich glycoprotein dz-hrgp 66,18Pc_5583 Hypothetical protein maa_09439 66,16Pc_7669 Fad binding domain protein 65,97Pc_2691 Phosphoserine phosphatase 65,90Pc_9842 Asparagine synthetase 65,88Pc_3550 N-terminal binuclear zn cluster-containing dna binding domain-containing p 65,83Pc_3533 Nacht and ankyrin domain protein 65,82Pc_574 Trna (uridine-2 -o-)-methyltransferase trm7 65,82Pc_4183 Maltase 65,80Pc_10200 Amidase protein 65,76Pc_4254 Major facilitator superfamily protein 65,67Pc_7939 Elongation factor tu 65,65Pc_1612 Sec23 sec24 family protein 65,57Pc_4551 Iq calmodulin-binding motif protein 65,57Pc_2749 Phosphoglycerate mutase family protein 65,42Pc_739 Ank-repeat protein mbp1 65,28Pc_10794 40s ribosomal protein s8 65,23Pc_8980 Chalcone-flavanone isomerase 65,20Pc_6619 Guanyl-specific ribonuclease f1 65,10Pc_1045 Sugar transporter stl1 65,08Pc_11309 Hypothetical protein maa_09807 64,99Pc_9925 Ap-3 complex subunit sigma 64,95Pc_1838 Ribosome biogenesis protein brx1 64,92Pc_2388 Prolyl aminopeptidase (secreted protein) 64,83Pc_2177 Protein kinase-like domain 64,61

Pc_271 Vacuolar protein sorting targeting protein pep1 64,61Pc_7697 Fact complex subunit pob3 64,61Pc_2397 Proline-rich early nodulin 64,61Pc_8655 Cystathionine gamma-synthase 64,48Pc_11022 -dimethylguanosine trna methyltransferase 64,47Pc_7827 Eukaryotic translation initiation factor 3 64,45Pc_5605 Hypothetical protein maa_09006 64,44Pc_2170 Protein kinase-like domain 64,33Pc_5155 Hypothetical protein mac_06481 64,30Pc_7595 Family protein 64,23Pc_8050 Duf580 domain protein 64,21Pc_4943 Hypothetical protein nechadraft_78423 64,17Pc_3603 Multiple ankyrin repeats single kh domain 64,17Pc_3736 Mitochondrial inner membrane translocase subunit tim44 64,14Pc_11986 --- n/a --- 64,13Pc_3135 Oligopeptide transporter opt-like protein 64,02Pc_1747 Rna polymerase rpb4 family protein 63,94Pc_5715 Hypothetical protein maa_06471 63,94Pc_9969 Ankyrin repeat-containing protein 63,94Pc_3892 Mfs quinate 63,83Pc_2540 Potassium sodium efflux p-type atpase 63,72Pc_6249 Hypothetical protein ani_1_2510074 63,67Pc_8773 Cop9 signalosome subunit 6 63,55Pc_491 U6 snrna-associated sm-like protein lsm6 63,50Pc_7431 Formyltetrahydrofolate deformylase 63,50Pc_11559 --- n/a --- 63,50Pc_6880 Glycoside hydrolase family 76 protein 63,50Pc_397 Udp-glucoronosyl and udp-glucosyl transferase family protein 63,45Pc_5073 Hypothetical protein mac_07867 63,28Pc_1953 Related to secretory pathway protein ysy6 63,18Pc_9229 Cap-gly domain-containing protein 63,15Pc_2598 Polyamine transport protein 63,11Pc_8893 Citrinin biosynthesis transcriptional activator 63,11Pc_8123 Duf1253 domain-containing protein 63,09Pc_10541 Acid 63,09Pc_3750 Mitochondrial import inner membrane translocase subunit tim-54 63,06Pc_2806 Phosducin 63,06Pc_5164 Hypothetical protein mac_06342 62,89Pc_9694 Bax inhibitor family protein 62,81Pc_1000 Swi snf complex protein 62,77Pc_7499 Fimbrin 62,76Pc_7802 Eukaryotic translation initiation factor subunit 62,63Pc_5347 Hypothetical protein mac_03226 62,56Pc_7766 Extracellular matrix protein precursor 62,42Pc_7751 Extracellular serine-rich protein 62,36Pc_249 Vacuole morphology and inheritance protein 62,27Pc_5691 Hypothetical protein maa_07042 62,13Pc_3117 Orf21 protein 62,11Pc_3701 Mitogen-activated protein kinase 62,07Pc_10396 Alanyl-trna synthetase 62,07Pc_4101 Membrane transporter 62,04

Pc_1937 Restless-like transposase 62,03Pc_1673 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand 61,62Pc_3152 Oligomeric golgi complex component 61,46Pc_2243 Protein arginine n-methyltransferase 3 61,38Pc_2441 Predicted protein 61,38Pc_6476 Heterokaryon incompatibility protein het-c 61,38Pc_5210 Hypothetical protein mac_05629 61,23Pc_9037 Cell wall cysteine-rich protein 61,12Pc_3094 Oxalate decarboxylase oxdc 61,11Pc_3456 Nadh-ubiquinone oxidoreductase 78 kda subunit 61,10Pc_7759 Extracellular scp domain-containing protein pry1 61,04Pc_5842 Hypothetical protein maa_04309 61,01Pc_4800 Hypothetical protein trividraft_37774 61,00Pc_2611 Poly -binding protein 60,98Pc_628 Transporter protein smf2 60,90Pc_8025 Duf821 domain-containing protein 60,86Pc_4612 Integral membrane protein 60,84Pc_8226 Dna-directed rna polymerase iii subunit rpc10 60,83Pc_5515 Hypothetical protein mac_00383 60,74Pc_2430 Prefoldin subunit 60,73Pc_2198 Protein kinase domain-containing protein ppk32 60,56Pc_10573 Acetyl- acetyltransferase 60,45Pc_7843 Ethanolamine utilization protein 60,37Pc_3785 Mitochondrial chaperone 60,34Pc_8283 Dna repair protein 60,33Pc_11910 --- n/a --- 60,28Pc_1821 Ring finger domain protein 60,28Pc_1537 Serine threonine protein 60,25Pc_9779 Atp-binding domain 1 family member b 60,21Pc_1228 Snf2-family atp dependent chromatin remodeling factor snf21 60,19Pc_946 Tbc1 domain family member 14 60,18Pc_387 Ulp1 protease family protein 60,13Pc_9079 Cell cycle control protein 60,07Pc_402 Udp- transferase 60,04Pc_7020 Glycogen phosphorylase 59,98Pc_7673 Fad binding domain protein 59,98Pc_7611 Fad-dependent oxygenase 59,95Pc_5139 Hypothetical protein mac_06787 59,94Pc_10838 4-aminobutyrate aminotransferase 59,92Pc_8472 Dcg1 protein 59,88Pc_8835 Conidiophore development protein hyma 59,72Pc_5134 Hypothetical protein mac_06802 59,65Pc_8739 Cript family protein 59,40Pc_1007 Suppressor of mek1 59,23Pc_3440 Nadh:ubiquinone oxidoreductase subunit 59,16Pc_1789 Rna binding effector protein 59,16Pc_3338 Nitrate reductase 59,11Pc_10439 Adenylyl-sulfate kinase 59,02Pc_1388 Carbonyl reductase 58,97Pc_9821 Aspartic-type endopeptidase 58,92Pc_8864 Coagulation factor 5 8 type domain protein 58,89

Pc_873 Thioredoxin-like protein 58,86Pc_3951 Mfs monocarboxylate 58,84Pc_6216 Hypothetical protein ccm_04991 58,77Pc_9130 Catalase 58,71Pc_4272 Mac1 interacting protein 1 58,66Pc_355 Upf0171 domain protein 58,63Pc_11935 --- n/a --- 58,46Pc_1368 Short-chain dehydrogenase 58,35Pc_8015 Duf890 domain-containing protein 58,27Pc_7494 Fkh1-like protein 58,21Pc_9721 Autophagocytosis protein 58,20Pc_7836 Eukaryotic initiation factor 4a-12 58,17Pc_1232 Snf2 family helicase 58,10Pc_6668 Gtp binding protein 58,09Pc_2481 Pre-rrna processing protein utp22 58,04Pc_3473 Nadh pyrophosphatase 57,96Pc_3186 Nudix domain-containing protein 57,95Pc_7824 Eukaryotic translation initiation factor 3 57,90Pc_8195 Domain protein 57,84Pc_4122 Meiosis-specific serine threonine-protein kinase mek1 57,78Pc_6032 Hypothetical protein maa_01235 57,76Pc_3795 Mitochondrial carrier protein 57,73Pc_8422 Dgpfaetke family protein 57,67Pc_4092 Merozoite capping protein-1 57,63Pc_3215 Nucleoporin nsp1 57,56Pc_169 Wd g-beta repeat containing protein 57,34Pc_8254 Dna replication licensing factor mcm7 57,32Pc_8080 Duf221 domain protein 57,25Pc_7208 General amidase 57,23Pc_10805 40s ribosomal protein s26e 57,22Pc_5701 Hypothetical protein maa_06788 57,22Pc_7737 F-box domain containing protein 57,03Pc_150 Wd-repeat protein 56,97Pc_8328 Dna kinase phosphatase pnk1 56,95Pc_4609 Integral membrane protein 56,80Pc_4011 Methyltransferase domain-containing protein 56,79Pc_4642 Integral membrane protein 56,79Pc_4592 Integral membrane protein 56,74Pc_11259 Hypothetical protein mac_07388 56,66Pc_5043 Hypothetical protein mac_08719 56,64Pc_1923 Reverse transcriptase 56,61Pc_415 Hect domain protein 56,56Pc_1823 Ring finger domain protein 56,50Pc_1765 Rna polymerase ii elongator subunit 56,49Pc_10287 Alpha beta hydrolase 56,44Pc_884 Thiopurine s-methyltransferase family protein 56,41Pc_410 Ubiquitination network signaling protein 56,31Pc_7820 Eukaryotic translation initiation factor 3 subunit 2 56,29Pc_5964 Hypothetical protein maa_02462 56,24Pc_4302 Low temperature requirement a protein 56,23Pc_6890 Glycoside hydrolase family 76 56,16

Pc_10959 2-oxoacid dehydrogenase acyltransferase 56,03Pc_9936 Anucleate primary sterigmata protein b 55,95Pc_9794 Atp synthase gamma chain 55,89Pc_867 Tho complex subunit 3 55,80Pc_5003 Hypothetical protein mac_09581 55,80Pc_3626 Iron transport multicopper oxidase fet3 55,71Pc_1642 Sam binding domain-containing protein containing protein 55,71Pc_3187 Nudix domain-containing protein 55,68Pc_10865 3-oxo-5-alpha-steroid 4- 55,62Pc_9534 C2 domain-containing protein 55,61Pc_89 Yippee family protein 55,59Pc_381 Uncharacterized membrane protein 55,47Pc_7184 Giy-yig catalytic domain-containing protein 55,42Pc_9494 C2h2 type zinc finger domain-containing protein 55,42Pc_5170 Hypothetical protein mac_06245 55,39Pc_544 Tryptophanyl-trna synthetase 55,33Pc_9444 C6 transcription 55,32Pc_9414 C6 transcription 55,25Pc_5198 Hypothetical protein mac_05816 55,12Pc_5720 Hypothetical protein maa_06390 55,10Pc_10357 Aldehyde dehydrogenase 55,08Pc_4526 Isocitrate lyase 55,07Pc_6302 Hsp70 nucleotide exchange factor 55,05Pc_3063 P-type atpase 55,01Pc_8579 Cytochrome p450 55,00Pc_18 Alcohol dehydrogenase 54,99Pc_11059 Uncharacterized protein cpur_07567 54,86Pc_4660 Integral membrane 54,85Pc_9061 Cell division control protein 3 54,74Pc_5591 Hypothetical protein maa_09291 54,70Pc_10995 1-aminocyclopropane-1-carboxylate deaminase 54,68Pc_5658 Hypothetical protein maa_07681 54,65Pc_10820 40s ribosomal protein s12 54,65Pc_7969 Efflux pump antibiotic resistance 54,56Pc_9990 Ankyrin repeat-containing 54,54Pc_7901 Enolase 54,53Pc_2056 Pyruvate carboxylase 54,51Pc_7604 Family decarboxylase 54,51Pc_255 Vacuolar sorting protein 1 54,36Pc_10916 3 exoribonuclease 54,36Pc_8441 Delta-aminolevulinic acid dehydratase 54,35Pc_6820 Glycosyltransferase family 20 protein 54,33Pc_9900 Arginine n-methyltransferase 2 54,28Pc_4766 Hypothetical protein vdag_06449 54,26Pc_1913 Rho protein gdp dissociation inhibitor containing protein 54,24Pc_9341 C6 transcription factor 54,23Pc_1836 Ribosome biogenesis protein mak21 54,16Pc_5753 Hypothetical protein maa_05852 54,10Pc_1349 Short-chain dehydrogenase reductase family 54,09Pc_9910 Arginase family protein 53,99Pc_8721 Cupin 2 domain-containing protein 53,84

Pc_7889 Enoyl- mitochondrial 53,76Pc_3348 Nima-interacting protein 53,65Pc_1723 Rnp domain containing protein 53,60Pc_7893 Enoyl- hydratase isomerase family protein 53,55Pc_1828 Ricin-type beta-trefoil lectin domain-containing protein 53,55Pc_229 Vesicle fusion factor nsfi 53,51Pc_5556 Hypothetical protein maa_10100 53,46Pc_5972 Hypothetical protein maa_02369 53,44Pc_11585 --- n/a --- 53,28Pc_9155 Carnitine acetyl transferase 53,25Pc_1837 Ribosome biogenesis protein kri1 53,24Pc_6902 Glycoside hydrolase family 72 protein 53,23Pc_899 Thioesterase domain containing protein 53,22Pc_9268 Calcium calmodulin-dependent protein 53,15Pc_2145 Protein phosphatase pp2a regulatory subunit a 53,12Pc_10317 Allantoate permease 53,10Pc_1272 U6 snrna-associated sm-like protein lsm5 53,04Pc_7271 G-protein coupled receptor protein 53,04Pc_8536 Cytochrome p450 alkane hydroxylase 53,00Pc_3153 Oligo- -glucosidase 52,93Pc_132 Wsc domain-containing protein 52,91Pc_10493 Acyl- dehydrogenase 52,91Pc_9809 Atp binding 52,89Pc_11278 Hypothetical protein mac_04207 52,86Pc_1845 Ribosome assembly protein rrb1 52,86Pc_7608 Fam96b-like protein 52,83Pc_3557 N-alkane-inducible cytochrome p450 52,77Pc_8671 Cyclohexanone monooxygenase 52,73Pc_6708 Golgi apyrase 52,72Pc_4211 Major facilitator superfamily transporter 52,69Pc_6764 Glycylpeptide n-tetradecanoyltransferase 52,69Pc_9199 Carbonic anhydrase 2 52,69Pc_2363 Proteasome subunit alpha type 6 52,65Pc_6554 Helix-loop-helix dna-binding domain-containing protein 52,61Pc_11913 --- n/a --- 52,61Pc_2158 Protein msf1 52,52Pc_3250 Nuclear polyadenylated rna-binding protein nab2 52,50Pc_1441 Phd-finger domain-containing protein 52,40Pc_1683 Rwd domain protein 52,36Pc_2038 Quercetin -dioxygenase 52,27Pc_11685 --- n/a --- 52,24Pc_502 U3 small nucleolar ribonucleoprotein mpp10 52,24Pc_4648 Integral membrane protein 52,17Pc_5843 Hypothetical protein maa_04296 52,13Pc_6542 Het domain 52,08Pc_10968 2-hydroxychromene-2-carboxylate isomerase 52,06Pc_862 Threonine 52,02Pc_9273 Calcineurin-like phosphoesterase 52,02Pc_5801 Hypothetical protein maa_05093 51,97Pc_1546 Serine hydroxymethyltransferase 51,79Pc_11785 --- n/a --- 51,77

Pc_3914 Mfs multidrug 51,77Pc_2950 Peptidase m61 domain-containing protein 51,75Pc_1867 Ribosomal large subunit 51,74Pc_10148 Amino acid transporter 51,72Pc_5667 Hypothetical protein maa_07418 51,71Pc_7888 Enth domain containing protein 51,65Pc_7090 Glutathione s- 51,63Pc_6076 Hypothetical protein maa_00223 51,62Pc_6353 Hlh transcription 51,61Pc_8082 Duf218 domain-containing protein 51,60Pc_379 Uncharacterized secreted protein 51,54Pc_2719 Phospholipid methyltransferase 51,49Pc_6698 Golgi transport complex subunit 51,49Pc_1160 Peroxisomal -dienoyl- reductase sps19 51,49Pc_1222 Sodium bile acid symporter family protein 51,48Pc_3560 N-acetyltransferase 5 51,42Pc_6771 Glycosyltransferase family 90 protein 51,41Pc_8118 Duf1275 domain protein 51,37Pc_7136 Glucosidase 2 subunit beta precursor 51,33Pc_4070 Metallopeptidase 51,32Pc_4216 Major facilitator superfamily transporter 51,15Pc_8151 Dopa -dioxygenase 51,15Pc_7853 Essential subunit of the histone deacetylase rpd3s complex 51,07Pc_1436 Sgt1 and cs domain containing protein 51,04Pc_6520 Het domain-containing protein 50,99Pc_9000 Centaurin beta 50,96Pc_1582 Secretory 50,93Pc_6782 Glycosyltransferase family 57 protein 50,89Pc_10547 Acetyltransferase-like protein 50,87Pc_3922 Mfs multidrug 50,87Pc_7492 Flavin containing amine 50,84Pc_7109 Glutamyl-trna amidotransferase 50,79Pc_520 Tyrosine phosphatase 50,78Pc_7640 Fad dependent oxidoreductase 50,74Pc_9815 Aspartyl-trna synthetase 50,71Pc_8189 Domain protein 50,68Pc_12116 --- n/a --- 50,55Pc_9652 Beta-lactamase domain protein 50,55Pc_9914 Arg-6 mitochondrial precursor 50,55Pc_2066 Pyridoxal-dependent decarboxylase 50,53Pc_4210 Major facilitator superfamily transporter 50,53Pc_11698 --- n/a --- 50,50Pc_363 Upf0047 domain protein 50,42Pc_6576 Heat shock protein 90 50,39Pc_4647 Integral membrane protein 50,29Pc_6034 Hypothetical protein maa_01193 50,27Pc_6028 Hypothetical protein maa_01340 50,25Pc_2018 Rad5-like protein 50,25Pc_4161 Map kinase 50,22Pc_1818 Ring finger domain-containing protein 50,19Pc_4144 Mdr efflux pump abc3 50,19

Pc_3504 Nad dependent epimerase 50,18Pc_6997 Glycoside hydrolase family 16 protein 50,13Pc_8350 Disulfide isomerase 50,12Pc_5724 Hypothetical protein maa_06289 50,08Pc_6599 Haloacid type ii 50,01Pc_265 Vacuolar protein sorting-associated protein 33a 49,92Pc_442 Ubiquitin-activating enzyme e1 1 49,86Pc_9700 Bag domain-containing protein 49,84Pc_6503 Heterogeneous nuclear ribonucleoprotein hrp1 49,77Pc_10164 Amino acid 49,73Pc_4530 Isocitrate dehydrogenase 49,69Pc_10762 6-phosphofructo-2-kinase 49,67Pc_10986 14-3-3-like protein 49,64Pc_4033 Methylcrotonoyl- carboxylase beta chain 49,62Pc_4589 Integral membrane protein 49,60Pc_11922 --- n/a --- 49,60Pc_1002 Pectin lyase 49,59Pc_1305 Signal recognition particle 54 kda protein 49,58Pc_9176 Carboxylic acid transport protein 49,54Pc_6471 Hexokinase family protein 49,52Pc_9464 C6 finger domain 49,50Pc_8388 Dihydrolipoamide acetyltransferase component 49,48Pc_219 Vitamin h 49,47Pc_3461 Nadh-ubiquinone oxidoreductase 23 kda subunit 49,39Pc_3696 Mitotic checkpoint protein bub3 49,39Pc_2711 Phosphomannose isomerase 49,34Pc_1698 Rta1 domain 49,32Pc_1444 Set domain-containing protein 49,25Pc_1795 Rna 2 -phosphotransferase 49,25Pc_5019 Hypothetical protein mac_09119 49,18Pc_6649 Gtp-binding protein ypt4 49,18Pc_8789 Conserved hypothetical protein 49,17Pc_8827 Conserved glutamic acid-rich protein 49,10Pc_5492 Hypothetical protein mac_00786 49,02Pc_3739 Mitochondrial inner membrane aaa protease 49,01Pc_4130 Mediator of rna polymerase ii transcription subunit 7 48,91Pc_7130 Glutamate carboxypeptidase 48,90Pc_5577 Hypothetical protein maa_09595 48,89Pc_3268 Nuclear cap binding protein subunit 2 48,82Pc_4388 Lactamase_b domain-containing protein 48,78Pc_1084 Succinate- ligase (alpha subunit) 48,75Pc_6920 Glycoside hydrolase family 5 protein 48,71Pc_8166 Domain-containing protein 48,67Pc_8724 Cullin family protein 48,66Pc_2536 Potassium transporter 48,61Pc_1792 Rna binding 48,57Pc_3038 Pal1 cell morphology protein 48,49Pc_6412 Histidine kinase hhk6p 48,48Pc_6789 Glycosyltransferase family 39 protein 48,46Pc_9190 Carboxylesterase family protein 48,43Pc_10568 Acetyl-coenzyme a transporter 1 48,43

Pc_7857 Erythromycin esterase, putative 48,41Pc_1308 Siderophore regulation protein 48,40Pc_9290 C6 zinc finger domain-containing protein 48,39Pc_8697 Cutinase transcription factor 1 beta 48,38Pc_559 Trna-dihydrouridine synthase 3 48,37Pc_4355 Leucine rich repeat domain-containing protein 48,35Pc_3734 Mitochondrial iron uptake protein 48,31Pc_5026 Hypothetical protein mac_09059 48,28Pc_9728 Atp25_nech7 ame: full=atpase synthesis protein mitochondrial flags: precur 48,25Pc_7336 Fungal specific transcription factor domain-containing protein 48,16Pc_6327 Homoisocitrate dehydrogenase 48,14Pc_5222 Hypothetical protein mac_05423 48,11Pc_7911 Endoribonuclease ysh1 48,07Pc_5639 Hypothetical protein maa_08227 48,05Pc_2055 Pyruvate decarboxylase 48,04Pc_10793 40s ribosomal protein s9 47,95Pc_1424 Short chain 47,92Pc_9501 C2h2 type zinc finger containing protein 47,91Pc_2616 Pol ii transcription elongation factor subunit 47,91Pc_9321 C6 zinc finger domain protein 47,89Pc_10058 Ankyrin repeat protein 47,79Pc_2613 Pol12 (dna-directed dna polymerase alpha) 47,77Pc_11406 Hypothetical protein bba_01847 47,70Pc_8973 Checkpoint serine threonine-protein kinase bub1 47,68Pc_10214 Amidase 47,60Pc_9049 Cell surface 47,58Pc_2708 Phosphopantothenoylcysteine decarboxylase 47,53Pc_4838 Hypothetical protein trividraft_152877 47,52Pc_1998 Ras like gtpase 47,50Pc_3894 Mfs quinate 47,48Pc_8477 Dash complex subunit duo1 47,42Pc_6370 Histone-fold domain containing protein 47,37Pc_8733 Ctl transporter, putative 47,34Pc_3459 Nadh-ubiquinone oxidoreductase 40 kda subunit 47,34Pc_2776 Phosphatidylinositol-specific phospholipase x domain containing protein 47,32Pc_9062 Cell division control protein 2 47,21Pc_2265 Protein 47,21Pc_6375 Histone h4 47,21Pc_5699 Hypothetical protein maa_06835 47,21Pc_10890 3-hydroxybutyryl- dehydrogenase 47,21Pc_2940 Peptide alpha-n-acetyltransferase 47,21Pc_8878 Clathrin heavy chain 47,05Pc_6077 Hypothetical protein maa_00210 46,97Pc_1774 Rna export mediator 46,96Pc_9568 Bys1 domain 46,91Pc_11852 --- n/a --- 46,81Pc_3647 Mrna export factor mex67 46,72Pc_3524 Nacht domain protein 46,64Pc_4454 Kinesin light chain 46,57Pc_4396 L-psp endoribonuclease family 46,56Pc_1152 Squalene epoxidase 46,56

Pc_2148 Protein phosphatase 2c 46,54Pc_1394 Short chain dehydrogenase reductase family 46,53Pc_8968 Chitin synthase 4 46,51Pc_1862 Ribosomal protein l23 46,50Pc_3912 Mfs multidrug resistance 46,45Pc_2873 Pex13 protein 46,30Pc_7250 Galactoside o-acetyltransferase 46,28Pc_4191 Malate synthase 46,18Pc_228 Vhs domain-containing protein 46,17Pc_12059 --- n/a --- 46,17Pc_3346 Nitrate assimilation regulatory protein nira 46,06Pc_8504 Cytosolic phospholipase a2 zeta 46,03Pc_10878 3-ketoacyl- reductase 45,99Pc_4162 Mannosylphosphorylation protein 45,98Pc_2132 Protein required for hyphal anastomosis (ham-2) 45,93Pc_2780 Phosphatidylinositol n-acetylglucosaminyltransferase subunit gpi1 45,91Pc_5056 Hypothetical protein mac_08381 45,87Pc_3661 Mosc domain containing protein 45,86Pc_3073 Oxygenase-like protein 45,85Pc_3128 Oligosaccharyl transferase stt3 subunit 45,77Pc_7291 G protein gamma subunit 45,71Pc_257 Vacuolar protein-sorting protein bro1 45,71Pc_4724 Importin subunit beta-1 45,71Pc_5143 Hypothetical protein mac_06750 45,69Pc_5669 Hypothetical protein maa_07410 45,64Pc_10079 Ankyrin and het domain-containing protein 45,58Pc_7603 Family decarboxylase 45,58Pc_3721 Mitochondrial precursor 45,52Pc_5783 Hypothetical protein maa_05357 45,51Pc_9294 C6 zinc finger domain-containing protein 45,51Pc_10650 Abc multidrug 45,43Pc_1400 Short chain dehydrogenase reductase family 45,41Pc_11506 --- n/a --- 45,39Pc_5787 Hypothetical protein maa_05307 45,39Pc_5897 Hypothetical protein maa_03556 45,34Pc_9555 Bzip transcription factor 45,31Pc_2599 Polyamine transport protein 45,29Pc_113 Xaa-pro dipeptidase 45,27Pc_8943 Choline transport 45,25Pc_2892 Peroxisomal hydratase-dehydrogenase-epimerase 45,19Pc_2831 Phd transcription factor 45,18Pc_3376 Neuronal calcium sensor 1 44,99Pc_6795 Glycosyltransferase family 32 protein 44,91Pc_3774 Cytochrome c oxidase-assembly factor mitochondrial 44,91Pc_646 Translocation protein sec72 44,91Pc_3043 Paf acetylhydrolase family protein 44,91Pc_5816 Hypothetical protein maa_04928 44,87Pc_6752 Glyoxalase family protein 44,83Pc_8378 Dihydroxy-acid dehydratase 44,79Pc_8591 Cytochrome p450 44,77Pc_576 Trna (uracil-5-)-methyltransferase 44,76

Pc_4693 Ino80-like protein 44,74Pc_10641 Abc multidrug transporter mdr1 44,72Pc_1306 Signal peptidase complex 44,64Pc_2364 Proteasome subunit alpha type 2 44,60Pc_1995 Ras small monomeric gtpase 44,60Pc_575 Trna (uracil-o -)-methyltransferase 44,55Pc_8026 Duf803 domain-containing protein 44,50Pc_11829 --- n/a --- 44,48Pc_22 Zinc-binding alcohol dehydrogenase domain-containing protein cipb 44,48Pc_9430 C6 transcription 44,48Pc_1260 Small oligopeptide opt family 44,44Pc_80 Zinc alcohol dehydrogenase 44,43Pc_1489 Serine threonine-protein kinase sck1 44,42Pc_8740 Crg1p s-adenosylmethionine-dependent methyltransferase 44,42Pc_8084 Duf21 and cbs domain protein 44,37Pc_12029 --- n/a --- 44,34Pc_3005 Patched sphingolipid transporter 44,22Pc_4111 Membrane associated 44,21Pc_10126 Aminopeptidase 2 44,18Pc_10615 Abc1 domain containing protein 44,17Pc_1501 Serine threonine-protein kinase endoribonuclease ire1 44,15Pc_4484 Kexin-like protease 44,10Pc_7392 Fungal alpha-l- 44,02Pc_749 Transcription factor cys6 43,98Pc_7477 Flavin-binding monooxygenase-like family protein 43,84Pc_5547 Hypothetical protein maa_10341 43,84Pc_10770 50s ribosomal protein mrp49 43,84Pc_5903 Hypothetical protein maa_03455 43,84Pc_3729 Mitochondrial nuclease 43,84Pc_4716 Indoleamine -dioxygenase subfamily 43,84Pc_6800 Glycosyltransferase family 31 protein 43,84Pc_7908 Endosomal p24b protein 43,84Pc_9099 Ccch zinc finger and smr domain containing protein 43,78Pc_8481 D-xylulose reductase a 43,72Pc_8967 Chitin synthase 6 43,72Pc_4553 Iq calmodulin-binding motif domain protein 43,71Pc_8353 Diphthamide biosynthesis protein 2 43,60Pc_1468 Serine threonine-protein phosphatase pp2a catalytic subunit 43,57Pc_9153 Carnitine acyl carnitine carrier 43,53Pc_6007 Hypothetical protein maa_01815 43,52Pc_12039 --- n/a --- 43,50Pc_230 Vesicular-fusion protein sec17 43,47Pc_9509 C2h2 transcription factor 43,47Pc_1977 Regulator of gluconeogenesis 43,44Pc_5580 Hypothetical protein maa_09521 43,42Pc_4032 Methylcrotonoyl- carboxylase subunit alpha 43,42Pc_5375 Hypothetical protein mac_02700 43,41Pc_2272 Protein 43,40Pc_7258 Gaba permease 43,37Pc_5387 Hypothetical protein mac_02554 43,28Pc_4223 Major facilitator superfamily transporter 43,24

Pc_10979 2-c-methyl-d-erythritol -cyclodiphosphate synthase 43,22Pc_6444 High-affinity nicotinic acid transporter 43,18Pc_5152 Hypothetical protein mac_06562 43,17Pc_8914 Chromo domain-containing protein 1 43,17Pc_1773 Rna interference and gene silencing protein 43,12Pc_6616 Gyf domain-containing protein 43,05Pc_8648 Cysteine protease atg4 43,02Pc_8071 Duf28 domain-containing protein 42,97Pc_5057 Hypothetical protein mac_08285 42,93Pc_3910 Mfs multidrug transporter 42,93Pc_6510 Het-domain-containing protein 42,91Pc_8287 Dna repair protein 42,91Pc_11488 --- n/a --- 42,82Pc_8354 Diphthamide biosynthesis protein 42,82Pc_9792 Atp synthase regulation protein nca2 42,80Pc_3079 Oxidoreductase family 42,76Pc_8165 Domain-containing protein 42,76Pc_9499 C2h2 type zinc finger containing protein 42,73Pc_7558 Fatty acid elongase 42,70Pc_4317 Lipoic acid synthetase 42,69Pc_3258 Nuclear envelope protein cut8 42,68Pc_6760 Glyoxalase bleomycin resistance protein dioxygenase 42,62Pc_2891 Peroxisomal hydratase-dehydrogenase-epimerase 42,51Pc_1130 Stf2-like protein 42,49Pc_9670 Beta- -glucan synthase catalytic subunit 42,40Pc_2213 Protein kinase 7 42,40Pc_6541 Het domain containing protein 42,39Pc_925 Tetraspanin tsp3 42,38Pc_4593 Related to integral membrane protein pth11 42,24Pc_9149 Cas1 appressorium specific protein 42,15Pc_8056 Duf498 domain protein 42,15Pc_7940 Elongation factor g 1 42,12Pc_3917 Mfs multidrug 42,06Pc_8867 Cmkk2 protein 42,05Pc_9083 Cell cycle control protein 42,00Pc_11000 -type g-protein coupled receptor protein 42,00Pc_5041 Hypothetical protein mac_08780 42,00Pc_7917 Endoplasmic oxidoreductin-1 41,87Pc_3569 Myosin type ii heavy chain 41,86Pc_8851 Coenzyme q biosynthesis protein coq4 41,85Pc_6785 Glycosyltransferase family 4 protein 41,80Pc_10102 Anaphase-promoting complex component cut20 apc4 41,76Pc_6606 Had-superfamily hydrolase 41,74Pc_8964 Chitin synthase d 41,70Pc_1866 Ribosomal protein 35 41,66Pc_5321 Hypothetical protein mac_03689 41,61Pc_1718 Rrm domain-containing protein 41,61Pc_3427 Nadp-specific glutamate dehydrogenase 41,49Pc_5791 Hypothetical protein maa_05220 41,47Pc_8086 Duf1909-domain-containing protein 41,47Pc_6163 Hypothetical protein fg08289.1 41,47

Pc_9137 Casein kinase ii subunit alpha 41,45Pc_7128 Glutamate decarboxylase 41,40Pc_11101 Thioredoxin reductase 41,38Pc_2643 Pinus taeda anonymous locus 0_18914_01 genomic sequence 41,34Pc_7445 Fmn binding 41,34Pc_9124 Catechol 41,29Pc_8266 Dna replication complex gins protein psf2 41,24Pc_5933 Hypothetical protein maa_02932 41,21Pc_278 Vacuolar protein sorting-associated protein 26 41,17Pc_334 Urea transporter 41,15Pc_6661 Gtp-binding protein 41,12Pc_8668 Cyclophilin-type peptidyl-prolyl cis-trans isomerase 41,12Pc_605 Triacylglycerol lipase 41,06Pc_6933 Glycoside hydrolase family 37 protein 41,04Pc_1544 Serine palmitoyltransferase 1 41,01Pc_10149 Amino acid permease family 41,00Pc_9227 Capsular associated protein 40,92Pc_4080 Metallo-beta-lactamase domain 40,92Pc_12100 --- n/a --- 40,92Pc_4734 Immunoglobulin variable region used by the itc63b heavy chain 40,92Pc_7714 F-box domain-containing protein 40,92Pc_9084 Cell cycle checkpoint protein rad17 40,89Pc_10025 Ankyrin repeat protein 40,84Pc_822 Cytochrome p450 40,75Pc_7980 Ebs-bah-phd domain-containing protein 40,75Pc_7403 Fumarylacetoacetate hydrolase 40,74Pc_10703 60s ribosomal protein mitochondrial precursor 40,66Pc_1631 Sarcosine oxidase 40,63Pc_9759 Atp-dependent rna helicase 40,58Pc_2034 Quinate permease 40,54Pc_10713 60s ribosomal protein l36 40,53Pc_10859 3-oxoacyl-(acyl-carrier-protein) reductase 40,51Pc_9541 C-5 sterol desaturase 40,45Pc_6586 Heat repeat protein 40,42Pc_10413 Agmatinase 1 40,40Pc_7644 Fad dependent 40,40Pc_239 Vegetative incompatibility protein het-e-1 40,39Pc_8646 Cysteine synthase 40,38Pc_7027 Glycine dehydrogenase 40,33Pc_4674 Insecticidal toxin complex protein 40,30Pc_9391 C6 transcription 40,29Pc_4989 Hypothetical protein mgg_05482 40,28Pc_1805 Ring-7 protein 40,28Pc_5874 Hypothetical protein maa_04010 40,25Pc_1269 Small nuclear ribonucleoprotein sm d1 40,25Pc_2005 Ran-specific gtpase-activating protein 40,25Pc_11405 Hypothetical protein bba_02892 40,25Pc_8535 Cytochrome p450 family 40,23Pc_632 Transmembrane protein 40,20Pc_8574 Cytochrome p450 40,18Pc_10709 60s ribosomal protein l44 40,15

Pc_5837 Hypothetical protein maa_04487 40,15Pc_6183 Hypothetical protein chgg_05194 40,11Pc_3882 Mfs toxin efflux pump 40,11Pc_4457 Kinesin heavy chain 40,06Pc_6022 Hypothetical protein maa_01423 40,06Pc_9233 Candidapepsin-4 precursor 40,06Pc_8514 Cytoplasm to vacuole targeting vps64 39,99Pc_8513 Cytoplasmic dynein 1 intermediate chain 2 39,97Pc_9066 Cell division control protein 10 39,95Pc_11202 Hypothetical protein tsta_066400 39,92Pc_1304 Signal recognition particle 68 kda protein 39,92Pc_444 Ubiquitin supergroup 39,90Pc_5 Zn cluster transcription factor 39,84Pc_9845 Ascus development protein 39,77Pc_10565 Acetylornithine aminotransferase 39,75Pc_7406 Fumarate reductase flavoprotein subunit 39,75Pc_8452 Defensin domain protein 39,72Pc_1590 Secreted protein 39,70Pc_6386 Histone deacetylase interacting 39,70Pc_2515 Pre-mrna splicing factor 39,69Pc_9020 Cell wall protein 39,68Pc_9569 Budding protein boi2 39,66Pc_1793 Rna binding 39,60Pc_5209 Hypothetical protein mac_05633 39,60Pc_5285 Hypothetical protein mac_04318 39,57Pc_294 Vacuolar atp synthase subunit h 39,56Pc_2514 Pre-mrna splicing factor 39,54Pc_7828 Eukaryotic translation initiation factor 2c 39,48Pc_750 C2h2 transcription factor 39,48Pc_1134 Sterol desaturase family 39,45Pc_6939 Glycoside hydrolase family 30 protein 39,39Pc_94 Impb mucb samb family protein 39,37Pc_3127 Oligosaccharyltransferase alpha subunit 39,31Pc_6705 Golgi mannosyltransferase complex subunit 39,31Pc_7049 Glycan biosynthesis protein 39,28Pc_1904 Rhomboid family membrane protein 39,18Pc_10338 Aldo-keto reductase 39,18Pc_2497 Pre-mrna-splicing factor 39,15Pc_8923 Chromatin assembly subunit p90 39,13Pc_3035 Palmitoyltransferase akr1 39,09Pc_5832 Hypothetical protein maa_04643 39,08Pc_9077 Cell cycle control protein cwf16 39,06Pc_12079 --- n/a --- 39,03Pc_1208 Solute carrier family 35 member c2 39,01Pc_3683 Modin 38,97Pc_8437 Denn domain-containing protein 38,92Pc_2212 Protein kinase activator 38,91Pc_9381 C6 transcription 38,87Pc_1520 Serine threonine protein kinase 38,83Pc_3103 Orp1 like protein 38,81Pc_9193 Carboxylesterase 38,80

Pc_6070 Hypothetical protein maa_00314 38,79Pc_6634 Gtr1 g domain containing protein 38,78Pc_10943 26s proteasome non-atpase regulatory subunit 11 38,70Pc_2105 Peptidase tripeptidyl-peptidase 38,68Pc_9440 C6 transcription 38,67Pc_11027 -diketo-5-methylthio-1-phosphopentane phosphatase 38,66Pc_1439 Sexual development activator 38,65Pc_10832 4-coumarate- ligase 2 38,43Pc_3826 Microtubule binding protein 38,41Pc_11287 Hypothetical protein mac_03420 38,36Pc_601 Triacylglycerol lipase 38,36Pc_4809 Hypothetical protein trividraft_226129 38,36Pc_6784 Glycosyltransferase family 41 protein 38,36Pc_2384 Prostacyclin synthase 38,29Pc_10570 Acetyl- synthetase-like protein 38,23Pc_10954 2-oxoisovalerate dehydrogenase subunit beta 38,17Pc_431 Ubiquitin-conjugating enzyme e2-20 kda 38,15Pc_10724 60s ribosomal protein l24 38,12Pc_5908 Hypothetical protein maa_03412 38,12Pc_8506 Cytosolic fe-s cluster assembling factor cfd1 38,11Pc_10732 60s ribosomal protein l19 38,06Pc_3511 Nad dependent epimerase 38,04Pc_6884 Glycoside hydrolase family 76 protein 38,03Pc_8775 Cop9 signalosome complex subunit 4 38,00Pc_9471 C6 finger domain 37,97Pc_1954 Related to rna-binding protein cabeza 37,95Pc_9271 Calcineurin-like phosphoesterase 37,92Pc_6778 Glycosyltransferase family 62 protein 37,89Pc_4305 Low molecular weight phosphotyrosine protein phosphatase 37,89Pc_9968 Ankyrin repeat-containing protein 37,87Pc_831 Protein tos1 37,87Pc_1296 Signal transduction protein 37,86Pc_10692 Hypothetical protein triatdraft_298933 37,82Pc_6689 Gpi ethanolamine phosphate transferase 37,80Pc_11652 --- n/a --- 37,77Pc_3271 Ntpase 37,77Pc_7988 E3 ubiquitin-protein ligase 37,76Pc_1517 Serine threonine protein kinase 37,71Pc_2764 Phosphoenolpyruvate carboxykinase 37,69Pc_10442 Adenylosuccinate synthetase 37,68Pc_12018 --- n/a --- 37,64Pc_3269 Nuclear and cytoplasmic polyadenylated rna-binding protein pub1 37,61Pc_4086 Metal homeostatis protein bsd2 37,58Pc_7467 Flavin-containing monooxygenase 37,58Pc_11431 Fungal specific transcription 37,58Pc_5329 Hypothetical protein mac_03571 37,54Pc_9459 C6 finger domain protein 37,51Pc_7356 Fungal specific transcription factor 37,50Pc_5388 Hypothetical protein mac_02548 37,48Pc_5535 Hypothetical protein mac_00149 37,45Pc_10592 Acetoacetate- ligase 37,42

Pc_73 Ring finger domain-containing protein 37,38Pc_5427 Hypothetical protein mac_01818 37,33Pc_7805 Eukaryotic translation initiation factor 6 37,27Pc_2852 Ph domain-containing protein 37,26Pc_7535 Fermentation respiration switch protein 37,24Pc_4386 Lactose permease 37,23Pc_9742 Atp-dependent rna helicase has1 37,20Pc_8715 Cupin domain protein 37,20Pc_6047 Hypothetical protein maa_00850 37,20Pc_8743 Cral trio domain-containing protein 37,20Pc_4243 Major facilitator superfamily transporter 37,17Pc_4832 Hypothetical protein trividraft_193759 37,13Pc_9339 C6 zinc finger domain containing protein 37,12Pc_10425 Aerobactin siderophore biosynthesis protein iucb 37,12Pc_7848 Esterase family protein 37,11Pc_8839 Complex i intermediate-associated protein 84 37,11Pc_4701 Inner membrane magnesium transporter mrs2 37,09Pc_5370 Hypothetical protein mac_02767 37,07Pc_8781 Conserved oligomeric golgi complex subunit 2 37,07Pc_4295 Lte1 protein 37,07Pc_4974 Hypothetical protein mycth_2309692 37,05Pc_6658 Gtp-binding protein 37,00Pc_2785 Phosphatidylinositol -bisphosphate-binding 37,00Pc_5275 Hypothetical protein mac_04423 36,95Pc_6601 Haloacid dehalogenase-like hydrolase 36,87Pc_1687 Rta1 like protein 36,86Pc_7548 Fatty acid synthase beta subunit dehydratase 36,86Pc_6653 Gtp-binding protein rho3 36,83Pc_5091 Hypothetical protein mac_07518 36,76Pc_6568 Heat-labile a chain 36,75Pc_8360 Dipeptidyl aminopeptidase acylaminoacyl peptidase 36,74Pc_8969 Chitin synthase 1 36,73Pc_9029 Cell wall glycosyl hydrolase 36,72Pc_10113 Amp deaminase 36,69Pc_2520 Pre-mrna cleavage complex ii protein clp1 36,66Pc_7695 Fad-dependent oxidoreductase 36,66Pc_122 Ww domain binding protein 11 36,64Pc_2427 Prefoldin subunit 1 36,64Pc_7930 Endo- -beta- 36,61Pc_4511 Isopenicillin n synthase and related dioxygenase 36,59Pc_4771 Hypothetical protein vdag_02410 36,58Pc_2280 Protein 36,57Pc_6283 Hydrophobin 36,55Pc_8343 Dna damage checkpoint protein rad24 36,51Pc_5369 Hypothetical protein mac_02838 36,51Pc_4568 Intermembrane space aaa protease iap-1 36,48Pc_8611 Cytochrome c oxidase polypeptide vib 36,46Pc_1912 Rho-gtpase-activating protein 8 36,45Pc_11639 --- n/a --- 36,41Pc_8701 Cutinase transcription factor 1 alpha 36,40Pc_8703 Cutinase negative acting protein 36,40

Pc_1166 Spo76 protein 36,28Pc_323 Uridine kinase 36,27Pc_9808 Atp binding 36,23Pc_3157 Oestrogen-responsive protein fam102a b 36,21Pc_7296 Fyve domain 36,11Pc_4706 Infection structure specific protein 36,11Pc_1472 Serine threonine-protein phosphatase 5 36,11Pc_6690 Gpi anchored serine-threonine rich protein 36,11Pc_11324 Hypothetical protein maa_07234 36,11Pc_5199 Hypothetical protein mac_05809 36,07Pc_7323 Fungal transcriptional regulatory protein 36,05Pc_10607 Abscisic acid aba receptor 36,02Pc_997 Swi snf family dna-dependent atpase 35,96Pc_11081 Zn2 cys6 dna-binding protein 35,94Pc_3772 Mitochondrial deoxynucleotide carrier 35,91Pc_6921 Glycoside hydrolase family 5 protein 35,87Pc_2260 Protein 35,87Pc_9044 Cell surface protein 35,87Pc_1022 Sulfite oxidase 35,78Pc_3048 Pa domain-containing protein 35,74Pc_1462 Serine-type carboxypeptidase 35,72Pc_3129 Oligosaccharyl transferase 35,64Pc_7968 Efflux pump antibiotic resistance 35,63Pc_8762 Copper fist dna binding domain protein 35,63Pc_10166 Amino acid 35,62Pc_2783 Phosphatidylinositol 3-kinase tor2 35,57Pc_1521 Serine threonine protein kinase 35,57Pc_4820 Hypothetical protein trividraft_216181 35,51Pc_5354 Hypothetical protein mac_03116 35,51Pc_11589 --- n/a --- 35,51Pc_7405 Fumarate reductase succinate dehydrogenase flavoprotein 35,47Pc_4270 Mads box protein 35,46Pc_8333 Dna excision repair protein ercc-8 35,44Pc_2440 Predicted protein 35,41Pc_7722 F-box domain-containing protein 35,39Pc_849 Extracelular serine carboxypeptidase 35,39Pc_4730 Importin 13 35,35Pc_5284 Hypothetical protein mac_04328 35,34Pc_10742 60s ribosomal protein l11 35,28Pc_10651 Abc multidrug 35,22Pc_10219 Alternative oxidase 35,13Pc_5475 Hypothetical protein mac_01068 35,07Pc_9281 Ca2+-modulated nonselective cation channel polycystin 35,01Pc_5743 Hypothetical protein maa_06019 35,00Pc_848 Hect-domain-containing protein 34,99Pc_2953 Peptidase m16 inactive domain-containing protein 34,97Pc_4754 Hypothetical protein 34,92Pc_6783 Glycosyltransferase family 48 protein 34,89Pc_7869 Er membrane protein 34,87Pc_6693 Gpi anchored 34,84Pc_8461 Dead deah box helicase 34,84

Pc_6580 Heat shock protein 30 34,80Pc_6411 Histidine kinase m232p 34,80Pc_10376 Alcohol dehydrogenase i 34,78Pc_516 Tyrosine-protein phosphatase pmp1 34,77Pc_28 Zinc-binding dehydrogenase family 34,74Pc_3179 Nulp1-pending protein 34,73Pc_7616 Fad-binding domain protein 34,69Pc_1798 Rint-1 family protein 34,68Pc_4316 Lmbr1 domain-containing protein 34,64Pc_4025 Methylmalonate-semialdehyde dehydrogenase 34,62Pc_11232 Hypothetical protein nechadraft_53329 34,62Pc_5367 Hypothetical protein mac_02923 34,61Pc_6950 Glycoside hydrolase family 3 protein 34,61Pc_1848 Ribosomal rna-processing protein 8 34,58Pc_10872 3-ketoacyl-acyl carrier protein reductase 34,56Pc_6665 Gtp cyclohydrolase 34,53Pc_6051 Hypothetical protein maa_00802 34,50Pc_1042 Sulfatase domain protein 34,48Pc_2500 Pre-mrna-processing factor 17 34,48Pc_8046 Duf636 domain protein 34,48Pc_9293 C6 zinc finger domain-containing protein 34,47Pc_8124 Duf124 domain-containing protein 34,39Pc_8182 Domain-containing protein 34,38Pc_5884 Hypothetical protein maa_03859 34,37Pc_4039 Methionyl-trna synthetase 34,21Pc_3029 Pantoate-beta-alanine ligase 34,19Pc_316 Uv radiation resistance protein 34,16Pc_7584 Family protein 34,10Pc_4807 Hypothetical protein trividraft_231671 34,10Pc_11029 -dihydroxy-2-butanone 4-phosphate synthase 34,10Pc_4337 Lipase 34,10Pc_11968 --- n/a --- 34,10Pc_7957 Elastinolytic metalloproteinase mep 34,10Pc_7831 Eukaryotic translation initiation factor 2 alpha subunit 34,10Pc_6399 Histone acetyltransferase esa1 34,01Pc_10544 Acid 34,00Pc_2830 Phd transcription factor 33,97Pc_10279 Alpha beta hydrolase fold family protein 33,97Pc_9257 Calcium permease 33,95Pc_4306 Low affinity copper transporter 33,93Pc_10792 5 -3 exoribonuclease 33,91Pc_9005 Cellular morphogenesis regulator 33,90Pc_8490 D-lactate dehydrogenase 33,89Pc_2150 Protein phosphatase 2c 33,86Pc_1294 Sir2 family protein 33,84Pc_10580 Acetyl esterase 33,80Pc_7333 Fungal specific transcription factor domain-containing protein 33,80Pc_8419 Di- -cis-decaprenylcistransferase 33,79Pc_2951 Peptidase m4 thermolysin 33,77Pc_1700 Rta1 domain 33,76Pc_8248 Dna-binding protein 33,75

Pc_5607 Hypothetical protein maa_08956 33,72Pc_8761 Copper homeostasis protein cutc 33,72Pc_5536 Hypothetical protein mac_00130 33,68Pc_7932 Endo alpha- polygalactosaminidase precusor 33,68Pc_1298 Signal sequence receptor alpha subunit 33,67Pc_910 Thermoresistant gluconokinase 33,63Pc_1907 Rhodanese-like protein 33,63Pc_9898 Arginine permease 33,63Pc_4650 Integral membrane protein 33,61Pc_5350 Hypothetical protein mac_03183 33,59Pc_9764 Atp-dependent protease la 33,58Pc_1157 Spry domain-containing protein 33,53Pc_3208 Nucleoside deaminase 33,53Pc_4204 Major facilitator superfamily transporter 33,48Pc_6637 Gtpase-activating protein gyp5 33,47Pc_7294 G protein alpha subunit 33,44Pc_8549 Cytochrome p450 61 33,44Pc_9838 Aspartate aminotransferase 33,43Pc_303 Vacuolar atp synthase 20 kda proteolipid subunit 33,42Pc_11874 --- n/a --- 33,40Pc_3889 Mfs sugar 33,39Pc_6793 Glycosyltransferase family 34 protein 33,34Pc_3751 Mitochondrial import inner membrane translocase subunit tim-50 33,33Pc_2737 Phospholipase a-2-activating protein 33,31Pc_3282 Nonsense-mediated mrna decay protein 3 33,31Pc_2496 Pre-mrna-splicing factor 38b 33,31Pc_325 D-glycerate 3-kinase 33,29Pc_2149 Protein phosphatase 2c 33,23Pc_1303 Signal recognition particle protein 33,20Pc_6623 Guanosine-diphosphatase 33,18Pc_2028 R3h domain 33,18Pc_5100 Hypothetical protein mac_07345 33,18Pc_10666 Aaa family atpase 33,13Pc_5822 Hypothetical protein maa_04853 33,10Pc_10073 Ankyrin partial 33,10Pc_9200 Carbonic anhydrase 33,10Pc_10795 40s ribosomal protein s7 33,10Pc_1761 Rna polymerase ii subunit a c-terminal domain phosphatase 33,07Pc_6205 Hypothetical protein ccm_07314 33,07Pc_8895 Citrinin biosynthesis oxydoreductase 33,05Pc_4395 L-psp endoribonuclease family protein 33,05Pc_10633 Abc transporter 33,03Pc_5227 Hypothetical protein mac_05272 32,98Pc_6565 Heavy metal tolerance protein precursor 32,96Pc_7056 Glutathione-dependent formaldehyde-activating enzyme 32,96Pc_8491 D-lactate dehydrogenase 32,95Pc_7 Zn 2cys6 transcription factor 32,95Pc_5141 Hypothetical protein mac_06755 32,92Pc_6703 Golgi membrane 32,92Pc_3940 Mfs monocarboxylic acid transporter 32,90Pc_6454 High affinity camp 32,88

Pc_4288 Lysophospholipase precursor 32,70Pc_8859 Coatomer beta subunit 32,67Pc_5167 Hypothetical protein mac_06330 32,63Pc_3434 Nadp-dependent alcohol dehydrogenase 32,63Pc_2550 Positive regulator of purine utilization 32,61Pc_10753 6-phosphogluconate dehydrogenase nad-binding protein 32,59Pc_9923 Apoptosis-inducing taf9-like domain 1 family 32,59Pc_5597 Hypothetical protein maa_09191 32,58Pc_2814 Phenylalanyl-trna synthetase 32,57Pc_8951 Choline dehydrogenase 32,56Pc_1013 Superoxide dismutase 32,53Pc_2922 Peptidyl-prolyl cis-trans isomerase pin4 32,52Pc_1809 Ring-15 protein 32,50Pc_154 Wd repeat-containing protein jip5 32,49Pc_7716 F-box domain-containing protein 32,45Pc_9505 C2h2 transcription factor 32,41Pc_3698 Mitosis protein dim1 32,30Pc_8139 Dsdna-binding protein 32,30Pc_8433 Deoxyribose-phosphate aldolase 32,30Pc_3498 Nad dependent epimerase dehydratase family protein 32,30Pc_11339 Hypothetical protein maa_04964 32,30Pc_9587 Brefeldin a resistance protein 32,24Pc_8639 Cysteinyl-trna synthetase 32,22Pc_3558 N-acylsphingosine amidohydrolase 32,22Pc_4262 Major allergen asp f 2-like protein 32,20Pc_10698 75k gamma secalin 32,16Pc_3677 Molybdopterin binding domain protein 32,15Pc_5201 Hypothetical protein mac_05759 32,13Pc_9878 Arp2 3 actin-organizing complex subunit sop2 32,13Pc_3289 Nonselective cation channel 32,11Pc_6592 Hd family 32,06Pc_9169 Carboxypeptidase s1 32,06Pc_9734 Atp-dependent rrna helicase rrp3 32,04Pc_7141 Glucose-methanol-choline oxidoreductase 32,03Pc_92 Ydr124wp-like protein 32,01Pc_9691 Beige beach domain protein 31,99Pc_11338 Hypothetical protein maa_05040 31,99Pc_3210 Nucleoporin pom152 31,97Pc_2210 Protein kinase activator bem1 31,97Pc_908 Thiamin biosynthesis protein (thi-4) 31,97Pc_7796 Exocyst complex component exo84 31,96Pc_9940 Antigenic cell wall 31,93Pc_5657 Hypothetical protein maa_07682 31,89Pc_9884 Armadillo-type fold domain containing protein 31,85Pc_6529 Het domain protein 31,79Pc_10470 Acyl-coenzyme a:6-aminopenicillanic-acid-acyltransferase 40 kda 31,78Pc_676 Transglutaminase-like superfamily protein 31,76Pc_8345 Dna binding regulatory protein 31,75Pc_1098 Subtilisin-like protease pr1i 31,75Pc_569 Trna ligase 31,73Pc_10432 Adp-ribosylation factor family protein 31,70

Pc_8645 Cysteine synthase 31,70Pc_4059 Metalloprotease 31,66Pc_10179 Amine flavin-containing superfamily 31,66Pc_11469 Ankyrin repeat protein 31,64Pc_5111 Dephospho- kinase 31,62Pc_3648 Mrna decapping 31,62Pc_9098 Ccch zinc finger dna binding protein 31,60Pc_172 Wd repeat protein 31,60Pc_290 Vacuolar calcium ion transporter 31,59Pc_7520 Ferulic acid esterase 31,52Pc_2422 Prenylcysteine oxidase 31,50Pc_10076 Ankyrin partial 31,48Pc_7542 Fatty-acid amide hydrolase 31,48Pc_591 Transferase hexapeptide domain protein 31,48Pc_941 Telomerase activating protein est1 31,48Pc_3822 Mind kinetochore complex component 31,43Pc_12004 --- n/a --- 31,42Pc_9207 Carbohydrate-binding protein 31,39Pc_4139 Mediator of rna polymerase ii transcription subunit 12 31,36Pc_10723 60s ribosomal protein l26 31,36Pc_864 Threonine aldolase 31,32Pc_8676 Cyclin-like f-box 31,32Pc_5431 Hypothetical protein mac_01752 31,30Pc_438 Ubiquitin-conjugating enzyme 31,30Pc_5444 Hypothetical protein mac_01596 31,29Pc_7929 Endo- -beta-glucanase 31,28Pc_5985 Hypothetical protein maa_02175 31,25Pc_6427 Histidine kinase 31,21Pc_3642 Mrna-capping enzyme subunit beta 31,21Pc_1313 Siderophore iron transporter mirb 31,21Pc_11237 Hypothetical protein mycth_2056329 31,21Pc_1956 Related to ribosomal protein 11 mitochondrial 31,18Pc_737 Transcription factor sptfiie alpha subunit 31,17Pc_8014 Duf895 domain membrane protein 31,17Pc_6398 Histone acetyltransferase gcn5 31,13Pc_8616 Cytochrome c oxidase biogenesis protein cmc1-like protein 31,08Pc_8093 Duf1760-domain-containing protein 31,06Pc_3082 Oxidoreductase domain protein 31,03Pc_9547 Bzip-type transcription factor 31,02Pc_5703 Hypothetical protein maa_06775 31,02Pc_274 Vacuolar protein-sorting-associated protein 36 31,02Pc_1488 Serine threonine-protein kinase sgk2 31,01Pc_10229 Alpha-l-fucosidase 31,00Pc_3109 Ornithine aminotransferase 30,97Pc_1299 Signal sequence receptor alpha subunit 30,92Pc_1613 Sec20 domain protein 30,92Pc_846 Tim-barrel enzyme family protein 30,91Pc_6688 Gpi ethanolamine phosphate transferase 1 30,91Pc_9340 C6 zinc finger domain containing protein 30,90Pc_7233 Gata transcription factor 30,89Pc_3843 Mfs transporter 30,86

Pc_11334 Hypothetical protein maa_05958 30,84Pc_4349 Leukotriene a-4 hydrolase 30,84Pc_4591 Integral membrane protein 30,83Pc_10642 Abc multidrug transporter 30,82Pc_3865 Mfs transporter 30,81Pc_6518 Het domain-containing protein 30,80Pc_703 Transcriptional activator spt7 30,80Pc_2899 Peroxisomal biogenesis factor 6 30,79Pc_10261 Alpha- - 30,77Pc_7377 Fungal specific transcription 30,73Pc_3775 Mitochondrial cytochrome c oxidase assembly factor 30,69Pc_11394 Hypothetical protein ch063_05373 30,69Pc_2798 Phosphate-repressible na+ phosphate cotransporter 30,69Pc_10741 60s ribosomal protein l12 30,69Pc_5683 Hypothetical protein maa_07125 30,62Pc_33 Zinc-type alcohol dehydrogenase-like protein 30,60Pc_3062 P-type atpase 30,54Pc_3405 Nb-arc and ankyrin domain protein 30,54Pc_4517 Isoleucyl-trna synthetase 30,54Pc_2356 Protein 30,51Pc_9117 Cation diffusion facilitator 1 30,50Pc_7601 Family metal ion transporter 30,46Pc_664 Translation initiation factor eif-2b subunit alpha 30,42Pc_8255 Dna replication licensing factor mcm6 30,41Pc_102 D-xylulose reductase a 30,31Pc_987 Swr1-complex protein 5 30,31Pc_3358 Nicotinamide mononucleotide adenylyl transferase 30,26Pc_993 Swib mdm2 domain protein 30,26Pc_11214 Hypothetical protein trividraft_198205 30,24Pc_179 Protein-vacuolar targeting protein atg18 30,24Pc_8047 Duf618 domain-containing protein 30,19Pc_11436 Exported protein 30,19Pc_5512 Ser thr protein phosphatase family protein 30,15Pc_1378 Short-chain dehydrogenase reductase family 30,13Pc_3278 Npiia_colgm ame: full=neutral protease 2 homolog mgg_10927 ame: full=d 30,11Pc_8268 Dna replication checkpoint mediator 30,11Pc_10501 Activator 1 41 kda subunit 30,10Pc_9806 Atp citrate lyase subunit 2 30,06Pc_6003 Hypothetical protein maa_01914 30,02Pc_1230 Snf2 family helicase 30,02Pc_2870 Pfs domain containing protein 30,00Pc_2934 Peptidoglycan binding domain containing protein 29,97Pc_60 Zinc finger protein 29,94Pc_3412 Nadph-dependent fmn reductase 29,94Pc_3847 Mfs transporter 29,91Pc_3423 Nadph dehydrogenase 29,90Pc_818 Nucleoside-diphosphate-sugar 29,89Pc_6506 Het-s domain-containing protein 29,87Pc_2603 Polya nuclease 29,85Pc_6889 Glycoside hydrolase family 76 protein 29,83Pc_4912 Hypothetical protein ptt_15811 29,83

Pc_4278 M protein repeat protein 29,81Pc_972 Transcription initiation factor subunit taf1 29,73Pc_6899 Glycoside hydrolase family 75 protein 29,73Pc_1088 Succinate dehydrogenase flavoprotein subunit 29,72Pc_10944 26s protease regulatory subunit 8 29,66Pc_5413 Hypothetical protein mac_02089 29,65Pc_1021 Sulfite reductase 29,65Pc_7819 Eukaryotic translation initiation factor 3 subunit 3 29,64Pc_1802 Ring-9 protein 29,63Pc_4510 Isopenicillin n synthetase 29,58Pc_8230 Dna-directed rna polymerase iii subunit 29,55Pc_562 Trna splicing endonuclease subunit 29,55Pc_6169 Hypothetical protein fg04435.1 29,52Pc_6727 Gnat family 29,48Pc_7842 Ethanolamine-phosphate cytidylyltransferase 29,48Pc_598 Tricarboxylate carrier 29,48Pc_1894 Riboflavin transporter mch5 29,47Pc_9621 Bifunctional p-450:nadph-p450 reductase 29,47Pc_3070 Oxysterol binding protein 29,44Pc_9004 Cellular nucleic acid-binding protein 29,40Pc_4443 Kinesin related protein 2 29,38Pc_8111 Duf1479 domain-containing protein 29,37Pc_4752 Hypothetical protein 29,37Pc_9594 Branchpoint-bridging protein 29,37Pc_3640 Msf superfamily transporter 29,34Pc_2965 Peptidase family m1 29,33Pc_7251 Galactose-1-phosphate uridylyltransferase 29,32Pc_4795 Hypothetical protein trividraft_54988 29,29Pc_6285 Hydrolase 29,23Pc_1523 Serine threonine protein kinase 29,15Pc_3725 Mitochondrial phosphate carrier protein 29,14Pc_3071 Oxysterol binding protein 29,13Pc_9746 Atp-dependent rna helicase dob1 29,12Pc_10197 Amidohydrolase 29,11Pc_3259 Nuclear envelope protein 29,10Pc_3003 Pathway-specific nitrogen regulator 29,08Pc_11233 Hypothetical protein nechadraft_42400 29,07Pc_939 Telomere length regulation protein 29,03Pc_3746 Mitochondrial import protein 29,00Pc_5113 Hypothetical protein mac_07186 29,00Pc_2601 Polyadenylate-binding protein 28,95Pc_10098 Anaphase-promoting complex subunit cut9 28,94Pc_9827 Aspartate-semialdehyde dehydrogenase 28,92Pc_5368 Hypothetical protein mac_02911 28,86Pc_1635 Sap domain-containing protein 28,85Pc_10038 Ankyrin repeat protein 28,77Pc_10895 3-hydroxyacyl- dehydrogenase 28,77Pc_7409 Fumarate reductase 28,77Pc_526 Tyrosinase 2 28,75Pc_6194 Hypothetical protein ch063_02843 28,75Pc_4620 Integral membrane protein 28,75

Pc_7706 F-box wd repeat-containing protein 1a 28,73Pc_5159 Hypothetical protein mac_06380 28,72Pc_7898 Enoyl- hydratase 28,70Pc_2393 Prolipoprotein diacylglyceryl transferase 28,70Pc_1701 Rsc complex subunit rsc9 28,70Pc_11290 Hypothetical protein mac_03004 28,70Pc_10269 Alpha beta hydrolase fold-3 domain-containing protein 28,63Pc_8467 Ddt domain-containing protein 28,63Pc_6227 Hypothetical protein ccm_00525 28,61Pc_803 Tpa_inf: gpr1 fun34 -class plasma membrane protein 28,60Pc_1903 Rhomboid family protein 28,58Pc_2648 Phytanoyl- dioxygenase family protein 28,55Pc_11352 Hypothetical protein maa_03178 28,55Pc_7609 Fam86a protein 28,55Pc_2882 Peroxisomal pex24-like protein 28,49Pc_4301 Low-temperature viability protein ltv1 28,44Pc_529 Response regulator mcs4 28,39Pc_8675 Cyclin-like f-box 28,38Pc_11772 --- n/a --- 28,38Pc_3797 Mitochondrial carrier 28,36Pc_8983 Cfem domain-containing protein 28,36Pc_8572 Cytochrome p450 28,35Pc_7302 Fungal zn binuclear cluster domain containing protein 28,30Pc_1128 Stomatin-like protein 28,30Pc_7054 Glutathione-dependent formaldehyde-activating enzyme 28,27Pc_8130 Duf1212 domain membrane protein 28,25Pc_773 Transcription factor 28,25Pc_2327 Protein 28,21Pc_5619 Hypothetical protein maa_08738 28,17Pc_4995 Hypothetical protein mac_09756 28,16Pc_3046 Pab-dependent poly -specific ribonuclease subunit pan3 28,11Pc_3224 Nucleolar complex protein 28,10Pc_4880 Hypothetical protein triatdraft_141566 28,08Pc_1738 Rna rnp-1 28,06Pc_745 Sterol regulatory element-binding protein ecm22 28,03Pc_7620 Fad- 27,97Pc_4286 Lysosomal cobalamin transporter 27,95Pc_2989 Penicillin-binding protein 27,90Pc_11843 --- n/a --- 27,90Pc_10940 26s proteasome non-atpase regulatory subunit 4 27,90Pc_4426 Kynurenine 3-monooxygenase 27,90Pc_5131 Hypothetical protein mac_06907 27,90Pc_3156 Ohcu decarboxylase 27,90Pc_5564 Hypothetical protein maa_09865 27,90Pc_10603 Acetamidase 27,90Pc_2433 Predicted protein 27,90Pc_6449 High mobility group protein 27,90Pc_79 Zinc c2h2 type domain containing protein 27,87Pc_1425 Short chain 27,85Pc_5145 Hypothetical protein mac_06651 27,85Pc_7435 Formamidase 27,83

Pc_8202 Dolichyl-diphosphooligosaccharide-protein glycotransferase 27,82Pc_3726 Mitochondrial peroxiredoxin prx1 27,77Pc_5921 Hypothetical protein maa_03123 27,75Pc_9620 Bifunctional purine biosynthesis protein 27,75Pc_2423 Prenylated rab acceptor 1 27,74Pc_1508 Serine threonine-protein kinase 27,71Pc_551 Trypsin-like protease 27,69Pc_11119 Reverse transcriptase 27,69Pc_4450 Kinesin light chain 27,67Pc_2072 Pyridine nucleotide-disulfide oxidoreductase amid- 27,57Pc_3383 Negative acting factor 27,54Pc_11340 Hypothetical protein maa_04747 27,54Pc_6988 Glycoside hydrolase family 17 protein 27,52Pc_1406 Short chain dehydrogenase reductase 27,51Pc_974 Syntaxin ufe1 27,43Pc_4999 Hypothetical protein mac_09682 27,42Pc_4745 Ice nucleation protein 27,42Pc_2537 Potassium transporter 27,41Pc_9937 Anucleate primary sterigmata protein a 27,40Pc_2902 Peroxisomal adenine nucleotide transporter 1 27,37Pc_3058 P60-like cell-wall 27,36Pc_7354 Fungal specific transcription factor 27,28Pc_11002 -trehalose-phosphate synthase 27,25Pc_10933 26s proteasome regulatory subunit rpn9 27,24Pc_4241 Major facilitator superfamily transporter 27,21Pc_4442 Kinesin-ii 95 kda subunit 27,20Pc_7165 Glucosamine 6-phosphate synthetase 27,17Pc_8954 Chloride channel protein 3 27,16Pc_1023 Sulfide quinone 27,16Pc_6475 Hex2 protein 27,16Pc_7578 Family regulatory 27,14Pc_2431 Predicted protein 27,13Pc_1610 Sec7 domain-containing protein 27,13Pc_20 Zinc-containing alcohol 27,11Pc_4555 Involucrin repeat protein 27,10Pc_8528 Cytochrome p450 monooxygenase 27,10Pc_3232 Nuclear transcription factor y subunit b-3 27,08Pc_432 Ubiquitin-conjugating enzyme 27,08Pc_11974 --- n/a --- 27,08Pc_2732 Phospholipase c 27,02Pc_3355 Nicotinamide riboside kinase 1 27,01Pc_10232 Alpha-ketoglutarate-dependent sulfonate dioxygenase 26,98Pc_747 Zn 2cys6 transcription factor 26,98Pc_8285 Dna repair protein 26,97Pc_6812 Glycosyltransferase family 24 protein 26,95Pc_7317 Fungal transcriptional regulatory protein 26,94Pc_7834 Eukaryotic peptide chain release factor gtp-binding subunit 26,94Pc_7012 Glycoside hydrolase 26,93Pc_2353 Protein 26,91Pc_10868 3-ketosteroid reductase 26,91Pc_10299 Alpha and gamma adaptin binding protein p34 26,88

Pc_10500 Activator of hsp90 atpase 1 family protein 26,85Pc_823 Tpa: arylamine n-acetyltransferase 2 26,84Pc_1895 Riboflavin synthase alpha chain 26,80Pc_13 Zip zinc transporter 26,80Pc_8515 Cytomegalovirus gh-receptor family 26,77Pc_9686 Benzoate 4-monooxygenase cytochrome p450 26,73Pc_4138 Mediator of rna polymerase ii transcription subunit 14 26,69Pc_2399 Proline rich protein 5 26,69Pc_8018 Duf866 domain-containing protein 26,69Pc_8052 Duf543 domain protein 26,69Pc_2794 Phosphatidate cytidylyltransferase family protein 26,69Pc_10550 Acetyltransferase catalytic subunit 26,65Pc_9431 C6 transcription 26,65Pc_9263 Calcium dependent mitochondrial carrier protein 26,65Pc_1491 Serine threonine-protein kinase rio1 26,64Pc_1117 Striatin pro11 26,64Pc_7019 Glycogen synthase 26,61Pc_10630 Abc transporter 26,59Pc_8405 Dienelactone hydrolase family protein 26,59Pc_4849 Hypothetical protein triatdraft_89282 26,58Pc_3572 Myosin class ii heavy chain 26,58Pc_4215 Major facilitator superfamily transporter 26,57Pc_6721 Gnat family 26,56Pc_5471 Hypothetical protein mac_01169 26,56Pc_5819 Hypothetical protein maa_04878 26,52Pc_4105 Membrane protein 26,49Pc_10004 Ankyrin repeat protein nuc-2 26,49Pc_10824 40 kda peptidyl-prolyl cis-trans isomerase 26,47Pc_12093 --- n/a --- 26,46Pc_2161 Protein mitochondrial targeting protein 26,43Pc_7733 F-box domain protein 26,39Pc_8527 Cytochrome p450 monooxygenase 26,37Pc_648 Translocation protein sec62 26,37Pc_1019 Sulfite reductase flavoprotein component 26,36Pc_8186 Domain-containing histone demethylation protein 3d 26,36Pc_3678 Molybdenum cofactor synthesis protein 2b 26,36Pc_3425 Nadph dehydrogenase 26,34Pc_10708 60s ribosomal protein l5 26,33Pc_4604 Integral membrane protein 26,33Pc_5716 Hypothetical protein maa_06462 26,31Pc_10815 40s ribosomal protein s17 26,31Pc_1200 Vacuolar targeting protein 26,29Pc_10111 Amp dependent 26,23Pc_2958 Peptidase family m3 26,23Pc_4738 Igr protein domain-containing protein 26,23Pc_12069 --- n/a --- 26,23Pc_1334 Short-chain dehydrogenase 26,23Pc_5259 Hypothetical protein mac_04810 26,18Pc_7443 Fms interacting 26,18Pc_3225 Nucleolar complex protein 26,16Pc_5552 Hypothetical protein maa_10244 26,16

Pc_3163 O-methyltransferase b 26,15Pc_11293 Hypothetical protein mac_02206 26,12Pc_2026 Rab gdp-dissociation inhibitor 26,12Pc_10686 Pc19g00320 26,09Pc_3595 Mutator-like element 26,08Pc_7625 Fad dependent oxidoreductase superfamily 26,07Pc_6262 Hypothetical protein acla_097710 26,01Pc_10545 Acid 26,01Pc_8193 Domain protein 25,99Pc_7088 Glutathione s- 25,98Pc_5742 Dynamin family protein 25,98Pc_8590 Cytochrome p450 25,97Pc_330 Urease accessory protein 25,93Pc_7629 Fad dependent oxidoreductase superfamily 25,92Pc_4718 Increased loss of mitochondrial dna protein 1 25,84Pc_1909 Rho-type gtpase-activating protein 25,83Pc_623 Transposase-like protein 25,82Pc_9447 C6 transcription 25,81Pc_9522 C2h2 finger domain 25,79Pc_3111 Origin recognition complex subunit 6 25,78Pc_6707 Golgi complex component 25,75Pc_4028 Methylenetetrahydrofolate reductase 1 25,75Pc_4353 Leucine rich repeat protein 25,73Pc_7990 E1-like activating enzyme 25,72Pc_2910 Peroxin 20 25,71Pc_4690 Inosine-5 -monophosphate dehydrogenase imd2 25,71Pc_10226 Alpha-methylacyl- racemase 25,70Pc_4045 Methionine aminopeptidase 1 25,70Pc_1494 Serine threonine-protein kinase ppk30 25,65Pc_9526 C2h2 finger domain 25,63Pc_3436 Nadp-dependent alcohol dehydrogenase 25,57Pc_10375 Alcohol dehydrogenase ii 25,57Pc_2104 Proteophosphoglycan 5 25,57Pc_11526 --- n/a --- 25,57Pc_29 Zinc-binding dehydrogenase 25,57Pc_2125 Protein transport protein 25,55Pc_340 Urb2 npa2 family protein 25,55Pc_6577 Heat shock protein 70-like protein 25,55Pc_6633 Guanine deaminase 25,52Pc_3335 Nitric oxide dioxygenase 25,52Pc_86 Vacuolar protein sorting-associated protein 72 like protein 25,51Pc_589 Triose-phosphate transporter 25,47Pc_8543 Cytochrome p450 alkane 25,45Pc_10251 Alpha- -mannosyltransferase cmt1 25,44Pc_8569 Cytochrome p450 25,43Pc_10402 Alanine racemase 25,41Pc_4465 Kinase-related protein 25,36Pc_3650 Mrna cleavage and polyadenylation specificity factor complex subunit 25,36Pc_10031 Ankyrin repeat protein 25,35Pc_10735 60s ribosomal protein l18 25,31Pc_8537 Cytochrome p450 alkane hydroxylase 25,27

Pc_9828 Aspartate--trna ligase 25,25Pc_359 Upf0132 domain protein 25,22Pc_3329 Nitrilase family protein 25,20Pc_1341 3-oxoacyl-(acyl carrier protein) reductase 25,19Pc_7534 Ferric reductase 25,18Pc_10032 Ankyrin repeat protein 25,18Pc_7424 Frg1-like family protein 25,17Pc_8744 Cral trio domain-containing protein 25,17Pc_1979 Regulator of g-protein signaling 25,11Pc_10901 3-dehydroshikimate dehydratase 25,05Pc_3711 Mitochondrial ribosomal protein l44 25,05Pc_6543 Heparan n-sulfatase 25,00Pc_2861 Pfs domain-containing protein 24,97Pc_3741 Mitochondrial inheritance component mdm10 24,96Pc_1712 Rrna processing protein 24,94Pc_11882 --- n/a --- 24,88Pc_1759 Rna polymerase ii transcription elongation factor 24,88Pc_7195 Phthalate transporter 24,84Pc_2645 Pi31 proteasome regulator 24,84Pc_7044 Glycerol dehydrogenase 24,80Pc_10685 Pc20g01740 24,80Pc_4879 Hypothetical protein triatdraft_156019 24,80Pc_7580 Family protein 24,80Pc_7035 Glycerol-3-phosphate o-acyltransferase 24,78Pc_1085 Succinate semialdehyde dehydrogenase 24,75Pc_2610 Poly polymerase 24,75Pc_3866 Mfs transporter 24,74Pc_3209 Nucleoside 24,74Pc_2258 Protein 24,72Pc_10364 Aldehyde dehydrogenase 24,69Pc_4779 Hypothetical protein trividraft_83765 24,69Pc_1159 Transport protein particle subunit trs31 24,68Pc_4662 Integral membrane 24,65Pc_7891 Enoyl- hydratase isomerase family protein 24,64Pc_11252 Hypothetical protein mac_08386 24,62Pc_167 Wd repeat-containing protein 24,62Pc_2054 Pyruvate decarboxylase 24,59Pc_994 Transcription regulatory protein snf5 24,59Pc_2490 Pre-mrna-splicing factor cwc25 24,55Pc_5040 Hypothetical protein mac_08792 24,55Pc_3008 Patatin-like serine 24,55Pc_324 Uridine kinase 24,55Pc_1451 Set domain-containing protein 24,55Pc_7212 Adp-ribosylation factor 24,55Pc_1813 Ring finger ubiquitin ligase 24,52Pc_6428 Histidine kinase 24,51Pc_5628 Hypothetical protein maa_08537 24,49Pc_111 Xanthine dehydrogenase 24,48Pc_11378 Hypothetical protein foxb_15595 24,46Pc_1865 Ribosomal protein cytosolic 24,43Pc_5429 Hypothetical protein mac_01793 24,42

Pc_10344 Aldo keto reductase 24,41Pc_10729 60s ribosomal protein l20 24,41Pc_8395 Dihydrodipicolinate synthetase family protein 24,40Pc_10962 2-nitropropane dioxygenase 24,40Pc_1581 Secretory 24,39Pc_2043 Pyruvate kinase 24,39Pc_11373 Hypothetical protein foxb_17746 24,37Pc_3155 Oleate-induced peroxisomal protein 24,36Pc_3477 Nadh kinase pos5 24,35Pc_4575 Integral membrane protein duf6 24,32Pc_8126 Duf1237 domain-containing protein 24,32Pc_202 Protein fat-free like protein 24,29Pc_1087 Succinate dehydrogenase iron-sulfur protein 24,29Pc_986 Sybindin-like family protein 24,27Pc_11576 --- n/a --- 24,27Pc_11 Zn 2cys6 transcription factor 24,26Pc_3787 Mitochondrial carrier protein yhm1 24,25Pc_2837 Phd finger domain 24,23Pc_11495 --- n/a --- 24,23Pc_11844 --- n/a --- 24,20Pc_5157 Hypothetical protein mac_06397 24,20Pc_1896 Riboflavin kinase 24,19Pc_3391 Nedd8-like protein 24,18Pc_11023 -dimethylguanosine trna methyltransferase 24,14Pc_10255 Alpha- -mannosidase family protein 24,12Pc_11013 -like family protein 24,07Pc_1875 Ribose 5-phosphate isomerase a 24,03Pc_2525 Pq loop repeat protein 24,00Pc_2073 Pyridine nucleotide-disulfide 24,00Pc_3766 Mitochondrial dynamin gtpase 23,99Pc_1453 Lysine methyltransferase 23,98Pc_10237 Alpha-glucosides permease mph2 3 23,96Pc_1277 Lsm domain-containing protein 23,95Pc_6547 Hemerythrin hhe cation binding domain-containing protein 23,94Pc_5725 Hypothetical protein maa_06285 23,94Pc_8275 Dna repair protein rad50 23,93Pc_973 Tachykinin family protein 23,91Pc_5810 Hypothetical protein maa_04960 23,91Pc_9766 Atp-dependent permease mdl2 23,90Pc_114 Aminopeptidase ypdf 23,90Pc_10014 Ankyrin repeat protein 23,88Pc_264 Vacuolar protein sorting-associated protein 35 23,87Pc_8438 Denitrification regulatory protein nirq 23,87Pc_2020 Rad21 rec8 n terminal domain-containing protein 23,86Pc_4680 Inositol polyphosphate 23,86Pc_10787 5-aminolevulinate synthase 23,85Pc_3728 Mitochondrial outer membrane protein mmm1 23,84Pc_3646 Mrna processing protein 23,84Pc_9820 Aspartic-type endopeptidase 23,83Pc_10748 60s ribosomal biogenesis protein 23,82Pc_4226 Major facilitator superfamily transporter 23,79

Pc_10982 2 protein 23,78Pc_10948 26s protease regulatory subunit 4 23,77Pc_1125 Stress response protein nst1 23,74Pc_11733 --- n/a --- 23,72Pc_8930 Cholinesterase precursor 23,70Pc_5106 Hypothetical protein mac_07268 23,70Pc_4205 Major facilitator superfamily transporter 23,68Pc_10665 Aaa family atpase 23,67Pc_9451 C6 transcription 23,66Pc_11633 --- n/a --- 23,61Pc_3469 Nadh-dependent flavin oxidoreductase 23,61Pc_7953 Electron transfer flavoprotein-ubiquinone oxidoreductase 23,61Pc_9025 Cell wall protein 23,53Pc_9584 Bromodomain containing protein 23,53Pc_5860 Hypothetical protein maa_04107 23,53Pc_2011 Ran exchange factor prp20 23,52Pc_3906 Mfs multidrug transporter 23,51Pc_10062 Ankyrin repeat domain-containing protein 28 23,50Pc_3243 Nuclear pore complex subunit nup85 23,50Pc_6425 Histidine kinase 23,49Pc_6438 Hisactophilin c49s mutant phototropin phy3 fusion protein 23,49Pc_454 Ubiquitin conjugation factor e4 23,48Pc_2994 Penicillin-binding 23,47Pc_4030 Methylenetetrahydrofolate dehydrogenase 23,47Pc_4356 Leucine rich repeat domain protein 23,46Pc_1819 Ring finger domain-containing protein 23,43Pc_10252 Alpha- -mannosyltransferase alg11 23,43Pc_11849 --- n/a --- 23,43Pc_9793 Atp synthase h chain 23,43Pc_9747 Atp-dependent rna helicase dhx8 23,38Pc_2339 Protein 23,38Pc_8095 Duf1746-domain-containing protein 23,37Pc_10913 3-beta hydroxysteroid dehydrogenase 23,37Pc_10408 Aif-like mitochondrial oxidoreductase 23,37Pc_12056 --- n/a --- 23,35Pc_10321 Alkbh6 protein 23,34Pc_836 Topoisomerase 1-associated factor 1 23,34Pc_604 Triacylglycerol lipase 23,31Pc_4042 Methionine vitamin-b12 23,31Pc_717 Transcription initiation factor tfiid subunit 13 23,31Pc_9549 Bzip transcription factor 23,31Pc_5213 Mfs transporter 23,31Pc_8061 Duf396 domain protein 23,27Pc_7098 Glutamyl-trna synthetase 23,27Pc_10089 Anion exchange 23,27Pc_5885 Hypothetical protein maa_03853 23,26Pc_8380 Dihydroxy-acid 23,26Pc_7360 Fungal specific transcription 23,25Pc_7301 Fungal zn binuclear cluster domain containing protein 23,23Pc_176 Coronin-like protein crn1 23,22Pc_10625 Abc transporter 23,22

Pc_11372 Hypothetical protein glarea_01861 23,21Pc_7500 Filamentation protein 23,21Pc_11904 --- n/a --- 23,20Pc_8751 Cral trio domain protein 23,18Pc_10362 Aldehyde dehydrogenase 23,18Pc_12057 Ankyrin repeat protein 23,18Pc_7863 Er to golgi protein transport 23,17Pc_1999 Ras guanyl-nucleotide exchange factor 23,16Pc_4371 Lccl domain containing protein 23,16Pc_12035 --- n/a --- 23,16Pc_8747 Cral trio domain protein 23,16Pc_155 Wd domain-containing protein 23,13Pc_9861 Arsenite efflux transporter - puative 23,13Pc_4501 Jumonji domain containing 2d 23,12Pc_1607 Secreted aspartic proteinase 23,12Pc_1145 Srp40 domain-containing protein 23,10Pc_6319 Hormone-sensitive lipase 23,08Pc_3205 Nucleoside-diphosphate sugar epimerase 23,07Pc_7342 Fungal specific transcription factor domain-containing protein 23,06Pc_7334 Fungal specific transcription factor domain-containing protein 23,06Pc_1739 Rna recognition motif-containing protein 23,05Pc_2100 Protoporphyrinogen oxidase 23,04Pc_10552 Acetyltransferase 23,02Pc_8606 Cytochrome c1 heme lyase 22,99Pc_9847 Arylsulfatase precursor 22,99Pc_8290 Dna repair helicase rad25 22,98Pc_9778 Atp-binding endoribonuclease 22,96Pc_2885 Peroxisomal membrane protein pex31 22,94Pc_8320 Dna mismatch repair protein 22,92Pc_7404 Fumarylacetoacetase 22,89Pc_1114 Mitochondrial acidic protein mam33 22,89Pc_9076 Cell cycle inhibitor 22,86Pc_8732 Ctlh domain-containing protein 22,84Pc_7756 Extracellular serine-rich protein 22,84Pc_9470 Ring-4 protein 22,83Pc_11621 --- n/a --- 22,83Pc_6594 Hcngp-like protein 22,81Pc_9843 Asparaginase-like protein 22,80Pc_6301 Hsp70 protein 22,77Pc_3794 Mitochondrial carrier protein 22,73Pc_11847 --- n/a --- 22,73Pc_2113 Protein-er retention protein 22,73Pc_6010 Hypothetical protein maa_01773 22,73Pc_3531 Nacht and ankyrin domain protein 22,73Pc_9397 C6 transcription 22,69Pc_1584 Secretory 22,69Pc_7472 Flavin-binding monooxygenase-like protein 22,64Pc_23 Zinc-binding oxidoreductase 22,60Pc_3349 Nima-interacting protein 22,55Pc_10139 Amino-acid permease inda1 22,52Pc_1012 Superoxide dismutase 22,52

Pc_10884 3-hydroxyisobutyrate dehydrogenase 22,51Pc_2957 Peptidase family m49 22,45Pc_3028 Pantothenate kinase 22,44Pc_5282 Hypothetical protein mac_04331 22,41Pc_10359 Aldehyde dehydrogenase 22,41Pc_10204 Amidase family protein 22,40Pc_6829 Glycosyltransferase family 15 protein 22,40Pc_16 Zinc-regulated transporter 1 22,38Pc_9535 C2 domain containing protein 22,36Pc_8072 Duf255 domain protein 22,35Pc_75 Zinc finger 22,35Pc_9064 Cell division control protein 12 22,32Pc_6918 Glycoside hydrolase family 5 protein 22,32Pc_1970 Related to amidase 22,32Pc_5031 Hypothetical protein mac_08976 22,28Pc_4603 Integral membrane protein 22,28Pc_5292 Hypothetical protein mac_04232 22,22Pc_10804 40s ribosomal protein s27 22,19Pc_11190 Hypothetical protein 22,19Pc_11042 --- n/a --- 22,12Pc_3551 N-terminal amidase 22,07Pc_3234 Nuclear segregation protein 22,06Pc_6998 Glycoside hydrolase family 16 22,05Pc_6679 Gpi-anchored cell wall organization protein ecm33 22,03Pc_2493 Pre-mrna-splicing factor cef-1 22,03Pc_1893 Riboflavin transporter mch5 22,01Pc_9871 Arrestin (or s-antigen) 22,01Pc_5484 Hypothetical protein mac_00849 22,00Pc_7319 Fungal transcriptional regulatory protein 21,96Pc_3290 Nonribosomal peptide synthetase 6 21,95Pc_1830 Ribulose-phosphate 3-epimerase 21,92Pc_7378 Fungal specific transcription 21,92Pc_2491 Pre-mrna-splicing factor cwc21 21,92Pc_1801 Ring-box protein 1 21,92Pc_1302 Signal recognition particle sec65 subunit 21,92Pc_4195 Malate dehydrogenase 21,92Pc_6571 Heat shock protein mitochondrial precursor 21,92Pc_1077 Succinyl- ligase alpha-chain 21,92Pc_9765 Atp-dependent protease 21,89Pc_1312 Siderophore iron transporter mirb 21,88Pc_2995 Penicillin-binding 21,88Pc_10123 Aminopeptidase y 21,88Pc_3918 Mfs multidrug 21,88Pc_10165 Amino acid 21,83Pc_2239 Protein disulfide isomerase 21,83Pc_7771 Extracellular dipeptidyl-peptidase dpp4 21,83Pc_8375 Dihydroxyacetone kinase 21,81Pc_7811 Eukaryotic translation initiation factor 3 subunit l 21,79Pc_12067 --- n/a --- 21,77Pc_7373 Fungal specific transcription 21,75Pc_7910 Endosomal integral membrane protein 21,75

Pc_6909 Glycoside hydrolase family 55 protein 21,75Pc_8016 Duf89 domain-containing protein 21,74Pc_1690 Rta1 domain protein 21,73Pc_11948 --- n/a --- 21,73Pc_4721 Importin-beta domain containing protein 21,71Pc_8278 Dna repair protein rad26 21,70Pc_7955 Electron transfer flavoprotein beta-subunit 21,70Pc_9716 Autophagy protein 5 21,66Pc_10466 Acyl-protein thioesterase 21,63Pc_10912 3-beta hydroxysteroid dehydrogenase 21,60Pc_9543 C-4 methylsterol oxidase 21,58Pc_9952 Ankyrin unc44 21,56Pc_673 Elongation factor g 21,55Pc_10614 Abc1 domain containing protein 21,44Pc_3138 Oligopeptide transporter opt-like protein 21,42Pc_10801 40s ribosomal protein s3 21,41Pc_305 Vacuolar atp synthase 16 kda proteolipid subunit 21,41Pc_12071 --- n/a --- 21,41Pc_8619 Cytochrome c oxidase assembly protein 21,41Pc_2744 Phosphoglycerate mutase family protein 21,38Pc_8468 Ddhd domain-containing protein 21,34Pc_4096 Membrane zinc transporter 21,34Pc_8769 Copii coat assembly protein sec16 21,33Pc_9928 Ap-2 complex subunit sigma 21,31Pc_8465 Deacetylase complex subunit 21,31Pc_932 Terpene synthase family protein 21,29Pc_3090 Oxidoreductase 21,29Pc_6768 Glycosyltransferase family protein 21,27Pc_4247 Major facilitator superfamily transporter 21,27Pc_3309 Non-hemolytic phospholipase c 21,27Pc_1733 Rna-binding protein 21,27Pc_2408 Proliferating cell nuclear antigen 21,25Pc_6584 Heat shock protein 21,22Pc_10140 Amino-acid permease inda1 21,20Pc_3165 O-methyltransferase 21,17Pc_9158 Carboxyphosphonoenolpyruvate 21,17Pc_5461 Hypothetical protein mac_01306 21,12Pc_5025 Hypothetical protein mac_09078 21,11Pc_4291 Lysophospholipase like protein 21,11Pc_9113 Cation efflux family 21,10Pc_1139 Steroid 5 alpha-reductase 21,09Pc_3502 Nad dependent epimerase dehydratase 21,08Pc_7066 Glutathione s-transferase family 21,08Pc_10037 Ankyrin repeat protein 21,07Pc_9613 Biotin apo-protein 21,07Pc_9221 Capsule-associated protein 21,07Pc_1430 Sh3 domain-containing protein 21,04Pc_9798 Atp synthase d mitochondrial 21,04Pc_2085 Purine-cytosine permease 21,04Pc_2551 Pos9-activating factor fap7 21,02Pc_534 Tubulin-tyrosine ligase 21,00

Pc_1377 Short chain dehydrogenase 21,00Pc_5452 Hypothetical protein mac_01496 21,00Pc_3244 Nuclear pore complex subunit nup159 20,99Pc_7599 Family protein 20,98Pc_1126 Stress response protein 20,96Pc_8364 Dimethylaniline monooxygenase 2 20,95Pc_4831 Hypothetical protein trividraft_197327 20,94Pc_4817 Hypothetical protein trividraft_216595 20,92Pc_10546 Achain x-ray crystallographic and calorimeric studies of the effects of the m 20,92Pc_9706 Auxin efflux carrier superfamily 20,90Pc_462 Ubiquitin carboxyl-terminal hydrolase 19 20,89Pc_9796 Atp synthase f0 20,88Pc_6064 Hypothetical protein maa_00533 20,87Pc_5780 Hypothetical protein maa_05382 20,87Pc_1241 Snare domain-containing protein 20,84Pc_465 Ubiquitin carboxyl-terminal hydrolase 20,84Pc_4983 Hypothetical protein mgyg_00399 20,84Pc_1679 S-adenosyl-l-methionine-dependent methyltransferase 20,83Pc_6247 Hypothetical protein ani_1_516044 20,81Pc_9139 Casein kinase ii beta 2 subunit 20,78Pc_1834 Ribosome biogenesis protein rrp14-c 20,76Pc_4198 Mak32 protein 20,76Pc_2513 Pre-mrna splicing factor atp-dependent rna helicase prp16 20,75Pc_2789 Phosphatidylcholine-sterol o-acyltransferase-like protein 20,75Pc_6654 Gtp-binding protein obg 20,74Pc_394 Udp-glucose 4-epimerase gal10 20,71Pc_11759 --- n/a --- 20,69Pc_3653 Mrna binding post-transcriptional regulator 20,69Pc_5086 Hypothetical protein mac_07660 20,69Pc_10535 Acid phosphatase 20,69Pc_4563 Intracellular serine protease 20,67Pc_7486 Flavin-binding monooxygenase 20,67Pc_11156 Porphobilinogen deaminase 20,66Pc_1955 Related to ribosomal protein mitochondrial 20,66Pc_10248 Alpha-acetolactate decarboxylase 20,63Pc_5469 Hypothetical protein mac_01189 20,63Pc_8120 Duf1275 domain protein 20,61Pc_5727 Hypothetical protein maa_06254 20,61Pc_7528 Ferric reductase transmembrane 20,60Pc_11705 --- n/a --- 20,60Pc_8039 Duf636 domain-containing protein 20,60Pc_2134 Protein required for cell 20,59Pc_8362 Dimethylaniline monooxygenase 2 20,58Pc_1116 Stromal membrane-associated protein 20,57Pc_7885 Epl1-like protein 20,57Pc_10045 Ankyrin repeat protein 20,55Pc_9934 Ap-1 complex subunit gamma-1 20,54Pc_1227 Snf7 family protein 20,51Pc_936 Telomere silencing protein 20,50Pc_1457 Seryl-trna synthetase 20,49Pc_10898 3-hydroxy-3-methylglutaryl-coenzyme a reductase 20,46

Pc_1719 Rpel repeat protein 20,46Pc_8972 Chip protein (carboxyl terminus of hsc70-interacting protein) 20,46Pc_7407 Fumarate reductase 20,46Pc_10654 Abc efflux transporter 20,41Pc_3211 Nucleoporin nup49 nsp49 20,41Pc_9544 C-3 sterol dehydrogenase c-4 decarboxylase family protein 20,40Pc_4941 Hypothetical protein nechadraft_87583 20,40Pc_8105 Duf1665 domain-containing protein 20,39Pc_5702 Hypothetical protein maa_06779 20,39Pc_2558 Polysaccharide lyase family 8 protein 20,38Pc_4960 Hypothetical protein nechadraft_45421 20,38Pc_6068 Hypothetical protein maa_00387 20,37Pc_11443 Cyclin-like f-box 20,37Pc_2090 Pumilio-family rna binding repeat protein 20,37Pc_7476 Flavin-binding monooxygenase-like family protein 20,35Pc_3782 Mitochondrial chaperone bcs1 20,34Pc_7978 Ectonucleotide pyrophosphatase phosphodiesterase family member 1 20,32Pc_5688 Hypothetical protein maa_07096 20,32Pc_736 Transcription factor tfiia complex subunit 20,31Pc_7760 Extracellular scp domain protein 20,29Pc_3652 Mrna cap methyltransferase 20,29Pc_2313 Protein 20,28Pc_11220 Hypothetical protein ss1g_14392 20,23Pc_5509 Hypothetical protein mac_00467 20,23Pc_8203 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kda subun 20,23Pc_7335 Fungal specific transcription factor domain-containing protein 20,23Pc_5397 Hypothetical protein mac_02327 20,22Pc_10678 A chain crystal structure of cyclin-dependent kinase 2 with inhibitor 20,21Pc_8085 Duf1941 family protein 20,20Pc_6876 Glycoside hydrolase family 79 protein 20,18Pc_7427 Frequency clock protein 20,18Pc_5467 Hypothetical protein mac_01208 20,15Pc_1485 Serine threonine-protein kinase sgk2 20,14Pc_2411 Progesterone binding protein 20,12Pc_11254 Hypothetical protein mac_08268 20,12Pc_1156 Spt2 chromatin protein 20,12Pc_8371 Dil and ankyrin domain containing protein 20,09Pc_3104 Orotidine-5 -phosphate decarboxylase 20,07Pc_6090 Hypothetical protein hmpref1120_05153 20,06Pc_2292 Protein 20,06Pc_9135 Casein kinase phosphoprotein pp28 20,04Pc_5468 Hypothetical protein mac_01197 20,04Pc_3930 Mfs multidrug 20,04Pc_8373 Dihydroxyacetone kinase 20,04Pc_743 Zn2 cys6 dna-binding protein 20,03Pc_9603 Bmr1-like protein 20,03Pc_8109 Duf1604 domain protein 20,02Pc_10097 And ankyrin domain protein 20,00Pc_7678 Fad binding domain protein 19,99Pc_152 Wd tetratricopeptide repeat domain-containing protein 19,98Pc_4472 Killer toxin sensitivity protein 19,98

Pc_5522 Hypothetical protein mac_00278 19,89Pc_3222 Nucleolar essential protein 1 19,86Pc_1740 Rna recognition motif containing protein 19,86Pc_2045 Pyruvate formate lyase activating enzyme 19,85Pc_8846 Coiled-coil domain-containing protein 16 19,85Pc_3660 Mosc domain-containing protein 19,80Pc_4271 Macro domain-containing protein 19,80Pc_9085 Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis 19,80Pc_4079 Metallo-beta-lactamase family protein 19,80Pc_11167 Pectinesterase precursor 19,80Pc_9745 Atp-dependent rna helicase drs1 19,80Pc_49 Zinc finger protein 2 19,77Pc_694 Transcriptional regulator 19,77Pc_504 U2 snrnp component prp10 19,75Pc_1412 Retinol dehydrogenase 8 19,75Pc_10009 Ankyrin repeat protein 19,69Pc_10435 Adp-ribose 1 -phosphate phosphatase 19,69Pc_44 Peptidase family m48 19,69Pc_1617 Sds23 moc1 19,68Pc_12106 --- n/a --- 19,67Pc_2526 Pq loop repeat protein 19,66Pc_2205 Protein kinase domain-containing protein 19,66Pc_1595 Secreted protein 19,64Pc_7428 Frequency clock protein 19,64Pc_10345 Aldo keto reductase 19,61Pc_6624 Guanine nucleotide-binding protein alpha-3 subunit 19,61Pc_5219 Hypothetical protein mac_05471 19,59Pc_9864 Arsenate reductase 19,59Pc_6074 Hypothetical protein maa_00286 19,59Pc_12007 --- n/a --- 19,58Pc_3220 Nucleolar gtp-binding protein 2 19,49Pc_958 Tat pathway signal sequence 19,47Pc_9947 Annexin anxc4 19,47Pc_11608 --- n/a --- 19,45Pc_6390 Histone deacetylase 19,45Pc_8928 Chorion transcription factor cf2 19,44Pc_10843 37s ribosomal protein s12 19,42Pc_11958 --- n/a --- 19,42Pc_9235 Camp-mediated signaling protein sok1 19,41Pc_6706 Golgi integral membrane protein 19,41Pc_518 Protein-tyrosine phosphatase 19,38Pc_785 Tpr repeat protein 19,37Pc_9409 C6 transcription 19,35Pc_8169 Domain-containing protein 19,33Pc_11999 --- n/a --- 19,33Pc_2495 Pre-mrna-splicing factor 38b 19,32Pc_10581 Acetolactate synthase small subunit 19,30Pc_10283 Alpha beta hydrolase family protein 19,30Pc_3962 Mfs hexose 19,29Pc_2933 Peptidoglycan binding domain containing protein 19,29Pc_2405 Proline oxidase 19,29

Pc_7447 Fmi2 protein 19,29Pc_10908 3-carboxy- -muconate cyclase 19,29Pc_5234 Hypothetical protein mac_05147 19,28Pc_5220 Hypothetical protein mac_05447 19,28Pc_6088 Hypothetical protein hmpref1120_07571 19,27Pc_11003 -transferase family iii 19,25Pc_5504 Hypothetical protein mac_00522 19,25Pc_9424 C6 transcription 19,24Pc_2850 Ph domain-containing protein 19,23Pc_3183 Nudix family 19,20Pc_5239 Hypothetical protein mac_05055 19,18Pc_8087 Duf1857 domain containing protein 19,18Pc_4310 Long-chain-fatty-acid-- ligase faa2 19,15Pc_1006 Suppressor protein srp40 19,15Pc_11836 --- n/a --- 19,13Pc_5165 Hypothetical protein mac_06335 19,11Pc_10773 50s ribosomal protein l27 19,11Pc_5322 Hypothetical protein mac_03685 19,10Pc_5466 Hypothetical protein mac_01231 19,08Pc_688 Transcriptional regulator cwf13 19,08Pc_2939 Peptide chain release factor 1 19,08Pc_4470 Kinase domain containing protein 19,07Pc_1486 Serine threonine-protein kinase sgk2 19,06Pc_9226 Capsular associated protein 19,06Pc_308 Amino acid 19,05Pc_7832 Eukaryotic ribosome biogenesis protein 1 19,05Pc_1498 Serine threonine-protein kinase ksg1 19,03Pc_4969 Hypothetical protein nechadraft_123303 19,03Pc_4430 Ku70 protein 19,00Pc_7685 Fad binding domain containing protein 19,00Pc_7051 Glutathione-independent formaldehyde dehydrogenase 18,98Pc_7038 Glycerol-3-phosphate dehydrogenase 18,98Pc_7803 Eukaryotic translation initiation factor eif-2b subunit 3 18,96Pc_9090 Cdc24 calponin 18,91Pc_2449 Predicted protein 18,91Pc_6682 Gpi transamidase subunit pig-u 18,91Pc_8913 Chromosomal organization and dna repair protein 18,89Pc_7770 Extracellular elastinolytic metalloproteinase 18,89Pc_8091 Duf1766-domain-containing protein 18,86Pc_6656 Gtp-binding protein gtr1 18,86Pc_9121 Catechol dioxygenase 18,85Pc_7207 General amino acid permease 18,83Pc_8045 Duf636 domain protein 18,83Pc_2778 Phosphatidylinositol-specific phospholipase 18,82Pc_3608 Multidrug resistant protein 18,82Pc_8323 Dna methyltransferase dim-2 18,80Pc_5634 Hypothetical protein maa_08420 18,77Pc_2727 Phospholipase carboxylesterase superfamily 18,76Pc_4102 Membrane transporter 18,74Pc_159 Wd repeat-containing protein 18,74Pc_10606 Acc synthase 18,73

Pc_3233 Nuclear serine protease 2 18,71Pc_8081 Duf221 domain 18,70Pc_6670 Gsg2 protein kinase 18,68Pc_11128 Protein 18,67Pc_5244 Hypothetical protein mac_05021 18,63Pc_10867 3-methyl-2-oxobutanoate hydroxymethyltransferase 18,60Pc_5664 Hypothetical protein maa_07466 18,60Pc_984 Snare protein snc2 18,60Pc_561 Trna wybutosine-synthesizing protein 18,60Pc_4885 Hypothetical protein thite_2131440 18,60Pc_10333 Aldose 1-epimerase 18,60Pc_11114 Sarcosine oxidase 18,60Pc_3590 Myb dna-binding domain protein 18,56Pc_7915 Endoplasmic reticulum-golgi intermediate compartment protein 3 18,56Pc_592 Anthranilate synthase component 2 18,55Pc_463 Ubiquitin carboxyl-terminal hydrolase 18,54Pc_7344 Fungal specific transcription factor domain-containing protein 18,53Pc_6869 Glycoside hydrolase family 92 protein 18,53Pc_6100 Hypothetical protein glrg_02350 18,53Pc_1163 Spo7-like protein 18,51Pc_744 Zn 2cys6 transcription factor 18,51Pc_2792 Phosphatidic acid phosphatase beta 18,51Pc_8819 Conserved hypothetical protein 18,44Pc_9317 C6 zinc finger domain protein 18,44Pc_6358 Hit zinc finger 18,43Pc_3472 Nadh-cytochrome b5 18,43Pc_1576 Secretory pathway protein 18,41Pc_5572 Hypothetical protein maa_09719 18,39Pc_7560 Fatty acid desaturase 18,37Pc_2962 Peptidase family m28 18,35Pc_3673 Monoamine oxidase n 18,34Pc_6024 Hypothetical protein maa_01420 18,32Pc_616 Transposase-like protein 18,32Pc_599 Triacylglycerol lipase fgl2 18,32Pc_8688 Cyclin domain containing protein 18,32Pc_5896 Hypothetical protein maa_03557 18,30Pc_168 Wd repeat protein 18,29Pc_6780 Glycosyltransferase family 58 protein 18,29Pc_3284 Nonsense-mediated mrna decay protein 1 18,28Pc_4149 Mating-type switching protein swi10 18,25Pc_7293 G protein beta subunit 18,25Pc_975 T-complex protein 1 subunit zeta 18,23Pc_10835 4-coumarate- ligase 18,19Pc_3191 Nudix 18,16Pc_10411 Agmatine deiminase 18,15Pc_7022 Glycogen debranching enzyme 18,15Pc_12010 --- n/a --- 18,14Pc_9073 Cell cycle regulatory protein 18,11Pc_1097 Tat pathway signal protein 18,11Pc_1667 Sac3 ganp domain protein 18,09Pc_8337 Dna damage-inducible protein 1 18,08

Pc_5042 Hypothetical protein mac_08773 18,07Pc_852 Thymidylate kinase 18,05Pc_7197 General substrate transporter 18,05Pc_6036 Hypothetical protein maa_01183 18,05Pc_12020 --- n/a --- 18,05Pc_10710 60s ribosomal protein l38 18,05Pc_2050 Pyruvate dehydrogenase e1 component beta subunit 18,05Pc_640 Transmembrane amino acid transporter family protein 18,02Pc_2849 Ph domain-containing protein 18,01Pc_8469 Ddhd domain-containing protein 18,01Pc_3476 Nadh oxidase 18,00Pc_8289 Dna repair helicase rad3 17,98Pc_9769 Atp-dependent dna helicase recq 17,96Pc_6384 Histone deacetylase rpd3 17,95Pc_10145 Amino acid transporter 17,95Pc_10693 Deha2b14894p 17,95Pc_3877 Mfs transporter 17,95Pc_7099 Glutamyl-trna synthetase 17,95Pc_3177 O- 17,93Pc_6031 Hypothetical protein maa_01254 17,92Pc_4020 Methyltransferase 17,90Pc_8115 Duf1338 domain protein 17,90Pc_10471 Acyl-coenzyme a oxidase 1 17,89Pc_2401 Proline permease 17,89Pc_6974 Glycoside hydrolase family 2 protein 17,89Pc_707 Transcriptional activator hac1 17,87Pc_5863 Hypothetical protein maa_04084 17,86Pc_350 Upf0220 domain protein 17,84Pc_10383 Alcohol dehydrogenase 17,84Pc_4290 Lysophospholipase plb1 17,82Pc_6229 Hypothetical protein ccm_00026 17,79Pc_1475 Serine threonine-protein phosphatase 2b catalytic subunit 17,76Pc_9437 C6 transcription 17,75Pc_3623 Multicopper oxidase 17,75Pc_2321 Protein 17,74Pc_2753 Phosphoglycerate mutase family 17,74Pc_5425 Hypothetical protein mac_01839 17,74Pc_2858 Pfs domain-containing protein 17,73Pc_4522 Isoepoxydon dehydrogenase 17,73Pc_12113 --- n/a --- 17,71Pc_1708 Rrna processing protein 17,71Pc_6701 Golgi reassembly-stacking protein 2 17,69Pc_327 Ureidoglycolate hydrolase 17,68Pc_3257 Nuclear fragile x mental retardation-interacting protein 1 17,68Pc_9261 Calcium influx-promoting protein ehs1 17,68Pc_7709 F-box protein 17,67Pc_10971 2-heptaprenyl- -naphthoquinone 17,66Pc_1654 Salicylate hydroxylase 17,65Pc_1276 Small nuclear ribonucleoprotein 17,64Pc_677 Rna-binding protein 17,62Pc_3480 Nad-dependent malic enzyme 17,60

Pc_9179 Carboxylesterase type b 17,60Pc_8792 Conserved hypothetical protein 17,59Pc_940 Telomerase reverse transcriptase 17,59Pc_1201 Sorting nexin mvp-1 17,58Pc_9247 Calcium-transporting atpase type 2c member 1 17,56Pc_10725 60s ribosomal protein l23 17,54Pc_6932 Glycoside hydrolase family 38 protein 17,54Pc_6001 Hypothetical protein maa_01927 17,54Pc_8517 Cytokinesis protein sepa 17,54Pc_3080 Oxidoreductase fad-binding domain-containing protein 17,54Pc_6991 Glycoside hydrolase family 16 protein 17,54Pc_7927 Endo- -beta-xylanase 17,54Pc_10779 50s ribosomal protein 27 17,54Pc_2630 Plasma membrane channel protein 17,49Pc_25 Zinc-binding oxidoreductase 17,49Pc_3364 Nf-x1 finger and helicase domain 17,49Pc_246 Valyl-trna synthetase 17,49Pc_1715 Rrna biogenesis protein rrp5 17,48Pc_3347 Nipsnap family protein 17,44Pc_5090 Hypothetical protein mac_07580 17,39Pc_2489 Pre-mrna-splicing factor isy1 17,39Pc_1423 Short chain dehydrogenase 17,39Pc_3446 Nadh-ubiquinone oxidoreductase-like protein 17,35Pc_7021 Glycogen debranching enzyme 17,35Pc_9012 Cell wall protein 17,34Pc_5887 Hypothetical protein maa_03760 17,32Pc_7734 F-box domain containing protein 17,31Pc_164 Wd repeat-containing protein 17,31Pc_10072 Ankyrin partial 17,29Pc_7115 Glutamine synthetase 17,29Pc_253 Vacuolar sorting receptor 17,26Pc_9840 Asparaginyl-trna synthetase 17,25Pc_6696 Gpi anchored 17,24Pc_6717 Gnat family 17,24Pc_11982 --- n/a --- 17,24Pc_3580 Mynd domain protein 17,24Pc_1770 Rna polymerase i specific transcription initiation factor 17,21Pc_6765 Glycylpeptide n-tetradecanoyltransferase 17,20Pc_9647 Beta-lactamase family protein 17,20Pc_3500 Nad dependent epimerase dehydratase family protein 17,19Pc_7325 Fungal transcriptional regulatory protein 17,19Pc_10523 Actin 17,19Pc_10101 Anaphase-promoting complex protein 17,18Pc_2618 Plc-like tim beta alpha-barrel domain 17,17Pc_7661 Fad binding domain-containing protein 17,17Pc_1026 Sulfate transporter 17,16Pc_9282 Ca2+ transporter 17,15Pc_5177 Hypothetical protein mac_06150 17,14Pc_307 Vacuolar assembly 17,09Pc_3369 Neutral protease 17,09Pc_4556 Involucrin repeat protein 17,09

Pc_7206 General amino acid permease 17,08Pc_441 Ubiquitin-activating enzyme uba2 17,07Pc_2774 Phosphatidylserine decarboxylase 17,07Pc_8718 Cupin domain protein 17,05Pc_5714 Hypothetical protein maa_06475 17,05Pc_5661 Hypothetical protein maa_07656 17,05Pc_11219 Hypothetical protein thite_2108207 17,05Pc_5738 Hypothetical protein maa_06084 17,05Pc_10712 60s ribosomal protein l37 17,05Pc_3214 Nucleoporin nup157 170 16,99Pc_8112 Duf1479 domain protein 16,98Pc_3171 O-methylsterigmatocystin oxidoreductase 16,98Pc_992 Swim zinc finger domain protein 16,97Pc_4459 Kinesin family protein 16,97Pc_2589 Polyketide synthase 16,97Pc_6590 Heat repeat containing protein 16,96Pc_1359 Short-chain dehydrogenase reductase 16,95Pc_8347 Dj-1 family protein 16,93Pc_6636 Gtpase-activating protein gyp7 16,89Pc_1797 Rio1 family protein 16,87Pc_2137 Protein rai1 16,86Pc_9825 Aspartic endopeptidase 16,85Pc_1105 Subtilisin-like protease pr1a 16,84Pc_3052 P60-like cell-wall 16,82Pc_3541 N2227-like protein 16,82Pc_8511 Cytoskeleton assembly control protein 16,79Pc_9318 C6 zinc finger domain protein 16,76Pc_8418 Diacylglycerol acyltransferase dgat2 16,75Pc_9078 Cell cycle control protein cdc123 16,74Pc_220 Vitamin b6 16,73Pc_9929 Ap-2 complex subunit mu-1 16,72Pc_10254 Alpha- -mannosyltransferase 16,71Pc_6244 Hypothetical protein aol_s00007g61 16,70Pc_449 Ubiquitin hydrolase 16,70Pc_11224 Hypothetical protein pdendc454_25811 16,70Pc_2416 Pro41 protein 16,70Pc_8301 Dna polymerase kappa 16,70Pc_9182 Carboxylesterase family protein 16,66Pc_758 Transcription factor atf21 16,65Pc_1369 Short-chain dehydrogenase 16,65Pc_2451 Predicted protein 16,63Pc_7907 Endosomal peripheral membrane protein 16,61Pc_4467 Kinase phosphorylation protein 16,59Pc_4050 Metallothionein-i gene transcription activator 16,59Pc_1185 Sphingosine-1-phosphate lyase 16,59Pc_67 C-x8-c-x5-c-x3-h type zinc finger protein 16,57Pc_5812 Hypothetical protein maa_04937 16,54Pc_2805 Phosducin family protein 16,53Pc_6674 Grf zinc finger domain-containing protein 16,51Pc_3497 Nad dependent epimerase dehydratase family protein 16,49Pc_953 Tat pathway signal sequence domain protein 16,49

Pc_841 Tmem1 family protein 16,48Pc_1211 Solute carrier family 12 member 3 16,45Pc_3240 Nuclear protein es2 16,44Pc_8238 Dna-directed rna polymerase ii largest subunit 16,43Pc_7936 Embryonic ectoderm development protein 16,43Pc_8626 Cytochrome b561 16,43Pc_501 U3 small nucleolar ribonucleoprotein imp4 16,42Pc_5424 Hypothetical protein mac_01881 16,41Pc_8302 Dna polymerase iota 16,40Pc_10241 Alpha-galactosidase a precursor 16,40Pc_8696 Cwf18 pre-mrna splicing factor 16,40Pc_5383 Hypothetical protein mac_02601 16,39Pc_4325 Lipase esterase 16,39Pc_1980 Regulator of g-protein signaling 16,37Pc_9007 Cellobiose dehydrogenase 16,37Pc_3444 Nadh:flavin oxidoreductase nadh oxidase family protein 16,37Pc_7777 Exportin-1 16,34Pc_2505 Pre-mrna splicing factor slt11 16,32Pc_11995 --- n/a --- 16,32Pc_1625 Sas10 utp3 family protein 16,31Pc_9491 C2h2 zinc finger protein 16,31Pc_1974 Regulatory p domain-containing protein 16,30Pc_10696 8-amino-7-oxononanoate synthase 16,30Pc_8463 Dead deah box 16,27Pc_393 Udp-glucose 4-epimerase gal10 16,26Pc_12080 --- n/a --- 16,26Pc_10537 Acid phosphatase 16,24Pc_1831 Ribosome biogenesis protein ytm1 16,23Pc_8873 Cleavage and polyadenylation specificity factor subunit 5 16,21Pc_7453 Flotillin domain-containing protein 16,19Pc_6815 Glycosyltransferase family 22 protein 16,19Pc_8916 Chromo domain 16,15Pc_6233 Hypothetical protein aor_1_48054 16,15Pc_10819 40s ribosomal protein s13 16,15Pc_1827 Rieske 2fe-2s family 16,15Pc_12098 --- n/a --- 16,15Pc_7564 Fatty acid 16,12Pc_9198 Carboxy- -muconate cyclase 16,11Pc_8249 Dna-binding protein 16,11Pc_5418 Hypothetical protein mac_01994 16,09Pc_10247 Alpha-amylase a type-3 precursor 16,08Pc_146 Wd40 domain-containing protein 16,07Pc_783 Tpr repeat-containing protein 16,06Pc_9542 C-4 sterol methyl oxidase 16,05Pc_1380 Short-chain alcohol protein 16,01Pc_10575 Acetyl- acetyltransferase 16,00Pc_11479 --- n/a --- 15,98Pc_5684 Hypothetical protein maa_07116 15,97Pc_7582 Family protein 15,94Pc_8383 Dihydroorotate dehydrogenase a 15,94Pc_8710 Cupin family protein 15,94

Pc_8617 Cytochrome c oxidase biogenesis protein 15,94Pc_921 Tetratricopeptide repeat domain protein 15,91Pc_2270 Protein 15,90Pc_9028 Cell wall glycosyl hydrolase 15,90Pc_7338 Fungal specific transcription factor domain-containing protein 15,89Pc_1570 Sentrin-specific protease 15,89Pc_4640 Integral membrane protein 15,87Pc_7649 Fad binding protein 15,86Pc_10339 Aldo-keto reductase 15,84Pc_10841 37s ribosomal protein s5 15,83Pc_8217 Dnaj domain containing protein 15,81Pc_11537 --- n/a --- 15,81Pc_5859 Hypothetical protein maa_04130 15,80Pc_8901 Cia30 family protein 15,80Pc_7006 Glycoside hydrolase 15,79Pc_9060 Cell division control protein 54 15,77Pc_8723 Cullulin 3 15,77Pc_7224 Gcn5-related n-acetyltransferase 15,74Pc_10012 Ankyrin repeat protein 15,74Pc_12077 --- n/a --- 15,74Pc_9033 Cell wall glucanosyltransferase mwg1 15,74Pc_9565 Bys1 family protein 15,74Pc_6371 Histone-fold domain containing protein 15,71Pc_8858 Coatomer gamma-2 subunit 15,70Pc_10512 Actin-like protein 2 15,70Pc_6736 Gnat family 15,68Pc_6617 Guanylate kinase 15,66Pc_4452 Kinesin light chain 15,63Pc_8121 Duf1275 domain protein 15,62Pc_1643 Sam and ph domain-containing protein 15,62Pc_1193 Spherulin-1b precursor 15,60Pc_895 Thioesterase family protein 15,60Pc_8314 Dna mismatch repair protein pms1 15,60Pc_8737 Cross-pathway control 1 15,60Pc_4863 Hypothetical protein triatdraft_313935 15,57Pc_8214 Dnaj domain protein cwf23 15,57Pc_909 Thermotolerance protein 15,56Pc_6626 Guanine nucleotide-binding protein alpha-2 subunit 15,56Pc_10915 3 exoribonuclease 15,54Pc_6278 Hydroxyacylglutathione hydrolase 15,54Pc_6043 Hypothetical protein maa_01040 15,52Pc_9140 Casein kinase ii 15,51Pc_9213 Carbohydrate esterase family 9 protein 15,51Pc_10765 54s ribosomal protein l7 15,47Pc_4261 Major facilitator superfamily 15,47Pc_7110 Glutamyl-trna a subunit 15,46Pc_6806 Glycosyltransferase family 31 protein 15,46Pc_4406 L-fucose permease 15,46Pc_3416 Nadph-cytochrome p450 reductase 15,44Pc_1129 Stomatin family protein 15,42Pc_3737 Mitochondrial inner membrane protein 15,42

Pc_934 Telomere-associated recq-like helicase 15,42Pc_4107 Membrane protein 15,41Pc_10597 Acetamidase regulatory protein 15,39Pc_3158 O-sialoglycoprotein endopeptidase 15,39Pc_8907 Chromosome segregation protein 15,36Pc_844 Tldc domain containing protein 2 15,34Pc_2175 Protein kinase-like domain 15,34Pc_3333 Nitrilase and fragile histidine triad fusion protein hit 15,34Pc_7748 Extracellular sialidase neuraminidase 15,34Pc_892 Thioesterase superfamily protein 15,34Pc_1585 Secretion pathway protein sls2 rcy1 15,34Pc_1471 Serine threonine-protein phosphatase pp2a catalytic subunit 15,34Pc_4400 L-lysine - 15,31Pc_2869 Pfs domain protein 15,31Pc_1722 Rnp domain protein 15,30Pc_2154 Protein pfs2 15,27Pc_452 Ubiquitin family protein 15,26Pc_9284 Ca2+ h+-exchanging protein 15,25Pc_11987 --- n/a --- 15,25Pc_9296 C6 zinc finger domain-containing protein 15,24Pc_554 Trna-splicing endonuclease subunit sen2 15,24Pc_1218 Sodium hydrogen exchanger 3 15,23Pc_5355 Hypothetical protein mac_03107 15,22Pc_5212 Hypothetical protein mac_05599 15,21Pc_6830 Glycosyltransferase family 1 protein 15,20Pc_10918 3 -5 exoribonuclease csl4 15,18Pc_3645 Mrna splicing factor rna helicase 15,16Pc_7493 Flap structure-specific endonuclease 15,16Pc_11520 --- n/a --- 15,16Pc_9093 Ccr4-not transcription complex 15,16Pc_10106 Amp-binding domain 15,13Pc_1941 Response regulator receiver rim15p 15,10Pc_8593 Cytochrome p450 15,08Pc_11777 --- n/a --- 15,06Pc_1619 Scytalone dehydratase 15,06Pc_10851 30s ribosomal subunit 15,06Pc_928 Monooxygenase fad-binding protein 15,04Pc_10559 Acetylornithine deacetylase 15,04Pc_3536 Nacht and ankyrin domain protein 15,04Pc_2560 Polysaccharide lyase family 7 protein 15,03Pc_8338 Dna damage-binding protein 1 15,02Pc_7605 Family c-likeg-protein-coupled receptor 15,02Pc_10572 Acetyl- carboxylase 15,02Pc_4279 M protein repeat protein 15,01Pc_5543 Hypothetical protein maa_10535 15,00Pc_4078 Metallo-beta-lactamase superfamily protein 15,00Pc_1606 Secreted aspartic proteinase 14,99Pc_6359 Hit finger domain 14,97Pc_9917 Arca-like protein 14,97Pc_10788 5 3 -nucleotidase family protein 14,97Pc_7273 G-protein coupled receptor 14,97

Pc_1724 Rnase z 14,97Pc_8753 Cpr1p 14,97Pc_7339 Fungal specific transcription factor domain-containing protein 14,95Pc_8510 Cytoskeleton assembly control protein sla1 14,95Pc_8453 Defects in morphology protein 1 14,94Pc_8551 Cytochrome p450 52a11 14,91Pc_10562 Acetylornithine aminotransferase 14,90Pc_10410 Agmatine deiminase 14,89Pc_7592 Family protein 14,88Pc_3352 Nicotinic acid plasma membrane transporter 14,85Pc_5443 Hypothetical protein mac_01616 14,83Pc_2906 Peroxin-3 family protein 14,83Pc_10639 Abc transporter 14,83Pc_9642 Beta-lactamase family protein 14,83Pc_8312 Dna polymerase 14,81Pc_1199 Sorting nexin-41 14,80Pc_1266 U3 small nucleolar rna-associated protein 14,79Pc_5926 Hypothetical protein maa_03049 14,78Pc_2784 Phosphatidylinositol 3-kinase 3 14,77Pc_5190 Hypothetical protein mac_05963 14,75Pc_6020 Hypothetical protein maa_01427 14,75Pc_4497 Karyopherin kap123 14,75Pc_4159 Map kinase kinase kinase 14,75Pc_1551 Serine esterase family protein 14,74Pc_1290 Sin3-associated polypeptide sap18 14,73Pc_8813 Membrane fusion mating protein fig1 14,73Pc_906 Thiamine biosynthetic bifunctional 14,73Pc_531 Tumor suppressor candidate 4 14,72Pc_7508 Fha domain containing protein 14,71Pc_11831 --- n/a --- 14,70Pc_2587 Polyketide synthase 14,69Pc_8281 Dna repair protein rad14 14,68Pc_4029 Methylenetetrahydrofolate reductase 14,68Pc_8804 Conserved hypothetical protein 14,65Pc_7627 Fad dependent oxidoreductase superfamily 14,65Pc_1111 Minor extracellular protease vpr 14,63Pc_5878 Hypothetical protein maa_03963 14,61Pc_1713 Rrna methylase 14,61Pc_11297 Hypothetical protein mac_01836 14,61Pc_4582 Integral membrane protein 14,61Pc_5445 Hypothetical protein mac_01591 14,61Pc_8448 Dehydrogenase reductase sdr family member 8 14,61Pc_2835 Phd-finger domain-containing protein 14,59Pc_139 White collar 1 14,58Pc_4145 Mboat family protein 14,58Pc_2506 Pre-mrna splicing factor prp46 14,58Pc_8948 Choline ethanolamine 14,58Pc_3805 Mitochondrial aaa 14,57Pc_6549 Heme steroid binding domain protein 14,56Pc_10356 Aldehyde dehydrogenase 14,55Pc_6814 Glycosyltransferase family 22 protein 14,55

Pc_10172 Amino acid 14,54Pc_3578 Mynd finger family protein 14,54Pc_3270 Nuc-1 negative regulatory protein preg 14,54Pc_458 Ubiquitin conjugating 14,53Pc_8020 Duf862-domain-containing protein 14,52Pc_1030 Sulfate permease 14,51Pc_472 Ubiquitin carboxyl-terminal hydrolase 14,50Pc_11850 --- n/a --- 14,50Pc_5262 Hypothetical protein mac_04764 14,50Pc_1553 Serine 14,47Pc_6367 Histone-lysine n-methyltransferase 14,47Pc_7813 Eukaryotic translation initiation factor 3 subunit g 14,47Pc_3448 Nadh-ubiquinone oxidoreductase subunit 14,44Pc_8900 Cis-3-chloroacrylic acid 14,44Pc_8734 Ctd kinase subunit gamma 14,44Pc_7282 G-protein beta wd- 40 repeats containing 14,43Pc_1672 S-adenosylmethionine-dependent methyltransferase-like protein 14,42Pc_11010 -like protein 14,42Pc_8503 Cytosolic regulator pianissimo 14,41Pc_5923 Hypothetical protein maa_03094 14,41Pc_7659 Fad binding domain-containing protein 14,40Pc_8555 Cytochrome p450 3a17 14,40Pc_9992 Ankyrin repeat-containing 14,39Pc_8586 Cytochrome p450 14,39Pc_5747 Hypothetical protein maa_05928 14,37Pc_12119 --- n/a --- 14,36Pc_10282 Alpha beta hydrolase fold domain containing protein 14,36Pc_4992 Hypothetical protein mac_09798 14,34Pc_7931 Endo- -beta- 14,34Pc_2079 Px domain-containing protein 14,32Pc_7321 Fungal transcriptional regulatory protein 14,32Pc_1788 Rna binding effector protein 14,32Pc_7267 G2 mitotic-specific cyclin 14,32Pc_8831 Conserved fungal protein 14,30Pc_3404 Nb-arc and ankyrin domain protein 14,29Pc_3798 Mitochondrial carrier 14,27Pc_8156 Domain-containing protein 14,27Pc_6740 Gnat family 14,27Pc_7568 Farnesyl pyrophosphate synthetase 14,27Pc_11131 Protein 14,27Pc_2982 Pentatricopeptide repeat protein 14,25Pc_9075 Cell cycle inhibitor 14,23Pc_1852 Ribosomal recycling factor 14,22Pc_9092 Ccr4-not transcription complex subunit 14,21Pc_10499 Acyl binding family protein 14,19Pc_6063 Hypothetical protein maa_00565 14,18Pc_5869 Hypothetical protein maa_04047 14,18Pc_3267 Nuclear condensin complex subunit 14,18Pc_1040 Sulfatase domain protein 14,18Pc_1768 Rna polymerase i-specific transcription initiation factor rrn6-like protein 14,17Pc_5963 Hypothetical protein maa_02472 14,17

Pc_1849 Ribosomal rna-processing protein 12 14,17Pc_4946 Hypothetical protein nechadraft_77412 14,16Pc_5411 Hypothetical protein mac_02095 14,16Pc_5146 Hypothetical protein mac_06649 14,16Pc_6786 Glycosyltransferase family 4 protein 14,15Pc_7496 Fk506-binding protein 2 precursor 14,13Pc_2322 Protein 14,11Pc_1194 Spherulin-1b precursor 14,11Pc_5188 Hypothetical protein mac_05965 14,10Pc_9204 Carbon-nitrogen family protein 14,10Pc_4419 L-aminoadipate-semialdehyde dehydrogenase large subunit 14,09Pc_4681 Inositol phospholipid synthesis protein scs3p 14,09Pc_10613 Abc1 domain protein 14,08Pc_7833 Eukaryotic peptide chain release factor subunit 1 14,08Pc_6252 Hypothetical protein an5419.2 14,06Pc_1898 Riboflavin aldehyde-forming enzyme 14,06Pc_3239 Nuclear protein involved in pre-rrna 14,04Pc_8270 Dna replication atp-dependent helicase dna2 14,03Pc_3635 Mt-a70 family 14,03Pc_4103 Membrane transporter 14,03Pc_7157 Glucose oxidase 14,02Pc_3060 P-type calcium atpase 14,00Pc_10902 3-dehydroshikimate dehydratase 13,99Pc_10942 26s proteasome non-atpase regulatory subunit 12 13,98Pc_734 Brf1-like tbp-binding domain-containing protein 13,97Pc_2635 Plasma membrane 13,95Pc_4654 Integral membrane mpv17 pmp22 13,95Pc_4585 Integral membrane protein 13,95Pc_7926 Endo- -beta-xylanase precursor 13,95Pc_280 Vacuolar protease a 13,95Pc_4480 Kh domain-containing protein 13,95Pc_7511 Ff domain protein 13,93Pc_4471 Kinase activator 13,92Pc_4986 Hypothetical protein mgg_13691 13,92Pc_3717 Mitochondrial protein 13,92Pc_6949 Glycoside hydrolase family 3 protein 13,92Pc_2801 Phosphate transporter 13,91Pc_4965 Hypothetical protein nechadraft_33068 13,90Pc_5205 Hypothetical protein mac_05729 13,90Pc_8636 Cytidine deoxycytidylate deaminase family protein 13,89Pc_6472 Hexokinase 13,86Pc_10476 Acyl- synthetases amp-acid ligases ii 13,85Pc_7958 Eif4-gamma eif5 eif2-epsilon 13,85Pc_10934 26s proteasome regulatory subunit rpn1 13,84Pc_9726 Atpase family protein 13,83Pc_11498 --- n/a --- 13,82Pc_9743 Atp-dependent rna helicase eif4a 13,82Pc_3514 Nad binding rossmann fold 13,79Pc_967 Methyltransferase domain-containing protein 13,79Pc_2084 Purine-cytosine permease fcy22 13,79Pc_11236 Hypothetical protein mycth_2310402 13,79

Pc_9675 Beta- 13,76Pc_8509 N-acetyltransferase b complex non catalytic subunit 13,75Pc_947 Tbc domain-containing protein 13,75Pc_3996 Mevalonate kinase 13,75Pc_3408 Nape-hydrolyzing phospholipase d 13,74Pc_7245 Gamma-glutamyl phosphate reductase 13,73Pc_2338 Protein 13,73Pc_3633 Mtdna inheritance protein 13,72Pc_7897 Enoyl- hydratase 13,72Pc_9715 Autophagy protein atg13 13,71Pc_5622 Hypothetical protein maa_08720 13,71Pc_420 Ubiquitin-like activating enzyme 13,71Pc_4892 Hypothetical protein thite_2039245 13,70Pc_8140 Dsba-like thioredoxin domain protein 13,70Pc_8142 Dsba oxidoreductase 13,70Pc_612 Trapp complex protein trs85 13,68Pc_5039 Hypothetical protein mac_08797 13,66Pc_9588 Breast cancer suppressor protein brct 13,65Pc_1736 Rna-3 -phosphate cyclase family protein 13,64Pc_2075 Pyrazinamidase nicotinamidase 13,64Pc_3668 Monocarboxylate permease-like protein 13,64Pc_319 Uroporphyrinogen-iii synthase 13,64Pc_4054 Metalloprotease atp23 13,64Pc_3828 Microsomal signal peptidase subunit 13,64Pc_1325 Ferri-bacillibactin esterase 13,64Pc_9718 Autophagy protein 13,64Pc_2716 Phospholipid-translocating p-type atpase 13,62Pc_5919 Hypothetical protein maa_03156 13,61Pc_5101 Hypothetical protein mac_07312 13,59Pc_218 Vitamin h 13,58Pc_1484 Serine threonine-protein kinase sgk2 13,56Pc_10554 Acetyltransferase 13,56Pc_4376 Las seventeen-binding protein 13,56Pc_6870 Glycoside hydrolase family 81 protein 13,56Pc_4314 Long-chain fatty acid 13,55Pc_7200 General amino-acid permease gap1 13,55Pc_4235 Major facilitator superfamily transporter 13,54Pc_8888 Class e vacuolar protein-sorting machinery protein hse1 13,53Pc_2750 Phosphoglycerate mutase family protein 13,53Pc_4165 Mannose-6-phosphate isomerase 13,51Pc_9045 Cell surface protein 13,51Pc_2721 Phospholipase d1 13,50Pc_488 Uba domain-containing protein ucp14 13,49Pc_956 Tat pathway signal sequence 13,49Pc_8933 Choline-sulfatase 13,49Pc_11099 Transcription factor 13,49Pc_8298 Dna primase large subunit 13,48Pc_1076 Succinyl- synthetase beta chain 13,47Pc_4548 Iron sulfur assembly protein 1 13,46Pc_8122 Duf1264 domain protein 13,46Pc_3796 Mitochondrial carrier protein 13,46

Pc_4417 L-ascorbate oxidase 13,46Pc_8542 Cytochrome p450 alkane 13,46Pc_5650 Hypothetical protein maa_07820 13,45Pc_9605 Bleomycin hydrolase 13,45Pc_285 Vacuolar iron transporter ccc1 13,44Pc_7361 Fungal specific transcription 13,44Pc_5673 Hypothetical protein maa_07388 13,44Pc_10807 40s ribosomal protein s24 13,44Pc_8239 Dna-directed rna polymerase i subunit rpa1 13,43Pc_1565 Ser thr protein phosphatase 13,43Pc_2930 Peptidyl-prolyl cis-trans isomerase 13,42Pc_10438 Adhesin protein mad1 13,41Pc_9181 Carboxylesterase family protein 13,41Pc_3935 Mfs monosaccharide 13,40Pc_7459 Flocculation suppression protein 13,39Pc_203 Von willebrand and ring finger domain containing protein 13,38Pc_810 Tpa: zn 2cys6 transcription factor 13,37Pc_1257 Small s protein 13,34Pc_2082 Pwi domain mrna processing 13,34Pc_6039 Hypothetical protein maa_01122 13,34Pc_11305 Hypothetical protein maa_10186 13,34Pc_8385 Dihydroorotase 13,34Pc_3806 Mitochondrial 54s ribosomal protein mrpl51 13,34Pc_162 Wd repeat-containing protein 13,32Pc_10446 Adenylate cyclase 13,31Pc_4623 Integral membrane protein 13,31Pc_3142 Oligopeptide transporter 13,30Pc_10938 26s proteasome non-atpase regulatory subunit 9 13,29Pc_8752 Cra-b-like protein 13,29Pc_2492 Pre-mrna-splicing factor cwc15 13,29Pc_1758 Rna polymerase ii transcription factor b subunit 1 13,28Pc_5316 Hypothetical protein mac_03771 13,28Pc_8757 Cox1 assembly protein 13,27Pc_6305 Hsp70 family chaperone 13,27Pc_241 Vegetative cell wall protein gp1 13,25Pc_9593 Branchpoint-bridging protein 13,25Pc_4410 L-ascorbic acid binding protein 13,23Pc_8947 Choline kinase 13,22Pc_7246 Gamma-butyrobetaine dioxygenase 13,21Pc_11811 --- n/a --- 13,20Pc_10951 20s cyclosome subunit (apc1 ) 13,19Pc_1677 S-adenosylmethionine decarboxylase proenzyme 13,19Pc_6236 Hypothetical protein aor_1_1484164 13,17Pc_6044 Hypothetical protein maa_00980 13,15Pc_4929 Hypothetical protein nfia_002560 13,15Pc_4953 Hypothetical protein nechadraft_54681 13,15Pc_4768 Hypothetical protein vdag_05112 13,15Pc_564 Trna pseudouridine synthase 13,15Pc_386 Umta methyltransferase family protein 13,14Pc_3776 Mitochondrial cytochrome 13,14Pc_9067 Cell division control protein 13,12

Pc_2310 Protein 13,12Pc_3583 Myb-like dna-binding domain protein 13,11Pc_99 Xylosidase arabinosidase 13,10Pc_10265 Alpha beta-hydrolase 13,10Pc_1947 Replication factor c protein 13,07Pc_4788 Hypothetical protein trividraft_63893 13,06Pc_11176 Nacht and wd domain protein 13,06Pc_8406 Dienelactone hydrolase family protein 13,06Pc_815 Tpa: patatin-like serine (afu_orthologue afua_8g06310) 13,03Pc_7795 Exocyst complex component sec10 13,03Pc_10240 Alpha-glucosidase 13,03Pc_10919 5 exoribonuclease 13,01Pc_4044 Methionine permease 12,99Pc_6924 Glycoside hydrolase family 47 protein 12,98Pc_1291 Sin3 complex subunit 12,96Pc_6551 Heme peroxidase 12,95Pc_10099 Anaphase-promoting complex subunit 8 12,94Pc_10064 Ankyrin repeat domain-containing protein 28 12,94Pc_5010 Hypothetical protein mac_09407 12,93Pc_4570 Interferon-induced gtp-binding protein mx2 12,93Pc_7131 Glutamate carboxypeptidase 12,93Pc_10956 2-oxoisovalerate dehydrogenase alpha subunit 12,92Pc_11319 Hypothetical protein maa_07895 12,92Pc_8019 Duf866 domain protein 12,92Pc_1141 Sterigmatocystin 8-o-methyltransferase 12,91Pc_4636 Integral membrane protein 12,88Pc_1357 Short-chain dehydrogenase reductase family 12,86Pc_3594 Myb and hsa domain protein 12,86Pc_1646 Salicylate hydroxylase (salicylate 1-monooxygenase) 12,85Pc_8348 Dj-1 family protein 12,84Pc_9692 Bcp1_gibze ame: full=protein bcp1 12,83Pc_10936 26s proteasome regulatory subunit 12,83Pc_3817 Mip transporter 12,83Pc_2692 Phosphoserine aminotransferase 12,82Pc_4365 Lectin family integral membrane 12,82Pc_2681 Phosphotransferase enzyme family protein 12,82Pc_3161 O-methyltransferase family protein 12,79Pc_9174 Carboxymuconolactone decarboxylase 12,79Pc_9038 Cell wall biogenesis protein phosphatase 12,78Pc_10527 Aconitate hydratase 12,77Pc_7719 F-box domain-containing protein 12,77Pc_5022 Hypothetical protein mac_09104 12,75Pc_3548 N-terminal fungal transcription regulatory domain-containing protein 12,75Pc_344 Uracil permease 12,72Pc_631 Transmembrane protein pft27 12,72Pc_2717 Phospholipid-binding protein 12,70Pc_11116 Ring finger domain protein 12,70Pc_447 Ubiquitin interaction domain-containing protein 12,69Pc_282 Zip zinc transporter 12,69Pc_2015 Radh flavin-dependent halogenase 12,68Pc_9185 Carboxylesterase family protein 12,67

Pc_6451 High affinity nickel transport protein nic1 12,66Pc_3769 Mitochondrial division protein 1 12,63Pc_6569 Heat shock transcription factor 12,61Pc_9446 C6 transcription 12,60Pc_3987 Mfs 12,58Pc_10379 Alcohol dehydrogenase 12,57Pc_8181 Domain-containing protein 12,56Pc_6192 Hypothetical protein ch063_05422 12,56Pc_8635 Cytochrome 12,55Pc_10489 Acyl- dehydrogenase 12,55Pc_6646 Gtpase activating protein 12,55Pc_10110 Amp dependent ligase 12,55Pc_1504 Serine threonine-protein kinase cot-1 12,55Pc_9483 C6 finger domain 12,53Pc_3761 Mitochondrial fusion protein 12,53Pc_8447 Delta -sterol reductase 12,53Pc_12081 --- n/a --- 12,53Pc_1072 Sucrose-6-phosphate hydrolase 12,51Pc_5116 Hypothetical protein mac_07150 12,50Pc_8219 Dna-repair protein rad13 12,49Pc_1538 Serine threonine protein 12,49Pc_10503 Activating transcription factor 7a 12,48Pc_1752 Rna polymerase iii subunit rpc82 12,46Pc_11301 Hypothetical protein mac_00149 12,44Pc_9265 Calcium calmodulin-dependent protein kinase 12,43Pc_11379 Hypothetical protein foxb_14947 12,43Pc_10515 Actin-binding protein 12,43Pc_5538 Hypothetical protein mac_00093 12,42Pc_6164 Hypothetical protein fg08204.1 12,42Pc_2326 Protein 12,41Pc_4987 Hypothetical protein mgg_09969 12,40Pc_5307 Hypothetical protein mac_03925 12,38Pc_5110 Hypothetical protein mac_07200 12,37Pc_2968 Peptidase caspase catalytic subunit p20 12,35Pc_7458 Floculation protein flo1 12,35Pc_1190 Sphingolipid long chain base-responsive protein lsp1 12,35Pc_11848 --- n/a --- 12,34Pc_7874 Eps15-like protein pan1p 12,34Pc_2468 Predicted protein 12,34Pc_2273 Protein 12,34Pc_6187 Hypothetical protein ch063_11126 12,33Pc_6287 Hydrogenase maturation factor hoxx 12,33Pc_8832 Conserved fungal protein 12,31Pc_440 Ubiquitin-conjugating enzyme 12,30Pc_9324 C6 zinc finger domain protein 12,30Pc_9495 C2h2 type zinc finger domain protein 12,28Pc_283 Vacuolar membrane protein 12,28Pc_10199 Amidase, putative 12,28Pc_11350 Hypothetical protein maa_03289 12,28Pc_3345 Nitrate assimilation regulatory protein nira 12,28Pc_11959 --- n/a --- 12,28

Pc_391 Udp-n-acetylglucosamine pyrophosphorylase 12,25Pc_11142 Protein 12,24Pc_10677 A chain crystal structure of xylanase from trichoderma longibrachiatum 12,23Pc_1449 Set domain-containing protein 12,23Pc_2860 Pfs domain-containing protein 12,22Pc_3880 Mfs transporter 12,22Pc_2808 Pheromone-regulated membrane protein 12,21Pc_17 Zinc-finger transcription factor 12,21Pc_3719 Mitochondrial presequence protease 12,21Pc_6769 Glycosyltransferase family 90 protein 12,21Pc_11727 --- n/a --- 12,20Pc_7850 Esterase 12,19Pc_185 Set1 complex component swd1 12,18Pc_7304 Fungal transcriptional regulatory-like protein 12,18Pc_6382 Histone h1-binding protein 12,18Pc_4571 Interferon-induced gtp-binding protein mx 12,18Pc_5740 Hypothetical protein maa_06065 12,17Pc_2695 Phosphorus acquisition-controlling protein 12,15Pc_11427 Geranylgeranyl pyrophosphate synthetase 12,15Pc_7389 Fungal hydrophobin 12,15Pc_5907 Hypothetical protein maa_03419 12,15Pc_6377 Histone h3 12,15Pc_7993 Dynein light chain 12,15Pc_7937 Elongator complex protein 12,13Pc_7628 Fad dependent oxidoreductase superfamily 12,12Pc_11451 Cell wall protein 12,11Pc_2937 Peptide transporter 12,11Pc_3681 Molybdenum cofactor biosynthesis protein 1 b 12,11Pc_7956 Electron transfer flavoprotein alpha-subunit 12,10Pc_171 Wd repeat protein 12,09Pc_354 Upf0183 domain-containing protein 12,08Pc_952 Tata binding protein 12,08Pc_3900 Mfs multidrug transporter 12,06Pc_9763 Atp-dependent protease la 12,06Pc_9946 Annexin xiv 12,06Pc_11875 --- n/a --- 12,04Pc_4743 Idi-2 precursor 12,04Pc_9118 Cation channel family protein 12,04Pc_7114 Glutamine-dependent nad(+) synthetase 12,04Pc_1440 Severin kinase 12,04Pc_6947 Glycoside hydrolase family 3 protein 12,02Pc_2335 Protein 12,02Pc_10236 Alpha-glucuronidase 12,00Pc_11335 Hypothetical protein maa_05465 11,99Pc_6110 Hypothetical protein foxb_15540 11,96Pc_8403 Dienelactone hydrolase family protein 11,96Pc_2760 Phosphoglucomutase 2 11,94Pc_2822 Phenol 2-monooxygenase 11,93Pc_5755 Hypothetical protein maa_05836 11,92Pc_5448 Hypothetical protein mac_01549 11,92Pc_981 T-complex protein 1 subunit alpha 11,91

Pc_11169 Outer membrane autotransporter barrel protein 11,90Pc_7586 Family protein 11,90Pc_9514 C2h2 finger domain-containing protein 11,90Pc_3765 Mitochondrial escape protein 2 11,90Pc_9781 Atp-binding cassette transporter abc1 11,89Pc_9931 Ap-2 adaptor complex subunit 11,89Pc_471 Ubiquitin carboxyl-terminal hydrolase 11,88Pc_4801 Hypothetical protein trividraft_36613 11,86Pc_5441 Hypothetical protein mac_01634 11,85Pc_493 U4 u6 small nuclear ribonucleoprotein prp4 11,83Pc_8609 Cytochrome c peroxidase 11,80Pc_7221 Gcn5-related n-acetyltransferase 11,80Pc_5746 Hypothetical protein maa_05953 11,80Pc_8257 Dna replication licensing factor mcm3 11,79Pc_11024 -dimethylglycine oxidase 11,79Pc_530 Twinfilin-1 11,77Pc_1246 Snare complex subunit 11,77Pc_708 Transcriptional activator 11,77Pc_1338 Short-chain dehydrogenase reductase sdr 11,76Pc_2487 Pre-mrna-splicing factor rse-1 11,75Pc_1796 Rli and duf367 domain protein 11,75Pc_3310 Non-hemolytic phospholipase c 11,75Pc_7623 Fad linked oxidase 11,74Pc_10477 Acyl- synthetase-like protein 11,74Pc_10760 6-phosphofructokinase 11,73Pc_3307 Non-ribosomal peptide synthetase 11,73Pc_11649 --- n/a --- 11,71Pc_8134 Dual specificity phosphatase catalytic domain protein 11,70Pc_163 Wd repeat-containing protein 11,70Pc_2046 Pyruvate dehydrogenase protein x component 11,69Pc_1641 Sam dependent 11,68Pc_2469 Predicted protein 11,68Pc_11054 --- n/a --- 11,67Pc_8897 Citrate synthase 11,66Pc_519 Tyrosine-protein phosphatase cdc14 11,65Pc_8273 Dna repair protein rad57 11,65Pc_11337 Hypothetical protein maa_05120 11,65Pc_2081 Pwwp domain-containing protein 11,65Pc_2714 Phospholipid-translocating p-type atpase domain-containing protein 11,63Pc_6886 Glycoside hydrolase family 76 protein 11,63Pc_11151 Predicted protein 11,61Pc_11795 --- n/a --- 11,58Pc_6837 Glycosyl transferase 11,58Pc_8264 Dna replication factor a subunit ssb3 11,58Pc_6555 Helix-loop-helix dna-binding domain-containing protein 11,58Pc_5303 Hypothetical protein mac_03965 11,58Pc_7773 Extracellular dioxygenase 11,58Pc_2242 Protein bfr2 11,58Pc_7408 Fumarate reductase 11,58Pc_11089 Uncharacterized protein cpur_03592 11,55Pc_6491 Heterokaryon incompatibility protein 11,55

Pc_9999 Ankyrin repeat-containing 11,54Pc_2215 Protein kinase 11,53Pc_9951 Ankyrin unc44 11,52Pc_9570 Bud site selection protein 11,50Pc_3981 Mfs allantoate 11,49Pc_6470 Hexokinase-1 11,49Pc_7113 Glutaminyl cyclase 11,49Pc_7160 Glucose galactose transporter 11,48Pc_1248 Smr domain-containing protein 11,47Pc_797 Tpr domain protein 11,46Pc_2325 Protein 11,45Pc_8207 Dock180 protein 11,45Pc_766 Transcription factor 11,45Pc_10506 Activating transcription factor 7a 11,44Pc_8632 Cytochrome b2 11,41Pc_1784 Rna binding protein 11,41Pc_7590 Family protein 11,40Pc_1671 S-adenosylmethionine-dependent methyltransferase-like protein 11,40Pc_2821 Phenol 2-monooxygenase 11,37Pc_11019 -like family protein 11,37Pc_11158 Phosphotransferase enzyme family protein 11,37Pc_9687 Benzoate 4-monooxygenase cytochrome 11,37Pc_2138 Protein pyrabcn 11,37Pc_5221 Hypothetical protein mac_05425 11,37Pc_2062 Pyridoxamine phosphate oxidase family protein 11,37Pc_3121 Opt family small oligopeptide transporter 11,35Pc_1148 Srebp cleavage activating protein 11,35Pc_2392 Prolyl 4-hydroxylase 11,34Pc_8231 Dna-directed rna polymerase iii complex subunit rpc37 11,34Pc_735 Rna polymerase ii transcription factor b subunit 4 11,33Pc_5017 Hypothetical protein mac_09149 11,33Pc_4266 Magnesium transporter alr1 11,33Pc_1499 Serine threonine-protein kinase hal4 11,32Pc_5460 Hypothetical protein mac_01354 11,32Pc_1863 Ribosomal protein l19 11,31Pc_2863 Pfs domain-containing protein 11,30Pc_1095 Probable subtilisin-like serine protease 11,30Pc_10636 Abc transporter 11,30Pc_3615 Multidrug resistance protein 3 (p glycoprotein 3) 11,29Pc_2207 Protein kinase domain protein 11,29Pc_9994 Ankyrin repeat-containing 11,29Pc_4374 Late sexual development protein 11,28Pc_2733 Phospholipase c 11,27Pc_2494 Pre-mrna-splicing factor atp-dependent rna helicase prp22 11,26Pc_639 Transmembrane and coiled-coil domain-containing protein 11,26Pc_5698 Hypothetical protein maa_06902 11,24Pc_9469 C6 finger domain 11,24Pc_10881 3-isopropylmalate dehydratase 11,23Pc_1730 Rna-dependent rna polymerase 11,23Pc_3540 Na k atpase alpha 1 11,20Pc_118 X-pro dipeptidyl-peptidase (s15 family) protein 11,18

Pc_3706 Mitochondrial translation optimization protein 11,18Pc_4447 Kinesin light chain 3 11,16Pc_11855 --- n/a --- 11,16Pc_8808 Conserved hypothetical protein 11,16Pc_7416 Fructosyl amino acid 11,16Pc_4444 Kinesin related protein 1 11,16Pc_5000 Hypothetical protein mac_09640 11,16Pc_2810 Pheromone receptor 2 11,13Pc_3976 Mfs alpha-glucoside transporter 11,12Pc_418 Ubiquitin-like protein 11,11Pc_11644 --- n/a --- 11,11Pc_12082 --- n/a --- 11,11Pc_7540 Fe-containing alcohol 11,09Pc_10361 Aldehyde dehydrogenase 11,09Pc_135 Wound-responsive protein ked 11,09Pc_8674 Cyclin-like protein 11,09Pc_2907 Peroxin 26 11,08Pc_4004 Methyltransferase oms1 11,07Pc_1727 Rnase h domain containing protein 11,06Pc_11222 Hypothetical protein snog_02086 11,06Pc_5647 Hypothetical protein maa_08006 11,05Pc_8756 Coxi translation protein cya5 11,04Pc_3453 Nadh-ubiquinone oxidoreductase kda subunit 11,03Pc_469 Ubiquitin carboxyl-terminal hydrolase 13 11,03Pc_3738 Mitochondrial inner membrane protease subunit 11,03Pc_2915 Periodic tryptophan protein 2 11,01Pc_1343 Short-chain dehydrogenase reductase sdr 11,00Pc_3350 Nima interactive protein 10,99Pc_3324 Nitrogen assimilation transcription factor nira 10,99Pc_4572 Interferon-induced gtp-binding protein mx 10,99Pc_7512 Fes cip4 domain-containing protein 10,99Pc_8522 Cytochrome p450 oxidoreductase 10,99Pc_8841 Complex 1 protein (lyr family) protein 10,96Pc_4741 Idi-3 protein 10,96Pc_2707 Phosphopantothenoylcysteine decarboxylase 10,96Pc_11038 -bisphosphoglycerate-independent phosphoglycerate mutase 10,96Pc_9885 Armadillo repeat protein 10,95Pc_1224 Snornp assembly factor 10,94Pc_1901 Rhoptry protein 10,94Pc_1465 Serine-rich protein 10,93Pc_3426 Nadp:d-xylose dehydrogenase 10,93Pc_9260 Myosin regulatory light chain 1 10,92Pc_1577 Secretory lipase family protein 10,91Pc_4358 Leucine rich repeat domain containing protein 10,91Pc_6487 Heterokaryon incompatibility protein 10,91Pc_11366 Hypothetical protein maa_00120 10,90Pc_289 Vacuolar carboxypeptidase 10,90Pc_7933 Endo alpha- polygalactosaminidase precusor 10,90Pc_9753 Atp-dependent rna helicase dbp4 10,90Pc_1666 Saccharopine dehydrogenase 10,89Pc_11879 --- n/a --- 10,88

Pc_2510 Pre-mrna splicing factor clf1 10,87Pc_5064 Hypothetical protein mac_08107 10,86Pc_3478 Nadh fad-containing subunit 10,85Pc_10322 Alkaline serine protease alp1 10,85Pc_1637 Sant n-cor and tfiiib dna-binding domain-containing protein 10,85Pc_9348 C6 transcription factor 10,83Pc_8116 Duf1295-domain-containing partial 10,83Pc_8100 Duf1713 domain protein 10,83Pc_11978 --- n/a --- 10,82Pc_1367 Short-chain dehydrogenase 10,81Pc_3084 Oxidoreductase domain containing protein 10,81Pc_3943 Mfs monocarboxylate transporter 10,79Pc_9493 C2h2 type zinc finger domain-containing protein 10,79Pc_9120 Cation 10,78Pc_6078 Hypothetical protein maa_00184 10,77Pc_11501 --- n/a --- 10,77Pc_9733 Atp-dependent rrna helicase spb4 10,75Pc_10991 1-phosphatidylinositol-3-phosphate 5-kinase 10,73Pc_9574 Btb poz domain protein 10,73Pc_10671 Aaa family 10,73Pc_2390 Prolyl aminopeptidase (secreted protein) 10,72Pc_7655 Fad binding domain-containing protein 10,71Pc_9136 Casein kinase ii subunit beta-1 10,71Pc_6025 Hypothetical protein maa_01404 10,69Pc_6967 Glycoside hydrolase family 2 protein 10,69Pc_4678 Inositol pyrophosphate synthase 10,68Pc_8398 Dihydrodipicolinate synthetase family protein 10,67Pc_11789 --- n/a --- 10,66Pc_7290 G u mismatch-specific uracil dna glycosylase 10,66Pc_3952 Mfs monocarboxylate 10,65Pc_9131 Catabolite repression protein crec 10,65Pc_2244 Protein arginine n-methyltransferase 1 10,64Pc_711 Sensor of mitochondrial dysfunction 10,63Pc_7116 Glutamine synthetase 10,61Pc_1450 Set domain-containing protein 8 10,61Pc_1526 Serine threonine protein kinase 10,61Pc_660 Translation initiation factor if-2 10,61Pc_9208 Carbohydrate-binding protein 10,60Pc_7642 Fad dependent oxidoreductase 10,58Pc_856 Threonyl-trna synthetase 10,58Pc_10336 Aldo-keto reductase family 1 member e1 10,58Pc_3545 N-terminal fungal transcription regulatory domain-containing protein 10,58Pc_2060 Pyrimidine 5 -nucleotidase 10,58Pc_10138 Amino-acid permease inda1 10,58Pc_7087 Glutathione s- 10,58Pc_3491 Nad transhydrogenase 10,57Pc_2765 Phosphodiesterase alkaline phosphatase d 10,55Pc_4460 Kinesin family protein 10,54Pc_2332 Protein 10,53Pc_9922 Apses transcription factor 10,53Pc_9775 Atp-dependent bile acid permease 10,53

Pc_5704 Hypothetical protein maa_06720 10,52Pc_3561 N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 10,51Pc_8793 Conserved hypothetical protein 10,51Pc_3955 Mfs monocarboxylate 10,49Pc_6445 High-affinity methionine permease 10,49Pc_10988 12-oxophytodienoate reductase 10,48Pc_7324 Fungal transcriptional regulatory protein 10,46Pc_3004 Pathogenicity protein 10,46Pc_2924 Peptidyl-prolyl cis-trans isomerase cyp8 10,46Pc_1176 Spindle-pole body protein 10,45Pc_4329 Lipase 10,45Pc_1403 Short chain dehydrogenase reductase family 10,45Pc_8594 Cytochrome p450 10,44Pc_3525 Nacht domain protein 10,43Pc_10627 Abc transporter 10,42Pc_1702 Rsc complex subunit rsc7 10,40Pc_1549 Serine family amino acid catabolism-related protein 10,37Pc_2676 Phosphotransferase enzyme family protein 10,37Pc_6237 Hypothetical protein aor_1_1228084 10,37Pc_10542 Acid 10,36Pc_8824 Conserved hypothetical protein 10,36Pc_2333 Protein 10,35Pc_11858 --- n/a --- 10,34Pc_6562 Heavy metal translocating p-type atpase 10,34Pc_6910 Glycoside hydrolase family 55 protein 10,34Pc_210 Chloride channel protein 5 10,33Pc_349 Upf0261 domain-containing protein 10,33Pc_2002 Ras gtpase activating protein 10,33Pc_4899 Hypothetical protein snas_0568 10,32Pc_881 Thioredoxin m-type 10,32Pc_9507 C2h2 transcription factor 10,32Pc_4602 Integral membrane protein 10,30Pc_3975 Mfs amine 10,29Pc_3921 Mfs multidrug 10,29Pc_620 Transposase-like protein 10,29Pc_24 Zinc-binding oxidoreductase 10,29Pc_5185 Hypothetical protein mac_06068 10,29Pc_10507 Activating signal cointegrator 1 complex subunit 3 10,28Pc_8986 Cfem domain-containing protein 10,28Pc_2080 Px domain-containing protein 10,28Pc_9967 Ankyrin repeat-containing protein 10,27Pc_2943 Peptidase u61 ld-carboxypeptidase a 10,26Pc_2769 Phospho-2-dehydro-3-deoxyheptonate aldolase 10,25Pc_678 Transferase family protein 10,25Pc_3814 Mis6 domain-containing protein 10,25Pc_411 Ubiquitin related modifier 1 10,23Pc_4712 Indoleamine -dioxygenase pyrrole -dioxygenase 10,23Pc_7077 Glutathione s-transferase 10,23Pc_11591 --- n/a --- 10,23Pc_8800 Conserved hypothetical protein 10,23Pc_3433 Nadp-dependent alcohol dehydrogenase c 10,20

Pc_9858 Arv1-like family protein 10,20Pc_8578 Cytochrome p450 10,19Pc_7091 Glutathione s- 10,19Pc_7645 Fad dependent 10,19Pc_7264 G2-specific protein kinase nim-1 10,19Pc_3703 Mitochondrion protein 10,18Pc_8917 Chromo domain 10,17Pc_10950 20s cyclosome subunit (apc1 ) 10,17Pc_11329 Hypothetical protein maa_06773 10,17Pc_3275 Nrps-like enzyme 10,17Pc_5123 Hypothetical protein mac_07039 10,17Pc_784 Tpr repeat protein 10,16Pc_77 Zinc finger protein 10,15Pc_4181 Maltose permease 10,15Pc_4234 Major facilitator superfamily transporter 10,15Pc_4544 Iron-sulfur cluster assembly accessory protein 10,15Pc_12054 --- n/a --- 10,15Pc_7402 Fumarylacetoacetate hydrolase 10,13Pc_2605 Poly(3-hydroxybutyrate) depolymerase 10,12Pc_5161 Hypothetical protein mac_06372 10,12Pc_8199 Domain and endonuclease exonuclease phosphatase 10,12Pc_11794 --- n/a --- 10,12Pc_7497 Fk506-binding protein 2 10,12Pc_4449 Kinesin light chain 1 10,11Pc_11736 --- n/a --- 10,10Pc_1618 Sda1 domain protein 10,10Pc_8524 Cytochrome p450 oxidoreductase 10,10Pc_1656 Salicylate 1-monooxygenase 10,09Pc_7529 Ferric reductase like transmembrane component 10,08Pc_7061 Glutathione synthetase large chain 10,08Pc_1426 Protein arginine n-methyltransferase 10,07Pc_5176 Hypothetical protein mac_06159 10,07Pc_5942 Hypothetical protein maa_02822 10,06Pc_3298 Non-ribosomal peptide synthetase 10,04Pc_826 Fad nad-p-binding domain-containing protein 10,03Pc_2702 Phosphoribosylaminoimidazole-succinocarboxamide synthase 10,03Pc_4719 Importin-beta domain-containing protein 10,02Pc_10441 Adenylyl cyclase-associated protein 10,02Pc_8776 Cop9 signalosome complex subunit 3 10,02Pc_5160 Hypothetical protein mac_06378 10,02Pc_201 Vps52 sac2 family protein 10,00Pc_4330 Lipase 3 precursor 9,99Pc_9889 Arid bright dna binding domain containing protein 9,98Pc_891 Thioesterase family protein 9,98Pc_9392 C6 transcription 9,98Pc_395 Udp-glucose 4-epimerase 9,98Pc_9630 Beta-tubulin cofactor d 9,96Pc_1454 Set domain containing protein 9,96Pc_5875 Hypothetical protein maa_03994 9,96Pc_61 Zinc finger protein 9,95Pc_2973 Peptidase acyl-coenzyme a:6-aminopenicillanic acid acyl-transferase 9,95

Pc_258 Vacuolar protein sorting-associated protein vps5 9,94Pc_1214 Phosphate-repressible phosphate permease 9,93Pc_2461 Predicted protein 9,93Pc_373 Unnamed protein product 9,93Pc_4496 Kelch domain-containing protein 9,92Pc_9255 Calcium proton exchanger 9,90Pc_6839 Glycosyl transferase 9,90Pc_6732 Gnat family 9,90Pc_6313 Hscarg dehydrogenase 9,90Pc_8295 Dna repair and recombination protein rad54 9,89Pc_4292 Lysine-specific histone demethylase 1 9,88Pc_2155 Protein pbn1 9,88Pc_7641 Fad dependent oxidoreductase 9,88Pc_2143 Protein phosphatase regulatory subunit 9,87Pc_1872 Ribose-phosphate pyrophosphokinase 9,87Pc_11008 -like protein 9,86Pc_3051 P60-like cell-wall peptidase 9,86Pc_7632 Fad dependent oxidoreductase domain containing protein 9,85Pc_2037 Queuine trna-ribosyltransferase 9,85Pc_10394 Alcohol dehydrogenase 9,85Pc_1081 Succinate-semialdehyde dehydrogenase 9,84Pc_5840 Hypothetical protein maa_04375 9,84Pc_4281 Lysyl-trna synthetase 9,84Pc_7329 Fungal transcriptional regulatory protein 9,83Pc_918 Hypothetical protein mac_01158 9,82Pc_9799 Atp synthase beta mitochondrial precursor 9,82Pc_7613 Fad-dependent monooxygenase 9,82Pc_2999 Pbsp domain-containing protein 9,82Pc_7205 General amino acid permease agp3 9,81Pc_5754 Hypothetical protein maa_05843 9,80Pc_7739 F-box domain containing protein 9,80Pc_5373 Hypothetical protein mac_02723 9,80Pc_4947 Hypothetical protein nechadraft_77284 9,79Pc_2228 Protein kinase 9,79Pc_2755 Phosphoglycerate mutase family 9,78Pc_6130 Hypothetical protein foxb_09983 9,78Pc_2829 Phd-finger domain-containing protein 9,78Pc_10602 Acetamidase 9,78Pc_4120 Meiotic recombination protein dmc1 9,77Pc_9058 Cell division gtp binding protein 9,77Pc_769 Transcription factor 9,77Pc_4894 Hypothetical protein terg_03986 9,74Pc_5533 Hypothetical protein mac_00152 9,74Pc_1033 Sulfate adenylyltransferase 9,74Pc_2396 Proline-rich protein 9,73Pc_6117 Hypothetical protein foxb_13700 9,73Pc_10310 Allantoate permease 9,72Pc_9010 Cell wall serine-threonine-rich galactomannoprotein mp1 9,72Pc_8885 Class ii aldolase adducin domain containing protein 9,71Pc_2010 Ran exchange factor prp20 9,70Pc_3919 Mfs multidrug 9,70

Pc_7168 Gluconate 5-dehydrogenase 9,70Pc_9974 Ankyrin repeat-containing 9,69Pc_8719 Cupin domain protein 9,69Pc_8421 Dhh phosphoesterase 9,69Pc_10332 Aldose 1-epimerase family protein 9,68Pc_10052 Ankyrin repeat protein 9,67Pc_7452 Fluconazole resistance protein 9,66Pc_4069 Metallopeptidase 9,66Pc_7790 Exocyst complex protein exo70 9,65Pc_7223 Gcn5-related n-acetyltransferase 9,64Pc_8702 Cutinase transcription factor 1 9,63Pc_8108 Duf1620-domain-containing protein 9,63Pc_9762 Atp-dependent rna helicase 9,63Pc_1328 Siderochrome-iron 9,63Pc_6465 Hexose transporter 9,62Pc_1459 Serum paraoxonase lactonase 3 9,62Pc_9982 Ankyrin repeat-containing 9,62Pc_500 U3 small nucleolar rna associated protein 9,61Pc_8170 Domain-containing protein 9,61Pc_1284 Sister chromatid cohesion protein mis4 9,61Pc_5379 Hypothetical protein mac_02645 9,59Pc_7938 Elongation factor tu gtp binding domain protein 9,58Pc_3887 Mfs sugar 9,57Pc_170 Wd repeat protein 9,57Pc_6996 Glycoside hydrolase family 16 protein 9,57Pc_4639 Integral membrane protein 9,57Pc_1682 Rxt2-like protein 9,57Pc_1846 Ribosome assembly protein 4 9,56Pc_2295 Protein 9,56Pc_1467 Serine threonine-protein phosphatase pp2a catalytic subunit 9,56Pc_6602 Haloacid dehalogenase 9,55Pc_5561 Hypothetical protein maa_09928 9,55Pc_7797 Exo-rhamnogalacturonase b 9,55Pc_1854 Ribosomal protein subunit l37 9,54Pc_3336 Nitrate transporter 9,53Pc_328 Ureidoglycolate hydrolase 9,53Pc_11138 Protein 9,53Pc_1703 Rsc complex subunit rsc1 9,52Pc_1288 Siroheme synthase 9,52Pc_6144 Hypothetical protein foxb_04442 9,52Pc_4786 Hypothetical protein trividraft_66951 9,52Pc_2847 Ph response protein 9,50Pc_1890 Ribonuclease h 9,49Pc_7922 Endonuclease exonuclease phosphatase family protein 9,49Pc_5500 Hypothetical protein mac_00583 9,49Pc_4763 Hypothetical protein 9,48Pc_9434 C6 transcription 9,47Pc_3317 Nlp p60 protein 9,44Pc_7960 Efflux pump antibiotic resistance 9,44Pc_9886 Arm-like repeat-containing protein 9,44Pc_3235 Nuclear protein snf4 9,44

Pc_10455 Adaptin ear-binding coat-associated protein 2 9,44Pc_568 Trna nucleotidyltransferase 9,44Pc_7543 Fatty-acid amide hydrolase 9,44Pc_5677 Hypothetical protein maa_07214 9,44Pc_3622 Multicopper oxidase family protein 9,43Pc_7662 Fad binding domain-containing protein 9,43Pc_4178 Maltose permease 9,42Pc_2981 Pentatricopeptide repeat protein 9,41Pc_2483 Pre-rrna processing protein 9,40Pc_9452 C6 transcription 9,40Pc_4046 Methionine aminopeptidase 9,39Pc_6749 Glyoxalase family protein 9,37Pc_84 Yt521-b-like family protein 9,37Pc_8770 Copi-coated vesicle 9,37Pc_7875 Epoxide hydrolase 9,37Pc_5845 Hypothetical protein maa_04288 9,36Pc_8334 Dna double-strand break repair and vj recombination xrcc4 9,36Pc_12023 --- n/a --- 9,36Pc_378 Uncharacterized serine-rich protein 9,35Pc_313 Vacuolar atp synthase subunit c 9,35Pc_4783 Hypothetical protein trividraft_70692 9,35Pc_4997 Hypothetical protein mac_09716 9,35Pc_266 Vacuolar protein sorting-associated protein 27 9,34Pc_8410 Dicer-like protein 2 9,33Pc_188 G-protein beta wd-40 repeats containing 9,32Pc_3625 Multicopper like protein 9,32Pc_1743 Rna recognition domain-containing protein 9,30Pc_7883 Epoxide 9,30Pc_10717 60s ribosomal protein l32 9,30Pc_4485 Ketose-bisphosphate aldolase class-ii family protein 9,30Pc_7913 Endoribonuclease l-psp 9,30Pc_10035 Ankyrin repeat protein 9,30Pc_9436 C6 transcription 9,30Pc_11951 --- n/a --- 9,30Pc_2477 Pre-rrna-processing protein pno1 9,27Pc_6573 Heat shock protein hsp98 9,27Pc_37 Zip zinc transporter 9,25Pc_5766 Hypothetical protein maa_05643 9,25Pc_5800 Hypothetical protein maa_05094 9,25Pc_9998 Ankyrin repeat-containing 9,25Pc_7442 Folic acid synthesis protein 9,24Pc_9596 Branched-chain-amino-acid aminotransferase 5 9,23Pc_1600 Secreted aspartic proteinase precursor 9,23Pc_11781 --- n/a --- 9,23Pc_3688 Mmc protein 9,23Pc_2955 Peptidase family t4 protein 9,23Pc_1275 Lsm domain-containing protein 9,23Pc_11312 Hypothetical protein maa_09129 9,23Pc_11275 Hypothetical protein mac_04606 9,22Pc_9810 Atp binding 9,21Pc_4113 Meiotically up-regulated protein 9,21

Pc_1180 Spindle pole body component 9,20Pc_2400 Proline racemase 9,20Pc_4179 Maltose permease 9,20Pc_3494 Nad dependent epimerase dehydratase family protein 9,20Pc_5414 Hypothetical protein mac_02059 9,20Pc_3482 Nad-dependent epimerase dehydratase 9,19Pc_2772 Phosphatidylserine decarboxylase proenzyme 1 9,18Pc_3045 Pab1 binding protein 9,17Pc_254 Vacuolar sorting protein 39 domain 1 9,17Pc_5092 Hypothetical protein mac_07515 9,16Pc_6758 Glyoxalase bleomycin resistance protein dioxygenase 9,16Pc_1506 Serine threonine-protein kinase cbk1 9,16Pc_8818 Conserved hypothetical protein 9,16Pc_8845 Coiled-coil domain-containing protein 55 9,16Pc_2874 Pescadillo 9,16Pc_9656 Beta-lactamase 9,14Pc_1231 Snf2 family helicase 9,14Pc_7890 Enoyl- hydratase isomerase family protein 9,13Pc_10555 Acetyltransferase 9,12Pc_3145 Oligopeptide transporter 9,12Pc_524 Tyrosinase 2 9,11Pc_5571 Hypothetical protein maa_09726 9,11Pc_2872 Pex19 protein family 9,11Pc_494 U4 tri-snrnp-associated protein 9,09Pc_2909 Peroxin 20 9,08Pc_10609 Abhydrolase domain-containing protein 9,08Pc_3888 Mfs sugar 9,08Pc_5662 Hypothetical protein maa_07612 9,07Pc_9332 C6 zinc finger domain protein 9,07Pc_8417 Diacylglycerol o-acyltransferase 2b 9,06Pc_4348 Leukotriene a-4 hydrolase 9,06Pc_6436 Histidine acid 9,06Pc_10437 Adhesin protein mad2 9,06Pc_4005 Methyltransferase lae1 9,06Pc_2791 Phosphatidyl inositol 3-kinase 9,05Pc_9203 Carbon-nitrogen hydrolase 9,05Pc_9752 Atp-dependent rna helicase dbp8 9,04Pc_9731 Atp-nad kinase 9,04Pc_4812 Hypothetical protein trividraft_220232 9,03Pc_8315 Dna mismatch repair protein msh6 9,03Pc_7393 Fumarylacetoacetate hydrolase family protein 9,03Pc_8623 Cytochrome c heme lyase 9,03Pc_10246 Alpha-galactosidase 9,01Pc_770 Regulatory protein abaa 9,01Pc_7240 Gamma-tubulin complex component gcp6 9,01Pc_1104 Subtilisin-like protease pr1a 8,99Pc_774 Transcription elongation factor spt6 8,99Pc_1794 Rna 3 -terminal phosphate cyclase 8,98Pc_10831 4-coumarate- ligase 2 8,98Pc_5847 Hypothetical protein maa_04281 8,98Pc_11778 --- n/a --- 8,97

Pc_8044 Duf636 domain protein 8,96Pc_3676 Molybdopterin cofactor 8,95Pc_3221 Nucleolar gtp-binding protein 8,95Pc_78 Zinc carboxypeptidase 8,94Pc_11650 --- n/a --- 8,94Pc_10135 Aminodeoxychorismate lyase 8,93Pc_11385 Hypothetical protein foc4_g10000812 8,90Pc_6379 Histone h2b 8,90Pc_11688 --- n/a --- 8,90Pc_10020 Ankyrin repeat protein 8,90Pc_2767 Phospho-2-dehydro-3-deoxyheptonate aldolase 8,90Pc_11243 Hypothetical protein mac_09759 8,90Pc_9582 Btb domain and ankyrin repeat containing protein 8,88Pc_9589 Breast cancer protein 8,88Pc_7789 Exocyst component sec3 8,88Pc_9336 C6 zinc finger protein 8,87Pc_10292 Alpha beta fold family 8,87Pc_2730 Phospholipase carboxylesterase 8,86Pc_6614 H k atpase alpha 8,86Pc_3627 Muconate cycloisomerase 1 8,85Pc_721 Transcription initiation factor tfiid 127kd subunit 8,85Pc_4336 Lipase 8,85Pc_1879 Ribonucleoside-diphosphate reductase small chain 8,85Pc_970 Tafazzin 8,85Pc_7101 Glutamyl-trna b subunit 8,84Pc_7961 Efflux pump antibiotic resistance 8,83Pc_4010 Methyltransferase domain-containing protein 8,83Pc_659 Translation initiation factor if-3 8,83Pc_4967 Hypothetical protein nechadraft_27635 8,83Pc_11386 Hypothetical protein fg04073.1 8,82Pc_7311 Fungal transcriptional regulatory protein 8,81Pc_10370 Aldehyde 8,80Pc_2654 Phytanoyl- dioxygenase 8,80Pc_11124 Protein kinase-like domain 8,79Pc_7924 Endochitinase 8,79Pc_2541 Potassium sodium efflux p-type atpase 8,78Pc_279 Vacuolar protein 8 8,77Pc_10127 Aminomethyltransferase protein 8,77Pc_7153 Glucose repressible protein grg1 8,77Pc_5807 Hypothetical protein maa_04976 8,77Pc_11977 --- n/a --- 8,77Pc_5532 Hypothetical protein mac_00204 8,75Pc_9760 Atp-dependent rna helicase 8,75Pc_5200 Hypothetical protein mac_05775 8,75Pc_4750 Ibr domain-containing protein 8,74Pc_10540 Acid phosphatase 8,73Pc_6366 Histone-lysine n-methyltransferase 8,73Pc_3634 Mtdna inheritance protein 8,73Pc_2366 Proteasome regulatory non-atpase-like protein 8,73Pc_957 Tat pathway signal sequence 8,73Pc_10263 Alpha- 8,72

Pc_2942 Peptidase u61 ld-carboxypeptidase a 8,72Pc_3368 Neutral protease 8,72Pc_545 Tryptophanyl-trna synthetase 8,72Pc_4218 Major facilitator superfamily transporter 8,72Pc_6413 Histidine kinase hhk5p 8,71Pc_15 Zinc-regulated transporter 1 8,71Pc_3021 Pap2 domain protein 8,69Pc_5769 Hypothetical protein maa_05562 8,69Pc_2556 Polysugar degrading enzyme 8,69Pc_2735 Phospholipase a2 8,68Pc_1597 Secreted lipase 8,68Pc_7440 Folylpolyglutamate synthase 8,67Pc_6105 Hypothetical protein foxb_16773 8,66Pc_7436 Forkhead domain-containing protein 8,66Pc_8489 D-lactate dehydrogenase 2 8,66Pc_2739 Phosphoinositide phosphatase 8,66Pc_8759 Coq5 family 8,64Pc_26 Zinc-binding oxidoreductase 8,64Pc_8342 Dna damage repair protein 8,64Pc_763 -n domain-containing protein 8,64Pc_11921 --- n/a --- 8,64Pc_8779 Conserved serine-threonine rich protein 8,63Pc_6832 Glycosyltransferase (n-glycosyltransferase) (n-glycosyl transferase ngt) 8,62Pc_8424 Developmentally regulated gtp-binding protein 1 8,62Pc_5833 Hypothetical protein maa_04626 8,62Pc_7517 Feruloyl esterase a 8,61Pc_5626 Hypothetical protein maa_08652 8,60Pc_5472 Hypothetical protein mac_01146 8,60Pc_10397 Alanyl-trna synthetase 8,59Pc_6323 Homoserine kinase 8,57Pc_2868 Pfs domain protein 8,57Pc_9315 C6 zinc finger domain protein 8,56Pc_12058 --- n/a --- 8,56Pc_4686 Inositol hexaphosphate kinase kcs1 8,54Pc_3679 Molybdenum cofactor sulfurase 8,52Pc_3946 Mfs monocarboxylate 8,51Pc_913 Tfiiic transcription initiation factor complex subunits tfc3 8,49Pc_3295 Non-ribosomal peptide synthetase 8,49Pc_5989 Hypothetical protein maa_02131 8,49Pc_5184 Hypothetical protein mac_06072 8,49Pc_1741 Rna recognition motif containing protein 8,48Pc_5592 Hypothetical protein maa_09291 8,48Pc_10183 Amidohydrolase family protein 8,47Pc_5402 Hypothetical protein mac_02267 8,47Pc_406 Ubx domain-containing protein 8,47Pc_5948 Hypothetical protein maa_02752 8,47Pc_5891 Hypothetical protein maa_03629 8,47Pc_3936 Mfs monosaccharide 8,47Pc_5906 Hypothetical protein maa_03431 8,47Pc_5735 Hypothetical protein maa_06124 8,45Pc_579 Trna (cytosine-5-)-methyltransferase ncl1 8,45

Pc_11623 --- n/a --- 8,44Pc_8243 Dna-directed rna polymerase 8,43Pc_10656 Abc bile acid transporter 8,43Pc_10914 3 exoribonuclease family protein 8,43Pc_5462 Hypothetical protein mac_01303 8,42Pc_11734 --- n/a --- 8,41Pc_1630 Sarcosine oxidase 8,41Pc_7976 Ef hand family protein 8,41Pc_1287 Sis domain-containing protein 8,39Pc_3375 Neutral alkaline nonlysosomal 8,38Pc_900 Thioesterase domain containing protein 8,37Pc_9536 C2 domain containing protein 8,37Pc_4542 Iron-sulfur clusters transporter atm1 8,37Pc_8532 Cytochrome p450 monooxygenase 8,37Pc_11725 --- n/a --- 8,36Pc_4644 Integral membrane protein 8,36Pc_10129 Aminoglycoside phosphotransferase 8,35Pc_3563 N-acetylglucosamine-6-phosphate deacetylase 8,35Pc_1229 Snf2 family helicase 8,35Pc_109 Xap5 domain-containing protein 8,34Pc_764 Transcription factor 8,33Pc_8691 Cyclase dehydrase family protein 8,33Pc_7074 Glutathione s-transferase 8,33Pc_12034 --- n/a --- 8,33Pc_5793 Hypothetical protein maa_05174 8,33Pc_1293 Transcriptional sir2 family protein 8,32Pc_7169 Glucokinase regulator family 8,32Pc_5967 Hypothetical protein maa_02444 8,32Pc_7656 Fad binding domain-containing protein 8,31Pc_8051 Duf544 domain-containing protein 8,30Pc_8615 Cytochrome c oxidase copper chaperone 8,29Pc_4767 Hypothetical protein vdag_05817 8,29Pc_8037 Duf718 domain protein 8,29Pc_3803 Mitochondrial atp synthase epsilon chain domain-containing protein 8,29Pc_11041 --- n/a --- 8,29Pc_11534 --- n/a --- 8,29Pc_11529 --- n/a --- 8,29Pc_4432 Kow motif containing protein 8,29Pc_2690 Phosphoserine phosphatase 8,29Pc_11357 Hypothetical protein maa_02359 8,29Pc_6501 Heterokaryon incompatibility 8,28Pc_3353 Nicotinate-nucleotide pyrophosphorylase 8,27Pc_9702 Bactericidal permeability-increasing alpha beta domain 8,26Pc_6957 Glycoside hydrolase family 25 protein 8,26Pc_5330 Hypothetical protein mac_03560 8,24Pc_8482 D-xylulose kinase 8,24Pc_1732 Rna-binding protein 8a 8,24Pc_10185 Amidohydrolase family protein 8,24Pc_2766 Phosphoadenosine phosphosulfate reductase 8,24Pc_291 Vacuolar calcium ion transporter 8,23Pc_1127 Streptomycin biosynthesis protein 8,22

Pc_1183 Spindle assembly checkpoint component mad1 8,21Pc_4053 Metalloprotease mep1 8,21Pc_10290 Alpha beta hydrolase 8,19Pc_10130 Aminoglycoside phosphotransferase 8,18Pc_5353 Hypothetical protein mac_03135 8,18Pc_4158 Map kinase kinase kinase 8,18Pc_933 Telomere-binding alpha subunit central domain-containing protein 8,18Pc_3837 Mfs transporter 8,18Pc_11916 --- n/a --- 8,18Pc_66 Zinc finger protein 8,17Pc_352 Upf0187 domain membrane protein 8,16Pc_7711 F-box lrr repeat containing protein 2 8,16Pc_4685 Inositol monophosphatase 8,16Pc_6677 Gpr fun34 family protein 8,15Pc_6231 Hypothetical protein bc1g_06253 8,15Pc_4561 Intradiol partial 8,14Pc_8552 Cytochrome p450 51b 8,14Pc_6029 Hypothetical protein maa_01318 8,13Pc_3674 Monoamine oxidase 8,13Pc_10288 Alpha beta hydrolase 8,13Pc_9782 Atp-binding cassette transporter 8,11Pc_675 Transient receptor potential domain containing protein 8,10Pc_10468 Acyl-protein thioesterase 8,10Pc_3949 Mfs monocarboxylate 8,09Pc_2742 Phosphoinositide 3- 8,09Pc_6953 Glycoside hydrolase family 29 protein 8,09Pc_3994 Mfs 8,09Pc_11888 --- n/a --- 8,08Pc_5680 Hypothetical protein maa_07166 8,08Pc_7727 F-box domain protein 8,08Pc_11168 Pal1-like protein 8,08Pc_9790 Atp synthase subunit 5 8,08Pc_8 Zn 2cys6 transcription factor 8,08Pc_4114 Meiotically up-regulated gene 182 protein 8,08Pc_1861 Ribosomal protein l24e 8,07Pc_4930 Hypothetical protein nfia_000660 8,06Pc_2795 Phosphatidate cytidylyltransferase 8,06Pc_1841 Ribosome biogenesis protein 8,06Pc_11566 --- n/a --- 8,06Pc_9429 C6 transcription 8,05Pc_10177 Amine oxidase 8,05Pc_7702 F420-dependent nadp reductase 8,05Pc_4525 Isocitrate lyase 8,05Pc_3870 Mfs transporter 8,05Pc_10316 Allantoate permease 8,05Pc_8306 Dna polymerase epsilon 8,04Pc_670 Translation elongation factor eef-1b gamma 8,04Pc_3424 Nadph dehydrogenase 8,02Pc_5889 Hypothetical protein maa_03699 8,02Pc_1790 Rna binding domain-containing protein 8,02Pc_5508 Hypothetical protein mac_00484 8,02

Pc_10911 3-beta hydroxysteroid dehydrogenase isomerase family 8,01Pc_11671 --- n/a --- 8,01Pc_6587 Heat repeat protein 8,00Pc_186 Wd domain-containing protein 7,98Pc_3086 Oxidoreductase - 7,97Pc_4963 Hypothetical protein nechadraft_40894 7,97Pc_3961 Alpha-glucosides permease mph2 3 7,97Pc_9095 Ccch zinc finger protein 7,97Pc_2398 Proline rich protein 5 7,97Pc_8480 Dash complex subunit dad1 7,97Pc_11515 --- n/a --- 7,97Pc_5083 Hypothetical protein mac_07684 7,97Pc_2358 Protein 7,95Pc_5253 Hypothetical protein mac_04917 7,95Pc_8317 Dna mismatch repair protein msh3 7,94Pc_6147 Hypothetical protein foxb_03523 7,94Pc_8699 Cutinase transcription factor 1 alpha 7,94Pc_7132 Glutamate 5-kinase 7,92Pc_7986 E3 ubiquitin-protein ligase march6 7,91Pc_5761 Hypothetical protein maa_05674 7,91Pc_8971 Chitin biosynthesis protein chs5 7,91Pc_10088 Anion exchange family protein 7,91Pc_10327 Alkaline phosphatase family protein 7,91Pc_2117 Protein tyrosine phosphatase 7,90Pc_1720 Rpb7-binding protein seb1 7,90Pc_4233 Major facilitator superfamily transporter 7,90Pc_577 Trna (guanine-n -)-methyltransferase 7,89Pc_1173 Splicing factor 3b 7,88Pc_4248 Major facilitator superfamily transporter 7,88Pc_7531 Ferric reductase like transmembrane component 7,87Pc_9234 Camp-regulated phosphoprotein family protein 7,87Pc_3325 Nitrogen assimilation transcription factor nira 7,87Pc_11527 --- n/a --- 7,87Pc_624 Transposase-like protein 7,86Pc_5228 Hypothetical protein mac_05271 7,85Pc_9811 At hook motif family protein 7,85Pc_3845 Mfs transporter 7,85Pc_4666 Integral membrane 7,84Pc_7358 Fungal specific transcription factor 7,84Pc_2136 Protein rds1 7,84Pc_8225 Dna-directed rna polymerase iii subunit rpc6 7,83Pc_938 Telomere length regulation protein elg1 7,83Pc_11179 Mg809 gene product 7,82Pc_3963 Mfs hexose 7,80Pc_622 Transposase-like protein 7,78Pc_3651 Mrna capping enzyme alpha 7,77Pc_4841 Hypothetical protein trividraft_130872, partial 7,77Pc_11065 --- n/a --- 7,77Pc_642 Transmembrane alpha-helix domain-containing protein 7,77Pc_12084 --- n/a --- 7,77Pc_7414 Fructosyl-amino acid oxidase 7,77

Pc_247 Valyl-trna synthetase 7,76Pc_7209 General amidase 7,76Pc_8391 Dihydrofolate reductase 7,75Pc_2153 Protein phosphatase 7,75Pc_10277 Alpha beta hydrolase fold protein 7,75Pc_184 Wd repeat-containing protein 7,74Pc_10352 Aldehyde dehydrogenase 7,73Pc_11598 --- n/a --- 7,72Pc_9585 Brix domain-containing protein 7,72Pc_63 Zinc finger protein 7,72Pc_1016 Sulfur controller 2 7,72Pc_3388 Negative acting factor 7,71Pc_10399 Alanine transaminase-like protein 7,70Pc_69 Zinc finger domain-containing phd-finger 7,70Pc_5255 Hypothetical protein mac_04880 7,69Pc_9583 Bsd domain-containing protein 7,69Pc_5419 Hypothetical protein mac_01987 7,69Pc_3731 Mitochondrial metalloendopeptidase oma1 7,69Pc_2071 Pyridine nucleotide-disulfide oxidoreductase family protein 7,68Pc_7028 Glycine cleavage system t protein 7,67Pc_12104 --- n/a --- 7,67Pc_865 Tho2 protein 7,66Pc_8872 Cleavage and polyadenylylation specificity 7,66Pc_2413 Probable serine-aspartate-rich surface anchored fibrinogen-binding protein 7,64Pc_6200 Hypothetical protein ccm_08796 7,64Pc_11346 Hypothetical protein maa_03796 7,63Pc_3321 Nitrogen regulatory protein area 7,63Pc_142 Wd40 repeat-like-containing domain 7,62Pc_9031 Cell wall glycoprotein 7,62Pc_329 Urease accessory protein ureg 7,61Pc_4925 Hypothetical protein nfia_039000 7,61Pc_3260 Nuclear envelope protein 7,60Pc_2665 Phthalate transporter 7,60Pc_9026 Cell wall proline rich protein 7,60Pc_9577 Btb poz domain-containing protein 7,60Pc_4631 Integral membrane protein 7,60Pc_8053 Duf52 domain-containing protein 7,58Pc_7524 Ferric-chelate reductase 7,58Pc_5333 Hypothetical protein mac_03489 7,58Pc_2725 Phospholipase d 7,58Pc_4538 Isochorismatase domain-containing protein 2a 7,58Pc_5291 Hypothetical protein mac_04275 7,56Pc_11031 -dihydropseudooxynicotine hydrolase 7,56Pc_9800 Atp phosphoribosyltransferase 7,55Pc_4431 Ku70 ku80 n-terminal alpha beta domain-containing protein 7,55Pc_1014 Sun domain protein 7,55Pc_8190 Domain protein 7,55Pc_7925 Endo-beta- - 7,55Pc_11580 --- n/a --- 7,53Pc_10534 Acid phosphatase precursor 7,53Pc_9408 C6 transcription 7,52

Pc_4775 Hypothetical protein tsta_060320 7,52Pc_8695 Cyanamide hydratase 7,52Pc_2554 Porphobilinogen deaminase 7,49Pc_6312 Hscarg dehydrogenase 7,49Pc_11612 --- n/a --- 7,49Pc_11555 --- n/a --- 7,49Pc_2673 Phosphotransferase enzyme family protein 7,49Pc_12015 --- n/a --- 7,49Pc_11270 Hypothetical protein mac_05122 7,49Pc_3379 Negative regulator of the pho system 7,49Pc_2594 Polyketide 7,48Pc_9872 Arrestin 7,47Pc_10516 Actin-binding protein 7,47Pc_5861 Hypothetical protein maa_04097 7,46Pc_9189 Carboxylesterase family protein 7,46Pc_4728 Importin beta-2 subunit 7,45Pc_6697 Golgin subfamily a member 7 erf4 7,45Pc_7674 Fad binding domain protein 7,44Pc_7086 Glutathione s-transferase 7,44Pc_11074 --- n/a --- 7,43Pc_6333 Homocitrate synthase 7,43Pc_1640 Sam-dependent methyltransferase 7,43Pc_1781 Rna binding protein 7,42Pc_6124 Hypothetical protein foxb_11443 7,42Pc_9865 Arsenate reductase 7,41Pc_8164 Domain-containing protein 7,41Pc_10610 Abc1 protein 7,40Pc_11709 --- n/a --- 7,40Pc_5613 Hydroxyproline-rich glycoprotein 7,38Pc_4085 Metal-dependent amidase aminoacylase carboxypeptidase 7,38Pc_10449 Adenosine deaminase family protein 7,37Pc_2608 Poly rna polymerase cid11 7,37Pc_4952 Hypothetical protein nechadraft_54685 7,37Pc_10054 Ankyrin repeat protein 7,36Pc_10092 And nb-arc domain-containing protein 7,36Pc_1649 Salicylate hydroxylase 7,36Pc_8920 Chromatin remodeling complex subunit 7,36Pc_332 Urease accessory protein 7,35Pc_6378 Histone h3 7,34Pc_5132 Hypothetical protein mac_06886 7,34Pc_6847 Glycosyl hydrolase 7,31Pc_11674 --- n/a --- 7,31Pc_2959 Peptidase family m28 family 7,31Pc_11560 --- n/a --- 7,31Pc_7161 Glucose dehydrogenase 7,31Pc_4581 Integral membrane protein 7,31Pc_1820 Ring finger domain-containing protein 7,30Pc_6089 Hypothetical protein hmpref1120_05991 7,29Pc_9749 Atp-dependent rna helicase dhh1 7,29Pc_9578 Btb poz domain-containing protein 7,29Pc_7328 Fungal transcriptional regulatory protein 7,29

Pc_6395 Histone acetyltransferase spt10 7,28Pc_10738 60s ribosomal protein l16 7,28Pc_10057 Ankyrin repeat protein 7,27Pc_473 Ubiquitin carboxyl-terminal hydrolase 7,27Pc_4732 Impact protein 7,26Pc_2017 Rad55 protein 7,26Pc_1621 Scp-like extracellular protein 7,26Pc_414 Ubiquitin-protein ligase molybdopterin-converting factor 7,26Pc_9460 C6 finger domain protein 7,26Pc_9832 Aspartate kinase 7,26Pc_8036 Duf726 domain protein 7,25Pc_894 Thioesterase family protein 7,24Pc_6695 Gpi anchored 7,24Pc_8129 Duf1212 domain membrane protein prm10 7,23Pc_4253 Major facilitator superfamily protein 7,22Pc_1934 Restless-like transposase 7,22Pc_11094 Transposase-like protein 7,22Pc_11092 Uncharacterized protein cpur_00022 7,21Pc_1810 Ring-14 protein 7,20Pc_8013 Duf895 domain membrane protein 7,20Pc_8261 Dna replication licensing factor mcm2 7,20Pc_10334 Aldose 1-epimerase 7,20Pc_7375 Fungal specific transcription 7,20Pc_5922 Hypothetical protein maa_03119 7,20Pc_4875 Hypothetical protein triatdraft_248708 7,20Pc_5002 Hypothetical protein mac_09606 7,19Pc_5315 Hypothetical protein mac_03779 7,19Pc_2126 Protein ssu72 7,19Pc_9777 Atp-citrate synthase subunit 1 7,19Pc_9442 C6 transcription 7,18Pc_8055 Duf500 domain protein 7,18Pc_9705 B-(1-6) glucan synthase 7,18Pc_6900 Glycoside hydrolase family 75 protein 7,18Pc_5516 Hypothetical protein mac_00370 7,18Pc_7081 Glutathione s-transferase 7,16Pc_8894 Citrinin biosynthesis oxygenase 7,16Pc_2144 Protein phosphatase pp2a regulatory subunit b 7,15Pc_9784 Atp-binding cassette sub-family f member 2 7,15Pc_11812 --- n/a --- 7,14Pc_9679 Beta carbonic anhydrase clade d 7,14Pc_9195 Carboxylesterase 7,12Pc_259 Vacuolar protein sorting-associated protein vps4 7,12Pc_9860 Arsenite resistance protein ars2 7,11Pc_10018 Ankyrin repeat protein 7,10Pc_2743 Phosphoglycerate mutase family protein 7,10Pc_8625 Cytochrome b561 7,08Pc_9527 C2h2 finger domain 7,07Pc_7615 Fad-containing monooxygenase 7,07Pc_9413 C6 transcription 7,06Pc_3066 P-hydroxylaminobenzoate lyase 7,06Pc_9625 Bicyclomycin resistance 7,06

Pc_11125 Protein kinase-like domain 7,06Pc_11172 Nol1 nop2 sun domain protein 7,06Pc_2118 Protein tyrosine phosphatase 7,04Pc_4500 K(+) h(+) antiporter 1 7,04Pc_5563 Hypothetical protein maa_09874 7,04Pc_10120 Aminotransferase 7,04Pc_9899 Arginine n-methyltransferase 2-like protein 7,03Pc_7872 Er lumen protein retaining receptor 7,03Pc_3641 Msc7 protein 7,03Pc_1339 Short-chain dehydrogenase reductase sdr 7,03Pc_10752 6-phosphogluconolactonase 7,03Pc_2387 Prolyl oligopeptidase 7,02Pc_8612 Cytochrome c oxidase polypeptide vi 7,01Pc_3316 Nlp p60 protein 7,01Pc_6867 Glycoside hydrolase family 95 7,01Pc_9484 C6 and c2h2 transcription factor -like protein 7,00Pc_10400 Alanine racemase family protein 7,00Pc_8942 Choline transport 7,00Pc_2966 Peptidase dipeptidase 7,00Pc_3499 Nad dependent epimerase dehydratase family protein 6,99Pc_4495 Kelch repeat protein 6,99Pc_7104 Glutamyl-trna amidotransferase subunit a 6,99Pc_8304 Dna polymerase gamma 6,98Pc_1510 Serine threonine-protein kinase 6,97Pc_4351 Leucyl-trna synthetase 6,97Pc_10485 Acyl- dehydrogenase 6,97Pc_6972 Glycoside hydrolase family 2 protein 6,97Pc_3108 Ornithine carbamoyltransferase 6,96Pc_10450 Adenosine deaminase 6,96Pc_6938 Glycoside hydrolase family 31 protein 6,95Pc_5434 Hypothetical protein mac_01738 6,95Pc_10490 Acyl- dehydrogenase 6,94Pc_9009 Cell wall serine-threonine-rich galactomannoprotein mp1 6,94Pc_2312 Protein 6,93Pc_7295 Fzr protein 6,92Pc_9292 C6 zinc finger domain-containing protein 6,92Pc_2998 Pci domain-containing protein 6,92Pc_10667 Aaa family atpase 6,92Pc_3868 Mfs transporter 6,92Pc_724 Transcription initiation factor iif 6,92Pc_8925 Chromate transporter 6,91Pc_3219 Nucleolar protein 12 6,91Pc_6139 Hypothetical protein foxb_06019 6,90Pc_5013 Hypothetical protein mac_09283 6,90Pc_11137 Protein 6,90Pc_10973 2-deoxy-d-gluconate 3- 6,90Pc_10932 26s proteasome regulatory subunit-like protein 6,90Pc_10026 Ankyrin repeat protein 6,90Pc_1574 Secretory phospholipase a2 6,90Pc_9930 Ap-2 complex subunit beta 6,89Pc_2701 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomera 6,88

Pc_1356 Short-chain dehydrogenase reductase 2 6,88Pc_985 Synaptobrevin 6,87Pc_10444 Adenylate kinase 6,87Pc_3732 Mitochondrial membrane protein pet127 6,87Pc_5910 Hypothetical protein maa_03315 6,86Pc_8066 Duf323 domain-containing protein 6,86Pc_10928 2og-fe oxygenase 6,86Pc_552 Truncated het-r 6,85Pc_7217 Gdp-mannose pyrophosphorylase 6,84Pc_5491 Hypothetical protein mac_00803 6,84Pc_5125 Hypothetical protein mac_07025 6,82Pc_5362 Hypothetical protein mac_03041 6,82Pc_5393 Hypothetical protein mac_02361 6,82Pc_7126 Glutamate decarboxylase 6,82Pc_9926 Ap-3 complex subunit delta 6,81Pc_6447 High-affinity glucose transporter rgt2 6,81Pc_5782 Hypothetical protein maa_05360 6,80Pc_9091 Ccr4-not transcription complex subunit 7 6,80Pc_9813 At dna binding 6,80Pc_1653 Salicylate hydroxylase 6,80Pc_10879 3-isopropylmalate dehydrogenase 6,80Pc_525 Tyrosinase 2 6,79Pc_8852 Coenzyme a 6,79Pc_495 U3 snornp-associated protein utp11 6,79Pc_5956 Hypothetical protein maa_02619 6,79Pc_917 F-box tpr repeat protein pof3 6,78Pc_636 Transmembrane gtpase fzo1 6,78Pc_4095 Membrane-associated progesterone receptor component 1 6,78Pc_6355 Hlh transcription 6,78Pc_1814 Ring finger protein 6,78Pc_3254 Nuclear import and export protein 6,77Pc_6477 Heterokaryon incompatibility protein 6,76Pc_1978 Regulator of g-protein signaling domain-containing protein 6,76Pc_4492 Kelch repeat protein 6,76Pc_896 Thioesterase family protein 6,76Pc_6687 Gpi ethanolamine phosphate transferase 1 6,75Pc_11307 Hypothetical protein maa_09969 6,74Pc_1151 Squalene phytoene synthase 6,74Pc_2580 Polyketide synthase 6,74Pc_10682 Pc21g06840 6,74Pc_4169 Mannose-1-phosphate guanyltransferase 6,73Pc_7149 Glucose transporter 6,72Pc_5231 Hypothetical protein mac_05231 6,71Pc_8097 Duf1740 domain containing protein 6,71Pc_10892 3-hydroxyanthranilate -dioxygenase 6,71Pc_2920 Peptidyl-prolyl isomerase cwc27 6,71Pc_9014 Cell wall protein 6,71Pc_4152 Mate efflux family protein 6,70Pc_10456 Adam 8 precursor 6,70Pc_6248 Hypothetical protein ani_1_3414014 6,68Pc_8339 Dna damage tolerance protein rad31 6,68

Pc_2591 Polyketide 6,68Pc_6158 Hypothetical protein foxb_01009 6,67Pc_11186 Internalin protein 6,67Pc_2871 Pex2 pex12 amino terminal region 6,67Pc_12105 --- n/a --- 6,67Pc_2129 Protein sco1 6,67Pc_6402 Histone acetylase complex subunit 6,67Pc_10189 Amidohydrolase family protein 6,66Pc_1751 Rna polymerase iii transcription factor 6,66Pc_237 Nacht and wd domain protein 6,65Pc_3313 Non-heme chloroperoxidase 6,65Pc_4342 Lim domain-containing protein 6,65Pc_4557 Invertase precursor 6,65Pc_1179 Spindle pole body interacting protein 6,65Pc_1539 Serine threonine phosphatase 2c ptc2 6,64Pc_1 Zz type zinc finger domain-containing protein 6,64Pc_7882 Epoxide hydrolase 6,64Pc_7023 Glycine-rich rna-binding protein 6,64Pc_9015 Cell wall protein 6,64Pc_4440 Kinetochore protein 6,64Pc_9803 Atp dependent rna helicase 6,63Pc_4100 Membrane transporter 6,63Pc_3727 Mitochondrial oxaloacetate transport protein 6,62Pc_1401 Short-chain dehydrogenase reductase family 6,61Pc_143 Wd40 repeat-like-containing domain 6,61Pc_3779 Mitochondrial complex i protein fmp36 6,60Pc_1011 Superoxide dismutase 6,60Pc_5649 Hypothetical protein maa_07842 6,60Pc_1404 1-acyl dihydroxyacetone phosphate reductase 6,60Pc_4018 Methyltransferase - 6,60Pc_4108 Membrane fusion mating protein fig1 6,60Pc_3198 Nucleosome binding protein 6,60Pc_6844 Glycosyl hydrolase family 43 protein 6,60Pc_10860 3-oxoacyl-(acyl-carrier-protein) reductase 6,59Pc_9107 Cation-transporting atpase 4 6,58Pc_4379 Lanosterol synthase 6,58Pc_5483 Hypothetical protein mac_00890 6,56Pc_1735 Rna-binding la domain protein 6,56Pc_10420 Af323585_1beta transducin-like protein het-d2y 6,56Pc_9817 Aspartyl partial 6,56Pc_9175 Carboxymethylenebutenolidase 6,55Pc_2406 Proline iminopeptidase 6,55Pc_8252 Dna topoisomerase 2 6,55Pc_9115 Cation diffusion facilitator 10 6,54Pc_6005 Hypothetical protein maa_01834 6,53Pc_10582 Acetolactate synthase 6,53Pc_7793 Exocyst complex component sec5 6,53Pc_3252 Nuclear migration protein nudf 6,52Pc_693 Transcriptional regulator 6,51Pc_3501 Nad dependent epimerase dehydratase family protein 6,51Pc_4646 Integral membrane protein 6,51

D)

Pc_4727 Importin beta-5 6,23Pc_1169 Splicing factor u2af 65 kda subunit 6,21Pc_4547 Iron sulfur cluster assembly protein 1 6,20Pc_2220 Protein kinase 6,20Pc_1530 Serine threonine protein kinase 6,20Pc_700 Transcriptional coactivator hfi1 6,20Pc_12031 --- n/a --- 6,20Pc_11415 Histidine kinase tcs1p 6,20Pc_10947 26s protease regulatory subunit 6a 6,19Pc_2534 Potassium transporter 5 6,19Pc_5880 Hypothetical protein maa_03916 6,18Pc_9237 Camp-independent regulatory protein pac2 6,17Pc_3723 Mitochondrial phosphate carrier protein 6,17Pc_5122 Hypothetical protein mac_07068 6,16Pc_2964 Peptidase family m1 6,16Pc_10274 Alpha beta hydrolase fold protein 6,16Pc_5289 Hypothetical protein mac_04283 6,15Pc_9575 Btb poz fold domain containing protein 6,15Pc_2342 Protein 6,15Pc_11854 --- n/a --- 6,14Pc_11025 -dimethyl-8-ribityllumazine synthase 6,14Pc_1015 Sulphydryl oxidase 6,14Pc_5030 Hypothetical protein mac_09042 6,14Pc_5603 Hypothetical protein maa_09092 6,14Pc_9215 Carbohydrate esterase family 3 protein 6,14Pc_5094 Hypothetical protein mac_07417 6,14Pc_5270 Hypothetical protein mac_04465 6,14Pc_6484 Heterokaryon incompatibility protein 6,12Pc_9150 Cas1 appressorium specific protein 6,12Pc_7849 Esterase family protein 6,11Pc_5465 Hypothetical protein mac_01234 6,11Pc_5717 Hypothetical protein maa_06459 6,10Pc_3542 N2227-like protein 6,09Pc_8812 Conserved hypothetical protein 6,08Pc_3977 Mfs alpha-glucoside 6,08Pc_912 Tgf beta receptor associated protein 1 6,08Pc_709 Transcription-silencing protein clr2 6,08Pc_1994 Ras small monomeric gtpase 6,08Pc_9757 Atp-dependent rna helicase 6,08Pc_541 Tuberous sclerosis 1 6,07Pc_2086 Purine-cytosine permease 6,07Pc_5853 Hypothetical protein maa_04183 6,05Pc_9474 C6 finger domain 6,05Pc_951 Negative cofactor 2 complex subunit beta 6,05Pc_2938 Peptide methionine sulfoxide reductase msrb msra 6,05Pc_8614 Cytochrome c oxidase polypeptide iv 6,05Pc_7765 Extracellular matrix protein precursor 6,05Pc_7351 Fungal specific transcription factor domain protein 6,03Pc_6230 Hypothetical protein bddg_04709 6,02Pc_11204 Hypothetical protein trividraft_72964 6,02Pc_3247 Nuclear pore complex protein nup107 6,01

Pc_4354 Leucine rich repeat protein 6,01Pc_1729 Rnapii degradation factor def1 6,01Pc_6294 Hst3 protein 5,99Pc_11907 --- n/a --- 5,99Pc_11595 --- n/a --- 5,99Pc_10143 Amino acid transporter 5,99Pc_9698 Bar domain-containing protein 5,99Pc_7330 Fungal specific transcription factor domain-containing protein 5,99Pc_8149 Double-strand-break repair protein rad21 5,98Pc_2859 Pfs domain-containing protein 5,98Pc_11269 Hypothetical protein mac_05334 5,98Pc_6058 Hypothetical protein maa_00684 5,98Pc_6338 Homeodomain-containing protein 5,97Pc_2908 Peroxin 22-like protein 5,97Pc_1958 Related to lysophospholipase 5,97Pc_5544 Hypothetical protein maa_10463 5,96Pc_1989 Ras-related protein rab7 5,96Pc_158 Wd repeat-containing protein 5,96Pc_6136 Hypothetical protein foxb_07975 5,96Pc_8372 Dihydroxyacetone synthase 5,95Pc_4605 Integral membrane protein 5,94Pc_3933 Mfs multidrug 5,94Pc_8131 Duf1183 domain protein 5,94Pc_3445 Nadh:flavin oxidoreductase nadh oxidase 5,93Pc_3740 Mitochondrial inheritance component mdm12 5,93Pc_9915 Arf-like gtpase atypical 5,93Pc_6567 Heat-labile a chain 5,93Pc_5248 Hypothetical protein mac_05011 5,92Pc_7446 Fmn binding 5,92Pc_38 Zip metal ion 5,92Pc_2343 Protein 5,91Pc_7881 Epoxide hydrolase 5,90Pc_4366 Lea domain-containing protein 5,90Pc_3462 Nadh-ubiquinone oxidoreductase 213 kda subunit 5,90Pc_6374 Histone h4 5,90Pc_3909 Mfs multidrug transporter 5,89Pc_3193 Nucleotide-binding domain containing protein 5,89Pc_1069 Beta-n-acetylhexosaminidase 5,89Pc_8911 Chromosome segregation atpase 5,89Pc_1645 Salicylate hydroxylase (salicylate 1-monooxygenase) 5,89Pc_9465 C6 finger domain 5,88Pc_5137 Hypothetical protein mac_06795 5,87Pc_11584 --- n/a --- 5,87Pc_830 Toxin biosynthesis 5,87Pc_365 Upf0023 family protein 5,86Pc_10051 Ankyrin repeat protein 5,86Pc_8547 Cytochrome p450 6a1 5,86Pc_7202 General amino-acid permease gap1 5,85Pc_7357 Fungal specific transcription factor 5,85Pc_7461 Flavohemoglobin 5,85Pc_8032 Duf775 domain protein 5,85

Pc_8666 Cyclopropane-fatty-acyl-phospholipid synthase 5,85Pc_3439 Nadh:ubiquinone oxidoreductase subunit 5,85Pc_3343 Nitrate assimilation regulatory protein nira 5,85Pc_7462 Flavohemoglobin 5,83Pc_10421 Af323584_1beta transducin-like protein het-e2c*40 5,82Pc_9192 Carboxylesterase a 5,82Pc_2963 Peptidase family m20 m25 m40 protein 5,82Pc_1528 Serine threonine protein kinase 5,81Pc_9532 C2h2 finger domain 5,81Pc_9399 C6 transcription 5,80Pc_10369 Aldehyde dehydrogenase 5,80Pc_11840 --- n/a --- 5,79Pc_11641 --- n/a --- 5,79Pc_10617 Abc transporter with duplicated atpase domains 5,79Pc_12050 --- n/a --- 5,79Pc_8218 Dna-repair protein rad2 5,79Pc_1264 Small nucleolar ribonucleoprotein complex subunit 5,79Pc_8459 Dead deah box rna helicase 5,79Pc_416 Ubiquitin-protein ligase 5,78Pc_944 Tbc domain-containing protein 5,78Pc_3821 Minichromosome loss protein 5,77Pc_3869 Mfs transporter 5,77Pc_7199 General negative regulator of transcription subunit 4 5,77Pc_7946 Elongation factor 2 5,76Pc_8886 Class ii aldolase adducin domain containing protein 5,76Pc_4490 Keratinolytic protein 5,76Pc_10001 Ankyrin repeat-containing 5,76Pc_5616 Hypothetical protein maa_08742 5,76Pc_5528 Hypothetical protein mac_00246 5,75Pc_6316 Hrq family protein 5,75Pc_5151 Hypothetical protein mac_06579 5,74Pc_7491 Flavin containing polyamine 5,73Pc_1280 Slx8 protein 5,72Pc_36 Nadph:quinone reductase 5,72Pc_7942 Elongation factor 3 5,71Pc_2033 Quinate permease 5,70Pc_2731 Phospholipase c 5,70Pc_7772 Extracellular dipeptidyl-peptidase dpp4 5,70Pc_2575 Polyketide synthase 5,68Pc_5941 Hypothetical protein maa_02844 5,68Pc_1422 Short chain dehydrogenase 5,68Pc_3555 N-alpha-acetyltransferase 30 5,68Pc_4436 Kinetochore protein nuf2 5,68Pc_197 Wasp-interacting protein vrp1p 5,67Pc_2077 Pyoverdine dityrosine biosynthesis 5,67Pc_8263 Dna replication licensing factor mcm10 5,66Pc_6450 High affinity nicotinic acid plasma membrane permease 5,66Pc_5055 Hypothetical protein mac_08420 5,66Pc_7383 Fungal specific transcription 5,65Pc_1535 Serine threonine protein 5,65Pc_6858 Glycosyl 5,65

Pc_8011 Duf907 domain-containing protein 5,65Pc_175 Mitogen-activated protein kinase organizer 1 5,65Pc_6067 Hypothetical protein maa_00437 5,64Pc_2223 Protein kinase 5,64Pc_9266 Calcium calmodulin-dependent protein kinase 5,63Pc_7591 Family protein 5,63Pc_8471 Dcp1-like decapping family protein 5,63Pc_7048 Glyceraldehyde-3-phosphate dehydrogenase 5,63Pc_6168 Hypothetical protein fg04457.1 5,62Pc_4308 Longevity-assurance protein 5,62Pc_9364 C6 transcription factor 5,61Pc_5976 Hypothetical protein maa_02342 5,61Pc_2844 Ph-response regulator protein pala rim20 5,59Pc_4852 Hypothetical protein triatdraft_86706 5,59Pc_1858 Ribosomal protein l32 5,58Pc_2853 Ph domain-containing protein 5,58Pc_1557 Ser thr protein phosphatase family protein 5,58Pc_8640 Cysteine-rich secreted protein 5,58Pc_7084 Glutathione s-transferase 5,58Pc_7860 Erp1 protein precursor 5,58Pc_10945 26s protease regulatory subunit 7 5,57Pc_3564 N-acetyl-gamma-glutamyl-phosphate reductase 5,57Pc_11057 Hypothetical protein dotsedraft_68352 5,56Pc_1373 Short-chain dehydrogenase 5,56Pc_8905 Chromosome segregation protein 5,55Pc_649 Protein transporter sec61 subunit gamma 5,55Pc_11800 --- n/a --- 5,55Pc_11452 Candidate effector 5 5,55Pc_2975 Peptidase a4 family protein 5,55Pc_5391 Hypothetical protein mac_02415 5,55Pc_11402 Hypothetical protein bba_09791 5,55Pc_931 Terpene synthase 5,55Pc_4976 Hypothetical protein mycgrdraft_92792 5,55Pc_3848 Mfs transporter 5,54Pc_6389 Histone deacetylase 5,54Pc_5166 Hypothetical protein mac_06331 5,53Pc_6150 Hypothetical protein foxb_03225 5,53Pc_6746 Gmf family protein 5,53Pc_5366 Hypothetical protein mac_02923 5,53Pc_5586 Hypothetical protein maa_09421 5,53Pc_2710 Phosphomevalonate kinase 5,53Pc_5894 Hypothetical protein maa_03570 5,53Pc_11444 Copper resistance protein crd2 5,53Pc_11489 --- n/a --- 5,53Pc_7429 Frequency clock partial 5,53Pc_11912 --- n/a --- 5,53Pc_9258 Calcium p-type atpase 5,52Pc_8953 Cholesterol oxidase precursor 5,52Pc_10672 A49-like rna polymerase i associated factor 5,52Pc_8598 Cytochrome p450 5,51Pc_7794 Exocyst complex component sec15 5,51

Pc_714 Transcription initiation factor tfiid subunit 9 5,50Pc_9663 Beta-galactosidase 5,50Pc_5495 Hypothetical protein mac_00690 5,50Pc_2555 Porphobilinogen deaminase 5,50Pc_942 Teichoic acid biosynthesis protein c 5,48Pc_6354 Hlh transcription 5,48Pc_6356 Hlh transcription 5,48Pc_7838 Eukaryotic aspartyl protease 5,48Pc_11749 --- n/a --- 5,48Pc_4670 Integral membrane 5,48Pc_850 Thymine dioxygenase 5,48Pc_3780 Mitochondrial co-chaperone 5,48Pc_5335 Hypothetical protein mac_03467 5,47Pc_2788 Phosphatidylethanolamine n-methyltransferase 5,47Pc_10495 Acyl- 5,47Pc_8356 Dipeptidyl peptidase iii 5,47Pc_2139 Protein prenyltransferase 5,46Pc_11691 --- n/a --- 5,46Pc_4372 Late sexual development protein 5,45Pc_5820 Hypothetical protein maa_04859 5,45Pc_7630 Fad dependent oxidoreductase superfamily 5,44Pc_3206 Nucleoside transporter family 5,44Pc_6704 Golgi matrix protein 5,44Pc_3139 Oligopeptide transporter opt 5,44Pc_11730 --- n/a --- 5,43Pc_6274 Hydroxymethylglutaryl- synthase 5,43Pc_4160 Map kinase kinase emk1 5,42Pc_6629 Guanine nucleotide exchange factor vps9 5,42Pc_1307 Siderophore regulation protein 5,42Pc_6777 Glycosyltransferase family 64 protein 5,42Pc_10409 Agmatine deiminase 5,42Pc_2992 Penicillin-binding 5,41Pc_5274 Hypothetical protein mac_04426 5,41Pc_461 Ubiquitin carboxyl-terminal hydrolase 2 5,41Pc_2314 Protein 5,40Pc_1578 Secretory lipase family protein 5,40Pc_3113 Origin recognition complex subunit 2 5,39Pc_5850 Hypothetical protein maa_04252 5,38Pc_5245 Hypothetical protein mac_05017 5,38Pc_1267 Small nuclear ribonucleoprotein sm d3 5,38Pc_3927 Mfs multidrug 5,38Pc_2898 Peroxisomal carrier protein 5,38Pc_1608 Sec8 exocyst complex component specific domain-containing protein 5,38Pc_9219 Carbamoyl-phosphate synthase arginine-specific large chain 5,37Pc_663 Translation initiation factor eif-2b subunit delta 5,37Pc_127 Wsc domain-containing protein 5,37Pc_10539 Acid phosphatase 5,37Pc_1309 Siderophore iron transporter mirb 5,37Pc_8999 Centromere binding protein b 5,37Pc_7581 Family protein 5,36Pc_8135 Dual specificity mitogen-activated protein kinase kinase 1 5,36

Pc_11370 Hypothetical protein glarea_10135 5,35Pc_3950 Monocarboxylate transporter 8 5,35Pc_6901 Glycoside hydrolase family 72 protein 5,34Pc_10215 Amidase 5,34Pc_5900 Hypothetical protein maa_03510 5,34Pc_11619 --- n/a --- 5,34Pc_11552 --- n/a --- 5,34Pc_1756 Rna polymerase ii-associated protein 5,34Pc_8525 Cytochrome p450 monooxygenase 5,34Pc_6482 Heterokaryon incompatibility protein 5,33Pc_11174 Negative acting factor 5,32Pc_1135 Sterol desaturase 5,32Pc_9983 Ankyrin repeat-containing 5,32Pc_11814 --- n/a --- 5,31Pc_5970 Hypothetical protein maa_02381 5,31Pc_5214 Hypothetical protein mac_05538 5,31Pc_4486 Ketoreductase 5,31Pc_2237 Protein disulfide-isomerase 5,31Pc_10069 Ankyrin repeat containing protein 5,30Pc_10953 2-succinylbenzoate- ligase 5,29Pc_4408 L-asparaginase precursor 5,29Pc_7298 Fungal zn binuclear cluster domain containing protein 5,29Pc_585 Tripeptidyl peptidase precursor 5,29Pc_2641 Pirin 5,29Pc_6748 Glyoxalase family protein 5,29Pc_5279 Hypothetical protein mac_04386 5,28Pc_3538 Nacht and ankyrin domain protein 5,27Pc_3632 Mucin-like protein 1 5,27Pc_7288 G-patch domain 5,27Pc_8221 Dna-directed rna polymerases ii 24 kda polypeptide 5,27Pc_3486 Nad-dependent deacetylase sirtuin-5 5,27Pc_3196 Nucleotide excision repair protein rad23 5,27Pc_2640 Pirin domain 5,26Pc_5180 Hypothetical protein mac_06139 5,25Pc_10498 Acyl binding protein 5,25Pc_11035 -dialkylglycine decarboxylase 5,25Pc_35 Zinc-binding alcohol 5,25Pc_10715 60s ribosomal protein l34 5,25Pc_6893 Glycoside hydrolase family 75 protein 5,25Pc_9259 Calcium p-type atpase 5,24Pc_7163 Glucosamine-fructose-6-phosphate aminotransferase 5,24Pc_4549 Iron only hydrogenase large subunit domain-containing protein 5,24Pc_6483 Heterokaryon incompatibility protein 5,24Pc_4264 Magnesium-translocating p-type atpase 5,23Pc_8425 Developmental regulator flba 5,23Pc_7544 Fatty-acid amide hydrolase 5,23Pc_4206 Major facilitator superfamily transporter 5,23Pc_9671 Beta- -endoglucanase 5,23Pc_8137 Dtdp-d-glucose -dehydratase 5,22Pc_10309 Allantoate permease 5,22Pc_2627 Plasma membrane g-protein coupled receptor 5,22

Pc_5525 Hypothetical protein mac_00258 5,21Pc_1807 Ring-5 like protein 5,20Pc_5349 Hypothetical protein mac_03207 5,20Pc_3154 Oligo- -glucosidase 5,20Pc_1175 Splicing factor 3a subunit 2 5,20Pc_8758 Cord and cs domain-containing protein 5,20Pc_3695 Mitotic control protein dis3 5,20Pc_1629 Sarcosine oxidase 5,19Pc_1209 Mitochondrial carrier 5,19Pc_10128 Aminomethyl transferase 5,19Pc_5602 Hypothetical protein maa_09127 5,18Pc_4883 Hypothetical protein thite_51372, partial 5,18Pc_4477 Killer kp4 5,18Pc_7490 Flavin reductase like domain-containing protein 5,18Pc_7170 Glucokinase regulator family 5,18Pc_7854 Essential cytoplasmic protein 5,18Pc_6533 Het domain protein 5,18Pc_3150 Oligopeptidase family protein 5,17Pc_10067 Ankyrin repeat domain containing protein 5,17Pc_8187 Domain protein 5,16Pc_713 Transcription initiation protein spt5 5,16Pc_5033 Hypothetical protein mac_08935 5,16Pc_12083 --- n/a --- 5,16Pc_7743 F-box and wd domain-containing protein 5,15Pc_10564 Acetylornithine aminotransferase 5,15Pc_9106 Cation-transporting atpase 4 5,14Pc_2607 Poly rna polymerase cid13 5,14Pc_7981 Ebs-bah-phd domain-containing protein 5,14Pc_4762 Hypothetical protein 5,14Pc_6866 Glycoside hydrolase family 95 protein 5,13Pc_4617 Integral membrane protein 5,13Pc_4437 Kinetochore protein mis13 5,11Pc_11318 Hypothetical protein maa_08122 5,11Pc_11565 --- n/a --- 5,11Pc_893 Thioesterase family protein 5,11Pc_1123 Stress responsive a b barrel domain protein 5,11Pc_5172 Hypothetical protein mac_06212 5,11Pc_6887 Glycoside hydrolase family 76 protein 5,11Pc_299 Vacuolar atp synthase subunit b 5,10Pc_6597 Haloalkanoic acid 5,09Pc_10624 Abc transporter 5,09Pc_839 Tol protein 5,09Pc_9748 Atp-dependent rna helicase dhx8 5,09Pc_5140 Hypothetical protein mac_06767 5,09Pc_4289 Lysophospholipase plb1 5,08Pc_10034 Ankyrin repeat protein 5,08Pc_4886 Hypothetical protein thite_2117760 5,07Pc_5867 Hypothetical protein maa_04053 5,07Pc_4621 Integral membrane protein 5,07Pc_9438 C6 transcription 5,07Pc_6582 Heat shock protein 30 5,07

Pc_11076 Augustus_masked-scaffold559-abinit-gene- -mrna-1 5,07Pc_9498 C2h2 type zinc finger domain protein 5,07Pc_10701 60s ribosome biogenesis protein 5,06Pc_9088 Cdk-activating kinase assembly factor mat1 5,06Pc_2867 Pfs domain protein 5,06Pc_8002 Dynamin family protein 5,05Pc_5240 Hypothetical protein mac_05054 5,05Pc_10780 5-oxoprolinase 5,04Pc_4259 Major facilitator superfamily protein 5,04Pc_8077 Duf221 domain-containing protein 5,04Pc_6969 Glycoside hydrolase family 2 protein 5,03Pc_320 Uroporphyrinogen decarboxylase 5,03Pc_2108 Proteinase inhibitor i4 5,03Pc_11006 -like protein 5,03Pc_3568 Myosin-5 5,02Pc_4927 Hypothetical protein nfia_006180 5,02Pc_2777 Phosphatidylinositol-specific phospholipase c 5,02Pc_2745 Phosphoglycerate mutase family protein 5,01Pc_11149 Predicted protein 5,00Pc_5121 Hypothetical protein mac_07069 4,99Pc_7052 Glutathione-dependent formaldehyde-activating enzyme 4,99Pc_2728 Phospholipase carboxylesterase family protein 4,99Pc_7430 Frag1 dram sfk1 family protein 4,99Pc_4022 Methyltransferase 4,99Pc_10454 Adaptor complexes medium subunit family protein 4,99Pc_9785 Atp-binding cassette 4,98Pc_7479 Flavin-binding monooxygenase, putative 4,98Pc_7977 Ef hand domain-containing protein 4,97Pc_6874 Glycoside hydrolase family 79 protein 4,97Pc_9703 B3 4 domain protein 4,97Pc_8319 Dna mismatch repair protein 4,96Pc_4219 Major facilitator superfamily transporter 4,96Pc_10360 Aldehyde dehydrogenase 4,96Pc_4399 L-ornithine 5-monooxygenase 4,96Pc_468 Ubiquitin carboxyl-terminal hydrolase 4,95Pc_11085 Uncharacterized protein cpur_07363 4,95Pc_8722 Cupin 2 conserved barrel domain protein 4,95Pc_2561 Polysaccharide lyase family 7 protein 4,95Pc_9508 C2h2 transcription factor 4,95Pc_1545 Serine hydroxymethyltransferase 4,95Pc_4641 Integral membrane protein 4,94Pc_8704 Cutinase gene palindrome-binding protein 4,94Pc_6618 Guanylate kinase 4,94Pc_4361 Letm1-like protein 4,93Pc_879 Thioredoxin reductase 4,92Pc_483 Cytochrome b-c1 complex subunit 7 4,91Pc_10691 Hypothetical protein trividraft_64278 4,91Pc_5841 Hypothetical protein maa_04313 4,91Pc_742 Transcription factor cys6 4,91Pc_8464 Dead box atp-dependent rna 4,91Pc_311 V8-like glu-specific endopeptidase 4,91

Pc_9030 Cell wall glycoprotein 4,91Pc_11984 --- n/a --- 4,91Pc_2768 Phospho-2-dehydro-3-deoxyheptonate aldolase 4,90Pc_7450 Fluconazole resistance protein 1 4,89Pc_7121 Glutamate-cysteine ligase modifier subunit 4,89Pc_5312 Hypothetical protein mac_03837 4,89Pc_5694 Hypothetical protein maa_06963 4,88Pc_6453 High affinity glucose transporter ght1 4,88Pc_8499 D-amino acid 4,88Pc_9395 C6 transcription 4,88Pc_1235 Snf2 family helicase 4,88Pc_6833 Glycosylphosphatidylinositol anchor biosynthesis protein 11 4,87Pc_2368 Proteasome component y13 4,87Pc_4315 Long chain fatty alcohol oxidase 4,87Pc_11601 --- n/a --- 4,87Pc_2255 Protein 4,87Pc_7741 F-box domain containing protein 4,86Pc_3120 Opt oligopeptide transporter 4,86Pc_11616 --- n/a --- 4,85Pc_11258 Hypothetical protein mac_07619 4,85Pc_10305 Allantoate transport protein 4,85Pc_4509 Isopenicillin n- 4,85Pc_1181 Spindle pole body 4,84Pc_9138 Casein kinase ii beta subunit 4,83Pc_5975 Hypothetical protein maa_02346 4,83Pc_5464 Hypothetical protein mac_01289 4,83Pc_8136 Dual specificity 4,83Pc_11472 Alpha- -mannosidase family protein 4,82Pc_4036 Methyl- -binding domain-containing protein 4 4,82Pc_7278 G-protein coupled 4,82Pc_7281 G-protein beta wd-40 repeats containing 4,82Pc_950 Taurine catabolism dioxygenase 4,82Pc_3535 Nacht and ankyrin domain protein 4,82Pc_10730 60s ribosomal protein l2 4,81Pc_2151 Protein phosphatase 2a regulatory b subunit 4,81Pc_3248 Nuclear pore complex protein an-nup82 4,81Pc_4694 Ino80 chromatin remodeling complex protein 4,80Pc_1479 Serine threonine-protein kinase srpk2 4,80Pc_4369 Ldb17 protein 4,80Pc_5266 Hypothetical protein mac_04663 4,80Pc_5601 Hypothetical protein maa_09134 4,80Pc_6630 Guanine nucleotide exchange factor synembryn-like protein 4,80Pc_2088 Purine permease 4,79Pc_7992 Dynein light intermediate chain 4,79Pc_2886 Peroxisomal membrane protein pex16 4,78Pc_3827 Microtubule associated protein 4,78Pc_10398 Alanine-glyoxylate aminotransferase 4,78Pc_9561 Bzip transcription factor 4,78Pc_7190 Geranylgeranyl diphosphate synthase 4,77Pc_10638 Abc transporter 4,76Pc_8220 Dna-entry nuclease 4,76

Pc_3979 Mfs allantoate transporter 4,76Pc_3687 Mmp37-like protein 4,76Pc_3083 Oxidoreductase domain protein 4,76Pc_6734 Gnat family 4,76Pc_5888 Hypothetical protein maa_03728 4,76Pc_1868 Ribosomal l32p family protein 4,76Pc_9488 C3hc4 type (ring finger) zinc finger containing protein 4,75Pc_9249 Calcium-dependent protein kinase 4,75Pc_8588 Cytochrome p450 4,75Pc_6410 Histidine kinase m27mp 4,74Pc_6824 Glycosyltransferase family 2 protein 4,74Pc_6507 Het-e 4,74Pc_10604 Ace2_trire ame: full=transcription factor aceii 4,74Pc_238 Vegetative incompatibility protein het-e-1 4,73Pc_1699 Rta1 domain 4,73Pc_4481 Kh domain rna-binding protein 4,73Pc_1147 Glucan 4-alpha-glucosidase 4,73Pc_6401 Histone acetyltransferase 4,72Pc_4565 Intracellular protein transport-like protein 4,72Pc_968 Tam domain 4,72Pc_5788 Hypothetical protein maa_05306 4,72Pc_6954 Glycoside hydrolase family 29 protein 4,72Pc_3830 Microsomal glutathione s-transferase 4,72Pc_8554 Cytochrome p450 3a30 4,71Pc_1162 Sporulation protein rmd1 4,71Pc_1381 Short-chain 4,70Pc_4132 Mediator of rna polymerase ii transcription subunit 5 4,70Pc_2954 Peptidase family t4 protein 4,70Pc_10566 Acetylglutamate synthase 4,70Pc_10935 26s proteasome regulatory subunit rpn-8 4,69Pc_6223 Hypothetical protein ccm_01614 4,69Pc_6018 Hypothetical protein maa_01533 4,69Pc_6772 Glycosyltransferase family 90 protein 4,68Pc_7646 Fad dependent 4,68Pc_8961 Chitinase 4,68Pc_2578 Polyketide synthase 4,67Pc_5937 Hypothetical protein maa_02871 4,67Pc_7139 Glucose-methanol-choline oxidoreductase 4,67Pc_4124 Mei5 protein 4,67Pc_8502 D- 4,67Pc_3621 Multicopper oxidase family protein 4,66Pc_10583 Acetolactate synthase 4,66Pc_10791 5 -3 exoribonuclease 2 4,65Pc_523 Tyrosinase precursor 4,65Pc_7318 Fungal transcriptional regulatory protein 4,65Pc_11450 Cnd01770-like protein 4,65Pc_7043 Glycerol kinase 4,65Pc_5320 Hypothetical protein mac_03720 4,65Pc_8562 Cytochrome p450 4,65Pc_6420 Histidine kinase 1 4,65Pc_8262 Dna replication licensing factor mcm2 4,64

Pc_5034 Hypothetical protein mac_08894 4,64Pc_5416 Hypothetical protein mac_02016 4,63Pc_7515 Feruloyl esterase b 4,63Pc_1205 Sorbitol dehydrogenase 4,63Pc_10302 Allantoinase 4,62Pc_7463 Flavodoxin and radical sam domain protein 4,62Pc_8455 Decaprenyl-diphosphate synthase subunit 1 4,61Pc_3539 Na+ h+ antiporter cnh1 4,61Pc_9490 C2hc5 finger protein 4,61Pc_8390 Dihydrofolate reductase 4,61Pc_4692 Inorganic pyrophosphatase 4,61Pc_8902 Chy zinc finger domain protein 4,61Pc_5834 Hypothetical protein maa_04621 4,60Pc_7235 Gas2 domain containing protein 4,60Pc_6452 High affinity methionine permease 4,60Pc_2349 Protein 4,60Pc_11028 -dihydroxyhept-2-ene- -dioic acid aldolase 4,60Pc_7191 Gephyrin 4,59Pc_10 Zn 2cys6 transcription factor 4,59Pc_1892 Ribokinase 4,59Pc_10074 Ankyrin partial 4,59Pc_4269 Srf-type transcription factor 4,59Pc_7347 Fungal specific transcription factor domain-containing protein 4,59Pc_6817 Glycosyltransferase family 21 protein 4,59Pc_1505 Serine threonine-protein kinase chk1 4,59Pc_4274 M6 family metalloprotease 4,59Pc_1429 Sh3 domain-containing protein 4,59Pc_4825 Hypothetical protein trividraft_206391 4,59Pc_11711 --- n/a --- 4,58Pc_1034 Sulfate adenylyltransferase 4,58Pc_10855 3-oxoadipate enol-lactonase i 4,57Pc_4760 Hypothetical protein 4,56Pc_7650 Fad binding domain-containing protein 4,56Pc_1236 Snf1-related protein kinase catalytic subunit alpha kin11 4,56Pc_6515 Het domain-containing protein 4,56Pc_9461 C6 finger domain protein 4,56Pc_11703 --- n/a --- 4,55Pc_11066 --- n/a --- 4,55Pc_76 Nitrate assimilation regulatory protein nira 4,55Pc_3344 Nitrate assimilation regulatory protein nira 4,55Pc_665 Translation initiation factor 4,55Pc_2371 Proteasome component pre6 4,55Pc_8786 Conserved hypothetical protein 4,55Pc_7710 F-box protein 4,55Pc_6403 Histone acetylase complex subunit 4,54Pc_2582 Polyketide synthase 4,53Pc_7366 Fungal specific transcription 4,53Pc_5947 Hypothetical protein maa_02784 4,53Pc_10168 Amino acid 4,53Pc_5666 Hypothetical protein maa_07422 4,53Pc_9628 Bhlh family transcription factor 4,53

Pc_1110 Subtilisin-like protease 4,52Pc_9426 C6 transcription 4,52Pc_6600 Haloacid dehalogenase-like hydrolase 4,51Pc_2380 Protease s8 tripeptidyl peptidase 4,51Pc_6342 Homeobox and c2h2 transcription 4,51Pc_1755 Rna polymerase iii rpc4 4,50Pc_6951 Glycoside hydrolase family 3 protein 4,50Pc_2417 Pro40 protein 4,50Pc_10612 Abc1 family protein 4,50Pc_877 Thioredoxin-like protein 4,50Pc_2394 Proline-specific permease 4,50Pc_7014 Glycoside hydrolase 4,49Pc_165 Ankyrin repeat domain-containing protein 50 4,48Pc_4579 Integral membrane protein 4,48Pc_2460 Predicted protein 4,48Pc_5470 Hypothetical protein mac_01188 4,48Pc_9241 Calponin 4,47Pc_6931 Glycoside hydrolase family 43 protein 4,47Pc_6300 Hsp70-like protein 4,47Pc_532 Splicing factor spf30 4,46Pc_5351 Hypothetical protein mac_03166 4,46Pc_187 Wd domain-containing protein 4,46Pc_2184 Protein kinase-like domain 4,46Pc_9054 Cell morphogenesis protein pag1 4,45Pc_1102 Alkaline proteinase 4,45Pc_4903 Hypothetical protein snog_11853 4,45Pc_7451 Fluconazole resistance protein 4,44Pc_5772 Hypothetical protein maa_05522 4,44Pc_4799 Hypothetical protein trividraft_44495 4,43Pc_9404 C6 transcription 4,42Pc_6132 Hypothetical protein foxb_09304 4,42Pc_2888 Peroxisomal membrane anchor protein 4,42Pc_5773 Hypothetical protein maa_05521 4,42Pc_8550 Cytochrome p450 61 4,41Pc_6467 Hexose transport-related protein 4,41Pc_9924 Apaf1-interacting protein 4,40Pc_1256 Small s protein 4,40Pc_7083 Glutathione s-transferase 4,40Pc_5050 Hypothetical protein mac_08541 4,39Pc_3966 Mfs general substrate transporter 4,39Pc_7350 Fungal specific transcription factor domain protein 4,39Pc_3702 Mitogen activated protein kinase kinase 4,39Pc_2464 Predicted protein 4,38Pc_3279 Npc2-like protein 4,38Pc_6621 Guanyl-nucleotide exchange factor 4,38Pc_9462 C6 finger domain protein 4,38Pc_1596 Secreted protein 4,38Pc_9288 C6 zinc finger domain-containing protein 4,37Pc_3662 Morphogenesis protein 4,37Pc_8736 Cryptochrome dash 4,37Pc_753 Het domain-containing protein 4,35

Pc_7867 Er membrane protein 4,35Pc_3755 Mitochondrial import inner membrane translocase subunit tim-16 4,35Pc_10112 Amp dependent 4,35Pc_11486 --- n/a --- 4,35Pc_10778 50s ribosomal protein l1 4,35Pc_5981 Hypothetical protein maa_02221 4,35Pc_3241 Nuclear pore protein 4,34Pc_1840 Ribosome biogenesis protein 4,34Pc_10053 Ankyrin repeat protein 4,34Pc_2628 Plasma membrane fusion protein prm1 4,33Pc_4188 Maleylacetate reductase 4,33Pc_3745 Mitochondrial import receptor subunit 4,33Pc_4676 Inositol-pentakisphosphate 2-kinase 4,33Pc_2484 Pre-rrna processing nucleolar protein 4,33Pc_3925 Mfs multidrug 4,33Pc_2111 Protein-l-isoaspartate(d-aspartate) o-methyltransferase 4,32Pc_2374 Proteasome component pre2 precursor 4,32Pc_3096 Outer mitochondrial membrane protein porin 4,32Pc_9253 Calcium- spray protein 4,32Pc_2687 Phosphotransferase enzyme family protein 4,31Pc_11422 Glycosyl transferase 4,31Pc_339 Urb2 npa2 family protein 4,31Pc_5020 Hypothetical protein mac_09109 4,31Pc_9129 Catalase 4,30Pc_10661 Ab-hydrolase associated 4,30Pc_12117 --- n/a --- 4,29Pc_2112 Protein-l-isoaspartate(d-aspartate) o-methyltransferase 4,29Pc_1734 Rna-binding protein 4,29Pc_8297 Dna primase small subunit 4,29Pc_5168 Hypothetical protein mac_06302 4,29Pc_3781 Mitochondrial co-chaperone 4,29Pc_9651 Beta-lactamase domain-containing protein 4,29Pc_2549 Positive regulator of purine utilization 4,29Pc_8871 Cleavage factor two protein 1 4,29Pc_827 Protein 4,28Pc_5700 Hypothetical protein maa_06829 4,28Pc_8161 Domain-containing protein 4,28Pc_2035 Quinate permease 4,28Pc_7419 Fructose-bisphosphate aldolase 4,28Pc_3397 Ncs1 nucleoside transporter family protein 4,27Pc_5175 Hypothetical protein mac_06178 4,27Pc_8309 Dna polymerase delta catalytic subunit 4,27Pc_3599 Multispanning membrane 4,27Pc_5671 Hypothetical protein maa_07405 4,27Pc_9725 Atpase type 13a2 4,27Pc_9355 C6 transcription factor 4,26Pc_5163 Hypothetical protein mac_06360 4,26Pc_11096 Transposase-like protein 4,26Pc_6440 Hippurate hydrolase 4,26Pc_8303 Dna polymerase ii large subunit-like protein 4,26Pc_4700 Inner membrane magnesium transporter mrs2 4,26

Pc_9232 Candidate effector 14 4,26Pc_1659 Salicylate 4,25Pc_6014 Hypothetical protein maa_01703 4,25Pc_7539 Fe-containing alcohol 4,25Pc_11408 Hypothetical protein aspnidraft_53663 4,24Pc_4294 Lyr family protein 4,24Pc_4790 Hypothetical protein trividraft_61593 4,23Pc_7561 Fatty acid desaturase 4,23Pc_3903 Mfs multidrug transporter 4,23Pc_6361 Hit domain protein 4,23Pc_9356 C6 transcription factor 4,23Pc_9316 C6 zinc finger domain protein 4,22Pc_2949 Peptidase m61 domain-containing protein 4,22Pc_6964 Glycoside hydrolase family 20 protein 4,22Pc_7810 Eukaryotic translation initiation factor 3 subunit m 4,21Pc_4785 Hypothetical protein trividraft_68151 4,21Pc_11753 --- n/a --- 4,20Pc_5604 Hypothetical protein maa_09020 4,20Pc_4848 Hypothetical protein triatdraft_91646 4,20Pc_4914 Hypothetical protein ptt_08162 4,20Pc_3356 Nicotinamide n-methyltransferase 4,20Pc_8849 Cofilin tropomyosin-type actin-binding protein 4,20Pc_106 Xpg i-region protein 4,20Pc_9248 Calcium-transporting atpase 3 4,19Pc_6290 Hydantoinase 4,19Pc_1414 Short chain dehydrogenase family protein 4,19Pc_7283 G-protein beta subunit 4,19Pc_6905 Glycoside hydrolase family 63 protein 4,19Pc_6813 Glycosyltransferase family 22 protein 4,18Pc_6531 Het domain protein 4,18Pc_6908 Glycoside hydrolase family 55 protein 4,18Pc_8507 Cytosolic cu zn superoxide dismutase 4,18Pc_1527 Serine threonine protein kinase 4,18Pc_5412 Hypothetical protein mac_02094 4,17Pc_7663 Fad binding domain-containing protein 4,16Pc_7211 General alpha-glucoside permease 4,16Pc_7703 F1f0 atp synthase assembly protein 4,16Pc_1952 Sialidase-like protein 4,16Pc_8099 Duf1715 domain-containing protein 4,15Pc_699 Transcriptional coactivator p15 family protein 4,15Pc_6508 Het-e 4,15Pc_5786 Hypothetical protein maa_05324 4,14Pc_1883 Ribonuclease subunit b 4,14Pc_1140 Sterigmatocystin 8-o-methyltransferase 4,14Pc_9285 C6 zinc finger protein 4,14Pc_7401 Fumarylacetoacetate hydrolase 4,13Pc_2553 Porphobilinogen deaminase 4,13Pc_8837 Condensin complex subunit 1 4,13Pc_3995 Mevalonate kinase 4,13Pc_1550 Serine family 4,12Pc_5045 Hypothetical protein mac_08698 4,12

Pc_1078 Succinyl- ligase 4,11Pc_9680 Beta (1-3) glucanosyltransferase 4,11Pc_2668 Phosphotransferase family protein 4,11Pc_8382 Dihydrouridine synthase 4,11Pc_268 Vacuolar protein sorting-associated protein 4,10Pc_1025 Sulfate transporter 4,10Pc_8508 Cytoskeleton-associated protein 4,09Pc_5318 Hypothetical protein mac_03749 4,09Pc_8179 Domain-containing protein 4,09Pc_2214 Protein kinase 4,09Pc_1384 Short-chain dehydrogenases protein 4,09Pc_10191 Amidohydrolase 4,09Pc_5924 Hypothetical protein maa_03067 4,08Pc_2651 Phytanoyl- dioxygenase family protein 4,08Pc_6642 Gtpase activating protein 4,08Pc_772 Transcription factor 4,08Pc_10462 Acylase acy 1 4,08Pc_2418 Prib protein 4,08Pc_7732 F-box domain protein 4,07Pc_10626 Abc transporter 4,07Pc_7269 G1 s-specific cyclin pas1 4,07Pc_3612 Multidrug resistance protein fnx1 4,07Pc_5084 Hypothetical protein mac_07683 4,07Pc_9280 Cactin, putative 4,06Pc_11256 Hypothetical protein mac_07988 4,06Pc_11072 Uncharacterized protein cpur_00726 4,06Pc_6111 Hypothetical protein foxb_15367 4,06Pc_3067 P protein 4,06Pc_6457 Hexose transporter protein 4,06Pc_4567 Intermembrane space import and assembly protein 40 4,06Pc_9337 C6 zinc finger domain containing protein 4,06Pc_2259 Protein 4,06Pc_4708 Indoleamine -dioxygenase-like protein 4,06Pc_3762 Mitochondrial folate carrier protein 4,06Pc_8457 Deah-box rna helicase 4,06Pc_6605 Had-superfamily subfamily cecr5 4,06Pc_6739 Gnat family 4,05Pc_1568 Septum-promoting gtp-binding protein 1 4,05Pc_6803 Glycosyltransferase family 31 protein 4,05Pc_2757 Phosphoglycerate mutase 4,05Pc_9740 Atp-dependent rna helicase mrh-4 4,04Pc_408 Ubx domain protein 4,04Pc_10147 Amino acid transporter 4,04Pc_2315 Protein 4,04Pc_11499 --- n/a --- 4,04Pc_10118 Aminotransferase family protein 4,04Pc_1992 Ras-like gtp-binding 4,04Pc_7314 Fungal transcriptional regulatory protein 4,03Pc_245 Valyl-trna synthetase 4,02Pc_969 Tafazzin-like protein 4,02Pc_4185 Malic acid transport protein 4,02

Pc_7340 Fungal specific transcription factor domain-containing protein 4,02Pc_9591 Brct domain-containing protein 4,02Pc_10663 Aaa family atpase-like protein 4,01Pc_2923 Peptidyl-prolyl cis-trans isomerase e 4,01Pc_9478 C6 finger domain 4,01Pc_3849 Mfs transporter 4,00Pc_510 U1 small nuclear ribonucleoprotein 4,00Pc_3112 Origin recognition complex subunit 4 4,00Pc_3274 Nrps-like enzyme 4,00Pc_4559 Intramembrane protease 3,99Pc_9610 Biotin protein ligase 3,99Pc_3508 Nad dependent epimerase 3,99Pc_4707 Infection structure specific protein 3,99Pc_9713 Autophagy- protein 2 3,99Pc_9528 C2h2 finger domain 3,99Pc_1877 Ribose 5-phosphate isomerase 3,99Pc_570 Trna isopentenyltransferase 3,99Pc_3768 Mitochondrial dna helicase 3,98Pc_3790 Mitochondrial carrier protein 3,97Pc_8416 Dicarboxylate carrier protein 3,97Pc_6622 Guanyl-nucleotide exchange factor 3,97Pc_4013 Methyltransferase domain-containing protein 3,97Pc_9502 C2h2 transcription factor swi5 3,97Pc_7638 Fad dependent oxidoreductase 3,97Pc_10260 Alpha- - subfamily 3,97Pc_7740 F-box domain containing protein 3,96Pc_2485 Pre-mrna-splicing factor spp2 3,96Pc_6409 Histidine phosphotransferase hpt1p 3,96Pc_1588 Secreted protein nis1 3,96Pc_7626 Fad dependent oxidoreductase superfamily 3,96Pc_2027 R3h domain-containing protein 3,95Pc_6745 Gmp synthase 3,95Pc_2446 Predicted protein 3,95Pc_6643 Gtpase activating protein 3,95Pc_1037 Sulfatase domain protein 3,95Pc_5202 Hypothetical protein mac_05746 3,95Pc_9682 Berberine bridge enzyme 3,95Pc_5293 Hypothetical protein mac_04231 3,94Pc_10452 Adenosine deaminase 3,94Pc_6862 Glycosyl 3,94Pc_10695 80 kd mcm3-associated protein 3,93Pc_8168 Domain-containing protein 3,93Pc_4441 Kinetochore protein 3,93Pc_9987 Ankyrin repeat-containing 3,93Pc_4576 Integral membrane protein duf6 3,93Pc_6834 Glycosyl transferase family protein 3,93Pc_7865 Er membrane protein 3,93Pc_869 Thiosulfate sulfurtransferase 3,93Pc_10683 Pc21g03220 3,92Pc_6334 Homoaconitase precursor 3,92Pc_10644 Abc multidrug transporter 3,91

Pc_11477 50s ribosomal protein 3,91Pc_11603 --- n/a --- 3,91Pc_4309 Longevity-assurance protein 3,89Pc_907 Nudix domain-containing protein 3,88Pc_4425 Kynurenine-oxoglutarate transaminase 3,88Pc_216 Mfs general substrate transporter 3,88Pc_6913 Glycoside hydrolase family 55 protein 3,87Pc_4394 L-threo-3-deoxy-hexulosonate aldolase 3,87Pc_6234 Hypothetical protein aor_1_478084 3,87Pc_8962 Chitin synthase export chaperone 3,87Pc_7398 Fumarylacetoacetate hydrolase domain-containing protein 3,87Pc_2444 Predicted protein 3,87Pc_200 Vps9 domain protein 3,87Pc_3767 Mitochondrial dna replication protein 3,86Pc_10669 Aaa family 3,86Pc_610 Trfa protein 3,86Pc_2448 Predicted protein 3,86Pc_412 Ubiquitin-protein ligase sel1 3,86Pc_5455 Hypothetical protein mac_01461 3,86Pc_123 Wsc domain-containing protein 3,86Pc_1556 Ser thr protein phosphatase superfamily 3,85Pc_7355 Fungal specific transcription factor 3,85Pc_4094 Mercuric reductase 3,84Pc_10883 3-hydroxyisobutyryl- hydrolase 3,84Pc_4747 Ibr domain-containing protein 3,84Pc_3853 Mfs transporter 3,84Pc_4814 Hypothetical protein trividraft_220113 3,84Pc_1776 Rna exonuclease 4 3,84Pc_11208 Hypothetical protein trividraft_62228 3,84Pc_6685 Gpi mannosyltransferase 3,84Pc_1346 Short-chain dehydrogenase reductase family 3,84Pc_9267 Calcium calmodulin-dependent protein kinase 3,83Pc_7852 Essential subunit of the histone deacetylase rpd3s complex 3,83Pc_10358 Aldehyde dehydrogenase 3,83Pc_10975 2-dehydropantoate 2-reductase 3,82Pc_1969 Related to amidohydrolase 3,82Pc_474 Ubiquitin carboxyl-terminal hydrolase 3,82Pc_6123 Hypothetical protein foxb_11857 3,82Pc_5062 Hypothetical protein mac_08159 3,81Pc_5637 Hypothetical protein maa_08373 3,81Pc_4466 Kinase-like protein 3,81Pc_6097 Hypothetical protein ucrel1_4726 3,81Pc_6270 Hypothetical conserved protein 3,81Pc_11235 Hypothetical protein mysti_05978 3,81Pc_3180 Nudix hydrolase 14 3,80Pc_7985 E3 ubiquitin-protein ligase ubr1 3,80Pc_563 Trna pseudouridine synthase b 3,80Pc_788 30s ribosomal protein s17p-like protein 3,79Pc_3618 Multidrug resistance protein 1 3,79Pc_7289 G-patch domain 3,79Pc_11266 Hypothetical protein mac_05364 3,79

Pc_9921 Aquaporin 3,79Pc_2976 Pep2-like protein 3,79Pc_1164 Wd domain-containing protein 3,79Pc_4370 Lcl2_nech7 ame: full=long chronological lifespan protein 2 flags: precursor 3,79Pc_8253 Dna replication regulator sld2 3,79Pc_5105 Hypothetical protein mac_07270 3,78Pc_11411 Hypothetical protein aol_s00006g525 3,78Pc_1410 Short chain dehydrogenase reductase 3,78Pc_4781 Hypothetical protein trividraft_77131 3,78Pc_7241 Gamma-tubulin complex component 3,77Pc_9802 Atp dependent rna helicase 3,77Pc_8694 Cyanate lyase 3,77Pc_3181 Nudix family protein 3,77Pc_6678 Gpi-anchored wall transfer protein 1 3,77Pc_496 U3 snornp protein 3,77Pc_6054 Hypothetical protein maa_00751 3,77Pc_2804 Phosphatase family protein 3,77Pc_786 Tpr domain-containing protein 3,75Pc_321 Uridylate kinase 3,75Pc_9956 Ankyrin unc44 3,75Pc_2662 Phthalate transporter 3,75Pc_2542 Potassium ion channel yvc1 3,75Pc_10990 116 kda u5 small nuclear ribonucleoprotein component 3,75Pc_10619 Abc transporter family protein 3,75Pc_304 Vacuolar atp synthase 16 kda proteolipid subunit 2 3,74Pc_6928 Glycoside hydrolase family 47 protein 3,74Pc_5203 Hypothetical protein mac_05742 3,73Pc_1079 Succinyl- :3-ketoacid-coenzyme a transferase subunit a 3,73Pc_2826 Phenazine biosynthesis protein family 3,72Pc_3286 Nonsense-mediated mrna decay factor 3,72Pc_7483 Flavin-binding monooxygenase 3,72Pc_8821 Conserved hypothetical protein 3,72Pc_1251 Smn family protein smn1 3,72Pc_4735 Immunogenic protein 3,72Pc_3971 Mfs drug 3,72Pc_11980 --- n/a --- 3,72Pc_723 Transcription initiation factor iif subunit alpha 3,71Pc_10329 Alkaline phosphatase 3,71Pc_7178 Glucan -beta-glucosidase 3,71Pc_2586 Polyketide synthase 3,71Pc_5952 Hypothetical protein maa_02670 3,71Pc_9667 Beta- -glucanosyltransferase 3,70Pc_1799 Ring-finger protein 3,70Pc_4151 Mate efflux family protein 3,70Pc_1572 Secretory phospholipase a2 3,70Pc_9473 C6 finger domain 3,70Pc_6935 Glycoside hydrolase family 35 protein 3,70Pc_8874 Clc voltage-gated chloride channel 3,69Pc_6352 Hlh transcription 3,69Pc_6762 Glyoxalase bleomycin resistance protein dioxygenase 3,69Pc_10318 Allantoate permease 3,68

Pc_9805 Atp dependent dna ligase domain protein 3,68Pc_6260 Hypothetical protein acpl_3829 3,68Pc_10137 Amino-acid transporter arg-13 3,68Pc_791 Tpr domain protein 3,68Pc_2519 Pre-mrna polyadenylation factor fip1 3,68Pc_1083 Succinate-semialdehyde dehydrogenase 3,68Pc_1220 Sodium calcium exchanger protein 3,67Pc_3340 Nitrate reductase 3,67Pc_8584 Cytochrome p450 3,67Pc_9376 C6 transcription factor 3,66Pc_6219 Hypothetical protein ccm_03241 3,65Pc_10306 Allantoate permease of the major facilitator superfamily 3,65Pc_11615 --- n/a --- 3,65Pc_11607 --- n/a --- 3,65Pc_8435 Deoxyhypusine synthase 3,65Pc_4222 Major facilitator superfamily transporter 3,65Pc_7769 Extracellular elastinolytic metalloproteinase 3,65Pc_2296 Protein 3,64Pc_6364 Histone-lysine n-methyltransferase 3,64Pc_57 Zinc finger protein odd-paired-like 3,64Pc_3659 Mosc domain-containing protein 3,64Pc_4672 Integral membrane 3,64Pc_8842 Com1 regulatory protein 3,64Pc_6065 Hypothetical protein maa_00496 3,63Pc_7421 Fructose- -bisphosphatase 3,63Pc_8638 Cytidine and deoxycytidylate deaminase 3,63Pc_4713 Indoleamine -dioxygenase family protein 3,62Pc_4487 Ketol-acid reductoisomerase 3,62Pc_338 Urea active transporter 3,62Pc_9997 Ankyrin repeat-containing 3,61Pc_6751 Glyoxalase family protein 3,61Pc_5211 Hypothetical protein mac_05606 3,61Pc_1880 Ribonucleoside-diphosphate reductase large chain 3,61Pc_9776 Atp-citrate synthase subunit 1 3,61Pc_9958 Ankyrin unc44 3,60Pc_115 Xaa-pro dipeptidase 3,60Pc_4125 Mei5 protein 3,60Pc_5341 Hypothetical protein mac_03320 3,59Pc_2895 Peroxisomal copper amine oxidase 3,59Pc_9880 Aromatic-l-amino-acid decarboxylase 3,59Pc_10405 Aig2-like protein 3,59Pc_9428 C6 transcription 3,58Pc_7306 Fungal transcriptional regulatory protein 3,57Pc_8058 Duf455 domain protein 3,57Pc_5546 Hypothetical protein maa_10386 3,57Pc_11200 Hypothetical protein ucrel1_8694 3,57Pc_3285 Nonsense-mediated mrna decay protein 3,56Pc_1070 Hexose transporter 2 3,56Pc_8024 Duf833 domain-containing protein 3,56Pc_8496 D-arabinono- -lactone oxidase 3,55Pc_704 Transcriptional activator protein acu-15 3,54

Pc_10577 Acetyl- acetyltransferase 3,54Pc_5983 Hypothetical protein maa_02190 3,54Pc_3763 Mitochondrial export translocase oxa2 3,53Pc_1507 Serine threonine-protein kinase bur-1 3,53Pc_6284 Hydrophobic surface binding protein a 3,53Pc_8738 Cro1 protein 3,52Pc_4093 Mercuric reductase 3,52Pc_8178 Domain-containing protein 3,51Pc_9110 Cation transport atpase 3,51Pc_1233 Snf2 family helicase 3,51Pc_854 Threonyl-trna synthetase 3,51Pc_8216 Dnaj domain containing protein 3,51Pc_7248 Galacturan -alpha-galacturonidase b 3,51Pc_9056 Cell lysis protein 3,51Pc_6787 Glycosyltransferase family 4 protein 3,50Pc_9432 C6 transcription 3,49Pc_6662 Gtp-binding protein 3,49Pc_3669 Monocarboxylate permease 3,49Pc_262 Vacuolar protein sorting-associated protein 74 3,49Pc_2069 Pyridoxal kinase 3,49Pc_11579 --- n/a --- 3,49Pc_8730 Ctr copper transporter 3,49Pc_6456 Hexose transporter-like protein 3,48Pc_8460 Dead deah box helicase 3,48Pc_4744 Idc1 protein 3,48Pc_8685 Cyclin-dependent kinase 3,48Pc_8809 Conserved hypothetical protein 3,48Pc_173 Wd repeat protein 3,47Pc_790 30s ribosomal protein s17p-like protein 3,47Pc_11049 --- n/a --- 3,47Pc_4360 Leucine carboxyl methyltransferase 3,47Pc_112 Xaa-pro dipeptidase app 3,47Pc_336 Urea carboxylase 3,47Pc_6985 Glycoside hydrolase family 18 protein 3,46Pc_7552 Fatty acid hydroxylase superfamily protein 3,46Pc_322 Uridine nucleosidase 3,46Pc_5523 Hypothetical protein mac_00277 3,45Pc_72 Zinc finger domain-containing ccch-type 3,45Pc_4615 Integral membrane protein 3,45Pc_10388 Alcohol dehydrogenase 3,45Pc_1922 Rho gtpase activator 3,44Pc_10920 3 (2 ) -bisphosphate nucleotidase 3,44Pc_1800 Ring-finger domain containing protein 3,44Pc_522 Tyrosine phosphatase 3,44Pc_9476 C6 finger domain 3,43Pc_1354 Short-chain dehydrogenase reductase family 3,43Pc_2180 Protein kinase-like domain 3,43Pc_2095 Pth11-type gpcr protein 3,43Pc_5389 Hypothetical protein mac_02442 3,42Pc_3793 Mitochondrial carrier protein 3,41Pc_767 Transcription factor 3,41

Pc_6368 Histone-lysine n-methyltransferase 3,41Pc_6210 Hypothetical protein ccm_06313 3,41Pc_6790 Glycosyltransferase family 39 protein 3,41Pc_4558 Intron-binding protein aquarius 3,40Pc_5792 Hypothetical protein maa_05176 3,40Pc_10378 Alcohol dehydrogenase -like domain-containing protein 3,40Pc_8815 Conserved hypothetical protein 3,40Pc_2803 Phosphatase family protein 3,40Pc_4618 Integral membrane protein 3,40Pc_8286 Dna repair protein 3,39Pc_5501 Hypothetical protein mac_00566 3,38Pc_222 Viral a-type inclusion protein repeat domain-containing protein 3,38Pc_4888 Hypothetical protein thite_2109529 3,38Pc_3081 Oxidoreductase family protein 3,38Pc_11511 --- n/a --- 3,38Pc_1826 Rieske domain-containing protein 3,37Pc_180 Wd repeat containing protein pop1 3,37Pc_5371 Hypothetical protein mac_02751 3,37Pc_3047 Pab-dependent poly -specific ribonuclease subunit pan2 3,35Pc_5944 Hypothetical protein maa_02802 3,35Pc_3607 Multidrug transporter 3,35Pc_4705 Initiation-specific alpha- -mannosyltransferase 3,35Pc_7658 Fad binding domain-containing protein 3,35Pc_8889 Class 3 3,35Pc_4862 Hypothetical protein triatdraft_316693 3,34Pc_9729 Atp12 atpase family protein 3,34Pc_3468 Nadh-ubiquinone oxidoreductase 3,34Pc_1920 Rho gtpase rho1 3,34Pc_1968 Related to aro8-aromatic amino acid aminotransferase i 3,31Pc_9559 Bzip transcription factor 3,31Pc_6481 Heterokaryon incompatibility protein 3,31Pc_8442 Delta-1-pyrroline-5-carboxylate dehydrogenase 3,31Pc_10700 60s ribosome subunit biogenesis protein nip7 3,30Pc_7973 Ef-hand superfamily ca2+-modulated protein 3,30Pc_6595 Hc-toxin synthetase 3,29Pc_6528 Het domain protein 3,29Pc_9212 Carbohydrate-binding module family 21 protein 3,29Pc_9036 Cell wall glucanase 3,29Pc_4285 Lysosomal cystine transporter 3,29Pc_6770 Glycosyltransferase family 90 protein 3,29Pc_10657 Abc bile acid 3,29Pc_4173 Mannan polymerase complexes mnn9 subunit 3,28Pc_7308 Fungal transcriptional regulatory protein 3,28Pc_6057 Hypothetical protein maa_00720 3,28Pc_1967 Related to csi2 protein 3,27Pc_8665 Cyclopropane-fatty-acyl-phospholipid synthase 3,27Pc_6559 Helicase swr1 3,27Pc_4456 Kinesin light 3,26Pc_9873 Arrestin 3,26Pc_6822 Glycosyltransferase family 2 protein 3,26Pc_8862 Coagulation factor 5 8 type domain-containing protein 3,26

Pc_9640 Beta-lactamase family protein 3,26Pc_2802 Phosphate permease 3,25Pc_7300 Fungal zn binuclear cluster domain containing protein 3,25Pc_4887 Hypothetical protein thite_2111175 3,25Pc_9196 Carboxyl-terminal proteinase 3,25Pc_2987 Pentafunctional arom polypeptide 3,24Pc_571 Rna methylase family protein 3,24Pc_5920 Hypothetical protein maa_03149 3,24Pc_6644 Gtpase activating protein 3,24Pc_5996 Hypothetical protein maa_01969 3,24Pc_9839 Asparaginyl-trna synthetase 3,24Pc_1943 Repressible alkaline phosphatase precursor 3,24Pc_6946 Glycoside hydrolase family 3 protein 3,23Pc_2269 Tat pathway signal sequence 3,23Pc_11360 Hypothetical protein maa_01379 3,21Pc_8501 D-3-phosphoglycerate dehydrogenase 3,21Pc_3382 Negative regulation of gluconeogenesis 3,21Pc_5456 Hypothetical protein mac_01434 3,21Pc_8280 Dna repair protein rad16 3,21Pc_119 X-pro dipeptidyl- 3,21Pc_9857 Aryl-alcohol dehydrogenase 3,21Pc_4026 Methylitaconate delta2-delta3-isomerase 3,21Pc_792 Tpr domain protein 3,21Pc_10513 Actin-like protein 3,21Pc_8906 Chromosome segregation protein 3,20Pc_8784 Conserved leucine-rich repeat protein 3,20Pc_8857 Coatomer subunit 3,20Pc_11905 --- n/a --- 3,20Pc_5252 Hypothetical protein mac_04923 3,20Pc_2740 Phosphoinositide 3-phosphate phosphatase 3,20Pc_5519 Hypothetical protein mac_00319 3,20Pc_9932 Ap-1-like protein 3,20Pc_11078 Augustus_masked-scaffold373-abinit-gene- -mrna-1 3,19Pc_11421 Gnat family 3,19Pc_1391 Short chain dehydrogenase reductase family protein 3,19Pc_1663 Saccharopine dehydrogenase 3,19Pc_8357 Dipeptidyl peptidase 3,19Pc_1622 Scf e3 ubiquitin ligase complex f-box protein grra 3,18Pc_8232 Dna-directed rna polymerase iii 130 kda polypeptide 3,18Pc_7518 Feruloyl esterase 3,18Pc_1437 Sexual differentiation process protein 3,18Pc_2523 Pqq enzyme repeat protein 3,18Pc_1661 Saga complex subunit sgf29 3,18Pc_10225 Alpha-n- 3,18Pc_9410 C6 transcription 3,17Pc_2191 Protein kinase-like domain 3,17Pc_9654 Beta-lactamase 3,17Pc_8029 Duf803 domain membrane protein 3,17Pc_5281 Hypothetical protein mac_04336 3,16Pc_7530 Ferric reductase like transmembrane component 3,16Pc_4651 Integral membrane protein 3,16

Pc_10647 Abc multidrug 3,16Pc_8198 Domain containing protein 3,16Pc_719 Transcription initiation factor tfiid subunit 11 3,15Pc_11796 --- n/a --- 3,15Pc_3019 Papa-1-like conserved region family protein 3,15Pc_10731 60s ribosomal protein l19 3,15Pc_7210 General amidase 3,14Pc_9386 C6 transcription 3,14Pc_868 Cytoplasmic trna 2-thiolation protein 2 3,14Pc_5112 Repetitive proline-rich cell wall protein 3,14Pc_5676 Hypothetical protein maa_07315 3,13Pc_2365 Proteasome regulatory particle subunit rpt4 3,13Pc_177 Wd repeat domain-containing protein 3,12Pc_3879 Mfs transporter 3,12Pc_2984 Pentatricopeptide repeat domain-containing protein 3,12Pc_1509 Serine threonine-protein kinase 3,12Pc_9677 Beta tubulin 3,12Pc_1524 Serine threonine protein kinase 3,12Pc_12061 --- n/a --- 3,12Pc_5993 Hypothetical protein maa_01983 3,11Pc_2931 Peptidyl-arginine deiminase domain protein 3,11Pc_6681 Gpi-anchor transamidase precursor 3,10Pc_4839 Hypothetical protein trividraft_140693 3,10Pc_12095 --- n/a --- 3,10Pc_3875 Mfs transporter 3,10Pc_8926 Chorismate synthase 3,09Pc_9918 Arb2 domain-containing protein 3,09Pc_3360 Nhl repeat-containing protein 3,09Pc_9870 Arrestin domain containing protein 3,09Pc_5136 Hypothetical protein mac_06795 3,08Pc_10093 And nb-arc domain protein 3,08Pc_7003 Glycoside hydrolase 3,08Pc_811 Tpa: zn 2cys6 transcription factor 3,08Pc_2919 Peptidyl-trna hydrolase 3,08Pc_3970 Mfs drug efflux 3,08Pc_5046 Hypothetical protein mac_08697 3,08Pc_8003 Dynamin central region 3,08Pc_2615 Pol-like protein 3,07Pc_1692 Rta1 domain protein 3,07Pc_11327 Hypothetical protein maa_06952 3,07Pc_8847 Coiled-coil domain-containing protein 3,07Pc_288 Vacuolar fusion protein mon1 3,06Pc_399 Udp-galactose transporter like protein 3,06Pc_8057 Duf455 domain-containing protein 3,05Pc_2437 Predicted protein 3,05Pc_2546 Potassium 3,05Pc_11996 --- n/a --- 3,05Pc_1113 -like protein 3,05Pc_5078 Hypothetical protein mac_07763 3,05Pc_2679 Phosphotransferase enzyme family protein 3,04Pc_4335 Lipase 1 3,03

Pc_5306 Hypothetical protein mac_03950 3,03Pc_3256 Nuclear fusion protein 3,03Pc_1964 Related to glucose dehydrogenase 3,03Pc_10591 Acetoacetate- ligase 3,02Pc_10422 Af323581_1beta transducin-like protein het-e4s 3,02Pc_6485 Heterokaryon incompatibility protein 3,02Pc_10739 60s ribosomal protein l15 3,01Pc_7755 Extracellular serine-rich protein 3,01Pc_10519 Actin lateral binding protein 3,01Pc_1054 General substrate transporter 3,01Pc_12094 --- n/a --- 3,01Pc_1143 Start control protein cdc10 3,00Pc_6865 Alpha-l-fucosidase 2 3,00Pc_4084 Metal-dependent amidase aminoacylase carboxypeptidase 3,00Pc_11181 Metal dependent phosphohydrolase 2,99Pc_11475 Pc13g00910 2,99Pc_8366 Dimethylaniline monooxygenase 2,99Pc_5977 Hypothetical protein maa_02316 2,99Pc_486 Ubid family decarboxylase 2,99Pc_2773 Phosphatidylserine decarboxylase family protein 2,99Pc_2206 Protein kinase domain protein 2,99Pc_1115 Structural maintenance of chromosome complex subunit 2,99Pc_7310 Fungal transcriptional regulatory protein 2,99Pc_8899 Citrate binding protein 2,98Pc_5337 Hypothetical protein mac_03398 2,98Pc_8939 Choline transport 2,98Pc_1780 Rna binding protein 2,98Pc_5682 Hypothetical protein maa_07125 2,97Pc_3320 Nitroreductase family protein 2,97Pc_4532 Isochorismatase family protein 2,97Pc_8090 Duf1769-domain-containing protein 2,96Pc_8709 Curved dna-binding protein 2,95Pc_5440 Hypothetical protein mac_01668 2,95Pc_3246 Nuclear pore complex subunit 2,95Pc_10243 Alpha-galactosidase 2,94Pc_8541 Cytochrome p450 alkane 2,94Pc_7177 Glucan endo- -alpha-glucosidase agn1 2,93Pc_6906 Glycoside hydrolase family 63 2,93Pc_9497 C2h2 type zinc finger domain protein 2,93Pc_5838 Hypothetical protein maa_04416 2,92Pc_9676 Beta- 2,92Pc_4307 Lovastatin nonaketide synthase 2,92Pc_2186 Protein kinase-like domain 2,92Pc_2185 Protein kinase-like domain 2,92Pc_10087 Ankyrin and het domain protein 2,91Pc_4533 Isochorismatase family protein 2,91Pc_9289 C6 zinc finger domain-containing protein 2,91Pc_174 Wd repeat protein 2,91Pc_5541 Hypothetical protein mac_00030 2,90Pc_6995 Glycoside hydrolase family 16 protein 2,90Pc_10249 Alpha- sarcomeric (f-actin cross linking protein) 2,90

Pc_5852 Hypothetical protein maa_04244 2,90Pc_3374 Neutral alpha-glucosidase ab precursor 2,90Pc_5625 Hypothetical protein maa_08669 2,90Pc_10492 Acyl- dehydrogenase 2,90Pc_9699 Bar adaptor protein 2,89Pc_9615 Binuclear zinc transcription factor 2,89Pc_7182 Gleya adhesin domain 2,89Pc_9579 Btb poz domain-containing protein 2,88Pc_1476 Serine threonine-protein phosphatase 2a activator 2 2,87Pc_9307 C6 zinc finger domain protein 2,87Pc_8987 Cfem domain-containing protein 2,87Pc_5904 Hypothetical protein maa_03445 2,87Pc_4866 Hypothetical protein triatdraft_300736 2,86Pc_11799 --- n/a --- 2,85Pc_11321 Hypothetical protein maa_07339 2,85Pc_8021 Duf858 domain-containing protein 2,85Pc_8977 Chd5 domain-containing protein 2,85Pc_3965 Mfs gliotoxin efflux transporter 2,85Pc_3666 Monocarboxylate transporter 2,85Pc_9492 C2h2 type zinc finger domain-containing protein 2,85Pc_10208 Amidase family protein 2,85Pc_7073 Glutathione s-transferase 2,84Pc_9480 C6 finger domain 2,84Pc_5928 Hypothetical protein maa_03036 2,83Pc_590 Trimethyllysine dioxygenase 2,83Pc_11763 --- n/a --- 2,83Pc_3118 Opy2 protein 2,83Pc_9420 C6 transcription 2,82Pc_3596 Muscle-derived protein (neurite-outgrowth-promoting) 2,82Pc_3174 O-acetylhomoserine -lyase 2,82Pc_11474 Pc14g01250 2,82Pc_11195 Hypothetical protein vdag_04871 2,82Pc_157 Wd repeat-containing protein 2,81Pc_2825 Phenmedipham hydrolase 2,81Pc_5918 Hypothetical protein maa_03178 2,80Pc_8010 Duf914 domain membrane protein 2,80Pc_11626 --- n/a --- 2,79Pc_4871 Hypothetical protein triatdraft_286603 2,79Pc_2854 Ph domain protein 2,79Pc_6971 Glycoside hydrolase family 2 protein 2,79Pc_9366 C6 transcription factor 2,79Pc_9218 Carbohydrate binding family 6 2,78Pc_1811 Ring-12 protein 2,78Pc_11139 Protein 2,78Pc_5823 Hypothetical protein maa_04848 2,78Pc_2340 Protein 2,78Pc_360 Upf0075 domain protein 2,78Pc_11487 --- n/a --- 2,78Pc_1202 Sorbitol utilization protein sou2 2,76Pc_11468 Arrestin 2,76Pc_1644 Salicylate synthase 2,76

Pc_10133 Aminodeoxychorismate synthase 2,76Pc_9512 C2h2 transcription factor 2,76Pc_1983 Regulator of g protein signaling superfamily 2,75Pc_9739 Atp-dependent rna helicase mss116 2,75Pc_6843 Glycosyl hydrolase family 43 protein 2,75Pc_1447 Set domain-containing protein 2,75Pc_1249 Smr domain-containing protein 2,74Pc_4973 Hypothetical protein ncu07948 2,74Pc_10922 2og-fe oxygenase family oxidoreductase 2,74Pc_3017 Para-nitrobenzyl esterase 2,73Pc_10121 Aminotransferase 2,73Pc_8237 Dna-directed rna polymerase ii subunit rpb1 2,73Pc_4303 Low temperature requirement a protein 2,72Pc_5901 Hypothetical protein maa_03496 2,72Pc_9046 Cell surface metalloreductase 2,72Pc_124 Wsc domain-containing protein 2,72Pc_6672 Group protein 2,72Pc_11816 --- n/a --- 2,72Pc_10484 Acyl- dehydrogenase family member 11 2,72Pc_11367 Hypothetical protein gmdg_08448 2,72Pc_6126 Hypothetical protein foxb_10630 2,72Pc_11993 --- n/a --- 2,72Pc_3890 Mfs sugar 2,71Pc_10284 Alpha beta hydrolase family protein 2,70Pc_2367 Proteasome maturation factor 2,70Pc_195 Wd domain containing protein 2,70Pc_2048 Pyruvate dehydrogenase kinase 2,70Pc_2621 Plastidic glucose transporter 4 2,70Pc_9390 C6 transcription 2,70Pc_5192 Hypothetical protein mac_05908 2,70Pc_7376 Fungal specific transcription 2,70Pc_5290 Hypothetical protein mac_04276 2,69Pc_4405 L-galactonate dehydratase 2,69Pc_4778 Hypothetical protein tsta_013570 2,69Pc_9966 Ankyrin repeat-containing protein 2,69Pc_674 Transketolase 2,69Pc_11165 Peroxin 8 2,69Pc_7693 Fad binding 2,69Pc_11217 Hypothetical protein triatdraft_78918 2,69Pc_4445 Kinesin motor domain-containing protein 2,68Pc_11439 Dual specificity tyrosine-phosphorylation-regulated kinase 3 2,68Pc_8575 Cytochrome p450 2,68Pc_1816 Ring finger protein 2,68Pc_8446 Delta -sterol reductase 2,67Pc_10281 Alpha beta hydrolase fold family 2,67Pc_317 Uv excision repair protein 2,67Pc_3628 Mucoidy inhibitor-like protein 2,66Pc_2052 Pyruvate dehydrogenase 2,66Pc_10771 50s ribosomal protein l4 2,66Pc_6700 Golgi to endosome transport protein 2,65Pc_8604 Cytochrome p450 2,65

Pc_558 Trna-guanine transglycosylase family protein 2,65Pc_9866 Ars-binding protein 2,65Pc_5069 Hypothetical protein mac_07915 2,64Pc_182 Wd repeat containing protein 36 2,64Pc_4731 Import inner membrane translocase subunit tim-21 2,63Pc_7761 Extracellular protein 2,63Pc_9070 Cell division control protein 2,63Pc_6112 Hypothetical protein foxb_15200 2,62Pc_2698 Phosphoribulokinase uridine kinase family protein 2,62Pc_11184 Large subunit of -dimethylformamidase 2,62Pc_7974 Ef-hand superfamily ca2+-modulated protein 2,61Pc_5365 Hypothetical protein mac_02926 2,61Pc_6854 Glycosyl hydrolase 2,61Pc_9008 Cellobiohydrolase ii 2,61Pc_3105 Orotate phosphoribosyltransferase 2,61Pc_9660 Beta-galactosidase precursor 2,61Pc_8443 Delta(24(24 ))-sterol reductase 2,61Pc_5794 Hypothetical protein maa_05157 2,60Pc_7583 Family protein 2,60Pc_9370 C6 transcription factor 2,60Pc_4015 Methyltransferase domain-containing protein 2,60Pc_10218 Alternative sulfate transporter 2,60Pc_3306 Non-ribosomal peptide synthetase 2,59Pc_5410 Hypothetical protein mac_02097 2,59Pc_3852 Mfs transporter 2,59Pc_12108 --- n/a --- 2,59Pc_9672 Beta- - 2,59Pc_9134 Caspase-like protein 2,59Pc_2127 Protein sno4 2,59Pc_8160 Domain-containing protein 2,59Pc_7013 Glycoside hydrolase 2,59Pc_5029 Hypothetical protein mac_09044 2,58Pc_5575 Hypothetical protein maa_09603 2,58Pc_1514 Serine threonine protein kinase 2,58Pc_2661 Phthalate transporter 2,57Pc_4516 Isoleucyl-trna synthetase 2,57Pc_8177 Domain-containing protein 2,57Pc_8560 Cytochrome p450 2,57Pc_6552 Hemagglutinin-related protein 2,56Pc_2317 Protein 2,56Pc_9082 Cell cycle control protein 2,56Pc_3032 Palmitoyltransferase pfa4 2,56Pc_138 Wd repeat domain-containing protein 2,55Pc_9950 Ankyrin unc44 2,55Pc_11864 --- n/a --- 2,55Pc_8705 Cutinase g-box binding protein 2,55Pc_8782 Conserved mitochondrial protein 2,55Pc_3904 Mfs multidrug transporter 2,55Pc_1824 Ring finger domain 2,55Pc_5506 Hypothetical protein mac_00516 2,54Pc_1238 Snare domain-containing protein 2,54

Pc_7622 Fad linked oxidase domain protein 2,54Pc_2967 Peptidase caspase catalytic subunit p20 2,54Pc_999 Swi snf complex protein 2,53Pc_11791 --- n/a --- 2,53Pc_3855 Mfs transporter 2,53Pc_4697 Inner membrane transport protein yfav 2,53Pc_10622 Abc transporter cdr4 2,52Pc_3068 Oxysterol-binding protein 2,52Pc_5107 Hypothetical protein mac_07262 2,52Pc_6391 Histone chaperone 2,52Pc_7776 Extensin 2,51Pc_5630 Hypothetical protein maa_08501 2,51Pc_11095 Transposase-like protein 2,51Pc_6511 Het-domain-containing protein 2,51Pc_5081 Hypothetical protein mac_07735 2,51Pc_4217 Major facilitator superfamily transporter 2,51Pc_10923 2og-fe oxygenase family 2,51Pc_837 Tom1 protein 2,50Pc_1482 Serine threonine-protein kinase sgk2 2,50Pc_7079 Glutathione s-transferase 2,50Pc_7227 Gcn5-related n-acetyltransferase 2,50Pc_6612 H k atpase alpha 2,50Pc_7643 Fad dependent oxidoreductase 2,50Pc_8083 Duf218 domain-containing protein 2,50Pc_507 U1 snrnp-associated protein usp107 2,49Pc_7364 Fungal specific transcription 2,49Pc_6922 Glycoside hydrolase family 47 protein 2,49Pc_4940 Hypothetical protein nechadraft_88568 2,49Pc_4153 Mat1-2-1 2,48Pc_7763 Extracellular proline-serine rich protein 2,48Pc_8581 Cytochrome p450 2,48Pc_651 Translin-associated protein x 2,48Pc_207 Voltage-gated k+ channel beta subunit 2,48Pc_1987 Red-like protein 2,48Pc_11177 Mutator-like element 2,47Pc_6655 Gtp-binding protein guf1 2,47Pc_5070 Hypothetical protein mac_07904 2,47Pc_4723 Importin subunit beta-3 2,47Pc_6174 Hypothetical protein fg03099.1 2,47Pc_8673 Cyclin-related 2 2,47Pc_806 Tpa_inf: bifunctional dethiobiotin synthetase adenosylmethionine-8-amino- 2,46Pc_10289 Alpha beta hydrolase 2,46Pc_8774 Cop9 signalosome subunit 1 2,46Pc_10119 Aminotransferase class i and ii 2,46Pc_701 Transcriptional adaptor-like protein 2,46Pc_7906 Endosomal spry domain 2,45Pc_11484 --- n/a --- 2,45Pc_12002 --- n/a --- 2,45Pc_7232 Gata transcription factor 2,44Pc_6896 Glycoside hydrolase family 75 protein 2,44Pc_11590 --- n/a --- 2,44

Pc_8706 Cutinase 2,44Pc_5932 Hypothetical protein maa_02938 2,44Pc_2450 Predicted protein 2,43Pc_6943 Glycoside hydrolase family 3 protein 2,43Pc_7032 Glycerophosphodiester phosphodiesterase gde1 2,43Pc_1949 Related to tol protein 2,43Pc_475 Ubiquitin carboxyl-terminal family 1 2,43Pc_8483 D-xylulose 5-phosphate d-fructose 6-phosphate phosphoketolase 2,43Pc_7959 Egg shell protein 2,43Pc_937 Telomere length regulator protein 2,42Pc_6914 Glycoside hydrolase family 54 protein 2,42Pc_4836 Hypothetical protein trividraft_162615 2,42Pc_2813 Phenylalanyl-trna synthetase alpha chain 2,42Pc_1611 Sec34-like family protein 2,41Pc_10312 Allantoate permease 2,41Pc_1918 Rho guanyl nucleotide exchange factor 2,41Pc_7788 Exoglucanase type c precursor 2,41Pc_7455 Floculation protein flo1 2,41Pc_661 Translation initiation factor eif4e 2,40Pc_627 Transporter-like protein 2,40Pc_4907 Hypothetical protein snog_02043 2,40Pc_8119 Duf1275 domain protein 2,40Pc_5588 Hypothetical protein maa_09353 2,40Pc_235 Synaptobrevin 2,40Pc_190 Wd domain protein 2,39Pc_5183 Hypothetical protein mac_06084 2,39Pc_6805 Glycosyltransferase family 31 protein 2,39Pc_6149 Hypothetical protein foc4_g10003797 2,39Pc_3883 Mfs sugar transporter 2,38Pc_11815 --- n/a --- 2,38Pc_1059 Hexose carrier protein 2,38Pc_5074 Hypothetical protein mac_07863 2,38Pc_9531 C2h2 finger domain 2,38Pc_8538 Cytochrome p450 alkane hydroxylase 2,37Pc_11724 --- n/a --- 2,37Pc_8941 Choline transport 2,37Pc_4434 Kinetochore protein spc25 2,37Pc_4397 L-psp endoribonuclease family 2,37Pc_12070 --- n/a --- 2,37Pc_689 Transcriptional regulator 2,37Pc_6716 Gnat family acetyltransferase 2,36Pc_3361 Nfx1-type zinc finger-containing protein 1 2,36Pc_6911 Glycoside hydrolase family 55 protein 2,36Pc_10314 Allantoate permease 2,36Pc_5629 Hypothetical protein maa_08506 2,35Pc_8326 Dna ligase 2,35Pc_10871 3-ketoacyl-acyl carrier protein reductase 2,35Pc_1418 Short chain dehydrogenase 2,35Pc_7614 Fad-dependent monooxygenase 2,35Pc_6308 Hsp70 family 2,34Pc_10155 Amino acid permease 2,34

Pc_4383 Lactose permease 2,34Pc_6936 Glycoside hydrolase family 31 protein 2,34Pc_1382 Short chain type protein 2,33Pc_550 Trypsin-like protease 2,33Pc_5304 Hypothetical protein mac_03956 2,33Pc_11502 --- n/a --- 2,33Pc_315 Uv-endonuclease uve-1 2,33Pc_1263 Small nucleolar ribonucleoprotein complex subunit utp14 2,33Pc_6809 Glycosyltransferase family 31 protein 2,33Pc_6546 Hemerythrin hhe cation binding domain-containing protein 2,32Pc_710 Transcription regulator 2,32Pc_10734 60s ribosomal protein l19 2,32Pc_3025 Pantothenate transporter liz1 2,32Pc_3318 Nitrosoguanidine resistance protein sng1 2,32Pc_11839 --- n/a --- 2,32Pc_9143 Casein kinase i 2,31Pc_4994 Hypothetical protein mac_09758 2,31Pc_3764 Mitochondrial export translocase oxa1 2,30Pc_3593 Myb dna binding protein 2,30Pc_5623 Hypothetical protein maa_08714 2,30Pc_3585 Myb transcription factor 2,30Pc_9511 C2h2 transcription factor 2,30Pc_8595 Cytochrome p450 2,29Pc_548 Complement factor d-like 2,29Pc_10040 Ankyrin repeat protein 2,29Pc_4061 Metalloprotease 2,29Pc_5319 Hypothetical protein mac_03721 2,29Pc_8994 Cephalosporin esterase 2,29Pc_8355 Diphosphomevalonate decarboxylase 2,29Pc_9516 C2h2 finger domain-containing protein 2,29Pc_4357 Leucine rich repeat domain protein 2,29Pc_5881 Hypothetical protein maa_03907 2,29Pc_6912 Glycoside hydrolase family 55 protein 2,28Pc_7260 Gaba permease 2,28Pc_2131 Protein rho1 2,28Pc_514 Tyrosyl-dna phosphodiesterase domain-containing protein 2,28Pc_8048 Duf602 domain-containing protein 2,27Pc_3657 Mpr-like gpcr protein 2,27Pc_10414 Aflt aflt transmembrane protein 2,27Pc_1963 Related to glyoxal oxidase precursor 2,27Pc_1554 Serine 2,27Pc_1605 Secreted aspartic proteinase 2,27Pc_9879 Aromatic-l-amino-acid decarboxylase 2,26Pc_1028 Sulfate permease 2 2,26Pc_2504 Pre-mrna splicing factor syf1 2,26Pc_8801 Conserved hypothetical protein 2,26Pc_6980 Glycoside hydrolase family 18 protein 2,26Pc_4387 Lactose permease 2,25Pc_8647 Cysteine synthase 2,25Pc_10300 Allergen asp f7 2,25Pc_4684 Inositol monophosphatase 2,25

Pc_2747 Phosphoglycerate mutase family protein 2,24Pc_12109 --- n/a --- 2,24Pc_656 Translation machinery-associated protein 20 2,24Pc_4016 Methyltransferase - 2,24Pc_4123 Meiosis protein mei2 2,24Pc_7681 Fad binding domain protein 2,24Pc_3056 P60-like cell-wall 2,23Pc_3146 Oligopeptide transporter 2,23Pc_345 Uracil permease 2,23Pc_4420 L-amino-acid oxidase 2,23Pc_834 Topoisomerase ii-associated protein pat1 2,23Pc_4737 Imidazole glycerol phosphate synthase hishf 2,23Pc_10889 3-hydroxyisobutyrate dehydrogenase 2,23Pc_5736 Hypothetical protein maa_06112 2,22Pc_3690 Mmc protein 2,22Pc_3708 Mitochondrial s-adenosylmethionine transporter 2,22Pc_8269 Dna replication atpase 2,22Pc_9072 Cell differentiation protein rcd1 2,22Pc_7262 Gaba permease 2,22Pc_7353 Fungal specific transcription factor 2,22Pc_2395 Proline-specific permease 2,22Pc_6191 Hypothetical protein ch063_06390 2,22Pc_3601 Multiple epidermal growth factor-like domains protein 6-like 2,22Pc_3881 Mfs transporter 2,22Pc_3 Zz type zinc finger domain protein 2,22Pc_4182 Maltose permease 2,22Pc_7039 Glycerol-3-phosphate acyltransferase 2,21Pc_3283 Nonsense-mediated mrna decay protein 1 2,21Pc_8950 Choline dehydrogenase 2,21Pc_793 Tetratricopeptide tpr_4 protein 2,21Pc_5844 Hypothetical protein maa_04295 2,21Pc_12091 --- n/a --- 2,21Pc_5713 Hypothetical protein maa_06514 2,21Pc_3959 Mfs maltose permease 2,20Pc_8206 Dolichol kinase 2,20Pc_10173 Amino acid 2,20Pc_1365 Short-chain dehydrogenase protein 2,20Pc_5514 Hypothetical protein mac_00389 2,20Pc_2704 Phosphoribosylaminoimidazole carboxylase 2,20Pc_2379 Proteasome activator subunit 2,20Pc_4240 Major facilitator superfamily transporter 2,20Pc_9560 Bzip transcription factor 2,19Pc_12089 --- n/a --- 2,19Pc_9295 C6 zinc finger domain-containing protein 2,19Pc_1609 Sec7 domain-containing protein 2,19Pc_5612 Hypothetical protein maa_08894 2,18Pc_10337 Aldo-keto reductase 2,18Pc_5968 Hypothetical protein maa_02412 2,18Pc_3760 Mitochondrial genome maintenance protein mgm101 2,18Pc_10585 Acetolactate synthase 2,18Pc_9380 C6 transcription 2,18

Pc_7892 Enoyl- hydratase isomerase family protein 2,17Pc_5189 Hypothetical protein mac_05964 2,17Pc_5485 Hypothetical protein mac_00843 2,17Pc_8484 D-xylose-proton symporter 2,17Pc_4598 Integral membrane protein 2,16Pc_4673 Insig domain protein 2,16Pc_2287 Protein 2,16Pc_7845 Estradiol 17 beta- 2,16Pc_3969 Mfs drug efflux 2,16Pc_6306 Hsp70 family chaperone 2,16Pc_9844 Ash2-trithorax family protein 2,16Pc_8444 Delta(24(24 ))-sterol reductase 2,15Pc_7095 Glutaredoxin domain protein 2,15Pc_10586 Acetolactate synthase 2,15Pc_7244 Gamma-glutamyltranspeptidase 2,15Pc_3974 Mfs drug 2,14Pc_1385 Short chain oxidoreductase 2,14Pc_6981 Glycoside hydrolase family 18 protein 2,14Pc_437 Ubiquitin-conjugating enzyme 2,14Pc_8276 Dna repair protein rad5 2,13Pc_1882 Ribonuclease t2 2,13Pc_5695 Hypothetical protein maa_06951 2,12Pc_8860 Coatomer beta subunit 2,12Pc_7272 G-protein coupled receptor 2,12Pc_7801 Eukaryotic translation initiation factor subunit eif- 2,12Pc_2988 Penicillin-binding protein, putative 2,12Pc_10042 Ankyrin repeat protein 2,11Pc_5611 Hypothetical protein maa_08896 2,11Pc_8707 Cutinase 2,11Pc_1806 Ring-6 like protein 2,11Pc_1695 Rta1 domain 2,10Pc_7400 Fumarylacetoacetate hydrolase 2,10Pc_6363 Histone-lysine n-methyltransferase 2,10Pc_5951 Hypothetical protein maa_02688 2,09Pc_2377 Proteasome component c1 2,09Pc_7346 Fungal specific transcription factor domain-containing protein 2,09Pc_7173 Glucoamylase 2,09Pc_10587 Acetolactate synthase 2,09Pc_7562 Fatty acid desaturase 2,09Pc_2689 Phosphotransferase enzyme family domain protein 2,09Pc_3643 Mrna splicing protein 2,09Pc_10637 Abc transporter 2,09Pc_9807 Atp binding protein 2,08Pc_3012 Partial 2,08Pc_7368 Fungal specific transcription 2,08Pc_10171 Amino acid 2,08Pc_2823 Phenol 2- 2,08Pc_4081 Metallo-beta-lactamase domain 2,07Pc_2706 Phosphoprotein phosphatase 2,07Pc_4931 Hypothetical protein neute1draft_124927 2,07Pc_9554 Bzip transcription factor 2,07

Pc_7285 G-patch domain-containing protein 2,07Pc_10768 50s ribosomal subunit protein l15 2,07Pc_1344 Short chain dehydrogenase 2,07Pc_65 Zinc finger protein 2,06Pc_1317 Siderophore iron transporter 1 2,06Pc_9096 Ccch zinc finger domain-containing protein 2,06Pc_404 Ubx domain-containing protein 2,06Pc_4537 Isochorismatase family 2,06Pc_1564 Ser thr protein phosphatase 2,05Pc_10676 A g-specific adenine glycosylase 2,05Pc_930 Terpene synthase 2,05Pc_6071 Hypothetical protein maa_00301 2,04Pc_7532 Ferric reductase 2,04Pc_10524 Acriflavine sensitivity control protein acr-2 2,04Pc_1035 Sulfatase domain-containing protein 2,04Pc_8908 Chromosome segregation protein 2,04Pc_527 Type 2a phosphatase activator tip41 2,04Pc_5186 Hypothetical protein mac_06056 2,04Pc_7816 Eukaryotic translation initiation factor 3 subunit clu1 2,04Pc_2135 Protein rds1 2,03Pc_11135 Protein 2,03Pc_3253 Nuclear migration protein 2,02Pc_9648 Beta-lactamase domain-containing protein 2,01Pc_7255 Gag polymerase env 2,01Pc_2350 Protein 2,01Pc_6408 Histidinol-phosphatase 2,01Pc_9683 Benzoate 4-monooxygenase cytochrome p450 2,01Pc_3915 Mfs multidrug 2,01Pc_3266 Nuclear condensin complex subunit smc4 2,00Pc_761 Transcription factor 2,00Pc_1493 Serine threonine-protein kinase ppk6 2,00Pc_11315 Hypothetical protein maa_08738 2,00Pc_7567 Farnesyltransferase beta subunit ram1 2,00Pc_2120 Protein transport protein sec39 2,00Pc_828 5 -p- -4-tetraphosphate phosphorylase 2 1,99Pc_8990 Cfem domain-containing protein 1,99Pc_7033 Glycerol:h+ symporter 1,99Pc_2658 Phytanoyl- dioxygenase 1,99Pc_7991 Dyp-type peroxidase family 1,98Pc_2893 Peroxisomal dehydratase 1,98Pc_4682 Inositol oxygenase 1 1,98Pc_7352 Fungal specific transcription factor domain protein 1,98Pc_4869 Hypothetical protein triatdraft_291144 1,98Pc_4155 Mapkkk cascade protein kinase regulator ste50 1,98Pc_9954 Ankyrin unc44 1,97Pc_3402 Nb-arc and tpr domain protein 1,97Pc_196 Wasp-like pretein las17p 1,97Pc_7064 Glutathione s-transferase gst3 1,97Pc_4268 Mage family protein 1,97Pc_267 Vacuolar protein sorting-associated protein 1,97Pc_7920 Endonuclease exonuclease phosphatase family protein 1,96

Pc_2141 Protein phosphatase- 1,95Pc_8466 Deacetoxycephalosporin c synthetase 1,95Pc_8408 Dienelactone hydrolase domain protein 1,95Pc_3143 Oligopeptide transporter 1,95Pc_7720 F-box domain-containing protein 1,95Pc_11016 -like family protein 1,95Pc_7254 Galactokinase 1,95Pc_800 Tpr domain containing protein 1,95Pc_3087 Oxidoreductase - 1,94Pc_8984 Cfem domain-containing protein 1,94Pc_2517 Pre-mrna splicing factor 1,93Pc_1240 Snare domain-containing protein 1,93Pc_3415 Nadph-dependent 1-acyldihydroxyacetone phosphate reductase 1,93Pc_10081 Ankyrin and het domain-containing protein 1,93Pc_5088 Hypothetical protein mac_07626 1,93Pc_8904 Chromosome transmission fidelity protein 1,93Pc_8458 Dead deah box rna helicase 1,93Pc_2880 Peroxisomal-coenzyme a synthetase 1,93Pc_1281 Six-bladed beta-propeller -like protein 1,92Pc_4082 Metallo-beta-lactamase domain 1,92Pc_7007 Glycoside hydrolase 1,92Pc_8389 Dihydrofolate synthetase fol3 1,92Pc_6307 Hsp70 family chaperone 1,92Pc_2382 Protamine p1 1,92Pc_147 Wd-repeat protein pop3 1,92Pc_1764 Rna polymerase ii holoenzyme cyclin-like subunit 1,92Pc_5987 Hypothetical protein maa_02149 1,92Pc_7183 Glc8 protein 1,92Pc_4166 Mannose-6-phosphate isomerase 1,91Pc_10907 3-carboxy- -muconate cyclase 1,91Pc_9330 C6 zinc finger domain protein 1,91Pc_8009 Duf92 domain protein 1,91Pc_10259 Alpha- -glucanase 1,91Pc_9912 Arginase agmatinase formiminoglutamase 1,91Pc_6818 Glycosyltransferase family 20 protein 1,90Pc_7631 Fad dependent oxidoreductase superfamily 1,90Pc_2671 Phosphotransferase family protein 1,90Pc_5277 Hypothetical protein mac_04401 1,90Pc_2036 Quinate dehydrogenase 1,89Pc_9114 Cation diffusion facilitator family metal ion 1,89Pc_7862 Er to golgi transporter yif1 1,89Pc_4520 Isoflavone reductase family protein 1,89Pc_983 Syntaxin 5 1,89Pc_3395 Ncs1 nucleoside transporter family protein 1,89Pc_1372 Short-chain dehydrogenase 1,88Pc_3288 Nonselective cation channel 1,88Pc_11540 --- n/a --- 1,88Pc_2881 Peroxisomal targeting signal receptor 1,88Pc_2211 Protein kinase activator 1,88Pc_1541 Serine protein 1,88Pc_10694 Amp-binding enzyme, putative 1,87

Pc_5260 Hypothetical protein mac_04790 1,87Pc_2029 Quinone oxidoreductase 1,87Pc_7303 Fungal transcriptional regulatory-like protein 1,87Pc_9422 C6 transcription 1,87Pc_6859 Glycosyl 1,86Pc_9345 C6 transcription factor 1,86Pc_6272 Hypercellular protein 1,86Pc_9365 C6 transcription factor 1,86Pc_3339 Nitrate reductase 1,86Pc_9646 Beta-lactamase family protein 1,85Pc_3301 Non-ribosomal peptide synthetase 1,85Pc_8566 Cytochrome p450 1,85Pc_3549 N-terminal binuclear zn cluster-containing dna binding domain-containing p 1,85Pc_8176 Domain-containing protein 1,84Pc_12 Zn 2cys6 cluster transcripitional activator 1,84Pc_7594 Family protein 1,84Pc_10380 Alcohol dehydrogenase 1,84Pc_11189 Hypothetical protein 1,84Pc_7541 Fe(2+) transport protein 3 1,84Pc_4972 Hypothetical protein nechadraft_100673 1,84Pc_9619 Bifunctional purine biosynthetic protein 1,83Pc_11178 Mus38-like protein 1,83Pc_5873 Hypothetical protein maa_04019 1,83Pc_9425 C6 transcription 1,83Pc_2941 Peptidase u61 ld-carboxypeptidase a 1,83Pc_3700 Mitogen-activated protein kinase maf1 1,82Pc_1543 Serine palmitoyltransferase 2 1,82Pc_2040 Qde2-like protein 1,82Pc_6416 Histidine kinase hhk13p 1,82Pc_8259 Dna replication licensing factor mcm2 1,82Pc_3649 Mrna cleavage factor complex component pcf11 1,82Pc_8991 Cfem domain protein 1,82Pc_5886 Hypothetical protein maa_03802 1,82Pc_2585 Polyketide synthase 1,82Pc_5618 Hypothetical protein maa_08739 1,82Pc_777 Transaldolase 1,81Pc_3509 Nad dependent epimerase 1,81Pc_980 T-complex protein 1 subunit beta 1,81Pc_3148 Oligopeptide transporter 1,80Pc_10894 3-hydroxyacyl-coa dehydrogenase, putative 1,80Pc_133 Wsc domain-containing protein 1,80Pc_10782 5-oxoprolinase 1,80Pc_5648 Hypothetical protein maa_07938 1,79Pc_7949 Elmo ced-12 family protein 1,79Pc_11731 --- n/a --- 1,79Pc_5835 Hypothetical protein maa_04530 1,79Pc_9938 Antiviral protein 1,79Pc_805 Tpa_inf: galactose oxidase precursor 1,79Pc_1106 Subtilisin-like protease pr1a 1,79Pc_1519 Serine threonine protein kinase 1,79Pc_7218 Gdp gtp exchange factor 1,79

Pc_5620 Hypothetical protein maa_08735 1,78Pc_10270 Alpha beta hydrolase fold-3 domain-containing protein 1,78Pc_1053 Sugar transporter 1,78Pc_9984 Ankyrin repeat-containing 1,77Pc_1960 Related to integral membrane protein pth11 1,77Pc_9304 C6 zinc finger domain-containing protein 1,77Pc_10253 Alpha- -mannosyltransferase 1,77Pc_5334 Hypothetical protein mac_03469 1,77Pc_4463 Kinesin family protein 1,76Pc_4614 Integral membrane protein 1,76Pc_10002 Ankyrin repeat-containing 1,76Pc_10659 Abc bile acid 1,75Pc_634 Transmembrane protein 1,75Pc_6505 Heterochromatin protein one 1,75Pc_5988 Hypothetical protein maa_02132 1,75Pc_8985 Cfem domain-containing protein 1,75Pc_7379 Fungal specific transcription 1,75Pc_1158 Spry domain-containing protein 1,75Pc_10875 3-ketoacyl- thiolase 1,74Pc_10084 Ankyrin and het domain protein 1,74Pc_5479 Hypothetical protein mac_01005 1,74Pc_2386 Prolyl-trna synthetase 1,74Pc_5737 Hypothetical protein maa_06108 1,74Pc_7877 Epoxide hydrolase 1,74Pc_1099 Subtilisin-like protease pr1i 1,73Pc_8689 Cyclin ccl1 1,73Pc_3512 Nad dependent epimerase 1,73Pc_8279 Dna repair protein rad26 1,72Pc_595 Trichome differentiation protein gl1 1,72Pc_10086 Ankyrin and het domain protein 1,72Pc_4322 Lipase thioesterase family protein 1,72Pc_4075 Metallo-beta-lactamase superfamily protein 1,72Pc_3192 Nucleotide-binding domain containing protein 1,72Pc_2793 Phosphatidic acid phosphatase beta 1,72Pc_5909 Hypothetical protein maa_03335 1,71Pc_6944 Glycoside hydrolase family 3 protein 1,71Pc_4498 Karyogamy kar9 1,71Pc_4345 Ligninase h2 precursor 1,70Pc_499 U3 small nucleolar rna-associated protein 1,70Pc_3287 Nonsense transcript 1,70Pc_2762 Phosphoenolpyruvate synthase 1,70Pc_4373 Late sexual development protein 1,70Pc_7999 Dynamin family protein 1,69Pc_34 Zinc-binding dehydrogenase 1,69Pc_41 Zinc metalloproteinase 1,69Pc_5759 Hypothetical protein maa_05732 1,69Pc_11234 Hypothetical protein nechadraft_17752 1,69Pc_6871 Glycoside hydrolase family 79 protein 1,69Pc_9697 Base excision dna repair protein 1,69Pc_10080 Ankyrin and het domain-containing protein 1,69Pc_11073 Uncharacterized protein cpur_04620 1,68

Pc_11020 -gpd superfamily base excision dna repair protein 1,68Pc_2182 Protein kinase-like domain 1,68Pc_5016 Hypothetical protein mac_09163 1,68Pc_1478 Serine threonine-protein kinase tel-1 1,68Pc_8114 Duf1339 domain protein 1,67Pc_2646 Phytochrome-like histidine kinase 1,67Pc_10078 Ankyrin domain protein 1,67Pc_11861 --- n/a --- 1,67Pc_6332 Homocitrate synthase 1,67Pc_5915 Hypothetical protein maa_03233 1,67Pc_3136 Oligopeptide transporter opt-like protein 1,66Pc_6797 Glycosyltransferase family 32 protein 1,66Pc_58 Zinc finger protein odd-paired-like 1,66Pc_9467 C6 finger domain 1,66Pc_9530 C2h2 finger domain 1,66Pc_6669 Gtp binding protein 1,66Pc_8919 Chromatin remodelling complex atpase chain isw1 1,65Pc_7767 Extracellular lipase 1,65Pc_4748 Ibr domain-containing protein 1,65Pc_8213 Dnaj domain-containing protein 1,65Pc_1626 Sas10 utp3 c1d 1,65Pc_156 U5 snrnp complex 1,65Pc_3529 Nacht and wd domain protein 1,65Pc_10393 Alcohol dehydrogenase 1,65Pc_371 Unnamed protein product 1,65Pc_9562 Bzip transcription 1,65Pc_7001 Glycoside hydrolase family 105 protein 1,64Pc_10447 Adenosylhomocysteinase 1,64Pc_6845 Glycosyl hydrolase family 32 domain-containing protein 1,63Pc_5014 Hypothetical protein mac_09260 1,63Pc_9835 Aspartate aminotransferase 1,62Pc_2023 Rab2 -family small gtpase 1,62Pc_6008 Hypothetical protein maa_01810 1,62Pc_8570 Cytochrome p450 1,62Pc_2811 Pheromone receptor 1,62Pc_6664 Gtp cyclohydrolase-2 1,62Pc_6945 Glycoside hydrolase family 3 protein 1,62Pc_5273 Hypothetical protein mac_04427 1,62Pc_8998 Centromere binding protein cbh2 1,62Pc_7989 E3 ubiquitin-protein ligase 1,62Pc_9286 C6 zinc finger protein 1,62Pc_1446 Set domain-containing protein 1,62Pc_11129 Protein 1,62Pc_1131 3-beta hydroxysteroid dehydrogenase isomerase 1,61Pc_8838 Condensin complex component cnd2 1,61Pc_9385 C6 transcription 1,60Pc_3878 Mfs transporter 1,60Pc_9309 C6 zinc finger domain protein 1,59Pc_6538 Het domain protein 1,59Pc_9034 Cell wall glucanosyltransferase mwg1 1,59Pc_8518 Cytokinesis protein cyk3 1,59

Pc_7799 Exo-beta- - 1,59Pc_3327 Nitrogen assimilation transcription factor nira 1,58Pc_1108 Subtilisin-like protease pr1a 1,57Pc_1100 Subtilisin-like protease pr1g 1,57Pc_10178 Amine oxidase 1,57Pc_5294 Hypothetical protein mac_04168 1,57Pc_2378 Proteasome component 1,57Pc_8318 Dna mismatch repair protein msh-2 1,57Pc_10766 54s ribosomal protein l3 1,57Pc_1961 Related to integral membrane protein pth11 1,57Pc_335 Urea carboxylase 1,57Pc_517 Tyrosine-protein phosphatase non-receptor type 6 1,56Pc_1207 Som1 protein 1,56Pc_2305 Protein 1,56Pc_3069 Oxysterol-binding protein 1,56Pc_98 D-xylulose kinase a 1,56Pc_1772 Rna lariat debranching 1,56Pc_5748 Hypothetical protein maa_05923 1,56Pc_807 Zn2 cys6 dna-binding protein 1,55Pc_7904 Endosome-associated ubiquitin isopeptidase 1,55Pc_683 Transcriptional repressor 1,55Pc_7598 Family protein 1,55Pc_1655 Salicylate hydroxylase 1,55Pc_3526 Nacht and wd40 domain protein 1,55Pc_7047 Glycerate dehydrogenase 1,55Pc_3064 P-loop ntpase 1,55Pc_583 Tripeptidyl-peptidase 1 precursor 1,55Pc_8384 Dihydroorotate dehydrogenase 1,54Pc_5905 Hypothetical protein maa_03437 1,54Pc_1986 Reducing polyketide synthase 1,54Pc_10487 Acyl- dehydrogenase 1,53Pc_4543 Iron-sulfur cluster-binding rieske family domain protein 1,53Pc_9823 Aspartic proteinase 1,53Pc_2956 Peptidase family s58 1,53Pc_6802 Glycosyltransferase family 31 protein 1,53Pc_10595 Acetate kinase 1,53Pc_9641 Beta-lactamase family protein 1,53Pc_8651 Cysteine desulfurase 1,52Pc_9350 C6 transcription factor 1,52Pc_1757 Rna polymerase ii transcription factor siii subunit a 1,52Pc_4632 Integral membrane protein 1,52Pc_10574 Acetyl- acetyltransferase 1,52Pc_8921 Chromatin remodeling complex subunit 1,52Pc_4574 Integral membrane protein pth11- 1,52Pc_7667 Fad binding domain protein 1,52Pc_6811 Glycosyltransferase family 25 1,52Pc_2878 Peroxisome biosynthesis protein (pas1 peroxin-1) 1,51Pc_1601 Endothiapepsin precursor 1,51Pc_8949 Choline ethanolamine 1,51Pc_6553 Hem oxygenase- multi-helical 1,50Pc_1648 Salicylate hydroxylase 1,50

Pc_10885 3-hydroxyisobutyrate dehydrogenase 1,50Pc_4562 Intracellular serine protease 1,50Pc_9224 Capsule polysaccharide biosynthesis 1,50Pc_10257 Alpha- -mannosidase family 1,49Pc_1662 Saga complex component 1,49Pc_2903 Peroxisomal abc transporter 1,49Pc_9557 Bzip transcription factor 1,49Pc_1746 Rna polymerase-associated protein 1,49Pc_5493 Hypothetical protein mac_00745 1,49Pc_7610 Fad-dependent pyridine nucleotide-disulfide oxidoreductase 1,48Pc_5939 Hypothetical protein maa_02870 1,48Pc_10906 3-carboxymuconate cyclase 1,48Pc_7778 Exported protein 1,48Pc_7030 Glycerophosphoryl diester phosphodiesterase family protein 1,48Pc_2761 Phosphoesterase superfamily protein 1,47Pc_10096 And ankyrin domain protein 1,47Pc_1750 Rna polymerase rpb1 repeat domain protein 1,46Pc_4709 Indoleamine -dioxygenase subfamily 1,46Pc_9388 C6 transcription 1,46Pc_10174 Amino acid 1,46Pc_7668 Fad binding domain protein 1,46Pc_7944 Elongation factor 2 1,46Pc_5235 Hypothetical protein mac_05147 1,46Pc_3037 Palb protein 1,46Pc_4034 Methylcitrate synthase precursor 1,45Pc_4717 Indole-diterpene biosynthesis protein 1,45Pc_10946 26s protease regulatory subunit 6b 1,45Pc_6081 Hypothetical protein maa_00131 1,45Pc_7945 Elongation factor 2 1,45Pc_11797 --- n/a --- 1,45Pc_2623 Plasma membrane snare protein 1,45Pc_3902 Mfs multidrug transporter 1,45Pc_10353 Aldehyde dehydrogenase 1,45Pc_8571 Cytochrome p450 1,45Pc_840 Tol protein 1,45Pc_8677 Cyclin-k 1,44Pc_5804 Hypothetical protein maa_05047 1,44Pc_4765 Hypothetical protein vdag_08728 1,44Pc_9003 Cellulase family protein 1,44Pc_251 Vacuolar transporter chaperone 2 1,44Pc_9659 Beta-glucosidase 1,44Pc_3513 Nad dependent epimerase 1,44Pc_9590 Brct domain-containing protein 1,44Pc_2693 Phosphorylcholine transferase 1,43Pc_10190 Amidohydrolase domain containing protein 1,43Pc_7188 Geranylgeranyl transferase type i beta subunit 1,43Pc_8067 Duf323 domain protein 1,43Pc_2705 Phosphoribosyl transferase domain protein 1,43Pc_9772 Atp-dependent dna helicase 1,43Pc_11205 Hypothetical protein trividraft_67355 1,42Pc_10228 Alpha-l-rhamnosidase a 1,42

Pc_4688 Inosine-uridine preferring nucleoside hydrolase 1,42Pc_9616 Binuclear zinc transcription factor 1,42Pc_10298 Alpha beta 1,41Pc_5627 Hypothetical protein maa_08626 1,41Pc_6641 Gtpase activating protein for 1,41Pc_5862 Hypothetical protein maa_04086 1,41Pc_1938 Restless-like transposase 1,40Pc_3393 Nedd8-activating enzyme e1 catalytic subunit 1,40Pc_7636 Fad dependent oxidoreductase 1,40Pc_7123 Glutamate-1-semialdehyde - 1,40Pc_1803 Ring-8 protein 1,40Pc_9109 Cation-transporting atpase 4 1,40Pc_10640 Abc transporter 1,40Pc_2311 Protein 1,40Pc_6589 Heat repeat protein 1,40Pc_4872 Hypothetical protein triatdraft_280383 1,40Pc_1186 Sphingosine n-acyltransferase lac1 1,39Pc_7465 Flavin-containing monooxygenase fmo 1,39Pc_6431 Histidine acid phosphatase 1,39Pc_9961 Ankyrin unc44 1,38Pc_9538 C-8 acyltransferase 1,38Pc_6121 Hypothetical protein foxb_12016 1,38Pc_10427 Adp-ribosylglycohydrolase-like protein 1,38Pc_9962 Ankyrin unc44 1,37Pc_5565 Hypothetical protein maa_09836 1,37Pc_8250 Dna-(apurinic or apyrimidinic site) lyase 1,37Pc_3565 N-(5-amino-5-carboxypentanoyl)-l-cysteinyl-d-valine synthase 1,36Pc_137 Wlm domain containing protein 1,36Pc_7670 Fad binding domain protein 1,36Pc_11068 --- n/a --- 1,35Pc_4214 Major facilitator superfamily transporter 1,35Pc_11211 Hypothetical protein trividraft_44451 1,35Pc_8332 Dna helicase 1,35Pc_8284 Dna repair protein 1,35Pc_10063 Ankyrin repeat domain-containing protein 28 1,35Pc_6524 Het domain-containing protein 1,35Pc_7276 G-protein coupled receptor 1,35Pc_8672 Cyclohexanone monooxygenase 1,35Pc_7388 Fungal specific transcription 1,35Pc_8965 Chitin synthase activator 1,35Pc_11162 Pfs domain protein 1,35Pc_3280 Norsolorinic acid reductase 1,34Pc_702 Transcriptional activator xlnr 1,34Pc_3886 Mfs sugar 1,34Pc_2357 Protein 1,34Pc_6181 Hypothetical protein chgg_09447 1,33Pc_4176 Mandelate racemase muconate lactonizing protein 1,33Pc_5007 Hypothetical protein mac_09486 1,33Pc_9737 Atp-dependent rna helicase rok1 1,33Pc_6160 Hypothetical protein foxb_00612 1,33Pc_11775 --- n/a --- 1,33

Pc_1216 Sodium hydrogen exchanger family protein 1,33Pc_7964 Efflux pump antibiotic resistance 1,33Pc_10839 4-aminobutyrate aminotransferase 1,33Pc_8989 Cfem domain-containing protein 1,33Pc_6883 Glycoside hydrolase family 76 protein 1,33Pc_3954 Mfs monocarboxylate 1,32Pc_1247 Sn- -diacylglycerol cholinephosphotransferase 1,32Pc_3986 Mfs 1,32Pc_594 Trichothecene 3-o-acetyltransferase 1,32Pc_8682 Cyclin-dependent kinase g-1 1,32Pc_8294 Dna repair and recombination protein rad5c 1,32Pc_9685 Benzoate 4-monooxygenase cytochrome p450 1,32Pc_11148 Predicted protein 1,32Pc_3354 Nicotinate phosphoribosyltransferase 1,32Pc_4340 Lin1 family protein 1,31Pc_6328 Homogentisate -dioxygenase 1,31Pc_214 Nicotinamide mononucleotide permease 1,31Pc_6673 Grisea protein 1,31Pc_8680 Cyclin-dependent protein 1,31Pc_2866 Pfs domain protein 1,30Pc_8330 Dna helicase 1,30Pc_10328 Alkaline phosphatase 1,30Pc_10044 Ankyrin repeat protein 1,29Pc_6578 Heat shock protein 70 1,29Pc_4407 L-fucose permease 1,29Pc_5776 Hypothetical protein maa_05429 1,29Pc_9127 Catalase cat 1,29Pc_2779 Phosphatidylinositol-4-phosphate 5-kinase its3 1,29Pc_808 Fatty-acid amide hydrolase 1,29Pc_2864 Pfs domain-containing protein 1,29Pc_2625 Plasma membrane phosphatase required for sodium stress response 1,28Pc_5068 Hypothetical protein mac_07915 1,28Pc_8305 Dna polymerase epsilon subunit b 1,28Pc_7002 Glycoside hydrolase family 1 protein 1,28Pc_1598 Secreted endo-beta- -galactanase 1,28Pc_9050 Cell surface 1,28Pc_6256 Hypothetical protein gmdg_05794 1,27Pc_390 Udp-n-acetylglucosamine pyrophosphorylase 1,27Pc_3854 Mfs transporter 1,27Pc_6459 Hexose transporter protein 1,27Pc_10764 56kda selenium binding protein 1,27Pc_9032 Cell wall glycoprotein 1,26Pc_6393 Histone acetyltransferase type b catalytic subunit 1,26Pc_6955 Glycoside hydrolase family 27 protein 1,26Pc_4300 Lpxtg-domain-containing protein 1,26Pc_4375 Las seventeen-binding protein 1,25Pc_662 Translation initiation factor eif-2b subunit family protein 1,25Pc_8580 Cytochrome p450 1,25Pc_4255 Major facilitator superfamily protein 1,25Pc_2925 Peptidyl-prolyl cis-trans isomerase cyp6 1,25Pc_10664 Aaa family atpase-like protein 1,25

Pc_3860 Mfs transporter 1,24Pc_10201 Amidase family protein 1,24Pc_4845 Hypothetical protein trividraft_116499, partial 1,24Pc_6000 Hypothetical protein maa_01932 1,23Pc_1082 Succinate-semialdehyde dehydrogenase 1,23Pc_9896 Argininosuccinate lyase 1,23Pc_3863 Mfs transporter 1,23Pc_9604 Bleomycin hydrolase 1,23Pc_2319 Protein 1,22Pc_9394 C6 transcription 1,22Pc_6207 Hypothetical protein ccm_06981 1,22Pc_6479 Heterokaryon incompatibility protein 1,22Pc_6388 Histone deacetylase 1,22Pc_3907 Mfs multidrug transporter 1,22Pc_7108 Glutamyl-trna amidotransferase 1,21Pc_1174 Splicing factor 3a subunit 3 1,21Pc_11390 Hypothetical protein chgg_10724 1,21Pc_6804 Glycosyltransferase family 31 protein 1,21Pc_6421 Histidine kinase 1 1,21Pc_10202 Amidase family protein 1,21Pc_2103 Protoheme ix farnesyltransferase 1,20Pc_4224 Major facilitator superfamily transporter 1,20Pc_367 Unsaturated glucuronyl hydrolase 1,20Pc_11093 Ubiquitin fusion degradation protein 1,20Pc_384 Uncharacterized conserved protein 1,20Pc_7837 Eukaryotic aspartyl protease family protein 1,19Pc_4227 Major facilitator superfamily transporter 1,19Pc_9558 Bzip transcription factor 1,19Pc_2352 Protein 1,19Pc_6807 Glycosyltransferase family 31 protein 1,18Pc_198 Ankyrin repeat domain-containing protein 50 1,18Pc_4228 Major facilitator superfamily transporter 1,18Pc_8589 Cytochrome p450 1,18Pc_10313 Allantoate permease 1,18Pc_9644 Beta-lactamase family protein 1,18Pc_8520 Cytochrome p450 pisatin 1,17Pc_3265 Nuclear condensin complex subunit smc4 1,17Pc_2686 Phosphotransferase enzyme family protein 1,17Pc_9057 Cell division-associated protein bimb 1,17Pc_2024 Rab proteins geranylgeranyltransferase component a 1,16Pc_3957 Mfs maltose permease 1,16Pc_5534 Hypothetical protein mac_00152 1,16Pc_1511 Serine threonine protein kinase-like protein 1,16Pc_6372 Histone transcription regulator 1,16Pc_10528 Acid trehalase 1,16Pc_140 3 -5 exonuclease 1,16Pc_787 Tpr domain-containing protein 1,16Pc_3990 Mfs 1,16Pc_886 Thiol protease 1,16Pc_9400 C6 transcription 1,16Pc_6877 Glycoside hydrolase family 79 protein 1,16

Pc_3991 Mfs 1,16Pc_2516 Pre-mrna splicing factor 1,15Pc_10262 Alpha- 1,15Pc_145 Wd40 domain-containing protein 1,15Pc_3871 Mfs transporter 1,15Pc_7730 F-box domain protein 1,15Pc_6683 Gpi transamidase component pig- 1,14Pc_799 30s ribosomal protein s17p-like protein 1,14Pc_6816 Glycosyltransferase family 22 1,14Pc_443 Ubiquitin thiolesterase 1,14Pc_9756 Atp-dependent rna helicase dbp-2 1,14Pc_6840 Glycosyl transferase 1,14Pc_8946 Choline oxidase 1,13Pc_9637 Beta-lactamase-type transpeptidase fold domain containing protein 1,13Pc_9360 C6 transcription factor 1,13Pc_10170 Amino acid 1,13Pc_9477 C6 finger domain 1,13Pc_10571 Acetyl- carboxyltransferase component (subunits alpha and beta) 1,13Pc_8938 Choline transport protein 1,13Pc_697 Transcriptional corepressor of histone genes 1,13Pc_9403 C6 transcription 1,12Pc_8596 Cytochrome p450 1,12Pc_5653 Hypothetical protein maa_07721 1,12Pc_401 Udp-galactopyranose mutase 1,12Pc_10761 6-phosphofructo-2-kinase fructose- 6-bisphosphate 2-phosphatase 1,12Pc_91 Yil166c-like protein 1,12Pc_3328 Nitrite reductase 1,12Pc_4539 Isoamyl alcohol oxidase 1,12Pc_5246 Hypothetical protein mac_05014 1,11Pc_7100 Glutamyl-trna synthetase 1,11Pc_1899 Ribitol kinase 1,11Pc_977 T-complex protein 1 subunit gamma 1,11Pc_3770 Mitochondrial distribution and morphology protein 34 1,11Pc_6119 Hypothetical protein foxb_12584 1,11Pc_1951 Related to tetratricopeptide repeat domain protein-neosartorya fischeri 1,11Pc_10192 Amidohydrolase 3 1,11Pc_7873 Epsin-like protein ent1 2 1,11Pc_7426 Frequency clock protein 1,10Pc_4860 Hypothetical protein triatdraft_317515 1,10Pc_6527 Het domain protein 1,10Pc_1624 Scd2 ral3 1,10Pc_3130 Oligosaccharide translocation protein rft1 1,10Pc_765 Transcription factor 1,09Pc_4830 Hypothetical protein trividraft_198205 1,09Pc_9276 Caib baif family enzyme 1,09Pc_5085 Hypothetical protein mac_07669 1,09Pc_5357 Hypothetical protein mac_03095 1,09Pc_5218 Hypothetical protein mac_05497 1,08Pc_9407 C6 transcription 1,08Pc_9406 C6 transcription 1,08Pc_7320 Fungal transcriptional regulatory protein 1,08

Pc_1282 Sit4 phosphatase-associated protein 1,08Pc_3926 Mfs multidrug 1,08Pc_3611 Multidrug resistance protein fnx1 1,08Pc_1932 Retinol dehydrogenase 1,07Pc_6337 Homeodomain-like protein 1,07Pc_5752 Hypothetical protein maa_05858 1,07Pc_10941 26s proteasome non-atpase regulatory subunit 3 1,07Pc_7147 Hexose transporter 1,07Pc_3076 Oxidoreductase-like protein 1,07Pc_8068 Duf300 domain protein 1,07Pc_9328 C6 zinc finger domain protein 1,07Pc_5854 Hypothetical protein maa_04178 1,06Pc_8830 Conserved fungal protein 1,06Pc_4328 Lipase class 3 family protein 1,06Pc_5154 Hypothetical protein mac_06521 1,06Pc_4499 Kap-like kinetoplast-associated protein 1,06Pc_6684 Gpi transamidase component gpi16 1,06Pc_5032 Hypothetical protein mac_08975 1,05Pc_3899 Mfs peptide 1,05Pc_9411 C6 transcription 1,05Pc_2979 Pentatricopeptide repeat protein 1,05Pc_9119 Cation channel family 1,05Pc_161 Wd repeat protein 1,05Pc_10494 Acyl- dehydrogenase 1,04Pc_10992 1-phosphatidylinositol- -bisphosphate phosphodiesterase gamma 2 1,04Pc_2818 Phenylacetyl- ligase 1,04Pc_4244 Major facilitator superfamily transporter 1,04Pc_8288 Dna repair protein 1,04Pc_5539 Hypothetical protein mac_00085 1,04Pc_10239 Alpha-glucosidase 1,03Pc_6373 Histone promoter control 2 1,03Pc_7137 Glucose-repressible alcohol dehydrogenase transcriptional effector 1,03Pc_4552 Iq calmodulin-binding motif protein 1,03Pc_261 Vacuolar protein sorting-associated protein vps17 1,03Pc_4298 Lpxtg-motif cell wall anchor domain 1,03Pc_3387 Negative acting factor 1,02Pc_5272 Hypothetical protein mac_04428 1,02Pc_8785 Conserved leucine-rich repeat protein 1,02Pc_1760 Rna polymerase ii transcription elongation factor 1,02Pc_8423 Dextranase 1,02Pc_9006 Cellular morphogenesis protein 1,02Pc_9039 Cell wall biogenesis protein mhp1 1,01Pc_2334 Protein 1,01Pc_7201 General amino-acid permease gap1 1,01Pc_8173 Domain-containing protein 1,01Pc_6156 Hypothetical protein foxb_01651 1,00Pc_6968 Glycoside hydrolase family 2 protein 1,00Pc_730 Transcription factor vib-1 1,00Pc_3537 Nacht and ankyrin domain protein 0,99Pc_6827 Glycosyltransferase family 2 protein 0,99Pc_8931 Cholinesterase 0,99

Pc_8324 Dna lyase 0,99Pc_6956 Glycoside hydrolase family 27 protein 0,98Pc_9416 C6 transcription 0,98Pc_1552 Serine carboxypeptidase 0,98Pc_9964 Ankyrin unc44 0,98Pc_4961 Hypothetical protein nechadraft_45421 0,97Pc_10207 Amidase family protein 0,97Pc_7466 Flavin-containing monooxygenase 0,97Pc_8113 Duf1446 domain-containing protein 0,96Pc_9418 C6 transcription 0,96Pc_5809 Hypothetical protein maa_04974 0,96Pc_192 Wd domain containing protein 0,96Pc_6148 Hypothetical protein foxb_03407 0,96Pc_1842 Ribosome biogenesis gtpase 0,95Pc_8952 Choline dehydrogenase 0,95Pc_3597 Mus7 mms22 conserved region 0,95Pc_4433 Kinetoplast-associated protein kap 0,95Pc_9891 Arginyl-trna synthetase 0,95Pc_9331 C6 zinc finger domain protein 0,95Pc_1182 Spindle poison sensitivity protein 0,95Pc_3619 Multidrug resistance protein 0,94Pc_795 Tpr domain-containing protein 0,94Pc_2816 Phenylalanine ammonia-lyase 0,93Pc_10543 Acid 0,93Pc_3237 Nuclear protein sa-1 0,93Pc_2894 Peroxisomal copper amine oxidase 0,93Pc_2147 Protein phosphatase 2c domain containing protein 0,93Pc_8741 Creatine transporter 0,93Pc_3993 Mfs 0,93Pc_6640 Gtpase binding protein rid1 0,93Pc_8004 Dynactin ro-3 0,92Pc_7998 Dynamin family protein 0,92Pc_9367 C6 transcription factor 0,92Pc_10790 5 -nucleotidase 0,91Pc_3546 N-terminal fungal transcription regulatory domain-containing protein 0,91Pc_6414 Histidine kinase hhk2p 0,90Pc_7204 General amino-acid permease gap1 0,90Pc_718 Transcription initiation factor tfiid subunit 12 0,90Pc_5549 Hypothetical protein maa_10277 0,90Pc_47 Zinc homeostasis factor 1 0,90Pc_6055 Hypothetical protein maa_00749 0,89Pc_2341 Protein 0,89Pc_7525 Ferric-chelate reductase 0,89Pc_2609 Poly polymerase 2 adp-ribosyltransferase 2 0,89Pc_10588 Acetolactate synthase 0,89Pc_9369 C6 transcription factor 0,89Pc_10065 Ankyrin repeat domain protein 0,88Pc_8932 Cholinesterase 0,88Pc_2146 Protein phosphatase inhibitor 0,88Pc_7380 Fungal specific transcription 0,87Pc_6180 Hypothetical protein chlncdraft_145486 0,87

Pc_10628 Abc transporter 0,87Pc_9433 C6 transcription 0,87Pc_6846 Glycosyl hydrolase family 20 0,86Pc_199 Vps9 domain protein 0,86Pc_8411 Dicer-like protein 1 0,86Pc_276 Vacuolar membrane protein 0,86Pc_6522 Het domain-containing protein 0,86Pc_3007 Patatin-like serine hydrolase 0,85Pc_2832 Phd finger domain-containing protein 0,85Pc_833 Topoisomerase ii-associated protein pat1 0,85Pc_8229 Dna-directed rna polymerase iii subunit rpc1 0,85Pc_3010 Patatin family 0,85Pc_9128 Catalase a 0,85Pc_8277 Dna repair protein rad32 0,85Pc_8299 Dna polymerase zeta catalytic subunit 0,85Pc_3389 Negative acting factor 0,84Pc_3074 Oxidosqualene:lanosterol cyclase 0,84Pc_1921 Rho gtpase activator 0,84Pc_9334 C6 zinc finger domain protein 0,83Pc_2195 Protein kinase snf1 0,83Pc_9500 C2h2 type zinc finger containing protein 0,83Pc_10670 Aaa family 0,83Pc_7742 F-box and wd40 domain 0,82Pc_7382 Fungal specific transcription 0,82Pc_9874 Chromatin remodeling complex subunit 0,82Pc_3401 Nb-arc and tpr domain protein 0,82Pc_7792 Exocyst complex component sec6 0,82Pc_8861 Coatamer subunit protein 0,82Pc_2985 Pentatricopeptide repeat containing protein 0,81Pc_9770 Atp-dependent dna helicase pif1 0,81Pc_716 Transcription initiation factor tfiid subunit 5 0,81Pc_9441 C6 transcription 0,81Pc_535 Tubulin-tyrosine ligase 0,81Pc_2101 Protoplast regeneration and killer toxin resistance protein 0,80Pc_9230 Cap binding protein 0,80Pc_6792 Glycosyltransferase family 39 protein 0,80Pc_6864 Glycoside hydrolase family 95 protein 0,80Pc_209 Chloride channel 0,80Pc_10783 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase 0,80Pc_6466 Hexose transporter 0,80Pc_2347 Protein 0,79Pc_9513 Urea carboxylase 0,79Pc_1847 Ribosome assembly protein 0,79Pc_1497 Serine threonine-protein kinase mak 0,79Pc_7509 Fha domain containing protein 0,79Pc_6162 Hypothetical protein fg10556.1 0,79Pc_148 Wd-repeat protein 0,79Pc_270 Vacuolar protein sorting-associated protein vps13 0,78Pc_3119 Opt oligopeptide transporter 0,78Pc_4962 Hypothetical protein nechadraft_42798 0,78Pc_10233 Alpha-ketoglutarate-dependent sulfonate dioxygenase 0,77

Pc_10082 Ankyrin and het domain-containing protein 0,77Pc_4455 Kinesin light 0,77Pc_1492 Serine threonine-protein kinase prp4 0,77Pc_8001 Dynamin family protein 0,77Pc_2983 Pentatricopeptide repeat domain-containing protein 0,77Pc_9546 C-1-tetrahydrofolate synthase 0,76Pc_8361 Dipeptidyl aminopeptidase 0,76Pc_8700 Cutinase transcription factor 1 alpha 0,75Pc_2091 Pumilio domain-containing protein 0,74Pc_2840 Phd and ring finger domain 0,74Pc_10833 4-coumarate- ligase 2 0,74Pc_446 Ubiquitin ligase subunit 0,74Pc_7386 Fungal specific transcription 0,73Pc_12016 --- n/a --- 0,72Pc_998 Swi snf family dna-dependent atpase 0,72Pc_6134 Hypothetical protein foxb_08229 0,72Pc_10921 2og-fe oxygenase superfamily protein 0,71Pc_1112 Probable subtilisin-like serine protease 0,71Pc_2128 Protein sey1 0,71Pc_6422 Histidine kinase 1 0,71Pc_1041 Sulfatase domain protein 0,70Pc_2096 Psp1 domain-containing protein 0,70Pc_6423 Histidine kinase 1 0,70Pc_10043 Ankyrin repeat protein 0,70Pc_8194 Domain protein 0,70Pc_6441 High-temperature-induced dauer-formation protein 0,70Pc_9279 Cadherin-like protein 0,69Pc_760 Transcription factor (snd1 p100) 0,69Pc_5115 Hypothetical protein mac_07160 0,69Pc_3655 Mrna 3 -end-processing protein rna14 0,69Pc_5593 Hypothetical protein maa_09288 0,69Pc_922 C6 finger domain-containing protein 0,69Pc_4157 Map kinase kinase kinase ste11 0,68Pc_6523 Het domain-containing protein 0,68Pc_2809 Pheromone-regulated membrane protein 0,68Pc_835 Topoisomerase i 0,68Pc_5965 Hypothetical protein maa_02448 0,68Pc_4251 Major facilitator superfamily transporter 0,67Pc_206 Von willebrand domain containing protein 0,67Pc_6686 Gpi inositol-deacylase 0,65Pc_5555 Hypothetical protein maa_10126 0,64Pc_3363 Nf-x1 finger and helicase domain 0,64Pc_9869 Arrestin domain-containing protein 0,64Pc_275 Vacuolar protein sorting protein 0,63Pc_1132 Sterol regulatory element binding protein sre1 0,63Pc_11417 Het domain protein 0,62Pc_3276 Non-ribosomal peptide synthetase 0,62Pc_1355 C2h2 type zinc finger domain containing protein 0,62Pc_7397 Fumarylacetoacetate hydrolase family protein 0,62Pc_7527 Ferric-chelate reductase 0,61Pc_11079 Augustus_masked-scaffold373-abinit-gene- -mrna-1 0,59

Pc_7943 Elongation factor 3 0,59Pc_6973 Glycoside hydrolase family 2 protein 0,59Pc_10000 Ankyrin repeat-containing 0,59Pc_945 Tbc domain-containing protein 0,58Pc_6929 Glycoside hydrolase family 47 protein 0,58Pc_2383 Prostaglandin g h synthase 2 cyclooxygenase pgh2 0,58Pc_7995 Dynein heavy chain 0,57Pc_6675 Gram domain-containing protein 0,57Pc_8331 Dna helicase 0,57Pc_51 Zinc finger transcription factor 1 0,55Pc_7239 Garp complex component 0,55Pc_7437 Forkhead domain-containing protein 0,54Pc_1431 Sh3 domain-containing protein 0,54Pc_6211 Hypothetical protein ccm_05969 0,53Pc_5012 Hypothetical protein mac_09321 0,53Pc_2577 Polyketide synthase 0,51Pc_9786 Abc transporter 0,51Pc_1252 Smc1 protein 0,49Pc_8725 Cullin binding protein 0,49Pc_8670 Cycloheximide resistance protein 0,49Pc_10781 5-oxoprolinase 0,48Pc_2234 Protein family upf0592 0,48Pc_6415 Histidine kinase hhk1p 0,48Pc_653 Translational activator gcn1 0,47Pc_8184 Domain-containing protein 0,45Pc_7252 Galactonate dehydratase 0,45Pc_2700 Phosphoribosylformylglycinamidine synthase 0,45Pc_4117 Meiotic regulator-interacting 0,43Pc_9710 Autophagy-related protein 11 0,41Pc_10620 Abc transporter family protein 0,41Pc_3520 Nacht nucleoside triphosphatase 0,39Pc_542 Gtpase activating protein 0,39Pc_4464 Kinesin family protein 0,37Pc_7547 Fatty acid synthase subunit alpha 0,37Pc_4458 Kinesin heavy chain 0,36Pc_3584 Myb-like dna-binding 0,35Pc_3365 Neutral zinc metallopeptidase 0,34Pc_1919 Rho guanyl nucleotide exchange 0,33Pc_679 Transferase family protein 0,32Pc_6291 Hybrid nrps pks 0,32Pc_6588 Heat repeat protein 0,30Pc_7536 Fermentation associated protein 0,19Pc_6292 Hybrid nrps pks 0,16

n/a, orphan genes (no hit obtained upon interrogation of NCBI GenBank and InterPro databases)

Expression levels values in the last colunm were calculated using the formula: FPKM = number of counts ´ 109/length of transcript ´ total number of mapped sequences

Supplementary Table 2. Protein-encoding genes predicted in the genome of P. chlamydosporia putatively involved in its endophytic and pathogenic behavior.

Category Gene Annotation InterPro classification P. chlamydosporia lifestyle

Endophyte Pathogen

Transporters Pc_3062 P-type ATPase ATPase P-type family + +Transcription factors Pc_9053 Cell pattern formation-associated protein StuA Transcription regulator HTH domain - +

Pc_741 Transcription factor SteA Transcription factor STE-like family - +Signal transducers Pc_10446 Adenylate cyclase Ras-association domain + +

Pc_7293 G protein β subunit Guanine nucleotide-binding protein family + +Pc_6627 G protein α subunit Guanine nucleotide-binding protein family + +Pc_4161 MAP kinase MAP kinase family + +Pc_1532 Serine/threonine protein kinase Protein kinase catalytic domain + +Pc_1911 Rho-like GTPase Cdc42 Rho small GTPase family - +Pc_1153 Spx domain-containing protein SPX domain - +Pc_4272 Mac1 interacting protein 1 Fungi CFEM domain. + -Pc_947 TBC domain Rab-GTPase-TBC domain + -

Secondary metabolism Pc_6292 Hybrid PKS-NRPS Thioesterase type II + +Pathogenesis Pc_6566 Heat-labile enterotoxin α chain Heat-labile enterotoxin family - +

Pc_4296 LTA Heat-labile enterotoxin family - +Pc_6567 Heat-labile α chain Bordetella pertussis toxin A family + -Pc_4477 Killer Kp4 Killer toxin, Kp4/SMK-like, core + -

Nucleic acid modification Pc_6706 Golgi integral membrane protein Histone deacetylation protein Rxt3 + +Pc_1882 Ribonuclease T2 Ribonuclease T2 + +Pc_83 Yt521-β-like splicing YTH domain + +Pc_10918 3'-5' exoribonuclease Csl4 Exosome complex family + +Pc_8285 DNA repair protein DNA repair nuclease, XPF-type/Helicase + -

Metabolic process Pc_2890 Peroxisomal hydratase-dehydrogenase-epimerase MaoC-like dehydratase + -Pc_7246 γ-Butyrobetaine dioxygenase Taurine catabolism dioxygenase family + +Pc_2764 Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxykinase family + +

Hydrolytic enzymes Pc_7788 Exoglucanase type c precursor Glycoside hydrolase 7 family + +Pc_8128 Hypotetical protein Glycoside hydrolase 125 family + +Pc_4063 Metalloprotease Protease M43 + +Pc_4061 Metalloprotease Protease M43 + +Pc_4067 Metalloprotease Protease M43 + +Pc_4059 Metalloprotease Protease M43 + +Pc_8957 Chitinase 1 precursor Glycoside hydrolase 18 family - +Pc_4065 Metalloprotease Protease M43 - +Pc_4060 Metalloprotease Protease M43 - +Pc_4066 Metalloprotease Protease M43 - +Pc_4064 Metalloprotease Protease M43 - +Pc_4056 Metalloprotease 1 Protease M43 - +Pc_4055 Metalloprotease 1 Protease M43 - +Pc_4052 Metalloprotease mep1 Protease M43 - +Pc_10322 Alkaline serine protease Alp1 Protease S8 + -Pc_6923 Glycoside hydrolase family 47 protein Glycoside hydrolase 47 family + -Pc_2150 Protein phosphatase 2C Protein phosphatase 2C family + -Pc_1905 Rhomboid family membrane protein Protease S54 + -

Detoxification Pc_3809 Mitochondrial 18kDa protein Mitochondrial 18kDa protein + +Pc_2892 Peroxisomal hydratase-dehydrogenase-epimerase Short-chain dehydrogenase/reductase SDR family + +Pc_2891 Peroxisomal hydratase-dehydrogenase-epimerase Short-chain dehydrogenase/reductase SDR family + +

Cell wall modification Pc_8965 Chitin synthase activator Sel1-like repeat + +Pc_7389 Fungal hydrophobin Cerato-ulmin hydrophobin family + +Pc_6283 Hydrophobin Cerato-ulmin hydrophobin family + +Pc_926 Tetraspanin Tetraspanin/Peripherin family + +

Cell division Pc_535 Tubulin-tyrosine ligase Tubulin-tyrosine ligase family + -Pc_8299 DNA polymerase ζ catalytic subunit DNA-directed DNA polymerase, family B + +

Unknown Pc_9149 Cas1 appressorium specific protein Family DUF3129 + +Pc_6506 HET-s domain-containing protein – + +Pc_2091 Pumilio domain-containing protein Armadillo-like helical domain + +Pc_9231 Candidate effector 5 – + -Pc_8503 Cytosolic regulator pianissimo Armadillo-like helical + -Pc_2061 Pyridoxine biosynthesis protein Vitamin B6 biosynthesis protein + -Pc_9565 Blastomyces yeast-phase-specific protein Bys1 family protein + -

Pc_9727 ATPase family aaa domain-containing protein 1 AAA+ ATPase domain + +Pc_2899 Peroxisomal biogenesis factor 6 AAA+ ATPase domain + +Pc_7871 ER lumen protein retaining receptor ER lumen protein retaining receptor family - +

The annotation and InterPro classification of P. chlamydosporia protein-encoding genes was carried out using the Blast2GO suite. Genes expressed during endophytic

colonization belonging to the Biological Process GO domain, Interaction between species GO term, are indicated by a + symbol in the 'lifestyle Endophyte' column,

and genes not expressed by a – symbol. Genes with homologous counteparts in the PHI database and belonging to the Biological Process GO domain, Interaction

between species GO term, are indicated by a + symbol in the 'lifestyle Pathogen' column, and genes lacking a PHI database homolog by a – symbol.

Supplementary Table 3. Hydrolytic enzyme-encoding genes predicted in the genome of P. chlamydosporia and expressed during its endophytic behavior.

Hydrolytic enzyme type

Catalytic type Family Description Number of genesPredicted Expressed

Proteases Serine proteases S01 Trypsins 9 (7) 7 (6)S08 Subtilisins 32 (16) 22 (12)S09 Prolyl oligopeptidases 21 (7) 4 (1)S10 Serine carboxypeptidases 16 (7) 8 (4)S12 D-Ala-D-Ala carboxypeptidases 29 (7) 19 (6)S14 Peptidase Clp (type 1) 1 0S15 Xaa-Pro dipeptidyl-peptidases 2 1S16 ATP-dependent peptidases 2 (1) 2 (1)S26 Signal peptidases 2 (2) 1 (1)S28 Exopeptidases of prolyl bonds 4 (4) 4 (4)S33 Prolyl aminopeptidases 56 (13) 31 (8)S53 Subtilisins 6 (5) 3 (2)S54 Rhomboid 2 2S58 Aminopeptidases 3 3S59 Autolytic endopeptidases 1 1S66 LD-carboxypeptidases 3 (1) 3 (1)Total 189 (70) 111 (46)

Metalloproteases M01 Zinc aminopeptidases 6 (1) 6 (1)M03 Oligopeptidases 7 4M04 Zinc metalloproteases 2 (1) 1M06 Zinc metalloproteases 1 (1) 1 (1)M10 Zinc metalloendopeptidases 1 1M12 'ADAM' peptidases 2( 1) 2 (1)M14 Metallocarboxypeptidases 3 (1) 3 (1)

M16 Metalloendopeptidases 8 1 M18 Metalloaminopeptidases 2 0M19 Dipeptidases 2 0M20 Glutamate carboxypeptidases 16 (4) 13 (2)M22 Proteases of O-sialoglycosylated proteins 2 2M23 β-lytic metallopeptidases 22 18M24 Methionyl aminopeptidases 13 (1) 11 (1)M28 Aminopeptidases and carboxypeptidases 9 (7) 9 (7)M35 Deuterolysins 6 (5) 3 (2)M36 Fungalysins 3 (1) 2 (1)M38 Isoaspartyl dipeptidase 14 (1) 10M41 ATP-dependent metalloendopeptidases 2 1M43 Cytophagalysins 14 (13) 5 (4)M48 Mating proteases 2 (1) 2 (1)M49 Dipeptidylpeptidases 2 2M54 Aminopeptidase / Archaelysin 1 1M67 PSMD14 peptidases 5 4M76 Mitochondrion endopeptidases 2 1Total 147(38) 103 (22)

Cysteine C01 Endopeptidases / papains 2 0

proteasesC02 Endopeptidases /calpains 3 3C12 Ubiquitinyl hydrolases 4 (1) 1C14 Cytosolic endopeptidases /caspases 6 4

C15 ω peptidase 1 0C19 Ubiquitinyl hydrolases 15 (1) 13 (1)

C26 ω peptidase γ-glutamyl hydrolases 8 5C40 Dipeptidyl-peptidases 3 (2) 2 (2)C44 Amidophosphoribosyltransferases precursor 4 (1) 3C45 Autolytic endopeptidase 1 1C48 SUMO (small ubiquitin-like modifier) 4 3C50 Endopeptidases / separases 1 1C54 Endopeptidase of glycyl bonds 1 1C56 Putative PfpI endopeptidases 8 (2) 6 (1)C65 Isopeptidase 1 1C69 Dipeptidase 1 (1) 1 (1)C85 Deubiquitinylating peptidases 1 0Total 66(10) 53 (5)

Threonine proteases T01

Proteasome and related compound peptidases 14 (1) 6 (1)

T02 N-terminal nucleophile hydrolases 3 (1) 2 (1)T03 Aminopeptidases 4 (2) 2 (1)T05 Ornithine acetyltransferases 1 0Total 22 (4) 10 (3)

Glutamic proteases

G01 Endopeptidases7 (6) 2 (2)

Total 7 (6) 2 (2)Aspartic proteases A01 Acid proteinases 24 (18) 16 (13)

A11 Transposon-like proteases 3 1A22 Membrane-inserted endopeptidases 2 1A24 Membrane-inserted endopeptidase 1 0A33 Endopeptidase 1 1Total 31 (18) 19 (13)

Total number of proteases

522 (174) 293 (91)

Carbohydrate-active enzymes

Glycosyl hydrolases GH1 β-galactosidases 3 (1) 1

GH2 β-glucuronidases 11 (3) 8 (3)

GH3 β-glucosidases 16 (9) 11 (7)GH5 O-glucosyl hydrolase / cellulases family A 11 (8) 7 (4)GH6 Cellbiohydrolase II /cellulase family B 1 (1) 1GH7 Exoglucanase / cellulase family B 1 (1) 1

GH10 Endo-1,4-β-xylanase / cellulase family F 1 (1) 1GH11 Xylanase / cellulases family G 1 (1) 1GH12 Endoglucanases / cellulases family H 2 (2) 1 (1)

GH13 Maltases / oligo-glucosidases 6 (1) 6 (1)GH15 Glucoamylases 2 (1) 1 (1)GH16 Xyloglucan / xyloglucosyltransferases 20 (13) 13 (7)GH17 1,3-β-D-glucan endohydrolases 6 (5) 3 (2)GH18 Chitinases 22 (15) 7 (6)

GH20 β-1,6-N-acetylglucosaminidases 8 (6) 5 (3)GH23 Lysozyme type G 1 (1) 0GH24 Lysozymes 4 (4) 1 (1)GH25 Lysozymes 4 (4) 1 (1)GH27 α-galactosidases 6 (5) 4 (2)

GH28 Polygalacturonase 3 (3) 3 (3)

GH29 α-1,3/1,4-L-fucosidases 3 (3) 3 (3)GH30 Glucosylceramidases 3 (3) 2 (2)

GH31 α-glucosidases 9 (3) 7 (2)

GH32 Invertase / β-fructosidases 4 (3) 3 (2)GH33 Sialidase/neuraminidase 1 1

GH35 β-galactosidases 3 (3) 1 (1)

GH36 α-galactosidases 3 (1) 1 (1)

GH37 α,α-trehalases 2 (1) 2 (1)

GH38 α-mannosidase 1 1GH43 α-L-arabinofuranosidases 12 (8) 7 (5)GH45 Endoglucanase 1 0

GH47 α-mannosidases 11 (8) 9 (6)GH49 Dextranase 1 (1) 1 (1)

GH54 β-xylosidases 3 (3) 2 (2)

GH55 β-1,3-glucanases, fungal 9 (8) 8 (8)GH61 Copper-dependent monooxygenases 5 (5) 1 (1)

GH63 α-glucosidase 1 1

GH64 β-1,3-glucanases 2 (2) 0

GH65 α-trehalose glucohydrolase 1 (1) 1

GH67 α-glucuronidases 2 1

GH71 α-1,3-glucanases 5 (4) 2 (2)

GH72 β-1,3-glucanosyltransglycosylases 6 (4) 5 (4)GH74 Xyloglucanases 3 1GH75 Chitosanases 11 (10) 4 (4)

GH76 α-1,6-mannanases 17 (14) 10 (8)

GH78 α-L-rhamnosidase 1 1

GH79 β-glucuronidases 8 (6) 4 (4)GH81 Endo-β-1,3-glucanases 2 (1) 1 (1)GH88 D-4,5-unsaturated β-glucuronyl hydrolases 4 1

GH89 α-N-acetylglucosaminidases 3 (1) 1 (1)GH92 Exo-acting α-mannosidases 6 (6) 4 (4)

GH93 Exo-α-L-1,5-arabinanase 1 (1) 0

GH95 α-L-fucosidases 5 (2) 4 (2)

GH99 Glycoprotein endo-α-1,2-mannosidase 1 0GH105 Unsaturated rhamnogalacturonyl hydrolases 3 (2) 2 (1)

GH106 α-L-rhamnosidase 1 0

GH109 α-N-acetylgalactosaminidases 9 (1) 5 (2)

GH114 Endo-α-1,4-polygalactosaminidases 2 (2) 2 (2)

GH115 Xylan α-1,2-glucuronidase 1 1

GH125 Exo-α-1,6-mannosidases 3 (1) 2 (1)

GH127 β-L-arabinofuranosidase 1 (1) 1 (1)

GH128 β-1,3-glucanases 4 (4) 2 (2)GH130 1-β-D-mannopyranosyl-4-D-glucopyranose 1 (1) 0Total 305 (200) 182 (121)

Carbohydrate esterases CE1 Carboxylesterase 41 (10) 19 (5)

CE3 Acetyl xylan esterase 5 (1) 1CE4 Chitin deacetylase 3 (3) 0CE5 Cutinase 9 (7) 4 (4)CE9 N-acetylglucosamine 6-phosphate

deacetylase 1 1CE10 Sterol esterase 93 (29) 34 (17)CE12 Pectin acetylesterase 1 0CE14 N-acetylglucosaminyl-phosphatidylinositol-

N-acetylase4 (2) 2 (2)

CE16 Acetyl esterase 2 (1) 1 (1) Total 159 (54) 62 (29)

Total number of carbohydrate-active enzymes

464 (254) 245 (151)

Total number of hydrolases

986 (428) 537 (241)

The classification of P. chlamydosporia hydrolytic enzymes into families is based on the MEROPS and CAZy

databases classification. The number of proteins predicted in the genome using MAKER is shown in the

penultimate column. The number of hydrolytic enzyme-coding genes detected by RNA-Seq to be expressed

during root endophytic colonization is shown in the last column. The number of putatively secreted proteases are

in parentheses.

Supplementary Table 4. Extracellular hydrolytic enzyme-encoding genes predicted in the P. chlamydosporia genome with homologous counterparts in the PHI database.

Hydrolytic enzyme type

P. chlamydosporiagene

Family PHI ID Homologous gene

Species E-value

Proteases

Pc_280 A01A PHI:697 ugt51E1 Leptosphaeria maculans 2e-165

Pc_1599 A01A PHI:17 ACP Candida tropicalis 4e-24

Pc_1600 A01A PHI:697 ugt51E1 Leptosphaeria maculans 1e-23

Pc_1601 A01A PHI:697 ugt51E1 Leptosphaeria maculans 3e-24

Pc_1602 A01A PHI:697 ugt51E1 Leptosphaeria maculans 1e-21

Pc_1603 A01A PHI:697 ugt51E1 Leptosphaeria maculans 7e-22

Pc_1605 A01A PHI:17 ACP Candida tropicalis 1e-36

Pc_1606 A01A PHI:72 SAP2 Candida albicans 4e-29

Pc_1607 A01A PHI:17 ACP Candida tropicalis 6e-32

Pc_7839 A01A PHI:480 SAP7 Candida albicans 5e-08

Pc_7903 A01A PHI:697 ugt51E1 Leptosphaeria maculans 4e-22

Pc_9233 A01A PHI:68 SAP1 Candida albicans 6e-49

Pc_9817 A01A PHI:697 ugt51E1 Leptosphaeria maculans 4e-18

Pc_9820 A01A PHI:697 ugt51E1 Leptosphaeria maculans 6e-28

Pc_9823 A01A PHI:697 ugt51E1 Leptosphaeria maculans 1e-16

Pc_9825 A01A PHI:126 SAP5 Candida albicans 5e-28

Pc_9826 A01A PHI:17 ACP Candida tropicalis 4e-32

Pc_10180 C44 PHI:502 ADE4 Saccharomyces cerevisiae 1e-142

Pc_3367 M35 PHI:201 AVR-Pi Magnaporthe oryzae 3e-14

Pc_3368 M35 PHI:201 AVR-Pi Magnaporthe oryzae 3e-11

Pc_3369 M35 PHI:201 AVR-Pi Magnaporthe oryzae 2e-14

Pc_8429 M35 PHI:201 AVR-Pi Magnaporthe oryzae 3e-09

Pc_4052 M43B PHI:479 MEP1 Coccidioides posadasii 6e-73

Pc_4055 M43B PHI:479 MEP1 Coccidioides posadasii 4e-69

Pc_4056 M43B PHI:479 MEP1 Coccidioides posadasii 3e-45

Pc_4058 M43B PHI:479 MEP1 Coccidioides posadasii 2e-50

Pc_4059 M43B PHI:479 MEP1 Coccidioides posadasii 2e-56

Pc_4060 M43B PHI:479 MEP1 Coccidioides posadasii 1e-39

Pc_4061 M43B PHI:479 MEP1 Coccidioides posadasii 4e-53

Pc_4062 M43B PHI:479 MEP1 Coccidioides posadasii 7e-46

Pc_4063 M43B PHI:479 MEP1 Coccidioides posadasii 2e-65

Pc_4064 M43B PHI:479 MEP1 Coccidioides posadasii 3e-64

Pc_4065 M43B PHI:479 MEP1 Coccidioides posadasii 3e-55

Pc_4066 M43B PHI:479 MEP1 Coccidioides posadasii 1e-54

Pc_4067 M43B PHI:479 MEP1 Coccidioides posadasii 5e-55

Pc_548 S01A PHI:653 GIP2 Phytophthora sojae 5e-09

Pc_549 S01A PHI:652 GIP1 Phytophthora sojae 3e-18

Pc_550 S01A PHI:653 GIP2 Phytophthora sojae 3e-19

Pc_551 S01A PHI:653 GIP2 Phytophthora sojae 1e-10

Pc_4484 S08B PHI:306 KEX2 Candida albicans 4e-166

Pc_1461 S10 PHI:901 um01886 Ustilago maydis 2e-47

Pc_1552 S10 PHI:901 um01886 Ustilago maydis 2e-47

Pc_9166 S10 PHI:901 um01886 Ustilago maydis 1e-71

Pc_9169 S10 PHI:901 um01886 Ustilago maydis 1e-32

Pc_9168 S10 PHI:901 um01886 Ustilago maydis 1e-27

Glycoside hydrolases

Pc_7926 GH10 PHI:569 XYL3 Fusarium oxysporum 9e-55

Pc_10677 GH11 PHI:571 XYL1 Cochliobolus carbonum 2e-64

Pc_8128 GH125 PHI:785 MGG_04128 Magnaporthe oryzae 1e-173

Pc_6680 GH17 PHI:61 BGL2 Candida albicans 3e-15

Pc_9035 GH17 PHI:816 MGG_04582 Magnaporthe oryzae 1e-31

Pc_6986 GH17 PHI:61 BGL2 Candida albicans 2e-14

Pc_6987 GH17 PHI:816 MGG_04582 Magnaporthe oryzae 8e-58

Pc_8881 GH18 PHI:144 CHT42AAC0 Trichoderma virens 8e-13

Pc_8959 GH18 PHI:144 CHT42AAC0 Trichoderma virens 1e-159

Pc_8958 GH18 PHI:409 BbCHIT1AA Beauveria bassiana 6e-163

Pc_8957 GH18 PHI:144 CHT42 Trichoderma virens 1e-104

Pc_8880 GH18 PHI:144 CHT42 Trichoderma virens 5e-14

Pc_7924 GH18 PHI:144 CHT42 Trichoderma virens 2e-148

Pc_4473 GH18 PHI:144 CHT42 Trichoderma virens 6e-15

Pc_8960 GH18 PHI:144 CHT42 Trichoderma virens 5e-22

Pc_8961 GH18 PHI:144 CHT42 Trichoderma virens 2e-14

Pc_7797 GH28 PHI:115 PGX1 Cochliobolus carbonum 7e-38

Pc_7914 GH28 PHI:3 PGN1 Cochliobolus carbonum 2e-129

Pc_7248 GH28 PHI:115 PGX1 Cochliobolus carbonum 1e-18

Pc_6948 GH3 PHI:748 um00446 Ustilago maydis 3e-155

Pc_6942 GH3 PHI:191 TOM1 Septoria lycopersici 3e-65

Pc_6947 GH3 PHI:24 Avenacinase Gaeumannomyces graminis 2e-158

Pc_6949 GH3 PHI:748 um00446No Ustilago maydis 2e-126

Pc_6951 GH3 PHI:24 Avenacinase Gaeumannomyces graminis 2e-135

Pc_6946 GH3 PHI:24 Avenacinase Gaeumannomyces graminis 2e-151

Pc_6859 GH3 PHI:24 Avenacinase Gaeumannomyces graminis 8e-08

Pc_6945 GH3 PHI:191 TOM1 Septoria lycopersici 1e-169

Pc_10238 GH31 PHI:1071 Gas1 Ustilago maydis 6e-09

Pc_6938 GH31 PHI:1071 Gas1 Ustilago maydis 0

Pc_6933 GH37 PHI:794 MGG_09471 Magnaporthe oryzae 4e-25

Pc_9669 GH5 PHI:323 VFGLU1 Verticillium fungicola 5e-165

Pc_6917 GH5 PHI:547 CEL5A Botrytis cinerea 5e-80

Pc_6918 GH5 PHI:547 CEL5A Botrytis cinerea 2e-31

Pc_7925 GH5 PHI:323 VFGLU1 Verticillium fungicola 7e-69

Pc_9008 GH6 PHI:569 XYL3 Fusarium oxysporum 2e-09

Pc_7788 GH7 PHI:566 cel2 Cochliobolus carbonum 7e-74

Pc_6901 GH72 PHI:434 GEL2 Aspergillus fumigatus 1e-75

Pc_6902 GH72 PHI:522 GAS1 Fusarium oxysporum 0

Pc_9680 GH72 PHI:33 PHR1 Candida albicans 2e-69

Pc_11040 GH72 PHI:434 GEL2 Aspergillus fumigatus 1e-127

Carbohydrate esterases

Pc_604 CE10 PHI:541 CUTA Botrytis cinerea 3e-44

Pc_9186 CE10 PHI:541 CUTA Botrytis cinerea 5e-36

Pc_9188 CE10 PHI:541 CUTA Botrytis cinerea 8e-21

Pc_8930 CE10 PHI:541 CUTA Botrytis cinerea 1e-30

Pc_9189 CE10 PHI:541 CUTA Botrytis cinerea 8e-45

Pc_8994 CE10 PHI:541 CUTA Botrytis cinerea 1e-46

Pc_8707 CE5 PHI:407 PBC1 Pyrenopeziza brassicae 1e-20

Pc_8706 CE5 PHI:407 PBC1 Pyrenopeziza brassicae 7e-46

Pc_10579 CE5 PHI:569 XYL3 Fusarium oxysporum 9e-07

Pc_9214 CE5 PHI:407 PBC1 Pyrenopeziza brassicae 1e-16

Pc_7606 CE5 PHI:747 um004 Ustilago maydis 1e-22

Pc_9187 CE10 PHI:541 CUTA Botrytis cinerea 1e-46

Pc_10266 CE10 PHI:541 CUTA Botrytis cinerea 5e-46

Pc_4331 CE10 PHI:541 CUTA Botrytis cinerea 0

Pc_3018 CE10 PHI:541 CUTA Botrytis cinerea 5e-43

Pc_9184 CE10 PHI:541 CUTA Botrytis cinerea 5e-24

Pc_8931 CE10 PHI:541 CUTA Botrytis cinerea 6e-40

Pc_606 CE10 PHI:541 CUTA Botrytis cinerea 1e-36

Pc_9179 CE10 PHI:541 CUTA Botrytis cinerea 1e-25

Pc_9191 CE10 PHI:541 CUTA Botrytis cinerea 3e-42

Pc_9189 CE10 PHI:541 CUTA Botrytis cinerea 8e-45

Pc_8994 CE10 PHI:541 CUTA Botrytis cinerea 1e-46

Pc_8707 CE5 PHI:407 PBC1 Pyrenopeziza brassicae 1e-20

Pc_8706 CE5 PHI:407 PBC1 Pyrenopeziza brassicae 7e-46

Pc_10579 CE5 PHI:569 XYL3 Fusarium oxysporum 9e-07

Pc_9214 CE5 PHI:407 PBC1 Pyrenopeziza brassicae 1e-16

Pc_7606 CE5 PHI:747 um004 Ustilago maydis 1e-22

Lipases

Pc_599 – PHI:432 FGL1 Fusarium graminearum 1e-21

Pc_4336 – PHI:432 FGL1 Fusarium graminearum 1e-40

Pc_4337 – PHI:432 FGL1 Fusarium graminearum 8e-48

Pc_4338 – PHI:432 FGL1 Fusarium graminearum 2e-62

Pc_7517 – PHI:432 FGL1 Fusarium graminearum 3e-23

Pc_7767 – PHI:432 FGL1 Fusarium graminearum 2e-9

Pc_10965 – PHI:432 FGL1 Fusarium graminearum 8e-49

Supplementary Table 5. Number of core genes involved in secondary metabolism pathways predicted in the genomes of P. chlamydosporia and other fungi.

Pathwaya Pcc Expressedb Epfc Maac Macc Bbc Cmc

PKS 15 9 12 24 13 12 9PKS-like 3 2 2 3 4 1 2NRPS 12 4 13 14 13 13 5NRPS-like 8 6 9 9 8 7 8PKS-NRPS 4 2 1 5 1 3 3Total 42 23 37 55 39 36 27

aAbbreviations: PKS, polyketide synthase; NRPS, non-ribosomal peptide synthetase; PKS–NRPS,

hybrid polyketide synthase and non-ribosomal peptide synthetase enzyme. bThe column indicates the number of pathway core genes identified in P. chlamydosporia during its

endophytic colonization of barley roots. cSpecies abbreviations: Pc, P. chlamydosporia; Epf, Epichloë festucae (predicted in this study), Maa,

Metarhizium anisopliae; Mac, M. acridum; Bb, Beauveria bassiana; Cm, Cordyceps militaris.

Supplementary Table 6. Identification of a secondary metabolism gene cluster involved in the radicicol biosynthesis pathway in the P. chlamydosporia genome.

Gene ID

Scaffold number

Genomeannotation

Genename

GenBank accesion no.

PHI ID

PHI gene

Species Expressed

Pc_1986 1640 Polyketide Rdc5 ACD39774 PHI:714 PKS4 F. graminearum +Pc_8529 1640 Cytochrome P450 monooxygenase Rdc4 ACD39773 PHI:438 – – –Pc_4232 1640 Major facilitator superfamily transporter Rdc3 ACD39772 PHI:511 – – –Pc_3312 1640 Non-heme halogenase Rdc2 ACD39971 – – – –Pc_2583 1640 Polyketide Rdc1 ADM86580 PHI:713 PKS13 F. graminearum –Pc_9370 721 C6 transcription factor – – PHI:734 FOW2 F. oxysporum +Pc_9224 242 Capsule polysaccharide biosynthesis – – – – – +Pc_3573 1790 Myo-inositol-1(or 4)-monophosphatase – – – – – –Pc_748 1858 Transcription factor cys6 – – – – – +Pc_9424 2906 C6 transcription factor – – PHI:734 FOW2 F. oxysporum +Pc_473 2426 Ubiquitin carboxyl-terminal hydrolase – – – – – +Pc_4966 242 Hypothetical protein NECHADRAFT_29703 – – – – – –Pc_4213 2079 Major facilitator superfamily transporter – – – – – –Pc_4941 2482 Hypothetical protein NECHADRAFT_87583 – – – – – +

The – symbol indicates no hits returned from InterPro and PHI database searches. The assignment of radicicol cluster genes to P. chlamydosporia was

performed upon Blastp search using the proteins predicted from the genome of this fungus. The 'Expressed' column indicates the radicicol pathway-related

genes detected or not by RNA-Seq during P. chlamydosporia endophytic root colonization.

Supplementary Table 7. Number of protein-coding gene members of selected families in the genomes of P. chlamydosporia and other entomopathogenic and plant pathogenic fungal species.

Protein categories and families Nematophagous Entomopathogens Plant pathogensP. chlamydosporia B. bassiana C. militaris M. anisopliae M. acridum F. graminearum M. oryzae

Lytic enzymesTrypsins 9 23 12 32 17 112 137Subtilisins 38 43 35 55 43 24 29Aspartic proteases 31 21 21 33 25 18 19Carboxypeptidases 16 52 50 42 39 44 27Metallopeptidases 147 98 108 97 91 114 92Lipases 18 43 38 47 41 31 23Cutinases 9 5 4 2 2 12 18Glycoside hydrolases 305 145 135 159 130 219 235Carbohydrate esterases 163 10 12 7 6 20 47TransportersMajor facilitator superfamily 290 242 123 269 236 274 198ABC transporters 58 81 72 58 54 59 51Amino acid/oligopeptide transporters 59 71 79 73 73 96 44Sugar/inositol transporters 87 56 59 60 63 114 67OxidoreductasesAcyl-CoA dehydrogenases 10 12 11 18 14 10 6Alcohol dehydrogenases 70 41 43 52 46 71 65Cytochromes P450 110 83 57 123 100 112 137Short-chain dehydrogenase reductases 138 79 65 73 77 85 93FAD-binding proteins 43 23 14 19 16 32 28Monooxygenases 6 36 16 30 23 22 15Signal transducersPth11-like GPCR 54 23 18 54 40 51 60Protein kinases 153 159 167 161 192 149 135MetabolismCarbohydrate-binding module-containing 52 52 50 47 33 75 68Glycosyl transferases 111 72 68 75 72 81 94Secondary metabolism backbone genes 41 36 28 61 42 37 32Cell wall modificationHydrophobin 7 5 4 3 3 2 4

Supplementary Table 8. Families of protein-coding genes predicted in the genome of P. chlamydosporia expressed during endophytic root colonization and homologous counterparts in the PHI database

Category InterPro family Number of protein coding genes

Predicted Expressed PHI homologous

Transporters Oligopeptide transporters 7 6 7

Drug resistance transporters 16 9 16

Fungal trichothecene efflux pumps 5 1 5

Sugar/inositol transporters 80 50 79

ATPases, P-type 27 18 26

ABC transporters 58 40 54

General substrate transporters 113 61 98

Major facilitator superfamily (MFS) transporters 290 180 156

Amino acid/polyamine transporters 62 41 0

Zinc transport ZntB proteins 15 8 0

Transcription Factors Fungal transcription factors 196 137 98

C2H2 zinc finger transcription factors 74 49 32

Aflatoxin biosynthesis regulatory proteins 5 1 2

Zn2Cys6 fungal-type TFs 203 143 56

Basic leucine zipper (bZIP) TFs 26 15 15

Bromodomains-containing proteins 8 7 0

Stress response DNAJ heat shock proteins 16 13 9

TCP-1 chaperonins. 6 5 0

Signal Transducers Glucanosyltransferases 6 5 6

Adenylate cyclase-associated CAPs 2 1 2

G-proteins α subunit 6 4 6

G-protein β subunit 2 2 2

Root hair defective 3 GTP-binding protein 1 1 1

Pth11-like GPCRs 54 30 52

Small GTPases 26 19 25

Histidine kinases 17 14 16

Protein kinases 153 96 116

Fungal CFEM domain-containing proteins 13 9 6

Ankyrin repeat-containing proteins 149 86 22

WD40 domain-containing proteins 119 100 80

ERCC4 domain-containing proteins 3 3 0

Rab GTPases 27 18 25

Protein phosphatases, 2C-like 8 6 3

HR1 rho-binding repeat proteins 21 17 20

Oxidoreductases Fatty acid synthases 3 1 3

Glucose-methanol-choline oxidoreductases 14 11 14

Alcohol dehydrogenases, zinc-type 70 41 51

Cytochromes P450 110 67 79

Glucose/ribitol dehydrogenases 124 67 74

FAD-containing monooxygenases 43 26 33

Mono functional catalases 6 5 6

Short-chain dehydrogenase/reductases (SDRs) 129 66 68

FAD-binding type 2 domain 43 26 33

Aldo/keto reductases 26 15 11

Monooxygenases 6 4 1

Acyl-CoA dehydrogenases 84 46 8

Metabolic process Aconitase/isopropylmalate dehydratases 5 4 5

Homoserine acetyltransferases 5 1 5

Adenylylsulphate kinases 2 2 2

Carbonic anhydrases 2 2 1

Thiolases 9 7 8

Shikimate kinases 4 3 1

Hexokinases 5 3 4

Acyl-CoA N-acyltransferases 84 46 8

Vitamin B6 biosynthesis protein 1 1 0

Magnesium-dependent phosphatase 1 1 1 0

Cell wall modification Velvet factors 4 3 4

Chitin synthases 2 1 2

Fungal chitin synthases 6 5 6

Cerato-ulmin hydrophobins 7 3 6

Lipopolysaccharide-modifying proteins 9 8 6

Sel1 repeat-containing proteins 6 5 3

Lipopolysaccharide kinases 9 8 6

Supplementary Fig. 1. Combined graphs of hierarchical relationships between GO terms derived from functional annotation of the P. chlamydosporia genome.

A) Metabolic process; B) Cellular process; C) Catalytic activity; D) Binding. Relationships between GO terms were established on the basis of Blast2GO annotations. ID numbers are indicated below each GO term.

A)

B)

C)

D)

Supplementary Fig. 2Functional annotation of P. chlamydosporia genes putatively involved in endophytic and pathogenic behavior.

A) Venn diagram of fungal genes expressed during endophytic colonization of barley roots (RNA-Seq; blue), genes of the P. chlamydosporia genome with counterparts in the PHI database (PHI; yellow), and genes annotated under the Interaction between species GO term (Interaction; green). B) Genes expressed during endophytic colonization with counterparts in the PHI database and annotated under GO Interaction between species. C) Genes with counterparts in the PHI database and annotated under GO Interaction between species. D) Genes expressed during endophytic colonization and annotated under GO Interaction between species. Assignment of protein-coding genes to categories (enlisted to the right of the figure) was performed on the basis of their biological functions described in the InterPro database. The three pie graphs (B-D) represent the percentage of genes annotated within each biological category.