fourth annual pathology educational...

Fourth Annual Pathology

Educational Symposium

October 25-27, 2016

Turner Building Concourse 720 Rutland Avenue

Baltimore, MD 21205

Sponsored by the Department of Pathology

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Description: This Continuing Education event is intended for all employees of the Johns Hopkins Medicine Department of Pathology and Johns Hopkins Medical Laboratories.

Cost: Free for all Pathology and Johns Hopkins Medical Laboratory employees

Pre-registration is encouraged (and required to receive lunch):

Preregistration is open September 12 - October 14, 2016.

Preregistration can be done through the ActivTracker website for all JHMI staff:

http://pathology.jhu.edu/department/training/symposium.

cfm See your Supervisor for approval to attend during your normal working hours.

JHM I.D. badge is required for electronic attendance tracking. Registration: Turner Lower Concourse. Register only once on the first day of attendance to pick up materials and lunch ticket(s). Breaks: Light refreshments will be available free of charge between sessions in the Lower Turner Concourse.

Lunch: A Sandwich or Salad option will be available (while they last) free of charge for attendees who have pre-registered for lunch and attend at least one session that day. (Lunch may not be available for those not pre-registered for lunch.)

Lunch pick-up is in the Turner Lower Concourse: Tuesday, October 25 12:00-12:45p Wednesday, October 26 12:00-12:45p Thursday, October 27 12:00-12:45p

http://pathology.jhu.edu/department/training/symposium.cfm


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Poster Session: Poster presentations will be available for the duration of the Symposium and will allow attendees to receive additional P.A.C.E.® Continuing Education credit. Questions must be answered for a minimum of five posters and a minimum passing score of 80% must be achieved. No partial credits can be awarded, and answers must be turned in by November 11, 2016. Examples:

Questions answered for 5 posters with 80% receive 1.0 CEU. Questions answered for 10 posters with 80% receive 2.0 CEU.

Pre-registration is not required for the Poster Session. Attendance Documentation & Certificate:

1. Swipe I.D. badge or sign in for all sessions attending. (NO CE credit will be available for those arriving more than 10 minutes after

the start time.) 2. Record Session Code on Attendance Documentation

form (provided at the end of the session). 3. Turn in completed Attendance Documentation form at

registration desk or email to Symposium Committee at end of the symposium. Both sign-in / swipe-in & Attendance Documentation form are required to receive your P.A.C.E.® certificate.

4. Certificate and evaluations will be emailed to attendees within three weeks of the Symposium.

Volunteer Opportunities: If you would like to help with the

Symposium, please register at http://signup.com/go/wcmPY5 to sign up. Volunteers are needed in several areas:

Registration Desk: Hand out materials & give directions to rooms. Moderator: Introduce session and speaker. Room Lead: Assist attendees in swiping (Activtracker)/signing in for

their session.

Lunch: Assist attendees with obtaining lunch.

Johns Hopkins Medicine is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program.

http://signup.com/go/wcmPY5

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Tuesday, October 25, 2016

8:00a-3:30p: Registration (Turner Concourse)

Opening Session 8:30a-9:30a Room: Turner Auditorium

Three Women Who Helped Make Hopkins Great

Course # 612-302-16 / 1.0 credit hours

Ralph H. Hruban, MD Baxley Professor and Director of Pathology Professor of Oncology Johns Hopkins University School of Medicine Pathologist-in-Chief Johns Hopkins Hospital Director, Sol Goldman Pancreatic Research Center Johns Hopkins Medicine

Level of Instruction: Basic Category: History/Diversity Target Audience: All are welcome Description: Women have played a critical role in making the Johns Hopkins University School of Medicine great. In this talk Dr. Hruban will highlight the contributions of three of our greatest women—Mary Elizabeth Garrett, Dorothy Reed, and Helen Taussig. Objectives: At the completion of the presentation, the audience will be able to:

Recognize the important role that women have played and continue to play in the School of Medicine

Appreciate that our diversity is our strength

Name a woman who has contributed significantly to the Johns Hopkins University School of Medicine

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9:45a–10:45a Room: TBA

Advanced Serologic Techniques in

Immunohematology


Lorraine N. Blagg, MA, MLS(ASCP)CMSBB Education & Development Coordinator, Transfusion Medicine Program Director, Specialist in Blood Banking Technology Program The Johns Hopkins Hospital

Level of Instruction: Advanced Category: Blood Bank/Immunohematology Target Audience: Technologists, Leads, Supervisors, Managers

Description: Antigen and antibody identification in the immunohematology laboratory may involve varying serologic techniques. This presentation will use case studies to highlight and explain the use of enzymes, chemicals, adsorptions, elutions, and neutralizations to solve complex red blood cell antibody problems. Objectives: At the completion of the presentation, the audience will be able to:

Explain the immunologic assays used in immunohematology

Name at least two enzymes, chemicals, or neutralizing agents and what antigens or antibodies are destroyed by their use

Interpret the results of an adsorption/elution study

Describe how daratumumab interferes with immunohematology testing and recommend a method to resolve it

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Tuesday, October 25, 2016 9:45a–10:45a Room: TBA

Guns, Knives, and Rotting Corpses: A Brief

Introduction to Forensic Medicine


Andrew Guajardo, MD Neuropathology Fellow Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Forensic Pathology Target Audience: All are welcome

Description: Forensic pathology is often misunderstood. Oftentimes, "The CSI effect" has created a gory and dramatic spin on the practice. This lecture will be a presentation on some of the basic findings within the field. Objectives: At the completion of the presentation, the audience will be able to:

Examine a scene of a deceased person, taking note of the surroundings and the initial physiological changes seen after death

Appreciate basic changes that the human body goes through due to decomposition

Identify some common injury patterns

Describe the Maryland state law regarding autopsies

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9:45a–11:45a Room: TBA

General Principles of Breast Cancer Care: Views

from a Pathologist and from an Oncologist Course # 612-304-16 / 2.0 credit hours

Ashley Cimino-Mathews, MD Assistant Professor of Pathology and Oncology Johns Hopkins University School of Medicine

Antonio Wolff, MD Professor of Oncology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Histology Target Audience: All are welcome Description: This two-hour course will provide an introduction to basic and common breast pathology diagnoses with a focus on breast cancer, followed by the general principles of breast cancer treatment from the perspective of the oncologist. Objectives: At the completion of the presentation, the audience will be able to:

Describe the pathologic features of common types of breast cancer

Describe the general principles of breast cancer treatment

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11:00a–12:00p Room: TBA

Sex and the Single Chromosome

(Live Webcast from All Children’s Hospital)


Maxine J Sutcliffe, PhD, FACMG, FCCMG (00208973) Director, Cytogenetics & Molecular Cytogenetics Department of Pathology Johns Hopkins All Children’s Hospital

Level of Instruction: Basic Category: Genetics Target Audience: All are welcome

Description: The presentation will progress through defining sex determination in the embryo to discussing various aspects of sex assignment, including how sex determination can go wrong at the basic gene level. Various anatomical aspects of identifying male and female sex assignment will be reviewed. The presentation will conclude with a review of some basic gender identity issues that will examine hermaphroditism and transgender. Objectives: At the completion of the presentation, the audience will be able to:

Explain how the choices are made in the embryo—am I a boy or a girl?—and how sometimes it goes wrong

Identify the different ways of trying to assign "sex"

Appreciate that assigning sex and gender identity may be different sides of the same coin

Describe some basic concepts of hermaphrodism and transgender

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11:00a–12:00p Room: TBA

The Influence of Preanalytical Variables in Clinical

Chemistry Testing


Jeffrey Chance, PhD Group Leader, Medical Affairs BD Life Sciences - Preanalytical Affairs

Level of Instruction: Intermediate Category: Clinical Chemistry Target Audience: All are welcome

Description: Serum and heparin plasma are the most commonly used sample types in clinical chemistry. A wide range of preanalytical variables can influence the sample quality and testing results for both sample types. These include patient-related factors, as well as factors associated with the collection, handling and processing of blood specimens. In addition, factors unique to each sample type can influence sample quality and test results, including the effect of clotting, the effect of tube additives, and the degree of cellular contamination after processing which can affect the storage stability of various analytes. This presentation will provide an overview of preanalytical variables affecting tests in clinical chemistry, with a special focus on erroneous potassium results. Objectives:

At the completion of the presentation, the audience will be able to:

Describe the major factors which influence sample quality in serum and heparin plasma samples

Describe at least three different causes of erroneous potassium results

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1:00p-2:00p Room: TBA

Introduction to Leukemia and Lymphoma


Jennifer Bynum, MD Resident Physician, PGY4 Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Hematology/ Molecular Target Audience: All are welcome

Description: This presentation will give a broad overview of the classification of leukemia and lymphoma and review various roles in making malignant hematologic diagnoses. The majority of the presentation will be comprised of case studies with discussion. Objectives: At the completion of the presentation, the audience will be able to:

Describe broad categories of leukemia and lymphoma based on morphology, flow cytometry, and molecular studies

Describe the process of making a malignant hematologic diagnoses

Identify frequent pitfalls in making malignant diagnoses

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What's So Special about Special Microtomy?


Lisa Stalnaker-Jackson, AS Histopath Tech II Division of Surgical Pathology The Johns Hopkins Hospital

Level of Instruction: Basic Category: Histology/Surgical Pathology Target Audience: All are welcome

Description: This presentation will show how microtomy needs for a large institution are met through a specialized microtomy section within the Histology Lab. At Johns Hopkins, we meet the histologic needs for the Immunohistochemistry, Molecular, Cytogenetics, Cytology, and Special Stains Labs. We also process a large number of consult cases for our pathologists through our Histology Lab. All of this is done in conjunction with our Consult Office and Archive area by histotechnologists who have received further training in the art of performing paraffin sectioning on blocks that come from various institutions.

Objectives: At the completion of the presentation, the audience will be able to:

Describe the automated microtome technology that is utilized to prepare the best sections possible

Identify the specialized process used to prepare PCR precaution slides for molecular studies

Describe the quality assurance scanning techniques used to limit mistakes

Explain different histologic "tricks" to work with difficult tissue

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Clinical and Laboratory Aspects of Human Leukocyte

Antigens


Annette M. Jackson PhD, D(ABHI) Associate Professor, Department of Medicine Director, Division of Immunogenetics and Transplant Immunology

Level of Instruction: Basic Category: Immunology Target Audience: All are welcome

Description: This lecture will provide an introduction to the HLA system and its clinical relevance in solid organ and hematopoietic stem cell transplantation. Histocompatibility testing performed prior to and following transplantation and challenges in test interpretation will also be discussed.

Objectives: At the completion of the presentation, the audience will be able to:

Describe how the polymorphic nature of HLA provides an advantage for immunity, but a barrier to transplantation

Explain the basics of histocompatibility testing and the methodologies used in the laboratory

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Tuesday, October 25, 2016 2:15p-3:15p Room: TBA

I SPY with My Little Eye.... a Laboratory Non-

Compliance! The Laboratory Inspection Version.


Stephanie Lihvarchik, MT(ASCP)BB, CQA, SSGB Quality Assurance Specialist Hemapheresis and Transfusion Support Services The Johns Hopkins Hospital

Level of Instruction: Intermediate Category: Quality Assurance Target Audience: All are welcome

Description: A fun and interactive presentation on how to prepare for an upcoming inspection. Preparing for an inspection goes beyond just reading and interpreting regulatory requirements. In this presentation, our speaker will provide helpful tips on how to handle inspections, inspectors and non-compliances, in particular how to identify laboratory non-compliances that are often neglected or overlooked. At the end of the presentation, the audience will be able to view laboratory photos with non-compliances. Are you able to SPY the laboratory non-compliance?? Objectives: At the completion of the presentation, the audience will be able to:

Utilize tips on how to handle inspections, inspectors, and non-compliances

Identify and correct laboratory non-compliances before the inspection

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Rapid Phenotypic Antimicrobial Susceptibility

Testing Methods: Making a Comeback!


Patricia (Trish) Simner, PhD, D(ABMM) Director, Bacteriology and Parasitology Johns Hopkins Clinical Microbiology Assistant Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Microbiology Target Audience: All are welcome

Description: This presentation will describe current and future rapid phenotypic antimicrobial susceptibility testing (AST) methods. The laboratory and clinical impact of implementing these tests will be discussed through clinical scenarios that we encountered in the Clinical Microbiology Laboratory. Objectives: At the completion of the presentation, the audience will be able to:

Explain what is rapid phenotypic antimicrobial susceptibility testing method

Describe the different types of rapid AST methods

Describe currently available and future rapid phenotypic antimicrobial susceptibility testing methods

Assess the laboratory and clinical impact of implementing these assays

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How Hospitals Get Paid: Understanding the Basics of

Hospital Finance


Armen Khararjian, MD, MBA Resident Physician, PGY4 Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Management Target Audience: All are welcome

Description: Today's health care system is rapidly changing with an emphasis placed on increasing quality and reducing costs. While we strive to provide high quality care, the basics of hospital finance are not understood by most. In this talk, we will discuss how hospitals get paid and the economic pressures facing the health care system. Objectives: At the completion of the presentation, the audience will be able to:

Explain how hospitals get paid

Describe the economic pressures facing the health care system

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3:30p–4:30p Room: TBA

When Humans Study Humans: The History and

Ethics of Human Subjects Research from Tuskegee to

Today


Lisa M. Rooper, MD Assistant, Advanced Specialty Training Program in Surgical Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: General/History/Research/ Ethics/Safety Target Audience: All are welcome

Description: Great breakthroughs in clinical research are announced almost every day at The Johns Hopkins Hospital. But while the Pathology Department often provides extensive support for these research activities, it is not always clear to us in the laboratory what research on human subjects entails and how patients are protected from exploitation and dangers while participating in it. This talk will discuss the history and ethics of research using human subjects with a focus on what went wrong in egregious research abuses like the Tuskegee syphilis study, Nazi concentration camps, and the Milgram experiment. It will also detail how the first protections for research subjects were put into place, what rules guide human research today, and what should you should expect if you consider participating in a clinical trial. Objectives: At the completion of the presentation, the audience will be able to:

Summarize the ethical issues surrounding human subjects research

Describe what went wrong during historical abuses of research subjects

Discuss what protections exist for human research subjects today

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Wednesday, October 26, 2016

8:00a-3:30p: Registration (Turner Concourse) 8:30a-9:30a Room: TBA

The Recognition and Treatment of Anxiety and

Depression in Adolescents


Karen Swartz, MD Associate Professor of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Director, Mood Disorders Clinical Program

Level of Instruction: Basic Category: General Target Audience: All are welcome

Description: Depression and anxiety often begin during adolescence and these symptoms of anxiety and depression are often missed in teenagers. It is critical that these very treatable illnesses be recognized and treated since there are potential serious consequences for missing these illnesses and delaying treatment. Objectives: At the completion of the presentation, the audience will be able to:

Recognize the symptoms of anxiety disorders in adolescents

Recognize the symptoms of depression in adolescents

Discuss the treatment options for anxiety and depression in adolescents

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8:30a-9:30a Room: TBA

Mass Spectrometry-based MRM Assays: The Future

Diagnostics


Stefani Thomas, PhD Research Associate, Department of Pathology Division of Clinical Chemistry Center for Biomarker Discovery and Translation Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Clinical Chemistry Target Audience: All are welcome

Description: Be prepared for the future arrival of targeted mass spectrometry-based assays in the clinical laboratory! Advances in mass spectrometry have enabled the reproducible, sensitive and accurate quantification of hundreds of analytes in a single run via a method known as multiple reaction monitoring (MRM). MRM is widely accepted as the most sensitive and specific targeted mass spectrometric method. MRM assays offer many advantages compared to antibody-based assays such as ELISA and Western blot. Hence, MRM assays have considerable promise as the next wave of novel diagnostics. This presentation will introduce several fundamental principles of targeted mass spectrometry and MRM assays. Although the focus of the presentation will be on protein-based MRM assays, consideration will also be given to small molecule-based MRM assays. Objectives: At the completion of the presentation, the audience will be able to:

Explain the fundamental principles of MRM assays

Identify the advantages and disadvantages of MRM assays compared to antibody-based immunoassays

Describe the main barriers to the widespread adoption of mass spectrometry-based assays by the clinical laboratory

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Infection Control for a Biocontainment Unit:

Planning, Policy Development, and Training


Polly Trexler, MS, CIC Director of Operations, Hospital Epidemiology and Infection Control The Johns Hopkins Hospital

Brandon Ellis, MLS (ASCP)CM Supervisor, Clinical Microbiology Laboratory The Johns Hopkins Hospital

Level of Instruction: Basic Category: Microbiology/Quality Assurance/Safety Target Audience: All are welcome

Description: This talk will walk the audience through the process of building of a biocontainment unit, including planning, design, policy/ protocol development and training of staff, with a focus on the infection prevention aspects to ensure staff safety. Potentially highly infectious specimen handling will also be discussed. Objectives: At the completion of the presentation, the audience will be able to:

Explain why it is critical to proactively plan, develop policies, train staff and ensure they are competent prior to caring for a patient with a highly infectious disease such as Ebola

Recognize some critical aspects of safe handling of patient specimens from a patient with a highly infectious disease

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Retire Right from Johns Hopkins


Barbara Fowler and Meg Stoltzfus Lifespan Services Managers Johns Hopkins Medical Institutions


Description: Recent research shows that the process of actively planning for life’s changes increases satisfaction in retirement years. Join staff from the Office of Work, Life and Engagement to learn how to develop a vision for your retirement and avoid common pitfalls. This non-financial retirement planning workshop is appropriate for faculty and staff within 10-15 years of retirement. Objectives: At the completion of the presentation, the audience will be able to:

Articulate issues that may be encountered in retirement

Use tools from this session to work effectively with your partner/family on your retirement vision

Identify resources available to help with creating/honing your retirement vision

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Lyme Disease: Understanding This 'Tick'ing Time

Bomb


J. Judd Fite, MD, MBA Resident Physician, PGY4 Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Immunology Target Audience: All are welcome

Description: This presentation will cover the biology of the causative agent of Lyme disease. We will discuss the clinical presentation of Lyme disease as well as the diagnostic algorithm and laboratory testing methods used at The Johns Hopkins Hospital. In addition, we will discuss the rates and causes of possible false positives in the laboratory diagnosis of Lyme disease. Objectives: At the completion of the presentation, the audience will be able to:

Identify the clinical manifestations of Lyme disease

Describe the laboratory testing algorithm for diagnosis of Lyme disease

Explain some of the pitfalls in the diagnosis of Lyme disease

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The Past, Present and Future of HIV Prevention

Trials Network Clinical Trials


Estelle Piwowar-Manning, MT(ASCP), SI Deputy Director, HIV Prevention Trials Network Laboratory Johns Hopkins University School of Medicine

Paul Richardson, MSc Senior QA/QC Coordinator Johns Hopkins University School of Medicine

Yaw Agyei, MPH, BS, MT(ASCP) International Lab QA/QC Coordinator Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Research Target Audience: All are welcome

Description: The HIV Prevention Trials Network (HPTN) is a worldwide collaborative clinical trials network that develops and tests the safety and efficacy of interventions designed to prevent and treat the transmission of HIV. The Laboratory Center for the Network is based in the Johns Hopkins Pathology Department. During this session we will discuss the history of HPTN trials and how the success of these trials has influenced the design of current and future trials. Objectives: At the completion of the presentation, the audience will be able to:

Accept that HIV is a preventable disease

Advocate that HIV prevention is necessary

Identify the challenges laboratories face in resource limited countries

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11:00a-12:00p Room: TBA

Common Brain and Eye Specimens and Disease


Charles G. Eberhart, MD, PhD Professor of Pathology, Ophthalmology, and Oncology Director of Neuropathology and Chief of Ophthalmic Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Histology/ Surgical Pathology Target Audience: All are welcome

Description: Overview of the specimens which commonly come from ophthalmologists and neurosurgeons, including discussions of specimen processing and common diagnoses. Objectives: At the completion of the presentation, the audience will be able to:

Discuss issues which can arise when processing ophthalmic specimens

Discuss issues which can arise when processing neurosurgical specimens

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11:00a-12:00p Room: TBA

Roman Vishniac: The Curious Microscopist


Norm Barker, MA, MS, RBP, FRPS Professor of Pathology & Art as Applied to Medicine Director of Pathology Photography and Graphic Arts Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: General/History Target Audience: All are welcome

Description: Roman Vishniac was one of the top scientific photographers of the 20th century. He is best known for his documentation of Eastern European Jewish life before the Holocaust. Vishniac’s photography career spanned over 60 years and his early contributions to the field of scientific photography date back to the 1940s. Today he is widely recognized as a pioneer in the field of photomicroscopy and 16 mm films with the microscope. In the early 1960s Vishniac received a grant from the National Science Foundation to produce a series of films called the "Living Biology Series," which were shown in college biology classes throughout the U.S. His long, interesting, and sometimes controversial adventures will be discussed. Objectives: At the completion of the presentation, the audience will be able to:

Appreciate the contributions Roman Vishniac made to the field of scientific filmmaking

Enjoy the history of one of the top social documentary and scientific photographers/filmmakers of the 20th century

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11:00a-12:00p Room: TBA

Current and Future Methods for Identification of

Fungi


Heather Miller, MHS, M(ASCP)CM Research Specialist, Clinical Microbiology The Johns Hopkins Hospital

Level of Instruction: Basic Category: Microbiology/Molecular Target Audience: All are welcome

Description: The first half of the talk will cover the methodologies currently employed at the Johns Hopkins Mycology Laboratory for the identification of both yeasts and filamentous fungi. The second half of the talk will cover new technologies that we have worked with in the Mycology Research Laboratory and how they may be applied to a clinical lab setting. Objectives: At the completion of the presentation, the audience will be able to:

Summarize methods of identifying yeasts and molds currently used in the Clinical Mycology Laboratory

Explain at least three new methods of identifying yeasts and molds that are under review in the Mycology Research Laboratory

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Deadlines, Distractions, and Dinner: Managing Your

Work-Life Effectiveness



Ian Reynolds Director, WorkLife and Community Programs Johns Hopkins Medical Institutions


Description: Today’s workforce struggles to effectively manage the growing pressures and responsibilities of both work and personal lives. As a result, intersections of work and life can divert our time and attention in ways that make us feel out of balance and ineffective. Join staff from the Office of Work, Life and Engagement to learn strategies for managing the boundaries between work and personal lives, making choices and trade-offs that lead to higher productivity, and living and working to your fullest potential. Objectives: At the completion of the presentation, the audience will be able to:

Identify barriers to effectiveness

Apply a time-management technique to assess how and where your time is being spent

Apply techniques to re-balance how and where you choose to spend your time

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Microbiology of Selected Infectious Diseases That

Changed History


Paula C. Mister, MS, MT, SM(ASCP)CM Education & Development Coordinator, Clinical Microbiology The Johns Hopkins Hospital

Level of Instruction: Basic Category: Microbiology/History Target Audience: All are welcome

Description: A look at selected infectious diseases from microbiological and historical perspectives—can knowledge learned from the past be used to tackle some of the infectious disease challenges of today? Objectives: At the completion of the presentation, the audience will be able to:

Briefly describe the microbiology and epidemiology of selected infectious diseases

Explain why these diseases are historically important—what lessons were learned, what advancements in medicine ensued?

Reflect on a few of the current challenges in infectious disease—can knowledge from past experience be applied to deal with them, and what are roadblocks remaining to their elimination?

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Tumor Immunology of Gastrointestinal Cancer: A

Pathologist’s View


Robert A. Anders, MD, PhD Associate Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Immunology/Histology/Surgical Pathology Target Audience: All are welcome

Description: This presentation will focus on how the anatomic pathologist can influence the development of novel and successful cancer treatment. Objectives: At the completion of the presentation, the audience will be able to:

Explain the role of anatomic pathology in driving cancer research

Describe the importance of human tumor samples in patient prognosis and prediction of response therapy

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Proteomics and Glycoproteomics Research: What

We Now Know


Hui Zhang, PhD Associate Professor of Pathology, Clinical Chemistry Division Johns Hopkins University School of Medicine Director of Mass Spectrometry Core Facility, Center for Biomarker Discovery and Translation

Level of Instruction: Intermediate Category: Clinical Chemistry Target Audience: All are welcome

Description: Carbohydrates attached to proteins are glycoproteins that constitute a highly interesting class of proteins for clinical and biological research due to the fact that many protein therapeutics and their targets are glycoproteins. Comprehensive characterization is complementary to genomic, proteomic, and functional data and plays crucial roles for the understanding of the biologic functions of glycoproteins. Objectives: At the completion of the presentation, the audience will be able to:

Describe glycoproteins

Summarize analytical methods for carbohydrates and proteins

Explain the molecular diversity of glycoproteins from modification of carbohydrates

Identify the carbohydrate contribution to specificity of disease detection

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Mental Multitasking, Memory Retrieval, and

Learning


Deirdre D. Parsons, MS, MT(ASCP)SBB Assistant Professor and Program Director, Department of Medical & Research Technology University of Maryland School of Medicine

Harry F. Wandell, MEd, MT(ASCP) Assistant Professor, Department of Medical & Research Technology University of Maryland School of Medicine

Level of Instruction: Basic Category: General/Education Target Audience: All are welcome

Description: This session will provide an overview of the physiology of learning as applied to memory encoding and retrieval, and mental multitasking. Recent research focusing on the impact of electronic devices on memory will be addressed. Audience participation will include activities that will test their memory skills. Objectives: At the completion of the presentation, the audience will be able to:

Describe the physiologic process of learning

Discuss the key factors that contribute to effective long-term memory

Explain the impact of multitasking on encoding memories and mental recall

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3:30p-4:30p Room: Tilghman Auditorium

Leaving a Legacy: Rapid Autopsies for Research


Jody E. Hooper, MD Director of Autopsy Director, Legacy Gift Rapid Autopsy Program Assistant Professor of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Autopsy/ Research Target Audience: All are welcome

Description: Autopsies today are performed for many purposes that go beyond investigation of causes of death. Besides evaluation of disease course and treatment, education of trainees, and supplying information for families, some autopsies today are performed specifically for research. Rapid research autopsies are completed to obtain tumor and normal tissue which has been utilized in creating cell lines and new living animal models, DNA and RNA sequencing, protein, and other studies. Large amounts of tissue can be taken at autopsy in multiple areas of tumor spread and genetic and other comparisons can be made in a way that cannot be done during life. These autopsies represent a unique chance for families and pathologists to contribute to the future of cancer research. Case examples will be given to show types of research and impact of participation. Objectives: At the completion of the presentation, the audience will be able to:

Identify purposes for autopsy besides investigation of causes of death

Describe unique opportunities created by sampling postmortem tissue

Appreciate how contributions to research can impact families of deceased patients

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Thursday, October 27, 2016 8:00a-3:30p: Registration (Turner Concourse)


Phlebotomy Case Review: Wrist Veins at Work - Do

Not Enter


LaVerne P. Farrar, BS, PBT(ASCP) Owner and Instructor All About The Blood Phlebotomy Resources

Level of Instruction: Intermediate Category: Phlebotomy/Safety Target Audience: All are welcome

Description: Presentation of most recent expert witness deposition and case study of a phlebotomy-related malpractice case involving attempted blood specimen collection from a wrist vein. Objectives: At the completion of the presentation, the audience will be able to:

Identify anatomical structures of the inside of the wrist which support non-use of the veins located in this area

Describe both legal and patient safety concerns related to attempting blood specimen collection from the inside of the wrist

Review CLSI guidelines of acceptable veins for blood specimen collection

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Thursday, October 27, 2016 8:30a-9:30a Room: TBA

Cancer-Associated Thrombosis: Trousseau's

Syndrome Revisited


Gang Zheng MD, PhD Assistant Professor of Pathology Associate Director, Hematology Laboratory Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Hematology Target Audience: All are welcome

Description: Cancer patients commonly demonstrate activation of coagulation, and venous thromboembolism can present as an early finding of cancer. Thrombosis is the second most common cause of death in outpatients with cancer, after the cancer itself. There are many pathophysiological mechanisms by which cancer and thrombosis are linked. Objectives: At the completion of the presentation, the audience will be able to:

Describe the risk factors of thrombosis for cancer patients

Explain the pathophysiological mechanisms for cancer-associated thrombosis

Summarize the epidemiology of cancer-associated thrombosis

Describe the potential biomarkers for venous thromboembolism in cancer patients

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Thursday, October 27, 2016


Giving and Receiving Feedback


Anne Moore, MA Senior Talent Management Consultant Organization Development and Effectiveness Johns Hopkins University


Description: The feedback we receive can open opportunities for both personal and professional growth and development. When done well, those receiving feedback are more likely to listen non-defensively and use the information to adjust behaviors and/or develop skills. In this session, we will discuss and practice the skills necessary to give and receive both constructive and positive feedback in a way that maintains relationships and helps to increase performance. Objectives: At the completion of the presentation, the audience will be able to:

Define feedback Describe how effective feedback can be used to assist in

development

Evaluate your own role in giving and receiving feedback

Apply a feedback model

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Zika and the Blood Supply


Evan M. Bloch, MD, MS Assistant Professor of Pathology Associate Director, Transfusion Medicine Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Blood Bank Target Audience: All are welcome

Description: This presentation will address the response to emerging infectious diseases from a blood transfusion safety perspective, using Zika virus as a model. Objectives: At the completion of the presentation, the audience will be able to:

Describe the variables that decide implementation of a new screening test

Characterize the risk of Zika to the blood supply

List possible mitigation strategies against emerging infectious diseases in general

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Who Cares about Renal Biopsies?


Serena M. Bagnasco, MD Associate Professor of Pathology Director, Renal Biopsy Service Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: Histology/Surgical Pathology Target Audience: All are welcome

Description: The presentation is intended as a general overview of the kidney biopsy as a diagnostic tool in the diagnosis of kidney disease. The lecture will cover basic technical aspects of processing a kidney biopsy in the pathology lab and will provide a basic introduction of the different type of renal diseases in native and transplanted kidneys where a kidney biopsy is crucial for diagnosis. Objectives: At the completion of the presentation, the audience will be able to:

Explain how the tissue obtained with a kidney biopsy can be processed and examined for diagnostic purposes

Identify the main type of kidney diseases where a biopsy can provide diagnostic information

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How Big of an Impact Are You Making on the

Environment, Both at Work and Home?


Karen Wittler Surgical Pathology The Johns Hopkins Hospital

Kelsey Hallowell Greening Facilitator Johns Hopkins Sustainability

Laura Armstrong Sustainability Coordinator Maryland Department of the Environment


Description: This session will cover efforts being made to apply environmentally sound practices ranging from your work to your home, from the laboratory to The Johns Hopkins Hospital to the State of Maryland. They will highlight best environmental practices and the impact that you can make on your community in your everyday actions. Objectives: At the completion of the presentation, the audience will be able to:

Identify efforts that are being made in the laboratories to promote recycling and reducing the impact of hazardous waste on the environment

Explain what the Hospital is doing to promote sound environmental practices to benefit patients, staff and the community

Describe what the State of Maryland is doing to encourage environmental best practices

38

Thursday, October 27, 2016 11:00a-12:00p Room: TBA

Bones and Bone Disease in Art


Edward McCarthy, MD Professor of Pathology, Surgical Pathology Johns Hopkins University School of Medicine

Level of Instruction: Basic Category: General/History Target Audience: All are welcome

Description: This is an overview of how bones and bone diseases have been depicted in art. First, many artists have captured either intentionally or unintentionally people with skeletal disorders in their paintings. Second, many doctors—some very famous—have also been very talented painters. (Does creating art increase powers of observation and make better doctors?) Third, many artists with bone disease have been influenced by their disease in doing their art. Fourth, some artists have depicted bone in an artistic style implying that bones are beautiful and worthy of being art. The relationship between the practice of medicine and the practice of art will be discussed. Objectives: At the completion of the presentation, the audience will be able to:

Name three artists who had bone disease

Relate how the bone disease affected the artists’ work

Name several bone diseases that are depicted in an art museum

39

Thursday, October 27, 2016 11:00a-12:00p Room: TBA

The Role of Prescription Drug Labels in Preventing

Adverse Drug Interactions


Ventzi Hristova, PhD Clinical Chemistry Fellow Johns Hopkins University School of Medicine


Description: The lecture will focus on the significance of prescription drug labels in identifying activities and products that present a high risk for adverse drug interactions. Functional and physical properties of specific drugs will be discussed with respect to their activity and how it can be impaired by known drug interactions, leading to detrimental health complications. Patient cases will be used to illustrate the importance of compliance with prescription drug instructions and emphasize the consequences of adverse drug interactions. Objectives: At the completion of the presentation, the audience will be able to:

Explain why certain prescription drugs have more stringent instructions/directions than others

Appreciate the importance of compliance with prescription drug labels and be aware of common adverse drug interactions that are easily preventable

40

Thursday, October 27, 2016 1:00p-2:00p Room: TBA

Living Mindfully



Ian Reynolds Director, WorkLife and Community Programs Johns Hopkins Medical Institutions


Description: Mindfulness is the act of living in the present moment. As we race through our busy days, most of us spend our time rehashing the past and worrying about the future instead of being fully present in our tasks and our relationships. Studies on mindfulness have shown that it can boost our immune system, increase positive emotions, and decrease stress. Join staff from the Office of Work, Life and Engagement for an experiential workshop to learn about the benefits of mindfulness and how to incorporate this practice into your life. Objectives: At the completion of the presentation, the audience will be able to:

Define mindfulness and list its health benefits

Utilize tools from the workshop to incorporate mindfulness into their daily lives

41


Next Generation Assays for Molecular Pathology


Joel J. Credle, PhD Fellow, Department of Pathology Johns Hopkins University School of Medicine

Level of Instruction: Intermediate Category: Molecular Target Audience: All are welcome

Description: The collection and preservation of tissue samples is a routine part of clinical disease management. Yet, available assays that can work with such samples suffer from low throughput and low multiplexing capabilities. Many new molecular assays currently in development are highly multiplexed with massively parallel capabilities. These diagnostic methods are capable of genome-wide transcriptome analysis, unbiased parallel detection of pathogens, and targeted recovery and analysis of subpopulations of specific cell groups. Objectives: At the completion of the presentation, the audience will be able to:

Describe the limitations inherent to clinical pathology samples

Explain how next generation assays are used in: gene expression analysis, pathogen detection, determining therapy efficacy and guidance

Identify current next generation assays and companion diagnostic test in the following categories: FDA approved; research use only (RUO); and laboratory-developed test (LDT)

42

Thursday, October 27, 2016


The Evaluation of Chronic Kidney Disease


Sumeska Thawarajah, MD Assistant Professor, Department of Nephrology Johns Hopkins University School of Medicine


Description: This presentation will be a review of chronic kidney disease diagnosis and management. Objectives: At the completion of the presentation, the audience will be able to:

Describe the diagnosis and evaluation of chronic kidney disease

Identify the testing needed for diagnosing chronic kidney disease and evaluating its etiology

43


Storytelling as a Professional Tool


Siyade Gemechisa Instructional Designer Johns Hopkins University Learning Solutions


Description: Storytelling can be a powerful professional tool for leaders, career development, and managing teams. By using your authentic voice to convey an idea or message, you can motivate and inspire your audience. Because stories are inherently linear while stimulating the imagination, they cause both the left linear brain and the right imaginative brain to become engaged, resulting in a message or an idea that sinks in with your audience. Whether you are leading a new initiative, expressing your career aspirations, or building rapport with your team, storytelling can be one of the most effective tools for engaging your audience, articulating your goals, or building a strong work team. Objectives: At the completion of the presentation, the audience will be able to:

Identify the components of an effective story

Convey a meaningful message or idea to an audience using a story

44


Current Methods and Research for Susceptibility

Testing of Multi-Drug Resistant Mycobacteria


Matthew Schwartz BS, M(ASCP) Clinical Laboratory Scientist III, Clinical Microbiology The Johns Hopkins Hospital

Level of Instruction: Intermediate Category: Microbiology/Molecular Target Audience: Technologists, Leads, Supervisors, Managers

Description: Learn about the growing problem of multi-drug resistant mycobacteria and what the clinical laboratory is doing to help combat the growing problem given our dwindling arsenal of antibiotics. Hear about current and upcoming research into new drugs and methods for testing and treatment of mycobacteria. Objectives: At the completion of the presentation, the audience will be able to:

Explain why multidrug resistant mycobacteria is a problem

Describe the different methods used to test for susceptibilities when dealing with mycobacteria

Describe what new and old drugs are available for treating multi-drug resistant mycobacteria

45

Fourth Annual Pathology

Educational Symposium Schedule at a Glance

Color Key:

General Chemistry Research

Surgical Pathology Hematology Molecular

Blood Bank Microbiology Quality Assurance

Cytology Immunology Phlebotomy

Poster Session: Poster presentations will be available for the duration of the Symposium and will allow attendees to receive additional P.A.C.E.® Continuing Education credit. Questions must be answered for a minimum of five posters, and a minimum passing score of 80% must be achieved. No partial credits can be awarded, and answers must be turned in by November 11, 2016.

Located in the Lower Turner Concourse Examples:

Questions answered for 5 posters with 80% receive 1.0 CEU. Questions answered for 10 posters with 80% receive 2.0 CEU.

Pathology Symposium Committee

Chairs: Lorraine Blagg and Vanessa Rodas-Eral

Maria Barata Alexis Jones Karen Bordenet Renata Karlos Chris Cavelli Kurt Michael Barbara Detrick Paula Mister Linda Gluck Nancy Nath Monica Gray Suzy Nicol Tammy Heacock Doris Pendergrass Rosemary Hines Eunhee Rim Christine Hostetter Jo Shim Brittney Howard Marian Turpin

Debbie Williams

46

Lun

ch

(We

st Ro

om

)

Ro

om

#3

Ro

om

#2

Ro

om

#1

Re

gistra

tion

(Low

er Tu

rne

r Co

nc

ou

rse)

Tue

sda

y

Oc

tob

er 2

5, 2

01

6

Re

gistra

tion

& P

oste

r Pre

sen

tatio

n 8

a-3

:30

p

8:0

0

AM

Wo

men

Wh

o

Help

ed

Make

Ho

pkin

s G

reat

8:3

0 A

M

Serolo

gic Tech

niq

ues

Imm

un

oh

e-m

atolo

gy*

Prin

ciples o

f Breast C

ancer C

are

(2h

r)

Gu

ns, K

nives,

and

Ro

tting

Co

rpses

9:4

5 A

M

Prean

alytical V

ariables in

Clin

ical Ch

emistry

Testing

Sex and

the

Single

Ch

rom

oso

me

* (web

cast

from

All

Ch

ildren

’s)

11

:00

AM

Lun

ch

12

:00

PM

Intro

du

ction

to Leu

kemia

& Lym

ph

om

a

Wh

at's Special

abo

ut Sp

ecial M

icroto

my?

Clin

ical and

Lab

orato

ry

Asp

ects of

HLA

1:0

0 P

M

I SPY a

Labo

ratory

No

n-

Co

mp

liance!

Rap

id

An

timicro

bial

Suscep

tibility

Testing

Ho

w H

osp

itals

Get P

aid*

2:1

5 P

M

Wh

en

Hu

man

s

Stud

y H

um

an: A

Histo

ry*

3:3

0 P

M

Se

co

nd

An

nu

al P

ath

olo

gy

Ed

uc

atio

na

l Sy

mp

osiu

m

Sc

he

du

le a

t a G

lan

ce

Fo

urth

An

nu

al P

ath

olo

gy

Ed

uc

atio

na

l Sy

mp

osiu

m

Sc

he

du

le a

t a G

lan

ce

47

Lun

ch

(We

st Ro

om

)

Ro

om

#3

Ro

om

#2

Ro

om

#1

Re

gistra

tion

(Lo

we

r Turn

er C

on

co

urse

)

We

dn

esd

ay

Oc

tob

er 2

6, 2

01

6

Re

gistra

tion

& P

oste

r Pre

sen

tatio

n 8

a-3

:30

p

8:0

0

AM

Mass

spectro

metry-

based

MR

M

Assays

An

xiety and

Dep

ression

in

Ad

olescen

ts*

Infectio

n C

on

trol

for

Bio

con

tainm

ent

Un

it

8:3

0 A

M

Retire R

ight fro

m

Joh

ns H

op

kins

Lyme D

isease:

'Tick'ing Tim

e B

om

b*

HIV

P

reventio

n

Trials N

etwo

rk

Clin

ical Trials

9:4

5 A

M

Brain

and

Eye Sp

ecimen

s

and

Disease

Meth

od

s for

Iden

tification

o

f Fun

gi

Ro

man

V

ishn

iac: The

Cu

riou

s M

icro-

scop

ist

11

:00

AM

Lun

ch

12

:00

PM

Dead

lines,

Distractio

ns,

and

Din

ner

Micro

bio

logy

that C

han

ged

Histo

ry*

1:0

0 P

M

Tum

or

Imm

un

olo

gy of

GI C

ancer

Pro

teom

ics and

Glyco

pro

te-o

mics

Men

tal Mu

lti-taskin

g

2:1

5 P

M

Leaving a

Legacy: Rap

id

Au

top

sies

3:3

0 P

M

Fo

urth

An

nu

al P

ath

olo

gy

Ed

uc

atio

na

l Sy

mp

osiu

m

Sc

he

du

le a

t a G

lan

ce

48

Lun

ch

(We

st Ro

om

)

Ro

om

#3

Ro

om

#2

Ro

om

#1

Re

gistra

tion

(Lo

we

r Turn

er C

on

co

urse

)

Thu

rsda

y

Oc

tob

er 2

7, 2

016

Re

gistra

tion

& P

oste

r Pre

sen

tatio

n 8

a-3

:30

p

8:0

0

AM

Can

cer-

Asso

ciated

Thro

mb

osis

Ph

lebo

tom

y C

ase Review

:

Wrist V

eins at

Wo

rk - Do

No

t

Enter

Givin

g and

Receivin

g Feed

back

8:3

0 A

M

Wh

o C

ares abo

ut

Ren

al Bio

psies?

Zika and

the

B

loo

d Su

pp

ly

Makin

g An

Imp

act On

the

Enviro

nm

ent

9:4

5 A

M

Prescrip

tion

Dru

g & A

dverse

Reactio

ns

Bo

nes an

d

Bo

ne D

isease

in A

rt*

11

:00

AM

Lun

ch

12

:00

PM

Living

Min

dfu

lly

Next

Gen

eration

Assays

Mo

lecular

Path

olo

gy*

1:0

0 P

M

Storytellin

g as a Pro

fession

al

Too

l (2

hr)

2:1

5 P

M

Evaluatio

n

of C

hro

nic

Kid

ney

Disease*

Suscep

tibility

Testing o

f M

ulti-D

rug

Resistan

t M

ycob

acteria

3:3

0 P

M

Fo

urth

An

nu

al P

ath

olo

gy

Ed

uc

atio

na

l Sy

mp

osiu

m

Sc

he

du

le a

t a G

lan

ce

49

REGISTRATION

Name: ______________________________ Badge #:___________________ Email: _________________________________________________________ JHM Entity: __________________ Division: ___________________________ Supervisor/Manager: _____________________________________________

Selection for the Sessions: Employee: This is a preliminary schedule and is subject to change. To aid us in planning and assigning rooms for each talk, please register at

http://pathology.jhu.edu/department/training/symposium.cfm. You must also register for lunch if you wish to have a lunch available to you only on days you are attending. Registration deadline is October 14, 2016. You may be required to get Supervisor approval before registering.

Are you interested in Volunteering for this event?

http://signup.com/go/wcmPY5 Examples: Session Moderator, Registration, Room Lead, Lunch, etc.

TUESDAY, OCTOBER 25, 2016

Time Course

8:30-9:30a Women Who Helped Make Hopkins Great 612-302-16 9:45-10:45a Serologic Techniques Immunohematology 612-303-16 9:45-10:45a Guns, Knives, and Rotting Corpses 612-322-16 9:45-11:45a Principles of Breast Cancer Care (2hr) 612-304-16 11:00-12:00p Sex and the Single Chromosome 612-336-16 11:00-12:00p Preanalytical Variables in Clinical Chemistry612-305-16 12:00-12:45p Lunch 1:00-2:00p Introduction to Leukemia and Lymphoma 612-342-16 1:00-2:00p What's Special about Special Microtomy? 612-307-16 1:00-2:00p Clinical and Laboratory Aspects of HLA 612-337-16 2:15-3:15p I SPY a Laboratory Non-Compliance! 612-308-16 2:15-3:15p Rapid Antimicrobial Susceptibility Testing 612-310-16 2:15-3:15p How Hospitals Get Paid 612-309-16 3:30-4:30p When Humans Study Humans: A History 612-316-16


http://signup.com/go/wcmPY5

50

REGISTRATION (continued)

WEDNESDAY, OCTOBER 26, 2016

Time Course

8:30-9:30a Anxiety and Depression in Adolescents 612-311-16 8:30-9:30a Mass Spectrometry-based MRM assays 612-312-16 8:30-9:30a Infection Control for Biocontainment Unit 612-338-16 9:45-10:45a Retire Right from Johns Hopkins 612-313-16 9:45-10:45a Lyme Disease: 'Tick'ing Time Bomb 612-320-16 9:45-10:45a HIV Prevention Trials Network 612-330-16 11:00-12:00p Brain and Eye Specimens and Disease 612-315-16 11:00-12:00p Roman Vishniac: The Curious Microscopist 612-335-16 11:00-12:00p Methods for Identification of Fungi 612-333-16 12:00–12:45p Lunch 1:00-2:00p Deadline's Distractions and Dinner 612-317-16 1:00-2:00p Microbiology that Changed History 612-318-16 2:15-3:15p Tumor Immunology of GI Cancer 612-319-16 2:15-3:15p Proteomics and Glycoproteomics 612-314-16 2:15-3:15p Mental Multitasking 612-334-16 3:30-4:30p Leaving a Legacy: Rapid Autopsies 612-321-16

THURSDAY, OCTOBER 27, 2016

Time Course

8:30-9:30a Phlebotomy Case Review 612-339-16 8:30-9:30a Cancer-Associated Thrombosis 612-323-16 8:30-9:30a Giving and Receiving Feedback 612-306-16 9:45-10:45a Zika and the Blood Supply 612-324-16 9:45-10:45a Who Cares about Renal Biopsies? 612-325-16 9:45-10:45a Making An Impact On the Environment 612-341-16 11:00-12:00p Bones and Bone Disease in Art 612-326-16 11:00-12:00p Prescription Drug & Adverse Reactions 612-327-16 12:00–12:45p Lunch 1:00-2:00p Living Mindfully 612-328-16 1:00-2:00p Next Gen. Assays Molecular Pathology 612-329-16 2:15-3:15p Evaluation of Chronic Kidney Disease 612-331-16 2:15-4:15p Storytelling as a Professional Tool (2 hr) 612-332-16 3:30-4:30p Multi-Drug Resistant Mycobacteria 612-340-16

fourth annual pathology educational...

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