,.., flLE COPY

ecor U . 5 . D EPARTMENT OF'

HEALTH, E DUCATION , ANO W ELF'ARE October 8, 1974

Vol. XXVI, No. 21

NCI Breast Cancer Task Force Raises Questions On Surgical Treatment

Last Monday (Sept. 30), scien­tists from many parts of the U.S. who are involved in cancer re­search attended a Report to the Profession Meeting of the Nation­al Cancer Institute's Breast Cancer Task Force.

The Task Foree and its partici­pating researchers presented six topics at the all-day meeting in the Masur Auditorium. They were: epidemiology, virology, experimen­tal biology, diagnosis, and treat­ment.

Intensive Research Undertaken

The report pointed out that be­cause traditional surgical treat­ment for breast cancer has been questioned, intensive research by the Task Force has been undertak­en to improve the d iagnosis and treatment of the disease.

It was further explained that Task Force findings do not repre­sent major breakthroughs and <that more time and study are required for do,cumenting long-term results.

But there is also evidence that "it should be posMble to improve substantially both the cure and survival rates from cancer of the breast, and with less di!>fi.guration than results from radical mastec­tomy."

Early Detection Important Early detection~before the can­

cer has spread to other parts of the body - increases ,a patient's chance for long-term survival and cure.

Patients with non-cancerous arm­pit lymph nodes when breast can­cer is diagnosed have a 75 percent, 5-year survival rate; 65 percent of these patients are alive after 10 years.

Screening Program Sponsored Women with breast cancer in

the axillary (armpit) nodes have about a 50 percent 5-year survival rate; about 25 percent will live 10 years.

NCI and the American Ca,ncer Society are jointly sponsoring a breast cancer screening demonstra­tion program which involves 27 projects. Up to 270,000 women, 35

(Seo TASK FOROPJ, Page 6)

NINDS Data Contributes to Approval of Drug Tegretol for Controlling Epilepsy; Used Abroad

Because of an anticonvulsant drug-Tegretol-which has just been made available, the control of epileptic seizures may soon be a reality for thousands of epilepsy sufferers who are unresponsive to standard drug therapy.

1st Advance in 20 Years This is the first new anticonvul­

s-ant drug that has b e e n made available since 1960, and it is the first major advance in 20 years in the long-term treatment of grand mal and psychomotor epilepsy.

Tegretol, a trade name for the compound carbamazepine, has been used to treat epilepsy in other countr ies for over a decade, but has been authorized in the United States only for treating trigeminal neuralg;ia, a painful face ailment.

It has ,been proved effective in controlling complex partial (temp­oral lobe or psychomotor) and gen­eralized tonic-clonic (grand mal) seizures and has now been approv­ed for prescription use by the F ood

and Drug Administration. CIBA - GEIGY pharmaceutical

company, developer of the drug, was assisted in evaluating the agent by the National Institute of Neurological Diseases and Stroke.

NINOS provided three studies of Tegretol under research contract, and clinical data from one of the contracts were used in the appli­cation for approval.

This is the first time that a Fed­eral health research agency and a d1·ug manufacturer have coopera­ted in providing data for the eval­uation of an epilepsy drug.

Th e victims who will benefit most from carbamazepine will be those whose seizures a re uncon­trolled, or only partially controlled with standard drugs such as di­phenylhydantoin (Dilantin), pheno­barbital or primidone ('Mysoline).

With improved or total control of seizures, these people will have a -better chance for a normal life.

The NINDS studies which sup­(Sce TEGRPJTOL, Paoe J)

Dr. Robert S. Stone, NIH Director, welcomes Dr. D. D. Venediktov, Deputy Ministe r of Health, USSR, when he arrived at NIH on Sept. 17. Dr Vencdik­tav, who was accompanied by Dr V. F. Ste phonov, Counselor on Medicine of the Russian Embassy, discussed with Dr. Stone the medical research thot is being conducted in his country and in the U.S. Dr, DeWitt Stetten, Jr., NIH Deputy Director for Science, and Dr. Oliver M. Karshin, Director of the US­USSR Health Exchange Program, Office of International Hea lth, also took part in the informal meeting.

NATIONAL INSTITUTES OF' HEALTH

Dr. Elizabeth F. Neufeld To Give Mider Lecture Tomorrow, Oct. 9, in CC

Before coming here, Dr, Neufeld con­ducted research ond lectured at the Unive rsity of California where she had received her Ph.D. She . is con­sidered a leading authority an human genetic diseases.

Dr. Elizabeth F. Neufeld, chief o.f the Section on Human Biochem­ical Genetics, National Institute of Arthritis, Metabolism, and Diges­tive Diseases, will pres·ent t he Sev­enth Annual G. Burroughs Mider Lecture tomorrow (Wednesday, Oct. 9) at 8:15 p.m. in the Masur Auditorium.

Dr. Neufeld's address, Inherited Lysosomal Disorders Studied in Cell Cultu1·e1 will present the work of her and her associates on a group of genetic diseases known as mucopolysaccharide storage disor­ders, of which the Hurler syndrome is the best known.

Uses Patients' Ce lls The biochemical basis of these

diseases was elucidate<l by using cultured cells derived fro m pa­tients.

The successful clinical applica­tion of some of her findings has brought about prenatal dia,gnosis of the mucopolysaccharidoses. As an outgrowth of her work, new possibilities for enzyme replace­ment therapy may emerge.

Members of t he scientific com­munity and the press ar e invited to attend the Mider Lecture.

Page 2 October 8, 1974- THE NIH RECORD

ecord Published biweekly at Bethesda, Md., by t he Publications and Reports Branch, Office of Information, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welfare, and circulated by request to interested writers and to investi­gators in the field of biomedical and related research. The content is reprintable without :!)ermission. Pictures are available on r equest. The NIH Record reserves the right to make corrections, changes or dele­tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare.

NIH Record Office ...... , ..... .. ....... ... .. .. Bldg. 31 , Rm. 28-03. Phone 49-62125

Editor .. ............... ... .. ....... .. . .. ................... ....... .... ...... ... .. .. .. Fronces W. Dov is Associate Editor ............................................................. ............... Foy Leviero

Staff Correspondents ADA, J udy F leisher; CC, Thalia Roland; DCRT, Joan Chase; DRG, Sue Meadows; DRR, J erry Gordon; DRS, Cora M. Sult; FIC, George Presson ; NCI, Carolann Hooton; NEI, Bonnie Friedman Spellane; NHLI, Bill Sanders; NIAID, Krin Kolsky; NIAMDD, Pat Gorman; NICHD, Kathy Kowalczyk; NIDR, Sue Hannon; NIEHS, E lizabeth Y. James; NIGMS, Wanda Warddell; NIMH, Betty Zubovic; NINDS, Carolyn Hol­stein; NLM, Fran Patrick.

Stohlman, Wife V,ictims Of Crash in Ionian Sea

Dr. Frederick Stohlman, Jr., who was a senior investigator at the National Institute of Arthritis, Metabolism, and Digestive Diseas­es between 1953 and 1963, and his wife, Bernadette, died Sept. 8 in a plane crash in the Ionian Sea off the coast of Greece.

Dr. and Mrs. Stohlman were en­route from Tel Aviv, where the prominent hematologist had pre­sented papers at the Congress of the International Society of Hema­tology, to another international conference in Naples.

Dr. Stohlman, 4-8, was world­renowned for his work in blood cell production.

Since 1965 he had been director of medicine and research at St. F)Jizabeth\s Hospital, Brighton, Mass., and also professor of med­icine at Tufts University School of Medicine.

Vasta Elected to Office of ACS, Chemical Information Division

Bruno M. Vasta, chief of Toxi­cology Information Services in the National Library of Medicine's Specialized Information Services, has recently been voted chairman­elect of the American Chemical Society's Division of Chemical In­formation.

He took office at the ACS meet­ings in Atlantic City on Sept. 10. Mr. Vasta will serve in that office for one year until 1976 when he will become chairman of the Division.

A memorial service for Dr. Stohlman was held at the George­town Hospital Chapel on Sept. 21.

Friends may send donations to the Fred and Bernadette Stohlman Memorial Research Fund, Hema­tology Research Department, St. Elizabeth's Hospital, 736 Cam­bridge Street, Brighton, Mass. 02135.

The recent program in the Masur Auditorium during Asian-Ame rican Cultural Week featured Korean folk dancing ond korate. Diminutive dancers from Woo Soon Lee's folk dancing group (I) perform the Korcon basket donce. Korote students from the Jhoon Rhee Koreon Karote studios (r) show the fine· points of the art of self-defense. The qualified students demonstrate how to break o board in two with the thrust of a foot.

It Took Walter Magruder 3 Months After Retiring to Really Leave the Campus

If you heard that Walter H. Magruder, National Institute of Allergy and I nfectious Diseases' executive officer, retired on June 28, but you thought you saw him recently in Bldg. 31 or walking around the grounds, you are right on both counts. "Wa:J,t'' Magruder retired in June after 40 consecutive years of Fed-

~\ ~,

How that Mr. Magruder has left NIH there ore plenty of things to kee p him busy. To name a few: fishing, golf, gardening, ond refinishing antiques.

era! service. However, he has re­mained on duty until a successor could be hired.

So, following a farewell lunch­eon on Sept. 27 attended by many of his associates and friends, Mr. Magruder's retirement was com­plete. As he said, " I don't know what I'm going to do, but I'm look­ing forward to i-t."

Actually, Mr. Magruder has a lot of t hings to keep him busy, including fishing, golf, gardening, reading, and short trips abroad or visiting friends in this country.

A native of Washington, D.C., he and his wife plan to stay in this area- at least for t he present. His son and family live in this area and his daughter and her husband are in Pennsylvania-close enough for frequent visits.

They Go Antiquing A good portion of Mr. Magru­

der's retirement time will be spent on one of his favorite hobbies­antiqu·es. He and his wife go to auctions and occassionally buy an unusual piece of f urniture or a set of chairs.

No state of disrepair is too seri­ous because Mr. Magruder enjoys repairing these items and then re-

finishing them. Walter Magruder's Federal ca­

reer began in January 1934 when he joined the staff of the National Recovery Administration as a young messenger. Later he became an auditor with the General Ac­cou.nting Office.

Worked in South America Then, in 1941 he took a job as

a government project officer with the War Department's Army En­gineers. That jo!b took him to South America where he was in­volved in the construction of lend­lease air ports in places like Brit­ish and French Guiana a.nd several West Indies islands. The iob also took ·him ,around the United States on similar projects.

In 1943, Mr. Magruder became Petty Officer Magruder in the U.S. Navy Construction Battalion and was stationed in the South Pacific. After the war, he was employed in the Washington, D.C. office of the War Assets Administration, first as a claims auditor and later

(Sec WA.l/ /'ER .lfAGRUDER, Paue 4)

Safety Tips for NIH

RADIQ\CT1Vrr'( .. · If.AV( IT

IN THE ~a! To assure that you are protected

from radiation contamination : • Wear a lab coat. • Wear disposable gloves and

change them frequently. • Monitor yourself for contam­

ination. • Immediately wash off con­

tamination with mild soap. • Guard against internal con­

tamination. Avoid breathing or in­gesting radioactive material, never pipette by mouth.

In the event of personal contam­ination, call Radiation Safety, Ext. 65774; after hours, call Guard Of­fice, Ext. 65685.

THE NIH RECORD October 8, 1974 Page 3

Four new librarians-each with a maste r's degree in library science--have joined NLM's Postgraduate Library Associate Training Program in Biomedical Communications. They are (I to r): Jan Farmer, Linda Baum, Virginia White, and Carolyn Davis. The curriculum includes lectures and seminars on NLM' s programs, independent research, and visits to area medical and research libra­ries. A brochure on the program is available through the NLM associate director for Library Operations. Address inquiries to Seldo Futrowsky or Cecil Quintal.

Metro Bus Offers New Cross-County Service: Stops at Clinical Center

A new Metro Bus route between the Beltway Plaza and Montgom­ery Mall, which stops at NIH, started Sept. 1 at the same time as the C-2 route between Wheaton Plaza and Montgomery Mall (see the ,VlH Uecord, Sept. 11).

On the J-2 cross-county route, direct service is provided between the Beltway Plaza, University of Maryland, Prince Georges' Plaza, Silver Spring, Rock Creek Forest, Bethesda, NIH, and Montgomery Mall.

The service operates hourly from 6 a.m. to 10 p .m., and is coordina­ted with the J-4 schedule to pro­vide a 30-minute interval between Bethesda and Silvm- Spring on weekdays and Saturdays.

The new bus travels the follow­ing route : Greenbelt Road, Balti­more Boulevard, Campus Drive, Adelphi Road, Belcrest Road, East­West Highway, first entrance to Prince ~orge's Plaza, and back to the East-West Highway.

Travels Circuitous Route From there the bus goes via Bel­

crest Road to Queens Chapel Road, Hamilton Street, Ager Road, East­West Highway, Ethan Allen Ave­nue, CaIToll Avenue, Philadelphia Avenue, Fenton Street, Sligo Ave­nue, Georgia Avenue, \ Vayne Ave­n u e, Pershing Drive, Fenton Street, and back to Wayne Avenue.

The route continues to Pershing Drive, Fenton Street, Colesville Road, 16th Street, East-West High­way, Washington Avenue, Grubb Road, Terrace Drive, Freyman Drive, Meadowbrook Lane, East­West Highway, Old Georgetown Road, and makes a right to Center Drive to t he Clinical Center.

NIH Stage Band Gives Concert

The NIH Sta.ge Band will pre­sent a concert for Clinical Center patfonts and NIH employees on Oct. 10. The performance, spon­sored by the CC Patient Activity Section, will begin at 7:30 p .m. in the Masur Auditorium.

The bus t h e n returns to Old Georgetown Road, continues on Democracy Boulevard, first road­way west of Bells Mill Road, Rock Spring Drive, Fernwood Road, Democracy Boulevard, Westlake Drive to Yiontgomery Mall, to ter­minal stand at curb between Ler­ner's sign and mall entrance, and returns over the same route.

Transfer connections are avail­able at many points to other routes serving most of Montgomery Coun­ty and the District of Columbia.

George E. Jarboe has been named e xecutive officer, Division of Research Grants. He will be the prinicipal staff advisor on DR.G's management activ­ities. Mr. Jarboe, who come to NIH in 1959 as a management intern, hod been se rving as director of the NIH executive secretariat. Before that posi­tion, he had held severa I othe r ad• ministrative posts here.

Hospital T earn Studies Drug Injection To Treat Hereditary Crippling Disease

By Klaudia M. Cox While standing in his crib at the State University Hospital in Brook­

lyn, Kyle Mulroy, who is 13 months old, suffered his fifth broken bone. Kyle was born with an hereditary crippling disease--osteogenesis imper­fecta. His bones are so soft and porous that the pressure of body weight when he is standing can cause them to frac­ture.

Kyle is the youngest patient in the hospi­tal's Gener al Clinical Research Center - sup­ported by the Division of Research Resources - who is receiving a synthetic version of cal­citonin, a hormone pro­duced by th e thyroid gland.

\

Dr. Salvador Castells, head of the four-mem­ber research t e a m studying the effective­ness of calcitonin in­jections as a treatment for osteogenesis imper­fecta, thinks that this chemical is a potential­ly safe, effective treat­ment to arrest the dis­ease and its devastat-ing consequences.

Kyle, the youngest patient in the hospital's ORR­supported General Research Ce nter, receives a synthetic version of calcitonin, a hormone pro­duced by the thyroid gland. Children who have rece ived this therapy may have a temporary growth spurt and show some increase in bone density.

"Bone tissue absorbs calcium from the blood stream to aid in calcification," Dr. Castells explain­ed. "Then the calcium is resorbed into the blood stream.

Disease Explained "In osteogenesis imperfecta, the

absorption process seems to wor k correctly. What is irregula1· is the resorption process, which is speed­ed up."

The calcium doesn't remain in the bone long enough for calcifi­cation and growth to occur before it is resorbed by the blood, Dr. Castells further stated.

Calcitonin, th e hormone which slows down the calcium resorption by the blood, is produced at a nor­mal rate but is not as effective as it should be in the osteogenesis im­perfecta victim. By giving excess doses of the synthetic calcitonin, the resorption process slows to a normal level.

In Dr. Castell's study, the hor­mone has increased positive calci­um balance and reduced bone turn­over in his patients. A notable ef­fect of the drug therapy is the ab­sence of adverse reactions, such as allergic re6ponses or toxic effects.

In its severest form, osteogenesis imperfecta congenita, symptoms are present at birth. The pressure of the amniotic flu id and the birth process can cause a child to be born broken, t\visted, and even fat­ally injured from fractures of the sku11 and other bones.

Other characteristics of the dis­ease that may appear include dwarfism, deafness due t o softness of the bones of the inner ear, and

an abnormality which causes the whites of the eye to be blue.

If symptoms become apparent when a child begins to stand and walk, as with young Kyle, the dis­ease is ca11ed osteogenesis imper­fecta tarda.

Some children who have received calcitonin ther apy seem to experi­enced a temporary growth spurt, break fewer bones, and show some increase in bone density.

If therapy continues to produce positive results, the standardized

(See DRUG INJECTION, Pauo 6)

Male Volunteers Needed For Heart Institute Study

The National Heart and Lung Institute requir es male volunteers for a study to de­termine the relationship of ur­inary steroids to myocardial infarctions.

Those in the following three categories may apply: (1 ) normal volunteers ,aged 35 to 50; (2) volunteers who have had a myocardial infarction, and (3) volunteers who have coronary artery disease (an­gina) but have had no myo­cardial infarction.

Patients who have h ad a documented hca.rt rittack are particularly needed.

Participation in the study will involve 24-hour urine col­lections and one blood speci­men for determining blood lipid pattern.

Volunteers may contact J une Moon, Ext. 61556, or Di-. An­gelo A. Licata, Ext. 66268.

Page 4

CC Employees Honored At Awards Ceremony

More tihan 300 employees of ,the Clinical Center received awards at the Third Annual Honor Awards Ceremony in the Masur Auditor­ium on Sept. 11.

Dr. Robert S. Gordon, Jr., OC Director, addressed the assembly and commended the recipients for their achievements.

Ove.r 100 individual and g,roup superior performance awards for outstanding contri'butions to t h e patient care program were given by Dr. Gordon, associate director Dr. Philippe V. Cardon, and execu­tive officer L. Earl Laurence.

EEO Achieveme nts Cited

EEO awards for work in behalf of that program were Teceived by Mar,garet E. Benson, Nursing De­partment; Clifford Moss, Office of Personnel Management; Dr. Paul J. Schmidt, chief of the Blood Bank Department, and Evelyn Walker, Social Work Department.

PHS commendation medals went to Dr. Gerald S. Johnston, chief, Nuclear Medicine Department; Alice E. Duncan, Nursing Depart­ment; Louise Boyer, Nutrition De­partment, and Margaret Lamson, Oftice of bhe Director.

TEGRETOL ( Oo11ti11ued /1·0,,. PaQ6 1)

plied the clinical d a t a for the drug's approval were irbtained dur­ing the last 3 ye•ars through con­tract-funded, dou.ble~blind trials at New Castle State Hospital in In­diana.

Other studies, not yet complete, are being done at the Lafayette Clinic, Detroit, Mich., and at the Umversity of Washington School of Medicine, Seattle.

Dr. J. Kiffin Penry, chief of NINDS's Applied Neurologic Re­search Branoh, and medical officer, Dr. James J. Cereghino, were proj­ect officers of the contracts.

ln discussing th e approval of carbamazepine for epilepsy, Dr. Penry said, "Since 1962, stringent proof of efficacy and safety has been required for new-drug ap­proval.

"Drug companies have been re­luctant to invest large sums of money for investigations of new drugs for epilepsy. Because NIN­OS is most interested in develop­ing better new epilepsy drugs we were most happy to participate in the evaluation of carbamazepine.

"Its addition to the 13 other drugs now marketed for treating the various types of epilepsy should stimulate drug-eompany in­terest in finding more good anti­convulsants."

An adult is one who has ceased to grow vertically but not horizon­tally.-A.non11mous.

October 8, 1974

WALTER MAGRUDER (Oo11ti1111ed fro,,. Page 2)

w a s chief collections officer for that office.

Then in rn48 he moved to the Atomic Energy Commission, event­ually serving as a program analyst in the Division of Biology and Medicine.

The year 1952 marked the be­ginning of Mr. Magruder's career at NIH. At that time, he became the fu·st •bud,get officer of the Na­tfonal Microbiological Institute.

Joined NCI in 1955

Three years later he joined the staff of the National Cancer Insti­tute, serving as administrative of­ficer of its Intramu,ral Research and Chemotherapy programs. In 1966 he returned to NIMD.

U would appear to be difficult to leave Federal service after such a long and active career. But, Mr. Magruder is quite philosophical about his retirement - "Most of the people I've 'g,rown up with' at NIH are leaving or have left, and I think it's my turn now."

That's where part of YOUR CFC con­tributions go--and a worthwhile cause it is! Edna Walke r, NIH cam­paign worker, visits a nursery school at the Cedar Lane Unitarian Church that is helped immeasurably through CFC funds. The school is sponsored by the Montgomery County Associa­tion for Retarded Citize ns. See page 8 for story and othe r photo.

Statistics Center Tells Resu Its Of Survey on Blood Pressure

A recent survey of blood pres­sure levels of a group of 6- to 11-year-olds by the National Center for Health Statistics indicated that systolic levels rose consistently with each y,ear of age.

There was no such consistent in­crease in diastolic pressures.

Girls' blood pressure levels, es­pecially systolic, were generally slightly higher than for boys.

Among adults, however, men g,enerally had higher levels than women through age 60.

I. NIH Visiting Scientists Program Participants

8/ 28 - Dr. Kenny S. Crump, U.S.A., Environmental Biometry Branch. Sponsor: Dr. David Hoel, NIE.HS, Research Triangle Park, N.C.

8/ 30-Dr. Uriel Bachrach, Israel, Laboratory of Biochemioal Gene­tics. Sponsor: Dr. Marshall Niren­berg, NHL!, Bg. 36, Rm. 1C27.

9/1- Dr. Michael D. P. Boyle, United Kingdom, Biology Branch. Sponsor: Dr. Tibor Borsos, NCI, Bg. 37, Rm. 2B15.

9/ 1---Jlr. Dan Eilat, Israel, La,b­oratory of Chemical Biology. Spon­sor: Dr. Alan Schechter, NIAMDD, Bg. 10, Rm. 9N321.

9/1-Dr. James W. Hu, Taiwan, Neurobiology and Anesthesiology Branch. Sponsor: Dr. Ronald Dub­ner, NIDR, Bg. 30, Rm. B2.

9/ 1-Dr. Michael A. Lett-Brown, United Kingdom, Biology Branch. Sponsor: Dr. Edward J. Leonard, NOI, Bg. 37, Rm. 2B21.

9/ 1-Dr. Hiroshi Maruta, Japan, Laboratory of Biochemistry. Spon­sor: Dr. Edward D. Korn, NHL!, Bg. 3, Rm. 318.

9/ 1-Dr. Shahjahan Kabir, Bang­ladesh, Laboratory of Microbiolo­gy. Sponsor: Dr. Joost Oppenheim, NIDR, Bg. 30, Rm. 322.

9/ 1- Dr. Setsuo Kuroda, Japan, Laboratory of Biological Structu.re. Sponsor: Dr. Marie Nyl-en, NIDR, Bg. 30, Rm. 209.

9/ 1-Dr. Ghiharu Nakai, Japan, Laboratory of Biomedical Sciences. Sponsor: Dr. Walter H. Glinsmann, NlCHD, Bg. 6, Rm. 312.

9/ 1-Dr. Nobuo Nemoto, Japan, Chemistry Branch. Sponsor: Dr. Harry V. Gelboin, NCI, Bg. 37, Rm. 3E24.

9/ 1-Dr. Anne-Marie Schmitt, Belgium, Immunology Branch. Sponsor: Dr. Gene Shearer, NCI, Bg. 10, Rm. 4B55.

9/ 1-Dr. Gabriella Zsilla, Hun­gary, Laboratory of Preclinical Pha1,macology. Sponsor: Dr. Er­minio Costa, NIMH, St. Eliza•beths Hospital.

Researcher From Fro nee

9/ 3 - Dr. Martine Canivet, France, Viral Leukemia and Lym­phoma Branch. Sponsor: Dr. Rob­ert Bassin, NCI, Bg. 41, Rm. 400.

9/ 3 - Dr. Erik Frandsen, Den­mark, Laboratory of Chemical Pharmacology. Sponsor: Dr. James R. Gillette, NHLI, Bg. 10, Rm. 8N117.

9/ 3-Uri Goldbourt, Israel, Bio­metrics Research Branch. Sponsor: Tavia Gordon, NHLI, Landow Bg., Rm. C841F.

9/ 3 - Dr. Thomas J . Pinnavaia, U.S.A., Laboratory of Chemical Physics. Sponsor: Dr. Edwin Beck­er, NIAMDD, Bg. 2, Rm. 109.

9/3-Dr. Susu.mu Sato, Japan, A pp lied Neurologic Research Branch. Sponsor: Dr. J. Kiflin Pen-

THE NIH RECORD

A double celebration-birthday and farewell-was recently given for Larry Northcutt (I) who retired from NIH after 37 years in the Gove rnment. Mr. Northcutt hos headed the Plant En­gineering Branch's Maintenance Unit in the Clinical Cente r since 19S2-the year the CC was completed. He has been with that Branch since 1948. Ross Holliday, Director, Divi­sion of Engineering Services, wos among the colleagues and co-workers who attended the party.

ry, NINDS, Bg. 36, Rm. 5D08. 9/3 - Dr. Machiko Sakuragawa,

Japan, Laboratory of Vision Re­search. Sponsor: Dr. Toichiro Ku­wahara, NEI, Bg. 6, Rm. 211.

9/ 3--Dr. Andre Van Steirteghen, Belgium, Clinical Pathology De­partment. Sponsor: Dr. Donald S. Young, OC, Bg. 10, Rm. 4N309.

9/ 4-Dr. Noritoshi Takeichi, Ja­pan, Viva! Biology Branch. Spon­sor: Dr. Charles W. Boone, NCI, Bg. 37, Rm. 1C08.

Other Scientists Listed 9/ 4- Dr. Vincent Zigas, Austral­

ia, Laboratory of Central Nervous System Studies. Sponsor: Dr. D. Carlton Gajdusek, NINOS, Bg. 36, Rm. 5B16.

9/ 6 - Dr. Jose J. Bubis, Israel, Laboratory of Neuropathology and Neuroanatomical Sciences. Spon­sor: Dr. Igor Klatzo, NINDS, Bg. 36, Rm. 4D02.

9/ 8 - Dr. Michele Van Eerde­wegh, Belgium, Adult Psychiatry Branch. Sponsor: Dr. William E . Bunney, NIMH, Bg. 10, Rm. 3N212.

9/ 9-Dr. J ean Guegan, France, Virnl Leukemia and Lymphoma Branch. Sponsor: Dr. Dharam V. Ablashi, NOI, Frederick Cancer Research Center, Ft. Detrick.

9/ 9 - Dr. Margarita Zeichner, Mexico, Laboratory of Develop­mental Biology and Anomalies. Sponsor: Dr. George R. Martin, NIDR, Bg. 30, Rm. 412.

Zero Population Growth Defined

Zero Popu!.ation Growth is reach­ed when a population neither in­creases nor declines over a period of time-that is, when the number of births and immigrants is bal­anced by the number of deartihs and immigrants.

THE NIH RECORD

Ethnic Minority Colleges Receive DRR Awards For Biomedical Research

The Division of Research Re­.soul"ces has 0.waroed 15 new grants t-0 ethnic minority colleg·es for bio­medical rescar-ch. These granl;s, totaling $1.8 million, were made under DRR's Minority Biomedical SLipp;,rt Program.

The l\IBS program now funds 66 minority institutions. Grant.les in­clude 51 Black schools, nine Span­i,h-speaking, two native American Indian, two Hawaiian/Polynesian, one insULuLhm with a Black and Spanish-speaking enrollment, and one with a Black and American Indian enrollment.

Assists American Indians

Tunic Mountain Counseling and Rehabilitation Center. the first grantee on an Ameiiean Indian reservation, was among the lfi nBW institutions to reooivc M.8;:,\ funds. The Center, in Bckourt, K.D., is on one of the most de.nsely popu­lated Indian rcservu,tio ns in the Uniter! States.

Researd,ers a~ the Ct>nter an<l Turtle )fountain Community Col­lege are investigating alco.holic problems of the Plains-Ojibway Indians on the reservation.

These stu<lies, which focus on the primary social. ps,rcholo·gical, cultural, and medical fatltors a·sso­ciutcd wiLh alcoholism. will alllo serve as a natiunal pilot pro.gram to sugge.st preventive alcoholism techniques to other Indian tribes.

Science Seminar Scheduled The '.\fRS awtml to Benedict Col­

lege in (',olumbia, S.,C., will provide for a biomedical science seminar to bring research ~cholars to the predominantly Black campus f o r IPe,t.urns and .m~c~ingB with th<c. stu­dent trainees.

Northeastern Sta.te .Cone.g,e, in the capital of the C nerokee nation at Tflhle<iuah, Okla., is another re­cipient of a J\1BS grant. The cur­rent student enrollment indudes 569 American Indian and 436 Black s,tudcnts.

'Open Season' Will Permit Changes in Health ~nefits

T fo e Federal Employees Health Benefits Program is holdin~ an "Open Sea:;on" from :-lov. 15 throug-h Nov. 30.

During t'his period e-ligil:,le employees may enroll.

Also, employees who are en­rolled may change their plan or <>pli,m or converl from self on!:,· to self an<l family or any combination of these changes.

Information on registration pro~urcs, new contract cov­erage, and effective dates will appear in the Nov. 6 is:sue of f.he °!'ilJl Record.

October 8, 1974 Pngc 5

Larry Speiser, SHER's Legal Counsel, to Speak At Meeting on Oct. 16

SHER, the Self Help fo.r Equal Rights Committee, h!llS invited Lan-y S Jleiser to gpeak at its week­ly mEeting· on ¥..' ednesday, Oct. 16, noon to 1 p.m., in Bldg-. 10, Dining Rnom 1.

~ir. Spei8er, :e,ral counsel for u cla&s-action suit on behalf of women of NIH, wili .tnswer ques­tions about what can ·be expHd.Hd if the juJ,gment is favo.rable.

To rais~ funds for legal fees, a rummage sale i.s being held Oct. 19-20 ~t the Pavillion. Gaithers­burg Civii Center. Call Dr. E.A.B. Brnwu, Ext. 6,i193, for udditional informa~ion.

It was announced at a recent SHER meeting that Rosalind .Mur­i,nu,1l had been appointed by Ray­mond J. J~kson, NIH. EEO oJficer, to .head a task force to "develop a methodology for setting numeri­~al g()als a'ld time tablc-s for im­proving equal employment, oppor­tunities of women and minorities at NIH."

1'he financial assistance will al­low' students in the )fortheastern Okluhomu lndian Health Careers Program to enter biomedical re­selclr~h ciu·eer-s an<l als,o offer simi­lar opportu11ities f o r B-lack stu­dents.

Ot.her school~ nw~iving new MBS grnnts include Talladega College fn Alabama; Bcthun;,-Cookman Colleg·c in Da;vtona Beach; Uniwr­,;ity of Hawaii in Hono,lulu; Ken­LuekJ,, S'Lalc Universitj' in Frank­fort; University .of l\laryland in Pi-in~c~s Anne; University of Puerto Ri~o in ).ofayaguez, and the College of the Virgin ls.lands.

MBS Participants Described

T:~e YIBS program now includes 4'.lti faculty members, 895 under­gra,luates, and 147 gra.d".1ate stu­dcn ts. The und0rgraduat-cs incl udc 650 Blacks, 186 Spanish-spe-.iking students, 27 American Indians, and 22 Hawaiian/Po]ync::iian students. Then> ar2 118 Black, 2-~ Spanish­speaking, 1 America~ Indian, and a Huwuiian/Polyntsiun graduate students now particip11ting in the prog;ram.

DRUG INJECTION

dos11g~ of two unit~ of synthetic ca!eitonin p er kilog-ram of body wci•gli.i. inj<,ct,.,d 3 times a week will continue until e a ch pati,mt reach,s puberty, when the bones seem ~o strengthen, possibly be­cause of the incre11,scd supply of sex hormones in the body.

Although this hereditary disease may re.turn in later life, the cen­ter's researchers hope that eai-ly Uwrnpy may prevent crippling de­formities in adulthood.

New Evidence May Explain How Genes 1T urn on' and 'Turn off' in Living Cells

histones

\;••0•7•1:; ' ' By Jane Collins

New evidence that may explain how genes "turn on" and "turn off" in living cells has been d~scr-ibed by Dr. Robert T. Simpson, chief of the Section on Developmental Biochemistry, Lnborutory of Nutrition and Endocrinology, National Institute of Arthri-tis, Metabolis.m, and Di­gcsti ve Ois.eases.

Dr, Simpwn'E finding·s suggcEt that gene~ (comp,rned primarily of the hereditary chemical DNA) are a~tively turned on and able to op­erate when hist.one (protein) bonds attached to the D.t-A o.re loosened.

By contrast, when histoncs are til':htl)' attached to th.a genetic ma­t?~'al, the D)fA ~com;,s folded or "supcrcoiled" and virtuully paraly­zed, and :l is unable Lo generate the '.ife functicms of which it is capable.

Scientists have known for some years lhat each living cell contains hundreds, often thousands of gun es that urc, most of foe time, biologi­( al do-nothings.

::lome genes may turn on only 0'1~e i:i Lh~ lil"etimc of a cell or organism, providing· the critical b:ucprint need-ed for a specific el,Plllil'.al prntluct, thHn rnsunw ""m­p!ete inaetivity.

Sinee all l'fe pro~c,:;seb arc con­trolled by gene activity and reg·u­la1.ion, an undcrs:.anding 0£ gene mechanisms is a major s·cientifk priority.

For his studies, Dr. Simpson em­p'oycd chromfltin, or D)f A linked to hi~tonc pro.tein, as well as pro­tein-free DNA.

Both the chromatin-DNA and the protein-free D1'A were chem­ic.ally exlrnci.Pd by Dr. Sim1,son from cells of the thymus glands of calves.

Evider.ce of whether or not the DNA's were gcn-ctic11lly active, ()r turned on, was pro,ided by their abi!ity to produce a sister chemical, R:\'A, after adding a "priming" Pm<yme.

Dr. Simpson found that, con-

trnsted with the protein-free DNA, folded chromatin-D)fA had only one-tenth to one-twentieth the numb2r of sites for the enzyme to act, limiting its ability to be gen­elirnllv mt.ivH.

He ·then separated the chroma­tin-D)f A into two fraction1:1, one h"'ieved to contain the. genetically turned on DNA, the other, the tllrned off portion.

RJ' utilizing a combination of two separation techniques, Dr. Simpson was able t.o iwlate chrom­atin samples containing ns few as 2 percent and as many as 47 per-0ent of the number of active gene sitcE found on protein-free DNA.

Hy fllrther studying these chrom­atin-D)fA samples with markedly differing genetic activity, he hopes to learn more about tne regulation of gene activity.

The research findings i.11pear in the• latl•st (July) isrne of Proceed­ingR ~! tho NMimwl .-!ct1efc11111 of s,,·ien"e,~ ancl lhe n•,•,•IJl.l." 1>11l1l!sl1ed (}HrrNtl 'l'opic,, in 1/im:ke,a.i.ilry -1.W,8. Aeademic Prt•H~. edite(l hy Drs. Christian B. Annnsen and Alan N. Sehechter, both in :N"IAMDD's La•b­oratory of Chemical Biology.

Patient Care Monogrc1ph Issued

Tl,e Clinical Ce11tn lrn.~ i8~11ed a mnnog:mph f'lliillell .4. NHW IJI­Jf NN<'l!O"/\' IN THE G.J.RH OP JIOf..'PlLif, !'A 'l'rf,'N'l'i:i U,VDER :, 1' 1/RE;S.

This publication reports the re­sults of a multidis-ciplinary study of 16 patients conducted by the :-.Tursi11g Department.

F<1r c.or,ies of the monograph, write to: CC Nur-sing Department, Bl,lg. 10, R.onm 1S-22!'i, NIH, Beth­esda, :\ld. 20014.

Page 6

Health Departments in 12 States Funded to Test For Cancer of Cervix

The National Cancer l nstitute's Can~er Cont rol program has awarded almost $10 million to 12 state health departments for a 3-~·ear program to screen low-income women ior cancer of the uterine cervix.

The health departments will make 1,194,000 screenings during the 3 years. About 306,800 screen­ings will be made the fir st year.

.tward; 1-Year Contracts

Eight additional state health de­partments have one-year NCI con­tracts, totaling $240,303, to plan cervical cancer screening programs. The health departments of all states and U.S. ter ritories may ap­ply for NCI funding to plan or im­plement cervical cancer screening progi·ams.

This year, about 59,500 Ameri­can women will develop cancer of the cervix, the narrow lower por­tion of t he uterus, or womb. An estimated 7,800 women will die from the disease.

"If this cancer is detected at an early stage, the likelihood of pa­tient survival is greatly improved," said Dr . Diane J. Fink, associate director fo1· Cancer Control.

A simple Pap test can detect cervical cancer while the disease is still localized. The test results may also indicate need for additional tests for more advanced forms of cervical cancer.

Test Resulls Tald Women participating in t h e

screening programs will be advised if their Pap test results are sus­picious or positive for cancer and urged to return for retesting and definitive diagnosis. Biopsy (fur­ther study of bits of tissue from the suspicious area), dilation and t urettage of the uterus, and other diagnostic procedures will be used.

When a definitive diagnosis of cancer is made, the state health de­partments contracting with NCI must see that treatment and con­tinuing care arc available.

State health departments are im­p~ementing this program in various ways. In Mi:higan, materials to re­cruit women for screening are be­ing prepared in Spanish and Eng­lish.

Mobile Units Used Mobile testing units are being

used in Connecticut. The Migrant Health Department is cooperating in Nebraska. In a number of states. the program is being subcontracted to county heal th departments, pri­vate medical foundations, and med­ical schools or hospitals with man­power and facilities.

NCI-funded screening programs are beginning in the following states: Connecticut, Kentucky,

October 8, 1974 THE NIH RECORD

NIDR Awards Contract for Study on Release Of Fluoride in Mouth to Fight Tooth Decay

A project to develop a system of prolonged release of fluoride in tne mouth as a means of fighting tooth decay is being initiated un­der a $57,848 one-year contract by tne National Institute of Dental Resear ~h with Polysciences, Inc., ot Warrington, Pa.

Recent studies done at NIDR with animals shows that the great­l s t protection against decay comes from frequent exposure to low lev­els of fluoride dissolved in the mouth rather than from the incor­poration of high levels of fluoride into the teeth.

Different n,ethods of releasing fluoride will be studied over a 12-mon th period. Scientists will try to find a biologically suitable system which will supply fluoride in the mouth at a constant, predetermin­ed rate for a period of at least 6 months without maintenance or adjustment .

The specific methods to be ex-

TASK FORCE (Cu>ttiiwe<l /ran, Page 1)

years and older, will be ooreened annuaJy with a physical examina­tion, X-rays (film mammography or xeroradiography) and thermo­grapily.

~arly detection of breast cancer through a physical examination plus X-ray mammography has been shown to decrease breast can­cer rates.

In the Task Force Report, Dr. Bernard Fisher, University of Pittsbm,gh, and chairman of the Natio,na!' Surgical Adjuvant Breast Project, who spoke in the after­noon session on Primary Therapy of Breast Cancer-A Report, de­scribed a study compai·ing radical mastectomy, total mastectomy (re­moval of breast only) and total mastectomy plus radiation therapy to the chest.

It was shown that the effective­n~ss of each treatment is essen­t:ally equivalent. Further clinical studies involving less surgery (segmental mastectomy~nly part of the br•cast is removed) in breast eancer therapy arc planned.

Also. during the afternoon ses­sion, NCI's Dr. Pa ul Ca11bone talk­ed on Combination Chemotherapy Approa::hes to Breast Cancer. He reported that the results of several studies of patients with metastatic

Louisiana, Michigan, Mississippi, and Nebraska.

Also, New York, Ohio, Okla­homa, South Carolina, Tennessee, and Texas.

One-year planning contracts have been awarded by NCI to the health departments of the follow­ing states: Arizona, California, Missouri, Nevada, Maine, Minne­sota, Washington, and Wyoming.

plored include in corpora ting a safe 1,uoride salt into a mat1·ix of some solt, rubbery, plastic polymer; cov­ering such a salt with a plastic membrane that permits it to dis­solve only at a constant, slow rate; developing a flt)urophosphate com­pound that will break down in the moistu1·e of the mouth and release fluoride gradually, or covering such a compound wi th a membrane to insure slow release.

Also, the scientists will try add­ing fluoride to a gel and contain­ing the mixtu1·c with a plastic membrane to control dispersal.

The contract calls for the estab­lishment of the most promising S_\'S:lt>IJI OI' S.\':4t•U1S iH 1·i1;0, uSing a suitable animal model system for at least 30 days.

The investigations will attempt to determine if a sys-tem of re­leasing fluoride over a period of 6 months is feasible for human use.

disease show that combinations of drugs are more effective than sin­gle drugs.

Researchers at the Mayo Clinic, Albany :Medical College of Union University, and Roswell Park Me­morial Instibu,te reported similar improved results with the combin­ation chemotherapy of cytoxan, fluorouracil and prednisone as compared to using singly two other drugs- adrenalectomy 01· adriamy­cin.

Developing therapeutic programs using effective local treatll)ent combined with safe anticancer drug combinations is an objective of the Breast Cancer Task Force.

NCI's Task Force is also spon­soring studies combining endocrine therapy with chemotherapy. The hormone-drug approach is being studied at the Mayo Clinic and the

Fred Ederer, actin9 chief of NEl's Office of Biometry a nd Epide miala­gy, was recent ly elected a Fe llow of the American Statistical Association; he has been a membe r for a lmost 22 yea rs. Out a t 10,SOO members in the ar9anization, 665 are Fellows. Mr. Ederer, who also heads OBE's Section on Clinical Trials and Natura l History Studies, was honored for "outstand­ing contribut ions in promoting the application of ri9arous statistical methods in clinical tria ls and in the disseminat ion of statistica l acumen to medical invest igators."

Eastern Cooperative Oncology Group.

A summary of the 2-yea.r Breast Cancer Task Force Report "indi­cates that Jess than radical sur­gery is acceptable for the treat­' cnt of primary breast cancer."

The summary ended with the en­couraging note that "the advances in the treatment of early and ad­vanced breast cance1·, coupled with progress in earlier deteotion and diagnosis, should lead to signifi­cant improvements in cure rates and sur vival."

The report did not include re­sults from other studies conducted by NCI and other groups.

Dr. Fisher directed a clinical study involving surgeons, radiotheropists, and pathologists at 3 4 institutions to determine the aptimal treatme nt far primary breast cancer. One thousand seven hundred patients took port in the study.

THE NIH RECORD

Charles Goldstein Heads NLM Lister Hill Center Computer Technology Br.

Charles M. Goldstein bas been appointed chief of the Computer Technology Branch, Lister Hill Center. The Center is a component of the National Library of Medi­cine. The branch is responsible for developing computer-based infor­mation systems for health science applications.

Before coming to NLM, Mr. Goldstein w as with Informatics, where he was technical director for Data Management Systems.

Served With NASA

Prior to that position he served with NASA's Lewis Research Cen­ter in Cleveland where his work included plasma physics and gase­ous electronics research. His last position there was chief of the Scientific Computing Branch.

Mr. Goldstein earned a B.S. in aeroengineering and an M.S. in mechanical engineering, both from Purdue University. Under a Ful­bright Scholarship, he studied mathematics and physics in Ger­many for 2 year,s.

Mr. Goldstein has been involved in problems relating to the impact o:'.' computer technology on both in­formation transfer a n d adminis­trative management. He is the author of numerous scientific pa­pers on these subjects.

NEI Vision Research Lab Holds Seminar Series

Because of increasing interest in the role of the pigment epitheli­um in eye disorders, the National Eye Institute's Laboratory of Vi­sion Research recently initiated a series of six informal seminars en­ti tied Renaissance of the Retinal Pigment Epithelium.

The luncheon meetings were held in late September and eady October.

Within t he past few years re­searchers have directed major at­tention to a single cell layer of the retina called the pigment epitheli­um. This narrow band lies between the sensory portion of the retina (the light-sensitive tissue at the back of the eye) and the underly­ing blood vessel-rich tissue, the choroid.

New Techniques Used

The NE! scientists pointed out that, until recently, studies of reti­nal degenerative conditions were directed primarily toward the neur­al portion of the ret ina. However, as a result of new research tech­niques, investigators have discov­ered that the pigment epithelium plays a vital role in the visual process.

Efforts a·re now being made to elucidate the key part played by this narrow layer in normal reti­nal function and in the develop­ment of cer tain retinal diseases.

October 8, 1974

Early Diagnosis of Multiple Myeloma Now Possible With Improved Technique

,.

Ors. Graham and Be rnier discuss symptoms with a patient suffering from multiple mye lomo at the General Clinical Research Center (University Hospi­tals af Cleve land), which is supported by the Division of Research Resources.

An improved method for ear ly diagnosis of multiple myeloma,a malig­nan.t tumor of the bone marrow plasma cells, has been developed by two physicians at the University Hospitals of Cleveland.

Using electron microscopic techniques, Dr. George M. Bernier, director of medical oncology, and Dr. Rich­ard C. Graham, Jr., head of the Division of Infectious Disease, have developed a method that allows physicians to differentiate more accurately between a non-malig­nant tumor of plasma cells and a malignant tumor.

Analysis of bone marrow cells from 65 patients was involved in the study, which was supported in part by the Division of Research Resources,

Affects the Middle-Aged

Multiple myeloma, which affects people nearing 50 and over, is basically a tumor of an antibody­producing cell- th e plasma cell. The pat ient complains of neuralgic pains; later, painful swellings ap­pear on t he ribs and skull, and spontaneous fractures may occur,

In the past, there has been no agreement among specialists that the plasma cells which proliferate in multiple myeloma are recogniz­ably abnormal.

Studying large numbers of pa­tients at the hospital's ORR-sup­ported General Clinical Research Center, Drs. Bernier and Graham found that not only is there a rec­ognizable abnormality in cells in multiple myeloma, but that the de­gree of abno-rmality also closely parallels the clinical severity of the disease.

A plasma cell consists of two parts, the nucleus and the cyto­plasm, which normally mature at the same rate.

The t w o biomedical scientists discovered that in multiple myclo-

ma there is a lack of synchroniza­tion between the two parts of the plasma cell. The nucleus of the multiple plasma cell tends to re­main immat ure, whereas the cyto­plasm develops to maturity,

Researche rs Hopefu I The investigators are hopeful

that their findings will permit de­finitive treatment to be started in some patients earlier th an was previously possible.

Currently, Ors. Bernier and Gra­ham arc examining the changes which come about throug,h ,treat­ment, and hope to determine whether they can predict respon­siveness to treatment.

Their findings were recently pre­sented at the annual meeting of t he American Society of Hema­to!ogy,

Dr. Frederick L. Stone Joins

B.iston University M ed. Center

Dr. Frederick L. Stone, former Director of the National Institute of General Medical Sciences and­more recently--0eputy director of the Health Services Administra­tion, HEW, is now deputy director of the Boston University Medical Center.

In addition to working with Dr. Richard H. Egdahl, BUMC Direc­tor, in directing the Medical Cen­ter's financial and operational ac­tivities and program development, Dr. Stone will serve as the Univer­sit y's associate vice president for health a ffairs.

Page 7

Dr, Delappe Is Chief Of Parasitology Branch, NIAID Extramural Area

Dr. Irving P. Delappe has been appointed Cflief 01 the Parasitolo­gy a n d JVledical Entomology <>ranc,1 in the National Institute t-, Allergy and I ntectious Diseases' Extramural Pr,ograms.

He succeeds Dr. Wilford S. Bail­ey, who has returned to Auburn Universi ty as professor of path­ology and parasitology.

In addition to administering NIAID's r esea1·ch grant and train­ing program in parasitology, Dr. Delappe will be planning and di­recting two special emphasis pro­gram areas. One, the biological regulation of vectors is concerned with investigations on the control of arthropods that transmit dis­ease.

Program Explained

The other program focuses on studies in immunity to animal par­asites with the view to eventual development of vaccines for t b e prevention of parasitic diseases.

Dr. Delappe will a Is o remain chief of the Biochemistry and Physiology Branch where he has served since his appointment in 1965. He will continue to coordin­ate a special emphasis grants pro­gram on the mechanisms of resist­ance to antimicrobial agents.

As chief of this branch, Dr. De­lappe has made a significant contri­bution through his promotion of basic research on antiviral sub­stances.

Information on the underlying regulation mechanisms responsible for viral replication is of particu­lar interest since one of the pro­gram goals of the Branch is the development of antiviral agents tailored to attack replication at vulnerable points.

Dr. Delappe joined NIH in 1960 as a scientist administrator in the Division of Research Grants and moved to NIAID in 1962.

Or. Oe lappe's expe rtise in bacterio­phage research hos he lped NIAIO to define and evaluate its program goals in this area.

Page 8

Symposium and Exhibit On Research Equipment To Open Here Oct. 22

A Sympos ium on Recent Devel­opments in Research Methods and Instrumentation will be held Oct. 22-24 in the Masur Auditorium.

In conjunction with this meet­ing, there will be an exhibit of equipment directly related to sym­i;osium topics in Bldg. 31, Confer­ence Room 5.

Times Given

Symposium sessions will be held from 9:30 a.m. to noon and from 2 to 4 :30 p.m., and the exhibit will be open from 10 a.m. to 5:30 p.m. Both are open to the public.

Dr. J ohn I. Peterson, Division of Research Services, is chairman of the initial session on separation science techniques.

Among topics to be discussed a r e centrifugal countercurrent chromatography, transient electro­phoretic a nalysis of biomolecules and cells, and affinity chrnmatog­raphy, principles and applications.

Other session chairmen include Dr. Harry Pardue, Purdue Univer­sity; Dr. Vincent H. Bono, Jr., Na­tional Cancer Institute; Dr. Ralph Nossa!, Division of Computer Re­s ,\rch and Technology; Dr. Lester Goodman, DRS, and Dr. John H. Buss-er, Alliance for Engineering in Medicine and Biology.

Subsequent symposium sessions will include discussions of modern applications of enzymes as re­agents, electronic cell sorting, laser light source spectroscopy, ultra­sonic diagnostic imaging, and ra-

October 8, 1974

First Contributions to CFC Tabulated; Fogarty Center Surpasses Its Quota

Early contributions to the NIH Combined Federal Campaign have been tabulated for the first reporting period-as of Sept. 27, $10,495 has been donated. This amount was contributed by 228 employees, averaging $46 per ptirson.

The Fogarty International Cen­ter was first to surpass its quota, rcp-ort-ing 129 p ercent, and an aver­age gift of $47.

OD averaged $105, while NIC­HD's average was $65, ,and NINOS and NIAID both averaged $63.

With the theme, "NIH ... Car­ing Comes Naturally," the CFC opened here Sept. 19. On the p-re-

Film Dramatizes Services Of Agencies Helped by CFC

A n e w Combined Federal Campaign film, Th e Long Journey, will be shown in the Masur Auditorium on Wednes­day, Oct. 16, Thursday, Oct. 17, and Friday, Oct. 18, at 11:30 a .m. and 12 noon.

The 15-minute color movie dramatizes health and welfare services offered by organiza­tions benefitting from the CFC.

Starring in the production are actors Dean Jones and Robert Hooks.

diation and radioisotope diagnostic imaging.

The symposium a nd exhibit are being sponsored by NIH and local chapters of seven national scien­ti fie societies.

For f urther information, call Judy Summers, Ext. 62317.

ceding day, Dr. Milo Leavitt, Di­rector of the Fogarty Internation­al Center and CFC vice chairman, addressed the first meeting of NIH coordinators.

"Equalling or s urpassing last year 's NIH goal is no small task. Last year, NIH contributed more money, over $207,000, than any other agency in the Department of Health, Education, and Welfare.

"We topped our goal and finish­ed with UG percent, and an aver­age contribution of aimost $30 per person," he said.

Dr. Leavitt also emphasized that the success of this year's drive depends to a large extent on a)l of the NIH coordinators and key­people.

Dr. Robert S. Stone, NIH Dir,ec­tor and CFC chairman, r eminded the group that the CFC is the only campaign of its kind conducted during the year for Federal em­ployees.

"In a large sense, our chosen daily wo,rk here reflects the con­cept of caring for and about peo­p!e. Our support of basic biomedi­cal research is indicative of the concern that we have for bhe Na­tion's health and well-being," he said.

Holds Troining Session George Presson, F IC executive

offic-er and NIH coordinator for CFC, explained to the gathering that the traditional CF'C "kick-off" rally has been r eplaced t his year with training sessions for small groups which hopdully will be more effective and allow more di­rect, personal communication.

i\1r. Presson asked coordinators to str ess the advantages of the payroll deduction plan to keymen and campaign oontributors.

"This is the easiest, least pain­ful way of giving. The contribu­tion is automatically deducted and doES not start un til ne:i..'t January. The money is not mis.s-ed as much as a Jump sum would be, and the employee's pay slip serves as a tax receipt," he said.

Goal Raised Slightly NIH's goal for this year, $187,-

380, has been raised slightly over last year's, $179,309.

"We a~complished such a fine r acord last year because of the hard work and dedication of our coordinators and keypeople, and the charity of our employees.

"This year , I feel confident that NIH, in the same spirit of giving and caring about our fellow human b; ings, will once again surpass its goal," added Dr. Leavitt.

THE NIH RECORD

Dr. Rosenberg Is Chief Of Surgery Branch, NCI

/ I

Dr. Rosenberg comes to the compus from Pe ter e ent Brighom Hospital. Four years ago--for o 2-yeor period -he served as o clinico I ossociate in NCl's Immunology Branch.

Dr. Steven A. Rosenberg has been named chief of the National Cancer Institute's Surgery Branch. That branch is part of the Divi­sion of Cancer Biology and Diag­nosis.

Dr. Rosenberg comes to NCI from Peter Bent Brigham Hospital in Boston, where he was a resident in surgery during 1968-69 and 1972-74.

From 1970-72, he was a clinical associate in the NCI Lmmunology Branch and before that, a research fellow in immunology at Harvard Medical School.

Degrees From Johns Hopkins, Harvord

Dr. Rosenberg received both his B.A. and M.D. degrees f rom the Johns Hopkins University, and a Ph.D. in biophysics from Harvard University.

His research interests include cancer immunology and organ trnnsplantation. He has been a member of the NCI Tumor Immu­nology Scientific Review Group, and, since 1972, served on the ad­viso,·y board of NCI's International Regist ry of Tumor Immunother­apy.

Dr. Rosenberg is a member of the American Association :for Can­ce,· Research, the American Asso­ciation of Immunologists, and the American Association for the Ad­vancement of Science.

Research Explained Research in the Surgery Branch

includes clinical studies of treat­ment foT patients with cancer of the breast, colon, cervix, head and neck, bone and soft tissue, skin, and urogenital system.

The branch also provides gen­eral surgical services for patients of other Institutes in the Clinical Center.

COMBINED FEDERAL CAMPAIGN literoture, flogs, posters, ond chorts con­not provide o true feeling of whot the drive is obout. Three NIH compoign worke rs recently took o trip to see how the CFC he lps people-in this cose young childre n. Trocie Sheo, Pot Gorman, ond Edna Walker (I to r) visited a branch of the Montgomery County Associotion for Retarded Citixe ns at the Cedor Lane Unitorion Church, which conducts progroms for children and young odults who ore not oble to ottend public schools.- Photos by Tom Joy. * U.S. GOVERNMEN T PRINTING OF'F"ICE: l973-S44•802/ 2.a