first southern african genomes sequenced
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20 February 2010 | NewScientist | 5
The product is actually three skin creams known as Olay Pro-X, designed to alter the expression of genes involved in skin ageing. Women using this for 24 weeks were as likely to see their wrinkles reduced as women on tretinoin, a drug for reducing skin-ageing. The judges were unaware of who had used which product (British
Journal of Dermatology, DOI: 10.1111/j.1365-2133.2009.09436.x).
“I’m hoping that the public will fall for hard data and base their decisions on that,” says Richard Weller , a dermatologist at the University of Edinburgh, UK, who was not involved in the study.
SETI to expand?
FRANK DRAKE , the founder of the Search for Extraterrestrial Intelligence (SETI), wants to take the search for aliens further: about 82 billion kilometres away, in fact .
At this point in space, electromagnetic signals from planets orbiting distant stars would be focused by the gravitational lensing effect of our sun, making them, in theory, more easily detected. Drake wants to send spacecraft there in a bid to overhear alien communications, which would be too faint for telescopes on Earth to detect.
It’s neither a new or original idea, but it has never taken off because of the distances involved . With existing propulsion technologies, spacecraft would take hundreds of years to make the voyage, which is about 550 times the distance from Earth to the sun .
Gravitational lenses could also be used to transmit signals , amplifying them so they could travel further and potentiallyreach distant civilisations. It’s also possible, Drake says, that intelligent civilisations have built an intergalactic internet using such techniques and are just “waiting for us to log on”.
Drake spoke last week at the TED 2010 conference in Long Beach, California .
Own up, hit back
IN A flurry of recent interviews, the scientist at the heart of the “climategate” affair has broken a 12-week silence.
Phil Jones, former director of the University of East Anglia’s Climatic Research Unit in the UK, has spoken about the controversy that followed publication of emails stolen from the CRU. He admitted to the journal Nature that his failure to keep records of the locations of weather stations used in a major study was “not acceptable”. In effect, Jones conceded that climate sceptic
Doug Keenan had been right in some of his criticisms of the paper, which ruled out local urban influences as a significant factor in global warming.
Jones said he may submit a correction to Nature, but
nonetheless hit back at bloggers and other critics for “hijacking the peer-review process. If they want to criticise, they should write their own papers,” he said.
“Jones admits his failure to keep records of weather stations’ locations was ‘not acceptable’ ”
THE genome club just claimed its
first clergyman, in the shape of
Archbishop Desmond Tutu. Tutu
and a Khoisan man from the Kalahari
are the first southern Africans to
have their genomes sequenced
and published.
In November 2008, a Han Chinese
man and a Nigerian man became
the first non-whites to have their
genomes sequenced. Each of the
southern African genomes is a source
of further untapped genetic diversity.
Interestingly, their genomes are as
similar to Europeans’ as they are
to the other sequenced African
genomes – both from Yorubas.
The genome of Tutu, a Bantu,
yielded over 412,000 new variants.
An even greater number came from
the unnamed Khoisan – almost
744,000. This is probably because
Khoisans were among the earliest
human populations to form and
they have not interbred much with
other groups, says project leader
Stephan Schuster , a genomicist at
Pennsylvania State University in
University Park (Nature, DOI:
10.1038/nature08795) .
Schuster’s team say some of the
Khoisan’s mutations may be down to
the group’s largely hunter-gatherer
lifestyle. Meanwhile, variants lurking
in both new genomes may help
explain why some southern Africans
respond poorly to existing anti-
retroviral drugs that treat HIV. If so,
this could help design more effective
anti-retrovirals, says Schuster.
Tutu flies flag for African genomes
–Tutu leads the way–
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Higgs gets massThe search for the Higgs boson got
a boost last week. The D0 and CDF
experiments at Fermilab’s Tevatron
collider in Batavia, Illinois, published
three papers in Physical Review
Letters showing that the “God
particle” must have a mass between
115 and 150 gigaelectronvolts.
Space panoramaThe International Space Station has
had a “penthouse” upgrade. Last
week, shuttle astronauts added
a new module called Tranquility
and a swanky observation dome
called Cupola. The dome has seven
windows and gives astronauts a
panoramic view of Earth and space.
Phantom menaceThe US Missile Defense Agency has
finally shot down a moving missile
with an airborne laser, but military
experts say the system – once known
as “Star Wars” – is not good enough
for combat. That’s because the
system only works if it gets within a
few hundred kilometres of a missile
less than 2 minutes after launch.
King Tut’s mummyThe most comprehensive analysis
yet of DNA from the remains of
Tutankhamen and 10 of his close
relatives has established that two
previously unnamed mummies are
indeed his mother and father, and
two fetuses his daughters. The
analyses suggest that Tutankhamen
probably died aged 19 from a leg
fracture followed by a malaria
infection ( Journal of the American
Medical Association, vol 303, p 638).
Prostate cancer zapMen with incurable prostate cancer
have responded well to a drug
called abiraterone, which shrank
or stabilised tumours for an average
of six months in the 47 subjects.
The best existing treatment
extends life by only two or three
months. Five of the 47 are still
taking the drug three years on and
a much larger trial is now planned.
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