FEBS Letters Volumes 16% 178 Master Subject Index

Volumes 165-178 (1984)

Absolute molecular weight, (175) 419 Absorption change, (173) 9 Absorption maximum, (166) 245 Absorption spectrum, (170) 326 Accurate transcription initiation, (168) 275 Acetyl-CoA, (166) 331; (177) 157 Acetyl-LDL, (171) 149 Acetylaminofluorene, (178) 59 Acetylated N-terminus, (170) 281 Acetylation, (175) 407 Acetylcholine, (168) 143; (175) 165: (176) 457 Acetylcholine receptor, (166) i46; (1‘69) 229; (172) 1; (173) 217;

45

(178) 204 Acetylcholinesterase, (168) 231; (170) 147 3-[‘sF]Acetylcyclofoxy, (177) 281 N-Acetylgalactosamine, (168) 197 N-Acetylglucosamine, (173) 63 a,-Acid glycoprotein, (168) 79 Acid-induced growth, (174) 223 Acid secretion, (177) 227 Aconitase, (178) 245 Acridine, (169) 123 Acridine orange, ( 165) 238; (168) 15 Actin, (167) 155; (169) 161; (170) 94; (170) 259; (173) 399;

(173)403;(174)80;(176)313 Actin binding, (173) 119 Actin-binding site, (176) 75 Actin capping protein, (177) 184 Actin filament, (166) 90; (167) 52 Actin-modulating protein, (177) 209 Actin modulatisr, (166) 90 Actin-myosin interaction, (177) 209 Actin polymerization, (173) 399; (177) 184 F-Actin conformational change, (k76) 441 F-Actin-vinculin interaction, (165) 26 Actinomycin D, (166) 199 Activation-desensitization, (174) 267 Active chromatin, (169) 309 Activesite,(l71)253;(173)58;(174)96 Active transport, (166) 1; (177) 146 Activity staining, (170) 263 Actomyosin, (176) 161 Actomyosin ATPase, (174) 11 Actomyosin ATPase activator, (178) 311 Actomyosin-subfragment one, (174) 11 Acute-phase protein, (177) 89 Acyl-CoA reductase, (169) 35 Acyl-CoA ester, (175) 284 Acyl-CoA hydrolase., (176) 334 Acylenzyme,(l65) 185 Acylation, (172) 326 Adair equation, (168) 27 1 Adenine nucleotide binding, (173) 394 Adenine nucleotide translocator, (177) 231 Adenosine, (170) 365; (175) 68; (178) 132 Adenosine analog, (167) 142; (173) 385; (178) 132 Adenosine deaminase, (175) 68 S-Adenosyl-L-homocysteine hydrolase, (165) 265 Adenosylcobalamin, (171) 73 Adenovirus, (171) 5 Adenylatecyclase,(l65)290;(166) 13;(166)170;(166)273;

(166) 277; (167) 113; (169) 133; (169) 261; (170) 38; (170) 320;

(171)95;(171)233;(172)55;(172)321;(174)50,(177)227 Adenylyl cyclase, (175) 25 Adipocyte,(l67)5;(173)385;(175)68;(177)217 Adipose tissue, (178) 132 ADP binding, (170) 121 ADP-binding site, (178) 10 ADPrelease, (170) 121 ADP-ribose. transferasc, (169) 241 ADP-ribosylation, (171) 233; (172) 91; (176) 261; (176) 301;

(176)406 ADP-ribosyltransferase, (173) 113 ADP stimulation, (173) 164 tightly bound ADP, (170) 121 Adrenal cell, (173) 23 Adrenalectomy, (166) 385 a-Adrenergic agonist, (167) 19 /I-Adrenergic ligand, (169) 15 1 a,-Adrenergic receptor, (166) 385 rqAdrenergic receptor, (170) 387 &Adrenergic receptor, (166) 385; (169) 151 Adrenoceptor, (177) 143 q-Adrenoceptor, (172) 95 Adrenocorticotropic hormone fragment, (173) 23 a-Adrenocorticotropic hormone, (168) 208 &Adrenoreceptor, (178) 240 Adriamycin, (166) 232 Adriamycin-Fd + complex, (176) 97 ADRY reagent, (165) 156 A&my, (170) 239 Affinity chromatography, (167) 277; (169) 156; (169) 215;

(171) 37; (174) 162; (174)279; (177) 195 Affinity column, (168) 203 Affinity labeling, (169) 101; (170) 290 Athnity modification, (172) 43 Affinity partitioning, (174) 162 Agglutination, (174) I32 Agglutinin, (175) 82 Aggregation, (176) 27; (176) 313 Agonist afiinit y. (169) 229 Alanine, (173) 407 Alanine aminotransferase, (171) 59 (S)-Alanine, (17 1) 79 Alarmone, ( 178) 149 Albumin, (168) 208; (173) 173; (174) 162; (176) 27 Alcohol dehydrogenam, (176) 32 1; (178) 249 Alcohol dehydrogenase. isoenxyme, (173) 360 Alcohol-polyol-sugar dehydrogenase, (165) 190 Aldehyde dehydrogenase, ( 168) 2 17 Aldo/keto reductase, (170) 263 Aldosterone, (17 1) 179 Aldosterone secretion, (174) 211 Alkaline phosphatase., (169) 313; (171) 67; (173) 48; (173) 357 Alkaline phosphatase isozyme, (175) 343 Alkalineprotease,(l76)2ll;(l76)2l5 Alkalinixation, (171) 165 Alkenylacyl derivative, (165) 273 Alkoxyphospholipid , (169) 35 Alkylacyl derivative, (165) 273 Alkylating agent, (176) 426 Allele, (168) 103 a-Allenyl putrescine, (174) 275 Allosteric modulation, (167) 199

46 Volumes 165-178 (1984)

Ailosteric regufation, (171) f37 AIloxan, (178) 245 ALTV-transformed cell, (177) 290 Aluminium-binding constant, (176) 129 Aluminium-iron competition, (176) 129 Alveolar macro&age, (174) 61 Amiloride, (172) 272 Amine ox&se, (I 70) 305; (176) 378 Ammo acid analysis, (f65) 45; (f69) I99 Amino acid composition, (174) 20 Amino acid composition, (174) 24 Ammo acid content, (175) 443 Amino acid residue, (166) 19 Aminoacid sequence, (165) 6; (165) 11; (166) 19; (166) 33;

(166) 39; (166) 339; ($66) 367; (167) 98; (167) 210; (167) 215; (167)22f;f167}MI;(l67)309;~168)227;fiCls)293;(f59)~; (169) 143;(I70) 105;(1?0)259;(170)281;(171)293;f172) f; (172)80;(172)209,(173)367;(173)394;(174)112;(174)151; (174)289;(175)76;(175)208;(175)213;(175)333;(175)349; (175)359;(176)37;(176)176;(176)239;(177)260;(178)97; (178) 213;(178) 233

Amino acid sequence analysis, (168) 29 Amino-acid sequencing, (175) 2 I Amino acid transport, (171) 227; (177) 249 a-Amino acid regulation, (I 71) 137 9-Aminoacridine,(l67) 181;(167)231;(172)275 Aminoacyl-tRNA synthetase, (178) 6 y-Aminobutyricacid,(l71)303;(175) 193;{177)249 ~-Amin~s-~aprol~tam racemase Amine racemase, (174) 76 I -~~j~~~~l~~~n~~ -carbtrxylic acid, (167) 64; (172) 47 I -Aminocyclopropane 1 -carboxylic acid, ( f 73) 139 s-(B-Aminoethyl)-Lslysteine-&-la~tam, (174) 76 Aminofluorene, (I 78) 59 k4minolevulinate synthase, (166) 298 6-Amino-2-naphthyl-4guanidinobenzoate, (172) 159 Amjno~ptid~~, (166) 183; (175) 124; (175) 135 Am~no~ptidase N, (171) 227 L-a-Amino_8-thio-E-caprola~t~, (f 74) 76 Ammonia,(l66)331 Ammonium repression, (176) 453 AMP, (167) 1% (170) 223 AMP effect, (167) 203 cyclic AMP, (165) 265; (166) 96; (166) 16% (166) 189; (166) 199;

fl6s)283;(~6?~~13;f167)343;[168)317;(158)323; (170)2?3~~170~3~~~71~ lOl;(t72} lQ(t74) 13z;(l75)72; (1?6)49;(176)220;{I76}235;(177)17;(177)143;(178)83; (178) 132; (178) 143

cyclic AMP dependence, (167) 203; (169) 224; (171) 211; (176)65;(178)73

cyclic AMP independence, ( 170) 33 cyclic AMP pbosphodj~t~r~, (167) 25 cychc AMP production, (169) 21 cyclic AMP receptor, (176) 245 cyclic AMP receptor protein-specific site, (165) 216; (175) 117 8-bromo cyclic AMP, (168) 222 Amphipathic protein structure, (175) 263 Amphotezicin B, { f 78) I27 Amyhtse secretion, ($70) WT (172) 284 u-Amy&e, (167) 210 cr-Amytase inhibitor, (It%‘) 221 Anaerobic respiration, (170) 320; (171) 309 Anchor peptide, (168) 231

Andro~n~~ndent protease, (175) 1 Androgenie repression, ff7D) 114 IdAndrostene, (167) 103; (174) 173 Angiotensin-converting enzyme, (166) 183; (173) 307 Angiotensin-converting enzyme inhibitor, (165) 201 Angi&nsinII,(170)243;(171)179 Angiotensin II heptapeptide, (170) 243 2,5-Anhydro-f3_rnannitoi~ (165) 247 Anion conductance, (179) 186 Anion effect, (178) 249 Anion transport, (169) 234 Anionic form, (170) 229 BlOZOAntennacbmplex,(171)267 B80&850 Antenna pigment complex, (177) 61 Anterior pit~ta~, (178) 319 Antbmcene, (174) 1 A~~aqu~none triazine dye, (I 78) 288 Anti-peptide antibody, (178) 204 Antibiotic, (173) 134 Antibody,(165)83;(178) 153 Antibody additivity assay, (174) 294 Antibody binding, (176) 43 Antibody production, (17f) 4t ~ti8e~,(l~4~? Antigen-antibody complex, (177) $95 Antigenic determinant, (168) 302 Antigenic receptor, (168) 143 Antigenicsite, (175) 333; (178) 204 Antigenicity, (178) 291 Antj~~~sive~ (XS) 201 Antimycin, (178) 343 Antimycin-sensitivity, (178) 336 Antioxidant-sensitive respiration, (178) i 19 Antiserum, (165) 211; (171) 262 Antithrombin. (171) 157 Ant~th~id drug, (176) 337 +Antitrypsin, (166) 67; (177) I79 q-Antitrypsin secretion, (t&3) 84 a,~Antitrypsin variant, (168) 84 Antitumor antibiotic, (167) 37 Antitumor platinum, (176) 389 AP site, (178) 223 3’ AP endonuckase, (178) 223 Apocytoehrome b gene, (169) 73 A~ii~rotein, (175) 263 Apohpoprotein A-II, (I 75) 159 Apohpoprotein B, (170) 105 Aqueous two-phase partition, (172) 109 Ara&idonicacid,(l65)273;(172)279;(173)414;(176)93;

(176) 202; (178) 319 A~haeba~te~a, (172) 289; (176) 176; (177) 189 Ar~ine-~i~~ reagent, (169) 234 Ascorbate, (I 78) 25 Asparaginase,(l71)67 Aspartate, (177) 249 Aspartate aminotransfernse, ( 170) 223; ( 17 1) 59 Aspartate kinase, (175) 238 ~p~te~~u~~te carrier, (176) 351 LAspartate, (177) 157 Asps& proteinase, (174) 96 Assembly factor, (175) 32 1 Assignment, (176) 307

Volumes 165-178 (1984)

Assignment strategy, (173) 342 Assimilatory sulfate reduction, (170) 76 Asthma, (168) 23 ATP,(l66)331;(167)259;(171) 137;(176) 161 ATP analog, (175) 303 ATP-binding site, (175) 387 ATP-dependent protease, (166) 248 ATP hydrolysis, (175) 433 ATP-induced assembly, (178) 264 ATP production, (168) 321 ATP stimulation, (166) 253 ATP synthase, (177) 274 ATP synthesis, (167) 83; (175) 95 ATP synthetase, (167) 176 cytosolic ATP level, (165) 145 F,F,-ATP synthase, (178) 10 ATPadenylylsulfate 3’-phosphotransferase, (170) 76 ATPase, (168) 7; (168) 15; (168) 260; (170) 94; (171) 169;

(171) 262; (178) 209 ATPase activity, (177) 85 ATPaseinhibitor, (170) 135; (174) 151 ATPase regulation, (166) 85 ATPase subunit, (175) 109 bacterial F,-ATPase, (174) 66 CaZ+-ATPase, (167) 33; (177) 146 (Ca* + + MgZ+)-ATPase, (172) 250 F,-ATPase, (167) 285; (169) 101; (171) 249; (178) 161 F,,F,-ATPase, (175) 109 F,F,-ATPase, (170) 135 H+-ATPase,(l67)231;(172)209 (K+ +M$+)-ATPase,(l71) 271 Mg2+-ATPase, (175) 422 (Naf + K+)-ATPase, (172) 114; (173) 196; (175) 275; (175) 303;

(176) 223 Solubilized ATPase, (174) 233 endogenous (Na+ + K+)-ATPase inhibitor, (176) 223 natural ATPase inhibitor, (177) 85 Atria1 natriuretic factor, (167) 352 Autocatalytic phosphorylation, (177) 112 Autophosphorylation, (166) 335 Auxin-induced elongation, (177) 1 Axonal transport, (165) 128 AzidoP4C]atrazine, (167) 327 PHlAzidopine, (169) 112

47

~-cell replication, (177) 135 /Ivariant, (172) 155; (178) 315 B-Z transition enthalpy, (173) 243 Bacteria toxin, (173) 113 Bacterial cell wall, (173) 185 Bacterial chromatin, (170) 99 Bacterial cytochrome c-oxidase, (170) 301 Bacterial electron transport, (171) 309 Bacterial expression, (166) 67 Bacterial flagellar motor, (176) 287 Bacterial haloperoxidase, (173) 5 Bacterial photosynthesis, (168) 149; (177) 277 Bacterial protein kinase, (173) 337 Bacterial reaction center, (167) 327 Bacteriochlorophyll b, (171) 267 Bacteriochlorophyll change, (I 78) 301 Bacteriophage 1, (165) 238

Bacteriophage 8x174, (173) 351 Bacteriorhodopsin, (178) 33 1 Bacteroid, (168) 321 Band 3, (169) 234 Barbiturate, (175) 193 Base pair, (171) 325 Base type assignment, (175) 259 Basement membrane, (173) 75 Basic protein, (177) 236 Basidiomycete, (169) 247 PHI-BAY K 8644, (167) 88 /S-Bend, (174) 310 Benzodiazepine, ( 169) 138 Benzodiazepine receptor, (173) 255; (176) 69 Be&tin, (175) 124 Bezafibrate,(l71) 187 Bicarbonate effect, (175) 243 Bifunctional inhibitor, (167) 210 Bilayer curvature, (168) 43 Bilayer permeability, (17 1) 160 Bile acid binder, (177) 3 1 Bile acid synthesis, (168) 3 17 Bile salt-stimulated lipase, (170) 375 Binding alhnity, (178) 10 Bindingassay,(l70) 15;(175)299 Binding domain, (175) 90 Binding enthalpy, (175) 249 Binding globulin, (168) 307 Binding protein, (169) 283 Binding region, (168) 227 Binding study, (170) 243 Bioactive processing, (175) 407 Bioenergetics, (176) 287 Biogenesis, (166) 28 Biological modification, (17 1) 149 Biomechanics, (176) 287 Biosynthesis, (168) 293; (172) 309; (175) 199 Biotin-avidin interaction, (176) 75 Birefringence, (173) 403 Bis-intercalation, (176) 4 14 Bis(2-ethylhexyl)sulfosuccinate reverse micelle, (178) 39 Blocking antibody, (173) 357 Bloodcoagulation, (165) 102; (168) 287; (173) 169 Blood glucose, (176) 16 B1oodgroup,(167)47;(170)254;(172)99;(174)55 Blood group H antigen, (175) 397 Bluecopper, (171) 257 Body fluid, (168) 235 Bombesin, (166) 277; (166) 283 Branched chain, (172) 38 Branched-chain keto acid dehydrogenase, (168) 265 Bromination, (173) 5 I-Bromoguanine, (168) 302 Briinsted equation, (173) 179 Brown adipocyte, (170) 18 1 Brown adipose tissue, (166) 141; (166) 151; (166) 393; (167) 10;

(170) 186; (176) 16; (178)240 Brush border enzyme, (172) 25 Brushbordermembrane,(l71)227;(174)30 Brush border protease, (169) 53 Buffering power, (171) 165 Bufuralol-l’-hydroxylation, (173) 287

48

Butanol treatment, (175) 429 t-Butyl hydroperoxide, (168) 38 Butylated hydroxytoluene, (165) 277

C-terminal amide, (174) 258; (174) 289 Cl r activation, (172) 159 Clr active site determination, (172) 159 Clr intermediant, (172) 159 Cls,(165) 111 C2, (165) 111 C4, (165) 111 C4d, (170) 254 cII/cIII, (177) 1 f5

(170)49;(170)169;(171)95;(173)80;(173)414;(174)50; (174)90;(175) 170;(176) 139;(176) 144;(176) 151;(176) 193; (176)317;(176)457;(177)36;(177)76;(177)95

cytosolicC3+,(167) 19;(168)38;(170)196;(175)72 cytosolicfreeCa*+,(166)44,(177) 17 freeCa*+,(169) 189 intracellularCa2+,(171)315;(174)71 Ca2+ activation,(l66) 115;(168)260;(171) 173 Ca* + ATPase, (177) 146 CaZ+-binding protein, (178) 157 Ca*+-bindingsite,(167)33;(171)89 Ca*+ channel, (169) 112; (176) 371 Ca* ‘-channel activation, (167) 88 Caz + dependence, (166) 90 Caz+ effect, (166) 258 C$ + efflux, (166) 283 Caz+ influx, (167) 19 Ca* + ionophore, (175) 147 Caz+ mobilization, (168) 54; (176) 411 Caz+ pool, (167) 241 CaZ’pump,(166) 1;(172)250 Ca2 ’ release, ( 167) 123 Ca2 + sequestration, (174) 7 1 Caz +-specific restoration, (168) 28 1 Caz+ substitution, (168) 118 Caz+ transport, (171) 89; (174) 30 Caz +calmodulin, (169) 127 Caz+/C1-effect,(175)31 CaCI, treatment, (176) 341; (176) 346 CaCI, washing, (168) 28 1 Cadmium, (168) 61 Caffeine, (167) 123; (170) 365 Calcineurin, (165) 269; (169) 25 1 Calcitonin, (174) 86 Calmodulin,(166)373;(167)215;(167)332;(170)49;(170)383;

(172) 109;(172)315;(174)30;(174)50;(175)238;(176)235; (176) 317; (177)95; (178) 157

Calmoduhn antagonist, (174) 30 Calmodulin inhibitor, (178) 44 Calorimetry, (171) 145 Calpain, (170) 259 Cancer therapy, (172) 17 CAPP-calmodulin, (165) 269 Capped RNA fragment, (166) 57 5’-Capped (2’-5’)-adenylate, (166) 57 5’-Capped (3’-5’)-adenylate, (166) 57 Capping, (169) 161 Carbacyclin, (165) 290

Volumes 16>178 (1984)

Carbamoyl phosphate, (165) 197; (167) 259 Carbamoyl phosphate synthetase, (165) 197 Carbamoyl phosphate synthetase I, (165) 133 Carbamoylation, (176) 426 Carbohydrate, (175) 249; (175) 443; (177) 17 Carbon fractionation, (178) 55 Carbon source, (165) 145 Carbonicanhydrase,(170) 117;(170)326;(173)41 Carbonic anhydrase B, (165) 88 Carbonic anhydrase III, (175) 129 Carbonic anhydrase isozyme, (165) 197 Carbonyl cyanide m-chloro-phenylhydrazone, (177) 11 Carbonyl cyanide p-tri-tluoromethoxyphenylhydraxone,

(177) 11 y-Carboxyghttamicacid, (165) 16; (168) 287; (173) 169; (177) 265 Carboxylase, (165) 16; (173) 169 Carboxylation, (177) 265 Carboxylic ionophore, (165) 133 Carcinogenesis, (178) 59 Cardiac conduction system, (178) 209 Cardiac glycoside, (173) 196 Cardiac light sarcolemma, (174) 50 Cardiodilatin precursor, (172) 80 Cardiotonic agent, (174) 15 Camitine, (176) 381 L-Camitine, (166) 33 I Carotenoid absorbance change, (178) 301 Cartilage, (169) 179 Casein, (169) 53 Casein kinase, (176) 479 Caseinkinasetype-2,(171)211 Casomorphin, (169) 53 Catabolite-activating protein-binding site, (177) 115 Catabolite repression, (177) 115 Catalase, (17 1) 309 Catalase Compound I, (177) 6 Catalyst conversion, (169) 287 Catalytic mechanism, (167) 235; (174) 96 Catalytic nucleotide-binding site, (174) 66 Catecholamine, (170) 49; (177) 143 Cathepsin, (170) 370 Cathepsin B, (174) 123 Cathepsin H, (166) 62 Cathepsin L, (174) 123 Cathepsin S, (174) 123 Cation, (169) 256 CD, (166) 258; (168) 10; (168) 174; (171) 145; (171) 207;

(173)209;(173)243;(175)227 CD measurement, (174) 310 Cdz+, (173) 124 Cell adhesion, (172) 17; (172) 326; (174) 279 Cell-cell interaction, (171) 107 Cellculture,(168)278;(169) 133;(169)261;(175) 199;(176)479 Cellcycle,(166)326;(167) 151;(168)65;(168)89;(169)211;

(172) 139; (177) 151 Celldivision,(173)319 Cell extract, (168) 245 Cell-free protein synthesis, (170) 339; (174) 253 Cell-free synthesis, (168) 255 Cell-free system, (174) 47 Cell-freetranslation,(l66)314;(170) 117;(174)238 Cell-free translation system, (178) 283

Volumes 165-178 (1984) 49

Cell fusion, (166) 223; (174) 61; (175) 13 Cell growth cycle, (173) 233 Cell proliferation, (165) 21; (171) 111 Cell regulation, (171) 101 Cell separation, (170) 232 Cell shape, (171) 107 Cell-size liposome, (176) 398 Cell-substratum adhesion, (168) 241 Cellsurface,(173)41;(173) 185 Cell surface property, (168) 89 Cell transformation, (174) 208 Cell wall, (166) 293 Cell wall acidification, (174) 223 Cell wall protein, (174) 284 Cellobiohydrolase, (167) 309 Cellular phenotype, (176) 8 Cellulase,(167)301;(167)309;(169)215 Cellulose, (172) 193 Cerebral fractionation, (174) 43 Ceruplasmin, (166) 232 Chalcone synthase, (172) 59 Chaotic response, (172) 235 Charge change, (176) 83 Chargeisomer, (167) 15 Chargemovement, (171) 89 Chelating agent, (171) 215; (177) 27 Chemical crosslinking, (166) 194 Chemical labeling, (176) 42 1 Chemicalmodification,(170)99;(171)253;(173)85;(176)255 Chemical shift correlation, (173) 342; (175) 259 Chemical synthesis, (176) 365 Chemiluminescent assay, (178) 47 Chemiosmotic hypothesis, (176) 79 Chemotactic peptide, (165) 171; (166) 165 Chemotactic receptor, (176) 245 Chemotaxis, (165) 171 Chilling sensitivity, (171) 55 Chiral methyl group, (171) 73 Chloramphenicol, (173) 5 2Xhloroadenosine, (167) 1; (175) 402 4’-Chlorodiazepam (Ro 5-4864), (176) 69 Chlorophyll a,,, (167) 316 Chlorophyll antenna, (170) 174 Chlorophyll b, (168) 10; (170) 174 Chlorophyll fluorescence, (167) 186 Chlorophyll-protein complex, (165) 151; (170) 174; (173) 209;

(176) 355 Chloroplast, (166) 23; (166) 233; (166)248; (166)253; (170) 121;

(171) 55; (171) 249; (172) 11; (172) 75; (172) 209; (174) 137; (174) 248; (175) 433; (176) 105

Chloroplast biogenesis, (166) 248 Chloroplast coupling factor 1, (166) 85 Chloroplast DNA, (177) 274 Chloroplast envelope, (167) 332; (168) 255; (169) 85; (178) 15 Chloroplast genome, (175) 173 Chloroplast membrane, (176) 133 Chloroplast protein synthesis, (166) 23 Chloroplast 5 S rRNA, (169) 67 Cholecystokinin, (166) 283 Cholecystokinin-8, (175) 124 Cholecystokinin-58, (174) 289 Cholecystokinin peptide, (174) 289

Cholera, (177) 104 Cholera toxin, (169) 241; (172) 91 Cholesterol, (168) 43 Cholesterol exchange, (175) 5 1 Cholesteryl Wmethylhexadecanoate, (177) 112 Choline& receptor, (178) 278 Choline& synapse, (166) 183 Cholinesterase inhibitor, (170) 147 Chou and Fasman’s method, (175) 267 ChromaEin cell, (169) 127 Chromatlin granule, (173) 119; (178) 20 Chromatin,(165)211;(168)313;(169)90;(177)241;(177)300,

(178) 143 Chromatin structure, (172) 70 Chromatofocusing, (167) 203 Chromatography, (172) 267; (175) 307 Chromosomal scaffold, (17 1) 13 Chromosome, (175) 37 Chromosome condensation, (167) 193 Chronic ethanol administration, (169) 274 Chymotrypsin, (168) 227; (178) 275 a-Chymotrypsin, (175) 178 Cibacron blue, (168) 79 Ciglitazone, (176) 49 Citrate, (169) 12 Citric acid cycle, (165) 145; (178) 245 cl-, (170) 350; (173) 36; (177) 2 Cl- efflux, (175) 193 Cl requirement, (168) 113 Cl- transport, (175) 337 Clathrin, (169) 127 Cleavage site, (170) 28 Clonidine, (170) 387 Cloning, (167) 92; (168) 103 a-Clostripain, (173) 58 CMV, (174) 38 CNBr cleavage, (170) 23 CNBr peptide, (170) 310 CO, compartmentation, (177) 138 CO2 fixation, (166) 233 CO2 production, (177) 217 Coagulation factor, (175) 412 Cobalt(H), (170) 326 a-Cobratoxin, (178) 64 Colchicine, (168) 278; (175) 63 Cold acclimation, (167) 10; (175) 402 Coldexposure,(175)402;(178)240 Cold stability, (169) 3 13 Colicin, (172) 183 Collagen, (168) 241; (170) 23; (174) 34; (174) 279; (176) 155 Collagen type II, (174) 238 Colloidal gold, (172) 193 Colloidal gold labeling, (165) 175 Colloidal particle, (167) 79 Color carboxymethylation, (165) 180 Comparative analysis, (175) 109 Comparative immunology, (175) 325 Compartmentalization, (178) 193 Compartmentation, (166) 32 1 Compartmentation-decompartmentation, (176) 401; (176) 406 Competitive binding, (173) 259 Competitive inhibition, (171) 221

50 Volumes 165-178 (1984)

Complement, (165) 111; (170) 254 Complement C,, (175) 63 Complement C-3, (169) 57 Complementary palindrome, (165) 72 Complete sequence, (167) 92 Compound 48/80, (166) 175; (175) 147 Computer data processing, (168) 7 Computer graphics model, (174) 102 Computer graphics modelling, (175) 387 ConcanavalinA,(l71)85 Conformation-function relationship, (170) 3 15 30 S Conformation, (173) 155 Conformational change, (166) 1 Conformational energy calculation, (174) 3 10 Conformational state, (178) 327 Conjugated tetraene, (177) 255 Conjugative plasmid transfer, (178) 97 Contraction control, (170) 383 Control strength, (177) 231 Conversion, (178) 92 Cooperative behavior, (170) 239 Cooperative binding, (170) 19 Cooperative enzyme, (168) 271 Cooperative interaction, (167) 339 Cooperativity, (170) 223; (171) 207 Coplanar base pair, (167) 245 Copper, (178) 127 Copper (I), (166) 288 Copper-containing amine oxidase, (170) 305 Copper ligand, (166) 288 Copper protein, (176) 378 Core particle, (169) 205 Core particle assembly, (167) 170 Corticosteroidogenicity, (173) 23 Corticotropin, (171) 179 Corticotropin precursor, (173) 222 Corticotropin RIA, (173) 222 Cortisol treatment, (165) 35 Cortisone induction, (177) 241 COSY, (169) 107 Cotranslational processing, (166) 314 Cotransport, (168) 327 Coulombic interaction, (167) 339 Coupling, (176) 365 Coupling factor 1, (171) 262 Covalent modification, (178) 199 Covalent structure, (177) 246 CPIa, (171) 47 Crassulacean acid metabolism, (178) 199 Creatine kinase BB, (167) 28 1 Crossbridge cycle, (174) 11 Crosslinking, (173) 90; (174) 116 cs+,(l73)301 CTP, (177) 112 Cucumber basic blue protein, (166) 288 Culture cell, (167) 254 Culture shock, (176) 8 Cyanide, (165) 293 Cyanide-sensitive factor, (169) 274 Cyanobacteria, (165) 67; (166) 160; (167) 321; (170) 85;

(171) 173; (172) 11 Cyanogen bromide fragmentation, (169) 57

Cyanomethemoglobin, (178) 31 Cyclic analog, (170) 3 15 Cyclic nucleotide, ( 168) 213 Cyclic peptide, (174) 3 10 Cyclic voltammetry, (166) 76 Cycloheptapeptide, (173) 53 w-Cyclohexane fatty acid, (172) 331 Cystatin C, (170) 370 Cysteine, (167) 235; (171) 257; (177) 295; (178) 271 Cysteine proteinase, (170) 259; (170) 370; (173) 58; (174) 123 %-Cysteine proteinase inhibitor, (166) 62 Cystine, (178) 271 Cytidine triphosphate, (165) 121 Cytochrome, (167) 339 Cytochromea,, (171) 309 Cytochromea%, (170) 301 Cytochrome b, (166) 367; (172) 261; (175) 100; (178) 343 Cytochrome bs, (172) 255 Cytochrome b-5, (169) 143 Cytochrome b-559, (165) 156 Cytochrome b-559, (176) 239 Cytochrome b-561, (178) 336 Cytochrome bc complex, (168) 149 Cytochrome bc, complex, (172) 205; (177) 47 Cytochrome bc:, site inhibitor, (172) 261 Cytochrome b-f complex, (174) 137 Cytochrome b,-f complex, (172) 255 Cytochromec, (166) 131; (166) 362; (177) 287 Cytochrome c binding domain, (173) 374 Cytochrome c heme peptide, (178) 47 Cytochromec-oxidase, (166) 131; (166) 362; (172) 189 Cytochrome c-oxidase isozyme, (173) 374 Cytochromec-554, (170) 331 Cytochrome cc (174) 219 Cytochrome oxidase, (168) 1 Cytochrome oxidase assembly, (177) 29 1 CytochromeP-450,(167) 131;(169)7;(172)279;(173)287 Cytochrome P-450a2,, (167) 131 Cytokeratin, (171) 107 Cytoplasm, (174) 248 Cytoplasmic phosphoprotein, (173) 337 Cytosine-specific reaction, (166) 194 Cytoskeleton, (169) 161; (169) 323; (172) 309; (173) 19; (173) 164;

(174) 7; (176) 313; (176) 325 Cytosolic acidification, (174) 223

DABTH-amino acid, (176) 360 Dantrolene, (167) 123 Daudicell,(l71) 111 Daunorubicin, (173) 27 Deaminofolate, (176) 325 Debrisoquine polymorphism, (173) 287 Decapping activity, (166) 57 Dehydrogenase, (165) 6; (175) 68 16-Dehydropregnenolone, (167) 103; (174) 173 Deiodination, (177) 221 Dendrotoxin, (174) 116 Denervation, (172) 114 Denitrification, (168) 321; (172) 205 Deoxyglucose, (173) 19 2-Deoxyglucose, (176) 16 Deoxyribonuclease I, (167) 155

Volumes 165-178 (1984) 51

Deoxyribose degradation, (167) 37; (172) 245 Dephosphorylation, (167) 291 Desensitization, (177) 227 (-)-PHlDesmethoxyverapamil, (176) 371 Detergent, (170)243; (171) 169; (174) 279; (176) 351; (177) 221 Detoxication, (169) 156 Detoxification, (170) 73 Deuterated protein, (175) 364 Development, (171) 240; (172) 315; (177) 300, (178) 137 Diabetes,(l70)23;(173) 173;(176)49 Diacylglycerol, (167) 42; (176) 93 Diacylglycerol activated, (166) 125 Dialnucleotide, (169) 101 Diarylpropane, (169) 247 Diazepam, (173) 255; (176) 69 cis-Dichlorodiammineplatinum, (169) 30 2,4-Dichlorophenol hydroxylase, (173) 314 2,6-Dichlorophenolindophenol reductase, (170) 157 2,4-Dichlorophenoxyacetate degradation, (173) 314 2,4-Dichlorophenoxyacetate plasmid, (173) 307 Dicoumarol, (169) 63 PT]-N’,N’-Dicyclohexylcarbodiimide, (169) 283 Diene conjugation, (171) 320 Diet change, (174) 211 Dietary antioxidant, (169) 63 8-(N,N-Diethylamino)octyl-3,4,5-trimethoxy-benzoate,

(176) 139 Diethylpyrocarbonate, (167) 235 Difference absorption spectrometry, (175) 249 Differential spectroscopy, (178) 288 Differentiation, (165) 265; (165) 277; (168) 222; (170) 139;

(170) 152; (173) 19; (177)66 Differentiation factor, (178) 291 Differentiation induction, (176) 250 Diffusion potential, (178) 301 a-Difluoromethylomithine, (171) 221 Digestion, (166) 155 Digitonin/deoxycholate particle, (174) 24 I-Dihydroalprenolol, (169) 15 1 Dihydrodiol dehydrogenase, (170) 263 Dihydrofolate reductase, (175) 364, (178) 306 Dihydropyridine, (167) 88 l&Dihydropyridine, (169) 112 Sa-Dihydrotestosterone, (170) 114 Dihydroxyacetone-phosphate acyltransferase, (169) 35;

(176) 264 24R,25-Dihydroxycholecalciferol, (167) 28 1 1,25-Dihydroxyvitamin D, (174) 30 1,25-Dihydroxyvitamin D3, (169) 49; (170) 239 la,25-Dihydroxyvitamin Dr, (174) 61 Dimer structure, (178) 101 Dimethylmaleic anhydride, (172) 70 Dimethylsulfoxide, (165) 277 Dimethylsulfoxide-induced differentiation, (176) 467 Dimyristoylphosphatidylcholine, (171) 160 2,4-Dinitrophenol inhibition, (171) 79 Dipeptide, (171) 227 Dipeptidyl aminopeptidase, (173) 199 Dipeptidyl carboxypeptidase, (170) 281 2,3_Diphosphoglycerate, (17 1) 187 Directed cleavage, (172) 43 Disease resistance, (172) 59

Dissimilatory nitrite reduction, (172) 205 Distribution-free plot, (176) 325 Disulfide, (174) 128 Disulfide exchange, (178) 114 Disulfide-linked subunit, (166) 109 Disulfide switch, (171) 257 Disulfonic stilbene, (175) 275 Dithiothreitol, (171) 137; (177) 221 Diuresis, (167) 352 Diurnal rhythm, (178) 199 Divalentcation,(l67)295;(169)251 DNAbinding,(l65)35;(170)99;(172) 172 DNA-binding domain, (168) 275 DNA-binding protein, (165) 39; (170) 143; (174) 243; (176) 176 DNA-binding protein II, (175) 208 DNA cleavage, (172) 23 1 DNA (cytosine-5-hnethyltranferase, (178) 59 DNA damage, (174) 147 DNA duplex, (167) 147 DNA folding, (172) 70 DNA hypomethylation, (176) 250 DNA injection, (165) 31 DNA intercalation, (169) 123 DNA isolation, (174) 215 DNA melting, (172) 172 DNA-melting profile, (169) 30 DNA methylase, (168) 166; (178) 59 DNAmethylation,(l73)233; (176)250,(177)81; (178)217 DNA oligonucleotide, ( 175) 117 DNA packing, (165) 238 DNA plant virus, (165) 285 DNA polymerase I, (178) 223 DNA-Pt, (176) 389 DNA-Pt complex, (173) 95 DNA purification, (169) 305 DNA repair, (178) 223 DNAreplication,(l68)65;(171) 111; (173) 351;(176)431;

(178) 153 DNA replication in vitro, (171) 5 DNA-scaffolding protein, (170) 99 DNA sequence, (167) 165; (168) 103; (169) 73; (171) 197;

(171) 297; (173) 264, (177) 260, (177) 274 DNA sequencing, (165) 185; (177) 57 DNA synthesis, (168) 313; (169) 185; (174) 61 DNA synthesis inhibition, (17 1) 9 DNA topoisomerase, (177) 300 chloroplast DNA, (166) 307 circular DNA, (172) 67 complementary DNA, (173) 108 kinetoplast DNA, (168) 139 lithiumB-DNA,(l76) 110 plastid DNA, (176) 239 recombinant DNA, (166) 67 repetitive DNA, (169) 305 SV4ODNA,(l73) 151 z-DNA, (168) 302 complementary DNA cloning, (166) 67 repetitive DNA sequence, (176) 250 single-stranded DNA sequence, (168) 166 IDNAsequence,(l77) 115 cloned cDNA, (178) 240 mtDNA, (172) 67

52 Volumes 165-178 (1984)

Endogenouscation, (171) 215 Endogenous modulator, (171) 280 Endoglucanase, (167) 30 1 Endopeptidase, (166) 32 1 Endopeptidase-24.11, (175) 124 Endorphin, (175) 407 a-Endorphin, (166) 267 y-Endorphin, (166) 267 /I-Endorphin fragment, (166) 267 Endothelial cell, (170) 109 &Endotoxin, (168) 197 bEndotoxin gene, (175) 377 Endplate region, (174) 267 Enediol, (170) 355 Energized state, (175) 433 Energy barrier, (173) 301 Energy calculation, (170) 3 15 Energy conservation, (169) 300 Energy coupling, (176) 79 Energy profile, (170) 191; (173) 301 Energy transfer, (174) 304; (176) 27 Enhancer element, (175) 152 Enkephalin, (172) 303 Enkephalin degradation, (166) 183 5-Enolpyruvylshikimate 3-phosphate synthase, (165) 117;

(170)59;(173)238 Enterotoxin, (169) 241; (177) 104 Entrainment, (172) 235 Envelope membrane, (169) 283 Enzymatic oxidation, (176) 321 Enzymatic reduction, (176) 32 1 Enzyme IIsiWosc, (170) 55 Enzyme activation, (170) 76; (174) 275 Enzyme activity, (166) 298; (170) 152 Enzyme adsorption, (172) 193 Enzyme conformation, (174) 96 Enzyme deactivation, (169) 97 Enzyme differentiation, (174) 123 Enzyme inactivation, (165) 265; (169) 101; (170) 162; (176) 421 Enzyme inhibition, (165) 197; (173) 238 Enzyme inhibitor, (167) 273 Enzyme inhibitor homology, (167) 210 Enzyme labeling, (172) 193 Enzyme latency, (171) 271 Enzyme location, (177) 138 Enzyme marker, (174) 43 Enzyme mechanism, (176) 378 Enzyme modification, (165) 6 Enzyme modulation, (172) 11 Enzyme phosphorylation, (175) 55 Enzymepurification,(l69)215 Enzyme purification, (171) 141; (173) 327 Enzyme solubilization, (172) 47 Enzyme specificity, (168) 227; (170) 295; (174) 102 Enzyme stabilization, (169) 97 Enzyme structure, (167) 285 Enzyme-substrate complex, (175) 356 Enzyme synthesis, (168) 222 Eosinophil, (168) 23 Eosinophil peroxidase, (174) 300 Epidermal growth factor, (166) 136 Epinephrine, (170) 310

rDNA, (171) 297 DNaseI, (167) 170;(176) 313 DNase I digestion, (169) 165 DNaseassay,(l74)215 EDTA-activated DNase, (174) 215 Dodecyl sulfate, ( 170) 8 1 Dolichol, (169) 279 Domain structure, (17 1) 145 Donor component D,, (169) 219 Dopamine, (166) 189; (177) 249 Dopamine+hydroxyla, (165) 128 D,-Dopamine receptor, (166) 389; (176) 436 Dopaminergic agent, (175) 407 Dot immunobinding assay, (175) 333 Double-helical decanucleotide, (176) 393 Double helix, (165) 5 1 Double-inhibitor titration, (176) 79 Double-strand specific nuclease, (176) 255 2,3-DPG binding, (176) 331 Drug targeting, (167) 79; (178) 109 Duodenal juice, (171) 320

E, component, (172) 38 East Coast Fever, (169) 305 Ecdysterone, (168) 235 Echinocandin, (173) 134 EcoRII cleavage, (167) 147 Edeine-resistant mutant, (174) 47 Edman degradation, (176) 365 EDTA, (177) 157 Elastic response, (175) 299 Elasticity, (177) 205 Electric organ membrane, (166) 183 Electrochemical detection, (170) 69 Electrochemical gradient, (173) 19 Electrochemistry, (166) 76 Electrochromic absorption change, (176) 83 Electrochromic bandshift, (177) 11 Electrode modification, (166) 76 Electrofusion, (173) 331 Electrogenic Na+/K+ pump, (175) 275 Electrogenic process, (178) 336 Electrogenic proton pump, (168) 15 Electron acceptor, (177) 287 Electronmicroscopy,(l67)285;(170)335;(172)67;(172) 193;

(173)217;(178)20 Electron transfer, (166) 131; (166) 362; (167) 316; (174) 157 Electron transport, (166) 233; (167) 231; (168) 149 Electronic spectroscopy, (178) 51 Electrophoresis,(l65)211;(170) 174 Electrophoretic mobility, (172) 294 ELBA, (167) 15 Elongation cycle, (165) 280 Elongation factor G, (171) 202; (176) 32 Elongation factor Tu, (165) 175; (176) 313 Elongation factor 1, (176) 401 Elongationfactor2,(173) 113;(176)261;(176)406 Elongation hypothesis, (177) 1 Embryogenesis, (168) 161; (172) 163 Endo F, (166) 28 Endocellulase, ( 169) 2 15 Endocytosis, (178) 109

Volumes 165178 (1984)

Epoxide hydrolase, (171) 127 Epoxyeicosatrienoic acid, (178) 3 19 Epoxygenase, (178) 319 EPR,(l65) 156;(165)293;(166)378;(173)259;(177)277 EPR multiline signal, (176) 346 Mn-EPR, (174) 157 S2 multiline EPR signal, (174) 157 Erythrocyte differentiation, (166) 263 Erythroid differentiation, (176) 88 ESR, (169) 279; (172) 239; (173) 283; (176) 378; (178) 288 Esterase, (166) 347 Esterase activity, (170) 375 Estrogen, (175) 41; (178) 217 Estrogen-induced protein, (167) 281 Ethanol, (172) 177 Ethanol tolerance, (172) 299 Ethanolamineend, (170) 191; (173) 301 Ether phospholipid, (165) 273; (166) 115 Ethidium bromide, (173) 243 5’-N-Ethylcarboxamideadenosine, (172) 335 1-Ethyl-3-(3-dimethyl-aminopropyl)carbodiimide, (173) 374 Ethylene, (167) 64, (169) 247; (172)47; (173) 139 Ethylene-forming enzyme, (173) 139 N-Ethylmaleimide, (170) 69 Etiolated leaf, (167) 186 Eubacteria, (177) 189 Eukaryote, (177) 189 Evolution, (168) 97; (168) 293; (169) 67; (171) 63; (172) 289;

(176) 462; (177) 189; (178) 79 Excitable membrane, (167) 113; (171) 95 Excited triplet state, (177) 287 Exo-cellobiohydrolase, (169) 215 Exocytosis, (175) 147 Y-5 Exonuclease, (178) 223 Exopeptidase, (166) 321 Extended conformation, (170) 229 Extracellular matrix, (172) 17

Factor IIIrrums, (170) 55 Factor IX, (165) 102 Factor X, (165) 102 FAD, (178) 87 Familial hypercholesterolemia, (173) 159 Fast atom bombardment, (174) 151 Fatty acid, (166) 331; (170) 1; (175) 284; (178) 55 Fatty acid synthesis, (166) 151; (175) 8; (177) 217 Fatty acyl-CoA desaturase, (169) 274 Fc receptor, (171) 37 Fe’ + chelate, (172) 11 Fe-N,(His) stretching, (178) 31 Fe-protein, (173) 394 3-Fe center, (165) 227 4-Fe center, (165) 227 [3Fe] cluster, (167) 137 3Fe core, (169) 79 4Fe core, (169) 79 [4Fe4S] cluster, (173) 15 Feed-back control, (165) 11 Fenton reaction, (172) 245; (177) 27 Ferredoxin,(l65)227;(166)76;(166)81;(167) 137;(169)79;

(173) 15;(173)204 Ferredoxin-dependent reductase, (170) 85

53

Ferredoxin-NADP+ oxidoreductase, (170) 85 Ferredoxin-NADP reductase, ( 166) 8 1 Ferredoxin-NADP+ reductase, (174) 137 Ferrichrome, (173) 53 Ferritin, (165) 63; (165) 243; (175) 333; (176) 97; (177) 27 Ferritin turnover, (165) 243 Ferroxidase activity, (166) 232 Ferulic acid 5-hydroxylase, (169) 7 Fetal wastage, (178) 87 a-Fetoprotein, (175) 41 Fiber diffraction, (176) 110 Fibrinolysis, (175) 412 Fibroblast,(lll) 117;(174)34 Fibroblast culture, (173) 159; (174) 71 Fibronectin, (168) 313; (171) 131; (171) 285; (174) 279: (176) 169;

(178) 327 Field desorption, (174) 15 1 Filament, (178) 264 Filamin, (178) 311 Fingerprinting, (169) 17 Flagellin, (171) 145 Flash spectroscopy, (175) 337 Flavin, (178) 87 Flavin hydroquinone, (170) 85 Flavin semiquinone, (170) 85 Flexibility, (168) 174 Flow-gash photolysis spectrophotometry, (166) 362 Flow linear dichroism, (169) 309 Fluidity,(l67)69;(169) 1;(172)6 F1uorescence,(165)79;(169)205;(171)47;(172)267;(173) 155;

(176) 27; (176) 144; (176) 365 Fluorescence kinetics, (169) 229 Fluorescence lifetime, (165) 107 Fluorescence polarisation, (172) 103 Fluorescence polarization, (165) 238 Fluorescent dye, (176) 421 Fluorescentindicator, (170)43; (170) 181 Fluorescent pH probe, (166) 120 Fluorescent phospholipid probe, (173) 291 Fluorescent probe, (165) 67; (169) 169; (174) 199 9-Fluoro-9-deoxy-N-acetylneuraminic acid, (170) 295 Fluorography, (170) 23 Fluoroimmunoassay, (173) 213 Folate receptor, (176) 325 Folding, (178) 114 Folding intermediate, (165) 88 Follicle-stimulating hormone, (168) 49 Follicle-stimulating hormone release, (175) 349 Footprinting, (176) 414 Footrot, (173) 103 Formaldehyde, (170) 73 Formate, (177) 6 Formycin triphospate, (175) 45 N-Formyl blocking group, (174) 15 1 Formylpeptide, (165) 171; (176) 151 N-Formylpeptide receptor, (167) 277 Forskolin, (170) 273; (173) 407; (177) 17 FPLC, (169) 287 Free energy coupling, (177) 146 Free energy transduction, (165) 1; (166) 1 Free fatty acid, (171) 55 Free radical, (170) 162; (171) 320; (174) 147; (176) 337; (176) 378

54 Volumes 165-178 (1984)

Freeze thawing, (176) 385 Frog eye lens, (171) 297 Fructose I,6bisphosphate, (167) 199 Fructose 2,bbisphosphate, (167) 199; (167) 203; (169) 12;

(171) 117;(172)51;(175)369;(176)484 Fructose-1,6-bisphosphatase, (167) 199, (167) 203 Fucolipid, (167) 47 Fucose, (172) 339 Fucosyltransferase, (174) 43 Functional deficiency, (173) 287 Functionally-active ribosome, (178) 283 Fusion polypeptide, (173) 108

Cl, arrest, (167) 151; (172) 139 Galactolipase activity, (171) 55 Galactolipid, (17 1) 55 Galactosyltransferase activity, (168) 222 Ganglioside, (170) 391; (172) 339 Gas chromatography-mass spectrometry, (167) 103 Gastric inhibitory peptide, (172) 142 Gastric inhibitory polypeptide, (168) 125 Gastrointestinal peptide, (177) 104 GC-MS, (172) 279; (174) 173 GDP binding, (176) 313 GDP[BS], (165) 290 Gel electrophoresis, (170) 81 Gel filtration, (168) 125; (172) 172 Gel filtration chromatography, (169) 199 Gelsolin, (167) 52; (174) 80 Gene A protein, (173) 351 Gene cloning, (171) 197; (173) 103; (175) 343; (175) 377 Gene-dosage regulation, (173) 31 Gene duplication, (168) 103 Geneexpression,(170)320;(173)31;(177)61 Gene family, (175) 37 Gene fusion, (176) 179; (178) 306 Gene regulation, (170) 114 Gene transfer, (175) 152 1 Gene regulation, (177) 115 aroA Gene, (165) 121; (170) 59 crp Gene, (170) 320 fnr Gene, (170) 320 iap+ Gene, (175) 343 ksgAGene,(l77) 119 General phenylpropanoid metabolism, (172) 59 Gila monster venom, (166) 273; (166) 277; (166) 283; (172) 55;

(172) 284; (178) 233 Glibenclamide, (177) 135 Globo-series structure, (175) 397 Glucagon, (168) 317; (169) 203; (177) 6; (178) 83; (178) 143 Glucagon-like peptide 1, (178) 83 Glucagon-like peptide 2, (178) 83 1,4-/J-D-Glucan cellobiohydrolase, (172) 193 1,3-/3-D-Glucan synthase, (173) 134 Glucan synthetase II, (171) 271 1,3-/?-D-Glucanase, (173) 134 Glucocorticoid, (171) 121; (173) 129; (177) 89; (178) 1 Glucocorticoid receptor, (165) 35; (171) 121 Glucocorticoid steroid, (174) 143 Glucolysis, ( 17 1) 117 Gluconeogenesis, (173) 407 Glucose, (170) 196; (170) 365; (176) 457

Glucose dehydrogenase, (165) 6 Glucose dependence, (168) 125 Glucose load, (172) 149 Glucose localization, (170) 23 Glucose permeability, (172) 149 Glucose phosphorylation, (172) 149 Glucose synthesis, (165) 247 Glucose transport, (167) 5; (176) 49 Glucose uptake rate, (172) 149 D-[1-rT]Glucose, (178) 34 Glucosylation, (173) 173 p-D-Glucuronidase, (176) 61 Glutamate, (173) 295; (177) 249 Glutamate binding, (175) 3 1 Glutamate dehydrogenase, (171) 59 Glutamate mutase, (171) 73 Glutamate receptor, (175) 31 Glutamate synthase, (173) 204 Glutamate transport, (175) 3 1 (ZS)-Glutamate, (171) 73 (S)-Glutamate dehydrogenase (NAD), (171) 79 Glutamine synthetase, (17 1) 59; (175) 443 Glutathione,(l68)293;(178)119;(178)271 Glutathione biosynthesis, (176) 189 Glutathione S-transferase, (169) 156; (177) 3 1 Glutathione transferase, (175) 289 Glutathione transferase E (5-5) (173) 327 Gluten protein, (177) 205 Glycan polymerase, (168) 155 Glycation, (173) 173 Glyceraldehyde-3-phosphate dehydrogenase, (171) 137 Glycerol-ether lipid, (169) 35 Glycerophosphate acyltransferase, (176) 264 Glycerophosphodiester, (170) 1 Glycerophospholipid, (170) 1 Glycerophosphorylcholine, (176) 88 Glycoconjugatereceptor, (168) 197 Glycogen metabolism, (169) 45; (173) 407; (178) 34 Glycogen phosphorylase, (165) 247 Glycogen phosphorylase kinase, (166) 335; (169) 224 Glycogen synthase, (170) 310; (170) 365; (172) 294; (175) 55 Glycogen synthesis, (167) 1; (170) 49 Glycogen synthesis rate, (172) 149 Glycogenesis, (175) 8 Glycogenolysis, (165) 247; (167) 295; (169) 203; (175) 8 Glycolipid, (167) 47; (172) 339; (173) 80; (174) 1 Glycolipid receptor, (170) 15 Glycolysis, (167) 1; (167) 83; (172) 235; (176) 16; (176) 484 Glycophorin A, (176) 385 Glycopolypeptide, (166) 293 Glycoprotein, (169) 194; (171) 9; (173) 63; (173) 185; (178) 291 Glycosidase inhibitor, (176) 61 Glycosidic cleavage, (173) 27 N-Glycosidic glycan, (170) 343 Glycosome, (169) 35 Glycosphingolipid, (174) 55 Glycosylation, (175) 443 Glycosylation site, (169) 194 Glycosyltransferase, (167) 47 Glyoxylate cycle, (165) 255 Glyphosate, (165) 121; (170) 59 Glyphosate resistance, (173) 238

Volumes 165-178 (1984) 55

cyclic GMP, (175) 87 cyclicGMPaggregation,(171)315 Goldlabeling, (177) 184 Gossypol, (175) 41 Gramicidin A, (165) 51; (170) 191; (173) 301 Gramicidin S, (174) 3 10 Green rod pigment, (175) 87 Growthcontrol, (167) 151; (172) 139 Growth factor, (169) 189; (170) 391 Growth hormone, (166) 189; (166) 352; (167) 15 Growth hormone releasing factor, (166) 189; (172) 55 G,/S transition, (166) 326 GTP,(l65)290;(173) 134;(177) 112;(177) 125 GTPanalog,(l75)313 GTP binding, (173) 67; (175) 313 GTP-binding protein, (168) 121; (168) 213; (176) 473; (178) 228 GTP catabolism, (165) 207 GTP hydrolysis, (178) 283 GTP-induced assembly, (178) 264 GTPase, (166) 165; (171) 233; (174) 233; (177) 112 Guanidine-HCl, (170) 8 1 Guanine nucleotide, (167) 142; (173) 385; (174) 50; (174) 90 Guanine nucleotide binding, (166) 141 Guanine nucleotide-binding protein, (172) 91; (172) 321;

(173) 414 Guanine nucleotide regulation, (170) 38 Guanine nucleotide-regulatory protein, (167) 142 Guanosine, (176) 43 Guanylate cyclase, (171) 95 Guanylate reductase, (165) 207

H+ translocation, (169) 300 H+ transport, (169) 283; (174) 233 Haber-Weiss reaction, (177) 27 Half-of-the-sites reactivity, (167) 269 Halorhodopsin, (175) 337 Halothane, (167) 123 Haptoglobin, (168) 103; (171)85;(171) 131 HDL, (173) 173; (173) 291; (175) 159 HDL metabolism, (170) 109 H’je- stoichiometry, (169) 300 Heat activation, (171) 262 Heat shock, (169) 267; (172) 299; (178) 149 Heat shock protein, (176) 8 Helium-neon laser, (175) 95 Helix topology, (174) 243 a-Helix, (166) 33; (173) 403; (175) 263; (176) 355 a-Helix packaging, (166) 33 Helodermin, (166) 273; (166) 277; (172) 55; (178) 23 1 Hematoporphyrin derivative, (177) 295 Heme, (166) 298 Heme a requirement, (177) 291 Heme-binding site, (165) 293; (166) 367 Heme release, (169) 147 Heme structure, (178) 165 Heme transport, (178) 213 5-coordinate Heme, (170) 33 1 Hemin, (166) 298; (167) 339 Hemocyanin, (165) 223 Hemoglobin, (166) 378; (169) 147; (171) 187; (178) 165 Hemoglobin o;jJ, contact, (173) 45 Hemoglobin/3-chain, (176) 331

Hemoglobin B-chain fragment, (170) 28 Hemoglobin Aichi [aSO(CEI)His-+Arg], (169) 297 Hemoglobin Marseille, (178) 3 15 Hemoglobin Okazaki, (173) 45 Hemoglobin S, (173) 259 Hemoglobin variant, (166) 8; (176) 331 Hemoglobinopathy, (172) 155; (178) 3 15 &Hemolysin, (169) 25 Hemolysis, (176) 207; (178) 127 Hemopexin, (178) 213 Heparan sulfate, (168) 313; (173) 75; (174) 279 Heparin, (169)45; (171) 157 HeparinSepharose, (169) 45 Hepatocyte-stimulating factor, (177) 89 Herbicide, (165) 156; (167) 321; (175) 243 Herbicide inhibitor, (167) 327 Hereditary fructose intolerance, (165) 247 Heteronuclear decoupling, (173) 342; (175) 259 Heteropentalene, (172) 239 Hexaamineruthenium, (175) 100 Hexachlorocyclohexane, (176) 15 1 Hexose transport, (174) 71 HHH syndrome, (170) 13 1 High-affinity radioligand, (176) 436 Highmannose glycoprotein, (177) 179 High mobility group protein, (169) 174 Highmobilitygroupprotein 1,(172) 172;(178) 153 High-pressure dissociation, (173) 381 High-pressure enzyme kinetics, (169) 97 High-spin heme, (165) 293 Hirudin, (165) 180; (177) 109 Histamine Hr receptor, (177) 227 Histamine secretion, (173) 414; (175) 147 Histidine, (166) 288; (167) 235 distal Histidine, (166) 378 Histochemistry, (177) 5 1 Histone, (168) 313; (178) 143 Histone dissociation, (172) 70 Histone gene, (168) 65; (168) 249 HistoneHl, (167) 291; (170) 19; (175) 321 HistoneH1”,(166)263 Histone H2A, (172) 70; (176) 426 Histone H2B, (172) 70 Histone H5, (166) 263 Histone-like protein, (172) 75 Histone tail, (169) 90 HrO, reaction, (173) 27 Homology, (166) 347 Hormonal effect, (170) 310 Hormonal responsiveness, (176) 8 Hormone acceptor, (177) 241 Hormoneaction,(l66) 125;(170) 114;(171) 121;(178)73 Hormone precursor, (177) 175 Hormone receptor, (170) 360; (172) 87 HPLC, (165) 11; (165) 46; (166) 85; (167) 33; (167) 59; (168) 299;

(169) 53; (169) 143; (172) 155; (172) 279; (173) 222; (173) 307; (175) 140; (176) 360, (178) 315

Human factor D, (166) 347 Hyaluronic acid degradation, (177) 27 Hybrid protein, (172) 183 Hybridization, (174) 238 Hydra head activator, (173) 307

56 Volumes 165-178(1984)

Hydrazine-bisulfite, (166) 194 Hydrocortisone, (172) 25 Hydrodynamic diameter, (175) 329 Hydrodynamics, (166) 258 Hydrogen peroxide, (169) 247 Hydrolysis activation, (175) 433 Hydropathy, (176) 239 Hydroperoxylinoleic acid, (172) 231 Hydrophilicity, (168) 143 Hydrophobic group, (173) 347 Hydrophobic labeling, (168) 23 1 Hydrophobic moment, (175) 263 Hydrophobic polypeptide, (166) 223 Hydrophobicity, (170) 268 Hydrophobic&y profile, (175) 267 (2R)-Hydroxy-acid preparation, (167) 29 p-Hydroxyaspartic acid, (165) 102 p-Hydroxybutyrate dehydrogenaae, (168) 271 Hydroxyl radical, (167) 37; (172) 245; (177) 295 Hydroxylation, (168) 287 3a-Hydroxysteroid dehydrogenase, (170) 263 Hydroxysterol, (173) 319 5Hydroxytryptamine uptake, (171) 280 Hyperallostery, (175) 294 Hypertension, (170) 387 Hypomethylation of DNA, (176) 250 Hypophysectomy, (175) 129 Hypothalamic obesity, (166) 151 Hypothalamus, (178) 83

Identifier sequence, (174) 208 u-L-Iduronidase, (176) 61 Imageaveraging,(l73)217 Iminoproton,(l65)216 Imipramine, (171) 280 Immobilization, (175) 178 Immobilized enzyme, (175) 299 Immunoassay, (166) 67; (173) 213; (174) 253 Immunoblotting, (166) 263; (167) 15; (169) 90; (171) 192;

(172) 189; (172) 303;(177) 189 Immunocytochemistry, (166) 71; (168) 33; (177) 51 Immunoelectron microscopy, (165) 175 Immunofluorescence, (167) 52 1mmunog1obu1in,(171)37;(175)152 Immunoglobulin A, (168) 203 Immunoglobulin G, (173) 204 Immunoglobulin isotype, (171) 41 Immunoglobulin M, (170) 343 Immunolabeling, (170) 232 Immunological comparison, (17 1) 249 Immunoneutralization, (178) 87 Immunoprecipitation, (170) 117 Immunoreactive gastric inhibitory polypeptide, (168) 125 Inclusion body, (177) 179 Indium, (166) 202 Indoleacetic acid, (174) 223 Indomethacin, (166) 136 Induction, (178) 323 Inflammation, (176) 155; (178) 25 Infrared dichroism, (176) 355 Inhibin, (176) 21 Inhibin fragment, (167) 98

&Inhibin, (175) 349 Inhibitor, (167) 64; (170) 326 Inhibitor-l, (169)45 Inhibitory regulatory component (NJ, (171) 233; (175) 25 Initiation factor, (175) 203 Initiation factor-2, (175) 313 30 S Initiation complex, (175) 203 Inorganic carbon uptake, (176) 166 Inorganic pyrophosphatase, (165) 25 1; ( 167) 269 myo-Inositol, (170) 165; (171) 179; (172) 99 Inositol phosphate, (176) 411 Inositol phospholipid, (170) 43 Inositoll,4,5-t&phosphate, (176) 193 Insecticide, (168) 197; (173) 147; (175) 377 Insectotoxin &A, (165) 57 Insulin, (167) 5; (167) 25; (168) 299; (176) 484; (177) 217;

(178) 132 Insulin action, (170) 360 Insulin-like growth factor I, (173)48 Insulin mediator, (176) 411 Insulinreceptor,(l75)113;(176)49;(176)229 Insulinrelease,(l76)457;(177) 17;(177) 135 Insulin resistance, ( 167) 1; (176) 49 Insulin secretion, (170) 196; (175) 393 Insulin sensitivity, (167) 1; (175) 68; (175) 402 Insulin stimulation, (177) 217 Insulinotropic peptide, (168) 125 Integral membrane glycoprotein, (172) 326 Integral transmembrane protein, (172) 343 Integration, (169) 211 Intercalation, (172) 6 Interconversion, (175) 369 Interfacial behavior, (173) 95 Interferon,(l68)208;(171) 111;(175)227;(177)99 Interferon action, (166) 3 11 Interferon induction, (167) 226 y-Interferon, (175) 325; (178) 257 Interleukin-2, (170) 391 Intermediate, (178)92; (178) 114 Intermediate filament, (170) 81; (171) 107 Internal homology, (167) 221 Interprotondistance,(l65)216;(175) 117 Interrupting sequence, (168) 249 Intestinal extract, (170) 28 Intestinal receptor, (170) 239 Intestinal secretion, (177) 104 Intestinal transport, (174) 30 Intracellular messenger, (176) 193 Intracytoplasmic pool, (175) 189 Intron, (168) 143 Intron-exon junction, (174) 102 Invertebrate photoreceptor, (168) 213 Inverted repeat, (166) 307 Inverted thylakoid vesicle, (168) 113 Iodination, (175) 140 Iodine, (176) 337 Iodothyronine, (177) 221 Ion channel, (165) 51; (166) 146; (178) 20 Ion channel element, (172) 1 Ion efflux, (176) 457 Ion pairing, (173) 85 Ion-selective electrode, (166) 175

Volumes 165-178 (1984)

Ion transport, (176) 1 Ionic strength effect, (166) 362 IonophoreA23187,(170)64;(175) 165;(177)76 Iron, (165) 243; (177) 27 Iron dextran, (170) 232 Iron metabolism, (165) 63 Iron protein, (165) 63 Iron-sulfur, (169) 79 Iron-sulfur cluster, (177) 47 Iron-sulfur protein, (174) 24 Irreversible inhibitor, (174) 275 Islet-activating protein, (167) 5; (171) 233; (173)414 Isobutylmethyl xanthine, (167) 1 Isocitrate dehydrogenase, (165) 255; (172) 289; (174) 112;

(177) 143 Isocratic separation, (176) 360 Isoelectin, (175) 76 Isoelectric focusing, (169) 156 Isoenzyme, (170) 326; (175) 289; (178) 249 Isoenzyme difference, (173) 367 Isoferritin, (165) 63; (165) 243 Isoflavone, (175) 199 Isoform, (173) 204; (175) 443 Isohormone, (169) 21 Isolate identification, (168) 139 Isolate-specific minicircle, (168) 139 Isolectin, (176) 120 Isoleucine, (166) 357 Isoleucyl-tRNA synthetase, (171) 245; (173) 264; (174) 20 Isoprenaline, (167) 5 Isoschizomer, (173) 99; (177) 57 Isothiocyanate, (176) 365 Isotope labeling, (166) 202 Isozyme, (169) 156; (172) 294 Isozyme conversion, (175) 343 L Isozyme, (171) 293 M, Isozyme, (171) 293

Juvenile hormone esterase, (171) 127 Juvenile hormone receptor, (171) 127

K+,(171)95;(173)301 K+ depolarization, (175) 147 K+ effect, (166) 258 K+ release, (173) 196; (178) 44 intracellular K+ activity, (174) 211 Kallikrein, (175) 412 Kallikrein autolysis loop, (175) 1 Karyophilic protein, (170) 125 Kasugamycin, (177) 119 Keratin, (178) 92 Keratinization, (178) 92 Ketanserin, (17 1) 289 a-Ketoacid decarboxylase, (176) 334 Kinase activity, (175) 387 Kinase inhibitor, (177) 36 Kinase/activator, (176) 115 Kinetic, (166) 62 Kinetic parameters, (168) 327 Kinetics, (168) 260; (170) 19; (175) 203; (175) 289; (176) 351 Klenow fragment, (178) 223 Kringle,(171) 131

57

Kupffercell,(171) 149;(177)89

&La&am, (170) 268 BLactam antibiotic, (176) 179 /!&actamase, (175) 267 Lactate dehydrogenase, (169) 97 (R)-Lactate dehydration, (171) 79 (R)-Lactate dehydrogenase (NAD), (171) 79 Lactation, (169) 12 Lactic acid, (165) 23 1 Lactoferrin, (168) 203 Lactogenic receptor, (166) 352 Lactoperoxidase, ( 174) 300 Lactose transport, (172) 33 Lactotransfertin, ( 176) 185 Laminin, (172) 17; (172) 29 Large subunit, (165) 43 Laser nephelometry, (168) 3 13 Lateraldiffusion, (169) 1; (174) 199 LDL, (170) 105; (173) 173 LDL internalization, (177) 76 Leader sequence, (177)41 Lectin,(165)97;(168) 197;(170)335;(171)277;(173)63;

(173) 80; (175) 59; (175) 249; (175) 325; (176) 120; (177) 99 Lectin homology, (175) 76 Lectin-cell surface interaction, (175) 82 Lens crystallin, (171) 297 Leukemia, (169) 194 Leukocyte, (178) 109 Leukotriene, (168) 23; (175) 289 Leukotriene B4, (166) 44 Leukotriene C,, (167) 109 Lewis negative (non)secretor, (174) 55 LexA repressor, (171) 207 Leydigcell,(178)73 Lif, (168) 54; (171) 179 Li+ cotransport, (168) 327 Li+ effect, (166) 258 Li+ electrode, (168) 327 Ligand binding, (169) 229; ( 178) 64 Ligand-receptor interaction, (178) 109 Ligandin, (177) 3 1 Light dependence, (176) 473 Light_harvestingcomplex,(165) 151;(170) 174;(171)47;

(175) 231 Light induction, (173) 3 1 Lignitication, (I 69) 7 L&tin degradation, (I 69) 247 Limited proteolysis, (172) 212 Limulus test, (167) 226; Lipase; (170) 375 Lipid, (177) 236; (178) 55 Lipid A, (167) 226 Lipid A analog, (167) 226 Lipid activation, (168) 271 Lipid bilayer, (174) 199 Lipid bilayer membrane, (176) 398 Lipid composition, ( 169) 169 Lipid hydroperoxide, (172) 231; (178) 47 Lipid intermediate, (168) 155 Lipid lateral distribution, (174) 1 Lipid microviscosity, (172) 103 Lipid order, (169) 169

58 Volumes 165-178 (1984)

Lipid peroxidation, (166) 232; (169) 169; (171) 320; (172) 245; (176)97;(178)47;(178) 119

Lipid phase behavior, (169) 256 Lipid-surface contact, (176) 398 Lipid synthesis, (177) 76 Lipid vesicle, (167) 277; (175) 5 1 Lipoamide dehydrogenase, (168) 265 Lipogenesis, (166) 151; (175) 8 Lipogenic substrate, (175) 8 Lipopolysaccharide, (170) 268; (176) 207 Lipoprotein, (166) 179; (171) 245; (173) 264 Lipoprotein lipase, (178) 132 Lipoprotein metabolism, (175) 159 Lipoprotein signal peptidase, (166) 179; (171) 245; (173) 264 Liposome,(168)43;(169)40;(170) 131;(173)80;(174)233;

(175) 178; (176) 351; (178) 20; (178) 109 Lipoteichoic acid, (166) 301 Lipoxygenase,(l68)23;(172)231;(173)251 Lipoxygenase product, (177) 255 Liver metabolism, (167) 199 Local anesthetic, (169) 229 Localised chemiosmosis, ( 172) 33 Localization, (166) 32 1 Low-angle laser-light scattering, (175) 419 Low-level chemiluninescence, (169) 63 Low oxygen affinity, (172) 155 Low-temperature guorescence, (168) 10 Low-temperature spectroscopy, (167) 186 Luminol sensitization, (178) 47 Luteinizing hormone, (169) 21; (176) 101 Luteinizing hormone-releasing hormone, (168) 208 Luteinizing hormone-releasing hormone inactivation, (176) 101 Lymphocyte, (170) 391; (171) 37; (173) 319; (175) 82; (176)431;

(177)99 Lymphocyte activation antigen, ( 17 I) 3 1 Lymphocyte stimulation, (178) 257 Lymphokine, (170) 391; (178) 257 Lymphotoxin, (178) 257 Lysine-ketoglutarate reductase, (17 1) 59 Lysine residue, (166) 352 Lysis, (166) 293 Lysis-lysogeny, (177) 115 Lysophosphatidic acid, (166) 115 Lysosomal degradation, (168) 134 Lysosomal inactivation, (167) 259 Lysosomal membrane, (168) 15; (177) 221 Lysozyme, (168) 331; (176) 307 Lytic enzyme, (166) 293

%-Macroglobulin, (177) 89; (177) 109 Macrophage, (175) 59; (177) 66 Magnetic chromatography, (170) 232 Magnetic microsphere, (170) 232 Magnetic orientation, (173) 403 Malaria, (173) 108 Malate dehydrogenase, (178) 15 Malate inhibition, (178) 199 Malignant hyperthermia, (167) 123 Malondialdehyde, (178) 119 Malonyl CoA, (176) 38 1 Manganese,(168)281;(176)341;(177)2;(178)51 Manganese signal, (176) 346

Mannose, (173) 63 Marine alga, (173) 41 Mass spectrometry, ( 170) 28 1 Mass spectrum analysis, (168) 235 Mating gamete, (166) 293 Mating pheromone, (166) 339 Matrix-bound poly(U), (178) 283 Matrix-coupled messenger, (165) 280 Medroxyprogesterone acetate, (170) 263 Meiosis, (167) 193; (177) 81 Melanotropic activity, (170) 315 a-Melanotropic hormone, (168) 208 a-Melanotropin, (170) 3 15 Melibiose, (173) 295 Membrane adaptation, (172) 33 1 Membrane antigen, (175) 279 Membrane asymmetry, (167) 18 1 Membranebound,(166)81;(167)142 Membrane-bound enzyme, (167) 42 Membrane-bound proteinase, (173) 199 Membranefluidity,(169) 169;(172) 103;(173)255 Membranefusion,(166)49;(166)223;(169)40;(173)80;

(174) 304; (178) 20 Membrane labeling, (168) 255 Membrane leakage, (169) 279 Membrane permeability, (166) 175 Membrane phosphorylation, (170) 55 Membranepotential,(165)67;(167) 176;(172)261;(174)211;

(174) 223; (175) 95; (177) 17; (178) 301 Membraneprotein,(166)223;(166)367;(168) 149;(168)231;

(172) 163; (172) 309; (174) 7;(174) 199 Membrane reconstitution, (169) 85 Membrane resistance, (175) 275 Membrane transport, (174) 71 Membrane vesicle, ( 166) 120; ( 175) 329 Meproadifen, (174) 267 2-Mercaptoacetate, (176) 334 3-Mercaptopyruvate, (176) 334 light Meromyosin, (168) 75 Meromyosin heavy chain, (168) 260 Met-enkephalin, (178) 39 Metenkephalin analog, (170) 229 f-Met-Leu-Phe, (176) 193 Metabolism,(169)261;(170)73;(172)279 Metabolite mediation, (169) 287 Metal cluster, (177) 2 Metal ion cofactor, (165) 251 Metal-thiolate cluster, (168) 174 Metalloporphyrin, (168) 70; (172) 267 Metalloprotein, (171) 215 Metallothionein, (168) 174 Metaphase chromosome, (165) 2 11 Metastasis, (172) 17 Methanogen, (176) 462 Methanol dehydrogenase, (168) 217 Methionyl-tRNA synthetase, (174) 20 Methyl relaxation. (172) 198 Methylammonium, (176) 453 dam Methylase, (176) 449 (2S,3S)-3-Methylaspartate, (171) 73 Methylatable substrate structure, (168) 166 Methylation, (165) 265; (173) 151

Volumes 165-178(1984)

Methylation analysis, (169) 194 5-Methylcytosine, (168) 302; (178) 59 4-Methylene glutamic acid, (177) 265 QMethylpyrazole, (172) 177 Methylthiouracil, (166) 71 Mg2+,(176) 161;(178)228 Mg? + activation, (167) 295 MgZ + ADP binding, (174) 11 free Mg2+, (167) 295 MgCI, dependence, (178) 10 Micro sequencing, (167) 59 Microbody, (169) 35 Microcirculation, (167) 117 Micrococcal nuclease, (171) 240 Mi~ofilament, (175) 393 Microinj~tion, (1’73) 151 Microsequencing, (176) 365 Microsomal membrane, (166) 3 14; (167) 42 Microsomal mixed function oxidase, (167) 131 Microsomal monooxygenase, (167) 13 1 Microsome, (175) 275 Microtubule,(l67) 151;(169)313;~172) 139;(178)264 Microtubule assay, (173) 67 Microtubule assembly, (174) 128 Microtubule-associated protein, (169) 313 Microtubule protein, (178) 264 Microvillar enzyme, (166) 28 Mild desorption, (177) 195 Mineralocortocoid, (178) 1 Minicircle, (168) 139 Minicircle cloning, (168) 139 Miscoding, (178) 6 Misreading, (178) 283 Mitochondria, (166) 141; (166) 367; (166) 393; (167) 10;

(167)241;(169)3~;(170) 131;(170) 181;(170) 186; (171)249;(173) 19;(173) ~4~(175)95;(176)381;(177)47; (177) 138; (177) 143;(177)231;(178)2~,(178)24~ (178) 306

Mitochondrial H+-ATPase, (166) 19 Mitochondrial enzyme, (165) 133; (178) 245 Mitochondrial fraction, (173) 119 Mitochondrial import, (177) 41 Mitochondrial intron mutant, (169) 73 Mit~hond~al &enzyme, (173) 367 Mit~hond~al membrane potential, (170) 181 Mitochondrial protein import, (178) 306 Mitochondrial protein transport, (178) 161 Mitochondrial respiration, (165) 145 Mitochondrial ribosome, (173) 277 Mitochondrial5 S rRNA, (169) 67 Mitogenic agent, (176) 43 I Mitogenic stimulation, (169) 189 Mitosis, (167) 193 Mn, (170) 350 Mn protein, (175) 429 Mn2+ activation,(l71) 173 Mn’ +-binding, (166) 381 MO-Fe-protein, (173) 394 Model membrane, (165) 79 Modified LDL, (171) 149 Modified-recognition site, (167) 147 Moenomycin, (168) 155

59

MoFe protein, (166) 39 Moiar relationship, (176) 129 Molecularcloning,(166) 179;(170) 125;(173)99,(177)23;

(177) 57 Molecularevolution,(l65)46; (171) 17 Molecular expansion, (168) 174 Molecular form, (168) 125 Molecular instability, (172) 155 Molecular length, (168) 75 Mo1ecu1armass,(170)81;(171)41 Molecular stalk, (169) 17 Molten-globule state, (165) 88 Molybdoprotein, (177) 260 Monensin,(l65) 133;(172)275;(175)63 Monoclonal antibody, (165) 111; (166) 326; (167) 15: (168) 302:

(168) 307; (170) 15; (171) 192; (172) 17; (i73)357; (l75)279; (178) 204

Monolayer tumor cell, (170) 277 Monomer structure, (178) 101 Monomeric hemoglobin, (178) 3 1 Monooxygenase, (175) 199 MonoQ chromatogmphy, (167) 155 Monosodium mate crystal, (167) 109 Monospecific antiserum, (172) 189 Monotreme erythrocyte, (167) 83 Monte Carlo study, (167) 245; (171) 325; (173) 347 Mosaic protonic coupling, (165) 1 Multichannel diffractometer, (165) 97 M~tienz~e complex, (168) 217; (178) 6 Multiple sclerosis, (I 77) 236 Muscarinicreceptor, (165) it8 Musclecontraction,(l73)403;(176) 144 Mutation, (173) 360 Mycoplasmamembrane,(l75) S1;(175) 189 Mycotoxin,(l75) 189 Myelin, (177) 236 Myelin basic protein, (168) 208; (169) 224 Myelin proteolipid complex, (172) 343 Myeloperoxidase, ( 174) 300; (178) 25 Myocardial metabolism, (167) 73 Myocardium, (171) 121 Myofibril, (167) 52; (174) 11 Myofibrillar protein, (176) 215 Myogiobin, (165) 4Q; (178) 165 Myosin, (168) 7; (168) 108; (168) 169; (176) 75; (178) 209 Myosin hinge, (176) 197 Myosin isoenzyme, (178) 209 Myosin isozyme, (166) 7 1 Myosin kinase, (165) 269 Myosin light-chain, (173) 124; (178) 209 Myosin light~~in kinase, (167) 215; (170) 383 Myosin light-chain modification, (172) 198 Myosin-linked regulation, (168) 260 Myosinrod,(l68)75;(176) 197 Myosin subfragment-2, (168) 75 Myxothiazol, (178) 336; (178) 343

N-terminai peptide, (167) 92 N-terminal proteolysis, (168) 29 N-terminal sequence, (176) 185 Nat, (173) 301 Na+ cycle, (165) 254

60 Volumes 165178 (1984)

Nitrogen-15 enrichment, (175) 259 Nitrogenase, (166) 39; (173) 394 Nitrosoureas, (176) 426 NMN(H), (176) 321 NMR, (165) 51; (165) 57; (169) 79; (170) 355; (173) 15; (173) 259;

(174)310;(175)364;(178)39;(178) 101 NMR assignment, (175) 364 NMR contrast agent, (168) 70 NMR imaging, (168) 70 NMR spectroscopy, (170) 99 ZD-NMR, (169) 107; (174) 243; (178) 123 ‘T-NMR, (178) 34 19F-NMR, (166) 373 ‘H-NMR, (165) 231; (166) 288; (167) 73; (168) 331; (170) 73;

(170) 343; (172) 198; (173) 342; (174) 15; (175) 259; (175) 317; (176) 307; (178) 123

=P-NMR, (168) 1; (169) 256; (171) 165; (171) 169; (174) 248; (176) 88; (176) 161; (176) 389; (176) 393; (177) 71; (178) 137

NOE, (165) 57; (165) 216; (175) 117; (176) 307; (176)449 NOE-distance constraint, (174) 243 NOESY, (169) 107 Non ideal helix, (176) 110 Non ionic surfactant, (167) 79 Non zinc alcohol dehydrogenase, (165) 190 Noncatalytic nucleotide-binding site, (174) 66 Noncomplementary pair, (167) 147 Nonenzymatic glucosylation, (176) 27 Nonenzymatic glycosylation, (170) 23 Nonhistone, (165) 211 Nonhistone protein, (172) 172 Nonshivering thermogenesis, (170) 18 1 Noradrenaline, (166) 393 Nuclear dinucleoside triphosphatase, (166) 57 Nuclear matrix, (171) 13 Nuclear membrane breakdown, (167) 193 Nuclear polyhedrosis virus, (167) 254 Nuclearprotein,(l68)49;(169) 165 n&Nuclear antibody, (169) 90 Nuclease, (165) 93 Nuclease digestion, (169) 309 Nucleicacid,(l72)43;(175) 159 Nucleic acid homology, (174) 208 Nucleophilic agent, (173) 179 Nucleoside diphosphate kinase, (178) 288 Nucleoside transport, (176) 444 Nucleosome, ( 169) 30 Nucleosome assembly, (175) 321 Nucleosome-Pt, (176) 389 5’-Nucleotidase,(l67)235;(171)215 Nucleotide base stacking, (167) 245; (171) 325; (173) 347 Nucleotide-binding protein, (175) 387 Nucleotidesequence,(l67)254;(167)263;(174)38;(176) 105;

(178) 105 Nucleotide specificity, (178) 69

Obese rat, (174) 86 Octadeca-9,1 I-dienoic acid, (171) 320 Dctylglucoside, (176) 125 n-Octyl+D-glucoside, (176) 34 1 2’,5’-Oligo(A), (171) 111 2’,5’-Oligo(A) synthetase, (166) 199 2’,5’-Oligoadenylate, (171) 101

Na+-dependent transport, (166) 357 Na+ effect, (166) 258 Na +-electrochemical potential, (176) 125 Na+ occupancy, (170) 191 Na+ pump, (176) 125 NaCleffect, (166) 13 NAD dependance, (168) 2 17 NAD kinase, (167) 332 NAD+,(l65)265 NAD+ kinase,(l75)419 NADH dehydrogenase, (168) 217 NADH oxidase, (176) 125 NAD(H), (176) 321 NADP binding study, (165) 255 NADP reduction, (166) 81 NADP-reduction catalysis, (166) 8 1 NAD(P)+ dependence, (177) 143 NAD(P)+-transhydrogenase, (177) 143 NADPH, (168) 38 NADPH-diaphorase, (170) 85 NADPH oxidase, (170) 157 NAD(P)H:quinone reductase, (169) 63 Na+/H” antiport, (165) 254; (176) 166 Na+/H+ countertransport, (172) 272 Naloxone, (177) 28 1 Native protein fragment, (170) 28 Natriuresis, (167) 352 NDP kinase, (178) 264 Negative staining, (170) 335; (173) 217 Nephron microdissection, (169) 138 Nerve cell, (177) 300 Nerve growth factor, (166) 104 Neuro-intermediate lobe, (175) 407 Neurofilament, (170) 81 Neurohypophysis, (175) 135 Neuromuscular junction, (170) 147 Neuronal acceptor, (174) 116 Neuropeptide, (173) 307 Neuropeptide Y, (177) 125; (177) 175 Neuropeptide Y receptor, (177) 125 Neurophysin, (177) 175 Neurotoxin, (174) 15 Neurotransmitter, (170) 49 Neurotransmitter release, (174) 116 Neurotransmitter transport, (171) 303 Neurotrophism, (166) 393 Neutrophil,(165) 171;(166)44;(166) 165;(168)23;(175) 170;

(178) 25 Neutrophil metabolism, (170) 157 NH&l, (177) 11 NH,Cl effect, (175) 433 N, protein, (176) 301 Nicotinamide mononucleoside, (176) 321 Nicotinic acetylcholine receptor, (174) 267; (178) 64 Nigericin, (165) 133; (172) 275 rH]-Nimodipine, (167) 88 Nitrate reductase, (176) 453; (177) 260 Nitrendipine receptor, (172) 114 Nitrification, (170) 33 1 Nitrobenzylthioinosine, (176) 444 Nitrobcnzylthioinosine covalent binding, (176) 444 Nitrogen metabolism, (178) 123

Volumes 165-178 (1984)

Oligomycin sensitivity-conferring protein, (166) 19; (175) 109 Oligonucleotideprobe,(l75) 159;(176)37 2’,5’-Oligoriboadenylate, (166) 311 Oligosaccharide structure, (169) 194 Oncogene,(l69) 147; (177) 151 Oncogene product, (175) 387 Oncogene product pm=, (177) 15 1 Oncogenic transformation, (170) 125 Operator,(175) 317 atpA Operon, (177) 274 ileS-1spA Operon, (17 1) 245 ileS-1spA Operon, (173) 264 Nar Operon, (177) 260 Ophthalmology, (171) 297 Opiate receptor, (177) 281 Opioid receptor, (170) 378 Opsin shift, (166) 245 Order parameter, (172) 103 Ori site, (167) 254 Omithine decarboxylase, (174) 275; (175) 131 Omithine transcarbamylase, (167) 259 Omithine translocator, (170) 13 1 Omithine uptake, (170) 131 Orosomucoid, (168) 79 Oscillation, (172) 235 Osmoelectric molecular rotation, (176) 287 Osmolarity, (168) 43 Osteoblast differentiation, (173) 48 Osteocalcin, (165) 16; (173) 169 Osteogenic sarcoma antigen, (17 1) 3 1 Ouabain-binding site, (176) 467 Outer membrane, (166) 175; (170) 268; (173) 85 Ovine chorionic somatomammotropin, (166) 352 Oxaloacetate transport, (178) 15 Oxidase, (169) 247 Oxidation state, (174) 219 /?-Oxidation, (166) 141 Oxidative phosphorylation, (176) 79; (177) 231 2-Oxo-carboxylic acid reductase, (167) 25 2-Oxoacid dehydrogenase complex, (172) 38 Oxothiazolidine carboxylate, (178) 27 1 Oxygen ahinity, (166) 8 Oxygen consumption, (167) 117 Oxygen-derived free radical, (176) 155 Oxygen dissociation curve, (171) 187 Oxygenevolution,(l65) 163;(166)381;(167) 127;(168) 113;.

(168) 118; (168) 281; (170) 89; (170) 169; (170) 350; (171) 173; (173) 36; (173)41; (174) 157; (175)429; (176) 341; (177) 2; (177) 269; (178) 51

Oxygen-evolving complex, (175) 255 Oxygen evolving-complex mechanism, (177) 2 Oxygen lability, (167) 137 Oxygen partial pressure, (177) 6 1 Oxygen radical, (166) 232; (178) 25 Oxygen reduction, (166) 362 Oxygen toxicity, (170) 162 Oxygen uptake, (175) 95 Oxytocin biosynthesis, (174) 262 Oxytocin precursor, (174) 262 Ozone, (176) 155

61

P700, (173) 209

31P assignment, (176) 393 Packing arrangement, (168) 97 Palindrome, (173) 233 Palmityltransferase, (176) 381 Palytoxin,(l73) 196;(178)44 Pancreaticacini,(l70)64,(171) 183 Pancreaticislet,(l70)247;(175)21 Pancreatic ribonuclease, (171)253 Pancreatic secretory factor, (166) 273; (166) 283; (172) 284 Papain, (175) 299 Paramagnetic reagent, (168) 70 Parametrial white adipose tissue, (167) 10 Parasitic protozoa, (176) 55 Parathyroid hormone, (169) 49; (176) 220 Parathyroid hormone release, (175) 72 Parotid membrane, (178) 278 Partial trypsin digestion, (166) 109 Particulate phosphofructokinase, (175) 294 Partitioning, (168) 89 Patch clamp, (178) 20 PW+,(l72)250 Penicillin-binding protein, (165) 185; (168) 93; (168) 155;

(176) 179 Peptideconformation, (165) 51; (165) 57 Peptide-DNA complex, (169) 205 Peptide elongation factor 1, (177) 112 Peptide HI, (174) 258; (175) 307 Peptide HI precursor, (174) 258 Peptide hormone, (177) 104 Peptide isolation, (166) 267; (170) 28; ( 172) 142 Peptide mapping, (17 1) 249; ( 175) 439 Peptide precursor, (168) 293 Peptide purification, (167) 352 Peptidesequence,(l72)142;(178)64 Peptide structure, (I 75) 140 Peptide synthesis, (178) 275 Peptidoglycan, (176) 179 Peptidoglycan crosslinking, (168) 155 Peptidoglycan synthesis, (168) 155 Peptidyl aldehyde, (167) 273 Peptidyl transferase., (166) 53 Peripheral membrane protein, (168) 121 Periplasmic protein, (170) 165 Permeability, (170) 268 Permeability coefficient, (172) 103 Peroxidase, (171) 309 Peroxide, (177) 6 Pertussis toxin, (172) 95; (175) 25; (176) 301 pH-dependent transition, (173) 85 pH gradient, (176) 133 pH homeostasis, (165) 254 pH jump, (165) 254 pH measurement, (170) 186 pH regulation, (173) 295 pH titration, (174) 15 cytoplasmic pH, (165) 254 internal pH, (166) 120 intracellularpH, (165) 231;(171) 165; (172) 275; (174) 248;

(176) 161 cytosolic/mitochondrial pH gradient, (177) 138 Phage 1, (165) 238 Phagocytosis, (167) 79

62 Volumes W-178 (1984)

~sp&Qry~~on activator, (172) 38 ~ospharyfar~ (1X> f fS Phospho~lationsite,fl7l)21I;(174) EIZ$(l%] 169 Phaspbarylcholine, (176) 88 Phosphorylethanolamine, ( 178) 137 Phusphaserine, (175) 5S 3-Fhoghoshikimate I-carboxy~nyltransferase, [I65) 121 P~s~~~~~on~, jIT5) SS Pbo~ph~~f~, (I631 319 Fhos~~~~nsferase active site, (i 78) 288 Phosphotransferasepurification, (169) 319 Phosphotransferase system, (170) 55 PhotaaIEnity label, (169) I I2 Photo&nit-y labeling, (166) 109, (166) 146; (167) 327: (174) @

~oto~ea~~g, fi74) 199 Photo&mot herapy, {I 72) 267 Photocrosslinking, (163) I6R fI74) 1 Photocycle, (178) 33 1 Photalysis study, (166) 245 Photophosphorylation, (165) 145;(174) 248 Phot~pr~~~ (I@ 245 Photons EWA derivatives fi7fi) 290 Phot~~for,~l~~ IZl~(I72~9I~~I~6~4~3 Photoreceptor membrane, (i69) 256 Pbotcrsensitizer, (172) 267 Photosynthesis,(l65) IO7;(X65) 145;(165) 1X$(165) 163;

PhotosyntheticapparatW, (171) 267 Photosynthetic bacteria, (I 75) 23 1 Photosynthetic water axidation, (174) 157 PhotcrsystemI,(Mi) MO; (168) 10;(170) 17a;(171)47;(172)239;

(17;2)255;(173)209;(17~~24 Phososystem IJ, f165) fS6; (167f127; (163 316; (167) 32521;

Photosystem II complex, (165) 151 PhotctFystem II particle, (M6) 381; (168) 281; (176) 346 Phylogeny, (167) 263; (168) 307; (172) 75; (176) 105 ~~~o~a~~ti~i~~ {IT%] 297 Pj car&r> (f65) g3 Pi ef%ct, (175)433 pT change, (172) 25 Picorn~virus, (170) 339 Picrotoxin, (175) 193 Pigment protein, (168) 10 P~~ent-~o~~~mp~x~ (171) 47 Elin, (173) 103 PilocqMe, (167) 339 Pituitary, (178) 83 Pituitary culture, (176) X01 PK 1 t 195, (173) 255 PK II 195 binding, (169) 1% P&mar membras (176) 385 Plant plasma menbrsne vesi&e, (1%) 27i Plasma factor, (171) 280 Plasma fibronectin, (I 73) 283 Plasma inhibitor, (176) 223

Pballo~din, ff67) 241; (175) 393 Phalloto~n~ f176)44I Pharmacology, (I75) 307 Phase fluorimetry, (165) 107 Phase partitioning, (168) 113 Phase transition, (168) 43 Phase transitiou temperature, (171) Ml Pheno~i~ne~ { f 6S) 269 P~enot~~~l6~~ IO3 ~-P~nylisopro~yIadenos~n~ (167) 1; (17% 68 8-Phenyltheophylline, (167) I Pheophytin, (165) S 56 c@ Pheromone, (I 66) 339 Phorbolester, (166) 165; (170) 38; (X70) 6&jI70) 15% (1%) 37;

Phosphatase, (167) 235; (I69) 251; (170) 33; (ITO] 365; (I%) 253 Phosphatase reaction, (175) 303 Phosphateeffect, (170) 121 Phosphate starvation, (166) 301 Phosphate translocator. (168) 255 respite transport, f176) 220 ~~-Ph~p~tid~te pho~hoh~ro~~~ (1%) 2g4 Phosphatidyl~bol~~~ (168) 278; (170) I; (178) 55 Phosphatidylinasitol, (167) 15f; (176) IS1 Phosphatidylinositol metabolism, (X71) 179 Phosphocreatine, (165) 23 1 Phosphodiesteri, (165) 269; (166) 311; (167) 142; (173) 385;

P~o~h~~~ter~~ i~h~~tor~ f172) 167 ~-Phosph~i~te~~, (f 76) 65 2’-Phosphodiesterase-protein inhibitor, (176) 65 Phosphoenolpyruvate, (165) 117: (I 70) 55 Phosphoenolpyruvate carboxylase, (1%) 199 Phosphofructokinase,(l69) 12;(16~)287;(175)294;(17S)369 Phosphofructokjn~2, {t 76) 484 ~o~hofr~toki~~ gene product, (I75) 294 Pho~hofru~tokin~ mutant, (lirfrf 294 6-Phosphofructo-2-kinase, (172) 51; (t78) 253 Phosphoinositide, (I 77) 36 Phosphoinositide breakdown, (178) 278 Phosphoinositide system, (17.3) 113 Phosphotipase, (167) 42 Ph~ph~ipa~ AZ, (X6@ 43; ft72j 284; (f72f 51; ffXj93 PhosphoIjpase C, (1’30) 43; ( t7Oj 247; (I 76) 93 Phospholipid,(I~)301;~1?1~ 169:(174) 1;(177)36 Phospholipid bilayer, (167) 69 Phospholipid response, (168) 54 Phospholipid synthesis, (178) t 37 Phosphomonoester, (178) 137 Pho~ho~ot~~~~ (165) f 17; f17D) fS Phosphomm~do~, (175) 124 Phosphorescenie lifetime, (1 T?) 287 Phosphoribosyl pyrophosphate madulafion, (f70J 277 Phosphoryl transfer. (173) 179 Phosphorylaa a. (168) 38 Phosphorylase a, (I 69) 45 Pho~h~ryl~ kin&se, (167) 291; (167) 295; (I76r) 421 Ph~ho~Iatable peptide- [f7Tff 211 Phosphoryl~t~~n, (165) 117; (169) 127; (169) 323; (1705 3ff);

(170)360;(171)293;(172)87;(176) 1I5;(1?6)4?3:(176)479; (177) 151

Volumes 165-178 (1984)

PIasma membrane, (166) $65; (168) 241; (169) 169; (172) 163; 1175)383;(175)422;(178)83

Plasma membrane protein, (165) 83 Plasma protein, (166) 67; (170) 370; (177) 129 Plasmalemma, (167) 181 Plasmid,(l67)254;(175)377 Plasminogen, (171) 131; (172) 29 Plasminogen activator, (168) 33; (171) 131; ($72) 29; (177) 66 Plastic adhesion, ($68) 241 Plastoquinone, (165) 156; (169) 1 Platelet, (165) 26; (173) 164 Platelet-activating factor, (166) 13; (170) 1; (176) 93 Plateletactivation,(l70)43;(l7l)89;(172)2?2 Platelet adhesion, (172) 167 Plat~eta~e~tjon, (166) tl5; (172) 167 Platelet membrane, (l65) 290 Podophyilotoxin, (168) 278 Point mutation, (169) 147 Polar head specificity, (167) 69 Polarized UV micraphotometry, (176) 441 Poloxamer, (167) 79 Poty(A)* mR??A, (171) 25 Poiy(A)+ RNA,(M) 161 PoIyadenylation, (I 71) 25 Poly(ADP-ribose)synthetase, (168) 275 Polyamine, (171) 221; (174) 275 Polycation, (166) 175 Poly[d(G-C)], (173) 243 Polyene antibiotic, (178) l27 Polyethyl~e glycol, (178) 275 Poly[ethyIene glycol), (l66) 49 Polyglutamic acid, (167) 170 Polylysine, (166) 175; (166) 335; (175) 321; (l76)27 Polymerization, (170) 94 Polymorphism, (170) 254 Pol~~~some, (170) 19 Polypeptide9 (167) 127; (170) 169; (177) 95 Polypeptide chain ~nfo~~tion, (166) 33 Polypeptide composition, (170) 105 Polypeptide conformation, (174) 15 Polypeptide precursor, (168) 255 10 kDa Polypeptide, (175) 255 24 kDa Po$peptide, (KS) 118 33 kDa Pofypeptide, (170) 350 Pol~h~phoinosi~e, (173) 389; (176) 235 Polyprotein processing, (170) 339 Polyribosome, (176) 261; (176) 401 Polysome, (168) 65 Polytene chromosome, (173) 147 Pore-forming protein, ft69) 85 Poresize+(l71) 160 Porin, (166)4% (169) 85 Porous polymer membrane, (175) 13 Porphyria, (173) 142 Positron emission tomograph, (177) 281 Postnatal development, (170) 147; (172) 25 Posttranslational modification, (165) 102; (168) 287; (173) 113 P~t~ns~tional processing* (l68) 293 Pot~~c~n~de, (16%) 1 Prealbumin, (l74) 162 Precursor, (166) 104 Precursor protein, (170) 165; (178) 161; (178) 306

63

Pregnancy urine, (t72) QQ Pregnenolone, (167) 103 Prekeratin, (178) 92 Preparative isoelectric focusing, (168) 79 Preprocalcitonin, (167) 92 Pribnow box, (172) 64 Primary acceptor, (173) 9 Primary donor, (273) 9 Primary reaction, (f65) 107 Primary structure, (173) 360; (176) 2E Primer extension, (173) 247 Proapolipoprotein A-I, (170) 109 Processing, (166) 28; (172) 303 Processingprotease,(l%) 161 Processing site, (167) 249 Procion red, (l68) 79 Proenkephalin, (172) 212 Profilactin, (173) 399 Profilin, (173) 399 Proform biosynthesis, (175) 63 Progesterone, (175) 25 Prohormone, (172) 303; (175) 439 Prohormone processing enzyme, (175) 135 Proinsulin, (168) 299 Prolactin, (166) 18% (166) 352; (177) 71 Prolactin fragment, (171) 192 Prolactinvariant, (171) 192 Proliferation,(166)136;(170) 139 Proline, (174) I5 Proline cotransport, (168) 327 Promoter, (166) 307 ‘-35’ Promoter region, (172)64 Pronatriodilatin, (172) 80 Propeptide, (167) 352 Propionate CoA-transferase, (171) 79 Prorenin, (175) 439 Frost~n, (176) 202 Prosta~iandin, (M6)44; (f66) 136; (169) 49; (172) 27% (174) 143 Prostaglandin E, (169) 203 Prostaglandin E,, (165) 290; (173) 291 Prostaglandin E analog, (169) 203 Prostaglandin &-Q-oxoreductase, (171) 141 Prostaglandin H synthase, (165) 233 P~sta~a~n secretion, (I 76) 202 Prosthetic group, (165) 293; (170) 305 Protease,(165)111;(170)33 Protease activation, (175) 219 Protease gene, (178) 79 Protease inhibitor, (166) NJ; (175) 343 Protein A-Sepharose, (174) 300 Protein A24 lyase? ( f 76) 426 Protein A24 (uHZA), (176) 426 Protein biosynthesis, (172) 163 Protein biosynthesis regulation, (176) 26E Protein composition, (167) 98 Protein crystal, (165) 63; (165) 97; (170) 143; (177) 277 Protein crystallography, ( I74) 96 Protein degradation, (166) 253 ~teindena~ra~on, (i68) 331 Protein-DNA complex, (173) 351 Protein dynamics, (169) 147 Protein evolution, (171) 131; (175) 208

64 Volumes 165-178 (1984)

Proteoliposome, (165) 151 Proteolysis, (165) 255; (166) 13; (166) 223; (168) 134; (170) 105;

(170)259;(172)29;(176)211;(176)215 Proteolysis product, (170) 143 Proteolytic digestion, (168) 23 1 Proteolyticenzyme, (168) 33; (173) 222; (175) 343 Proteolyticfragment,(171) 37 Proteolytic processing, (175) 63 Proteolytic system, (166) 253 Prothrombin, (171) 131; (173) 169 Protochlorophyll proteincomplex, (167) 186 Proton antiport, (173) 1 Proton conductance, (170) 186 Proton conductivity, (172) 103; (176) 79 Proton-coupled reduction, (167) 339 Proton gradient, (167) 23 1 Proton permeability, (167) 231 Proton pump, (175) 422; (178) 33 1 Proton release pattern, (176) 83 Proton translocation, (178) 187 Proton transport, (168) 15 Proton/deuterium exchange, (170) 355 Protonmotive force, (172) 33; (176) 79 Protoplast, (169) 40 Protoplast fusion, (173) 331 Protozoa, (169) 305 cis-PtCla(NH,&, (176) 393 PutTinduction, (173) 147 Purification, (174) 233 Purine, (170) 277 Purine nucleoside phosphorylase deficiency, (165) 207 Purinergic receptor, (172) 335 Puromycin, (168) 134 Purple bacteria, (165) 107 Pyranine, (166) 120 Pyrenyl actin, (173) 399 Pyridine nucleotide, (173) 204 Pyridoxal S-phosphate, (170) 223 Pyridoxal5’-phosphate enzyme, (174) 76 Pyrimidine antimetabolite, (170) 277 Pyrimidine dimer excision, (168) 245 Pyrimidine salvage, (176) 55 Pyrimidine synthesis, (176) 55 Pyrogenicity, (167) 226 Pyrophosphate-D-fructose&-phosphate 1-phosphotransferase,

(169) 287 Pyrophosphate-phosphotransferase, (175) 369 Pyrrolnitrin, (173) 5 Pyrroloquinoline quinone, (168) 217; (170) 305 Pyruvate, (175) 68 Pyruvatecarboxylase,(175)45;(177) 157 Pyruvate dehydrogenase activation, (176) 411 Pyruvate dehydrogenase complex, ( 176) 115 Pyruvate dehydrogenase. kinase, (176) 115 Pyruvate kinase, (171) 293

Qcycle,(172)261;(175) 100;(175) 105 Quantitative determination, (176) 360 Quatemary oscillation, (176) 83 Quiescent cell, (169) 185 Quin-2, (166) 44, (167) 19; (169) 189; (170) 196; (176) 151 Quinone analog, (172) 255

Protein export, (172) 183 Protein folding, (165) 88; (168) 331; (171) 131 Protein homology, (165) 190; (166) 19; (167) 301; (168) 97;

(169) 143; (175) 359 Protein interacting lipid, (172) 343 Protein isolation, (170) 105 Proteinkinase,(165) 117;(166) 170;(167) 193;(167)203;

(168) 108;(169)224;(170)33;(171)67;(171) 183;(171)211; (172) 139;(173) 179;(174) 132;(175)219;(176)65;(176)229; (176)235;(176)317;(177)36;(178)73;(178)253

Protein kinaseC,(166) 125;(170)38;(170)64;(170)247; (173) 389; (175) 170;(177) 151

Protein L7, (178) 101 Protein L16, (166) 53 Protein L30, (169) 107 Protein-nucleic acid interaction, (17 1) 207 Protein phosphatase., (167) 291 Protein phosphatase-1, (169) 45 Protein phosphatase ZB, (165) 269 Protein phosphorylation, (165) 255; (166) 96; (166) 125;

(166)233;(169)267;(170)49;(170) 139;(171)211;(171)289; (173)124;(173)337;(174)112;(176)133;(176)401; (178) 143

Protein processing, (168) 29 Protein-protein interaction, (168) 121; (172) 109 Protein purification, (177) 3 1; (177) 236 Protein recovery, (167) 59 Protein regulation, (166) 248 Protein secondary structure, (175) 227 Proteinsecretion,(171)245;(173)264;(177) 129 Protein sensor, (175) 299 Protein structure, (168) 97; (171) 297; (174) 228; (175) 317;

(177) 236; (178) 291 Protein structure prediction, (175) 387 Protein sulfation, (177) 129 Proteinsynthesis,(166)248;(168)65;(169)67;(171)9;(171)111;

(172)299;(173) 113;(173)277;(174)61;(175) 16;(178) 149; (178) 315

Protein-synthesis inhibition, (171) 277 Protein synthesis inhibitor, (171) 63 Protein synthesis initiation, (174) 47 Protein synthesis regulation, (176) 406, (177) 163 Protein S8, (173) 90 Protein S21, (173) 155 Protein4.1, (169) 161 9 kDa Protein, (170) 135 15 kDa Protein, (170) 135 16 kDa Protein, (177) 269 17 kDa Protein, (173) 36; (176) 341 23 kDa Protein, (168) 113; (176) 341; (177) 269 33kDaProtein,(166)381;(168)281;(175)429;(177)269 34 kDa Protein, (I 76) 341 48 kDa Protein, (176) 473 90 kDa Protein, (174) 80 32000 M, Protein, (166) 141 50 S subunit Protein, (167) 59 30 kDa Protein mRNA, (173) 247 SlOOProtein,(166)258 Proteinase, (173) 199 Proteinaseinhibitor, (168) 227; (170) 370; (177) 179 Proteinase K, (166) 155 Proteoglycan, (167) 343; (173) 75; (176) 37

Volumes 165178 (1984)

Quinone pool, (178) 343 Quinone redox cycling, (169) 63 Quinoprotein, (170) 305 Quinoxaline antibiotic, (176) 414

Racemisation, (171) 73 Radiation inactivation, (170) 89; (175) 383 Radioactive sugar analog, (170) 295 Radiochemical sequence analysis, (170) 339 Radioiodinated ligand, (176) 436 Radioligand binding, (167) 88 y-Radiolysis, (173) 27 Radionuclide imaging, (166) 202 Raman spectroscopy, (165) 223; (165) 227; (170) 331 86Rb transport, (176) 467 Reactioncenter, (165) 107; (166) 160; (167) 316; (178) 343 Reaction center P-840, (168) 149 Reaction center subunit, (166) 155 Reaction center triplet, (177) 277 Reaction mechanism, (177) 255 Reactive dye, (174) 162 Reactive oxygen species, (169) 63 Receptor affinity, (172) 95 Receptor binding, (169) 21; (172) 183 Receptor heterogeneity, (175) 279 Receptor solubilization, (170) 378; (172) 335 Receptor subunit, (172) 87 Recognition site, (168) 166; (176) 449 Recombinant plasmid, (169) 17 Recombination, (177) 81 Reconstitution, (165) 151; (166) 381; (166) 389; (167) 137;

(167) 277; (169) 67; (170) 131;(171) 5; (172) 255; (173) 36; (174) 233; (176) 125; (176) 341; (176) 351; (176) 385

Recovery metabolism, (171) 165 Redoxcenter topography, (172) 261; (175) 100 Redox equivalent recombination, (169) 219 Redox protein, (172) 11 Redox state, (173) 15 Redox titration, (175) 105 Reduced equivalent, (166) 141 Regeneration, (175) 131 Regulation, (177) 157 Regulatory phosphorylation, (167) 203 Regulatory subunit mutant, (175) 294 Release factor, (175) 90 Renaturation, (178) 114 Renin, (166) 104; (167) 273; (174) 102; (175) 439 Repeated site, (167) 147 Replication origin, (171) 13 cro Repressor, (175) 317 lac Repressor headpiece, (174) 243 Reserve globulin, (178) 193 Reserve prolamin, (178) 193 Resonance Raman spectroscopy, (174) 219; (178) 31 Respiration, (173) 142 Respiratory chain, (167) 176; (172) 261; (174) 167; (175) 100,

(175) 105 Respiratory membrane, (174) 167 Restricted proteolysis, (173) 357 Restriction endonuclease, (173) 99 Restriction enzyme, (178) 69 Restriction mapping, (170) 125

Reticulocyte lipoxygenase, (177) 255 Reticuloendothelial system, (167) 79 Retinal isomerization, (175) 337 Retinal location pH indicator, (178) 331 Retinal phospholipid, (170) 1 Retinal rod, (178) 228 Retinoic a&d, (168) 222 Retrovirus, (169) 194 Retrovirus genome, (178) 79 Reverse.-phase HPLC, (166) 8; (168) 125; (176) 223 Reverse transcription, (165) 285 Reversible chemical crosslinking, (171) 267 Rhesus polypeptide, (174) 7 Rhodamine, (165) 67 Rhodamine 6G, (178) 161 Rhodopsin, (168) 121; (175) 87; (176) 473 Rhythm, (171) 67 RIA, (167) 10; (167) 109; (168) 235; (169) 199, (173) 307 Riboflavin carrier ptotein, (178) 87 Ribonuclease,(l68)61;(171)25;(177)246 iRibonucleoprotein, ( 175) 16 mRibonucleoprotein. (175) 16 Ribosomalpr~tein,(i65)43;(167)59;(169) 107;(170)290,

(175) 213 Rib&&l protein gene, (175) 37 1 Ribosomal protein L2, (177) 189 Ribosomal protein L7/Ll2, (176) 32 Ribosomal protein L14, (169) 267 Ribosomalprotein S6, (169) 267; (175) 219 Ribosomal50 S subparticle, (171) 202 30 S Ribosomal subunit, (173) 90 Ribosome, (165) 280; (166) 194; (169) 17; (170) 290; (173) 337;

(175)90, (175) 203 Ribosome activation, (173) 155 Ribosome-associated phosphoprotein, (169) 267 Ribosome-binding sequence, (17 1) 197 Ribosome trypsinolysis, (176) 32 50 S Ribosome, (169) 67 Ribulose bisphosphate, (170) 355 Ribulosebisphosphate carboxylase, (173) 3 1 Ribulosebisphosphate carboxylase/oxygenase, (170) 355 Right shift, (171) 187 RNA 5, (174) 38 RNA-binding activity, (176) 406 RNA-binding protein, (170) 33 RNA blot hybridization, (172) 59 RNA catabolism, (166) 57 RNA ligase, (165) 93 RNA polymerase, (165) 31; (165) 72; (171) 240 RNA polymerase A, (173) 129 RNA processing, (169) 17 RNA-protein interaction, (166) 194 RNA recycling, (166) 57 RNAsequence,(l75) 183 RNA structure, (176) 255 RNA synthesis, (168) 61; (174) 61 RNA tumor virus, (174) 208 RNA virus, (177) 163 5 S RNA fragment, (173) 342 5 S RNA fragment-125 complex, (175) 259 small RNA, (171) 5; (177) 241 template RNA, (165) 72

66 Volumes 165-178(1984)

Secondary quinoneacceptor, (165) 163 S~onda~st~tu~,(165)22~(167)221;(171)1~(i77)205 Secondary structurecomparison, (168)97 Secondary structure prediction, (175) 267 Secretin,(166) 273; (166) 277; (166) 283; (172) 5.5 Secretin/vasoactive intestinal peptide family, (I 78) 233 Secretion,(i71) 183;(174)~,(176) 139 Secretory component, (168) 203 Secretory granule, (172) 212 Secretory immunoglobulm, (168) 203 Secretory vesicle, (175) 135 Seed, (178) 193 Seed protein, (175) 359 Self assembly, (173) 185 Semimembranous, (177) 5 1 Seminal piasma, (165) 11; (176) 21 Seminal plasmin, (172) 21 ~~q~none-iron complex, (17.5) 243 Semiquinone radical, (167) 37 Semisynthetic enzyme, (171) 253 Sendai virus, (174) 304 Senescence, (173) 251 Sensory control, (176) 1 Sequence, (166) 347 Ssquenceanalysis,(175)159;(175)183;f175)371;(178)233 Sequencewmparison,(169)241;(i75)213;(175)231;(178)79 Sequence homology, (166) 39; (167) 249; (169) 57; (171) 257;

(175) 109 Seqnencespecificity, (176)414 Sequential analysis, (165) 46 Sequentid immunoprecipitation, (175) 279 Serotonin-S, receptor, (171) 289 SERS spectroscopy, (173) 95 Serum-free culture, (166) 136 Sex hormone, (168) 307 Sex pheromone, (178) 97 Sex-specificity, (178) 217 Sexual dimorphism, (175) 129 Sexual reproduction, (174) 132 SH, tbiol, (176) 75 &-Sheet, (169) 107; (170) 229; (176) 355 Shift reagent, (178) 39 Sbikimate pathway, (165) 121; (170) 59 Short-chain collagen, (169) 179 Siaiic acid, (i72) 25 Sialic acid deficiency, (17 1) 285 Si~o~ywprot~n, (170) 29s SiaIyltr~sfera~, (170) 295 Sidedness, (171)271 Siderophore, (173) 53 Signal peptidase, (171) 245 Si~al~ptide,(l~) 179;(166)314 SignaJ recognition particle, (166) 314 Signal sequence, (165) 79; (171) 197 Signal sequence resemblance, (170) 28 Signai transdu&on, (175) 113 Signalling, (174) 132 Silk gland, (171) 127 S~n~~hanneJ current, (174) 267 Single crystal spectroscopy, (174) 219 Single group rotation theory, (172) 1 Single occupancy, (170) 191

3’.end 16 S RNA, (173) 155 hn RNA processing, (171) 25 hn RNA splicing, ( 17 1) 25 mRNA, (i67)92; (174) 238 mRNA activity, (174) 86 mRNA secondary structure, (165) 72 mRNA tr~slatio~, (178) 257 ar-Antitrypsin mRNA, (168) 84 hepatic mRNA, (170) 114 histone mRNA. (168) 65 rRNA,(166)307;(173) 129;(177)61 rRNA synthesis, (172) 21 5SrRNA,(171)17;(173)277;(17.5)183 16SrRNA,~l73~~ 18SrRNA,(167)249;(167)263 4.55 rRNA, (176) iOS eukaryotic rRNA, (167) 263 eukaryotic 5S rRNA, (176) 255 hybrid 5 S rRNA, (169) 17 tRNA binding, (165) 280 tRNA-binding site, (170) 290 tRNA fragment, (165) 93 tRNA-like structure, (176) 295 tRNA modification, (178) 6 tRNA-ribosome interaction, (J66) 53 tRNA sequence, (176) 462 Aminoacyl-tRNA synthetase, (176) 295 phosphoseryl tRNA, (169) 3 19 serine tRNA,(169) 319 suppressor serine tRNA, (169) 319 tRNA”‘“, (165) 285 tRNApbe, (165) 93 tRNAArs gene, (167) 165 seryi-tRNA:ATP phosphotransfe~~, (169) 3 19 RNase, (175) 356 RNaseI,(i71)202 cl-RNP,(177) 241 snRNP, (171) 25 Ro U-1788, (173) 255 Rod outer segment membrane, (172) 321 Rotational diffusion, (175) 329

YS labeling, (174) 24 S state, (176) 83 S-state deactivation, (165) 163 S, state reconstitution, (176) 346 Si mapping, (172) 64 S I-nuclease mapping, (173) 247 Sl protection, (167) 249 aBar&, (171) 63 Saturation transfer, (168) 33 1 SauJA, (173) 99 Scatchard analysis, (I 67) 277 Scattered gene arrangement, (167) 165 Schistosomiasis, (168) 235 Scurvy, (168) 287 SDS-gel el~tropho~~s, (169) 313; (172) 189 SDS micelle, (I 78) 39 SDS-PAGE, (i7i)4l;(i7i) 192 Second messenger, (168) 54; (175) 113 Secondary acceptor, (i 73) 9 Secondary donor, (173) 9

Volumes 165-178 (1984)

Single-strand specific nuclease, (176) 255 Singlet oxygen, (177) 295 Sinusoidal cell, (173) 63 Site Aanking, (167) 147 Site mapping, (178) 204 Site-specific cleavage, (172) 23 1 Site-specific endonuclease, (177) 23; (177) 57 Slime mould, (176) 245 Slow reacting substance of anaphylaxis, (175) 289 Smooth muscle, (170) 383 Smoothmuscle myosin, (176) 197 Snake venom, (178) 114 Sodium-bicarbonate symport, (176) 166 Solid phase, (173) 2 13 Solid-phase biosynthesis, (167) 47 Solid-phase peptide synthesis, (178) 233 Solid state, (170) 229 Solubilization, (166) 389; (167) 277 Solubilized receptor, (170) 243 Solution structure, (175) 117 Somatostatin, (166) 189; (169) 133; (177) 175 Somatostatin-141, (175) 21 Somatostatin-28 II, (175) 21 Somatotropic receptor, (166) 352 Sorting sequence, (178) 193 SOS response, ( 17 1) 207 Soybean inhibitor (Ku&z), (167) 210 Specialized myocardial tissue, (178) 209 Species difference, (168) 125 Specific binding, ( 175) 3 17 Specific-binding protein, (173) 319 Spectrin, (169) 161; (169) 323; (172) 109 Spectroscopic titration, (173) 85 Spectroscopy, (167) 137 Spermatogenesis, (177) 8 1 Spermidine/spermine I@-acetyltransferase, (178) 297 Spermine, (173) 331; (175) 321 Sphingomyelin degradation, (173) 159 Spin label, (169) 279; (172) 6; (173) 259; (173) 283 Spin trapping, (177) 295 Spinning cup protein sequencer, (174) 228 PHI-Spiperone binding, (166) 389 Stabilizing factor, (170) 135 Stacked associate, (167) 245; (171) 325; (173) 347 Stacking interaction, (169) 205 Starvation, (176) 115 State transition, (169) 229 Stellacyanin, (171) 257 Stereochemical configuration, (173) 95 Stereochemistry, (174) 275 Stereoselectivity, (173) 287 Stereospecificity, (177) 281 Steric hindrance, (166) 245 Steroid antagonist, (178) 1 Steroid hormone, (170) 114 Steroid 21-hydroxylase, (167) 131 Steroidogenesis, (172) 177 Stimulus-secretion coupling, (166) 283 Stoichiometry, (172) 33 Stokes radius, (168) 174 Storage globulin polypeptide, (166) 3 14 Structural analysis, (172) 155

67

Structural comparison, (176) 21 Structural model, (172) 1 Structural relationship, (175) 109 Structural similarity, (171) 85 Structural variation, (176) 110 Structure-function relationship, (173) 367 Styryl pyridiniumdye, (170) 181 Subcellular distribution, (170) 147 Submitochondrial particle, (176) 97 5-Substituted 2’-deoxyuridine analog, (173) 227 Substrate activation, (165) 25 1 Substrate analog, (167) 64 Substrate oxidation, (169) 261 Substrate specificity, (168) 108; (174) 123 Subtilisin, (167) 210 Subtilisin treatment, (173) 41 Subtype, (170) 378 Subunit composition, (172) 189 Subunit size, (173) 327 a-Subunit, (175) 76 @-Subunit, (178) 10 E-Subunit, (166) 85 30 S Subunit, (173) 155 Succinale oxidation, (178) 187 Sucrose, (167) 69 Sucrose gradient centrifugation, (173) 381 Sucrose stearate-pahnitate, (175) 178 Sugar activation, (170) 295 Sugar phosphate, (169) 12; (178) 137 Sugar specificity, (176) 120 Sugar transport, (170) 55 Sugar uptake, (173) 1 Sugarcane vacuole, (173) 1 Suicide substrate, (174) 275 Sulfate, (178)271 Sulfhydrylgroup,(l73)283;(173)399;(174) 128 Sulfiydrylmodifkation, (168) 121 Sulfhydryl reagent, (165) 185 Sumithione, (173) 147 Super-secondary structure, (166) 33 Superfamily, (165) 190 Superinduction, (166) 199 Superoxide, (170) 69; (170) 157; (172) 239; (178) 25 Superoxide anion, (I 73) 251 Superoxide dependence , (172) 245 Superoxide dismutase, (166) 232; (167) 37; (172) 245 Superoxide generation, (175) 105 Supported lipid layer, (176) 385 Surface activity, (175) 263 Surface antigen, (173) 108; (178) 105 Surface charge density, ( 167) 18 1 Surface coil, (168) 1 Surfacelayer, (173) 185 Surface potential, (167) 181 Surface receptor, (171) 9 SV4ODNA,(l69)211 Sympathetic nerve, (167) 117 Synaptic membrane, (175) 124 Synaptic vesicle, (165) 128 Synaptoneurosome, (175) 193 Synaptosome, (171) 280; (171) 303 Synchrotron radiation, (178) 165

68 Volumes 165-178 (1984)

Thyroliberin, (167) 160 Thyroliberin precursor, (167) 160 Thyrotrophin releasing hormone, (177) 71 Thyrotropin, (166) 136 Thyroxine, (170) 273 Thyroxine-containingpeptide, (175) 140 Time-resolved fluoroimmunoassay, (173) 2 13 Tiron, (173) 251 Tissue disaggregation, (176) 8 Tissue distribution, (173) 327 Tissue plasminogen activator, (175) 412 Tissuespe&icity,(173)374;(174)208;(178)217 TLC,(167)47;(170) 15 TMV,(173)247 Topogenesis, (178) 193 Topographical relationship, (171) 267 Topoisomerase, (176) 431 Topology, (174) 294 Toxin,(165)57;(167)241;(169)25;(171)277;(178)114 T-2 Toxin, (175) 189 TPMP+, (166) 146 Transcript mapping, (175) 37 1 Transcription, (165) 31; (173) 129 Transcription homology, (167) 165 Transcription inhibition, (172) 21 Transcription regulation, (165) 35 Transcription termination, (166) 307 Transcriptional control, (172) 59; (177) 61 Transcriptional regulation, (173) 3 1 Transcriptionally active chromatin, (169) 174 Transducin, (178) 228 Transferrin, (176) 129; (176) 185 Transferrin receptor, (175) 279 Transformation, (176) 479 Transformation related protein, (166) 326 Transformation-sensitive protein, (165) 21; (169) 185 Transformed cell, (168) 129 Transglutaminase, ( 17 1) 22 1 Transglycosylase-transpeptidase, (176) 179 Transglycosylation, (178) 323 Transient dichroism, (175) 329 Transition state, (175) 356 Translation, (166) 104, (168) 161; (176) 32; (176)295; (177) 163;

(178) 283 Translation initiation, (170) 339 Translation regulation, (176) 401 Translational fidelity, (177) 119 Translational initiation, (175) 203 Translocation, (165) 280; (175) 284 Transmembrane, (169) 241 Transmembrane orientation, (176) 355 Transmembraneprotein, (176) 385 Transmembrane proton gradient, (175) 95 Transplantation, (175) 131 Transport protein, (176) 1 Transposon, (168) 249 Trapidil, (172) 167 Triacylglycerol synthesis, (175) 284 Triazine resistance, (175) 243 Trichothecen, (175) 189 Triethyllead chloride, (174) 128 Trifluoperaxine, (166) 373

Synenkephalin, (172) 303 Synovial fluid, (17 1) 285 Synthetic oligonucleotide, (165) 216; (173) 351; (176) 449 Synthetic peptide, (165) 79; (168) 143 Synthetic peptide analogue, (175) 2 19 Synthetic proteinase inhibitor, (172) 159

Tantigen, (168) 129; (170) 125 T-cell, (175) 325 T-cell factor, (171) 41 T-cell growth factor, (177) 200 T-cell hybrid, (171) 41 T lymphocyte, (178) 105 T7 phage, (165) 3 1 TANDEM, (176) 414 Target size, (175) 383; (176) 371 Teichoic acid, (166) 301 Teichoicase, (166) 301 Temperature effect, (168) 327 5’-GRKJGYC-3’ Terminal extension, (177) 57 Tertiary fold, (175) 227 Tertiary structure, (176) 255 Testosterone, (173) 213 Testosterone production, (169) 21 Testosterone synthesis, (172) 177 Tetrodotoxin receptor, (172) 114 Theileriosis, (169) 305 a-Thenoyltritluoroacetone, (175) 105 Theophylline, (166) 199 Theoretical computation, (170) 191; (173) 301 Thermoacidophilic archaebacteria, (171) 63 Thermogenesis, (166) 151 Thermoluminescence, (165) 163 Thermophile, (165) 39 Thermophilicity, (166) 160 Thermotolerance, (172) 299 Thiobarbituric acid assay, (178) 47 Thiobarbituric acid reactivity, (167) 37 Thiolreagent, (171) 303; (174) 128 Thionitrobenxoate, (166) 13 1 Thiopental, (177) 249 Thioredoxin, (170) 76; (172) 11 Thiyl free radical, (177) 295 Three-dimensional structure, (165) 97; (175) 333 Thrombin,(170)43;(171) 157;(172)272;(174)90;(176)202;

(177) 109 Thrombin stimulation, (173) 164 Thrombolysis, (168) 33 Thy-l antigen, (178) 105 Thylakoid development, (177) 269 Thylakoid lipid, (173) 36 Thylakoid membrane, (169) 1; (176) 239 Thylakoid polypeptide, (175) 255 Thymidylate synthetase, (173) 227 Thyroglobulin, (175) 140 Thyroid, (166) 136; (176) 337 Thyroid hormone, ( 17 1) 240; (174) 34 Thyroid perfusion, (170) 273 Thyroid secretion, (170) 273 Thyroid-stimulating hormone receptor, (166) 109 Thyroid-stimulating hormone-thyroid-stimulating hormone

receptor complex, (166) 109

Volumes 165-178 (1984)

Trihydroxypipecolic acid, (176) 6 1 Triiodothyronine,(170)273;(174)34;(177)231 N-Trimethylalanine, (172) 198 Triostin A, (176) 414 Tris-intercalation, (169) 123 Tris washing, (169) 219; (175) 255 Tropomyoin, (168) 169; (173) 164 Troponin C, (176) 144 Troponin T, (171)211 Trypsin, (171) 85 Trypsin cleavage., (173) 357 Trypsin inhibitor, (176) 211; (176) 215 Tryptic digestion, (167) 33 Tryptophan synthase, (173) 381 Tubulin, (168) 278 Tubulin oligomer, (173) 67 Tuftsin, (178) 109 Tumorce.l1,(171)9 Tumor localizer, (172) 267 Tumor necrosis factor, (175) 59 Tumor necrosis factor induction, (167) 226 Tumor promoter, (170) 38 Tunicamycin, (166) 28 Two-dimensional analysis, (173) 337 Two-dimensional gel electrophoresis, (165) 21; (168) 93;

(169) 185 Two-phase system, (171) 271 Two-site model, (165) 280 TYMV, (176) 295 Tyrosine deprotonation, (175) 337 Tyrosine hydroxylase, (175) 37 Tyrosine kinase, (175) 113 Tyrosine pocket, (173) 45 Tyrosine protein kinase, (170) 139 Tyrosine sulfate, (165) 180; (177) 129 Tyrosyl-S-phosphate ester, (173) 351

Ubiquinol-cytochrome c, oxidoreductase, (178) 336; (178) 343 Ubiquinone, (167) 327; (172) 6; (178) 343 Ubiquitin, (169) 199 Ubisemiquinone, (175) 105 Ultracentrifugation, (173) 381 Ultracryotomy, (165) 175 Ultraviolet CD, (176) 355 Ultraviolet-difference spectrum m/D,, (169) 219 Ultraviolet-spectrophotometry, (168) 7 Uncoupler, (166) 233; (177) 11 Uncoupling, (178) 240 Uncoupling protein, (166) 393; (167) 10; (170) 186 Uniform r5N enrichment, (173) 342 Unsaturated fatty acid, (172) 231 Urate inhibition, (174) 147 Urea, (166) 33 1 Ureacycle,(165) 197;(177)41 Urea synthesis, (177) 138 Ureogenesis, (166) 385 Uric acid, (170) 162 Urine inhibitor, (176) 223 Uroporphyrin, (173) 142

V-antigen synthesis, (173) 15 1 Vacuolar membrane, (173) 199

69

Valyl-tRNA synthetase, (174) 20 Vanadate, (174) 71 Vapor-phase sequencer, (174) 228 Variable fluorescence, (17 1) 173 Vascular toxicity, (173) 124 Vasoactive intestinal peptide, (166) 273; (166) 277; (166) 283;

(172) 55; (175) 307; (178) 233 Vasoactive intestinal peptide precursor, (174) 258 Vasoactive intestinal polypeptide, (173) 407; (177) 71 Vasopressin,(l66) 125;(167) 19;(169) 133;(170)310;(177) 175 Vasopressin receptor, (175) 383 Ventromedial hypothalamus, ( 166) 15 1 Vesicle,(171) 160 Vesicle size, (167) 69 Vibrational structure, (167) 186 Vimentin, (170) 259; (171) 107 Vincuhn isolation, (165) 26 Viologen, (166) 76; (167) 29 Viral transformation, (166) 170; (173) 233 Virus adsorption, (175) 329 Virus immobilization, (175) 329 Viscosimetry, (169) 123 Visual excitation, (175) 87 Visual transduction, (168) 2 13 Vitamin C, (168) 287 Vitamin K, (165) 16; (168) 287; (173) 169; (177) 265 Vitamin K-dependent protein, (165) 102 Vitellogenin gene expression, (178) 2 17 Volkensin, (17 1) 277 Voltage dependency Ca2+-channel, (170) 196

Waldenstrdm’s macroglobulinemia, (170) 343 Warfarin, (165) 16; (168) 287 Water oxidation, (175) 255; (178) 51 Water-splitting complex, (176) 346 Waterrtructure, (167) 245; (171) 325; (173) 347 Water suppression, (165) 23 1 Well and turnstile system, (176) 287 Western blotting, (168) 113; (177) 269 Wobble position, (178) 6

X-ray absorption, (178) 165 X-rayanalysis,(165)39;(165)43;(170)229;(174)96 X-ray diffraction, (165) 97; (170) 143 XANES, (178) 165 Xylanase, (171) 197 /?-Xylanase, (178) 323 /?-Xylobiose, (178) 323 j7-Xylosidase, (178) 323

Yeast metabolism, (178) 123 Yohimbine, (170) 387

Z form, (173) 243 Zinc, (169) 313 Zinc content, (174) 20 Zonal tissue ~9, (167) 117 Zopiclone, (173) 255;