failed daa
TRANSCRIPT
Retreatment ofnon-sustained virological responders to DAAs
By
Mohamed FaroukM.sc., Tropical medicine and Gastroenterology
Assiut Center for Control of Viral Hepatitis
M.Farouk ... 2015
Two Questions
What’s Failed DAA ?
What’s HCV Genotype ?
1
2
M.Farouk ... 2015
Ritona-boosted Parita+Ombit+
Dasa
Ritona-boosted Parita+Ombit
Sof+Ledip Sof+Dacl Sof+Simv Genotype Failed treatment
Yes No Yes Yes Yes 1 Sof alone,Sof + Ribv
Sof +PegINF+RibvNo No No Yes No 2or3
No Yes Yes Yes Yes 4
No No Yes Yes No 5or6
No No Yes Yes No 1or4 Sof+Simv
No No No No Yes 1 Sof+DaclOr
Sof+LedipNo No No Yes No 2or3
No No No No Yes 4
No No Yes Yes No 5or6
No No Yes Yes Yes 4 Ritona-boosted Parita+Ombit
Yes = 12wk+Ribv Or 24wk+Ribv if F3 or cirrhosis No = not recommended for retreatmentM.Farouk ... 2015
M.Farouk ... 2015
Should we do genotyping before retreatment?
Should we do genotyping before initial therapy?
Is giving ribavirin to patients with intolerance to it, anaemia. Cirrhosis is suitable? and if not what should we do? ?
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Should I choose a pangeotypic rigemen instead, like daclatasvir?
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