faculty klingmüller(final) 2013 - heidelberg university · faculty(! ursula(klingmüller,(phd(!...
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Faculty Ursula Klingmüller, PhD Research Interests Systems biology of signal transduction Quantitative analysis of information processing Identification of key regulatory mechanisms Prediction of strategies for effective intervention in cancer
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Short CV Affiliation Ursula Klingmüller Professor University of Heidelberg Head of the Division Systems Biology of Signal Transduction, German Cancer Research Center Scientific Co-‐coordinator of the Disease Area Lung Cancer of the German Center for Lung Research Division ‘Systems Biology of Signal Transduction’ German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 69120 Heidelberg Tel: +49 (0)6221 42-‐4481 Fax: +49 (0)6221 42-‐4488 e-‐mail: u.klingmueller@dkfz-‐heidelberg.de Homepage: http://www.dkfz.de/de/systembiologie/index.php Curriculum Vitae 1985 1988
Bachelor of Science, University of Bayreuth, Germany Diploma in molecular biology, cell biology and virology, University of Heidelberg, Germany
1992
Graduate studies at the University of Heidelberg Doctoral Thesis (summa cum laude), Center for Molecular Biology Heidelberg (ZMBH)
1992-1993
Postdoctoral fellow, Harvard Medical School, Boston, USA
1993- 1996
Postdoctoral Fellow, Whitehead Institute for Biomedical Research, Cambridge, USA
1996- 2003
Group leader of an independent junior group (Hans-‐Spemann-‐Laboratories), Max-‐Planck-‐Institute for Immunbiology, Freiburg, Germany
2000
Habilitation and Venia Legendi in Molecular Biology and Genetics, University of Freiburg, Germany
2003- 2007
Leader of the Boveri-‐Group ‘Systems Biology of Signal Transduction’, German Cancer Research Center (DKFZ), Heidelberg, Germany
2004 Venia Legendi in Cell Biology, University of Heidelberg, Germany 2007 – present
Head of the division ‘Systems Biology of Signal Transduction’, German Cancer Research Center (DKFZ), Heidelberg, Germany
2011- present
W3 Professor Systems Biology of Signal Transduction, University of Heidelberg, Germany
Honours & Awards 1997 FEBS Anniversary Prize
2004 R. Eils, U. Klingmüller, O. Wiestler, E. Wanker,. A.-‐P. Zeng, R. Balling. ‘Systems Biology of Complex Diseases’ Ideenwettbewerb Helmholtz Association
2007-‐
present
Board of Trustees German Cancer Research Center (DKFZ), Member of board of directors of the DKFZ-‐ZMBH Alliance
2012-‐
present
Elected Member of the DFG "Hinterzartner Kreis"
Projects Current research activities cover three main topics:
1. Unraveling principal mechanisms of erythropoietin (Epo) mediated cellular decisions in the hematopoietic system. Our aim is to develop strategies for the establishment of an integrative mathematical model comprising signal transduction, gene regulation and physiological responses of Epo in hematopoietic system and to unravel general design principles controlling cellular decisions. This knowledge will enable the design of strategies for the targeted expansion of erythroid progenitor cells to counteract anemia.
2. Bridging from the cellular to the whole organ level during liver regeneration. Within the network Virtual Liver we are currently establishing integrative models addressing pathway crosstalk, regulation through microRNAs and cell-‐cell communication. A main goal of the Virtual Liver is to link data-‐based mathematical models across scales to establish a reliable framework to quantitatively predict physiological responses of the liver.
3. Insights into altered regulation in lung cancer and prediction of strategies for efficient intervention. In the CancerSys network LungSysII and the DZL we are addressing the dynamics of signaling pathways at the cell population and single cell level in close collaboration with clinicians and partners from companies. This will be performed in lung cancer cell lines representative for key alterations observed in lung cancer, which are cultivated either in monolayer, as spheroid or xenograft. By integrating dynamic pathway models, spatio-‐temporal models and multi-‐scale models, our aim is to link the extent of pathway activation to migratory and proliferative decisions and thereby unravel mechanisms promoting early spread in lung cancer.
Current Funding Federal Ministry of Research (BMBF) 2012-‐2015 German Center for Lung Research DZL
Federal Ministry of Research (BMBF) 2013-‐2016 „LungSys – Systems Biology of Lung Cancer – Dynamic Properties of Early Spread and Therapeutic Options”
DKFZ NCT-‐POP 2013 -‐ 2016 Comprehensive characterization of Non Small Cell Lung Cancer (NSCLC) by integrated clinical and molecular analysis
Helmholtz Association 2007 -‐ 2012 SBCancer: Systems Biology of Signaling in Cancer
Federal Ministry of Research (BMBF) 2013 -‐ 2015 SBEpo – Systems Biology of Erythropoetin
Deutsches Forschungsgemeinschaft (DFG – KFO) 2013 -‐ 2016 Mechanisms of persistence of hepatotropic viruses FOR1202
Federal Ministry of Research (BMBF) 2010-‐2015 Virtual Liver Network
EU IMI-‐Project 2012 -‐ 2017 MIP-‐DILI -‐ Mechnism-‐Based Integrated Systems for the Prediction of Drug-‐Induced Liver Injury
Federal Ministry of Research (BMBF) 2013 -‐ 2015 Immunoquant – Multiscale Modeling of Innate Immunity
National Institute of Health (NIH) 2011 -‐ 2014 Systems analysis of TGFbeta signaling and SnoN function
Team
Post-‐doctoral fellows Dr. Marcel Schilling Tel.: +49 (0)6221 42-‐4485 Email: [email protected] Dr. Sofia Depner Tel.: +49 (0)6221 42-‐4485 Email: [email protected] Dr. Lorenza D`Alessandro Tel.: +49 (0)6221 42-‐4482 Email: l.dalessandro@dkfz-‐heidelberg.de Dr. Agustin Rodriguez Tel.: +49 (0)6221 54-‐51243 Email: a.rodriguez@dkfz-‐heidelberg.de Dr. Fransziska Herrmann Tel.: +49 (0)6221 42-‐4490 Email: f.herrmann@dkfz-‐heidelberg.de Dr. Stephanie Müller Tel.: +49 (0)6221 42-‐4482 Email: st.mueller@dkfz-‐heidelberg.de Dr. Marie-‐Christine Wagner Tel.: +49 (0)6221 42-‐4490 Email: marie-‐christine.wagner@dkfz-‐heidelberg.de PhD Students Lorenz Adlung Tel.: +49 (0)6221 42-‐4492 Email: l.adlung@dkfz-‐heidelberg.de Svantje Braun Tel.: +49 (0)6221 42-‐4483 Email: [email protected] Sajib Chakraborty Tel.: +49 (0)6221 42-‐4492 Email: [email protected] Dmytro Dvornikov Tel.: +49 (0)6221 42-‐4482 Email: [email protected] Xiaoyun Huang Tel.: +49 (0)6221 42–4483 Email: [email protected] Nao Iwamoto Tel.: +49 (0)6221 42–4485 Email: [email protected]
Frédérique Kok Tel.: +49 (0)6221 42–4490 Email: [email protected] Philippe Lucarelli Tel.: +49 (0)6221 42–4482 Email: [email protected] Ruth Merkle Tel.: +49 (0)6221 42–4492 Email: [email protected] Florian Salopiata Tel.: +49 (0)6221 42–4490 Email: [email protected] Tibor Szekeres Tel.: +49 (0)6221 42–4483 Email: [email protected] Katharina Waldow Tel.: +49 (0)6221 42–4490 Email: [email protected] Technical and IT Support Markus Stepath Tel.: +49 (0)6221 42-‐4482 Email: m.stepath@dkfz-‐heidelberg.de Technical Assistants Susen Lattermann Tel.: +49 (0)6221 42–4482 Email: [email protected] Sandra Manthey Tel.: +49 (0)6221 42–4483 Email: s.manthey@dkfz-‐heidelberg.de Secretariat Martina Kegel Tel.: +49 (0)6221 42–4486 Email: m.kegel@dkfz-‐heidelberg.de
Selected Publications 1. Swameye, I., Müller, T. G., Timmer, J., Sandra, O., and Klingmüller, U., Identification of
nucleocytoplasmic cycling as a remote sensor in cellular signaling by data-‐based dynamic modeling. Proc. Natl. Acad. Sci. USA (2003), 100:1028-‐33.
2. Schilling, M., Maiwald, T., Hengl, S., Winter, D., Kolch, W., Lehmann, W. D., Timmer, J., and Klingmüller, U., Combined Theoretical and Experimental Analysis Links Isoform-‐specific MAP-‐kinase Signaling to Cellular Decisions. Molecular Systems Biology (2009), 5:334.
3. Becker, V., Schilling, M., Bachmann, J., Baumann, U., Raue, A., Maiwald, T., Timmer, J., and Klingmüller, U., Covering a Broad Dynamic Range – Information Processing at the Erythropoietin Receptor. Science (2010) 328(5984):1404-‐1408.
4. Bachmann, J., Raue, A., Schilling, M., Boehm, ME., Kreutz, C., Kaschek, D., Busch, H., Gretz, N., Lehmann, WD., Timmer, J., Klingmüller, U. Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Molecular Systems Biology (2011) 7, Art.Nr. 516.
5. Raia, V., Schilling, M., Böhm, M., Hahn, B., Kowarsch, A., Raue, A., Sticht, C., Bohl, S., Saile, M., Möller, P., Gretz, N., Timmer, J., Theis, F., Lehmann, WD., Lichter, P., and Klingmüller, U. Dynamic Mathematical Modeling of IL13-‐induced Signaling in Hodgkin and Primary Mediastinal B-‐cell Lymphoma Allows Prediction of Therapeutic Targets. Cancer Research (2011), 71(3), 693-‐704