EVE SYRKIN WURTELE

Professor

Department of Genetics, Development and Cell Biology

Iowa State University

Ames, IA 50011

515 294-2023 (phone)

515 290-3232 (cell)

515 294-1337 (FAX)

mash@iastate.edu

Degrees Awarded

Degree Institution Major Year

B.S. U.C. Santa Cruz Biology 1971

Ph.D. U.C. Los Angeles Biology 1980

Professional

Position Department Institution Years

Postdoctoral Fellow Biochemistry U.C. Davis 80-83

Senior Research Scientist Cell Biology Division NPI, Inc. 83-88

Affiliate Assistant Professor Botany and Food Tech. Iowa State University 88-90

Assistant Professor Botany Iowa State University 90-95

Associate Professor Botany Iowa State University 95-99

Professor GDCB Iowa State University 99-present

Member of Interdepartmental Programs at Iowa State University

Molecular Cellular and Developmental Biology

Interdepartmental Genetics Major

Interdepartmental Plant Biology Major

Bioinformatics and Computational Biology

Human and Computer Interactions Program

Laurence Baker Center for Bioinformatics and Computational Biology

Center for Metabolic Biology

Metabolic Informatics

Committee on Plant Sciences (1996) - initiated bioinformatics emphasis at ISU

PI, MetNet, software to identify and visualize metabolic and regulatory networks in plants.

Organizer: two international symposia on Plant Metabolic Networking.

PI, Meta!Blast, 3D videogame for cell and metabolic biology

PROFESSIONAL SERVICE

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Organizer of Conferences

Third International Congress on Plant Metabolomics, PSI Symposium, June, 2004, Iowa State

University. Supported in part by awards from NSF and USDA. (275 attendees, more than half

of these were international participants)

Metabolic Networking in Plants, April, 1999, First in a series of international symposia on Plant

Molecular Biology and Biochemistry at Iowa State University. Supported in part by

awards from NSF and USDA.

North Central Soybean Transformation Meeting, October, 1997, Iowa State University.

Hosted 26 researchers in soybean transformation for a two day intensive meeting and

laboratory tour

Panel/Study Section member

US Department of Agriculture

Biochemistry (one panel)

National Science Foundation

Metabolic Biochemistry (six panels)

Arabidopsis 2010 (one panel)

Interagency Metabolic Engineering: Systems Biology (one panel)

Systems Biology (one panel)

Advances in Biological Informatics (one panel)

National Institutes of Health

Modeling and Analysis of Biological Systems (study section: seven panels)

SEPA (two panels)

Member, International Advisory Board for Academic Freedom, Bar Ilan University. 2005-present

Editorial Board

Journal of Botany

BMC Plant Biology

Plant

Amercan Association for Plant Biology

Eric E. Conn Award, selection committteee

Referee for grants submitted to Federal agencies: USDA, NSF, DOE, NIH, BARD

Referee for manuscripts submitted to scientific journals: Plant Physiology, American Journal of Botany,

Computational and Functional Genomics, Physiologia Plantarum, Phytochemistry, Journal of Crop

Science, Genetics, Plant Cell, Trends in Plant Biology.

Multinational Arabidopsis Steering Committee: Subcommittee on Systems Biology

AWARDS

2013 Meta!Blast 3D interactive application for cell and metabolic biology: The Leaf

Peoples Choice Winner 2013 International Science and Engineering Visualization

Challenge. (Featured in Science Feb 7, 2014)

2012 Winner Pioneer Dupont Award for Iowa Woman of Research Innovation and

Leadership

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2012 Meta!Blast 3D interactive application for cell and metabolic biology:The Lgiht

Reactions. Finaslist. (Winners announced Feb. 2013) International Science and

Engineering Visualization Challenge.

2012 Meta!Blast 3D interactive application for cell and metabolic biology. Level 1: the cell.

Honorable mention 2011 International Science and Engineering Visualization

Challenge. Featured in: Science 335:533.

2012 International Science and Engineering Challenge Finalist, Illustration (The Cytosol).

Science Magazine and National Science Foundation

2010 Meta!Blast entry-Finalist Learning Lab, (top 5% of >1000 submissions)MacArthur

Foundation,

2010 Meta!Blast entry-Second Place, Chlorofilms

2006 Research Excellence Award, College of LAS, Iowa State University

2005 Team Award, “Acetyl-CoA Biology”, Iowa State University

1997 American Chemical Society, Herman Frasch Foundation Award

META!BLAST: MUSEUM AND CONFERENCE EXHIBITS:

2015-02-24 Museums of the National Council of Science Museums of India (NCSM) Poster

and computer game exhibit LAUNCHES, seminars and workshops at: National

Science Museum, Delhi; Kunushetra; Ahmedabad; and Jaipur.

2012-2014 Museums of the National Council of Science Museums of India (NCSM)

http://www.ncsm.org.in/ : Meta!Blast computer game. Module: The Cell. Science

City, Kolkata (1.5 million visitors/y) (permanent exhibit, established in

NanoScience Lab as a team-based computer game for high school students, and in

main Rotunda as a single-player interactive exhibit for the public); established as

single-player interactive exhibit for the public at: NCSM Regional Science

Museum, Callicut; Karala State Science and Technology

Museum,Thiruvananthapuram, NCSM District Science Museum, Tirunelveli.

2012 Featured at American Association for Advancement of Science Annual Meeting

2010-pres. Science City, Calcutta, India. 1.5 million vistors anually. Permanent exhibit

2010 Museums of the National Council of Science Museums of India (NCSM)

http://www.ncsm.org.in/ : Meta!Blast posters exhibits for Biodiversity Year, Spring,

2010, and Meta!Blast videogame and guides, November 2010- LAUNCH

Birla Industrial & Technological Museum, Calcutta (Headquarters)

Science City, Calcutta

Biotechnology Gallery of Visvesvaraya Industrial & Technological Museum,

Bangalore,

Regional Science Centre, Guwahati, Assam

Nehru Science Centre Mumbai

Local NCSM science centers at Kalimpong, Gangtok, Siliguri

2009 Birla Science Center Exihibit, Hyderabad, India.

PUBLICALLY AVAILABLE DATABASES, SOFTWARE AND EDUCATIONAL WEBSITES

(Wurtele, PI)

PMR database and analysis for combined metabolomics and transcriptomics of plants and

microorganisms.

http://metnetdb.org/PMR/

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MedicinalPlantsMetabolomics Resource:

http://metnetdb.org/mpmr_public/

MetNet Database and Software for Bioinfomatics:

http://metnetdb.org/

Meta!Blast videogame for metabolic biology:

http://metablast.org

PUBLICATIONS

Book Editor:

Nikolau BJ, Wurtele ES. 2007. Concepts in Plant Metabolomics. Springer. 297 pgs.

Invited book chapters:

1. Crispin MC, Wurtele ES. 2012. Use of Metabolomics and Transcriptomics to Gain Insights into

the Regulation and Biosynthesis of Medicinal Compounds: Hypericum as a Model. Chapter 18 In:

S Chandra, H Lata, AVarma, ed., Biotechnology for Medicinal Plants: Propagation and

improvement. Springer. pp 395-411.

2. Kher S, Peng J, Wurtele ES, Dickerson J. 2012. Hierarchical Biological pathway data integration

and mining.

3. Oliver DJ, Nikolau BJ, Wurtele ES. 2009. Life at the metabolic nexus. Plant Science, 176:597-

601

4. Berleant D, Ding J, Hughes L, Fulmer A, Wurtele ES, Viswanathan K, Schnable PS. 2008.

PathBinderH: a tool for sentence-focused, plant taxonomy-sensitive access to the biological

literature, chapter 5 in G. P. Rao, C. Wagner & R. K. Singh, eds., Application of Genomics and

Bioinformatics in Plants, Studium Press LLC, Houston, pp 121-136.

5. Wurtele ES, Li L, Berleant D, Cook D, Dickerson JA, Ding J, Hofmann H, Lawrence M, Lee

EK, Li J, Mentzen W, Miller L, Nikolau BJ, Ransom N, Wang Y, 2007. “MetNet: Systems

Biology Software for Arabidopsis.” In: Concepts in Plant Metabolomics. Springer. pp 145-158.

6. Gatlin DM, Barrows FT, Brown P, Dabrowski K, Gaylord TG, Hardy RW, Herman E, Hu G,

Krogdah J, Nelson R, Overturf K, Rust M, Sealey W, Skonberg D, Souza EJ, Stone D, Wilson R

Wurtele E. 2007. Expanding the utilization of sustainable plant products in aquafeeds: a review.

Aquaculture Research, 38:551-579 (691 citations)

7. Dickerson JA, Berleant DA, Du P, Ding J, Foster CM, Ling L, Wurtele ES. 2005. Creating

modeling and visualizing metabolic networks. In Medical Informatics. Eds. H Chen, SS Fuller, C

Friedman, W Hirsch. Springer Verlag. 491-518.

8. Nikolau BJ, Ohlrogge JB, Wurtele ES 2003 Plant Biotin-Containing Carboxylases. Arch

Biochem Biophys. 414:211-222. (167 citations)

9. Oliver DJ, Nikolau B, Wurtele ES. 2002 Functional genomics: high-throughput mRNA, protein,

and metabolite analyses. Metab Eng. 4:98-106.

10. Wurtele ES, Nikolau BJ. 2000. Methylcrotonyl-CoA Carboxylase. Methods in Enzymology

324:280-292.

11. Fatland B, Anderson M, Nikolau BJ, Wurtele ES. 2000. Molecular biology of cytosolic acetyl-CoA generation.

Biochem Soc Trans. 28:593-595.

12. Nikolau BJ, Oliver DJ, Schnable P, Wurtele ES. 2000. Molecular biology of acetyl-CoA

metabolism. Biochem Soc Trans. 28:591-593.

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Papers in refereed journals:

1. Li L, Zheng W, Zhu Y, Ye H, Tang B, Arendsee Z, Jones D, Li R, Ortiz D, Zhao X, Du C,

Nettleton D, Scott P, Salas-Fernandez M, Yin Y, Wurtele ES. 2015. The QQS orphan gene

regulates carbon and nitrogen partitioning across species via NF-YC interactions. Proc. Nat.

Acad. Sci. ePub Nov 2015 doi:10.1073/pnas.1514670112.

http://www.pnas.org/content/112/47/14734

2. Kim T, Dreher K, Nilo-Poyanco R, Lee I, Fiehn O, Lange BM, Nikolau BJ, Sumner L, Welti R,

Wurtele ES, Rhee SY. Patterns of metabolite changes identified from large-scale gene

perturbations in Arabidopsis thaliana using a genome-scale metabolic network. Plant Physiol.

2015 Feb 10. pii: pp.114.252361. [Epub ahead of print] PubMed PMID: 25670818.

3. Li L, Hur M, Lee JY, Zhou W, Song Z, Ransom N, Demirkale C, Nettleton D, Westgate M,

Arendsee Z, Iyer V, Shanks J, Nikolau B, Wurtele E. A systems biology approach toward

understanding seed composition in soybean. BMC Genomics. 2015;16 Suppl 3:S9. doi:

10.1186/1471-2164-16-S3-S9. Epub 2015 Jan 29. PubMed PMID: 25708381.

4. Arendsee Z, Li L, Wurtele ES. 2014. Coming of age: orphan genes of plants. Trends in Plant

Science. www.cell.com/trends/plant-science/supplemental/S1360-1385(14)00193-9

5. Li L, Wurtele ES. 2014. The QQS orphan gene of Arabidopsis modulates carbon and nitrogen

allocation in soybean. Plant Biotechnology Journal. doi: 10.1111/pbi.12238

6. Fukushima A, Kusano M, Mejia RF, Iwasa M, Kobayashi I, Hayashi N, Watanabe-Takahashi

A, Narisawa T, Tohge T, Hur M, Wurtele ES, Nikolau BJ, Saito K. 2014. Metabolomic

Characterization of Knock-Out Mutants in Arabidopsis - Development of a Metabolite Profiling

Database for Knock-Out Mutants in Arabidopsis (MeKO). Plant

Physiol. doi:10.1104/pp.114.240986

7. Hur M, Campbell AA, Almeida-de-Macedo M, Li L, Ransom N, Jose A, Crispin M, Nikolau BJ,

Wurtele ES. 2013. A global approach to analysis and interpretation of metabolic data for plant

natural product discovery. Natural Product Reports. Feb, DOI:10.1039/C3NP20111B

8. Crispin MC, Hur M, Park T, Kim YH, Wurtele ES. 2013 Identification and biosynthesis of

acylphloroglucinols in Hypericum gentianoides. 148:354-70. doi: 10.1111/ppl.12063.

PMID:23600727

9. Almeida-de-Macedo MM, Ransom N, Feng Y, Hurst J, Wurtele ES. Comprehensive analysis of

correlation coefficients estimated from pooling heterogeneous microarray data. BMC

Bioinformatics. 2013 Jul 4;14(1):214. doi: 10.1186/1471-2105-14-214. PubMed PMID: 23822712;

PubMed Central PMCID: PMC3765419.

10. Wurtele ES, Bassham D, Haynes G, Klippel P, Navratil A, Ganga Rautela G, Schneller W, Shah

A. 2013. Meta!Blast: an interactive environment for learning and informal education. Proceedings

ICON-CIMUSET- 2013, Rio de Janeiro.

http://www.cimuset.org/cms/contentmanager.do?name=Articles&method=view&pageid=view&id

=cms0780079808141&biaotiid=3

11. Crispin MC, Hur M, Park T, Kim YH, Wurtele ES. Identification and biosynthesis of

acylphloroglucinols in Hypericum gentianoides. Physiol Plant. 2013 148:354-70. doi:

10.1111/ppl.12063. PubMed Central PMCID: PMC3687794.

12. Zhang L, Berleant D, Ding J, Wurtele ES. 2013. Automatic extraction of biomolecular interaction

terms with text empirics. BMC Bioinformatics 14:234 http://www.biomedcentral.com/1471-

2105/14/234

13. Chen X, Chou H, Wurtele ES. 2013. Holocarboxylase synthetase1 physically interacts with

histone H3 in Arabidopsis. Scientifica. Article ID 983501. http://dx.doi.org/10.1155/2013/983501

14. Yeo YS, S. Nybo E, Chittiboyina AG, Weerasooriya AD, Wang YH, Góngora‐ Castillo E,

Vaillancourt B, Buell CR, DellaPenna D, Celiz MD, Jones AD, Wurtele ES, Ransom N,

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Dudareva N, Shabaan KA, Tibrewal N, Chandra S, Smillie T, Khan IA, Coates RM, Watt DS,

Chappell J. 2012. Functional identification of valerena-1,10-diene synthase, a terpene synthase

catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in

Valeriana officinalis. J Biol Chem. doi:10.1074

15. Ngaki MN, Louie GV, RN, Manning G, Pojer F, Bowman ME, Li L, Elise Larsen E, Wurtele ES,

Noel JP. 2012. Evolution of the chalcone isomerase fold from fatty acid-binding to stereospecific

enzyme. Nature. 485:530-533. doi:10.1038/nature11009

16. Wurtele ES, ChappellJ, Jones AD, Celiz MD, Ransom N, Hur M, Rizshsky L, Dixon P Liu J,

Widrlechner MP, Nikolau BJ. 2012. Medicinal Plants: A Public Resource for Metabolomics and

Hypothesis Development. Metabolites. 2(4), 1031-1059; doi:10.3390/metabo2041031 -

17. Feng YP, Hurst J. Almeida-De-Macedo M. Chen X. Li L. Ransom N, Wurtele ES. 2012. A

massive human co-expression-network and its medical applications. Special Issue: Molecular

Networks and Disease. Systems Biology, Chemistry & Biodiversity. May;9 (5):868-87. doi:

10.1002/cbdv.201100355 PMID: 22589089

18. Zhang L, Berleant D, Ding J, Wurtele ES. 2012. BirdsEyeView (BEV): graphical overviews of

experimental data. Automatic extraction of biomolecular interaction terms with text empirics.

BMC Bioinformatics. 13 Suppl 15:S11.-15. doi: 10.1186/1471-2105-13-S15-S11.

19. Schneller W, Campbell PJ, Bassham D, Wurtele ES 2012. Meta!Blast computer game: a pipeline

from science to 3D art to education. The Engineering Reality of Virtual Reality, Eds: McDowall

IE, Dolinsky M. International Society for Optics and Photonics.

SPIE 828905. http://dx.doi.org/10.1117/12.911289

20. Quanbeck SMM, Brachova L, Campbell AA, Guan X, Perera A, Seung KA, Rhee Y, Bais P,

Dickerson J, Dixon P, Wohlgemuth G, Fiehn O, Barkan L, Lange BM, Lee I, Cortes D, Shuman J,

Shulaev V, Huhman D, Lei Z, Sumner LW, Roth MR, Welti R, Ilarslan H, Wurtele ES, Nikolau

.BJ. 2012. Metabolomics as a hypothesis-generating functional genomics tool for the annotation of

Arabidopsis thaliana genes of "unknown function" Frontiers of Plant Science. doi:

10.3389/fpls.2012.00015

21. Sucaet Y, Wang Y, Jie Li J, Wurtele ES. 2012 MetNet Online: a novel integrated resource for

plant systems biology. BMC: Bioinformatics. 13:267 doi:10.1186/1471-2105-13-267

22. Ding G, Che P, Ilarslan H, Wurtele ES, Nikolau BJ. 2012. Genetic dissection of methylcrotonyl-

CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed

development and germination. Plant Journal. doi: 10.1111/j.1365-313X.2011.04893.x

23. Peng J, Ilarslan H, Wurtele ES, Bassham DC. 2011. AtRabD2b and AtRabD2c have overlapping

functions in pollen development and pollen tube growth. BMC Plant Biology. 11:25

24. Stenerson M, Schneller W, Wurtele ES. 2012. Enabling Educators to Customize the Game

Environment. Procedings of Games, Learning and Society Conference, 2011.

http://www.etc.cmu.edu/etcpress/content/gls-70-conference-proceedings

25. Li X, Ilarslan H, Brachova L, Qian HR, Li L, Che P, Wurtele ES, Nikolau BJ. 2011 Reverse

genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-CoA

carboxylase in Arabidopsis thaliana indicates a unidirectional functional redundancy. Plant

Physiol. PubMed PMID: 21030508.

26. Sucaet Y, Wurtele ES. 2010. MetNetAPI: A flexible method to access and manipulate biological

network data from MetNet. BMC Res Notes. 3:312. PubMed PMID: 21083943; PubMed Central

PMCID: PMC2998519.

27. Wu L, Rowe EW, Jeftinija K, Jeftinija S, Rizshsky L, Nikolau BJ, McKay J, Kohut M, Wurtele

ES. 2010. Echinacea-induced cytosolic Ca2+ elevation in HEK293. BMC Complement Altern

Med.10:72. PubMed PMID: 21092239; PubMed Central PMCID: PMC3002894.

28. Jia M,Li L,Boggess E, Wurtele ES, Dickerson JA. 2010. "Visualizing Multivariate Hierarchic

Data Using Enhanced Radial Space-Filling Layout," in Advances in Visual Computing. 6453:

Springer Berlin / Heidelberg, pp. 350-360.

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29. Jia M, Chio SY, Rieners D, Wurtele ES, Dickerson J. 2010. MetNetGE:Interactive views of

biological networks and ontologies. BMC Bioinformatics 11:469-476

30. Bais P, Moon SM, He K, Leitao R, Dreher K, Walk T, Sucaet Y, Barkan L, Wohlgemuth G, Roth

MR, Wurtele ES, Dixon P, Fiehn O, Lange BM, Shulaev V, Sumner LW, Welti R, Nikolau BJ,

Rhee SY, Dickerson JA. 2010. PlantMetabolomics.org: a web portal for plant metabolomics

experiments. Plant Physiol. 152:1807-1816. Epub 2010 Feb 10.

31. Wurtele ES, Bassham DC, Dickerson J, Kabala DJ, Schneller W, Stenerson M, Vasanth A. 2010.

Meta!Blast: A serious game to explore the complexities of cell and metabolic biology. Proceedings

of the ASME 2010 World Conference on Innovative Virtual Reality. WINVR2010

32. Lalone CA, Huang N, Rizshsky L, Yum MY, Singh N, Hauck C, Nikolau BJ, Wurtele ES, Kohut

ML, Murphy PA, Birt DF. 2010.Enrichment of Echinacea angustifolia with Bauer alkylamide 11

and Bauer ketone 23 increased anti-inflammatory potential through interference with cox-2

enzyme activity. J Agric Food Chem. 58:8573-84. PMID: 20681645

33. Jia M, Swaminathan S, Wurtele E, Dickerson J, 2009. MetNetGE: Visualizing Biological

Networks in Hierarchical Views and 3D Tiered Layouts. IEEE Computer Society Proceedings.

Top accessed article

34. El Kaissi M, Jia M, Dickerson J, Wurtele ES, Reiners D. 2009. Reaction centric layout for

metabolic networks. Lecture Notes in Computer Science. Springer-Verlag,

35. El Kaissi M, Jia M, Dickerson J, Wurtele ES, Reiners D. 2009.Visualization of gene regulatory

networks. Lecture Notes in Computer Science. Springer-Verlag.

36. Zhai Z, Haney DM, Wu L, Solco AK, Murphy PA, Wurtele ES, Kohut ML, Cunnick JE. Alcohol

extract of Echinacea pallida reverses stress-delayed wound healing in mice.. 2009 Phytomedicine

16:669-78. Epub 2009 Mar 20. PubMed PMID: 19303756;

37. Berleant D, Zhang L, Jing Ding J, Cao T, Xu J, Fulmer A, Wurtele ES. 2009. PathBinder--text

empirics and automatic extraction of biomolecular interactions. BMC Bioinformatics. 11:S18

(software application)

38. Ding J, Berleant D, Xu J, Juhlin K, Wurtele ES, Fulmer A. 2009. GeneNarrator: Mining the

Literaturome for Relations Among Genes. J Proteomics Bioinform 2: 360-371.

39. Li L, Foster C, Gan Q, Nettleton D, James MG, Myers AM, Wurtele ES.2009. Identification of

the novel protein QQS as a component of the starch metabolic network in Arabidopsis leaves.

Plant Journal. Online 2/09 http://www3.interscience.wiley.com/cgi-

bin/fulltext/121641416/HTMLSTART

40. Zhai Z, Solco A, Wu L, Wurtele ES, Kohut ML, Murphy PA, Cunnick JE. 2009. Echinacea

increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells

indicative of alternative macrophage activation. J Ethnopharmacol. 122:76-85

41. Birt DF, Widrlechner MP, Hammer KD, Hillwig ML, Wei J, Kraus GA, Murphy PA, McCoy J,

Wurtele ES, Neighbors JD, Wiemer DF, Maury WJ, Price JP. 2009. Hypericum in infection:

Identification of anti-viral and anti-inflammatory constituents. Pharm Biol. 47:774-782.

42. LaLone CA, Rizshsky L, Hammer KD, Wu L, Solco AK, Yum M, Nikolau BJ, Wurtele ES,

Murphy PA, Kim M, Birt DF. 2009. Endogenous levels of Echinacea alkylamides and ketones are

important contributors to the inhibition of prostaglandin E2 and nitric oxide production in cultured

macrophages. J Agric Food Chem. 57:8820-8830

43. Senchina DS, McCann DA, Flinn GN, Wu L, Zhai Z, Cunnick JE, Wurtele ES, Kohut ML. 2009.

Echinacea tennesseensis ethanol tinctures harbor cytokine- and proliferation-enhancing capacities.

Cytokine 46:267-272

44. Zhai Z, Haney DM, Wu L, Solco AK, Murphy PA, Wurtele ES, Kohut ML, Cunnick JE. 2009.

Alcohol extract of Echinacea pallida reverses stress-delayed wound healing in mice.

Phytomedicine. 16:669-678

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45. Perera A, Choi SY, Wurtele ES, Nikolau BJ. 2009. Quantitative analysis of acyl-coenzyme As in

plant tissues by an LC-MS-MS electrospray ionization method. Chromatography B. Available

online 1/09

46. Mentzen W, Wurtele ES. 2008. Regulon Organization of Arabidopsis. BMC Plant Biology. 8:99

Sept 30 http://www.biomedcentral.com/1471-2229/8/99 highly accessed article (66 citations)

47. Mentzen W, Peng JL, Nikolau BJ, Wurtele ES. 2008. Articulation of Core Metabolic Processes in

Arabidopsis. BMC Plant Biology 8:76. http://www.biomedcentral.com/1471-2229/8/76

48. Lawrence M, Cook D, Lee EK, Babka H, Wurtele ES. 2008. Explorase: Multivariate Exploratory

Analysis and Visualization. 25Apr http://www.jstatsoft.org/v25/i09

49. Cha S, Zhang H, Ilarslan HI, Wurtele ES, Brachova L, Nikolau BJ, Yeung ES. 2008. Direct

profiling and imaging of plant metabolites in intact tissues by using colloidal graphite-assisted

laser desorption ionization (GALDI) mass spectrometry. Plant Journal 55:348-360.

http://www3.interscience.wiley.com/cgi-bin/fulltext/120123728/HTMLSTART

50. Hillwig ML, Hammer KD, Birt DF, Wurtele ES. 2008. Characterizing the metabolic fingerprint

and anti-inflammatory activity of Hypericum gentianoides. J Agric Food Chem. 56:4359-4366

51. Kher S, Peng J, Wurtele ES, Dickerson J. 2008. A Symbolic Approach to Evidence Code

Mapping for Biological Data Integration and Subjective Analysis for Reference Associations for

Metabolic Pathways. NAFIPS 2008. Special Biosciences Section:1-6.

52. Birt DF, Widrlechner MP, Hammer KD, Hillwig ML, Wei J, Kraus GA, Murphy PA, McCoy J,

Wurtele ES, Neighbors JD, Wiemer DF, Maury WJ, Price JP. 2009. Hypericum in Infection:

Identification of Anti-viral and Anti-inflammatory Constituents. Pharm Biol. 47:774-782. PMID:

19907671

53. Xia T, Li J, Wurtele ES, Gu X: 2007. A tool for comprehensive analysis of protein interaction

networks. In BIOCOMP 2007. Eds. Arabnia HR, Yang MQ, Yang JY. pp 523-527

54. Wu L, Dixon PM, Nikolau BJ, Kraus GA, Widrlechner MP, Wurtele ES. 2008. Metabolic

Profiling of Echinacea Genotypes and a Test of Alternative Taxonomic Treatments. Planta

Medica. 75:178-183. Epub 2008 Dec 19.

55. Hammer, K.D.P., Hillwig, M.L., Neighbors, J.D., Sim, Y-J., Kohut, M, Wiemer, D.F. Wurtele,

E.S., and Birt, D.F. 2008. Pseudohypericin is necessary for light-activated inhibition of

prostaglandin E2 pathways by Hypericum perforatum. Phytochemistry

56. Birt DF, Widrlechner MP, LaLone CA, Wu L, Bae J, Solco AK, Kraus GA, Murphy PA, Wurtele

ES, Leng Q, Hebert SC, Maury WJ, Price JP. 2008. Echinacea in infection. American Journal of

Clinical Nutrition, 87(suppl):488S-492S

57. Hammer KDP, Hillwig ML, Solco AK, Dixon PM, Delate K, Murphy PA, Wurtele ES, Birt DF.

2007. Inhibition of PGE2 production by anti-inflammatory Hypericum perforatum Extracts and

Constituents in RAW264.7 Mouse Macrophage Cells. Journal of Agriculture and Food Chemistry.

55:7323-7331.

58. Zhai Z, Haney D, Wu L, Solco AK, Murphy PA, Wurtele ES, Kohut ML, Cunnick JE. 2007

Alcohol extracts of Echinacea inhibit production of NO and TNF-α by macrophages in vitro.

Journal of Food and Agricultural Immunology. 18: 221-236

59. Zhai Z, Liu Y, Wu L, Senchina DS, Wurtele ES, Murphy PA, Kohut ML, Cunnick JE. 2007

Enhancement of innate and adaptive immune functions by multiple Echinacea species. Journal of

Medicinal Food, 10(3): 423-434

60. Wurtele ES et al., MetNet: Systems Biology Tools for Arabidopsis. 2007. In Concepts in Plant

Metabolomics. Springer Verlag, 145-157.

61. Call AB, Hernnstadt S, Dickerson J, Wurtele ES, Bassham D. 2007. Virtual Cell: A Pedagogical

Convergence between Game Design and Science Education. Journal of Systemics, Cybernetics

and Informatics. 5:27-31.

62. Li Ling, Ilarslan HH, James MG, Myers AM, Wurtele ES. 2007. Genome wide co-expression

among the starch debranching enzyme genes AtISA1, AtISA2, and AtISA3 in Arabidopsis

thaliana. J Exp Bot. 58:3323-3342

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63. Cook D., Hofmann H., Nikolau B., Wurtele ES, Lee Eun-kyung, Yang H. 2007. Exploring gene

expressions using plots. J Data Science 5:151-181.

64. Kraus GA, J Bae J, Wu L, Wurtele ES. 2007. The synthesis and natural distribution of the major

ketone constituents in Echinacea pallida. Molecules 12, 406-414.

65. LaLone C, Hammer K, Wu L, Bae J, Layva N, Liu Y, Sia-Solco A, Kraus G, Murphy P, Wurtele

ES, Kim OK, Seo K, Widrlechner MP, Birt DF. 2007. Echinacea species and alkamides inhibit

prostaglandin E2 production in RAW264.7 mouse macrophage cells. J Agric Food Chem.

55:7314-7322.

66. Senchina DS, Wu L, Flinn GN, Konopka del N, McCoy JA, Widrelechner MP, Wurtele ES,

Kohut ML. 2006. Year-and-a-Half Old, Dried Echinacea Roots Retain Cytokine-Modulating

Capabilities in an in vitro Human Older Adult Model of Influenza Vaccination. Planta Med.

72:1440-1447.

67. Kraus GA, Bae J, Wu L, Wurtele ES. 2006. Synthesis and natural distribution of anti-

inflammatory alkamides from Echinacea. Molecules. 11, 758-767.

68. Lawrence M, Lee EK, Cook D, Hofmann H, and Eve Wurtele ES. 2006. exploRase: Exploratory

Data Analysis of Systems Biology Data. Fourth International Conference on Coordinated Multiple

Views in Exploratory Visualization (CMV'06). IEEE Computer Society. 14-20.

69. Yang Y, Wurtele ES, Cruz-Neira C, and Dickerson JA. 2006. Hierarchical visualization of

metabolic networks using virtual reality. In Proc. ACM Intl. Conf. on Virtual Reality Continuum

and Its Applications (Hong Kong, China). VRCIA '06. ACM Press, New York, NY, 377-381

70. Ding J, Hughes L, Berleant D, Fulmer A, Wurtele ES. 2006. PubMed Assistant: A Biologist-

Friendly Interface for Enhanced PubMed Search. Bioinformatics. 22: 378–380

71. Call, AB, Herrnstadt S, Dickerson J, Wurtele, ES and Bassham D. 2006. Virtual Cell: A

Pedagogical Convergence between Game Design and Science Education. SYSTEMICS,

CYBERNETICS AND INFORMATICS. 5:27-31

72. Yang Y, Engin L, Wurtele ES, Cruz-Neira C, Dickerson JA. 2005. Integration of metabolic

networks and gene expression in virtual reality. Bioinformatics. 21:3645-3650.

73. DeCook R, Nettleton D, Foster CM, Wurtele ES. Identifying differentially expressed genes in

unreplicated multiple-treatment microarray timecourse experiments. Computational statistics &

data analysis. 2005 ; 50:518-532.

74. Ding J, Viswanathan K, Berleant D, Hughes L, Wurtele ES, Ashlock D, Dickerson JA, Fulmer

A, Schnable PS, 2005. Using the Biological Taxonomy to Access Biological Literature with

PathBinderH, Bioinformatics. 21:2560-2562.

75. Fatland B, Nikolau BJ, Wurtele ES. 2005 . Reverse Genetic Characterization of Cytosolic Acetyl-

CoA Generation by ATP-citrate lyase in Arabidopsis. Plant Cell 17:182-203. epub 2004 Dec 17

76. Lee E-K, Cook D, Hofmann H, Wurtele ES, Kim D, Kim J, An H. 2004 GeneGobi : Visual Data

Analysis Tools For Microarray Data. COMPSTAT’2004 Symposium. Physica-Verlag/Springer

77. Du P, Gong J, Wurtele ES, Dickerson JA, Modeling Gene Expression Networks using Fuzzy

Logic. 2005 IEEE Trans. On Systems, Man and Cybernetics, Part B. 35:1351-1359

78. Jenkins H, Hardy N, Beckmann M, Draper J, Smith AR, Taylor J, Fiehn O, Goodacre R, Bino R,

Hall R, Kopka J, Lange BM, Liu JR, Mendes P, Nikolau BJ, Oliver SG, Paton NW, Roessner-

Tunali U, Saito K, Smedsgaard J, Sumner LW, Wurtele ES, Kell DB. 2004. A proposed

framework for the description of plant metabolomics experiments and their results. Nature

Biotech 22:1601-1606. (244 citations)

79. Bino RJ, Hall RD, Fiehn O, Kopka J, Saito K, Draper J, Nikolau BJ, Mendes P, Roessner-Tunali U,

Beale MH, Trethewey RN, Lange BM, Wurtele ES, Sumner LW. 2004. Potential of

metabolomics as a functional genomics tool. Trends Plant Sci. 9:418-425. (500 citations)

80. Wu L, Bae J, Kraus G, Wurtele ES. 2004. Diacetylenic isobutylamides of Echinacea: Synthesis

and natural distribution. Phytochemistry 65:2477-2484.

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81. Dickerson JD, Du P, Wurtele ES, Li J. 2004. Fuzzy modeling of metabolic maps in MetNetDB.

Fuzzy Information, 2004. NAFIPS 1:175-179

http://ieeexplore.ieee.org/xpl/abs_free.jsp?arNumber=1336272

82. Dickerson JA, Berleant DA, Du P, Ding J, Foster CM, Ling L, Wurtele ES. 2004. Using virtual

reality to understand complex metabolic networks. Atlantic Symposium Comp Biol Genomic Info

Systems Technol, 950-953.

83. Wurtele ES, Li J, Diao L , Zhang H, Foster CM, Fatland B, Dickerson JD, Cook D, Brown A,

Cox Z, Lee EK, Hofmann H. 2003. MetNet: software to build and model the biogenetic lattice of

Arabidopsis. Comp Funct Genomics. 4:239-245.

84. Che P, Weaver LM, Wurtele ES, Nikolau BJ. 2003. The role of biotin in regulating 3-

methylcrotonyl-CoA carboxylase expression in Arabidopsis. Plant Physiol 131: 1479-1486

85. Fatland BF, Ke J-S, Anderson M, Mentzen W, Cui LW, Allred C, Johnston JL, Nikolau BJ,

Wurtele ES 2002. Molecular Characterization of a Novel Heteromeric ATP-Citrate Lyase that

Generates Cytosolic Acetyl-CoA in Arabidopsis. Plant Physiol. 130:740-756.

86. Dickerson, JA, Berleant, D, Cox Z, Qi, W, Ashlock D, Fulmer AW, Wurtele ES. 2002 “Creating

and Modeling Metabolic and Regulatory Networks Using Text Mining and Expert Knowledge,” in

Computational Biology and Genome Informatics, edited by Cathy H. Wu, Paul Wang, Jason T. L.

Wang, World Scientific

87. Che P, Wurtele ES, Nikolau BJ. 2002 Metabolic and Environmental Regulation of 3-

Methylcrotonyl-CoA Carboxylase Expression in Arabidopsis. Plant Physiol 129:625-637

88. Ding J, Berleant D, Nettleton D, E. Wurtele ES. 2002. Mining Medline: Abstracts, sentences, or

phrases? Pacific Symposium on Biocomputing, 1-12. (224 citations)

89. Dickerson, JA, Cox Z, Wurtele ES, Fulmer AW. 2001. “Creating metabolic and regulatory

network models using fuzzy cognitive maps,” IFSA World Congress and 20th North American

Fuzzy Information Processing Society (NAFIPS) International Conference, Vancouver, British

Columbia, Volume 4, 2171-2176, July, 2001

90. McKean AL, Ke J-S, Song J, Achenbach S, Nikolau BJ, Wurtele ES. 2000. Molecular

characterization of the non-biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase. J Biol

Chem. 275, 5582-5590.

91. Ke J-S, Behal B, Yunkers S, Nikolau BJ, Wurtele ES, Oliver DJ. 2000. The role of pyruvate

dehydrogenase and acetyl-CoA synthetase in fatty acid synthesis in developing Arabidopsis seeds.

Plant Physiol 123:497-508

92. Ke J-S, Wen TN, Wurtele ES, Nikolau BJ. 2000. Coordinate regulation of the spatial and

temporal expression of the nuclear and chloroplastic encoded genes of the heteromeric acetyl-CoA

carboxylase. Plant Physiol 122: 1057-1071.

93. Guan X, Diez T, Prasad KT, Nikolau BJ, Wurtele ES. 1999. Discovery and characterization of

geranoyl-CoA carboxylase in plants. Archives Biochem Biophys 362:12-21

94. Caffrey JJ, Choi J-K, Wurtele ES, Nikolau BJ. 1998. Tissue distribution of acetyl-CoA

carboxylases in leaves of leek (Allium porrum L.). J Plant Physiol 153:265-269

95. Yanai Y, Kawasaki T, Shimada H, Wurtele ES, Nikolau BJ, Ichikawa N. 1995. Genomic

organization of 251 kDa acetyl-CoA carboxylase genes in Arabidopsis: tandem gene organization

has made two differentially expressed isozymes. Plant Cell Physiol 36:779-787

96. Anderson MD, Che P, Song J, Nikolau BJ, Wurtele ES. 1998. 3-Methylcrotonyl-CoA

carboxylase is a component of the mitochondrial leucine catabolic pathway in plants. Plant Physiol

118: 1127-1138

97. Ke J, Choi JK, Smith M, Horner HT, Nikolau BJ, Wurtele ES 1997. Structure of the CAC1 gene

and in situ characterization of its expression: The Arabidopsis thaliana gene coding for the biotin-

containing subunit of the plastidic acetyl-CoA carboxylase. Plant Physiol 113:357-365.

98. Calvo ES, Wurtele ES, Shoemaker RC. 1997. Cloning, mapping and analyses of expression of

the EM-like gene family in soybean [Glycine max (L). Merr.) Theor Appl Genet 94: 957-967

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99. Held BM, John I, Wang H-Q, Wurtele ES, Colbert JT. 1997. zrp2: a novel maize gene whose

mRNA accumulates in the root cortex and mature stems. Plant Mol Biol 94: 957-967

100. Sun J, Ke J, Johnson JL, Nikolau BJ, Wurtele ES 1997. Molecular cloning and characterization

of CAC2: The Arabidopsis thaliana gene coding for the biotin carboxylase subunit of the plastidic

acetyl-CoA carboxylase. Plant Physiol 115:1371-1383

101. Weaver LM, Lebrun L, Franklin A, Huang L, Hoffman N, Wurtele ES, Nikolau BJ. 1994.

Molecular cloning of the biotinylated subunit of 3-methylcrotonyl-CoA carboxylase of

Arabidopsis thaliana. Plant Physiol. 107: 1013-1014.

102. Weaver LM, Yu F, Wurtele ES, Nikolau BJ. 1996. Characterization of the cDNA and gene

coding for the biotin synthase of Arabidopsis thaliana. Plant Physiol 110:1021-1028

103. Eom J, Baker WR, Kintanar A, Wurtele ES. 1996. The embryo-specific EMB-1 protein of

Daucus carota is flexible and unstructured in solution. Plant Sci 115:17-24.

104. Guan X, Wurtele ES. 1996. Reduction of growth and acetyl-CoA carboxylase activity by

expression of a chimeric streptavidin gene in Escherichia coli. Appl Microbiol and Biotechnol

44:753-758.

105. Wang H-Q, Colbert JT, Wurtele ES. 1995. A molecular marker of the root cortical ground

meristem is present in both root and coleorhiza of the maize embryo. American Journal of Botany.

82:1083-1088.

106. Wang X, Wurtele ES, Nikolau BJ. 1995. Regulation of beta-methylcrotonyl-CoA carboxylase

activity by biotinylation of the apoenzyme. Plant Physiol. 108:1133-1139.

107. Choi J-K, Yu F, Wurtele ES Nikolau BJ. 1995. Molecular cloning and characterization of the

cDNA coding for the biotin-containing subunit of the chloroplastic acetyl-CoA carboxylase. Plant

Physiol 109:619-625.

108. Diez TA, Wurtele ES, Nikolau BJ. 1994. Purification and characterization of 3-methylcrotonyl-

CoA carboxylase from leaves of Zea mays. Arch Biochem Biophys. 310: 64-75.

109. Song J, Wurtele ES, Nikolau BJ. 1994. Molecular cloning and characterization of the cDNA

coding for the biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase: Identification of

the biotin carboxylase and biotin carrier domains. Proc Natl Acad Sci USA. 91: 5779-5783.

110. Wang X, Wurtele ES, Keller G, McKean AL, Nikolau BJ. 1994. Molecular cloning and

characterization of cDNAs and genes coding for beta-methylcrotonyl-CoA carboxylase of tomato.

J Biol Chem. 269: 11760-11769

111. Li, X, Wurtele ES, LaMotte CE. 1994. Identification of abscisic acid in liverworts.

Phytochemistry. 37:625-627

112. Liu L, Hammond EG, Wurtele ES. 1994. Accumulation of petroselinic acid in developing

somatic carrot embryos. Phytochemistry. 37: 749-753.

113. Wurtele ES, Wang H-Q, Dugarian S, Nikolau BJ, Ulrich TS. 1993. Isolation and expression of

a gene whose mRNA accumulates early in somatic embryo development. Plant Physiol. 102: 303-

312.

114. Held BM, Wang H-Q, John I, Wurtele E, Colbert JT. 1993. Isolation and characterization of a

maize root-preferentially expressed mRNA that may code for an O-methyl transferase of suberin

biosynthesis. Plant Physiol. 102: 1001-1008.

115. Chen Y, Wurtele ES, Wang X, Nikolau BJ. 1993. Purification and characterization of

methylcrotonyl-CoA carboxylase from carrot embryos. Arch Biochem Biophys. 305: 103-109.

116. Wurtele ES, Nikolau BJ. 1992. Differential accumulation of biotin enzymes during carrot

somatic embryogenesis. Plant Physiol. 99:1699-1703.

117. John I, Wang H-Q, Held BM, Wurtele ES, Colbert JT. 1992. An mRNA that specifically

accumulates in maize roots delineates a novel subset of developing cortical cells. Plant Mol Biol.

20: 821-831

118. Wurtele ES, Nikolau BJ. 1990. Plants contain multiple biotin enzymes: Discovery of 3-

methylcrotonyl-CoA carboxylase, propionyl-CoA carboxylase, and pyruvate carboxylase in the

plant kingdom. Arch Biochem Biophys. 278:179-186.

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119. Ulrich T H, Wurtele ES, Nikolau BJ. 1990. Sequence of an mRNA accumulating specifically in

carrot somatic embryogenesis. Nuc Acid Res. 18:2826.

120. Wurtele ES. 1989. Salt tolerance responses of callus cultures, microshoot cultures, and whole

plants of Atriplex canscens gigas. In E. D. McArthur and A. Wallace (eds.), Symposium on Shrub

Biotechnology and Ecophysiology. U.S. Department of Agriculture, Forest Service

121. Wurtele ES, Bulka K. 1989. A simple, efficient method for transformation of carrot callus

cells mediated by Agrobacterium tumefaciens. Plant Science 61:253-262.

122. Keller GL, Nikolau BJ, Ulrich TS, and Wurtele ES. 1988. Comparison of starch and ADP-

glucose pyrophosphorylase levels in non-embryogenic cells and developing embryos from induced

carrot cultures. Plant Physiol. 86:451-456.

123. King GJ, VA Turner, CE Hussey, ES Wurtele, and SM Lee. 1988. Isolation and

characterization of a tomato cDNA clone that codes for a salt induced protein. Plant Molec Biol.

10:401-412.

124. Wurtele ES, Keller G, Ulrich TH, Nikolau BJ. 1988. Quantitation of starch and ADP-glucose

pyrophosphorylase in non-embryogenic cells and embryogenic cell clusters from carrot suspension

cultures. J Plant Physiol. 132:683-689.

125. Nikolau BJ, Croxdale J, Ulrich TH, and Wurtele ES. 1987. Acetyl-CoA carboxylase and

biotin-containing proteins in carrot somatic embryogenesis. In Metabolism, Function and

Structure of Plant Lipids (P.K. Stumpf, J. B. Mudd, and W. D. Nes, eds.), Plenum Press, NY, pp.

517-519.

126. Wurtele ES, Young D, Garton S, Balandrin MF, McKell CM. 1987. Propagation of an elite,

high-biomass producing genotype of Atriplex canescens gigas by axillary enhancement. Biomass

12:281-291.

127. Wurtele ES, Nikolau BJ. 1986. Enzymes of glucose oxidation in leaf tissues: The distribution

of the enzymes of glycolysis and the oxidative pentose phosphate pathway between epidermal and

mesophyll tissues of C3-plants and epidermal, mesophyll and bundle sheath tissues of C4-plants.

Plant Physiol. 82:503-510.

128. Balandrin M, Klocke J, Wurtele ES, Bollinger H. 1985. Natural plant chemicals: Sources of

new industrial, medicinal, and agricultural materials. Science 7:1154-1160. (873 citations)

129. Nikolau BJ, Wurtele ES, and Stumpf PK. 1985. Use of streptavidin to detect biotin-containing

proteins in plants. Anal Biochem. 149:448-453.

130. Wurtele ES, Nikolau BJ, Conn EE. 1985. Subcellular and developmental distribution of ß-

cyanoalanine synthase in barley leaves. Plant Physiol. 78:285-290.

131. Nikolau BJ, Wurtele ES, and Stumpf PK. 1984. Subcellular distribution of acetyl-CoA

carboxylase in mesophyll cells of barley and sorghum leaves. Arch Biochem Biophys. 235:555-

561.

132. Nikolau BJ, Wurtele ES, Stumpf PK. 1984. Tissue distribution of acetyl-Coenzyme A

carboxylase in leaves. Plant Physiol. 75:895-901.

133. Wurtele ES, Nikolau BJ, Conn EE. 1984. The tissue distribution of ß-cyanoalanine synthase in

leaves. Plant Physiol. 75:979-982.

134. Wurtele ES, Thayer SS, Conn EE. 1983. Subcellular localization of UDP-glucose: aldehyde

cyanohydrin ß-glucosyl transferase in epidermal plastids of sorghum leaf blades. Plant Physiol.

70: l732-1734

135. Wurtele ES, Hedden P, Phinney BO. 1982. Metabolism of ent-karenoid gibberellin precursors

by a cell-free system from maize seedling shoots. J Plant Growth Reg. 1:15-24

WORKSHOPS (selected)

Texas Teachers Workshop. Day-long workshops on Meta!Blast. Judith Syrkin-Nikolau; Mandel

Mandijem 6/13. 6/14, 6/15

National NanoDays, Iowa Science Center. Wurtele ES, Bassham DB 4/13

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Symbi Science Days. Day-long workshops on Meta!Blast at at middle schools serving underrepresented students

in Des Moines, IA. Schneller W, Wurtele ES, Bassham DB. Six sessions in 2011/12

Meta!Blast cell video game. Road Less Traveled Conference for middle school and high school girls. Stenerson

M, Schneller W, Wurtele ES. Six sessions each year in 2010, 2011, 2012

Meta!Blast cell video game. IT-tech for high school students, Iowa State University. Langerkamp E, Kabala D,

Wurtele ES. 4/10

MetNet Systems biology tools. University of Florida, Gainsville, Florida Wurtele ES. 2/2008

Wurtele ES. Meta!Blast: a virtual metabolic cell, ASPB, Chicago, IL, Wurtele ES. 7/07

Medicinal Plants of the Southwest Summer Workshop. New Mexico State

University, NM, Wurtele ES. 6/07

Wurtele ES, Ling L, Lawrence M, Wu L, and Ransom N. MetNet. Exploration of experimental data from

Arabidopsis and soybean as a functional genomics tool. Iowa State University, Ames, IA, 5/14-16//07

Meta!Blast cell video game. Veishea Festival, Iowa State University. Wurtele ES, Kabala D, and others. 4/07

MetNet systems biology tools. Kansas State University, KS, Wurtele ES. 4/07

MetNet: MetaOmGraph, exploration of large data sets as a functional genomics tool. Giessen University,

Giessen, Germany Wurtele ES. 3/07

MetNet: MetaOmGraph. Exploration of large data sets as a functional genomics tool. Iowa State University,

Ames, IA, Wurtele ES, Babka H, Ransom N. 11/06

Echinacea for Native American Undergraduates http://www.lawrencelab.org/Outreach/2006/home.html , Iowa State

University, Ames, IA Wurtele ES, Wu L. 7/06

Meta!Blast: a virtual metabolic cell, 11th International Conference on Arabidopsis. Madison WI, Wurtele ES and

Bassham D. 6/06

Systems Biology Tools, 11th International Conference on Arabidopsis. Madison WI, Wurtele ES. 6/06

INVITED Speaker (selected, since 2000)

Wurtele ES. Grand Rounds Seminar, Mayo Clinic, Rochester. F/14

Wurtele ES. Advanced Study Group, “Co-evolution: A proving ground for non-equilibrium statistical

mechanics“. Max Planck Institute for the Physics of Complex Systems, Dresden. F/14

Wurtele ES. Plenary speaker. International Confererence of the Korean Society for Mass Spectrometry.

S/14

Wurtele ES. International Workshops on New Achievements in Plant Science. Institute of Plant

Physiology, Moscow; Biology Department of the S.Petersbourg University. S/14

Wurtele ES. Plenary speaker. Florida Genetics Symposium 2014. Florida University. Sp/14

Wurtele ES. Seminar Series of the Institute of Biological Chemistry (IBC), Washington State

University. F/13

Wurtele ES. Plants and People Conference, Max Planck Institute of Molecular Plant Physiology, S/13

Wurtele ES, A Shah. Meta!Blast: A technology-enabled interactive computer game for

museums with a built-in evaluation component. International Conference on Museums, Rio De Janiero

S/13

Wurtele, ES. Plant Biological Sciences Seminar Series, University of Minnesota, 2/12

Wurtele, ES. Meta!Blast computer game: a pipeline from science to 3D art to education. The

Engineering Reality of Virtual Reality, Interenational Society for Optics and Photonics, San Francisco,

CA 1/12

Wurtele, ES. Science Centre, Mumbai, India 12/10

Wurtele, ES. Regional Science Centre, Guwahati, Assam, India 12/10

Wurtele, ES. Nehru Science Centre Mumbai, India 12/10

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Wurtele, ES. Birla Industrial & Technological Museum, Kolkata (Headquarters), India 12/10

Wurtele, ES. Biotechnology Gallery, Visvesvaraya Industrial & Technological Museum, Bangalore,

India 12/10

Wurtele ES. Systems approach to metabolism and its regulation. Michigan State University. 8/10

Wurtele ES, Li L, Sen T. Phytochemistry and American Society of Pharmacognosy Meeting. Searching

the transcriptomic space to decipher metabolism and its regulation. 7/10

Wurtele, ES. MetaBlast, Birla Science Center, Hyderabad, India 11/09

Wurtele, ES. Regulation of metabolic networks. Somani Institute, Mumbai, India 11/09

Wurtele ES. Molecular network of fatty acid metabolism and regulation. Gordon Conference on Plant

Lipids. Galveston, TX. 2/09

Wurtele ES. Metabolomics approaches to characterize the constituents of soy-based fish feed, and

determine evaluate which constituents are detrimental to the fish. USDA/NOAH session.World

Aquaculture Conference. Seattle, WA. 2/09

Wurtele ES. Effects of constituents of medicinal plants Echinacea and Hypericum on pain and

inflamation related signaling in animal models. Purdue/NIH 7/08

Wurtele ES. Exploration of the Arabidopsis metabolic and regulatory network: a novel gene regulating

composition. 2/08 University of Florida, Gainsville, Florida

Wurtele ES. "Regulation of Metabolism”. (Speaker and Session Chair). American Society for Plant

Biology, Chicago, 7/07

Wurtele ES. Meta!Blast: a virtual metabolic cell, Education and Outreach Special Session. American

Society for Plant Biology, Chicago, 7/07

Wurtele ES. Exploring metabolic and regulatory networks. KU Functional Genomics Consortium

Symposium, Kansas State University 4/07

Wurtele ES. MetNet Systems Biology: Exploration of the metabolic and regulatory network of plants. III

International Rauischholzhausen Conference, Analysis of Compatibility Pathways in Plant-Microbe-

Interactions. Giessen, Germany 3/07

Wurtele ES, The MetNet Platform: Bioinformatics Tools to Explore Systems Biology. IPPM graduate

students invited speaker.

Wurtele ES, Global regulatory and metabolic networks in Arabidopsis. Sixth Annual Bioinformatics

Symposium. Ames IA 7/06

Wurtele ES, Metabolomics and systems biology. Fourth International Congress on Plant Metabolomics,

Rothemstad, England. 6/06

Wurtele ES. Workshop on MetNet computational platform. Plant and Animal Genomics. San Diego, CA,

1/06

Wurtele ES. Metabolomics and genetics of the medicinal genera Echinacea. Plant and Animal

Genomics. San Diego, CA, 1/06

Wurtele ES. The MetNet platform: bioinformatics tools to explore systems biology. GDCB brown bag,

ISU 9/05

Wurtele ES. A computational platform to explore the starch metabolic network. Biosynthesis and

Degradation of Reserve Carbohydrates in Plants. University of Bern, Switzerland. 9/05

Wurtele ES, Diane Birt. Echinacea and Hypericum. NIH Botanical Centers, Bethesda MD. 8/05

Wurtele ES, Model Legume Conference, National Science Foundation, Asilomar CA, 5/05

Wurtele ES, Exploring metabolic and regulatory networks. Computational Biology Seminar Series,

Michigan State University MN. 8/04

Wurtele ES. Integration of microarray, metabolomics, and metabolic flux in developing soybean seeds

US Soybean Conference. St Louis MO. 4/04

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Wurtele ES. A systems biology approach to metabolic networking in Arabidopsis. Third International

Congress on Plant Metabolomics, ISU. Ames IA. 6/04

Wurtele ES. Tools to elucidate metabolic networking in plants. Computational Biology Seminar Series,

MSU. East Lansing MI. 5/04

Wurtele ES. Software for computational analysis of metabolic networking in plants. Department of Plant

Biology, Hebrew University, Rehovot Campus, Israel. 4/04

Wurtele ES. METNET: Integration of metabolomic, proteomic and transcriptomic gene expression data.

UI/ISU Bioinformatics Workshop. University of Iowa, IA. 5/03.

Wurtele ES. METNET: software to build and model the biogenetic lattice of Arabidopsis. Department of

Biology, University of Iowa, IA. 4/03

Wurtele ES. Developing tools to dissect the metabolic and regulatory lattice of Arabidopsis. Plant and

Animal Genomics, San Diego, CA. 1/03

Wurtele ES Dissecting the metabolic and regulatory network of Arabidopsis. Metabolic Engineering IV-

Tuscany, Italy 10/02

Wurtele ES. The metabolic and regulatory network of Arabidopsis. Plenary lecture. Midwest

Photosynthesis Conference, IN 11/02

Wurtele ES. Developing new software to analyze global metabolome, proteome, and transcriptome

expression data in Arabidopsis. Plant Science Institute Symposium: Plant Proteomes: Structures,

Changes, Interactions and Functions. Ames, IA 6/02

Wurtele ES, Dickerson JA, Cox Z, Cook D, Ashlock D, Berleant D, Fatland B, Foster CM. 2002

Computational analysis of genome-wide metabolome, proteome, and transcriptome expression data in

Arabidopsis. First International Congress on Plant Metabolomics. 7-11 April, 2002 Wageningen, The

Netherlands

Wurtele, ES. 2001. ""Weaving the web of acetyl-CoA metabolism: Dissecting the interconnection

between primary and secondary metabolism in the post-genomic era". National Science Foundation:

Biological Sciences Seminar Series

PATENTS

Colbert JT, Wurtele ES, Held BM, Paul Dietrich. 1997. Root Preferential Promoter. U.S. patent #

5,633,363

Nikolau B, Wurtele ES, Choi J-K. 1998. Transcriptional promoter of the CAC1 gene of the Arabidopsis

thaliana heteromeric acetyl-CoA carboxylase. Pending #60/091,386

Nikolau B, Wurtele ES, David J. Oliver, Robert Behal, Patrick S. Schnable, Jinshan Ke, Jerry L.

Johnson, Carolyn C. Allred, Beth Fatland, Isabelle Lutziger and Tsui-Jung Wen. 2004 "Materials

and Methods for the Alteration of Enzyme and Acetyl CoA Levels in Plants. #6,764,851

Nikolau B; Jin Y, McMullen K, Wurtele ES Yu X. 2007 MATERIALS AND METHODS FOR

EXPRESSING BRANCHED CHAIN FATTY ACIDS (BCFA) IN ORGANISMS ISURF# 03386

pending

Hillwig ML, Wurtele ES. 2010. ANTI-INFLAMMATORY AND ANTI-HIV COMPOSITIONS AND

METHODS OF USE. #7,854,946

http://www.techtransfer.iastate.edu/en/for_industry/technology_search/search.cfm?fuseaction=techn

ology.details&id=3460

Li, Ling, Wurtele ES, 2012. MATERIALS AND METHODS FOR MODIFYING A BIOCHEMICAL

COMPONENT IN A PLANT. #20120222167 [QQS gene]

Li Ling, Wurtele ES. Feb, 2015. INCREASING PROTEIN CONTENT BY MODIFYING

TRANSCRIPTIONAL REPRESSOR BINDING SITE IN NF-YC4 PROMOTER. #62/117,924.

(pending application)

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Hur, Manhoi, Wurtele ES. 2014. A novel systems resource for big data.

RESEARCH FUNDING (since 2008):

National Science Foundation I-CORPS Team $50,000

Wurtele (PI), co team members Schneller, Adamowski.

Substrate Games LLC: Learning and engagement through computer games.

10/15-3/16

Department of Energy FOA-0001192 $1,799,950

Nikolau (PI), Wurtele and 3 other co-PIs

Integrated and dynamic multi-spectroscopic in situ imaging of plant metabolism at the level of subcellular

compartments

8/2015 - 7/2018

NSF Engineering Research Center for Biorenewable Chemicals. EEC-0813570 subaward $300,683

Co-PIs Wurtele, Campbell, Nikolau.

Lets pump it up: Genetics informatics and experimental laboratory.

8/2014- 8/2016

NSF Engineering Research Center for Biorenewable Chemicals. EEC-0813570 $26,000,000

Shanks, Director. Nikolau, Deputy Director, Multiple PIs.

8/2008 - 8/2018 ($125,000/year to ESW)

LASCAC , LASCAC, College Liberal Arts Sciences, Iowa State University $41,300

Wurtele and Multiple Pis

MetaBlast interactive application for undergraduate teaching and learning of

complex science concepts

12/2011-11/2012

United Soybean Board: High Protein Soy $299,015

Li (PI), Wurtele cooperator

9/2011-12/2013

National Science Foundation MCB-0951170 $920,000

Uncovering novel signaling interactions in plant metabolic networks.

Wurtele (PI), Li, Sen.

4/2010-3/2015

National Institutes of Health: National Institute of General Medical Sciences. NIGM-99511 $6,500,000

Advancing Drug Development from Medicinal Plants Using Transcriptomics and Metabolomics.

Chappell (PD), 3 coPIs, subcontract to Wurtele, Iowa State University ($740,406 sub)

10/09-9/12

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Department of Energy- ARPA-E $5,466,692

A Genetically Tractable Microalgal-based Platform for Advanced Biofuel Production.

Spalding (PI), Oliver, Halverson, Nikolau, Wurtele

10/10-9/12

National Institutes of Health: SEPA R25RR025147 $1,125,000

Meta!Blast: Meta!Blast: A 3D cell and metabolic biology interactive learning environment Wurtele (PI),

Diane Bassham, Adah Ackerman

9/08-4/14

National Science Foundation MCB-0820823 $1,412,500

Metabolomics: A functional genomics tool for deciphering functions of

Arabidopsis genes in the context of metabolic and regulatory networks

Nikolau (PI), CoPIs Wurtele and 13 others

9/09-8/13

National Institutes of Health NIEHS-1 P01 ES1 2020-01 $5,160,000

Center for Research on Dietary Supplements

Diane Birt (Director and PI), Wurtele (co-Director and PI)

7/07-6/10

National Science Foundation SEI+II BIO-IIS0612240 $875,250

Interactive Visualization and Analysis of Large-Scale Graphs for Biological Network Modeling

Dickerson (PI), Wurtele, Reiners

9/06-8/10

National Science Foundation DBI 0520267 $969,634

MetNet: Integrated Software for Arabidopsis Systems Biology

Wurtele (PI), Berleant, Cook, Dickerson, Miller

9/05-8/08