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96 RACHITOGENIC EFFECT O:F YEAST FOR PIGS Pig 3148 showed severe rickets after 16 weeks on the high yeast diet. When first given calciferol this pig had to be hand fed with a half-and-half mixture of the yeast diet and diet 1 since it refused to eat the yeast diet alone. After only eight days' treatment the animal was able to rise and feed from the trough and readily consumed the original yeast mixture. At the end of six weeks' treatment the pig was clinically normal and was slaughtered. SUMMARY The results are in general agreement with those of our previous work. The rachitic nature of the changes produced by feeding a 20 per cent. yeast diet has been confirmed. Rickets was prevented by addition to the yeast diet of either cod liver oil or calciferol (1190 i.u. of vitamin D per day) and was rapidly cured by larger doses of calciferol: it was almost completely prevented by addi- tion of 4 per cent. of calcium carbonate. When 6 per cent. sodium phosphate (Na 2 HP0 4 12 H 2 0) was added to anormal diet containing meat and bone meal, rickets failed to develop, but three of six pigs died after two to three weeks with gastro-enteritis. The survivors showed no evidence of rickets and it thus appears that the rachitogenic effect of yeast is not due merely to its .high content of available phosphorus. The exact rnechanism of the production of rickets in pigs on a high yeast diet remains unknown. ACKNOWLEDGMENTS The authors are again indebted to all those who helped with the previous experiments and to whom acknowledgment was then made (Braude, Kon and White, 1943). REFERENCE Braude, R., Kon, S. K., and White, E. G. (1943). J. comp. Path., 53, 161. [Received for publication June 29th, 1943] Errata. Braude, Kon and White (1943), J. comp. Path., 53, 161. p.162. Fig.6. Fig.8. Table IV. 15th line from bottom. Insert after " ... flaked maize," " 10 parts of meat meal, ... " For " (as Fig. 7) " read " (as Fig. 5)." For " to compare with Fig. 9," read " to compare with Fig. 7." Footnote. For" 'fable III " read " Table 11."

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96 RACHITOGENIC EFFECT O:F YEAST FOR PIGS

Pig 3148 showed severe rickets after 16 weeks on the high yeast diet. When first given calciferol this pig had to be hand fed with a half-and-half mixture of the yeast diet and diet 1 since it refused to eat the yeast diet alone. After only eight days' treatment the animal was able to rise and feed from the trough and readily consumed the original yeast mixture. At the end of six weeks' treatment the pig was clinically normal and was slaughtered.

SUMMARY

The results are in general agreement with those of our previous work. The rachitic nature of the changes produced by feeding a 20 per cent. yeast diet has been confirmed. Rickets was prevented by addition to the yeast diet of either cod liver oil or calciferol (1190 i.u. of vitamin D per day) and was rapidly cured by larger doses of calciferol: it was almost completely prevented by addi­tion of 4 per cent. of calcium carbonate. When 6 per cent. sodium phosphate (Na 2HP04 • 12 H 20) was added to anormal diet containing meat and bone meal, rickets failed to develop, but three of six pigs died after two to three weeks with gastro-enteritis. The survivors showed no evidence of rickets and it thus appears that the rachitogenic effect of yeast is not due merely to its .high content of available phosphorus. The exact rnechanism of the production of rickets in pigs on a high yeast diet remains unknown.

ACKNOWLEDGMENTS

The authors are again indebted to all those who helped with the previous experiments and to whom acknowledgment was then made (Braude, Kon and White, 1943).

REFERENCE

Braude, R., Kon, S. K., and White, E. G. (1943). J. comp. Path., 53, 161.

[Received for publication June 29th, 1943]

Errata. Braude, Kon and White (1943), J. comp. Path., 53, 161.

p.162.

Fig.6. Fig.8. Table IV.

15th line from bottom. Insert after " ... flaked maize," " 10 parts of meat meal, ... "

For " (as Fig. 7) " read " (as Fig. 5)." For " to compare with Fig. 9," read " to compare with Fig. 7." Footnote. For" 'fable III " read " Table 11."