ENTISEUROPEAN NETWORK OF TERATOLOGY INFORMATION SERVICES

27th Conference of the European Network of

Teratology Information ServicesBerlin, June 4-5, 2016

SCIENTIFIC PROGRAMME

ENTISEUROPEAN NETWORK OF TERATOLOGY INFORMATION SERVICES

27th Conference of the European Network of Teratology Information Services (ENTIS)

June 4-5, 2016 Charité University Medicine, Campus Virchow Klinikum (CVK), Berlin, Germany

Postal address: Augustenburger Platz 1; 13353 Berlin

Saturday, June 4 8.30 – 11.30 Board, Scientific Committee and Website Committee meetings at Embryotox institute

on Campus Virchow Klinikum, (internal address: Südring 3b) (lunch from 11.45 -12.30)

For all others: lunch on your own 12.45 Begin of the conference at Forum 3/Lehrgebäude, Kursraum 3 (2nd floor) 12.45 – 13.00 Welcome (Christof Schaefer & Corinna Weber-Schoendorfer, Berlin, Germany) 13.00 – 14.30 Scientific part 1 Moderators Asher, Ornoy, Jerusalem, Israel & Lavinia Schuler, Porto Alegre, Brasil

13.00 13.30 Defining the Zika virus embryopathy phenotype (Lavinia Schuler-Faccini, Porto Alegre, Brasil)

13.30 14.00 Zika virus – epidemiology, immunity, diagnostic tests (Jonas Schmidt-Chanasit, Hamburg, Germany)

14.00 - 14.30 Cytomegalic inclusion disease and pregnancy (Klaus Hamprecht, Tubingen, Germany) 14.30 – 15.00 Coffee break 15.00 – 18.00 business meeting 19.00 ENTIS dinner at Humboldt University Casino “Cum Laude” Sunday, June 5 8.30 – 9.45 Free communication, Part 1 (10 minutes each plus 5 minutes discussion) Moderators Ursula Winterfeld (Lausanne, Swiss) & Yusuf Cem Kaplan (Izmir, Turkey)

Tocilizumab use in pregnancy: Analysis of a Global Safety Database including data from clinical trials and post-marketing data (Maria Hoeltzenbein, Berlin, Germany)

The necessity of therapeutic levetiracetam (Keppra®) monitoring during pregnancy: A prospective study (Dotan Shaniv, Zerifen, Israel)

Collaborative ENTIS study of the fetal effects of maternal varenicline use in pregnancy (Jonathan L Richardson, Newcastle, United Kingdom)

Prenatal selective serotonin reuptake inhibitor use and risk of autism spectrum disorder in the children: A systematic review and meta-analysis (Yusuf C. Kaplan, Izmir, Turkey)

Risk increase of spontaneous abortion associated with maternal phenprocoumon therapy depends on time of treatment discontinuation during first trimester (Eleanor Hüttel, Berlin, Germany)

9.45 – 10.15 Poster Session and Coffee break 10.15 - 11.30 Free communication Part 2 (10 minutes each plus 5 minutes discussion) Moderators Alessandra Pistelli (Florence, Italy) & Matitiahu Berkovitch (Zerifen, Israel)

Consequences and treatment of nausea and vomiting during pregnancy - a cross-sectional study of 712 Norwegian women (Kristine Heitmann, Oslo, Norwegen)

Who seeks Teratology Information Service’s advice? A Germany-based evaluation of representativeness by socioeconomic indicators (Evelin Beck, Berlin, Germany)

Anogenital distance as a marker of reproductive toxicity (Revital Sheinberg, Zerifen, Israel)

Opipramol for antidepressant therapy in early pregnancy (Wolfgang E. Paulus, Ravensburg, Germany)

Pregnancy outcomes following thiocolchicoside exposure: Preliminary results of 48 cases (Fatih Akyol, Izmir, Turkey)

11.30 - 12.00 Poster Session and Coffee break 12.00 - 13.00 Scientific part 2 Moderators Herbert Juch (Graz, Austria) & Heli Malm, Helsinki, Finland 12.00 - 12.20 An alternative approach to birth defect assignment in clinical teratology. (Christof

Schaefer, Berlin, Germany) 12.20 - 12.40 Shall we ignore minor birth defects and variations in ENTIS studies? (Stephanie

Padberg, Berlin, Germany) 12.40 - 13.00 Consideration of genetic and pathogenetic aspects in birth defect interpretation

(Katarina Dathe, Berlin, Germany) 13.00 – 14.00 Lunch 14.00 Official end of the ENTIS conference 14.30 – 16.00 Tea round on methodological issues of ENTIS studies Moderator Reinhard Meister (Berlin, Germany) Examples: Inclusion and exclusion criteria for comparison groups including disease comparison cohorts, statistical challenges, classification of birth defects, study population and selection bias.