endovascular treatment of abdominal aortic aneurysms: an innovation in evolution and under...

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the forces promoting the rapid adoption of EVAR by sur- geons and others—namely, the excitement of being involved in a new procedure, the hype, the desire to obtain personal and institutional prestige, and financial gains for surgeons and device manufacturers. Within the context of their review, most of their points are correct, and surgeons using EVAR should pay them heed. We agree that EVAR should not generally be used to treat AAAs <5.5 cm in diameter unless the AAA is clearly enlarging, tender, or present in a small woman. EVAR should still be considered investigational and under evaluation and some form of audited follow-up for the life of all patients is mandatory. Prospective, randomized trials comparing EVAR with open AAA repair are justified in standard risk patients. In unfit, high-risk patients, EVAR should be compared in a randomized trial with best non- operative management. Such trials are underway in the United Kingdom, the United States, and the Netherlands, although only in the United Kingdom is a high-risk trial planned. These trials, which will establish accurate indica- tions for EVAR, should be supported. However, we cannot accept the editorial’s conclusion that EVAR is “a failed experiment.” This conclusion would suggest the abandonment of EVAR, which would be a mistake. The history of surgical innovation is based on progress through the development of new technology, application of surgical intuition to perfect a procedure, and selection of appropriate patients. Just because an innovation is new or imperfect or has risks does not mean it should be abandoned. Airplanes, jet engines, blood transfusions, and other innovations had early problems, yet all eventually proved advantageous. EVAR will eventu- ally prove to have value in selected (but not all) patients. Better devices and improved patient selection will almost certainly lead to improved results. Thus, EVAR is certainly here to stay, even though its precise role remains to be defined. EVAR is not a failed experiment; it is an innova- tion in evolution and under evaluation. REFERENCES 1. Collin J, Murie JA. Endovascular treatment of abdominal aortic aneurysm: a failed experiment. Brit J Surg 2001;88:1281-2. A recent editorial in the British Journal of Surgery, entitled “Endovascular treatment of abdominal aortic aneurysm: A failed experiment,” makes some worthy points but overlooks how surgical developments evolve. 1 It should be required reading for all vascular surgeons and others engaged in endovascular aneurysm repair (EVAR) and particularly for those performing EVAR in patients with small abdominal aortic aneurysms (AAAs) <5.5 cm in maximal diameter. The authors of the editorial, J. Collin and J. A. Murie, correctly point out the low rupture rate of small AAAs (<1% per year) and comment on the uncertain rupture rate of large AAAs. They also note the increasing device and procedural failures with time, the modification or with- drawal of all proprietary stent-grafts used in EVAR, the preponderance of small AAAs in most EVAR series, and the glaring lack of universal follow-up and audited reporting of late results. They indicate that the smaller AAAs that are usually treated by EVAR are those that may be easiest to repair by conventional open surgery and that this group of patients would have a low open-surgery operative mortal- ity and require fewer reinterventions than with EVAR. They summarize the appreciable early and late complica- tion rates of EVAR, the reintervention and conversion rates and the relatively high morbidity associated with some of these secondary interventions. They provide some evi- dence that EVAR may be more costly than conventional open AAA repair. They also note that the rupture risk of 1% per year after EVAR is not greatly different from the nat- ural history of most of the small AAAs so treated. They comment on the high 30-day and 1-year mortality rates when EVAR is employed. They conclude by enumerating 183 From Montefiore Medical Center/Albert Einstein College of Medicine a and the Department of Surgery, Toronto General Hospital, University of Toronto. b Competition of interest: nil. Reprint requests: Frank J. Veith, MD, Montefiore Medical Center, 111 East 210th St, New York, NY 10467 (e-mail: [email protected]). J Vasc Surg 2002;35:183. Copyright © 2002 by The Society for Vascular Surgery and The American Association for Vascular Surgery. 0741-5214/2002/$35.00 + 0 24/39/121639 doi:10.1067/mva.2002.121639 EDITORIAL Endovascular treatment of abdominal aortic aneurysms: An innovation in evolution and under evaluation Frank J. Veith, MD, a and K. Wayne Johnston, MD, FRCS(C), b New York, NY; and Toronto, Canada

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Page 1: Endovascular treatment of abdominal aortic aneurysms: An innovation in evolution and under evaluation

the forces promoting the rapid adoption of EVAR by sur-geons and others—namely, the excitement of beinginvolved in a new procedure, the hype, the desire to obtainpersonal and institutional prestige, and financial gains forsurgeons and device manufacturers.

Within the context of their review, most of their pointsare correct, and surgeons using EVAR should pay themheed. We agree that EVAR should not generally be usedto treat AAAs <5.5 cm in diameter unless the AAA isclearly enlarging, tender, or present in a small woman.EVAR should still be considered investigational and underevaluation and some form of audited follow-up for the lifeof all patients is mandatory. Prospective, randomized trialscomparing EVAR with open AAA repair are justified instandard risk patients. In unfit, high-risk patients, EVARshould be compared in a randomized trial with best non-operative management. Such trials are underway in theUnited Kingdom, the United States, and the Netherlands,although only in the United Kingdom is a high-risk trialplanned. These trials, which will establish accurate indica-tions for EVAR, should be supported.

However, we cannot accept the editorial’s conclusionthat EVAR is “a failed experiment.” This conclusionwould suggest the abandonment of EVAR, which wouldbe a mistake. The history of surgical innovation is basedon progress through the development of new technology,application of surgical intuition to perfect a procedure,and selection of appropriate patients. Just because aninnovation is new or imperfect or has risks does not meanit should be abandoned. Airplanes, jet engines, bloodtransfusions, and other innovations had early problems,yet all eventually proved advantageous. EVAR will eventu-ally prove to have value in selected (but not all) patients.Better devices and improved patient selection will almostcertainly lead to improved results. Thus, EVAR is certainlyhere to stay, even though its precise role remains to bedefined. EVAR is not a failed experiment; it is an innova-tion in evolution and under evaluation.

REFERENCES1. Collin J, Murie JA. Endovascular treatment of abdominal aortic

aneurysm: a failed experiment. Brit J Surg 2001;88:1281-2.

A recent editorial in the British Journal of Surgery,entitled “Endovascular treatment of abdominal aorticaneurysm: A failed experiment,” makes some worthypoints but overlooks how surgical developments evolve.1It should be required reading for all vascular surgeons andothers engaged in endovascular aneurysm repair (EVAR)and particularly for those performing EVAR in patientswith small abdominal aortic aneurysms (AAAs) <5.5 cm inmaximal diameter.

The authors of the editorial, J. Collin and J. A. Murie,correctly point out the low rupture rate of small AAAs(<1% per year) and comment on the uncertain rupture rateof large AAAs. They also note the increasing device andprocedural failures with time, the modification or with-drawal of all proprietary stent-grafts used in EVAR, thepreponderance of small AAAs in most EVAR series, and theglaring lack of universal follow-up and audited reporting oflate results. They indicate that the smaller AAAs that areusually treated by EVAR are those that may be easiest torepair by conventional open surgery and that this group ofpatients would have a low open-surgery operative mortal-ity and require fewer reinterventions than with EVAR.They summarize the appreciable early and late complica-tion rates of EVAR, the reintervention and conversion ratesand the relatively high morbidity associated with some ofthese secondary interventions. They provide some evi-dence that EVAR may be more costly than conventionalopen AAA repair. They also note that the rupture risk of 1%per year after EVAR is not greatly different from the nat-ural history of most of the small AAAs so treated. Theycomment on the high 30-day and 1-year mortality rateswhen EVAR is employed. They conclude by enumerating

183

From Montefiore Medical Center/Albert Einstein College of Medicinea

and the Department of Surgery, Toronto General Hospital, Universityof Toronto.b

Competition of interest: nil.Reprint requests: Frank J. Veith, MD, Montefiore Medical Center, 111

East 210th St, New York, NY 10467 (e-mail: [email protected]).J Vasc Surg 2002;35:183.Copyright © 2002 by The Society for Vascular Surgery and The American

Association for Vascular Surgery.0741-5214/2002/$35.00 + 0 24/39/121639doi:10.1067/mva.2002.121639

EDITORIAL

Endovascular treatment of abdominal aorticaneurysms: An innovation in evolution andunder evaluationFrank J. Veith, MD,a and K. Wayne Johnston, MD, FRCS(C),b New York, NY; and Toronto, Canada