endovascular aneurysm repair ( evar)

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Endovascular aneurysm repair (EVAR) Dr Ranjith MP Senior Resident Department of Cardiology Government Medical college Kozhikode

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Endovascular aneurysm repair ( EVAR) . Dr Ranjith MP Senior Resident Department of Cardiology Government Medical college Kozhikode. Introduction. Endovascular aneurysm repair (EVAR) is a relatively new method of treating aortic aneurysms - PowerPoint PPT Presentation

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Page 1: Endovascular aneurysm  repair ( EVAR)

Endovascular aneurysm repair (EVAR)

Dr Ranjith MPSenior Resident

Department of CardiologyGovernment Medical college

Kozhikode

Page 2: Endovascular aneurysm  repair ( EVAR)

Introduction

Endovascular aneurysm repair (EVAR) is a relatively new method of treating aortic aneurysms

Performed by inserting graft components folded and compressed within a delivery sheath through the lumen of an access vessel, usually the common femoral artery

Upon deployment, the endograft expands, contacting the vessel wall proximally and distally to exclude the aortic aneurysm sac from aortic blood flow and pressure

Page 3: Endovascular aneurysm  repair ( EVAR)

Introduction

The main advantages over open repair are

Avoidance of long incisions in the thorax or abdomen No cross-clamping of the aorta Less blood loss Lower incidence of visceral, renal, and spinal cord ischemia Less peri-operative mortality Earlier return to normal activity

Page 4: Endovascular aneurysm  repair ( EVAR)

Indications for repair

Abdominal aortic aneurysm : Symptomatic (tenderness or abdominal or back pain,

evidence for embolization, rupture)AAA Aneurysm size ≥5.5 cm AAA that has expanded by more than 0.5 cm within a six-

month interval

Thoracic aortic aneurysm Width >6 cm rapidly enlarging diameter (>5 mm of growth over 6m) symptoms such as chest pain, and diagnosis of aortic

rupture or dissection

Page 5: Endovascular aneurysm  repair ( EVAR)

1. Endovascular repair of abdominal aortic aneurysm

2. Thoracic endovascular aneurysm repair (TEVAR)

Page 6: Endovascular aneurysm  repair ( EVAR)

Endovascular repair of abdominal aortic aneurysm

Page 7: Endovascular aneurysm  repair ( EVAR)

Anatomic considerations

Page 8: Endovascular aneurysm  repair ( EVAR)

Anatomic considerations

Abdominal aorta is the most common site of arterial aneurysm

Defined as aneurysmal - diameter of the dilated region is increased more than 50 percent relative to normal aortic diameter

The normal diameter of the aorta at the level of the renal arteries is approximately 2.0 cm (1.4 to 3.0 cm)

An aortic diameter greater than 3.0 cm - aneurysmal

Page 9: Endovascular aneurysm  repair ( EVAR)

Anatomic considerations

Infrarenal – originates below the renal arteries

Juxtarenal – originates at the level of the renal arteries

Suprarenal – originates above the renal arteries

AAAs most often occur in the segment of aorta between the renal and IMA

Page 10: Endovascular aneurysm  repair ( EVAR)

Anatomic considerations

Approximately 5 percent involve the renal or visceral arteries

Up to 40 percent of AAAs are associated with iliac artery aneurysm

Majority of endovascular aneurysm repairs are performed on aneurysms affecting the infrarenal aorta and iliac arteries

Page 11: Endovascular aneurysm  repair ( EVAR)

Preoperative planningAortoiliac imaging

Needed to define the anatomy, determine the feasibility of endovascular repair, and choose the size and configuration of endograft components

CT angiography with 3-D reconstruction preferred

2D CT- aortic diameter measurements will be overestimated if the aorta is angulated and the longitudinal axis is not perpendicular to the imaging plane

Page 12: Endovascular aneurysm  repair ( EVAR)

Preoperative planningAortoiliac imaging

The use of DSA is limited - cannot evaluate the true lumen diameter, extent of thrombus, plaque, or degree of calcification

MR angiography can be used but gadolinium administration in the setting of renal dysfunction is a relative contraindication

MRA fails to depict vessel wall calcification, which has implications for vascular access

Page 13: Endovascular aneurysm  repair ( EVAR)

MeasurementsAortic neck diameter

Aortic diameter at the lowest renal artery

The required endograft diameter = 15 to 20% more of measured aortic neck diameter

Over-sizing the endograft 15 to 20% provide sufficient radial force to prevent device migration

Page 14: Endovascular aneurysm  repair ( EVAR)

MeasurementsAortic neck diameter

Devices up to 36mm diameter are available

Over-sizing may lead to kinking of the device, which can form a nidus for thrombus formation or endoleak

Over-sizing may result in incomplete expansion of the endograft with infolding & inadequate seal, and can also be associated with intermediate and long-term neck expansion

Under sizing- inadequate seal

Page 15: Endovascular aneurysm  repair ( EVAR)

Conical/reverse tapered aortic neck

A conical neck is present when the diameter of the aorta 15 mm below the lowest renal artery is ≥10 percent larger than the diameter of the aorta at the lowest renal artery

Potential Solutions Rejection Oversizing Supra-renal Fixation Balloon-expandable Stent Fenestrated or Branched Endograft

Page 16: Endovascular aneurysm  repair ( EVAR)

MeasurementsAortic neck length

The distance from the lowest renal artery to the origin of the aneurysm

Should be at least 10 to 15 mm to provide an adequate proximal landing zone for endograft fixation

Page 17: Endovascular aneurysm  repair ( EVAR)

MeasurementsAortic neck angulation

The angle formed between points connecting the lowest renal artery, the origin of the aneurysm, and the aortic bifurcation

Ideally, the aortic neck angle should be < 600

Angles that are greater lead to difficulties in implantation, kinking, endoleak, and the potential for distal device migration

Angle >600 is generally considered to be a contraindication

Page 18: Endovascular aneurysm  repair ( EVAR)

Measurements

Iliac artery & access vessel morphology

Should have no significant stenosis ,mural thrombus, calcification and tortuosity

CIA is the preferred distal attachment site

When the EIA is used for distal fixation the hypogastric artery need to be embolized to prevent back bleeding into the aneurysm sac

Page 19: Endovascular aneurysm  repair ( EVAR)

Measurements

Iliac artery & access vessel morphology

EIA diameter of 7 mm is needed to allow safe passage of the endograft delivery sheath.

CIA measure between 8 and 22 mm, and the length of normal diameter CIA into which the limbs of the endograft will be fixed should measure at least 15 to 20 mm to achieve an adequate seal

Diffuse narrowing or significant calcification - an iliac conduit can be created

Page 20: Endovascular aneurysm  repair ( EVAR)

Preoperative planning- Other anatomic considerations

Renal artery anomalies - up to 30% have accessory renal arteries &commonly originate from the lumbar aorta

Exclusion of an accessory renal vessel by an endograft can lead to partial renal infarction

Renal arteries often arise from the aneurysmal aortic segment

The inferior mesenteric artery arise from the aneurysm

Page 21: Endovascular aneurysm  repair ( EVAR)

Ideal case for EVAR

Proximal neck length >10mm

Diameter <28mm

Aortic neck angulation ≤60

Iliac artery diameter >7mm and < 15mm Minimal to moderate tortuosity No mural thrombus at attachment sites Minimal calcification

No associated mesenteric occlusive disease

Page 22: Endovascular aneurysm  repair ( EVAR)

Endografts (Stent-graft)

Fabric-covered stent

There are significant variations in endovascular graft design

Three types of components are common to all: A delivery system Main body device Extensions (limb)

Page 23: Endovascular aneurysm  repair ( EVAR)

EndograftsDelivery system

Typically delivered through the femoral artery, either percutaneously or by direct surgical cutdown

If the femoral artery is too small to accommodate the delivery system, access can be obtained by suturing a synthetic graft to the iliac artery (ie, iliac conduit) through a retroperitoneal low abdominal incision

The size of the delivery system varies depending upon the device diameter

Page 24: Endovascular aneurysm  repair ( EVAR)

EndograftsMain device 

The main body device is usually bifurcated

Endovascular grafts rely primarily upon outward tension in the proximal graft to maintain the positioning of the graft

Fixation systems may also include barbs or a suprarenal uncovered extension

Page 25: Endovascular aneurysm  repair ( EVAR)

EndograftsExtensions  

Bifurcated abdominal aortic grafts require adjunctive placement of iliac artery limbs to complete the graft

Iliac limbs on the main body device vary in length depending upon whether the graft is a 2 or 3 component graft

Two-component grafts have one short and one long iliac limb Three-component devices have two short limbs

Page 26: Endovascular aneurysm  repair ( EVAR)

Stent-graft design 

Six stent-graft systems are currently approved by FDA

1. AneuRx (Medtronic, Inc., Minneapolis, MN)

2. Talent (Medtronic, Inc., Minneapolis, MN)

3. Endurant (Medtronic, Inc., Minneapolis, MN),

4. Excluder (W.L. Gore and Associates, Flagstaff, AZ)

5. Zenith (Cook, Inc., Bloomington, IN)

6. Powerlink (Endologix, Irvine, CA)

Page 27: Endovascular aneurysm  repair ( EVAR)

Endografts

Figure   FDA-approved endovascular stent graft devices in use(A) AneuRx® device - This graft is a modular bifurcated stent graft composed of a nitinol exoskeleton and polyester lining. It is deployed just below the renal arteries and relies on radial force to fix the device into place. Distal and proximal extension cuffs are available. (B) The Gore Excluder -Also a modular bifurcated device, with a nitinol exoskeleton and a polytetrafluoroethylene graft. It has proximal barbs to anchor into the proximal infrarenal aorta. (C) The Powerlink®system- A unibody device made of polytetrafluoroethylene and a cobalt chromium alloy endoskeleton. It has a long main body and sits on the anatomic bifurcation. (D) The Zenith® device-The bare proximal stents allow for suprarenal fixation. The device also has barbs to allow for more secure attachment into the suprarenal aorta. It is modular bifurcated with a stainless steel exoskeleton.

Page 28: Endovascular aneurysm  repair ( EVAR)

Endografts

Page 29: Endovascular aneurysm  repair ( EVAR)

Endografts

Endurant® - The Endurant® endograft is a modular, bifurcated device composed of a multifilament polyester fabric with an external self-expanding support structure of M-shaped electro-polished nitinol stents. Proximally, it has a suprarenal nitinol stent with anchoring pins for suprarenal fixation. The graft design is intended to treat aneurysms with more challenging anatomy (eg, neck angulation)

Page 30: Endovascular aneurysm  repair ( EVAR)

Advanced devices and techniques 

Useful when aneurysmal disease is more extensive, involving the visceral vessels proximally or associated with common or hypogastric artery aneurysms

Fenestrated – Fenestrated endografts have openings in the fabric of the endograft, which allow flow into the visceral arteries. Can be used when the proximal aortic neck is short (ie, <10 mm)

Fenestrated Zenith® device with Palmaz stents designed for the treatment of juxtarenal abdominal aortic aneurysms

Page 31: Endovascular aneurysm  repair ( EVAR)

Advanced devices and techniques 

Branched – Branched grafts have a separate small graft sutured to the basic endovascular graft for deployment into a vessel to preserve flow into it. Branched grafts have been designed to accommodate the hypogastric (ie, internal iliac) and renal arteries

Model of an aorto-iliac aneurysm repair with a bifurcated aortobiiliac stent and a branched iliac extension device

Page 32: Endovascular aneurysm  repair ( EVAR)

Advanced devices and techniques 

Chimney grafts technique- a stent placed parallel to the aortic stent-graft

Used to preserve perfusion to branch vessels

Complications - type I endoleak

In the absence of available fenestrated or branched grafts, chimney grafts remain a feasible endovascular option for high-risk patients

Page 33: Endovascular aneurysm  repair ( EVAR)

Choice of graft 

There are no clear advantages of one stent-graft design over another

The choice is based upon multiple factors, including patient anatomy, operator preference, and cost

Bifurcated grafts are most often chosen, but are not appropriate for patients with unilateral severe iliac stenosis or occlusion.

Unilateral iliac stenosis - unibody (nonbifurcated) grafts, also known as aorto-uni-iliac (AUI) devices, are used

Page 34: Endovascular aneurysm  repair ( EVAR)

Choice of graft AUI devices are used when contralateral iliac access or gate

cannulation impossible, and for the treatment of some ruptured aneurysms for control of hemorrhage

To provide adequate perfusion to the contralateral lower extremity - a femoro-femoral crossover bypass

Aorto-uni-iliac (AUA) Device

Page 35: Endovascular aneurysm  repair ( EVAR)

Preparation

Antithrombotic therapy - moderate to high risk for DVT.The incidence of DVT following EVAR was 5.3 percent in spite of pharmacologic thromboprophylaxis

Antibiotic prophylaxis - A first generation cephalosporin or, in the case of a history of penicillin allergy, vancomycin, is recommended

Prevention of contrast-induced nephropathy

Page 36: Endovascular aneurysm  repair ( EVAR)

Procedure

Gaining vascular access

Placement of arterial guidewires and sheaths

Imaging to confirm aortoiliac anatomy

Main body deployment

Gate cannulation (bifurcated graft)

Iliac limb deployment

Graft ballooning

Completion imaging

Page 37: Endovascular aneurysm  repair ( EVAR)

Procedure

Anesthesia - can be performed under GA or local anesthesia with conscious sedation

Vascular access — Bilateral femoral access is needed - via surgical cutdown or percutaneously

Small caliber iliac vessels - iliac conduit or internal endoconduit

Graft deployment

Page 38: Endovascular aneurysm  repair ( EVAR)

Procedure

Once vascular access is established and landmarks for positioning the device are obtained with aortography, the main device is positioned with particular attention paid to the location of the opening for the contralateral iliac limb (“contralateral gate”)

Page 39: Endovascular aneurysm  repair ( EVAR)

Procedure

The aortic neck is imaged

A slight degree of craniocaudal and left anterior oblique angulation may improve imaging of the renal ostia

With the proximal radiopaque markers of the graft positioned appropriately

The body of the graft is deployed to the level of the contralateral gate

Page 40: Endovascular aneurysm  repair ( EVAR)

Procedure

The aortic neck is imaged

A slight degree of craniocaudal and left anterior oblique angulation may improve imaging of the renal ostia

With the proximal radiopaque markers of the graft positioned appropriately

The body of the graft is deployed to the level of the contralateral gate

Page 41: Endovascular aneurysm  repair ( EVAR)

Procedure

A guidewire is advanced through the contralateral access site into the contralateral gate.

Gate cannulation is confirmed by placing a pigtail catheter over the guidewire into the main body of the graft, removing the guidewire and confirming that the pigtail catheter rotates freely within the main body of the graft; if it does not, the catheter is assumed to be in the aneurysm sac

Page 42: Endovascular aneurysm  repair ( EVAR)

Procedure

Once the contralateral guidewire is positioned within the main body of the endograft, the deployment of the endograft at the neck of the aneurysm is completed followed by deployment of the contralateral, then ipsilateral iliac artery limbs (depending on the type of graft)

Page 43: Endovascular aneurysm  repair ( EVAR)

Procedure

Once the endograft components are in place, the attachment sites and endograft junctions are gently angioplastied with a compliant or semi-compliant balloon

Page 44: Endovascular aneurysm  repair ( EVAR)

Procedure

Completion aortography is performed to evaluate the patency of the renal arteries and evaluate for endoleak

Guidewire access is maintained throughout the procedure but is particularly important when removing the main graft body device sheath since disruption of the access vessels by an oversized sheath may not become apparent until after sheath has been removed

Page 45: Endovascular aneurysm  repair ( EVAR)

Troubleshooting “jailing the contralateral gate”

Deployment of the main body of the device with the gate low in the aneurysm sac or below the aortic bifurcation can lead to a situation in which the contralateral gate does not open up when the device is deployed

In some cases, pushing the device upward will allow the gate to flare open

Many currently available endovascular graft devices allow recapture of the graft to reorient the gate opening

If the gate of the graft cannot be moved more superiorly, conversion to an AUI configuration or open conversion may be needed

Page 46: Endovascular aneurysm  repair ( EVAR)

Troubleshooting Handling endoleak 

Endoleak is a term that describes the presence of persistent flow of blood into the aneurysm sac after device placement

Five types of endoleaks are described

Page 47: Endovascular aneurysm  repair ( EVAR)

Endoleak Classification

Type I - Persistent flow at proximal(a) or

distal(b) attachment sites

Type II—retrograde flow from side branches Inferior mesenteric lumbar arteries

Type III - graft defect

Type IV - graft porosity

Type V - continued aneurysm sac expansion without a demonstrable leak on any imaging modality

Page 48: Endovascular aneurysm  repair ( EVAR)

Endoleak 

Untreated type I or III endoleaks are at high risk of rupture and a rupture rate of 3.37%

Type II are the commonest endoleaks, affecting up to 43% of cases, associated with a low (0.52%) risk of rupture and a significant rate of spontaneous closure. Treatment is required only for endoleaks that persist for more than a year in an aneurysm of increasing size

Type IV endoleak typically resolves in 24 hours. It has not been associated with any long-term adverse events and does not require any treatment

Page 49: Endovascular aneurysm  repair ( EVAR)

Endoleak Treatment

Type Endovascular Open surgery

Type I Moulding balloon angioplastyGiant Palmaz stent Stent-graft cuff/ extension

External banding of aneurysm neckSurgical conversion

Type II Trans-arterial embolisation Trans-lumbar injection

30% decrease

Type III Angioplasty/ stenting of junctionsSecondary graft placement

Open conversion

Type VCo-axial graft(‘re-lining’) Evacuation of hygroma

Open conversion

Page 50: Endovascular aneurysm  repair ( EVAR)

Postoperative care 

Ambulation is resumed on the first postoperative day

peripheral pulse exam should be assessed at regular intervals

Page 51: Endovascular aneurysm  repair ( EVAR)

EVAR complicationsDeployment related

Failed deployment

Bleeding

Hematoma

Lymphocoel

Infection

Embolization

Perforation

Arterial rupture

Dissection

Device relatedStructural failure

Implant relatedEndoleaks

Limb occlusion/stent-graft kink

Sac enlargement/proximal neck dilatation

Stent migration

AAA rupture

Infection

Buttock/leg claudication

Page 52: Endovascular aneurysm  repair ( EVAR)

EVAR complications

Systemic Cardiac Pulmonary Renal insufficiency, contrast-induced neuropathy Deep vein trombosis Pulmonary embolism Coagulopathy Bowel ischemia Spinal cord ischemia

Page 53: Endovascular aneurysm  repair ( EVAR)
Page 54: Endovascular aneurysm  repair ( EVAR)

EVAR complications Postoperative device migration

Device movement of >10 mm relative to anatomic landmark with the use of 3-D CT reconstruction or any migration leading to symptoms or requiring intervention

Multifactorial: Aortic neck length, angulation, nonparllel aortic neck, thrombus in the aortic neck

Short neck and late neck dilatation after EVAR is a major cause of concern because of the potential loss of proximal fixation and seal

Complications Endoleak Aneurysm expansion & rupture

Page 55: Endovascular aneurysm  repair ( EVAR)

EVAR complications Postoperative device migration

A case series of in 130 patients treated for AAA (AneuRx® & Zenith®)

With AneuRx®, device migration- in 14 of 130 patients. Freedom from device migration was 96, 90, 78, and 72%t at 1,2,3,&4yrs respectively

The initial neck length was shorter in patients with migration compared with patients who did not demonstrate migration (22 vs 31 mm). Aortic neck dilation (≥3 mm) occurred in 22%. Twelve of the 14 patients underwent secondary procedures (13 endovascular, 1 open conversion)

With Zenith®, freedom from device migration was 100, 98, 98, and 98 percent at 1,2,3 & 4 yrs, respectively. The single patient with stent migration did not require treatment

Tonnessen BH et al. J Vasc Surg 2005; 42:392.

Page 56: Endovascular aneurysm  repair ( EVAR)

Latest Advances in Prevention of Distal Endograft Migration and Type 1 Endoleak

Superstiff-Guidewire Technique: Maneuvers like bending the guidewire before introduction, in order to align it with the axes of the aneurysm and the neck, could be helpful.

Also of benefit is the use of a superstiff guidewire,such as the 0.035-inch Lunderquist or the 0.035-inch Amplatz® in combination with slow and controlled deployment of the endograft

Useful in patients with severe infrarenal neck angulation, short infrarenal necks, or both

A 0.035-inch superstiff guidewire is bent to conform theendograft to tortuous infrarenal aortic neck anatomy

Page 57: Endovascular aneurysm  repair ( EVAR)

Latest Advances in Prevention of Distal Endograft Migration and Type 1 Endoleak

Combination Technique Using the Palmaz XL Stent with the Excluder Stent-Graft:

Used in patients who have complicated infrarenal neck anatomy

The permanent deployment of the Palmaz® XL stent in the infrarenal neck before permanent deployment of the Excluder endograft

This technique has been shown to offer a reliable mode of Excluder fixation and prevention of distal migration

Page 58: Endovascular aneurysm  repair ( EVAR)

Latest Advances in Prevention of Distal Endograft Migration and Type 1 Endoleak

Endowedge Technique with Excluder Stent-Graft

Useful in short infrarenal neck anatomy

Juxtarenal sealing during endograft placement

Technique enables the scalloped proximal 4 mm of the Excluder endoprosthesis to be wedged against the renal angioplasty balloons, which are placed via the brachial approach

The first 2 to 3 rings of the endograft are slowly deployed (flowering technique), and then the device is advanced upwards against the inflated renal balloons for the completion of deployment

Page 59: Endovascular aneurysm  repair ( EVAR)

Latest Advances in Prevention of Distal Endograft Migration and Type 1 Endoleak

Kilt Technique :

In patients who have funnel-shaped aortic necks

An aortic cuff is deployed in the distal infrarenal seal zone before the main body is deployed

The proximal end of the Excluder contains barbs, which enable the device to remain above the aortic extension and thereby prevent distal migration

Careful inflation of an angioplasty balloon of the appropriate size then achieves the proximal seal of the prosthesis

Page 60: Endovascular aneurysm  repair ( EVAR)

Latest Advances in Prevention of Distal Endograft Migration and Type 1 Endoleak

Anatomic Fixation with the Powerlink Stent-Graft

Page 61: Endovascular aneurysm  repair ( EVAR)

Latest Advances in Prevention of Distal Endograft Migration and Type 1 Endoleak

The Aorfix Endovascular AAA Repair System : currently undergoing clinical trial. The proximal part of the Aorfix has incorporated nitinol clips for active fixation of the device to the aortic wall

The Anaconda device: undergoing clinical trials .This is the only graft system that enables repositioning of the graft after deployment. It is highly flexible and has good torque control

Page 62: Endovascular aneurysm  repair ( EVAR)

Postoperative Surveillance

30 Days: CTA and X-ray Abdomen PA + lateral

6 Months: CTA can be omitted if no prior endoleak and good component overlap

1 Year: CTA and X-ray Abdomen PA+lateral

If no endoleak and stable/shrinking AAA Annual doppler US with plain radiographs CTA if increasing diameter or new endoleak

Page 63: Endovascular aneurysm  repair ( EVAR)

all mortality aneurysm mortality0

3

6

9

EVAR 1

• 30-day operative mortality: 1.8% with endovascular repair vs. 4.3% with open repair

• All-cause death rate: 7.5/100 person-yrs vs. 7.7/100 person-yrs, respectively

• Aneurysm-related death rate: 1.0/100 person-yrs vs. 1.2/100 person-yrs, respectively

• Late ruptures only occurred in the endovascular repair group

Trial design: Patients with an abdominal aortic aneurysm were randomized to endovascular repair (n = 626) vs. open repair (n = 626). Median follow-up was 6 years.

Results

Conclusions• Among patients with abdominal aortic

aneurysm, endovascular repair associated with lower operative mortality with similar long-term all-cause mortality

• Greater overall frequency of complications after endovascular repair

EVAR Trial Investigators. N Engl J Med 2010;Apr 11:[Epub]

(p = 0.72) (p = 0.73)

Endovascular repair Open repair

per 1

00 p

erso

n-ye

ars 7.5 7.7

1.0 1.2

All-cause death Aneurysm-related death

Page 64: Endovascular aneurysm  repair ( EVAR)

EVAR 2

all mortality aneurysm mortality0

12

24• 30-day operative mortality: 7.3% with

endovascular repair• Rupture rate in the no repair group: 12.4/100

person-yrs• All-cause death rate: 21.0/100 person-yrs with

endovascular repair vs. 22.1/100 person-yrs with no repair

Trial design: Patients with an abdominal aortic aneurysm ineligible for surgery were randomized to endovascular repair (n = 197) vs. medical management (n = 207). Median follow-up was 3.1 years.

Results

Conclusions

EVAR Trial Investigators. N Engl J Med 2010;Apr 11:[Epub]

(p = 0.97) (p = 0.02)

Endovascular repair No repair

per 1

00 p

erso

n-ye

ars

21.0 22.1

3.6

7.3

All-cause death rate

Aneurysm-related death rate

• In patients with abdominal aortic aneurysm, ineligible for open surgery repair, endovascular repair is associated with relatively high operative mortality

• Aneurysm-related deaths reduced from endovascular repair; but no reduction in all-cause mortality

Page 65: Endovascular aneurysm  repair ( EVAR)

survival reintervention60

70

80

90

DREAM

• Survival: 69% with endovascular repair vs. 70% open repair (p = 0.97)

• Freedom from reintervention: 70% vs. 82% (p = 0.03), respectively

• In the endovascular repair group, common causes for reintervention were thrombo-occlusive disease, endoleak, and graft migration

• In the open repair group, a common cause for reintervention was treatment of incisional hernia

Trial design: Patients with an abdominal aortic aneurysm were randomized to endovascular repair (n = 173) vs. open repair (n = 178). Median follow-up was 6.4 years.

Results

Conclusions• Among patients with abdominal aortic

aneurysm, endovascular repair results in similar long-term survival as open repair; however, this approach results in the need for significantly more reinterventions

De Bruin JL, et al. N Engl J Med 2010;362:1881-9

(p = 0.97) (p = 0.03)

Endovascular repair

Open repair

%

Survival Freedom from reintervention

69 70 70

82

Page 66: Endovascular aneurysm  repair ( EVAR)

OVER

• 30-day mortality ↑ with open repair (2.3% vs. 0.2%, p = 0.006); no difference at 2 years (9.8% vs. 7.0%, p = 0.13)

• MI: 2.7% vs. 1.4%, p = 0.14; stroke: 0.9% vs. 1.6%, p = 0.38

• Procedural time, duration of hospital stay ↓ in EVAR arm (p < 0.001)

Trial design: Patients with unruptured AAA were randomized to endovascular repair (EVAR) or open surgical repair. Patient follow-up was a mean of 1.8 years.

Results

Conclusions

Lederle FA, et al. JAMA 2009;302:1535-42

(p = 0.13)

Open repair(n = 437)

EVAR(n = 444)

Mortality at 2 years

• Mid-term outcomes similar with EVAR and open repair for unruptured AAA; length of stay and procedural time was shorter for EVAR

• Results are contrary to two other published trials; long-term results are awaited

0

10

20

% 9.8

7.0

2.71.4

%

0

20

MI at 1 year

(p = 0.14)

10

Page 67: Endovascular aneurysm  repair ( EVAR)

Review of EvidenceEVAR vs OSR

Page 68: Endovascular aneurysm  repair ( EVAR)

Thoracic endovascular aneurysm repair (TEVAR)

Page 69: Endovascular aneurysm  repair ( EVAR)

Introduction

TEVAR refers to the percutaneous placement of a stent graft in the descending thoracic or thoracoabdominal aorta in patients with aortic aneurysms

Preoperative planning

Page 70: Endovascular aneurysm  repair ( EVAR)

Conduct of the operationProcedure is typically done under GA

A lumbar drain is placed in the L3-L4 disc space for drainage of CSF in cases where extensive coverage of the thoracic aorta is anticipated where interruption of contributing blood supply to the artery of Adamkiewicz is high

Lumbar drainage of cerebrospinal fluid to decrease the pressure in the subarachnoid space and increase the spinal cord perfusion pressure

Page 71: Endovascular aneurysm  repair ( EVAR)

Anatomic considerations

The thoracic aorta is of larger caliber than that of the infrarenal aorta so needs larger diameter stent grafts

There is high force of blood flow in the thoracic aorta so requires a longer seal zone (20 mm both proximal and distal)

Hybrid approach- for proximal aneurysm

Page 72: Endovascular aneurysm  repair ( EVAR)

Stent Grafts

Gore-TAG device -made of e-PTFE and an exoskeleton made of nitinol. The proximal and distal ends of the graft have scalloped flares

Medtronic Talent thoracic stent graft system . It is made of two components, a proximal straight tubular stent graft with a proximal bare stent & a distal tapered tubular stent graft with an open web proximal configuration & closed web distal configuration It consists of a woven polyester graft with a nitinol endoskeleton. studied in the VALOR I trial

Page 73: Endovascular aneurysm  repair ( EVAR)

Stent Grafts

The Cook TX2 stent graft is a two-piece modular endograft system made of proximal and distal tubular endografts. The proximal endograft is covered and has stainless steel barbs, allowing for active fixation to the aortic wall. The distal component has at its distal end a bare metal. The TX2 is made of Dacron fabric covered by stainless steel Z-stents.

The Bolton Relay stent graft is an investigational device

Page 74: Endovascular aneurysm  repair ( EVAR)

Perioperative complications

Perioperative stroke has ranged from 4 percent to 8 percent

The risk of spinal cord ischemia - 3 to 11 percent

Visceral ischemia can occur with coverage of the celiac axis

Page 75: Endovascular aneurysm  repair ( EVAR)

Review of Evidence

Page 76: Endovascular aneurysm  repair ( EVAR)

Review of Evidence TEVAR vs OSRVALOR 1 trial

5-year outcomes of TEVAR using the Vascular Talent Thoracic Stent Graft System in pts considered low or moderate risk for OSR

195 patients, prospective, nonrandomized, multicenter study

Freedom from all-cause mortality - 83.9% at 1 yr & 58.5% at 5yrs

Freedom from aneurysm-related mortality (ARM) was 96.9% at 1 year and 96.1% at 5 years

The 5-year freedom from aneurysm rupture was 97.1% and the 5-year freedom from conversion to surgery was 97.1%

The incidence of stent graft migration was ≤1.8% in each year

The 5-yr freedom from secondary endovascular procedures -81.5%

Page 77: Endovascular aneurysm  repair ( EVAR)

42 nonrandomized studies - 5,888 patients (38 comparative studies, 4 registries)

Conclusion: TEVAR may reduce early death, paraplegia, renal insufficiency, transfusions, reoperation for bleeding, cardiac complications, pneumonia, and length of stay compared with open surgery

Sustained benefits on survival have not been proven

Page 78: Endovascular aneurysm  repair ( EVAR)

MCQ

Page 79: Endovascular aneurysm  repair ( EVAR)

MCQ.1

False statement regarding AAA is

A. AAA that has expanded by more than 0.5 cm within a six-month interval is an indication for EVAR

B. More than 15% percent involve the renal or visceral arteries

C. Up to 40 percent of AAAs are associated with iliac artery aneurysm

D. Majority of endovascular aneurysm repairs are performed on aneurysms affecting the infrarenal aorta and iliac arteries

Page 80: Endovascular aneurysm  repair ( EVAR)

MCQ.2

Incorrect matching is?

A. Aortic neck diameter - Aortic diameter at the lowest renal artery

B. Aortic neck length - The distance from the lowest renal artery to the aortic bifurcation

C. Ideal aortic neck angle less than 60º- EVAR feasible

D. Iliac artery diameter >7mm and < 15mm – EVAR feasible

Page 81: Endovascular aneurysm  repair ( EVAR)

MCQ.3

Fill in the blanks

Post operative stent migration in EVAR defined as Device movement of more than ------------- mm relative to anatomic landmark or any migration leading to symptoms or requiring intervention

A. 5

B. 10

C. 15

D. 20

Page 82: Endovascular aneurysm  repair ( EVAR)

MCQ.4

False statement about endograft is

A. There are no clear advantages of one stent-graft design over another

B. The main body device is usually bifurcated

C. Endovascular grafts rely primarily upon outward tension in the distal graft to maintain the positioning of the graft

D. Fixation systems may also include barbs or a suprarenal uncovered extension

Page 83: Endovascular aneurysm  repair ( EVAR)

MCQ.5

An 88-year-old man who presented with tearing mid abdominal pain 4 months after EVAR. DSA taken. What is your diagnosis ?

A. Type 1 Endoleak

B. Type 2 Endoleak

C. Type 3 Endoleak

D. Endotension

Page 84: Endovascular aneurysm  repair ( EVAR)

MCQ.6

What is the most appropriate treatment

in the above case ?

A. deployment of covered stent over defect

B. Regular follow up by CT scan

C. Open surgical repair

Page 85: Endovascular aneurysm  repair ( EVAR)

MCQ.7

Correct order of stent deployment in EVAR of AAA

A. Endograft at the neck of the aneurysm →contralateral limb → ipsilateral iliac artery limbs

B. Contralateral limb → Endograft at the neck of the aneurysm →ipsilateral iliac artery limbs

C. contralateral limb→ Ipsilateral iliac artery limbs→ Endograft at the neck of the aneurysm

Page 86: Endovascular aneurysm  repair ( EVAR)

MCQ.8

False statement regarding EVAR is

A. A femoro-femoral crossover bypass may be needed in aorto uniiliac device

B. EVAR has better short term prognosis than OR

C. EVAR is better than OR in terms of long term prognosis

D. EVAR can be done under regional anaesthesia

Page 87: Endovascular aneurysm  repair ( EVAR)

MCQ.9

False statement is?

A. MR angiography Is the investigation of choice in pre EVAR work up

B. The required endograft diameter = 15 to 20% more of measured aortic neck diameter

C. DSA cannot evaluate the true lumen diameter

D. 2D CT- aortic diameter measurements will be overestimated if the aorta is angulated

Page 88: Endovascular aneurysm  repair ( EVAR)

MCQ.10Images of a thoracic pseudo aneurysm repair procedure. What is your

comment about the stent length?

A. Adequate size

B. Under sized

C. Over sized

Page 89: Endovascular aneurysm  repair ( EVAR)

MCQ.1

False statement regarding AAA is

A. AAA that has expanded by more than 0.5 cm within a six-month interval is an indication for EVAR

B. More than 15% percent involve the renal or visceral arteries

C. Up to 40 percent of AAAs are associated with iliac artery aneurysm

D. Majority of endovascular aneurysm repairs are performed on aneurysms affecting the infrarenal aorta and iliac arteries

Page 90: Endovascular aneurysm  repair ( EVAR)

MCQ.2

Incorrect matching is?

A. Aortic neck diameter - Aortic diameter at the lowest renal artery

B. Aortic neck length - The distance from the lowest renal artery to the aortic bifurcation

C. Ideal aortic neck angle less than 60º- EVAR feasible

D. Iliac artery diameter >7mm and < 15mm – EVAR feasible

Page 91: Endovascular aneurysm  repair ( EVAR)

MCQ.3

Fill in the blanks

Post operative stent migration in EVAR defined as Device movement of more than ------------- mm relative to anatomic landmark or any migration leading to symptoms or requiring intervention

A. 5

B. 10

C. 15

D. 20

Page 92: Endovascular aneurysm  repair ( EVAR)

MCQ.4

False statement about endograft is

A. There are no clear advantages of one stent-graft design over another

B. The main body device is usually bifurcated

C. Endovascular grafts rely primarily upon outward tension in the distal graft to maintain the positioning of the graft

D. Fixation systems may also include barbs or a suprarenal uncovered extension

Page 93: Endovascular aneurysm  repair ( EVAR)

MCQ.5

An 88-year-old man who presented with tearing mid abdominal pain 4 months after EVAR. DSA taken. What is your diagnosis ?

A. Type 1 Endoleak

B. Type 2 Endoleak

C. Type 3 Endoleak

D. Endotension

Page 94: Endovascular aneurysm  repair ( EVAR)

MCQ.6

What is the most appropriate treatment in the above case ?

A. deployment of covered stent over defect

B. Regular follow up by CT scan

C. Open surgical repair

DSA obtained after deployment of covered stent over defect shows no further contrast leakage.

Page 95: Endovascular aneurysm  repair ( EVAR)

MCQ.7

Correct order of stent deployment in EVAR of AAA

A. Endograft at the neck of the aneurysm →contralateral limb → ipsilateral iliac artery limbs

B. Contralateral limb → Endograft at the neck of the aneurysm →ipsilateral iliac artery limbs

C. contralateral limb→ Ipsilateral iliac artery limbs→ Endograft at the neck of the aneurysm

Page 96: Endovascular aneurysm  repair ( EVAR)

MCQ.8

False statement regarding EVAR is

A. A femoro-femoral crossover bypass may be needed in aorto uniiliac device

B. EVAR has better short term prognosis than OR

C. EVAR is better than OR in terms of long term prognosis

D. EVAR can be done under regional anaesthesia

Page 97: Endovascular aneurysm  repair ( EVAR)

MCQ.9

False statement is?

A. MR angiography Is the investigation of choice in pre EVAR work up

B. The required endograft diameter = 15 to 20% more of measured aortic neck diameter

C. DSA cannot evaluate the true lumen diameter

D. 2D CT- aortic diameter measurements will be overestimated if the aorta is angulated

Page 98: Endovascular aneurysm  repair ( EVAR)

MCQ.10

Images of a thoracic pseudo aneurysm repair procedure. What is your comment about the stent length?

A. Adequate size

B. Under sized

C. Over sized

Page 99: Endovascular aneurysm  repair ( EVAR)