edison biotechnology institute newsletter - ohio university · 2019-08-06 · the report, which was...

Edison

Biotechnology

Institute

Newsletter

Edison Biotechnology Institute Newsletter

Edison Biotechnology Institute NewsletterIssue 07: December 2015

CONTENT

NEWS

EVENTSFOCUS

OU Ranked Firstin Research Revenue 02

TechGrowth Ohio 02

Natural Products Research Center 03

The Endo Retreat 042015Visit with Herb Medicine Partners in Japan

05

Kopchick Awards06-07

STORY

Visiting Students08

HIGHLIGHTS

Puclication List09-10

Postdocs from EBI09

Claire Schomaker Rachel Beha Xuan Wang Silvana Duran-Ortiz Yanrong Qian Wangyuxuan Xu

List of Editors


NEWSOU Ranked First in Research Revenue

TechGrowth Ohio

Ohio University first in state for University research revenue

Claire Schomaker

Ohio University has once again ranked firstamong Ohio higher education institutions for research licensing revenue. According to the annual report released by The Association of University Technology Managers (AUTM), faculty inventions generated approximately $10.6 million during fiscal year 2014. The report, which was released in September, also noted that Ohio University generated $60.8 million in research and sponsored program funding. The majority of the revenue comes from an Ohio University license to the Pfizer Corporation for a growth hormone receptor antagonist discovered by Edison

Biotechnology Institute scientist, John Kopchick, and former graduate student Wen Chen in 1987. The technology became the basis for the drug Somavert, a treatment for people with acromegaly, a growth hormone disorder that can cause excessive growth of organs and bones in adults and can lead to premature death. Ohio University reinvests the licensing revenue in biomedical research initiatives, academic programs and technology commercialization efforts.

TechGROWTH Ohio was recognized as thewinner of the 2015 Council of Development Finance Agencies (CDFA) Ohio Financing Roundtable Excel-lence Award for Program. In view of their great input in connecting entrepreneurs with assistance and offering valuable tools for growth and sources of funding to early-stage, technologically-innovative companies, TechGROWTH Ohio was awarded this statewide excellent award. TechGROWTH was best recognized

by the CDFA for its impact which shows a leverage ra-tio of over $9 of follow-on resources acquired for client companies for every $1 of state money invested, achiev-ing more than $218 million flowing into the Southeast Ohio region over its first seven years. (Comprised of the nation’s leading and most knowledgeable members of the development finance community representing 400+ public, private and non-profit development entities, the national association Council of Development Finance Agencies dedicates to the advancement of devel opment finance concerns and interests. The CDFA Ohio Financing Roundtable Excellence Awards honor excellence in the use of financing tools for economic development, as well as the individuals who champion those efforts.)

Natural Products Research Center

Xuan Wang


NEWSOU Ranked First in Research Revenue

TechGrowth Ohio



Many pharmaceuticals, exemplified by the antican-cer drug taxol and the anti-cholesterol statin drugs, have been derived, directly or indirectly, from natural products. Indeed, the 2015 Nobel Prize in medicine was awarded for the discovery of treatments for parasitic infections from bacterial and plant extracts. As interest in potential therapies from traditional herbal medicines grows, the National Institutes of Health is encouraging the development of centers of excellence in natural products research, and the Edison Biotechnology Institute is spearheading the creation of a new Natural Product Research Center (NPRC) at Ohio University headed by Drs. Jeff Wiseman and Shiyong Wu. A project that has been talked about for years was implemented this summer with the help of postdocs Haotong Chen and Hyun Young Park, who have extensive previous experience in the natural products field. While the Natural Product Research Center at Edison Institute is not yet connected with other NPRCs across the country, they are working to build an international network of collaborators with the goal of establishing a center of excellence in the field.

Claire Schomaker Wiseman says that the goal is to apply the biotech-nology expertise at EBI coupled with analytical capabil-ities in the Department of Chemistry and clinical evaluations at the Diabetes Institute and Heritage Col-lege of Medicine to develop herbal supplements with demonstrated benefit while avoiding the enormous capital investments associated with traditional drug discovery. With herbal medicines accepted as therapies in much of the world, Wiseman notes that herbal medicines drastically lower the cost of therapy for an enormous population of patients with low incomes and no health insurance compared to the cost of patented drugs developed in the US and Europe. Currently EBI is collaborating with the Ohio University College of Medicine, specifically the Ohio Musculoskeletal and Neurological Institute, to develop a clinical evaluation of maca root to protect muscle function in aging patients. EBI is analyzing samples of maca root from multiple suppliers to identify sources with high levels of active ingredients and low levels of potential toxins such as insecticides and heavy metals. In addition, Drs. Haotong Chen and Hyun Young Park are extending previous studies in the lab of Dr. Xiaozhu Chen to identify active ingredients in the Banaba leaf from the Philippines whose leaves have been used for anti-diabetic purposes. Wiseman also notes that just because herbal supplements come from plants does not mean they are safe. Some plants have toxic components which need to be identified and separated from the desirable components, and Ms. Misako Hata and Dr. Ishrat Jahan have begun to develop tests to identify these toxic components, with the ultimate goal of removing these from the final plant preparation.

Natural Products Research Center:

Dr. Jeff Wiseman, Ishrat Jahan, Dr. Hyun Young Park, Dr. Haotong Chen and Misa Hata

EVENTS

Page 04Edison Biotechnology Institute Newsletter

THE ENDO RETREAT 2015 Visit with Herb Medicine Partners in Japan

EBI ATTENDS THE ENDO RETREAT 2015

The Endo Retreat was held October 6ththrough 10th of 2015 in Rotterdam, The Netherlands. A group of 8 students and researchers from the Edison BiotechnologyInstitute led by Dr. John Kopchick, Distinguish Professor, Goll-Ohio Eminent Scholar at Ohio University, attended this meeting. Also attending the Endo Retreat were 8 internationally recognized research groups that work in the field of Growth hormone, Insulin Growth Factor-I, Prolactin and Adipose tissue. These research groups included the group of Dr. Vincent Goffin and Dr. Paul Kelly from the Inserm and University Paris Descartes, Dr. Teresa Wood from New Jersey Medical School and Cancer Center, Dr. Sebastian Neggers and Dr. Jenny Visser from Erasmus Medical Center, and Dr. John Kopchick and Dr. Darlene Berryman from the Edison Biotechnology Institute at Ohio University, between others. The Endo Retreat is a meeting that started in the year 2002 and is celebrated every 18 months. Through-out the years the Endo Retreat has been sponsored by multiple members of the industry. This year the retreat was sponsored by Pfizer, IPSEN and Novartis pharma-ceuticals. The Endo Retreat meeting was conceived

by Dr. Kopchick, Dr. Wood and Dr.Kelly as an effort to im-prove and increase research collabora-tions, as well as to provide a setting for young trainees to showcase and pres-ent their work in a

friendly, but high level academic environment. Therefore, one of the absolute requirements for trainees to attend is to present their research work in a 15 min presentation, followed by a 5-10 min discussion. Settings as the Endo Retreat are invaluable opportuni-ties for the students. This meeting allows trainees to give an oral presentation and discuss results and future re-search plans in a very intimate environment with top level scientist that are involved in similar fields. There-fore, expanding the knowledge and horizons of the research, as well as engagement in interesting discussion and forming new collaborations are just some of the experiences that the Endo Retreat provides its attendees.

Save The DateBig Data, Computation and Systems Biology in CancerDecember 2-5, 2015 • Suzhou Dushu Lake Conference Center • Suzhou, ChinaLung Cancer Translational Science from the Bench to the ClinicJanuary 4-7, 2016 • Hard Rock Hotel • San Diego, CA

The Function of Tumor Microenvironment in Cancer Progression January 7-10, 2016 • Hard Rock Hotel • San Diego, CAObesity and Adipose Tissue BiologyFebruary 15—19, 2016. Fairmont Banff Springs, Banff, Alberta, Canada

Silvana Duran-Ortiz


EVENTS THE ENDO RETREAT 2015 Visit with Herb Medicine Partners in Japan

From Sept. 18 – Oct. 1st, Dr. Shiyong Wu, Directorof EBI and Professor of Chemistry and Biochemistry, OU, along with Dr. Christopher Thompson, Department Chair of Linguistics, OU, visited Hokuriku University (HU), Chubu University, Chiba University and Iwate Prefectural University (IPU) to discuss potential collab-orative projects for research and economic development. HU was funded in 1975 with a single College of Pharma-cology Sciences and has 20 years of good relationship with OU. HU has a tradition in herb medicine research and a good collection of medic-inal plants. During the visit, Dr. Wu met with Drs. Kobayashi, Tezuka and Nomura to discuss possible fu-ture collaboration on research of oriental medicines and educa-tion of future-phar-macist; and visited their herb medicine green house and garden. Dr. Kobayashi also indicat-ed that he will make an effort to connect EBI’s Natural Products Research Team with Kobayashi Pharmaceutics, a Japanese company that develops and markets herb medicine, in regarding potential collaboration in devel-opment, evaluation, manufacture and marketing of herb medicines in US. After visiting HU at Kanazawa, Dr. Wu headed to Chubu U., which has more than 40 years of good relationship with OU. At Chubu U, Dr. Wu dis-cussed with Dr. Qiao, the Deputy Director of International Affairs and Professor of Biomedical

Sciences, regarding further sponsored research collaboration between the two universities. Then Dr. Wu visited Dr. Ishibashi, Professor of Natural Product Research Institute (NPRI) at Chiba U. and formal supervisor of Dr. Hyun Young Park, a post-dr. fellow at EBI. The Faculty of Pharma-ceutical Sciences of Chiba U. has more than 120 years of history. Dr. Ishbashi is an expert in isolation, characterization and synthesis

of active ingredients of herb medicine; and he showed interests in future collaboration with the Natural Product Research Team at EBI. The final stop for Dr. Wu was IPU. Led by Dr. Thompson, OU has been working with IPU on a Tsunami Relief Volunteer Project since Sept. 2011. During this visit, Dr. Wu discussed with Dr.

Chiba for a collaborative research project in studying heavy metal contamination before and after the tsunami in food consumed by local people in Iwate Prefecture. Sponsored by the Offices of VPR and Dean of A&S, the Department of Chemistry & Biochemistry and EBI are acquiring an ICP-MS for analyzing trace amounts of heavy metals in foods, plants and environment. The instrument will be used for the OU-IPU collaboration.

Photo by Dr. Shiyong WuText by Dr. Shiyong Wu

FOCUS Kopchick Awards


Kopchick Awards provide $87,795 to OHIO student, faculty and staff researchers{

Text by the Office of Research CommunicationsPhoto by Kaitlin Owens/Ohio University

Fourteen Ohio University students and facultyand staff members have received funding for their health and medical research from the John J. Kopchick Awards.

The program provided a total of $87,795 in grants and fellowships to advance research on topics such as obesity, diabetes and neurodegenerative diseases. The recipients were recognized during a ceremony Nov. 14 in Nelson Commons.

“These awards reflect the diversity of translational biomedical research conducted by our faculty and students and reinforce the significance of applying new knowledge to clinically relevant and unmet needs,” said Joseph Shields, vice president for research and creative activity and dean of the Graduate College.

The John J. Kopchick Molecular and Cellular Biology (MCB)/Translational Biomedical Sciences (TBS) Facul-ty Support Fund, Research Fellowship Award and

Undergraduate Student Support Fund were created as a result of a $2 million gift commitment from John Kopchick, Goll-Ohio Eminent Scholar, Distinguished Professor of Molecular Biology, and EBI Principle Investigator and Char Kopchick, Assistant Dean of Students at Ohio University.

In addition, the deans of the Russ College of Engi-neering and Technology, College of Arts and Sciences, Heritage College of Osteopathic Medicine and College of Health Sciences and Professions, as well as the vice president for research and creative activity, are provid-ing a total of $1.9 million in match support.

The John J. Kopchick Awards support undergraduate and graduate students and faculty affiliated with Ohio University’s Molecular and Cellular Biology program and Translational Biomedical Sciences program. Both programs take an interdisciplinary approach to solving complex research questions in the science and medical fields.

FOCUS Kopchick Awards


{Board of the 2016 Kopchick Awards Recipients

John J. Kopchick Molecular and Cellular Biology (MCB)/Translational Biomedical Sciences (TBS) Faculty Support Fund (up to $10,000 for MCB/TBS faculty for research activities and conference travel)

Recipients: Darlene Berryman, Erin Murphy, Ronan Carroll and Ed List

Recipient: Xiao Chen

John J. Kopchick Molecular and Cellular Biology (MCB)/Translational Biomedical Sciences (TBS) Research Fellowship Award (up to $10,000 for PhD and DO/PhD

students in the MCB or TBS programs to support translational biomedical research, with an additional $5,000 for an off-campus internship).

John J. Kopchick Molecular and Cellular Biology (MCB)/Translational Biomedical Sciences (TBS) Undergraduate

Student Support Fund ( up to $1,500 for undergraduate students working with MCB/TBS faculty and conducting translational medical research and scholarly activities)

Recipents: Debra Walter, Elizabeth Jensen, Alison Brittain, Ian Ackers, and Ashley Patton

Recipents: Caroline Wilson, Kimberly Kraus, and Emma Kessler

Photo by Kaitlin Owens/Ohio University Text by the Office of Research Communications Out of the 14 recipients of the Kopchick Awards, 3 are EBI faculty, 2 are EBI graduate

students and 1 is an EBI undergraduate student.

STORY Visiting Students


My name is Marcella van Hoolwerff and I am a master’s student from the University of Leiden, The Netherlands. I live in Delft, which is a small city of about 100,000 habitants, where I live with 8 housemates and my rabbit. I came to Athens in

June to do research in the lab of prof. Kopchick for half a year, as part of my curriculum. I arrived in the sum-mer which started a bit wet, but the warm and sunny days were a welcome change from the Dutch (usually) grey skies and windy days. In those 5 months that I’ve been here we had a lot of lab parties, which was great. I didn’t think there could be a lab where work and fun really go hand in hand, like it does here. I respect everyone working in the Kopchick lab, where the work ethic is so high. What surprised me was how co-operative everyone is, you can ask anyone for help and you will find the person with the right knowl-edge. And also not only by asking questions but by discussing findings or theories we learn so much from one another. Working in this lab has showed me how to become independent thanks to the open atmosphere and it has been an inspiring experi-ence. On the other hand the fun we had during and after work made my stay here unforgettable. Therefore I would like to thank everyone from the lab for receiving me with open arms.

My name is Rikke and I am a visiting student from Denmark. I obtained my master’s degree in Molec-ular Medicine in 2013 and began my PhD at the Medi-cal Research Laboratory and Department of Endocri-nology and Metabolism at Aarhus University in 2014. Denmark is a small country and students are gener-ally encouraged to go abroad, visit other universities and “bring home knowledge”. For my master’s project, I studied the regulation of the GH/IGF system in human

adipose tissue, so when my Danish supervisor told me that he “knew this great group in Ohio, who was also interested in GH and adipose tissue”, I was set to go. Since the end of March, I have conducted research at the Edison Biotech-nology Institute at Ohio University under kind

(and patient) guidance and supervision by Dr. Darlene Berryman and Dr. John Kopchick. Thanks to them and many others, my time here at EBI, at OU and in Athens has been and still is a great experience. I have the plea-sure of working with talented scientists and scientists. I am learning numerous new techniques and given the opportunity to share opinions and knowledge on specif-ic topics.Most importantly, it is a great motivation and inspiration to see established scientists that are still so driven by their curiosity.


Posdocs from EBI

PublicationList

From January 1, 2014 - November 30, 2015Growth Hormone Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults. Allen DB, Backeljauw P, Bidlingmaier M, Biller B, Boguszewski M, Burman P, Butler G, Chihara K, Christiansen JS, Cianfarani S, Clayton PE, Clemmons D, Cohen P, Darendeliler F, Deal C, Dunger DP, Erfurth EM, Fuqua J, Grimberg A, Haymond M, Higham C, Ho KK, Hoffman AR, Hokken-Koelega AC, Johannsson G, Juul A, Kopchick JJ, Lee P, Pollak M, Radovick S, Robison L, Rosenfeld R, Ross RJ, Savendahl L, Saenger P, Toft Sorensen H, Stochholm K, Strasburger CJ, Swerdlow A, Thorner MO.Eur J Endocrinol. 2015 Nov 12. pii: EJE-15-0873. [Epub ahead of print] PMID: 26563978

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells.Granchi C, Qian Y, Lee HY, Paterni I, Pasero C, Iegre J, Carlson KE, Tuccinardi T, Chen X, Katzenellenbogen JA, Hergenrother PJ, Minutolo F.ChemMedChem. 2015 Nov;10(11):1892-900. doi: 10.1002/cmdc.201500320. Epub 2015 Sep 1.PMID: 26332543

Reactive oxygen species in redox cancer therapy.Tong L, Chuang CC, Wu S, Zuo L.Cancer Lett. 2015 Oct 10;367(1):18-25. doi: 10.1016/j.can-let.2015.07.008. Epub 2015 Jul 14. Review.PMID: 26187782

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.Stout MB, Swindell WR, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM.Oncotarget. 2015 Sep 29;6(29):26702-15. doi: 10.18632/oncotar-get.5760.PMID: 26436954

Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence.Comisford R, Lubbers ER, Householder LA, Suer O, Tchkonia T, Kirkland JL, List EO, Kopchick JJ, Berryman DE.Gerontology. 2015 Sep 16. [Epub ahead of print]PMID: 26372907

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.

HIGHLIGHTS Postdocs from EBI Publication List

National Postdoc Appreciation Week was the week of September 21st, 2015. In honor of that week, we’d like to highlight our Postdocs from EBI.

From left to right: Haotong Chen,Yanrong Qian, Lingying Tong, Hyun Young Park, Kentaro Oki.

Cordoba-Chacon J, Majumdar N, List EO, Diaz-Ruiz A, Frank SJ, Manzano A, Bartrons R, Puchowicz M, Kopchick JJ, Kineman RD.Diabetes. 2015 Sep;64(9):3093-103. doi: 10.2337/db15-0370. Epub 2015 May 26.PMID: 26015548

Interventions to Slow Aging in Humans: Are We Ready?Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22.PMID: 25902704

Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.Sadagurski M, Landeryou T, Cady G, Kopchick JJ, List EO, Berryman DE, Bartke A, Miller RA.Aging Cell. 2015 Aug 12. doi: 10.1111/acel.12382. [Epub ahead of print]PMID: 26268661

A proteomic approach to obesity and type 2 diabetes.López-Villar E, Martos-Moreno GÁ, Chowen JA, Okada S, Kop-chick JJ, Argente J.J Cell Mol Med. 2015 Jul;19(7):1455-70. doi: 10.1111/jcmm.12600. Epub 2015 May 9.PMID: 25960181

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.List EO, Berryman DE, Ikeno Y, Hubbard GB, Funk K, Comisford R, Young JA, Stout MB, Tchkonia T, Masternak MM, Bartke A, Kirkland JL, Miller RA, Kopchick JJ.Aging (Albany NY). 2015 Jul;7(7):500-12.PMID: 26233957

GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells.Olarescu NC, Berryman DE, Householder LA, Lubbers ER, List EO, Benencia F, Kopchick JJ, Bollerslev J.J Endocrinol. 2015 Jul;226(1):13-23. doi: 10.1530/JOE-15-0012. Epub 2015 May 5.PMID: 25943560

Do altered energy metabolism or spontaneous locomotion ‘medi-ate’ decelerated senescence?Arum O, Dawson JA, Smith DL Jr, Kopchick JJ, Allison DB, Bartke A.Aging Cell. 2015 Jun;14(3):483-90. doi: 10.1111/acel.12318. Epub 2015 Feb 26.PMID: 25720347

Lessons learned from studies with the growth hormone receptor.Kopchick JJ.Growth Horm IGF Res. 2015 Jun 3. pii: S1096-6374(15)30005-8. doi: 10.1016/j.ghir.2015.06.003. [Epub ahead of print] Review.PMID: 26216709

The forgotten lactogenic activity of growth hormone: important implications for rodent studies.Bartke A, Kopchick JJ.Endocrinology. 2015 May;156(5):1620-2. doi: 10.1210/en.2015-1097. Epub 2015 Mar 2.PMID: 25730109

Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.Benencia F, Harshman S, Duran-Ortiz S, Lubbers ER, List EO, Householder L, Al-Naeeli M, Liang X, Welch L, Kopchick JJ, Ber-ryman DE.Endocrinology. 2015 May;156(5):1794-803. doi: 10.1210/en.2014-1794. Epub 2014 Dec 18.PMID: 25521584

Glucose- and triglyceride-lowering dietary penta-O-galloyl-a-D-glucose reduces expression of PPARγ, C/EBPα, and induces p21-mediated G1 phase cell cycle arrest and inhibits adipogenesis in 3T3-L1 preadipocytes. Liu X, Malki A, Cao Y, Li Y, Qian Y, Wang X, Chen X. Exp Clin Endo Diabet 2015 May;123(5):308-16. doi: 10.1055/s-0035-1548789. Epub 2015 May 19. PMID: 25988880

Glucose and Fat Metabolism in Acromegaly: From Mice Models to Patient Care.Dal J, List EO, Jørgensen JO, Berryman DE.Neuroendocrinology. 2015 Apr 29. [Epub ahead of print]PMID: 25925240

Postdocs from EBIPublication List HIGHLIGHTS Postdocs from EBI

Publication List



HIGHLIGHTS Postdocs from EBIPublication List

Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength.Lim SV, Marenzana M, Hopkinson M, List EO, Kopchick JJ, Pereira M, Javaheri B, Roux JP, Chavassieux P, Korbonits M, Chenu C.Endocrinology. 2015 Apr;156(4):1362-71. doi: 10.1210/en.2014-1572. Epub 2015 Feb 3.PMID: 25646711

Growth hormone treatment for childhood short stature and risk of stroke in early adulthood.Geffner ME, Santen R, Kopchick J.Neurology. 2015 Mar 10;84(10):1062-3. No abstract available.PMID: 25914916

Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.Zawada I, Masternak MM, List EO, Stout MB, Berryman DE, Lewinski A, Kopchick JJ, Bartke A, Karbownik-Lewinska M, Gesing A.Aging (Albany NY). 2015 Mar;7(3):195-204.PMID: 25855408

Role of Bmi-1 in regulation of ionizing irradiation-induced epitheli-al-mesenchymal transition and migration of breast cancer cells.Yuan W, Yuan Y, Zhang T, Wu S.PLoS One. 2015 Mar 3;10(3):e0118799. doi: 10.1371/journal.pone.0118799. eCollection 2015.PMID: 25734775

Inflammatory and Glutamatergic Homeostasis Are Involved in Suc-cessful Aging.Hascup ER, Wang F, Kopchick JJ, Bartke A.J Gerontol A Biol Sci Med Sci. 2015 Feb 22. pii: glv010. [Epub ahead of print]PMID: 5711529

Serum proteomic changes after randomized prolonged erythropoietin treatment and/or endurance training: detection of novel biomarkers.Christensen B, Ludvigsen M, Nellemann B, Kopchick JJ, Honoré B, Jørgensen JO.PLoS One. 2015 Feb 13;10(2):e0117119. doi: 10.1371/journal.pone.0117119. eCollection 2015.PMID: 25679398

Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.Dominick G, Berryman DE, List EO, Kopchick JJ, Li X, Miller RA, Garcia GG.Endocrinology. 2015 Feb;156(2):565-75. doi: 10.1210/en.2014-1690. Epub 2014 Dec 2.PMID: 25456069

Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet.Yang T, Householder LA, Lubbers ER, List EO, Troike K, Vesel C, Duran-Ortiz S, Kopchick JJ, Berryman DE.Endocrinology. 2015 Feb;156(2):555-64. doi: 10.1210/en.2014-1617. Epub 2014 Nov 18.PMID: 25406017

The Warburg effect: evolving interpretations of an established concept.Chen X, Qian Y, Wu S.Free Radic Biol Med. 2015 Feb;79:253-63. doi: 10.1016/j.freerad-biomed.2014.08.027. Epub 2014 Sep 30. Review.PMID: 25277420

Therapeutic microRNAs targeting the NF-kappa B signaling circuits of cancers.Tong L, Yuan Y, Wu S.Adv Drug Deliv Rev. 2015 Jan;81:1-15. doi: 10.1016/j.addr.2014.09.004. Epub 2014 Sep 16. Review.PMID: 25220353

Expression of apoptosis-related genes in liver-specific growth hor-mone receptor gene-disrupted mice is sex dependent.Gesing A, Wang F, List EO, Berryman DE, Masternak MM, Lewinski A, Karbownik-Lewinska M, Kopchick JJ, Bartke A.J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):44-52. doi: 10.1093/gerona/glu008. Epub 2014 Feb 18.PMID: 24550353

ROS and p53 in regulation of UVB-induced HDM2 alternative splicing.Tong L, Wu S.Photochem Photobiol. 2015 Jan-Feb;91(1):221-4. doi: 10.1111/php.12306. Epub 2014 Jul 26.PMID: 24986024

edison biotechnology institute newsletter - ohio university · 2019-08-06 · the report, which was...

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