UGent contribution to PolExGene(WP 3)
PolExGene Midterm meetingGhent 17-18/12/2007
PBM-GGentent
UU
Polymer Chemistry & Biomaterials GroupPolymer Chemistry & Biomaterials Group
S. Van Vlierberghe, V. Vermeersch, P. Dubruel & E. Schacht
Overview
• Workpackage content
• Work Performed
• Ongoing & future plans
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 2
Workpackage Content
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 3
Workpackage 3:Development of CIP containing polymer membranes
Development of polymer membranes by solvent-casting and electrospinning
Characterisation through AFM, SEM, XPS, ATR-FTIR, TOF-SIMS
Polyimide modification (1st approach)
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 4
O
O
N
O
O
N
n
O
NH
H2N+
O
O
HN
O
O
NH
n
NH
HNO
HN
HNO
Gel NH2 + H2C C
CH3
C
O
O C
O
C
CH3
CH2 Gel NH C
O
C
CH2
CH3
+ Gel Gel
Gel
Gel+ Irgacure + UV
PI
aminopropylmethacrylamide
gel-MOD
MeOH, 21°C
5 w/v%
gel
ATR-IR spectroscopy
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 5
20
30
40
50
60
70
80
90
100
110
120
5001000150020002500300035004000
Wavenumber (cm-1)
%T
ran
smit
tan
ce
PIPI + gel-MODgel-MOD
Imide C=O asymmetric stretch at 1771 cm-1
Imide C=O symmetric stretch at 1703 cm-1
Imide C-N stretch at 1353 cm-1
• Characteristic peaks of gel-MOD: 1556 cm-1
1665 cm-1
3274 cm-1
ATR-IR spectroscopy
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 6
1556 cm-1 1664 cm-1 3274 cm-1
gel-MOD is grafted on the PI membrane
PI + // + gel-MOD
Atomic Force Microscopy
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 7
PI, 0.54 nm PI + //, 3.52 nm
PI + gel-MOD, 0.92 nm PI + gel-MOD, 0.92 nm
X-ray Photoelectron Spectroscopy
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 8
PI PI + //
C 79% 74%
N 5% 7%
O 16% 19%O
O
HN
O
O
NH
n
NH
HNO
HN
HNO
PI
PI + //
Polyimide modification (2nd approach)
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 9
succinimidyl ester of 4-azido-2,3,5,6-tetrafluorobenzoic acid (AFB) (5 mg/ml, in ethyl acetate)
N3
FF
FF
C
O
O
N
O
O+F
F
F
F
C
OON
O
O
F
F
F
F
C
OON
O
O
(5 w/v%, pH 8)
ATR-IR spectroscopy
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 10
1556 cm-1 1664 cm-1
gelatin is grafted on the PI membrane
PI + AFB + gel
Atomic Force Microscopy
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 11
PI, 0.54 nm PI + AFB, 3.26 nm
PI + AFB + gel, 1.93 nm PI + AFB + gel, 1.93 nm
X-ray Photoelectron Spectroscopy
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 12
PI PI + AFB PI + AFB + gel
C 79% 71% 69%
N 5% 6% 11%
O 16% 21% 19%
F 0% 1% 1%
F
F
F
F
C
OON
O
O
F
F
F
F
C
OON
O
O
PI
X-ray Photoelectron Spectroscopy
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 13
PI PI + AFB PI + AFB + gel
C 79% 71% 69%
N 5% 6% 11%
O 16% 21% 19%
F 0% 1% 1%
F
F
F
F
C
OON
O
O
F
F
F
F
C
OON
O
O
PI
Static Contact Angle Measurements
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 14
0
10
20
30
40
50
60
70
80
PI PI + // PI + // + gel-MOD
PI + N3 PI + N3 + gel
Co
nta
ct a
ng
le (
°)
SCA
hydrophilicity
• Preparation of polymer membranes based on gelatin type A (IEP = 8) (IEPgelatin B = 5).
• Preparation of polymer membranes based on gel-MOD + HA-MOD (1 – 5 w/v%) gel-MOD + CS-MOD (1 – 5 w/v%)
• PBM products sent out:Gelatin coated polyimide membranes (sent to Tübingen)
Ongoing and future plans
S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 15