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Trypanosomidae Family
4 Genera (Forms)
Leishmani
(Amastigote)Leptomonade
(Promastigote)
Trypanosoma
Trypomastigote
Critidia
(Epimastigote)
Dr.Fata/Cl12Dr.Fata/Cl12
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Genus: Trypanosoma • African Trypanosomiasis
• T.gambiens
• T.rhodesiense
• American Trypanosomiasis
• T.cruzi
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African Trypanosomiasis
Transmission: Bite of Tsetse Fly
Vector:Glossina palpalis
Glossina muristans
Reservoir:Deer,Bovine
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African Trypanosomiasis Clinical signs
Febrile stage Shiver & Fever
Malaise & Headache
Anorexia &weakness
Nocturnal sweating
Adenopathy
(winter bottom sign)
CNS stage Tiredness
Confusion & Sleepy
Sever cachexia
Puffy face & Lips
Ataxia
Kerandel’s Sign
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Dr.Fata/Tr05
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African Trypanosomiasis
Dr.Fata/Tr05
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M
African Trypanosomiasis
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African Trypanosomiasis
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Dr.Fata/Tr05
African Trypanosomiasis
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African Trypanosomiasis
Dr.Fata/Tr05
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M
African Trypanosomiasis
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African Trypanosomiasis
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• Blood Examination
• Direct smear
• Culture
• Lymph node Puncture
• Immunoserologic Tests
African Trypanosomiasis
Diagnosis
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African Trypanosomiasis
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• Diagnosis
• Blood smear
• Lymph node puncture
• Immunoserology
African Trypanosomiasis
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Trypanosoma gambiense
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Trypanosoma rhodesiense
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American Trypanosomiasis
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American Trypanosomiasis
Vector
Dr.Fata/Tr05
Triatoma
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Agent: Trypanosoma cruzi
Transmission:Wound contamination
by faeces of Reduviid bugs (Triatoma)
Vector: Triatoma infestans
Triatoma megistans
Reservoir:Armadillo
American Trypanosomiasis Chagass Disease
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American Trypanosomiasis • Acute Stage • Weakness,Shiver,Fever
• Muscular pain , Epistaxy
• Progressive tiredness
• Lymphadenopathy
• Hepatosplenomegaly
• Chagoma(Rommana sign)
• Oculoglandular syndrom
• Chronic Stage
• CNS involvement
• Myocarditis
• Megaoesophagus
• Megacolon
• Death
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American Trypanosomiasis
• Diagnosis
• Blood smear
• Lymph node puncture
• Immunoserology
• Xenodiagnosis
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American Trypanosomiasis
•Chagoma(Rommana sign)
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American Trypanosomiasis
Chest X.Ray
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American Trypanosomiasis •Chagoma(Rommana sign)
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Diagnosis
• Blood smear
• Blood culture in NNN
• Immunologic tests:
Elisa
IF
PCR
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TREATMENT
• GLUCANTIME