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Traumatic Brain Injury and Other Brain Disorders
• Billie A Schultz, MD is a Consultant in the Department of Physical Medicine and Rehabilitation at the Mayo Clinic in Rochester, MN
• Dr. Schultz is an Assistant Professor in the College of Medicine.
• She is board certified in PM&R and subspecialty certified in Brain Injury Medicine
• Clinical interests include acquired brain injury and spasticity
Mayo Clinic Physical Medicine and Rehabilitation Board Review
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Traumatic Brain Injury and Other Brain Disorders Online curriculum
Billie A Schultz, MD
Physical Medicine and Rehabilitation Board Review
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Disclosures • Financial- None • Off Label usage of medications will be
discussed in management of TBI associated complications
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Objectives • Identify common TBI related symptoms and
management • Identify various presentations and interventions
of other brain related disorders including multiple sclerosis and Parkinson Disease
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Traumatic Brain injury- Definition • Injury to the brain caused by external forces
• Does not require loss of consciousness • Does not require direct impact to the head
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Cause of TBI All Ages
Falls
Motor Vehicle-TrafficViolence
Struck by/ Against
Unknown/Other
Mayo Clinic Physical Medicine and Rehabilitation Board Review
CDC, 2014
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Cause of TBI Ages 0-4
Falls
Motor Vehicle-TrafficViolence
Struck by/ Against
Unknown/Other
Mayo Clinic Physical Medicine and Rehabilitation Board Review
CDC, 2014
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Cause of TBI Ages 65 and greater
Falls
Motor Vehicle-TrafficViolence
Struck by/ Against
Unknown/Other
Mayo Clinic Physical Medicine and Rehabilitation Board Review
CDC, 2014
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Cause of TBI Ages 25-44
Falls
Motor Vehicle-TrafficViolence
Struck by/ Against
Unknown/Other
Mayo Clinic Physical Medicine and Rehabilitation Board Review
CDC, 2014
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Gender distribution of TBI based on ED visits in 2010
MenWomen
Mayo Clinic Physical Medicine and Rehabilitation Board Review
CDC, 2014
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TBI- pathophysiology • Primary Injury
• Direct result of trauma • Contusion/lacerations
• Common location of contusions • Inferior frontal lobe • Anterior temporal lobe
• Diffuse axonal injury • Common location of DAI
• Midline brain structures • Grey-white matter junctions
• Cranial nerve injury • Diffuse vascular injury • Focal intracranial hemorrhage
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TBI-pathophysiology • Secondary injury
• Includes • Intracranial
hemorrhage • Swelling/ Edema • Hypoxia • Infection • Hydrocephalus • Hypotension • Seizures • Vasospasm
• Electrolyte
imbalances • Anemia • Hyperthermia • Hyper/hypo
glycemia • Hypercarbia • Hyponatremia • Carotid dissection
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TBI- Blast injury • Primary injury
• Direct effects of the pressure (positive and negative) waves
• Secondary injury • Objects striking the person
• Tertiary injury • The person striking objects
• Quaternary injury • Associated injuries including inhalation, burns,
hypoxia
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TBI- Predictors of Outcome • Definitions
• GCS • PTA
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Glasgow Coma Scale
• Helps to define severity- best score in 24 hours
Score Motor (6) Verbal (5) Eye (4) 1 None None None 2 Extensor posturing
to pain Unintelligible Opens to pain
3 Flexor posturing to pain
Inappropriate Open to loud voice
4 Withdraws from pain
Confused Open spontaneously
5 Localize to pain Alert/oriented 6 Obey commands
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Glasgow Coma Scale • 3-8- severe injury • 9-12- moderate injury • 13-15- mild injury
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GCS as a predictor of outcome • Best motor response is best predictor • Total score predicting • Recent evidence indicates this may not predict
as well as previously thought.
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Post traumatic amnesia
• Galveston Orientation and Amnesia Test (GOAT) • Assessed orientation, recall of circumstances, last pre-
injury and first post injury memories • 75 or greater for 2 consecutive days is end of PTA
Duration of PTA Severity of Injury Category
< 5 minutes Very mild 5-60 minutes Mild 1-24 hours Moderate 1-7 days Severe 1-4 weeks Very severe > 4 weeks Extremely severe
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TBI- Other predictors • Imaging • Age • Pupillary reaction • SSEPs • Doll’s eye sign • Caloric testing • Motor response to pain • Time
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TBI- outcome scales • Glasgow Outcome Scale
• 1-5 (1=death; 5=good recovery) • Disability Rating Scale
• 30 point scale (measures eye opening, verbalization/communication, motor responsiveness, feeding, toileting, grooming, overall level of functioning, employability)
• Functional Independence Measure (FIM) • 18-126 (cognitive and motor domains)
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TBI - Disorders of Consciousness Sleep/wake cycles
Eye opening
Visual tracking
Evidence of environmental awareness
Consistent command following
Functional object use/ use of a communication system
Coma No No No No No No Vegetative state
Yes Yes No No No No
Minimal conscious state
Yes Yes Yes Yes No No
Emergence Yes Yes Yes Yes Yes Yes
Response to
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TBI- Rancho Los Amigos Level Description I No response II Generalized response III Localized response IV Agitated V Confused and inappropriate VI Confused and appropriate VII Automatic and appropriate VIII Purposeful and appropriate
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Neuropsychological testing • Assess cognitive and emotional issues which
may affect function.
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Functional limitations secondary to TBI • Motor
• Impaired mobility • Impaired ADLs
• Behavior • Agitation • Disinhibition • Emotional lability • Abulia
• Social/cognitive • Return to work, school • Need for cognitive
supervision • Return to driving
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Management of TBI associated complications
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TBI- arousal • Sleep wake regulation • Fatigue • Medication options
• Stimulants • Dopaminergic agents
Giancino, 2012
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Post traumatic agitation • Excessive psychomotor activity • Evaluate for underlying etiology • Education • Treatment
• Nonpharmacologic • Pharmacologic
• Monitor results of intervention
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Treatment of post-traumatic agitation
Non-pharmacologic
• Environmental modification
• Education of staff/family
• Behavior modifications
Pharmacologic
• Beta-blockers
• Anti-convulsants
• Anti-psychotics
• Antidepressants
• Neuro-stimulants
• Dopaminergic agents
• Benzodiazepines
• Lithium
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Post Traumatic Hydrocephalus • True hydrocephalus vs. ex vacuo changes • Symptoms
• Cognitive changes • Gait dysfunction • Urinary incontinence
• Evaluation • Imaging- CT head
• Treatment • Lumbar puncture • Shunting
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Heterotopic Ossification • Formation of mature bone in soft tissue • Risks- neurologic injury, trauma, surgery, burns • Symptoms- pain, warmth, limited joint ROM • Evaluation- Triple phase bone scan • Treatment- physical therapy, NSAIDs,
bisphosphonates, radiation, surgery
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Thromboembolic Disease • Risks- Virchow triad • Symptoms-
• DVT- none, fever, edema, warmth, pain • PE- none, chest pain, tachypnea/-cardia, hypoxia
• Evaluation- • DVT- venous US • PE- CT angio, VQ scan
• Treatment- • Anticoagulation, mechanical thrombectomy or
thrombolysis in select cases.
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Post-traumatic Epilepsy/seizures • Immediate vs. early vs. late seizures • Risk factors • Prophylaxis • Treatment
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Urinary dysfunction • Covered in detail elsewhere • Specific to brain injury
• Cortical lesions • Loss of inhibition
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Endocrine complications • SIADH • Cerebral salt wasting • Diabetes Insipidus
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SIADH DI CSW Fluid status Iso Iso (if able to match
fluids in/out) Dry
Sodium (serum) Low High Low Osmolality (serum) Low High Low Osmolality (urine) High Low Normal Treatment Fluid
restriction Desmopressin Fluid
supplementation
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Spasticity • Upper motor neuron mediated velocity-
dependent increase in muscle tone • Examination- quantify spasticity • Treatment should be goal oriented • Treatment
• Stretching, splints and braces • Oral medications • Chemo-denervation • Intrathecal therapy • Surgery
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Cognitive Rehabilitation • Focuses on difficulties with attention, learning or
memory, executive functioning • Remediation • Compensation
Cicerone, 2011
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Mild TBI and concussion • Definition
• GCS 13-15 • +/- LOC (if present not to exceed 30 minutes) • PTA not exceeding 24 hours • Complicated if intracranial imaging findings on CT
day of injury
• Diagnosis • Clinical based on symptoms and exam
• Sideline testing • IMPACT and similar neuropsychologic profiles
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Return to Play- concussion
Stage Activity 0-no activity (symptomatic) Cognitive/physical rest 1- light aerobic Intensity less than 70%; no
resistance training 2- sport-specific exercise Drills, no head impact activities 3- noncontact training drills More complex training drills,
progressive resistance training 4- Full-contact practice Participate in normal training 5- Return to play Normal game play
McCrory, 2013
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Post-concussive syndrome • Multi-disciplinary approach
• Education • Symptom management
• Cognitive rehabilitation • Psychology/psychiatry • Headache/pain management • Sleep assessment/management • Vestibular rehabilitation • Vocational rehabilitation • Educational assistance
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Chronic Traumatic Encephalopathy • Tauopathy of uncertain incidence, etiology and
clinical significance
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Parkinson Disease • Cause- loss of substantia nigra pars compacta
(produces dopamine) and presence of Lewy bodies
• Symptoms • Rest tremor* • Bradykinesia* • Rigidity* • Hypophonia • Micrographia
• Parkinson Plus
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Parkinson Plus Lewy Body Dementia
Progressive Supranuclear Palsy
Multiple System Atrophy
Corticobasal Degeneration
• Motor symptoms of PD
• Dementia (progressive)
• Visual hallucinations
• Motor symptoms of PD
• Decreased vertical gaze
• Bradykinesia • Rigidity • Ataxia • Autonomic
dysfunction
• Bradykinesia • Rigidity • Apraxia • Alien limb
syndrome
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Parkinson Disease • A clinical diagnosis • Other associated symptoms/complications
• Dysphagia • Pain • Sexual dysfunction • Depression • Pulmonary dysfunction • Orthostasis
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Medical treatment of Parkinson Disease • Medications
• Anticholinergic • Antiviral • Dopamine replacement • Dopamine agonist • Selective dopamine agonist • MAO B inhibitors • COMT inhibitors
• Surgical • Deep brain stimulator
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Rehabilitation treatment of Parkinson Disease • Goals- improve muscle strength, mobility and
function • Gait training • Assessment of ADLs with adaptive
techniques/equipment • Speech pathology • Dysphagia assessment
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Multiple Sclerosis • Inflammatory demyelinating disorder • 4 types
• Relapsing-remitting • Secondary progressive • Primary progressive • Progressive relapsing
• Diagnosis • Imaging • Clinical symptoms • Positive CSF
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Multiple Sclerosis- symptoms
• Vision
• Sensory symptoms
• Motor symptoms
• Neurogenic bowel
• Neurogenic bladder
• Fatigue
• Sexual dysfunction
• Cranial nerve involvement
• Cerebellar symptoms
• Cognitive changes
• Mood disorders
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Multiple Sclerosis- Medical Treatment • Treat the disease
• Immunomodulatory drugs • Antiproliferative drugs • Block extracellular processes
• Treat the symptoms • Spasticity • Fatigue • Pain • Neurogenic bladder/bowel • Mobility
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Multiple Sclerosis- rehabilitation treatment • Dependent on symptoms • Goals- decrease spasticity, improve mobility,
improve function • Physical therapy • Occupational therapy • Speech and language pathology
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Suggested Reading material • Textbooks
• General PMR • Braddom’s • DeLisa’s • Frontera’s
• Brain Injury • Zalser’s
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References • [CDC | TBI Data and Statistics | Traumatic Brain Injury | Injury Center.
(2014, February 24). Retrieved September 21, 2015, from http://www.cdc.gov/traumaticbraininjury/data/index.html
• Giacino, J. T., Whyte, J., Bagiella, E., Kalmar, K., Childs, N., Khademi, A., . . . Eifert, B. (2012). Placebo-Controlled Trial of Amantadine for Severe Traumatic Brain Injury. N Engl J Med, 366(9), 819-826.
• Cicerone, K., Langenbahn, D., Braden, C., Malec, J., Kalmar, K., Fraas, M., . . . Ashman, T. (2011). Evidence-Based Cognitive Rehabilitation: Updated Review of the Literature From 2003 Through 2008. Archives of Physical Medicine and Rehabilitation, 92, 519-530.
• McCrory, P., Meeuwisse, W., Aubry, M., Cantu, B., Dvorak, J., Echemendia, R., . . . Engebretsen, L. (2013). Consensus statement on Concussion in Sport- The 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med, 47(5), 250-258.
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Mayo Clinic Physical Medicine and Rehabilitation Board Review
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