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Transplantation Immunology
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Autologous (autograft): from one individual to the same individual
Syngenic: between two genetically identical or syngeneic individuals
Allogenic (allograft): between two genetically different individuals of the same species
Xenogenic (xenograft): between two genetically different individuals of different species
Grafts
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Genetics of graft rejection
Rejection is causedby MHC antigens
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First-set and second-set rejection
Rejection is mediatedby lymphocytes
AB
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Rejection of skin grafts
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Direct and indirect presentation of MHC alloantigens
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Direct alloantigen recognition
Positive selection in the thymus allows all T lymphocytesthat recognize MHC molecules to survive.Negative selection eliminates T lymphocytes with strongaffinity for self-MHC molecules, but T lymhocytes withstrong affinity for non-self (allo) MHC molecules survive
High frequency of allo-reactive T lymphocytes (~2%)
Each allogenic cell can activate many T lymphocyte clones
Density of alloantigens is higher than self-MHC/antigens
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Mixed leucocyte reaction
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Hyperacute and acute rejection
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Chronic rejection
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Minor Histocompatibility Antigens (H)
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Graft-versus-host-disease (GVDH)
Caused by the donor T lymphocytes after bone-marrow transplantation,but also after transplantation of organs that contain T lymphocytes
Acute GVHD: skin, liver, gastrointestinal tract (rash, jaundice, diarrhea)
Chronic GVDH: organ fibrosis and dysfunction