The POWER of Cranberry seed extract

together with the super-antioxidant

AstaXanthin

Benefits of Taking AstaCran®

Advantages of AstaCran® AstaCran® has extremely good stability

NO harmful solvent residues

Flaxseed and fish oils have a very short shelf life

These oils actually become rancid in short time and can (in some cases) become carcinogenic

No other supplement provides such a balanced ratio of essential fatty acids

AstaCran ® is derived from highly-renewable and safe sources

Advantages of AstaCran®1. Source of balanced EFA’s2. Super Antioxidant3. Aids in maintaining cardiovascular health4. Aids with cholesterol management5. Protects skin and eyes from photic injury6. Reduce risk factors associated with macular

degeneration7. “Anti-Aging” properties via reduction of oxidative

stress8. Balanced EFA’s and super antioxidant in a single

dose (Savings $$)

AstaCran®

Cranberol™

Cranberry seed extract

Zanthin™

Astaxanthin complex

Cranberol™

Cranberry seed extract

Cranberry seeds

Supercritical CO2 extraction method

• NO harmful solvent residues

High amounts of Essential Fatty Acids (EFA’s)

Omega-3 and Omega-6

Also possesses antioxidants

High levels of Phytosterols

Cranberries Vaccinium

macrocarpon

Cranberry Seed Extract

Super Critical CO2 extraction

Extraction performed under high

pressure using CO2 as a solvent

When extraction is complete, CO2 gas leaves NO residue (This may not be true with other commonly used solvents)

• This is an exception, not the standard

Highly sustainable source of a balanced ratio of Essential Fatty Acids (EFAs)

Essential Fatty Acids

Polyunsaturated Fatty Acids(PUFAs) “double bond”

Omega-3 and Omega-6

Essential because your body doesnot produce them. Acquired from diet or food supplements

Nutritionists have found that a balanced Omega-6/Omega-3 ratio of 1:1 is best for optimal health

EFA’s – Omega-6 & Omega-3 The current western diet:

15:1 and higher ratio

Recommended dietary ratio: Between 5:1 and 10:1 1:1 ratio in humans is

ideal

The best supplemental source should have as close to a 1:1 ratio as possible

Omega-6

Linoleic acid (LA) Most commonly produced Essential

Fatty Acid in agricultural seed oil production Majority intake from vegetable oils

Highly unbalanced amounts of LA are bad because they promote inflammation, which can lead to many health problems

Primarily beneficial when in balance with Omega-3’s Alpha-Linoleic Acids (ALAs)

This converts in the body to gamma-Linolenic acid (GLA) and then to prostaglandins that help regulate inflammation and blood pressure, as well as heart functioning.

Omega-3

ά Linolenic acid (ALA)

High concentrations of Omega-3 improves vitality of the skin

Absorption is enhanced when combined with Omega-6

As our diets have changed, Omega-3 consumption has decreased to a ratio that is associated with degenerative conditions

Omega-3 helps reduce LDL cholesterol

Other Sources Other EFA sources

Fish and shellfish

Flaxseed (linseed)

Canola oil, hemp oil, soya oil

Chia seeds, pumpkin seeds, sunflower seeds

Leafy vegetables and walnuts

AstaCran can replace ALL other supplemental EFA sources (BIG savings)

Cranberol™ Antioxidants

Tocopherols

Vitamin E family

Powerful antioxidant

Tocotrienols

Also a form of Vitamin E

40-60x stronger than tocopherols as an antioxidant

What is an Antioxidant? An·ti·ox·i·dant

A substance (as beta-carotene or vitamin C) that inhibits oxidation or reactions promoted by oxygen, peroxides, or free radicals.

Merriam-Webster Online

It gives, takes, or traps an electron.

Phytosterols play an important role in maintaining a healthy cholesterol level

Reduces cholesterol absorption in the intestines

Similar chemical structures that compete with cholesterol for absorption.

Significant for cardiovascular health

Beta-sitosterol

Helps reduce blood levels of cholesterol Stigmasterol

Phytosterols

Cholesterol

Low Density Lipoproteins (LDL)

So called “Bad” cholesterol.

Transports cholesterol into the arteries.

High Density Lipoproteins (HDL)

So called “Good” cholesterol

Suspected to carry cholesterol from within* arteries to liver for redistribution or expulsion

*ath·er·o·ma - 1:  Fatty degeneration of the inner coat of the arteries 2:  An abnormal fatty deposit in an artery

Merriam-Webster Online

Cranberol™

Cranberol can aid and supporta healthy cardiovascular system

Aid in maintaining healthy cholesterol levels

Aid in reduction of oxidative stress

Desirable source for a balanced ratio of EFA’s

Doesn’t turn rancid like many other sources of EFA’s

Zanthin®

Astaxanthin complex Super-antioxidant

Prevents oxidative damage 418g Atlantic Salmon = 3mg of astaxanthin.

(1 pound = 453.59237 grams)

Fish is becoming less desirable as a source for necessary compounds due to a concern over the rising levels of mercury, and various other heavy metals.

Source of Zanthin® Haematococcus microalgae

Haematococcus pluvialis – Unicellular green algae– Found in Freshwater bodies

Distribution of Astaxanthin stereo isomers in selected organisms (Bjerkeng1997)

SPECIES (3S,3’S) (3R,3’R) & (3R,3’S)

(3R,3’R)

Yeast (Phaffia sp.) --- <2% >98%

Micro algae (Haematococcus)

100% --- ---

Synthetic Astaxanthin (Carophyll Pink La Roche)

25% 50% 25%

Atlantic Salmon 78-85% 2-6% 12-17%(Schiedt et al 1981)cited in Foss 1984

Haematococcus Pluvialis

Potent source of astaxanthin Highly renewable Safe Grown in a controlled environment

Other Sources Abundant in Nature (in water) Found in Salmon, Trout, Crustaceans, Crawfish,Pacific Cod, Scallops, Mackerel,

Flounder, and other commercial seafood

Renewable

Species Content (mg/kg)

Sockeye Salmon 26-37Atlantic Salmon 3-11Krill 46-130

Astaxanthin Concentration

Species Amount of

Astaxanthin present per Kilogram

Atlantic Salmon 3 - 11mg

Sockeye Salmon 26 - 37mg

Rainbow Trout 1 - 13mg

Yeast (Phaffia sp.) 30 - 800mg

Algae (Haematococcus pluvialis)

10,000 - 30,000mg

Zanthin® Astaxanthin

Super-antioxidant

Properties of Astaxanthin Decreased DNA damage. Arrests mitochondrial free radicals

Powerful Antioxidant Crosses blood-retina barrier

Immune-modulatory activity Provides anti-inflammatory activity

Increases strength and endurance

Protects eyes and skin from photic injury

Antioxidant Studies

Anti Oxidant Studies

Naguib, Y., "Antioxidant Activities of Astaxanthin and Related Carotenoids,"Journal of Agricultural and Chemistry, v.48 (4), pp. 1150-1154.

ORAC Values of Antioxidants

0

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6

astaZanthin™Standardized

Extract

NaturalLycopene

SyntheticAstaxanthin

Natural alpha-tocopherol

Natural a-bCarotene mix

NaturalTocotrenols

Natural Lutein Natural beta-Carotene

OR

AC

Va

lue

pe

r u

nit

ac

tiv

e

ORAC – Oxygen Radical Absorbance Capacity

AstaZanthin™ Standardized ExtractNatural LycopeneSynthetic AstaxanthinNatural alpha-tocopherolNatural a-b Carotene mixNatural TocotrienolsNatural LuteinNatural Beta Carotene

1.3800.5960.4190.3810.3450.3180.2800.242

Astaxanthin

Astaxanthin was 10 - 50 times stronger than vitamin E in the lipid peroxidation of mitochondria membranes using the TBA method Inoue (1990)

Astaxanthin is 10 times stronger than zeaxanthin, lutein, beta-carotene and canthaxanthin

Astaxanthin is 100 times greater than alpha-tocopherol against active oxygen species in the thiobarbituric assay

Miki (1991)

Strength and Endurance Fitness (submaximum load – Astrand method)

Strength/Explosivity (Wingate method of maximum effort)

Endurance (knee-bending technique) Malmsted, C.L. Gustavsberg,

Sweden

“Dietary Supplement with Astaxanthin-Rich Algal Meal Improves Muscle Endurance - A Double-blind Study on Male Students” N=40

6 Month Treatment Pre-treatment

standardized exercise tests/endurance

(p<0.05)

Significant Improvement in strength/endurance

(p<0.05)

Strength and Endurance

Increased Carotenoid content