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SLIDE SEMINAR 6‐BREAST
CASECASE
Assist.Prof.Dr. Özgür İLHAN ÇELİK
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CASECASE
• 45 year‐old female patient has a mass with a diameter of 1 cm, on upper outer quadrant of pp qher right breast.
• Mammography: A spiculated solid mass;• Mammography: A spiculated, solid mass;
BI‐RADS 3 lesion (Breast Imaging Reporting
and Data System)
F il Hi t P t• Family History: Present
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Cytology of the fine needle aspirationmaterial
• Very cellular slides
• Background: some erytrocytes, macrophages and nakedl i f ith li l llnuclei of myoepithelial cells
• Normal groups composed of ductal epithelial andmyoepithelial cellsmyoepithelial cells
• 2‐3 dimensional large groups, composed of atypical epithelialcells with large hyperchromatic pleomorphic eccentriccells with large, hyperchromatic, pleomorphic, eccentriclocalized nucleus, some of which have eosinophilic, columnarcytoplasm, mixed with myoepithelial cells
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Cytology of the fine needle aspirationmaterial
• DIAGNOSIS: Suspicious cytology
• NOTE: This cytopathology can be considered as y p gy‘Atypical proliferative epithelial lesion (Atypicalductal hyperplasia, carcinoma in situ??)ductal hyperplasia, carcinoma in situ??) accompanying with columnar cell change
A h h d f il hi t f b t i it• As she had a family history of breast carcinoma; it will be appropriate to excise the mass.
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Histopathology of the excision material
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Smooth Muscle Actin stain showing myoepithelial cell layer
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DIAGNOSISDIAGNOSIS
SCLEROSING ADENOSIS associated withATYPICAL COLUMNAR CELL HYPERPLASIAATYPICAL COLUMNAR CELL HYPERPLASIA