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Sex, guts and healthy bones
Laura McCabe, Ph.D.Departments of Physiology and Radiology
February 26, 2016
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Sex, guts and healthy bones
Laura McCabe, Ph.D.Departments of Physiology and Radiology, MSU
Inflammation
GEORGE
JEN
Intestinal TNF
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IL-10 -/-
♂ ♀
Adult mice
MALE FEMALE
Sex determines intestinal and bone responses to “bad” bacteria
H. Hepaticus
Bone
den
sity
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Bon
e D
ensi
ty
Intestinal Inflammation is Linked to Bone Loss
Colon TNFa levels
r = -0.79p < 0.0001
0 1 2 3 4 5 6 7 8 9 100
30
60
Intestinal Pathology Score
r = -0.76p = 0.002
0 12 240
30
60
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• In milk, meat, human gut• Used to treat colic• Produces anti-microbials• Anti-inflammatory activity
0
8
16
24
32
MA
LE B
one
dens
ity
*
Control +Lr
*47%
MAL
E In
testi
nal
TNFα
/HPR
T
co n tro l lacto
0
0.2
0.4
0.6
0.8
1
Control +Lr Control ↓E ↓E+Lr
Verte
brae
0
10
20
FE
MAL
EBo
ne d
ensit
y
Lactobacillus reuteri (LR):
Sex determines intestinal and bone responses to “good” bacteria
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Inflammation
Immune cells
Bacteria + products
Blood
Inte
stin
alEp
ithel
ial B
arrie
r
Tightjunctions
Gut environment modulators:
Probiotics, Prebiotics, Antibiotics, New Compounds
Other signals:Incretins, Serotonin,
Neural,Distal Inflammation
Working Model
Bone marrow