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Rudy Dekeyser
21/04/05
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• origin of the species
• mission & objectives
• creating an innovative environment
• is basic high quality research compatible with tech transfer?
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• origin of the species
• mission & objectives
• creating an innovative environment
• is basic high quality research compatible with tech transfer?
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Origin of the species
Ghent
Antwerp
Louvain
Diepenbeek
Brussels
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Origin of the species
Step 1. Flemish government evaluates the life sciences research [1994]
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Origin of the species
The 1994 conclusions: big names in science
but lack of structural support critical mass translation in industrial activities
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Origin of the species
Dedicate a certain volume of an existing granting body to life sciences research danger:
slice it thin lack of sustainability
Establish a novel independent research institution
danger: disturb the equilibrium lag phase
The conventional approach:
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Origin of the species
Step 2. The VIB concept
unite existing quality build synergy and critical mass
researchtech transfer
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Origin of the species
VIB – unite existing quality
60 biotech teams in 5 universities
evaluation
select 9 excellent teams
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Origin of the species
U2 U3
U4 U5
U1
VIB vzw
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Origin of the species
VIB – create critical mass
Flemish government invests 5y x 25M€ = 125.000.000 €
= doubling research budget overnight= creating critical mass
Framework agreement:• long term commitment • in depth evaluation every 5 year
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Origin of the species
VIB – create synergy
Framework agreement with universities key output: scientific publications
www.nature.com/reviews/genetics
752 / October 2004 / volume 5
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Origin of the species
VIB – create synergy
Framework agreement with universities tech transfer:
• IPR– joint ownership– management: VIB– costs: VIB
• marketing/exploitation: VIB
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Origin of the speciesVIB – create synergy Framework agreement with universities
tech transfer - return
€ € €patent cost
inventors VIB
50 univ 50 VIB
Department
40 401010
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Origin of the species
VIB – create synergy
Framework agreement with universities tech transfer – return
UNIV : 10 + 40 + 40 = 90%
VIB : 10 + 40 + 40 = 90%
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Origin of the species
VIB – key facts & figures
foundation : 1996 legal entity : not-for-profit field : life sciences budget 2004 : ~ 60 mio € headcount : ~ 850
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• origin of the species
• mission & objectives
• creating an innovative environment
• is basic high quality research compatible with tech transfer?
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Mission
Molecular sciences to improve the quality of life
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Objectives
conduct frontline basic research
translate inventions into products for the benefit of society
inform the public
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• origin of the species
• mission & objectives
• creating an innovative environment
• is basic high quality research compatible with tech transfer?
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VIB - Research
Major fields: Oncology Cardiovascular/angiogenesis Neurobiology Inflammation/immunology Developmental biology Plant system biology Microbiology
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TNF-R55
TNFmembrane
VIB - Research
p50 p65IB
p50 p65
IBUb
UbUb
PP
nucleus
p50 p65NF-B dependent genes
TNF-R75
FADD
casp8
apoptosis PP
IKK
IKK/ IKK /
MAP3K
TRADD
TRAF2
PP
inflammation
Ub
RIP
ABIN
A20
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VIB - Research
healthy colon
Colitis ulcerosa Crohn’s disease
Recombinant L.lactis, expressing IL-10
Novel treatment for IBD in clinical trial
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VIB - Research
2 3 4 5 6 7 81
Cleavage
mRNA
gDNA
CTG1(-540)
ATG(1)
-1154-2578
-634G/CVEGF189
L-VEGFProtein
G/A
C/A
G/C
VEGF mice show adult onset ALS phenotype
Reduced levels of VEGF increase the risk for ALS
VEGF promoter polymorphisms reduce VEGF expression
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H
16OArg
N
ArcN
C16O
H
C18O
18O
Ex.: Heatmap of ratios of amino-terminal peptides for 700 IDs from T-Lymphocyte
x
y
VIB - ResearchQuantitative N-teromics
According to reverse phase chromatography position
According to ratio (O18/O16)
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VIB - Research
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VIB – Tech Transfer
Tech Transfer = Technology Transfer
= Knowledge Transfer
= the movement of knowledge between different parties
= the transfer of knowledge from an academic institution to industry
= patenting, licensing and establishing start-ups
= mining of knowledge
=> optimize knowledge creation
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VIB - Research Target : frontline Create the environment:
recognise excellence
top performance => budget
low performance => budget excellence bonus recruit internationally
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39 nationalities
58% European countries
23 % Asia
11% N&S America
6,5 % Africa
1% Australia
0
10
20
30
% I
NT
Po
std
oc
s1997 1999 2001 2003
% internationalisation
VIB – Research
international recognition
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VIB - Research Target : frontline Create the environment:
recognise excellence
up to date infrastructure
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UGent-VIB research building
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VIB - Research
Target : frontline Create the environment:
recognise excellence
up to date infrastructure
access to advanced technology platforms
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VIB microarray facility
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(Source: PhD thesis Kris Gevaert, 2000)
VIB proteomics core facility
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VIB Genetic Service Facility
sequencing
STR-genotyping
SNP discovery
SNP analysis
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VIB technology – model organisms
yeast drosophila zebrafish
xenopus mouse arabidopsis
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VIB technologiesBio-informatics
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VIB - Research Target : frontline Create the environment:
Stimulate debate and interaction GLC VIB seminar VIB newsletter science clubs PhD program
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VIB - Research
Quality assurance:
• IAB
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Institutional Advisory Board 2004
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VIB - Research
Quality assurance IAB SAB strategic plan organigram [critical density]
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VIB - Research
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VIB - Research
Quality assurance
IAB SAB strategic plan organigram performance criteria
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VIB - Research
Performance criteria:
scientifically
≥ 45 publications in IF > 10 journals
≥ 125 publications in IF > 5 journals
education
≥ 35 PhD’s
tech transfer
≥ 25 patent applications
50% granted
≥ 5 mio € industry funding
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VIB - Research
X 2.7 X 3.3
IF > 10IF > 5
16
53
0
10
20
30
40
50
60
1995 2004
69
187
0
20
40
60
80
100
120
140
160
180
200
1995 2004
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• facilitate the commercialisation of research results for the benefit of society • promote economic growth• job creation• generate research € to dept.
records of invention
IPR
agreements existing
companies
start-ups
research
VIB – Tech Transfer
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VIB – Tech Transfer
Disclosure and recording of inventions
Policy: adapt to academic environment pro-active minimize administrative hurdles treat with priority
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VIB - Tech Transfer
0
10
20
30
40
50
60
96 97 98 99 2000 2001 2002 2003 2004
# ROI
Inventions
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VIB - Tech TransferROI-benchmark
3
2,5
2
1,5
1
0,5
0V IB
M €
/RO
I
Cal TechARCH
StanfordCan. Inst.
US Inst.US Univ.
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VIB - Tech Transfer
0
5
10
15
20
25
30
35
95 96 97 98 99 2000 2001 2002 2003 2004
# P A
# patent applications
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VIB - Tech Transfer
Patent applications (PA)
VIB : 48% ROI => PA
Benchmark : 50% ROI => PA
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VIB – Tech Transfer
Priority filing
EUUSUK
PCT filing
2nd filing
Search report
National phase
Written opinion
Preliminary Examination Report
Granting
portfolio management
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VIB – Tech Transfer
0
5000
10000
15000
20000
25000
30000
35000
'96 '97 '98 '99 '00 '01 '02 '03 '04
Budgets/year - cumulative
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VIB - Tech Transfer
Pfizer Novartis Johnson & Johnson Solvay Abbott Bayer
Licensing/R&D: some collaborators
Innogenetics Tibotec Galapagos CropDesign Ablynx Tigenix
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VIB - Tech Transfer
conceptualize and write business plan strengthen the technology/product base via inlicensing assist in bringing the team in place road show to raise venture money assist in the due diligence process
VIB operates in a very hands-on manner by playing the role of seed financier:
Start-up: basic principles
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VIB - Tech Transfer
Start-up: case study - nanobody
Broad application spectrum
• diagnostics/proteomics
• therapeutics
• immuno-affinity
• feed/food
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VIB - Tech Transfer
Start-up: case study – nanobody
(1) Technology building
secured access to 3 basic patents covering product claims and production methodology (VUB)
filed 6 more patent families
> 40 patent applications and patents
(2) Strategic investments:
VIB grant complemented with:
• tech transfer project
• IWT grant
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VIB - Tech Transfer
Start-up: case study – nanobody
(3) Business plan (Ablynx)(4) Attract lead investor (GIMV)(5) Establish legal entity (VIB + GIMV)(6) Attract CEO (M. Vaeck, ex-COO Ceres)(7) Ad interim management
• recruit first employees
• rent lab space
• furnish labs
• establish contacts with potential licensees
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Ablynx nv
Biopharma Foundation : 2001 Location : Ghent CEO : Dr. Mark Vaeck Venture Capital 1st round : 5 M € Investors : GIMV, BFV, Sofinnova, Gilde Venture Capital 2nd round : 25 M € New investors : Abingworth, Alta Partners
Employees : 40
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Devgen nv
Biopharma & agbio
Foundation : 1997
Location : Ghent
CEO : Dr. Thierry Bogaert
Venture Capital 1st round : 9.4 M €
Investors 1st round : GIMV, Abingworth, BVF
Venture Capital 2nd round : 29 M €
New investors : Advent, LSP, Rendex, ING, DV, KBC, M&M
Employees : 95
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CropDesign nv
Agbio Foundation : 1998 Location : Ghent CEO: : Dr. Johan Cardoen Venture Capital 1st round : 11 M USD Investors 1st round : GIMV, Atlas Venture, Sofinnova,
BFF Venture Capital 2nd round : 25.6 M € New Investors : Gilde, ING, DV, Burrill Agbio, KBC,
Technolife 2010
Employees : 70
Venture Capital 3th round : 16 M€
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Peakadilly nv
Biopharma Foundation : 2004 Location : Ghent CEO : Koen Kas Capital 1st round : VIB Income : 3 mio € Employees : 10
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Tech Transfer - 2004
0
20
40
60
80
100
120
140
160
180
200
'97 '98 '99 '00 '01 '02 '03 '04
Totaal
Start-ups: employees
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VIB start-up
Benefit for society:
multiple therapeutics under development novel agronomically improved crop varieties
under deveopment
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VIB - Tech Transfer
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Innogenetics
VIB Bio-incubator 2
VIB Bio-incubator 1
Innovation& Incubation centre 2 (University of Ghent)
Innovation & Incubation centre 1 (University of Gent)
Crop Design
Bayer Bio Science research facilities University of Ghent/VIB
DeVGen
DeVGen
Service Center for biotech
Buildings planned or under construction
Ghent Technology Park
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Conclusion
scientific output and quality improved significantly
tech transfer output has increased from almost zero to significant
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• origin of the species
• mission & objectives
• creating an innovative environment
• is basic high quality research compatible with tech transfer?
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Balancing science & Tech Transfer
science technology basic applied
Ye
arly
av
g #
pu
bs
Groups without collaboration
Groups with collaboration
Source: K. Debackere et al., in prep.
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Balancing science & Tech Transfer
Table 1a – average number of SCIE publications (1998-2000)
Inventors Non-inventors
Complete sample 35,8 11,7
Sample without outliers
(# pubs < 90)
22,8 12,1
Source: K. Debackere et al., in prep.
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Balancing science & Tech Transfer
Conclusion:
High quality basic science & tech transfer are compatible