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Role of Rho-A in Glaucoma
Jasleen Kaur
Narmada Jayasankar
Vijetha Vemulapalli
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Outline
Open angle Glaucoma RhoA pathway and hypothesis CATPA
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Open Angle Glaucoma
It can be defined as damage to the Optic nerve due to Increase in Intra ocular pressure (IOP)
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Anatomy of the angle
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Trabecular meshwork
Shields textbook of glaucoma-2005
Cornea
Retina
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Cell cytoskeleton
Green: actinRed: mitochondriaBlue: nucleus
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TM Cell Contractility
Aqueous humor regulation is done by TM cell contractility and re-alignment of pores.
There are two pathways that regulate TM contractility.
Ca dependent pathways And the Ca independent pathway. Rho-a protein is involved in the Ca
independent pathway.
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General Function of Rho-A
Involved in the maintenance of tight junctions. Tight junctions are found in epithelial cells
and all cells where there is a separation or demarcation into different regions.
If the Rho-A pathway does not function properly in the eye, it causes Glaucoma.
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Ca independent pathway
GDI
GAP
GEF
GTP GDP
P
RhoA-GDP
Plasma membrane
ContractionRelaxation MLC pMLC
M20
MYPT1
PP1C
Active MLCP
M20
MYPT1
PP1C
Inactive MLCP
RhoA-GDP RhoA-GTP Rho kinase
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CATPA
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CATPA
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Point Mutations
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Point Mutations
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References 1. http://biology.kenyon.edu/BMB/Chime2/
2002/rhoA/FRAMES/captxt.htm 2. http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=165390 3. PDB, CATH, SCOP 4. http://ajpcell.physiology.org/cgi/content/full/275/3/C798 5.http: //www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1220893 6. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=14815 7. http://147.52.72.117/ijmm/2002/volume9/number6/563-570.pdf 8. http://apodaca2.dept-med.pitt.edu/PDFs/Rajasesekeran-TJs.pdf 9. www.ucl.ac.uk/ioo/research/greenwood.htm