Download - Regulation of osmolarity
REGULATION OF
OSMOLARITY
ANMOL JILANI
OSMOLARITY:
It is the measure of solute concentration, defined as the number of osmoles of solute per litre of solution.
Normal Value: 300mOsm/L
CONTROL OF ECF OSMOLARITY & SODIUM CONCENTRATION:
Regulation of ECF osmolarity & sodium concentration are closely related.
Osmolarity must be precisely controlled because they determine the distribution of fluid between intracellular and extracellular compartment.
REGULATION OF OSMOLARITY
ADH-hormone(Antidiuretic Hormone)Also called vasopressin
Thirst Mechanism
Aldosterone- hormone
Angiotensin II- peptide
OSMORECEPTOR-ADH FEEDBACK SYSTEM
ADH ACTS ON DISTAL TUBULE & COLLECTING DUCT
REGULATION OF ADH SECRETION
THIRST MECHANISM
Many of same factors that stimulate ADH secretion also increase thirst,which is defined as the concious desire for water.
THIRST MECHANISM
Dehydration
Osmolarity
Stimulus to thirst center
Water intake
ECF volume
CONTROL OF THIRST
ANGIOTENSIN II & ALDOSTERONE SYSTEM
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