Download - Presentation of Can
Centrum für Angewandte Nanotechnologie (CAN) GmbH 1
• CAN GmbH – Center for Applied Nanotechnology GmbH
• Concepts from Science to Industry
• Dr. Frank Schröder-Oeynhausen
Center for Applied Nanotechnology (CAN) GmbH 2
Nanotechnology
in Germany
Borstel:
Nanobiomedicine
Lübeck: UKSH
Lasercenter,
Nanobiomedicine
GKSS:
Membranes,
Nanomaterials TUHH:
Nanomaterials for
Transport Systems,
CNTs, Polymers, Fuel
Cell Systems
DESY:
Characterisation,
Dynamics on the
nanometer scale
EMBL:
Nanobiochemistry of
proteins
UKE, HPI:
Nanobiomedicine,
Molecular Imaging
BNI:
Nanobiomedicine
University HH:
Nanoparticle synthesis,
Nanomaterials,
Nanobiochemistry,
Energy Research,
Catalysis,
Nanostructures,
Nanoanalytics,
Nanodevices,
Theory of Nanosystems
huge
Medium
small
Activity:
CAN GmbH
Nanotechnology
in Hamburg
Center for Applied Nanotechnology (CAN) GmbH
Optically transparent
size 102
100
10-2
10-4
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10-8
1 nm 1µm 1mm 1m
Surface to volume ratio
Nanotechnology
Properties
Center for Applied Nanotechnology (CAN) GmbH
Center for Applied Nanotechnology (CAN) GmbH 5
Our main expertise is on the production and
functionalization of nanoparticulate and nanocomposite
materials, encapsulation of active ingredients as well as
development of nanoparticle-based biological and
medical markers for the cosmetics-, consumables- and
pharma industry.
We produce nanoparticles of highest quality, offers
contract research and development services in the area of
nanotechnology and participates in national and
international research programs.
Mission: We offer nanoparticles for your purpose!
5 nm
Company Profile
Mission
Center for Applied Nanotechnology (CAN) GmbH 6
Academia CAN GmbH Market
Science
Publications
Patents
Project Management
Standardization
Prototyping
Benchmarking
Products
Company Profile
General Conditions
Collaborative
Research
Own
Products
Contract
Research
Center for Applied Nanotechnology (CAN) GmbH 7
Business Model: Public Private Partnership (PPP)
Founded: November 2005
Location: Hamburg
Staff: 25 + 6 (today)
Sales: 1.318.000 € (2009)
Partners: Verein zur Förderung der Nanotechnologie e.V. (65,2 %)
Free and Hanseatic City of Hamburg (24,8 %)
University Hamburg (10 %)
Subsidiaries: Screening Port Hamburg GmbH. (80,2 %)
Head of Supervisory Board: Prof. Dr. Klaus-Peter Wittern
Chief Scientific Officer: Prof. Dr. Horst Weller
Chief Operation Officer: Dr. Frank Schröder-Oeynhausen
Company Profile
Concept
Center for Applied Nanotechnology (CAN) GmbH 8
Fields of Business Transfer Model:
• I. Cosmetics / Flavours: Contract Research
Thickener, Emulsions, Encapsulation
• II. Medicine / Medical Technology:
Nanoparticles for Diagnostics Own Products
Drug Delivery Systems International Collaboration
Analytics / Toxicity Service Tox-Tests
Analyses of Nanostructures Service Analytics
Assay Development
• III. Technical Applications:
Security Labels Contract Research (conf.)
Nanostructured Functionalized Layers National Collaboration
Business Segments
Center for Applied Nanotechnology (CAN) GmbH 9
Nanoparticles
• Synthesis of ZnO - and TiO2 - nanoparticles
• Modification of nanoparticles
Polymers
• Thickener für water- and oilbased systems
• Systems for hair-repair
• Emulsions
• Mucoadhesive polymers
Encapsulation
• Encapsulation of drugs and flavours
• Water/Oil - nanoemulsions
Contact:
Personal Care: Dr. Marcel Ruppert ([email protected])
Hair Care: Dr. Marc Thiry ([email protected])
Contract
Research
Business Segment I: Cosmetics
5 nm
Ligands define stability and chemistry:
• Biocompatibility
• Coupling mechanisms
Core defines properties
depending on size:
• Colour
• Magnetism
• Conductivity
• Thermodynamics 5 nm
Nanoparticles: Properties
Center for Applied Nanotechnology (CAN) GmbH
Business Segment II: Medicine
• Fluorescent Nanoparticles
• Emission max: 500 to 620 nm
• High reproducible properties
• Soluble in water or non-polar organic
solvents
• High physical and chemical stability
12
Business Segment II: Medicine
Features
Structure
• CdSe/CdS/ZnS dots
• Core-shell-shell structure
• Scalable core size
• Core and core-shell particles available, too
Own
Product
Center for Applied Nanotechnology (CAN) GmbH
Nanoparticles: CANdot® Series A
18 Center for Applied Nanotechnology (CAN) GmbH
• Magnetic nanoparticles
• Diameter between 5 and 30 nm
• Small size distribution
• Soluble in water or non-polar, organic
solvents
• FeOX nanoparticles
• Hydrophobic acids for organic solvents
• Hydrophilic polymers for water
• Doping possible
magnet
Own
Product
Features
Structure
Business Segment II: Medicine
Nanoparticles: CANdot® Series M
A) Vapour Deposition (PVD / CVD)
B) Sol-Gel Technique
C) Wet-Chemistry
13 Center for Applied Nanotechnology (CAN) GmbH
“Hot Injection Process”
Advantages
• universal applicable
• well known
• broad temperature range
Disadvantages
• temperature profile hard to
control
• slow mixing after injection
• “up-scaling” difficult
Nanoparticles: Synthesis
Business Segment II: Medicine
14 Center for Applied Nanotechnology (CAN) GmbH
“Flow Synthesis”
Nanoparticles: Synthesis
Business Segment II: Medicine
A) Vapour Deposition (PVD / CVD)
B) Sol-Gel Technique
C) Wet-Chemistry
15 Center for Applied Nanotechnology (CAN) GmbH
Nanoparticles: Synthesis
Business Segment II: Medicine
Nanoparticles: Properties
Center for Applied Nanotechnology (CAN) GmbH
Business Segment II: Medicine
5 nm
Service
Analytics
19 Center for Applied Nanotechnology (CAN) GmbH
Toxicity of Nanoparticles
Business Segment II: Medicine
size
shape
shells
ligands
quality
skin
lung
intestine
ICC
nanoparticle modification interaction
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Example for studying the interaction between nanoparticles and cell system
• Red: Epithelial-cells (lung), stained with Draq5 (nucleus)
• Blue: CdSe-CdS nanoparticles with different blockcopolymer-labels, located in the cell cytosol and the cell membrane
Contact:
Toxicity: Dr. Thomas Frahm ([email protected])
Toxicity of Nanoparticles
Business Segment II: Medicine
Service
Center for Applied Nanotechnology (CAN) GmbH
• The goal of VIBRANT is the development of nano-
technology-based systems for diabetes diagnosis
and/or therapy. from the pharmaceutical industry.
• CAN and UHH will provide a contrast agent
providing a stable and high signal intensity, which is
highly specific to the cell type, but low toxicity,
EU project VIBRANT
Ihr Ansprechpartner:
Dr. Theo Schotten ([email protected])
http://www.fp7-vibrant.eu/ Ultimately, VIBRANT will deliver β-
cell specific, functionally optimized
nanoconstructs and defined know-how
for in vivo applications in non-human
primates and humans with regard to
quantification of BCM, imaging of
Centrum für Angewandte Nanotechnologie GmbH
Biocompatible Shell
~ 20 - 300 nm
Quantum Dots
Superparamagnetic particle
Ligand
Anchor/Linker
Micelle or Vesicle
The Nanocontainer Specific coupling agent
• EU Framework 7 Large Scale Project
• Idea and coordination: CAN GmbH
• Duration: 7/2009 to 6/2013
• Grant: 8 Mio EUR
• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark, Sweden and Germany
• Industrial Advisory Board: big pharma.
Outline
Ihr Ansprechpartner:
Dr. Theo Schotten ([email protected])
http://www.fp7-vibrant.eu/
International
collaboration
The “Axis of Excellence”*
*) R = 0.989! ;-)
International
collaboration
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CANdots® Series X as Security Labels:
• Activation of the host lattice by doping with rare-earth elements
• Reproducible Shape of Particles (spheres to ellipsoids, synthesis specific)
• Reproducible Size of Particles (7 to 40 nm, material- and synthesis specific)
• Physical und Chemical Stability (photo stabilized, inert to high temperatures, acids, bases und
organic solvents)
Contact:
Polymers: Dr. Jan Niehaus ([email protected])
Center for Applied Nanotechnology (CAN) GmbH
Security Labels
Business Segment III: Technical Applications
Contract
Research
(conf.)
Quantum Dot-
Carbon Nanotube
Composites
B.Hernandez-Juárez, C. Klinke, A.Kornowski, H. Weller
Institute of Physical Chemistry. Universität Hamburg.
Center for Applied Nanotechnology (CAN) GmbH
New Concept of a Solar Cell
Business Segment III: Technical Applications
Center for Applied Nanotechnology (CAN) GmbH
New Concept of a Solar Cell
Business Segment III: Technical Applications
+ -
CB
VB
e
e
e
e
e
h
e
conductive polymer
h+
e-
e.g. Photovoltaics Collaboration
with Academia
Centrum für Angewandte Nanotechnologie (CAN) GmbH 28
Example: VIBRANT, EU-Project
• EU Framework 7 – NMP – Large Scale Project
Nanosciences, Nanotechnologies, Materials and New
Production Technologies
• Goal of the project: Development of marker systems for diabetes diagnostics
• Coordination: CAN GmbH
• Timeframe: 7/2009 to 6/2013
• Budget: about 8 Mio EUR
• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark,
Sweden and Germany)
• Industrial Advisory Board
• Internet: www.fp7-vibrant.eu
• Coordination of the application process (two step process)
Collaborative Research Projects
Business Model:
Intellectual Property Rights owned by CAN
1. Method for producing alkaline earth sulfate nanoparticles (Basolute I)
2. Process for preparing dispersible sulfate nanoparticles (Basolute II)
3. Luminescent core/shell nanoparticles
4. Core/shell nanoparticles suitable for (F)RET-assays
5. Synthesis of nanoparticles comprising metal(III)vanadate
6. Security printing liquid and method using nanoparticles
7. Paramagnetic nanoparticles
8. Synthesis of nanoparticles (Dotnan)
9. X-Ray opaque dental nanomaterials
10. Postsynthetic polyacid/base modification of nanoparticles
11. InP nanoparticles and method for their manufacture
12. Reactor for the synthesis of nanoparticles
13. …
Center for Applied Nanotechnology (CAN) GmbH 29
Patents, Products
Business Model:
CANdots Series A
CANdots Series X
Centrum für Angewandte Nanotechnologie (CAN) GmbH 30
First Contact
• Discussion on ideas / problems / requests
• Non Disclosure Agreement (NDA)
Concept
Agreement on:
• R&D goals
• Timeframe
• Budget
• Patent- and License issues
• Other partners
• Legal issues
Contracts
• Small jobs (< 10 T€)
• Feasibility Studies (< 50 T€)
• R&D Contracts (> 50 T€)
Contract Research
Business Model:
Consulting and Service
• Studies
• Surveys
CAN-Analytics
• Scanning Electron Microscopy (SEM / TEM)
• Static and Dynamic Light Scattering (SLS / DLS)
• X-Rax Scattering (SAXS / WAXS)
• Atomic Force Microscopy (AFM)
• Infrared Spectroscopy
• Mass-Spectrometry (MS, MALDI-MS)
• Absorption Spectroscopy (UV-Vis, NIR)
• Fluorescence Optical Microscopy
• Confocal Laser-Scanning Microscopy
• Electron Spin Resonance-Spectroscopy
• SQUID Magnetometry
• Chromatography
• Rheology
Center for Applied Nanotechnology (CAN) GmbH 31
Service
Business Model:
University of Hamburg
Cooperation Contracts
Companies:
Beiersdorf AG www.beiersdorf.com
Eppendorf AG www.eppendorf.com
BODE Chemie GmbH www.bode-chemie.de
Merck KGaA www.merck.de
Bayer AG www.bayer.de
Institutions:
Free and Hansestadt Hamburg http://fhh.hamburg.de/
Hamburger Sparkasse www.haspa.de
Hamburg Chamber of Commerce www.hk24.de
Innovationsstiftung Hamburg www.innovationsstiftung.de
Life Science Agentur Norgenta www.norgenta.de
Center of Competence Hansenanotec www.nanoscience.de/hansenanotec/
Center for Applied Nanotechnology (CAN) GmbH 32
Partner
CAN GmbH:
Center for Applied Nanotechnology (CAN) GmbH 33
www.can-hamburg.de
Center for Applied Nanotechnology (CAN) GmbH
Grindelallee 117
20146 Hamburg
Germany
T +49 40 42838 – 4983
F +49 40 42838 – 5797
… get in contact !
CAN GmbH: