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Edited for the Society by Eva King Killam
VOLUME 256. NUMBER 2. FEBRUARY 1991
JPETAB 256 (2) 421-819 (1991)
The Journal of
PHAR IACOLOCYAND EXPERIMENTAL THERAPEUTICS
A Publication of The American Society
for Pharmacology and Experimental TherapeuticsFounded by John J. Abel -1909
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The Journalof
PHARMACOLOGYAND EXPERIMENTAL THERAPEUTICS
A Publication of The American Society
for Pharmacology and Experimental Therapeutics
Founded by John J. Abel 1909EDITOR
Eva King Killam
ASSISTANT EDITOR
Mannfred A. Hollinger
EDITORS FOR SPECIFIC FIELDS
Analgesia and Drug Abuse
william L. DeweyBilly Martin
Autonomic Pharmacology
Robert R. Ruffolo, Jr.Robert E. Stitzel
Behavioral Pharmacology
John A. Harvey
Cardiovascular Pharmacology
Leslie E. BaileyHenry R. Besch, Jr.Theodore M. BrodySue Piper Duckles
Endocrine Pharmacology
Paula H. Stem
Gastrointestinal Pharmacology
Timothy S. GaginellaChemotherapy Frank Porreca
H. George Mandel Immunopharmacology
Developmental Pharmacology Sydney SpectorBemard L Mirkin Neuropharmacology
Drug Metabolism and Disposition Edmund G. AndersonEdward BresnickJordan L Holtzman
David B. BylundS. J. EnnaCharles 0. Rutledge
Prostaglandins and Leukotrienes
Guy C. Le BretonK. U. Malik
Pulmonary Pharmacology
Mannfred A. Hoilinger
Renal Pharmacology
William 0. Bemdt
Toxicology
Curtis D. Klaassen
EDITORIAL ADVISORY BOARD
Margaret AcaraMartin W. AdlerEdson X. AlbuquerqueJulius C. AllenJames B. AppelLewis AronowWilliam D. AtchisonAlbert J. AzzaroRobert L. BalsterPaul BassMichael A. BeavenDonald M. BersJohn A. BevanC. Paul BianchiDavid A. BlakeAlan S. BloomFloyd E. BloomPeter G. BradfordCarl K. BucknerTheodore J. CiceroMarlene L. CohenCharles R. CraigLuigi X. CubedduE. E. DanielWilliam C. de GroatLouis DiamondGerald F. DiBonaRobert J. DinersteinWalter R. DixonJ. W. Downie
Linda DykstraHugh L. EvansJerry M. FarleyHarold FeinbergGregory 0. FinkStephen K. FisherGarret A. FitzGeraldRay W. FullerGerard L. GebberJames W. GibbC. Norman GillisShn N. GinThomas P. GreenGarrett J. GrossR. Adron HamsRichard J. HeadJ. Paul HiebleStephen G. HoltzmanJerry B. HookE. H. JefferyRobert M. JoyGeorge J. KaloyanidesAlexander G. KarczmarTerry KenakinConan KometskyEdwin A. KroegerDavid D. KuSuzanne G. LaychockTonyJ.-F. Lee
Roberto LeviGeorge E. LindenmayerHorace H. LohBenedict R. LucchesiThomas A. McCaldenRobert B. McCallDonald E. McMillanW. H. MorseHasan MukhtarKevin MullaneL. Charles MumnJose M. MusacchioAllen H. NeimsJon A. NormanRobert F. O’DeaAchilles J. PappanoLeslie V. PariseGavril W. PastemakWilliam A. PettingerLarissa A. PohoreckyGarth PowisDonald V. PnolaRussell A. ProughDavid RaebumArthur RainesArnold SchwartzLewis S. SeidenPaul J. SilverDavid J. Smith
Roger P. SmithRoger 0. SpealmanJanice L. StickneyJohn L. SutkoBoris TabakoffA. E. TakemoriDavid A. TaylorRobert E. Ten EickThomas R. TephlyRichard E. TesselMartin J. M. C. ThoolenPieter B. M. W. M. TimmermansMyron L. ToewsTheodore J. TorphyU. TrendelenburgNorman J. UretskyPaul M. VanhoutteRalph VinegarLarry A. WalkerMartin A. WassermanR. Clinton WebbI. M. WeinerRichard M. WelchGrant R. WilkinsonMichael WilliamsMartin M. WinburyRaymond J. WinquistBarry B. WolfeHenry I. Yamamura
BOARD OF PUBLICATIONS TRUSTEES
Joel G. Hardman, Chairman: Arthur J. Atkinson, Jr., Marlene L. Cohen, T. Kendall Harden, Eva King Killam,Horace Loh, Kenneth E. Moore, Marcus M. Reidenberg, Robert E. Stitzel, Vincent G. Zannoni
EXECUTIVE OFFICER OF ThE SOCIETY
Kay A. Croker
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (ISSN 0022-3565) is an official publication of The AmericanSociety for Pharmacology and Experimental Therapeutics and is published monthly by Williams & Wilkins, 428 E. Preston Street, Baltimore, MD 21202.3993. Second class postage paid at Baltimore, MD and at additional mailing offices. POSTMASTER: Send address changes to THE JOURNAL OFPHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 428 E. Preston St., Baltimore, MD 21202.3993. Indexed by Current Contents,Index Medicus and BioSciences Information Service. Subscription rates $170.00 ($235.00 foreign), institutions $285.00 ($350 foreign), single copy $18.00($22.00 foreign). Prices are subject to change. Copyright © 1991 by The American Society for Pharmacology and Experimental Therapeutics.
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AUTHOR INDEX
Apparsundaram, S., 486
Areso, P., 656Baldi, E., 581Beckmann, M. L., 542
Behrens, N. D., 462Beniston, D., 650Bennett, E. L., 650
Boarder, M. R., 628Boeckxstaens, G. E., 441Bogers, J. J., 441
Bousquet, P., 606Braff, D. L., 530
Brann, M. R., 727
Brown, T. J., 480Bult, H., 441
Burks, T. F., 547Bushnell, P. J., 741Cannon, J. G., 751
Chang, A. S.�S., 734
Chen, C.-J., 486
Christ, G. J., 553Cipkus.Dubray, L. A., 492
Cohen, M. L., 695Cohen, R. B., 639Colatsky, T. J., 639
Conway, P. G., 621
Cooke, J. P., 704
Daniel, E. E., 670
De Man, J. G., 441Done, F., 727
Duckles, S. P., 513, 519
Dunn, M. J., 581El.Fakahany, E. E., 468Farmer, S. C., 547
Feldman, J., 606
Flynn, J. R., 751
F#{246}rstermann, U., 677
Frazer, A., 656
Fr#{246}lich,J. C., 677
Frnka, J. V., 734
Fujimoto, J. M., 448
Fujiwara, M., 683
Gambarana, C., 656Gerber, J. G., 542
Gessner, G., 614Geyer, M. A., 530
Gonon, F., 606Granneman, J. G., 421
Hamahashi, T., 634
Han, B.-J., 704Hartman, H. B., 621
Hasegawa, H., 773
Hauser, J., 592Havens, C. N., 639Heikkila, R. E., 506
Heim, K. F., 537Hensler, J. G., 656Herman, A. G., 441
Hieble, J. P., 599Hofman, G. A., 665
Horn, D. S., 710
H#{246}nack,D., 432
Homer, E., 614Hubbard, J. W., 621
Hupe, D. J., 462Ichiyama, A., 773
Ishikawa, K., 650Itoh, T., 634
Janssen, L. J., 670Jean-Jacques, M., 553Johnston, P. A., 587Kachur, J. F., 562Kamatchi, G. L., 426
Kamisaki, Y., 634Kaneko, E., 773Kau, S. T., 587
Keith, V. A., 530
Khan, S. A., 492Kimura, T., 525
Knight, D. L., 787, 795
Kobayashi, T., 773
Kosley, R. W., Jr., 621Koster, A. Sj., 665Kuhn, M., 677Kurahashi, K., 683
Lai,J.,689Lam, D. M.-K., 734
Lambrecht, G., 727Lappi, S. E., 757
Law, P. Y., 710
Lebedinsky, Y., 621
Lee, F., 704
Lee, N. H., 468
Legrand, C., 767Leonard, P. A., 751
Lichtenstein, L. M., 717Lin, M., 645Lodge, N. J., 639Loh, H. H., 710Lokhandwala, M. F., 486Long, J. P., 751Lookingland, K. J., 500
Loscaizo, J., 704L#{246}scher,W., 432
Lucaites, V. L., 695Lutfy, K., 575
Ma, S., 751Major, T. C., 568Maltier, J..P., 767Manzanares, J., 500
Martinez, J. L., Jr., 650
Mason, N. R., 695Massamiri, T., 519
McGonigle, P., 811Mei, L., 689
Meijer, D. K. F., 458Meisheri, K. D., 492
Mendelsohn, L. G., 695Mermet, C., 606Mita, C., 634Moore, K. E., 500Mukaiyama, 0., 525
Mulder, G. J., 458Mutschler, E., 727
Nelson, T. E., 645
Nemeroff, C. B., 787, 795
Nies, A. S., 542Noordhoek, J., 665
Nordstrom, L. C., 621Noronha-Blob, L., 562
Nudelman, K. A., 650
Oleynek, J. J., 492
Olszyk, V. B., 741
O’Malley, G. J., 621
Oosterbosch, L., 441
Ordway, G. A., 656
Otten, A., 677
Owens, M. J., 787, 795
Padilla, S. S., 741
Panek, R. L., 568
Peachell, P. T., 717
Pelckmans, P. A., 441
Pendleton, R. G., 614
Peters, K., 462
Pfefferkorn, E. R., 462
Polhuijs, M., 458
Pope, C. N., 741
Porreca, F., 547Pracyk, J. B., 757Purohit, S. 5., 492
Rady,J.J.,448Raeburn, D., 480
Ramwell, P. W., 537
Rapundalo, S. T., 568Redegeld, F. A. M., 665
Rigolot, C., 767
Riordan, D. E., 506Ritchie, J. C., 787, 795Rivi#{232}re,P. J. M., 547
Roerig, S. C., 448Roeske, W. R., 689
Rosenzweig, M. R., 650Satoh, S., 525
Sauermelch, C. F., 599Schelm, J. A., 780Schleimer, R. P., 717Schulteis, G., 650Shaffer, J. E., 704Shibanoki, S., 650
Shimaji, H., 683Shirahase, H., 683
Simmerman, J., 568
Simpson, P. J., 780
Slotkin, T. A., 757
Smith, G. F., 780
Sonsalla, P. K., 506
Subramaniam, S., 811
Swerdlow, N. R., 530
Swirtz, M. A., 492
Szabo, S., 592
Tacke, R., 727
Takeuchi, A., 525
Taylor, D. G., Jr., 568Thomas, G., 537
Thomson, S., 704
Tibiri#{231}a,E., 606
Ticku, M. K., 426
Usui, H., 683van de Leo, P. G. F., 665
Van Maercke, Y. M., 441Vivat, V., 767
Volpe, P., 645Ward, T., 741
Weinberger, S. B., 650Weishaar, R. E., 568
Wess, J., 727Whitty, C. J., 421
Wilkes, L. C., 628Willette, R. N., 599Wilson, S. K., 801Yamamura, H. I., 689Yoburn, B. C., 575
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