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PATHOLOGY of ENDOCRINE, SKELETAL SYSTEM
and SKIN (Diabetes mellitus – kidney, Goiter, Feochromocytoma, Carcinoid.
Osteomyelitis, Osteodystrophy.
Dermatomyositis, Verruca vulgaris, Molluscum contagiosum, Atheroma,
Basal cell papilloma)
General medicine
Prof. MUDr. Pavel Babál, CSc.
Department of Pathology FM CU
Sasinkova 4, Bratislava
Prof. MUDr. Ľudovít Danihel, CSc.
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PATHOLOGY of ENDOCRINE SYSTEM
Diabetes mellitus (159)
= chronic disease with permanent hyperglycemia in relative
or absolute absence of insuline
1.) Type I DM (total insuline deficiency)
2.) Type II DM (relative insuline deficiency)
3.) Other types of DM
4.) Gestational DM
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Intercapillary glomerulosclerosis and artheriolosclerosis
calcifiication
artheriolosclerosis
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Interkapilárna glomeruloskleróza a artérioloskleróza Intercapillary glomerulosclerosis and artheriolosclerosis
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Interkapilárna glomeruloskleróza a artérioloskleróza Intercapillary glomerulosclerosis and artheriolosclerosis
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Intercapillary glomerulosclerosis leading to glomerular fibrosis
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PATHOLOGY of ENDOCRINE SYSTEM
GOITER (STRUMA) (69, 70, 240)
• Hashimoto disease (thyroiditis)
• Graves disease (Basedow struma,
autoimmune hyperthyreodism)
• Nontoxic goiter - diffuse
- nodular
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Hashimoto disease
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Hashimoto disease
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Hashimoto disease
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Graves disease
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Graves disease
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Nodular goiter
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Nodular goiter
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PATHOLOGY of ENDOCRINE SYSTEM
Feochromocytoma (193)
• more frequent in adults
chromaffinity of cytoplasm (catecholamines)
• in children prevalence of neuroblastoma (sympatoblastoma)
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Feochromocytoma
Kôra nadobličky
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Feochromocytoma
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PATHOLOGY of ENDOCRINE SYSTEM
Neuroendocrine tumor (carcinoid) (184)
• large intestine, small intestine, bronchi, pancreas, other...
• (serotonin, callicrein... „carcinoid syndrome“)
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Carcinoid in large intestine
mucosa
C A R C I N O I D
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Carcinoid in large intestine
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Carcinoid in large intestine
CARCINOID
mucosal gland
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PATHOLOGY of SKELETAL SYSTEM
Osteomyelitis (139)
= infectious bone inflammation
• nonspecific (purulent)
• specific, granulomatous (Tbc, syphylis, sarcoidosis; brucellosis, typhoid)
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Osteomyelitis
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Osteomyelitis
leukocytes
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PATHOLOGY of SKELETAL SYSTEM
Osteodystrophy (156)
(ostitis deformans Paget)
(paramyxovirus)
- osteoclasts (large), later osteoblasts ... chaotic remodelling of bone tissue
- resorptive lacunae, osteoid, irregularly thickened compact bone,
fibrous bone marrow
- complication – osteosarcoma (IL6)
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Paget disease
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Paget disease
Bone
trabecule
Fibrosis
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Paget disease
BT
F
BT
F
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PATHOLOGY of SKELEAL SYSTEM
Dermatomyositis (polymyositis) (226)
• autoimmune disease (Ag ... capillary endothelium ?)
• in the skin - perivascular and periadnexal lymphocytic infiltrates
• lymphocyte-plasmocytic infiltrate, degenerative changes of muscle
fibres, fibrosis (scarring)
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Dermatomyositis
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Dermatomyositis
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SKIN PATHOLOGY
Viral infections
• Verruca vulgaris (HPV 2,4,7) (197)
• Molluscum contagiosum (poxvirus) (142)
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Verruca vulgaris
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Verruca vulgaris
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Molluscum contagiosum
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SKIN PATHOLOGY
Psoriasis (318)
• hyperkeratosis with scales
• PMN pseudoabscesses
in stratum corneum
• papilomatosis
• acanthosis
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Psoriasis
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SKIN PATHOLOGY
Atheroma (200)
• epidermal cyst from skin adnexal epithelium
• hair follicle cyst, from sebaceous gland
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Atheroma
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Atheroma
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SKIN PATHOLOGY
Basal cell papiloma (178)
• benign tumor
• senile verruca, seborrheic keratosis
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Senile verruca
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Senile verruca
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Senile verruca