Download - Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress
![Page 1: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/1.jpg)
Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
![Page 2: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/2.jpg)
Integrated Biomedical Research Program
3 Medical Schools
1 Vet-Med College
10 Institutes/Centers
51 Faculty (17 Primary)
![Page 3: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/3.jpg)
Virginia Tech
• Established in 1872• Ranked 25th for College of Engineering• Ranked 12th in Patents• Ranked 8th in Licenses to Start-ups• Best multi-scale CT facility
3
![Page 4: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/4.jpg)
Wake Forest University
• Medical School Established in 1902• Ranked 30th among National Universities • Ranked 32th in NIH Funding• Ranked 1st in Regenerative Medicine (WFIRM)
4
![Page 5: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/5.jpg)
Biomedical Imaging
Nuclear Imaging CT/X-Ray MRIBioluminescence &
Fluorescence
![Page 6: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/6.jpg)
Computed
Tomography
Bioluminescence
Imaging
Optical
Tomography
Bioluminescent
Views
Individualized
Volume
Shape
Model
Optical
Model
3D
Mapping
Wang G, et al.: In vivo mouse studies with bioluminescence tomography. Optics Express
14:7801-7809, 2006
Bioluminescence Tomography (2002)
![Page 7: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/7.jpg)
Recently Awarded BRP (“973”)
![Page 8: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/8.jpg)
Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
![Page 9: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/9.jpg)
Scanning for Faster Speed
Spiral into Modern CT Era
Ray Sum
![Page 10: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/10.jpg)
Spiral Fan-beam CT (1983)
![Page 11: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/11.jpg)
Ray A
1D Detector Array
x
y
zz
Interpolation to Planar Data
![Page 12: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/12.jpg)
![Page 13: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/13.jpg)
Spiral Cone-beam CT (1991)
Wang, G, Lin, TH, Cheng PC, Shinozaki DM, Kim, HG: Scanning cone-beam reconstruction algorithms for x-ray microtomography. Proc. SPIE Vol.
1556, p. 99-112, July 1991 (Scanning Microscopy Instrumentation, Gordon S. Kino; Ed.)
![Page 14: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/14.jpg)
Multiple Implications
To solve the long-object problem, a first level of improvement with respect to the 2D FBP
algorithms was obtained by backprojecting the data in 3D, along the actual measurement rays.
The prototype of this approach is the algorithm of Wang et al.
Defrise, Noo, Kudo: A solution to the long-object problem in helical cone-beam tomography. Phys. Med. Biol. 45:623-643, 2000
Many advances in CB reconstruction have been made recently thanks to the quest for an
attractive reconstruction method in helical CB tomography.
Pack, Noo, Clackdoyle: Cone-beam reconstruction using the backprojection of locally filtered projections. IEEE Trans. Medical Imaging 24:1-16, 2005
![Page 15: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/15.jpg)
Seeking Exact Solution (1997)
“Cone-beam spiral CT seems an ideal imaging mode. It is desirable and possible that
an exact cone-beam reconstruction algorithm be designed that takes longitudinally
truncated cone-beam data and is computationally efficient.”
Wang G, Cheng PC, Vannier MW: Spiral CT - Current status and future directions. Proc. SPIE 3149 203–12, 1997
![Page 16: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/16.jpg)
Katsevich Formula (2002)
dsdxsqyDqsyx
xf sqf
xIPI
sin
1|)),,(),((
|)(|
1
2
1)(
2
0)(
),(),(),( xsuxsxse ),(sin),(cos),,( xsexsxs
)( 0sy
e
),( xsu
),( 0 xs
)( 1sy
)( 2sy
)(xf
Detector
Plate
Source
Object
Pi-Line
Katsevich A: A general scheme for constructing inversion algorithms for cone beam CT. Int'l J. of Math. and Math. Sci. 21:1305-1321, 2003
![Page 17: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/17.jpg)
h-index=30
Annually, ~100M CT scans are performed in USA alone
![Page 18: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/18.jpg)
Dual-source CT (2003)
Dual-source In vivo Micro-CT scanner
Designed by BIR, Hoffman, Wang
Built by BIR in 2003
Bioluminescence tomography prototype
Designed by Wang, Hoffman, McLennan
Built by us & UI Med. Inst. Facility in 2003
![Page 19: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/19.jpg)
Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
![Page 20: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/20.jpg)
Interior Tomography (2007)
![Page 21: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/21.jpg)
Sparsity-based Interior Recon
![Page 22: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/22.jpg)
Inner Vision with Local Data
t
Sinogram
X-rays
Proje
ctio
n:
Linea
r inte
grals
ty
x
Measurement
Reconstruction
Object
),( yxf
),( tP
X X
![Page 23: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/23.jpg)
Ultrafast Temporal Resolution
![Page 24: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/24.jpg)
From Scanning to Roaming
![Page 25: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/25.jpg)
Extension to Other Modalities
Ge Wang, Hengyong Yu
![Page 26: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/26.jpg)
Limited Angle Interior Tomography
![Page 27: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/27.jpg)
Interior CT Patent
![Page 28: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/28.jpg)
Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
![Page 29: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/29.jpg)
SBES Advanced Multi-scale CT Facility
![Page 30: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/30.jpg)
Nano-CT Momentum
Andrew G. Peele et al.: High Resolution X-ray phase tomography. Proc. SPIE CT Conference, 2010
![Page 31: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/31.jpg)
Interior Nano-CT
X-ray Beam Central Stop
Condense Lens
Sample
Zone
Plate
Phase Ring
Detector Plane
ROI
Sample Stage
![Page 32: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/32.jpg)
Potential for Study on Earliest Life
Hagadorn JW, et al. (2006) Cellular and subcellular structure of Neoproterozoic embryos.
Science 314:291–294
![Page 33: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/33.jpg)
Smaller Scales?
![Page 35: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/35.jpg)
Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
![Page 36: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/36.jpg)
Multi-parameter CT
![Page 37: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/37.jpg)
Wang G, Cong W, Shen H, Zou Y: Varying Collimation for Dark-Field Extraction. International Journal of
Biomedical Imaging. 2009, Article ID 847537, 2010
Dark-field Tomography
![Page 38: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/38.jpg)
Multi-energy CT
![Page 39: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/39.jpg)
![Page 40: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/40.jpg)
![Page 41: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/41.jpg)
Acknowledgement
Important collaborators include, but not limited to, Drs. E. W. Bai, J. A. Brink, Z. Q. Chen, P. C. Cheng, W. X. Cong, M. Furth, W. M. Han, M. Jiang, A. Katsevich, Y. Li, L. Li, H. O. Shen, D. M. Shinozaki, D. L. Snyder, S. Soker, M. W. Vannier, S. Wang, Y. B. Wen, C. Wyatt, Y. Xu, J. S. Yang, Y. B. Ye, H. Y. Yu, J. Zhao, T. G. Zhuang, and Y Zou.
This work is partially supported by multiple NSF, NIH and industrial grants.
![Page 42: Outline Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress](https://reader035.vdocuments.mx/reader035/viewer/2022062407/56649d2e5503460f94a05802/html5/thumbnails/42.jpg)
Thank You for Invitation!