Download - nuclear envelope
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Nuclear receptorsNuclear receptors
Emilie Lilford
Group 11
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Biochemical definition of a receptor
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Chemical change physiological change biological function
LigandLigand
ReceptorReceptor
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Types of receptors and locations:• Cell surface receptors • Receptors located in the cytoplasm• Nuclear receptors Nuclear receptors
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Ligands of nuclear receptors
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Structures of some nuclear receptor ligands and their corresponding receptors name.
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Structural organization
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Sandwich filling model of ligand binding domain (LBDLBD)
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DNA binding domain (DBDDBD) – structure of the human progesterone receptor
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What is a Domain?
• Independent subunits of proteins.• Between 25 -500 amino acids in length. • Independently stable and folded.• Can diverge and converge.• Domain represents function. Domain represents function.
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Domains of nuclear receptors
• Zinc fingers• LBD• DBD • N-terminal + C-terminal
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How nuclear receptors work.
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