Download - Needle free injections rohit bharti
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Department Of Pharmaceutics
Presented By : Guided By :
Mr. Rohit U. Bharti Prof. R. S. Pentewar [HOD]
ChannaBasweshwar Pharmacy College, Kava Road, Latur-413512.1
07/02/2014
Needle free Injection :
Designed for Confidence
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PRESENTATION OVERVIEW
Introduction to Needle free injection
State of the art technology
Performance overview and past research
Current applications
Products Available in Market
Recent Technology and ongoing research
References
Questions
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WHAT IS IT ?
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Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle.
Needle-free injection techniques can be used to administer vaccinesand medications in the pork industry.
They are promoted as a possible option for patients with needle phobia
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COMPONENTS
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Giving a Needle- free Injection[1]
Fill syringe with injectate
Insert syringe into Biojector
Hold at 90º with firm pressure at injection site
Pull actuator, count to three, maintain pressure
Remove device and hold pressure at site
( patient or parent can hold )
Entire process is fast and easy
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* Sources: GAO, CDC, OSHA, University of Virginia
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Figure 4: Types of Parenteral Route 8
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Dispersion Patterns: IM Injection
Spherical bolus
lowest possible
SA/V ratio limited tissue
disruption
Amplified dispersion
medication
forced at high speed through a tiny orifice
very high SA/V ratio
enhanced tissue disruption
Injection event lasts less than 0.5 sec.
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BENEFITS OF NEEDLE-FREE INJECTIONS[2]
Eliminates needle phobia
Increased patient compliance
Higher dispersion pattern
Lower pain & stress
Targeted immune response (eg. Vaccine)
Faster injection time (0.5 sec.)
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APPLICATIONS
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1. Intramuscular, subcutaneous and intradermal administration of Vaccinese.g. smallpox, polio, measles
2. Intradermal administration of hormonese.g. growth hormone
3. Intradermal administration of anestheticse.g. Lidocaine
4. Subcutaneous administration of insulin.
5. Used in the treatment of migraine e.g. sumatriptan
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It uses pressure from a
spring loaded piston to
create a fine stream of
insulin through a small
bore nozzle, delivering
insulin to the subcutaneous
layer.
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Recojet is India’s first needle-free insulin delivery device.
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DIFFERENT NEEDLE FREE INJECTORS
AVAILABLE IN THE MARKET
Technology/product name Company name Description
Implaject Caretek Medical
Simple, hand-held needle
free injection device. Can be
configured to be reusable
with disposable cartridges.[3]
Injex 30 Injex (HNS International)
Spring-powered hand-held
device with disposable
ampoules that delivers
0.05-1 ml. Focused on
insulin delivery.[5]
Intraject Weston Medical
Applicable to drugs including
proteins, peptides,
monoclonal antibodies, small
molecules and vaccines.[6]
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CURRENT TECHNOLOGIES
B-2000 Iject
Vitajet 3
Biojector-2000
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ONGOING CLINICAL RESEARCH
Currently, over 30 research collaborations
Pharmaceutical – Biotech – Academic Centers – Government
NIH
– HIV
NCI
– lymphoma
MSK
– melanoma
USNMRC
– malaria
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THE FUTURE
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Many of these needle-free alternative technologies are in the development stage.
Inhalers are being improved as are nasal sprays, forced air injectors and patches.
In the future, other foods may be genetically enhanced to deliver vaccines and other drugs.
These include foods like bananas and tomatoes.
ID PEN™
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REFRENCES
1. Vivek Ranjan Sinha, Aman Trehan, Pramil Tiwari:”Needle Free Injection Technology”:Express Healthcare Management (1st-15th July 2005)
2. Henry, C. "Special Delivery." Chemical & Engineering News (September 18, 2000): 49-65.
3. Potera, C. "Making Needles Needless." Technology Review (September/October 1998): 67-70.
4. Potera, C. "No-Needle Vaccine Techniques." Genetic Engineering News (August 1998): 19.
5. http://bobbydyer.com/wp-content/uploads/2011/01/Needleless%20injection%20thesis.pdf
6. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nature Reviews Drug Discovery. July 2006; 5: 543-548.
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