Amblyomma americanum(Lone Star Tick)
• RMSF (Ricketsia ricketsii)• Tularemia (Francisella tularensis)
Ixodes ticksNE & Mid-West: I. scapularis
Western U.S.: I. pacificusEurope: I. ricinus
• Lyme disease (Borrelia burgdoferi)• RMSF (R. rickettsii)- mouthpart visible from dorsum- no white markings on dorsal plate
Dermacentor variabilis(American dog tick)
• RMSF• Tularemia- mouthpart visible from dorsum (short & rounded)- white markings on dorsal plate
Pediculus humanus var. corporis(Body louse)
• Epidemic typhus (Rickettsia prowazekii)• Trench fever (Bartonella quintana)• Relapsing fever (Borrelia recurrentis)
Lutzomyia(Sandfly)
• Leishmaniasis (L. mexicana, L. braziliensis)• Oroya Fever / Carrion’s Disease (Bartonella bacilliformis)• Verruga peruana (Bartonella bacilliformis)
Lycosidae(Wolf spider)
• Spider bite that releases histamine edema, erythema, necrotic eschar,
lymphangitis
Lactrodectus mactans(Black widow spider)
• Spider bite: α-latrotoxin massive Ach & NE release from presynaptic
motor endplate muscle fiber fatigue
a. Lamina lucida
b. Hemidesmosome
c. Basal keratinocyte
d. Anchoring plaques
e. Anchoring fibrils
f. Anchoring filaments
g. Keratin intermediate filaments
h. Plasma membrane
i. Lamina densa
j. Sublamina densa region
• IgG in intercellular space
ANSWER: Pemphigus vulgaris
• Desmoglein 3 (130 kd)
• Desmoglein 1 (160 kd)
A: IgG & C3 at BMZ
B: salt-split skin
C: IIF on human salt-split skin
ANSWER: Bullous Pemphigoid
• BP Ag1 (230 kd) - intracellular
• BP Ag2 (180 kd) – extracellular
•C3 > IgG favors pemphigoid over LE
A: C3 along BMZ
B: “ “ on salt-split skin
ANSWER: EBA
• Can also have IgG
• If IgG > C3, favors lupus and EBA over pemphigoid dz’s
A: Linear deposition of C3 along BMZ
B: C3 in granular pattern along BMZ
C: IgG in homogenous and shaggy pattern along BMZ
ANSWER: lupus erythematosus
NUCLEOLAR
• Photonegative of speckled pattern because it stains nucleolar RNA
• Progressive systemic sclerosis
ANTI-CENTROMERE
• Ab's to kinetochore / mitochondria on centromere
• Raynaud’s, local scleroderma (CREST-specific), PSS