Download - MEK Inhibitors From Selleck Chemicals
Specific Inhibitors of MEK/MAPK Pathway
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Solutions to Signal Transduction Research
Dear Customer,
Based on your research area, Selleck has special recommendations for you on our inhibitors ofthe MEK/MAPK pathway.
Cat. No. Inhibitor Name Purity
S1531 BIX 02189 >99%
Bioactivity: BIX 02189 is a selective MEK5/MAPK5 inhibitor with an IC50 of59 nM.
S1561 BMS 777607 >99%
Bioactivity: BMS 777607 is a Small-Molecule Met Kinase Inhibitor with anIC50 of < 0.1 μM.
S1008 AZD6244 (Selumetinib) >99%
Bioactivity: AZD6244, also known as Selumetinib, ARRY142886 and AZD-6244, is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
Applications & Feedbacks
BIX 02189 AZD6244 (Selumetinib)More Feedbacks
Papers Using Selleck Inhibitors
1. Nazarian, R., et al. Melanomas acquire resistance to B-RAF(V600E)inhibition by RTK or N-RAS upregulation. Nature. 2010 Dec 16; 468(7326):973-7.
2. Aziz, S.A., et al. Vertical targeting of the phosphatidylinositol-3 kinasepathway as a strategy for treating melanoma. Clin Cancer Res. 2010 Dec 15;16(24): 6029-39.
More Inhibitors of theMEK/MAPK Pathway
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AS703026CI-1040(PD184352)
PD0325901PLX-4032(RG7204)
by Target
MEK p38 MAPK
B-Raf JNK
Ras
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