![Page 1: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/1.jpg)
Copyright Ron Eslinger 2006
Medications Used for Sedation Medications Used for Sedation byby
NonNon--Anesthetist RNs: Anesthetist RNs:
Ron Eslinger, RN, CRNA, APN, MA
![Page 2: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/2.jpg)
Copyright Ron Eslinger 2006
Benzodiazepines
– Most widely used drug for Sedation– Probably work in limbic system and amygdala of
the brain, where fear, anxiety and apprehension arise.
– When Benzodiazepines come to these receptors from the blood stream, they go into the receptor sites and cause specific effects:
Agents Used For Moderate SedationAgents Used For Moderate Sedation
![Page 3: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/3.jpg)
Copyright Ron Eslinger 2006
BenzodiazepinesBenzodiazepines
EffectsEffects
anxiolysis ... reduction of anxietyamnesiac ... makes patient have antero-grade amnesia (not retrograde)anti-convulsive ... stops seizuresskeletal muscle relaxationsedative - hypnotic in large doses patients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine overdose these H-2 blocking drugs may dramatically increase the sedative of even small doses of Benzodiazepine.
![Page 4: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/4.jpg)
Copyright Ron Eslinger 2006
BENZODIAZEDPINESBENZODIAZEDPINES
Sedative hypnotic
No analgesic properties
Useful for seizures
![Page 5: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/5.jpg)
Copyright Ron Eslinger 2006
BENZODIAZEPINES(2)BENZODIAZEPINES(2)
Little respiratory or cardiovascular depression when used alone, but synergistic effects seen when combined with other CNS depressants
Avoid use in pregnancy, alcohol intoxication, glaucoma, other CNS depressants
![Page 6: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/6.jpg)
Copyright Ron Eslinger 2006
MIDAZOLAM (VERSED)MIDAZOLAM (VERSED)
Most commonly used sedative used for conscious sedation
3-5 times more potent than diazepam
Rarely precipitates or causes pain on injection (as valium will)
![Page 7: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/7.jpg)
Copyright Ron Eslinger 2006
Midazolam (2)Midazolam (2)
Titrate to effect in 0.5 mg increments
2-6 hours30 minutes< 10 minutesOral2-6 hours15-60 minutes5-15 minutesIM
15min. – 6hours3-5 minutes1 minuteIV
Duration of Action
Peak EffectOnset of ActionRoute
![Page 8: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/8.jpg)
Copyright Ron Eslinger 2006
Diazepam (Valium)Diazepam (Valium)
Used less than Midazolam
Titrate in 2.5mg increments
Incompatible with other agents, easily precipitates
![Page 9: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/9.jpg)
Copyright Ron Eslinger 2006
Diazepam (2)Diazepam (2)
Painful on injection
Peak effect in less than 10 minutes
Long half-life due to metabolites
3-6 hours60 minutes15-60 minutesOral15-60 minutes3-5 minutes1-5 minutesIV
Duration of Action
Peak EffectOnset of ActionRoute
![Page 10: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/10.jpg)
Copyright Ron Eslinger 2006
Reversal for BenzodiazepinesReversal for Benzodiazepines
Flumazenil (Romazicon) (Specific Benzodiazepine antagonist)
Initial Dose: 0.2 mg
Administration Technique:
– Phase One: Initially 0.2 mg IV over 15 seconds. If patient does not reach desired level of consciousness after 45 seconds.
– Phase Two: Repeat dose at one minute intervals until a cumulative dose of 1mg has been administered (this includes initial dose in phase one).
![Page 11: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/11.jpg)
Copyright Ron Eslinger 2006
Reversal for BenzodiazepinesReversal for Benzodiazepines
Peak effect:
– 6 to 10 minutes – 80% of the maximum response is seen within 3
minutes. – Anesthesia should be involved if there is no
desired clinical response with the administration of the initial 1 mg dose.
![Page 12: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/12.jpg)
Copyright Ron Eslinger 2006
Reversal for BenzodiazepinesReversal for Benzodiazepines
Potential Adverse Reactions:– nausea, vomiting, sweating, hot flashes, agitation,
headache, injection site pain– do not use Flumazenil in patients who chronically take
Benzodiazepines. May precipitate:– tremors– profuse sweating– hypotension– seizure activity
![Page 13: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/13.jpg)
Copyright Ron Eslinger 2006
Flumazenil (Romazicon)Flumazenil (Romazicon)
Indications: reversal of benzodiazepines’effects - sedation, respiratory depression, amnesia
Dose: 0.2 mg IV initially, titrate to effect
Caution in patients with seizure disorders - may reverse effects of anti-seizure medications
![Page 14: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/14.jpg)
Copyright Ron Eslinger 2006
45-90 minutes
6-10 minutes (but 80% of the maximum response is seen within 3
minutes.) Call anesthesia if there is no
desired clinical response with the administration of the initial
1 mg.
1-2 minutesIV bolus or infusion
Duration of Action
Peak EffectOnset of Action
Route
Reversal Flumazenil (Romazicon)Reversal Flumazenil (Romazicon)
![Page 15: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/15.jpg)
Copyright Ron Eslinger 2006
NarcoticsNarcotics
Narcotics– (commonly given along with Benzodiazepines) – are great potentiators of respiratory depression when
mixed. (great synergistic effect)Most Common– Morphine– Fentanyl– Demerol
![Page 16: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/16.jpg)
Copyright Ron Eslinger 2006
OpioidsOpioids
No amnestic effects
Provide analgesia and sedation
Adverse reactions: - Respiratory depression - Nausea and vomiting - Pruritis, urticaria- Urinary retention (young males) - Constipation
![Page 17: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/17.jpg)
Copyright Ron Eslinger 2006
MorphineMorphine
Dose is up to 0.15 mg/kg
Peak effect in 5-20 minutes, onset time less than one minute, duration 2-7 hours.
Possible histamine release, all of opioid side effects most possible with morphine.
![Page 18: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/18.jpg)
Copyright Ron Eslinger 2006
MorphineMorphine
6-12 hours1-2 hoursWithin 1 hourOral
4-7 hours30-60 minutes5 – 10 minutesIM
4-7 hours5 - 20 minutes<1 minuteIV
Duration of Action
Peak EffectOnset of Action
Route
![Page 19: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/19.jpg)
Copyright Ron Eslinger 2006
Meperidine (Demerol)Meperidine (Demerol)
One tenth the potency of morphine
IV dose is 0.5-1.0 mg/kg
Onset in less than one minute, peak effect in 5-20 minutes, duration 2-4 hours.
Caution in patients with renal/hepatic impairment, Monoamine oxidase inhibitors (MAOIs) (used for depression, isoniazid (TB Treatment)
![Page 20: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/20.jpg)
Copyright Ron Eslinger 2006
Meperidine (Demerol)Meperidine (Demerol)
2-4 hours60 minutes15-45 minutesOral
2-4 hours30-50 minutes1 – 5 minutesIM
2-4 hours5-20 minutes1 minutesIV
Duration of Action
Peak EffectOnset of ActionRoute
![Page 21: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/21.jpg)
Copyright Ron Eslinger 2006
Fentanyl (Sublimaze)Fentanyl (Sublimaze)
75-100 times more potent than morphine
Dose 0.7-1mcg/kg
Onset within 30 seconds, peak effect in 5-15 minutes, duration of effects 30-60 minutes
Titrate in 25 mcg increments
![Page 22: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/22.jpg)
Copyright Ron Eslinger 2006
Fentanyl (Sublimaze)Fentanyl (Sublimaze)
1-2 hours20 – 30 minutes
5-15 minutesTransmucosal
1-2 hours15-20 minutes5-8 minutesIM
30-60 minutes5-15 minutes<1 minuteIV
Duration of Action
Peak EffectOnset of Action
Route
![Page 23: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/23.jpg)
Copyright Ron Eslinger 2006
Naloxone (Narcan)Naloxone (Narcan)
Dose: 0.5-1.0 mcg/kg
All opioid effects, inclusive of analgesia, are reversed
Titrate to effect
Avoid rapid reversal - can lead to untoward sympathetic discharge, extreme pain, anxiety, pulmonary edema
![Page 24: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/24.jpg)
Copyright Ron Eslinger 2006
Reversal Naloxone (Narcan)Reversal Naloxone (Narcan)
1-4 hours5-15 minutes1-2 minutesIV
Duration of Action
Peak EffectOnset of Action
Route
![Page 25: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/25.jpg)
Copyright Ron Eslinger 2006
Ketamine (Ketamine (KetalarKetalar))
Dissociative anesthetic/analgesic agent
Derivative of phencyclidine(PCP)
Excellent analgesic and amnestic
![Page 26: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/26.jpg)
Copyright Ron Eslinger 2006
Ketamine (2)Ketamine (2)
Indications: Short term procedures requiring intense analgesia
Given IV by the operator, monitored by the monitor
Contraindications: many
![Page 27: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/27.jpg)
Copyright Ron Eslinger 2006
Ketamine (3)Ketamine (3)
Contraindications:• Increased ICP (increases ICP)• Corneal lacerations (increases intraocular
pressure)• Children with active URI (stimulates oral
secretions), psychiatric disorders (may cause extreme mood alteration), compromised airways (may induce apnea/anesthesia)
![Page 28: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/28.jpg)
Copyright Ron Eslinger 2006
Ketamine(4)Ketamine(4)
Recommended dosages: 0.25-0.5 mg/kg IV, 1-2 mg/kg IM
Onset of action IV <30 sec, IM 5-20 min; peak effect IV 1 min, IM 3-4 min; duration of action IV 5-15 min, IM 12-25 min
5 to 10 minutes
15 to 30 seconds
ImmediateIV
DurationPeak EffectOnset of Action
Route
![Page 29: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/29.jpg)
Copyright Ron Eslinger 2006
PropofolPropofol
DIPRIVAN (Propofol) is an intravenous sedative-hypnotic agent commercially introduced in the United States in 1989 by Zeneca Pharmaceuticals. It was the first of a new class of intravenous anesthetic agents - the alkylphenols.
5-10 minutes1 minute40 secondsIV
Duration of Action
Peak EffectOnset of Action
Route
![Page 30: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/30.jpg)
Copyright Ron Eslinger 2006
PropofolPropofol
Dosage/Administration – Adult dose: 25 – 50mg (0.5 – 1 mg/kg) IV, administered in 10 mg increments over several minutes. Pain on injection is decreased with IV lidocaine, 0.1 mg/kg, added to the diprivan emulsion. Strict aseptic technique must be maintained in handling, as diprivan is preservative free and will support bacterial growth. Diprivan injection should beprepared for single patient use only, just prior to the initiation of each procedure. Discard after opened for 6 hours.
Pediatric dose: 0.5 – 1.0mg/kg infused slowly and titrated to desired effect.
![Page 31: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/31.jpg)
Copyright Ron Eslinger 2006
Adverse ReactionsAdverse Reactions
Respiratory effects – respiratory depression, apnea, hiccup, bronchospasm, laryngospasm
Cardiovascular effects –hypotension, arrhythmia, tachycardia, bradycardia, hypertension
CNS effects – headache, dizziness, euphoria, myoclonic/clonic movement, seizures, sexual illusions.
![Page 32: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/32.jpg)
Copyright Ron Eslinger 2006
Emergency MedicationsEmergency Medications
Atropine: Increases heart rate by blocking vagal nerve stimulation. IV bolus 0.4-1.0 mg.
Lidocaine: Drug of choice for ventricular dysrhythmias -decreases automaticity. IV bolus 50-100 mg.
Ephedrine: Increases blood pressure and heart rate by indirect cardiac stimulation. IV bolus 5-10 mg.
![Page 33: Medications Used for Sedation...Qsedative - hypnotic in large doses Qpatients who chronically take Cimetidine (Tagamet) or Ranitidine (Zantac) are especially susceptible to Benzodiazepine](https://reader035.vdocuments.mx/reader035/viewer/2022070918/5fb81c1ef008002a193c8e2c/html5/thumbnails/33.jpg)
Copyright Ron Eslinger 2006
Questions
www.sedationcertification.com