![Page 1: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/1.jpg)
JPND and Healthy Diet for Healthy Life
Marlies DorlöchterMember of the JPND Management and Executive Board
12/11/2014
![Page 2: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/2.jpg)
We cannot tackle neurodegenerative diseases by acting as single countries
AlbaniaAustria
BelgiumCanadaCroatia
Czech RepublicDenmarkFinlandFrance
GermanyGreeceHungaryIrelandIsraelItaly
LuxembourgNetherlands
NorwayPoland
PortugalRomaniaSlovakiaSlovenia
SpainSweden
SwitzerlandTurkey
United Kingdom
JPND is the largest global ND research initiative led by countries, with 28 participatingEU member statesAssociated countries Third countries
Increasing coordination of national research programmes to improve impact and effectiveness
![Page 3: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/3.jpg)
The JPND goals
To tackle the challenge of Alzheimer’s and other neurodegenerative diseases, the goals of the JPND Research Strategy are:
• To develop new treatments and preventive strategies
• To improve health and social care approaches
• To raise awareness and de-stigmatise neurodegenerative disorders
• To alleviate the economic and social burden of these diseases
![Page 4: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/4.jpg)
Neurodegenerative Diseases?
• The neurodegenerative diseases that JPND focuses on are:
• Alzheimer’s disease (AD) and other dementias• Parkinson’s disease (PD) and PD-related disorders• Prion disease• Motor neurone diseases (MND)• Huntington’s Disease (HD)• Spinocerebellar ataxia (SCA)• Spinal muscular atrophy (SMA)
![Page 5: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/5.jpg)
Scope of JPND Research
Scientific Animal models Biobanks Cohorts/registries Disease pathology
Scientific Animal models Biobanks Cohorts/registries Disease pathology
Social Health care delivery Home automation Health economics Ethics
Social Health care delivery Home automation Health economics Ethics
Medical Early diagnosis Prevention Clinical trials
Medical Early diagnosis Prevention Clinical trials
![Page 6: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/6.jpg)
Defragmentation – what JPND is all about…
STRATEGIC RESEARCH AGENDA
ALIGNMENT OF COUNTRIESON COMMON RESEARCH GOALS
![Page 7: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/7.jpg)
JPND Research Strategy (SRA)
• Agreed by all JPND Member States + Assoc. Countries
• Officially Launched Feb 7th 2012
• Thematic priorities for future research:
• The origins of neurodegenerative disease
• Disease mechanisms and models
• Disease definitions and diagnosis
• Developing therapies, preventive strategies and interventions
• Healthcare and social care
![Page 8: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/8.jpg)
JPND Research Strategy (SRA)
•SRA Enabling Activities:• JPND will deliver the SRA within the next ten years through a combination of:
• Knowing our research capability• Opportunities for infrastructure and platforms • Working in partnership with industry• Working with the regulators• Global partnership• Capacity building• Education and training• Connection to policy makers• Communication and outreach
![Page 9: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/9.jpg)
SRA Implementation (2012-2014)
Annual Calls for Proposals
Year Total fund available
Research Area No. of Projects
2011(pilot)
€14M Optimization of biomarkers + harmonization of their use
4
2012 €17M Risk and Protective Factors 5
2012 €9M Evaluation of Healthcare 6
2013 €12.5M Cross-Disease Analysis 10
2013 €7M Preventive Strategies 5
2014 €0.5M Working groups on longitudinal cohort studies10
Total €60M 40
![Page 10: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/10.jpg)
JPND Alignment Actions
• JPND Action Groups for:
![Page 11: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/11.jpg)
Action Group Recommendations
![Page 12: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/12.jpg)
Partnership with the EC
• Synergy between JPND actions and H2020 programme
• ERA-NET cofund: Implementing a transnational call with EU co-funding
• Call on three Topics for 2015
• Genetic, epigenetic and environmental risk + protective factors
• Longitudinal cohorts in ND research
• Advanced experimental models of ND
![Page 13: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/13.jpg)
Collaboration with JPI HDHL
• Shared goals and activities
• Possible collaboration
![Page 14: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/14.jpg)
Potential Next Steps
• Arrange a small scientific working group • SAB-based?
• Determine potential areas of collaboration
• Identify possible actions
• Report back to JPND and HDHL
• Announce HDHL activities on JPND website?
![Page 15: Marlies Dorlochter slides - JPI-HDHL meeting, Nov 2014](https://reader033.vdocuments.mx/reader033/viewer/2022052908/559666e11a28abe8048b45ec/html5/thumbnails/15.jpg)
Keep up to date
• Visit the JPND website:• http://www.jpnd.eu
• Sign up to the JPND News Feeds
• E-mail us: [email protected]
• Follow us on Twitter:
@JPNDEurope