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Lynch syndrome -What is it?
Lynch Syndrome Australia
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Just bad luck?
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What is Lynch Syndrome?
Lynch syndrome (previously known as HNPCC) is an inherited genetic mutation which gives people an increased chance of developing certain cancers across their lifetime, often at a younger age than the general population (i.e. before 50 years of age).
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The numbers4
Lynch syndrome is caused by a mutation in one of the body’s mismatch repair (MMR)genes. These genes are:
MLH1, MSH2, MSH6, and PMS2.
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12
• Colon* and rectal cancer• Endometrial cancer*• Small intestine cancer (MSH2 &
MLH1)• Hepato-biliary and pancreatic
cancer (MSH2 & MLH1)• Gastric cancer (MSH2 & MLH1)• Ovarian non-serous cancer (MSH2 &
MLH1)
*Most common cancers associated with Lynch syndrome.
• Renal pelvis and ureter cancer (MSH2 & MSH6)
• Bladder cancer(MSH2 & MSH6)• Sebaceous gland cancer (and
adenoma – Muir-Torre syndrome)• Prostate cancer (MSH2)• Breast cancer (MLH1)• Central nervous system cancer
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The numbers
1:280
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The numbers
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When would you suspect Lynch syndrome?
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•Comprehensive Family History
•Tumour testing
•Genetic Counselling
•Mutation search
•Predictive testing
Diagnosis
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Risk
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Management
Current management/surveillance of Lynch syndrome in Australia is based on the EviQGuidelines
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EviQ guidelines
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EviQ guidelines
https://www.eviq.org.au/cancer-genetics/risk-management/1410-risk-management-for-lynch-syndrome
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The Lynch syndrome patient with cancer
•Cancers occur younger than the population
• More than one cancer
•Treatment options
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The role of the Practice Nurse
•Take a comprehensive family history
• Regularly review the family history
•Coordinating surveillance
•Understanding where to find more information
• Emotional support
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Raising awareness
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Resources
• Understanding genetic tests for Lynch syndrome-Information and decision aid
• Lynch Syndrome Australia
• NSW Cancer Institute
• Cancer Council NSW
• Cancer Australia
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Lynch Syndrome Australia
• Living with Lynch syndrome workshops
• Peer to peer support group
• Comprehensive website
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Lynch Syndrome Australia Report
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Thank You
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lynchsyndrome.org.au