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JeopardyPhases of Wound Healing
Heritable Diseases
Specific Tissues
Factors affecting wound healing
Treatment
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Final Jeopardy
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$100 Question from H1
Name the three phasesof wound healing.
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$100 Answer from H1
a. Hemostasis and inflammationb. Proliferationc. Maturation and remodeling
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$200 Question from H1
In the hemostasis phase, these arethe first infiltrating cells to enterthe wound site, peaking at 24 to 48hours.
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$200 Answer from H1
PMNs
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$300 Question from H1
In the proliferation phase, these cellsproliferate extensively and participatein the formation of new capillaries?
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$300 Answer from H1
Endothelial cells
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$400 Question from H1
They couple with proteins to form proteoglycans, and compromise a largeportion of the “ground substance” that makes up granulation tissue.
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$400 Answer from H1
Glycosaminoglycans
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$500 Question from H1
Breaks down collagen in the maturationand remodeling phase.
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$500 Answer from H1
Matrix metalloproteinases (MMPs)
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$100 Question from H2
Genetic defect is in an extracellular protein,fibrillin, and presents with tall stature, arachnodactyly, lax ligaments, pectusexcavatum, and aneurysms.
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$100 Answer from H2
Marfan’s Syndrome
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$200 Question from H2
Defect in collagen formation. Thin, friableSkin with prominent veins. Associated with GI problems
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$200 Answer from H2
Ehler-Danlos Syndrome
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$300 Question from H2
Mutation in Type I collagen, four major subtypes, dermal thining and increasedbruisability.
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$300 Answer from H2
Osteogenesis Imperfecta
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$400 Question from H2
Classified into 3 major subtypes. impairment in tissue adhesion within the epidermis, basement membrane, or dermis, resulting in tissue separation.
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$400 Answer from H2
Epidermolysis Bullosa
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$500 Question from H2
An autosomal recessive disease of childrenthat causes an inability to absorb sufficient zinc from breast milk or food. Impaired granulation tissue formation.
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$500 Answer from H2
Acrodermatitis Enteropathica
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$100 Question from H3
The early integrity of a bowel anastamosis isdependent on formation of a fibrin seal on theserosal side, which achieves watertightness, and on the suture-holding capacity of the intestinal wall, particulary which layer?
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$100 Answer from H3
Submucosal layer
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$200 Question from H3
With a nerve injury, these cells ensheatheand help in remyelinating the regeneratingaxons.
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$200 Answer from H3
Schwann cells
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$300 Question from H3
What is the main characteristic that distinguishes the healing of fetal woundsfrom that of adult wounds?
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$300 Answer from H3
Scar formation
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$400 Question from H3
Cartilage consists of these cells, surroundedby an extracellular matrix made up of several proteoglycans, collagen fibers, and water.
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$400 Answer from H3
Chondrocytes
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$500 Question from H3
The fetal wound is characterized by excessiveand extended production of what glycosaminoglycan?
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$500 Answer from H3
Hyaluronic Acid
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$100 Question from H4
This medication inhibits the inflammatoryphase of wound healing and the release of lysosomal enzymes.
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$100 Answer from H4
Steroids
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$200 Question from H4
The best known of the metabolic disorderscontributing to increased rates of woundinfection and failure.
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$200 Answer from H4
Diabetes Mellitus
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$300 Question from H4
What perioperative measure can be takento decrease wound infection rate by 66%?
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$300 Answer from H4
Prophylactic antibiotics
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$400 Question from H4
This deficiency impairs wound healing, while supplement benefits wound healingin nondeficient humans and animals.
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$400 Answer from H4
Vitamin A
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$500 Question from H4
With this deficiency, there is decreasedfibroblast proliferation, decreased collagensynthesis, impaired overall wound strength,and delayed epithelialization.
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$500 Answer from H4
Zinc
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$100 Question from H5
This dressing uses negative pressure to increase the rate of wound healing by increasing blood flow to subcutaneous tissues.
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$100 Answer from H5
V.A.C. Dressing
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$200 Question from H5
List a complication of sulfamylontreatment.
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$200 Answer from H5
Metabolic acidosis
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$300 Question from H5
This is a serious complication of Silvadene application.
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$300 Answer from H5
Leukopenia and Neutropenia
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$400 Question from H5
This treatment has a serious complicationof hyponatremia and methemoglobinemia.
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$400 Answer from H5
Siver nitrate
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$500 Question from H5
These two concepts are critical in selecting appropriate dressing.
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$500 Answer from H5
Occlusion and absorption
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Final Jeopardy
Who were the first people to differentiatebetween infected and diseased wounds compared to noninfected wounds?
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Final Jeopardy Answer
The Egyptians