PACCARB, Washington27th February 2020
Leon Marchal, PhDInnovation Director
Innovations in Animal Feed (Additives)
Dupont Animal Nutrition, part of Nutrition & Biosciences
Porzyme® & Avizyme®
First species-specific multi-enzyme solutions
1984Firstß-glucanaseenzyme
2006Avicheck®
Phycheck®
services
Betafin®First betaine for Choline sparing
2003
Phyzyme® XPFirst E. coliphytase
2007
Phyzyme® XP TPTPorcheck®
software tool
1988
1997Avizyme® 1500Carbohydrase/ protease blend
MicroTreatP ProvalenProbiotics for poultryCSI - Gut microbial analysis service for poultry and swine
2008
1982
Feed enzyme development begins
1979 2011Axtra® XBAxtra® XAPCarbohydrasesfor complex diets
2018
2014OptimizeFeed® Service
2015
Syncra®AVIenzyme-probiotic combination
2019Enviva® PROProbiotic for broilersSyncra® SWIAdaptive protease/ probiotic solution
2013
Axtra® PHYFastest phytase
Axtra® PROLeadingprotease
Enviva® EO launchphytogenic blend
2010
2017CSI 2.0Fecal microbial analysis service for poultry and swine
2
Animal Nutrition group of Wageningen University
Fundamental understanding ofnutritional processes and
the effects on the health, growth, welfareand longevity of animals.
What needs to happen forantibiotic (growth promotor) free production
Nutrition
Hygiene
Gut & Immune Function Microbiome
3
Imag
e: T
ed
Feed structure – better organ development
Images: ForFarmers
ain15% whole gr
Pelleting
Experimental groupControl (starconcept 0%)
Trial (starconcept 15%)100% diet
Pelleting
Grinding Grinding
100% diet
Adding a few % fiber structure toa broiler diet
Image:Nutreco
ReviewsThe gizzard: function, influence of diet structure and effects on nutrient availability
B.SVIHUSDepartment of Animal and Aquacultural Sciences,Norwegian University of Life Sciences, World's Poultry Science Journal, Vol. 67, June 2011
Better organ development Beneficial for ‘right flora in
the right place’ Same or better feed
conversion
4
Similar feed conversion Better stomach function Less prone to
Salmonella infections
Stomach Score
Less overfeeding of protein• Protein digestion is generally 60-90%• Younger animals have generally lower digestibility• Raw material quality also varies in practice
All the protein that is not digested in the small intestine is potentially
fermented by pathogens in the large intestine
5Protein digestion kinetics in pigs and poultry, H.Chen (2017)
Hydrolytic enzymes improve (protein) digestibility• Phytases are the most commonly used enzyme, globally
• Competition drives increased efficacy & reduced costs higher inclusion levels
7877
79
8182
83
PC NC 250 500 1000 2000
Phytase, FTU/kg
%
Amin
o ac
id d
iges
tibilit
y
P linear < 0.0001
179
180
181
182
183
184
185
186
187
0 250 500 750 1000 1250 1500 1750 2000
Phytase dose (FTU/kg feed)
E-ColiButtiauxella
Other enzymes used in animal production: xylanases, beta-glucanases, amylases, proteases6
Animal Feed Science and Technology 253 (2019) 166–180J. Anim. Sci. 2019.97:2524–2533Am
ino
acid
dig
estib
ility
(g/k
g di
et)
DFM / probiotic maintain general gastrointestinal health
7
C
d
ompetitive exclusion
Compete for ecological
niches
Stimulate
Compete for nutrients
efense by host
Immunomodulation
Regulate proinflammatory
cytokines
Stimulate immune response
Enhance beneficial microbiota
Inhibition of virulence factors
Decrease luminal pH
Secrete bacteriocidalmolecules
Direct microbial
interactions
What are DFM / probiotics capable of?
8
Support the development of a healthy gut (immune system, gut function and microbiota development)
Support the recovery post-infection
Can have antimicrobial activity against other microbes (typically broad spectrum)
Add to the overall fermentation and can produce beneficial metabolites
NOT a drug
NOT a true replacement for therapeutic antibiotics
Probiotics can Probiotics are
Innovations in Animal Feed (Additives)
A combination of feed additives and feeding more precisely can reduce the need of antibiotics drastically (EU and market examples).
Further antibiotic reduction needs the development of more consistent feed additive solutions.
Key is increasing the robustness of the animals.
We should conserve the efficacy of antibiotics for when they are really needed when animals despite all measures become sick (animal welfare).
9
Copyright © 2020 DuPont. All rights reserved. DuPont™, the DuPont logo and all products denoted with ® or ™ are trademarks of theaffiliates of DuPont de Nemours, Inc. The information contained herein is subject to change without further notice, is provided at therequest of and without charge to our customers and is based upon data DuPont believes to be reliable. Conditions and methods ofuse of the products are beyond our control, and nothing contained herein shall be construed as a representation or warranty on use orof non-infringement of intellectual property, regulatory or legal compliance. If this presentation is provided in any language other thanEnglish, the original English version will control, and DuPont hereby disclaims responsibility for any errors caused by translation.