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05/11/2008
Foot plant gangrene
Reconstruction of the foot
Emilio Calabrese MD.International Center for Limb Salvage
www.gfmer.ch/ICLS/Homepage.htm
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05/11/2008
Right foot
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Clinical information
Diabetic Patient
Previous treatments performed
elsewhere:
• Intravenous antibiotics
• Hyperbaric chamber
• Advanced local wound treatment
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Admission to National Center for Limb Salvage
A: Treatment progress:
General assessment Decompensated Diabetes
• Insulin adjustment
• Fluid and electrolyte balance
Mild to moderate Acute Renal failure
Arteriography Gaseous Contrast (Carbon Dioxide)
integrated by Iodinated Contrast.• Gas was used to reduyce further damage
to an already impaired renal function
Angioplasty Insertion of Self Expanding Stent in the
Femoral Artery.
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Arteriography
Arteriography with Iopamiro 300Non-ionic iodinated contrast media
Short severe stenosis of the superficial femoral artery
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Percutaneous Transluminal Angioplasty
Procedure performed in part by using Carbon Dioxide
This was done to reduce the total amount of non-ionic
iodine contrast thus minimizing further renal damage.
Stenosis of the Superficial Femoral Artery
Angioplasty balloon inserted and
inflated at a pressure of 8 Atmospheres
Balloon inflated at 16 Atmospheres
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Insertion of BS 6 mm self-expandable stent Symphony
stent
CO2 Arteriography
Highly soluble Carbon Dioxide gas is injected in the femoral artery
To visualize results of Angioplasty.
Gaseous contrast does not produce renal toxicity
Stent inserted in
the femoral arteryArterial flow is verified
by injecting Carbon Dioxide
Verification of adequate flow
in the vessels below the knee
with Carbon Dioxide Injection
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Comments:
A single, simple stenosis of the Superficial Femoral Artery alone in a non-diabetic patient rarely produce gangrene.
but…:
A stenosis of the femoral artery may help severe gangrene develop in diabetic patients who develop infections or in patients who have chronic renal failure
Treating the stenosis is essential to increase blood flow to the foot
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after successful Stenting and correction of the stenosis...
B: Treatment progress: Surgical debridement
• Anesthesia
• Surgical resection of necrotic and infected tissue from the foot
Cultures and sensivities• Identification fo prevalenty bacteria by
– Gram stain
– Aerobic and anaerobic culture
– Antibiotic testing in vitro
• Specific Antibiotic treatment
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Foot before PTA
July 21, 1998
Plant of fooot before PTA and surgical debridement
July 29, 1998
Plant of foot 1 week after PTA and Debridement
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Comments
Restoring blood flow alone by angioplasty
IS NOT ENOUGH
to save the foot and prevent amputation!
Further immediate treatment is necessary...
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Admission to
National Center for Limb Salvage
C: Treatment progress: Long term local wound treatment
• Daily surgical cleaning
• Medication of wound with
– 10% diluted Povidone Iodine (Betadine®)
Foot reconstruction
Rehabilitation
Follow-up controls
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September 8, 1998
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D: Treatment progress:
Foot reconstruction
• Skin Tranplant
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05/11/2008September 16, 1998
Shortly after Skin Transplant to the foot
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E: Treatment progress:
Rehabilitation
Follow-up controls
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05/11/2008 July 20, 1999
1 year post PTA
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October 18, 1999
15 months post PTA
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05/11/2008
July 1998 – October 1999
Functional foot with normal walking capabilities
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05/11/2008November 3, 2000
2 ½ years post PTA
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05/11/2008 3-year post stenting : PRIMARY PATENCY and no recurrent foot ulcer
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F: Treatment progress:
Long-term follow-up controls
Strict control of diabetes
Foot hygiene
Footwear accurately chosen
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Follow-up care
F: Treatment progress:
Life-long yearly medical work-up of
patients
Diabetes surveillance
Appropriate hygiene
Diet and weight control
Proper foot ware and preventive care
Repeated early intervention for
recurrent arterial disease
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Conclusions
Even with extensive foot plant gangrene an effective limb salvage is feasible
Anatomical and functional results can both be satisfactory
Hyperbaric chamber may help, but it should not be considered a mainstay in the treatment of gangrene in diabetic patients: it should be better considered no more than an accessory aid to avoid dispersion of resources. Literature data on the effect of Hyperbaric Oxygen on non-clostridial infections
are at best controversial
When concentrating on hyperbaric Oxygen therapy, one may focus less attention on much more important therapeutic maneuvers which could be more determinant in the limb salvage process.
Priority should be given to re-vascularization, aggressive debridement, foot reconstruction, diabetes control and nutritional support, accurate microbiology and well chosen antibiotics, logistic and psychological support to the patient and his/her family.
Hyperbaric chamber probably accelerates the growth of granulation tissue, thus helping speed the healing process, but only when the problem of infection and poor blood supply has been solved by more effective means.
More often than not, a diabetic limb can be salvaged without Hyperbaric chambers.
Rarely can one save a limb with the sole use of Hyperbaric Oxygen.