Leif GroopLunds Universitets DiabetescentrumFinnish Institute for Molecular Medicine
Diabetesjukdomens maringnga ansikten-steg mot individualiserad behandling
Sveriges Endokrinologfoumlrening Umearing 30 januari 2019
SDR (7512)Skaringne Diabetes Register
ANDISANDIUAll New Diabetics In SkaringneUppsala
19086 880
httpandisludcmedluse
DIREVA (6139)Diabetes Register Vasa
ANDIS- All New Diabetics in ScaniaA Traditional classificationB Cluster-based classification
Age at diagnosisBMIHbA1cGADAC-peptide (HOMA-B)HOMA-IS)
ANDIS Hierarchical clustering and silhouette analysis
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden Det garingr inte att visa bilden
Men n=5334 Women n=3646
Replication Diabetes Registry VAasaDIREVA Finland
Det garingr inte att visa bilden
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden
Diabetes duration lt 2 years N=878 Diabetes duration 10plusmn10 years N=2607
Replikerad i Peking KinaDet garingr inte att visa bilden
Xou X et al Lancet DampE 2019
SAIDSevere autoimmune diabetes
bull 64 of patientsbull All GADA positive = T1D+LADAbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SAID Mean (SD)
HBA1C at diagnosis mmoll 80 (31)
BMI kgm2 27 (6)Age at diagnosis years 50 (18)
HOMA2B 57 (45)HOMA2IR 22 (16)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
SIDDSevere insulin-deficient diabetes
bull 175 of patientsbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SIDD Mean (SD)
HBA1C at diagnosis mmoll 102 (19)
BMI kgm2 29 (5)Age at diagnosis years 57 (11)HOMA2B 48 (29)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
SDR (7512)Skaringne Diabetes Register
ANDISANDIUAll New Diabetics In SkaringneUppsala
19086 880
httpandisludcmedluse
DIREVA (6139)Diabetes Register Vasa
ANDIS- All New Diabetics in ScaniaA Traditional classificationB Cluster-based classification
Age at diagnosisBMIHbA1cGADAC-peptide (HOMA-B)HOMA-IS)
ANDIS Hierarchical clustering and silhouette analysis
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden Det garingr inte att visa bilden
Men n=5334 Women n=3646
Replication Diabetes Registry VAasaDIREVA Finland
Det garingr inte att visa bilden
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden
Diabetes duration lt 2 years N=878 Diabetes duration 10plusmn10 years N=2607
Replikerad i Peking KinaDet garingr inte att visa bilden
Xou X et al Lancet DampE 2019
SAIDSevere autoimmune diabetes
bull 64 of patientsbull All GADA positive = T1D+LADAbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SAID Mean (SD)
HBA1C at diagnosis mmoll 80 (31)
BMI kgm2 27 (6)Age at diagnosis years 50 (18)
HOMA2B 57 (45)HOMA2IR 22 (16)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
SIDDSevere insulin-deficient diabetes
bull 175 of patientsbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SIDD Mean (SD)
HBA1C at diagnosis mmoll 102 (19)
BMI kgm2 29 (5)Age at diagnosis years 57 (11)HOMA2B 48 (29)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
ANDIS- All New Diabetics in ScaniaA Traditional classificationB Cluster-based classification
Age at diagnosisBMIHbA1cGADAC-peptide (HOMA-B)HOMA-IS)
ANDIS Hierarchical clustering and silhouette analysis
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden Det garingr inte att visa bilden
Men n=5334 Women n=3646
Replication Diabetes Registry VAasaDIREVA Finland
Det garingr inte att visa bilden
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden
Diabetes duration lt 2 years N=878 Diabetes duration 10plusmn10 years N=2607
Replikerad i Peking KinaDet garingr inte att visa bilden
Xou X et al Lancet DampE 2019
SAIDSevere autoimmune diabetes
bull 64 of patientsbull All GADA positive = T1D+LADAbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SAID Mean (SD)
HBA1C at diagnosis mmoll 80 (31)
BMI kgm2 27 (6)Age at diagnosis years 50 (18)
HOMA2B 57 (45)HOMA2IR 22 (16)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
SIDDSevere insulin-deficient diabetes
bull 175 of patientsbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SIDD Mean (SD)
HBA1C at diagnosis mmoll 102 (19)
BMI kgm2 29 (5)Age at diagnosis years 57 (11)HOMA2B 48 (29)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
ANDIS Hierarchical clustering and silhouette analysis
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden Det garingr inte att visa bilden
Men n=5334 Women n=3646
Replication Diabetes Registry VAasaDIREVA Finland
Det garingr inte att visa bilden
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden
Diabetes duration lt 2 years N=878 Diabetes duration 10plusmn10 years N=2607
Replikerad i Peking KinaDet garingr inte att visa bilden
Xou X et al Lancet DampE 2019
SAIDSevere autoimmune diabetes
bull 64 of patientsbull All GADA positive = T1D+LADAbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SAID Mean (SD)
HBA1C at diagnosis mmoll 80 (31)
BMI kgm2 27 (6)Age at diagnosis years 50 (18)
HOMA2B 57 (45)HOMA2IR 22 (16)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
SIDDSevere insulin-deficient diabetes
bull 175 of patientsbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SIDD Mean (SD)
HBA1C at diagnosis mmoll 102 (19)
BMI kgm2 29 (5)Age at diagnosis years 57 (11)HOMA2B 48 (29)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
Replication Diabetes Registry VAasaDIREVA Finland
Det garingr inte att visa bilden
Det garingr inte att visa bildenDet garingr inte att visa bilden
Det garingr inte att visa bilden
Diabetes duration lt 2 years N=878 Diabetes duration 10plusmn10 years N=2607
Replikerad i Peking KinaDet garingr inte att visa bilden
Xou X et al Lancet DampE 2019
SAIDSevere autoimmune diabetes
bull 64 of patientsbull All GADA positive = T1D+LADAbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SAID Mean (SD)
HBA1C at diagnosis mmoll 80 (31)
BMI kgm2 27 (6)Age at diagnosis years 50 (18)
HOMA2B 57 (45)HOMA2IR 22 (16)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
SIDDSevere insulin-deficient diabetes
bull 175 of patientsbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SIDD Mean (SD)
HBA1C at diagnosis mmoll 102 (19)
BMI kgm2 29 (5)Age at diagnosis years 57 (11)HOMA2B 48 (29)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
Replikerad i Peking KinaDet garingr inte att visa bilden
Xou X et al Lancet DampE 2019
SAIDSevere autoimmune diabetes
bull 64 of patientsbull All GADA positive = T1D+LADAbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SAID Mean (SD)
HBA1C at diagnosis mmoll 80 (31)
BMI kgm2 27 (6)Age at diagnosis years 50 (18)
HOMA2B 57 (45)HOMA2IR 22 (16)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
SIDDSevere insulin-deficient diabetes
bull 175 of patientsbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SIDD Mean (SD)
HBA1C at diagnosis mmoll 102 (19)
BMI kgm2 29 (5)Age at diagnosis years 57 (11)HOMA2B 48 (29)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
SAIDSevere autoimmune diabetes
bull 64 of patientsbull All GADA positive = T1D+LADAbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SAID Mean (SD)
HBA1C at diagnosis mmoll 80 (31)
BMI kgm2 27 (6)Age at diagnosis years 50 (18)
HOMA2B 57 (45)HOMA2IR 22 (16)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
SIDDSevere insulin-deficient diabetes
bull 175 of patientsbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SIDD Mean (SD)
HBA1C at diagnosis mmoll 102 (19)
BMI kgm2 29 (5)Age at diagnosis years 57 (11)HOMA2B 48 (29)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
SIDDSevere insulin-deficient diabetes
bull 175 of patientsbull High HbA1cbull Low insulin secretionbull Relatively leanbull Relatively young
SIDD Mean (SD)
HBA1C at diagnosis mmoll 102 (19)
BMI kgm2 29 (5)Age at diagnosis years 57 (11)HOMA2B 48 (29)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
0
002
004
006
008
01
012
014
016
1SAID 2SIDD 3SIRD 4MOD 5MARD
Proliferative
Non proliferative
Severe
Moderate
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS ANDIU
SIDD vs MARD OR 16 p=97x10-7 OR 46 p=41x10-13
SIDDSevere insulin-deficient diabetes
Diabetic retinopathy
Neuropathy is also increased in this group
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
Hba1
c m
mol
LHbA1c over time
Ketoacidosis at diagnosis
SIDDSevere insulin-deficient diabetes
ZnT8A auto-antibodiesGene - SNP SAID (N=313) SIDD (N=676)
OR P OR P
HLA DQB1 - rs2854275 205 57x10-10 082 008
HLA DQB1 - rs9273363 033 20x10-32 108 037
TCF7L2 - rs7903146 117 008 15
1 28x10-10
Genetics ndash cluster vs non-diabetic controls (N=2754)
0
005
01
015
02
025
03
035
1SAID 2SIDD 3SIRD 4MOD 5MARD
0
005
01
015
02
025
03
1SAID 2SIDD 3SIRD 4MOD 5MARD
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
ANDIS eGFRlt45 mLmin173m2
SDR Macroalbuminuria
SDR ESRD
eGFRlt15 mLmin173m2
HR(CI95) p
1SAID 10 (06-19) 098
2SIDD 17(12-25) 0003
3SIRD 33(26-43) 8x10-21
4MOD 17(10-30) 0045
HR(CI95) p
04(01-10) 0056
13(07-22) 039
22(13-36) 0003
13(07-24) 0371 -
HR(CI95) p19(07-53) 02323(11-46) 0024
49(27-89) 24x10-7
17(07-44) 0251 -
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
1-cu
mul
ativ
e su
rviv
al
SIRDSevere insulin-resistant diabetes
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
bull 216 of patientsbull Low HbA1cbull Very obesebull Relatively youngbull Low risk of complicationsMOD Mean (SD)
HBA1C at diagnosis mmoll 58 (16)
BMI kgm2 36 (5)Age at diagnosis years 49 (10)
HOMA2B 95 (32)HOMA2IR 34 (12)
MODModerate obesity-related diabetes
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
MODModerate obesity-related diabetes
Gene - SNP 3SIRD (N=603) 4MOD (N=727)
OR P OR P
TM6SF2 - rs10401969 062 31x10-6 089 026
TCF7L2 - rs7903146 100 086 138 57x10-7
JAZF1 ndash rs864745 093 014 081 18x10-4
KCNJ11 ndash rs5219 103 067 128 12x10-4
Genetics ndash cluster vs non-diabetic controls (N=2754)
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
MARDModerate age-related diabetes
bull 391 of patientsbull Low HbA1cbull Relatively oldbull Relatively leanbull Low risk of complicationsMARD Mean (SD)
HBA1C at diagnosis mmoll 50 (10)
BMI kgm2 28 (3)Age at diagnosis years 67 (9)
HOMA2B 87 (26)HOMA2IR 26 (08)
HBA1C BMI AGE
HOMA2-B HOMA2-IRDet garingr inte att visa bilden
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
Emma Ahlqvist
296 kommentarer i internationell press de foumlljande 5 dagarna
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
En app foumlr diabetesmottagningenbaserad paring maskinlaumlrning
Olof Asplund
Naumlsta steg
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-
TACK foumlr uppmaumlrksamheten
Naumlr foumlraumlndringens vindar blaringser aumlr det baumlttre med vaumlderkvarnar aumln vindskydd
- Bildnummer 1
- Bildnummer 2
- Bildnummer 3
- ANDIS Hierarchical clustering and silhouette analysis
- Replication Diabetes Registry VAasaDIREVA Finland
- Bildnummer 6
- SAID Severe autoimmune diabetes
- SIDDSevere insulin-deficient diabetes
- Bildnummer 9
- Bildnummer 10
- Bildnummer 11
- Bildnummer 12
- Bildnummer 13
- MARDModerate age-related diabetes
- Bildnummer 15
- Bildnummer 16
- Bildnummer 17
-