contents continued from outside back cover

Toxicokinetics of αα-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice

Suramya Waidyanatha , Jerry D. Johnson , S. Peter Hong , Veronica Godfrey Robinson , Seth Gibbs , Steven W. Graves , Michelle J. Hooth , Cynthia S. Smith . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways

Minh Truong Do , Hyung Gyun Kim , Tilak Khanal , Jae Ho Choi , Dong Hee Kim , Tae Cheon Jeong , Hye Gwang Jeong . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229

Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling

Young-Ok Son , Poyil Pratheeshkumar , Lei Wang , Xin Wang , Jia Fan , Dong-Hern Kim , Ju-Yeon Lee , Zhuo Zhang , Jeong-Chae Lee , Xianglin Shi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239

Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles

Jackye Peretz , Jodi A. Flaws . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249 Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway

Yi Wang , Wei Wei , Yuan Wang , Jing Dong , Binbin Song , Hui Min , Weiping Teng , Jie Chen . . . . . . 257 Comparative developmental toxicity of environmentally relevant oxygenated PAHs

Andrea L. Knecht , Britton C. Goodale , Lisa Truong , Michael T. Simonich , Annika J. Swanson , Melissa M. Matzke , Kim A. Anderson , Katrina M. Waters , Robert L. Tanguay . . . . . . . . . . . . . . . . . . . 266

Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fi brosis

Katrien Van Beneden , Caroline Geers , Marina Pauwels , Inge Mannaerts , Karl M. Wissing , Christiane Van den Branden , Leo A. van Grunsven . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276

JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats

Xinjin Guo , Qiang Meng , Qi Liu , Changyuan Wang , Huijun Sun , Jinyong Peng , Xiaochi Ma , Taiichi Kaku , Kexin Liu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285