Download - Community Acquired MRSA & Animal Bites
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Methicillin resistance in S. aureus is defined as an Oxacillin (MIC) > 4microgram/mL. Isolates resistant to oxacillin or methicillin are alsoresistant to all beta - lactam agents including cephalosporins.
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The mecA gene responsible for methicillin resistance
Staphylococcal cassette chromosome (SCCmec).
There are five SCCmec types (I-V) that vary in geneticmakeup and size.
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Hospital AssociatedMRSA
Community Associated MRSA
HA - MRSA CA - MRSA
type I, II, or III SCCmec type IV SCCmec
Multiple antibiotic resistance
does not carry the multiple antibiotic resistance
Sensitive to Bactrim, Clindamycin & 50% fluoroquinolones.
Panton-Valentine leukocidin•SCCmec type IV CA-MRSA •skin •soft tissue•necrotizing pneumonia •MRSA USA300Prolonged hospitalization
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12-29%
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Prior skin infection
Previous antibiotic use
Illicit drug use
Tattoo recipients
Prison residence
Military personnel
A higher body mass index
Cosmetic body shaving
Physical contact with a person who has a draining lesion or is a carrier of MRSA
Sharing equipment that is not cleaned or laundered between users
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Antibiotic use within three months before admission.
Hospitalization during the past 12 months.
Diagnosis of skin or soft-tissue infection at admission
HIV infection
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Skin or soft tissue infections.
Necrotizing pneumonia.
Necrotizing fasciitis
Rapidly fatal septicemia
Endocarditis
Osteomyelitis
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