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Cluster of Orthologous Cluster of Orthologous Groups (COGs)Groups (COGs)
Harold ArdilaHarold Ardila
Carlos A. NiñoCarlos A. Niño
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COGsCOGs• Ortólogos son genes que se encuentran en Ortólogos son genes que se encuentran en
diferentes especies y provienen de un gen diferentes especies y provienen de un gen ancestral común. Generalmente presentan la ancestral común. Generalmente presentan la misma función a través de la evolución.misma función a través de la evolución.
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COGsCOGs
• Cada COG se define como el grupo de tres Cada COG se define como el grupo de tres o más proteínas que son o más proteínas que son OrtólogasOrtólogas
• Han sido desarrollados mediante la Han sido desarrollados mediante la comparación, todos contra todos, de comparación, todos contra todos, de secuencias de proteínas codificadas en secuencias de proteínas codificadas en genomas completos secuenciados, genomas completos secuenciados, utilizando el programa BLAST.utilizando el programa BLAST.
• 5666 COGs (unicelulares)5666 COGs (unicelulares)
• 4852 KOGs (eucariotas)4852 KOGs (eucariotas)
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ACCESO
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1 2
1.COGs – UNICELULARES
2.KOGs - EUCARIOTES
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Phyla
ORDEN
Taxonomy DB
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EUKARIOTIC ORTHOLOGOUS GROUPS KOGs
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EUKARIOTIC ORTHOLOGOUS GROUPS KOGs
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EUKARIOTIC ORTHOLOGOUS GROUPS KOGs
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próximamente … próximamente …
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Equipo COGEquipo COG
Eugene V. KooninEugene V. KooninSenior InvestigatorSenior InvestigatorNational Center for Biotechnology Information (NCBI)National Center for Biotechnology Information (NCBI)National Library of Medicine (NLM)National Library of Medicine (NLM)National Institutes of Health (NIH)National Institutes of Health (NIH)
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