S.K University – Department of Biotechnology, Anantapuram. Page 133
CHAPTERCHAPTERCHAPTERCHAPTER----6666
BIBILOGRAPBIBILOGRAPBIBILOGRAPBIBILOGRAP
HYHYHYHY
S.K University – Department of Biotechnology, Anantapuram. Page 134
Adelberg, E.A. and Myers, J.W. (1953). Modification of the penicillin
technique for the selection of auxotrophic bacteria, Journal of
Bacteriology, 65: 348.
Aiba, S. and Matsuoka, M. (1979). Identification of metabolic model:
Citrate production from glucose by Candida lipolytica,
Biotechnology and Bioengineering, 21: 1373-1386.
S.K University – Department of Biotechnology, Anantapuram. Page 135
Aida, K., Chibata, I., Nakayama, I., Takmami, K. and Yamada, H. (1986).
Biotechnology of amino acid production, Progress in Industrial
Microbiology, 24: 45.
Ajinomoto. (2003). Amino acid market and other information, Available
from World Wide Cited, 15: April 2005.
Ajinomoto. (2004). Feed-use amino acids business, Available from World
Wide Cited, 15: April 2005.
Akashi, S., Shibai, H. and Hirose, Y. (1979). Effect of oxygen supply on
L-lysine, L-threonine and L-isoleucine fermentations, Trends in
Biochemical Science, 43(10): 2087.
Akesson, M., Forster, J. and Nielsen, J. (2004). Integration of gene
expression data into genome scale metabolic models, Metabolic
Engineering, 6: 285-293.
Aleshin, V.V., Zakataeva, N.P. and Livshits, V.A. (1999). A new family of
amino acid efflux proteins, Trends in Biochemical Science, 24: 133-
135.
Alper, H. and Stephanopoulos, G. (2007). Global transcription
machinery engineering: a new approach for improving cellular
phenotype, Metabolic Engineering, 12: 2002-2006.
Alper, H. et al. (2005). Construction of lycopene overproducing E. Coli
strains by combining systematic and combinatorial gene-knockout
targets, Nature Biotechnology, 23: 612–616.
Alper, H. et al. (2005). Identifying gene targets for the metabolic
engineering of lycopene biosynthesis in Escherichia coli, Metabolic
Engineering, 7: 155–164.
Alper, H. et al. (2005). Tuning genetic control through promoter
engineering, Proceedings of National Academy of Sciences, U. S. A,
102: 12678–12683.
S.K University – Department of Biotechnology, Anantapuram. Page 136
Alper, H. et al. (2006). Engineering yeast transcription machinery for
improved ethanol tolerance and production, Science, 314: 1565–
1568.
Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipman, D.J.
(1990). Basic local alignment search tool, Journal of Molecular
Biology, 215: 403-410.
Altschul, S.F., Miller, W., Madden, T.L., Schaeffer, A.A., Zhang, J.,
Zhang, Z. and Lipman, D.J. (1997). Gapped BLAST and PSI-
BLAST: a new generation of protein database search programs,
Nucleic Acids Research, 25: 3389-3402.
Alvarez, I., Geli, M.I., Pimentel, E., Ludevid, D. and Torrent, M. (1998).
Lysine rich gamma zeins are secreted in transgenic Arabidopsis
plants, Planta, 205(3): 420–42.
Anastassiadis, S., Aivasidis, A. and Wandrey, C. (1999). (US5962286).
Anastassiadis, S., Aivasidis, A. and Wandrey, C. (2001). (US20016303351).
Ando, S., Ochiai, K., Yokoi, H., Hashimoto, S. and Yonetani, Y. (2002).
Novel glucose-6-phosphate dehydrogenase. (Patent WO0198472).
Araki, M., Hamatake, R.K., Johnston, L, H. and Sugino, A. (1991).
DPB2, the gene encoding DNA polymerase II subunit B, is
required for chromosome replication in Saccharomyces cerevisiae,
Proceedings of National Academy of Sciences, USA, 88: 4601-4605.
Araki, M., Sugimoto, M., Yoshihara, Y. and Nakamatsu, T. (1999).
Method for producing L-lysine. (U.S.Patent No. 6004773).
Aravind, L. and Koonin, E.V. (1999). Gleaning nontrivial structural,
functional and evolutionary information about proteins by
iterative database searches, Journal of Molecular Biology, 287:
1023–1040.
S.K University – Department of Biotechnology, Anantapuram. Page 137
Aravind, L. and Ponting, C.P. (1999). The cytoplasmic helical linker
domain of receptor histidine kinase and methyl accepting proteins
is common to many prokaryotic signalling proteins, FEMS
Microbiology Letters, 176: 111–116.
Aristidou, A. A., Bennett, G. N. and San, K.Y. (1994). Modification of the
central metabolic pathways of Escherichia coli to reduce acetate
accumulation by heterologous expression of the Bacillus subtilis
acetolactate synthase gene, Biotechnology and Bioengineering, 44:
944-951.
Aristidou, A.A. and Penttila, M. (2000). Metabolic engineering
applications for renewable resource utilization, Current Opinion in
Biotechnology, 11: 187-198.
Arutyunyan, S.Z., Karabekov, B.P. and Akopyan, E.M. (1993). A method
for producing L-lysine, (Russian Patent, SU1839680).
Asakura, Y., Usuda, Y., Tsujimoto, N., Kimura, E., Abe, C., Kawahara, Y.,
Nakamatsu, T. Kurahashi, O. (1999). (US5977331).
Bailey, J. E. (1991). Towards a science of metabolic engineering,
Science, 252: 1668-1674.
Bailey, J.E. (1999). Lessons from metabolic engineering for functional
genomics and drug discovery, Nature Biotechnology, 17: 616-618.
Bailey, J.E. et al. (1996). Inverse metabolic engineering: a strategy for
directed genetic engineering of useful phenotypes, Biotechnology
and Bioengineering, 52: 109–121.
Barret, E., Stanton, C., Zelder, O., Fitzgerald, G., and Ross, R.P. (2004).
Heterologous expression of lactose and galactose-utilizing
pathways from lactic acid bacteria in Corynebacterium glutamicum
from production of lysine in whey, Applied and Environmental
Microbiology, 70: 2861-2866.
S.K University – Department of Biotechnology, Anantapuram. Page 138
Barrett, C.L. et al. (2006). Network-level analysis of metabolic regulation
in the human red blood cell using random sampling and singular
value decomposition, BMC Bioinformatics, 13: 132.
Bathe, B., Kalinowski, J. and Puhler, A. (1996). A physical and genetic
map of the Corynebacterium glutamicum ATCC 13032
chromosomes, Journal of Molecular Genetics, 252: 255–265.
Bathe, B., Reynen, C. and Pfefferle, W. (2004). (WO04013340A2).
Batt, C.A., Folletie, M.T., Shin, H.K., Yeh, P. and Sinskey, A.J. (1985).
Genetic engineering of coryneform bacteria, Trends in
Biotechnology, 3: 305-310.
Bayer, T.S. and Smolke, C.D. (2005). Programmable ligand controlled
riboregulators of eukaryotic gene expression, Nature
Biotechnology, 23: 337–343.
Becker, J., Klopprogge, C., Herold, A., Zelder, O., Bolten, C.J., and
Wittmann, C. (2007). Metabolic flux engineering of L-lysine
production in Corynebacterium glutamicum over expression and
modification of G6P dehydrogenase. Journal of Biotechnology, 132:
99-109.
Becker, J., Klopprogge, C., Zelder, O., Heinzle, E. and Wittmann, C.
(2005). Amplified expression of fructose 1, 6-bisphosphatase in
Corynebacterium glutamicum increases in vivo flux through the
pentose phosphate pathway and lysine production on different
carbon sources, Applied Environmental Microbiology, 71: 8587–
8596.
Bellmann, A., Vrljic, M., Patek, M., Sahm, H., Kramer, R. and Eggeling,
L. (2000). Expression control and specificity of the basic amino
acid exporter LysE of Corynebacterium glutamicum, Microbiology,
147: 1765–1774.
S.K University – Department of Biotechnology, Anantapuram. Page 139
Berman, H.M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T.N.,
Weissig, H., Shindyalov, I.N. and Bourne,P.E. (2000). The Protein
Data Bank, Nucleic Acids Res, 28: 235–242.
Bertsimas, D. and Tsitsiklis, J.N. (1997). Introduction to Linear
Optimization, Athena Scientific, Belmont.
Bicciato, S., Pandin, M., Didone, G., and Di BelIo, C. (2003). Pattern
identification and classification in gene expression data using
an autoassociative neural network model. Biotecbnology
Bioengineering, 92: 227-231.
Binder, W., Dahm, F.L., Hertz, U., Friedrich, H., Lotter, H., Hohn, W., Greissinger,
D. and Polzer, W. (1997). (US5622710).
Binder, W., Friedrich, H., Lotter, H., Tanner, H., Holdrof, H. and
Leuchtenberger W. (1995). Animal feed supplement based on a
fermentation broth amino acid, a process for its production and
its use. (U.S. Patent No. 5431933).
Binder, W., Friedrich, H., Lotter, H., Tanner, H., Holldroff, H. and
Leuchtenberger, W. (1995). (US5431933).
Boles, E., Lehnert, W. and Zimmermann, F. K. (1993). The role of the
NAD- dependent dehydrogenase in restoring growth on glucose of
a Saccharomyces cerevisiae phosphoglucose isomerase mutant,
European Journal of Biochemistry, 217: 469–477.
Bonarius, H.P.J., Schmid, G. and Tramper, J. (1997). Flux analysis of
underdetermined metabolic networks: the quest for the missing
constraints, Trends in Biotechnology, 15: 308-314.
Bormann, E.R., Eikmanns, B.J. and Sahm, H. (1992). Molecular
analysis of the Corynebacterium glutamicum gdh gene encoding
glutamate dehydrogenase, Molecular Microbiology, 6: 317- 326.
S.K University – Department of Biotechnology, Anantapuram. Page 140
Borodina, I., Krabben, P. and Nielsen J. (2005). Genome-scale analysis
of Streptomyces coelicolor A3 (2) metabolism, Genome Research,
15: 820-829.
Bott, M. and Niebisch, A. (2003). The respiratory chain of
Corynebacterium glutamicum, Journal of Biotechnology, 104: 129-
153.
Bott, M., Niebisch, A., Bathe, B., Marx, A. and Hermann, T. (2002).
Method for the microbial production of polynucleotides from
coryneform bacteria and uses. (Patent No. WO0222799).
Bowie, J. U., Luethy, R. and Eisenberg, D. (1991). A method to identify
protein sequences that fold into a known three dimensional
structure, Science, 253: 164-170.
Brabetz, W., Liebl, W. and Schleifer, K.H. (1991). Studies on the utiliza-
tion of lactose by Corynebacterium glutamicum, bearing the lactose
operon of Escherichia coli, Archives of Microbiology, 155: 2213-
2218.
Bradford, M, M. (1976). A rapid and sensitive method for the
quantitation of microgram quantities of protein utilizing the
principle of protein dye binding, Annual Biochemistry, 72: 248–
254.
Brand, S., Niehaus, K., Puhler, A. and Kalinowski, J. (2003).
Identification and functional analysis of six mycolyltransferase
genes of Corynebacterium glutamicum ATCC 13032: the genes
cop1, cmt1, and cmt2 can replace each other in the synthesis of
trehalose dicorynomycolate, a component of the mycolic acid layer
of the cell envelope, Archives of Microbiology, 180: 33-44.
Bro, C., Regenberg, B., Forster, J., and Nielsen, J. (2006). In silico aided
metabolic engineering of Saccharomyces cerevisae for improved
bioethanol production, Metabolic Engineering, 8: 102-111.
S.K University – Department of Biotechnology, Anantapuram. Page 141
Broeer, S. and Kraemer, R. (1990). Lysine uptake and exchange in
Corynebacterium glutamicum, Journal of Bacteriology, 172: 7241-
7248.
Broeer, S., Eggeling, L. and Kraemer, R.(1993). Strains of
Corynebacterium glutamicum with different lysine productivities
may have different lysine excretion systems, Applied
Environmental Microbiology, 59(1): 316.
Broer, S. and Kramer, R. (1991). Lysine excreion by Corynebacterium glutamicum.
Energetics and mechanism of the transport system, European Journal of
Biochemistry, 202: 137-143.
Broquist, H. P. and Snyder, J. J. (1971). Rhizoctonia Toxin in Microbial
Toxins VII. In: S. Kadis, A. Ciegler, and S. V. Ajl (Ed.) Algal and
Fungal Toxins, Academic Press, New York, 319: 9.
Brown, G. C., Hafner, R. P. and Brand, M. D. (1990). A top down
approach to the determination of control coefficients by metabolic
control theory, European Journal of Biochemistry, 188: 321-325.
Brown, K. (2005). Biosynthesis of amino acids: highlighting synthesis
applications, Available from World Wide Cited, 15 April 2005.
Burgard, A.P. et al. (2003). OptKnock: a bilevel programming framework
for identifying gene knockout strategies for microbial strain
optimization, Biotechnology and Bioengineering, 84: 647–657.
Cameron, D. C. and Tong, I.T. (1993). Cellular and metabolic
engineering, Applied Biochemistry and Biotechnology, 38: 105-140.
Cane, D.E. (2000). Biosynthetic pathways: biosynthesis meets
bioinformatics, Science, 287: 818-819.
Cantwell, C., Beckmann, R., Whiteman, P., Queener, S.W. and
Abraham, E.P. (1992). Isolation of deacetoxy cephalosporin C from
fermentation broths of Penicillium chrysogenum: construction of a
S.K University – Department of Biotechnology, Anantapuram. Page 142
new fungal biosynthetic pathway, Proceedings of Research Society
London, 248: 283-289.
Carey, V.C., Walia, S.K. and Ingram, L.O. (1983). Expression of a lactose
transposon (Tn951) in Zymomonas mobilis, Applied Environmental
Microbiology, 46: 1163–1168.
Caspi, R., Foerster, H., Fulcher, C.A., Hopkinson, R., Ingraham, J.,
Kaipa, P., Krummenacker, M., Paley, S., Pick, J., Rhee, S.Y.,
Tissier, C., Zhang, P. and Karp, P.D. (2006). MetaCyc: a
multiorganism database of metabolic pathways and enzymes,
Nucleic Acids Research, 34: 511-516.
Chance, E. M., Seeholzer, S. H., Kobayashi, K. and Williamson, J. R.
(1983). Mathematical analysis of isotope labeling in the citric acid
cycle with applications to 13C NMR studies in perfused rat hearts,
Journal of Biological Chemistry, 258: 135-142.
Chanprateep, S., Abe, N., Shimizu, H., Yamane, T., and Shioya, S.
(2001). Multivariable control of alcohol concentrations in the
production of polyhydroxyalkanoates, PHAs, by Paracoccus
denitrans, Biotechnology Bioengineering, 74: 116-124.
Chatterjee, M., Chattedee, S.P. and Banerjee, A.K. (1990).
Producttion of L-Iysine by double auxotrophic and AEC
resistant mutants of Bacillus megaterium, Res. Ind. 35(2): 133.
Chen, N.Y., Hu, F.M. and Paulus, H. (1987). Nucleotide sequence of the
overlapping genes for the subunits of Bacillus subtilis
aspartokinase II and their control regions, Journal of Biological
Chemistry, 262: 8787–8798.
Chen, R. and Bailey, J. E. (1994). Energetic effect of Vitreoscilla
hemoglobin expression in Escherichia coli: An on Line 31P NMR
saturation transfer study, Biotechnology in Progress, 10: 360-364.
S.K University – Department of Biotechnology, Anantapuram. Page 143
Cheryl, L.P., Glick, B.R. and Pasternak. (2009). Principles and
Applications of Recombinant DNA, Washington, D.C: ASM
Press, ISBN 1-55581-498-0.
Chinard, D. (1952). Photometric estimation of proline and ornithine,
Journal of Biological Chemistry, 199: 91-95.
Cho, Y., Sharma, V. and Sacchettini, J.C. (2003). Crystal structure of
ATP phosphoribosyl transferase from Mycobacterium tuberculosis,
Journal of Biological Chemistry, 278: 8333–8339.
Choi, B.K. et al. (2003). Use of combinatorial genetic libraries to
humanize N-linked glycosylation in the yeast Pichia pastoris,
Proceedings of National Academy of Sciences, U. S. A, 100: 5022–
5027.
Christensen, B. (2001). Metabolic Network Analysis: Principles,
Methodologies and Applications. PhD-Thesis: BioCentrum-DTU,
Technical University of Denmark, Lyngby.
Christensen, B. and Nielsen, J. (1999) b. Isotopomer analysis using GC-
MS, Metabolic Engineering, 1: 282-290.
Christensen, B. and Nielsen, J. (1999) b. Metabolic network analysis,
Advances in Biochemical Engineering, 66: 209-231.
Christensen, B. and Nielsen, J. (2000). Metabolic network analysis of
Penicillum chrysogenum using 13C-labelled glucose, Biotechnology
and Bioengineering, 68: 652-659.
Christensen, B. et al. (2002). Analysis of flux estimates based on 13 C
labelling experiments, European Journal of Biochemistry, 269:
2795–2800.
Clark, R., Doherty, P.D. and Tolnarjr, E.J. (1987). (US4684190).
Cocaign Bousquet, M. and Lindley, N.D. (1995). Pyruvate overflow and
carbon flux within the central metabolic pathways of
S.K University – Department of Biotechnology, Anantapuram. Page 144
Corynebacterium glutamicum during growth on lactate, Enzyme
and Microbial Technology, 17: 260-267.
Cocaign-Bousquet, M., Guyonvarch, A. and Lindley, N.D. (1996). Growth
rate dependent modulation of carbon flux through central
metabolism and the kinetic consequences for glucose limited
chemostat cultures of Corynebacterium glutamicum, Applied and
Environmental Microbiology, 62: 429-436.
Coello, N., Brito, L. and Nonus, M. (2000). Biosynthesis of L-lysine by
Corynebacterium glutamicum grown on fish silage, Bioresource
Technology, 73: 221–225.
Coello, N., Pan, J.G. and Lebeault, J.M. (1992). Physiological aspects of
L-lysine production: effect of nutritional limitations on a
producing strain of Corynebacterium glutamicum, Applied
Microbiology and Biotechnology, 38(2): 259-260.
Cohen, G.N., Patte, J.C. and Truffa Bachi. (1965). Parallel
modifications caused by mutations in two enzymes concerned
with the biosynthesis of threonine in Escherichia coli,
Biochemistry and Biophysics Research Communication, 19(4): 546.
Colby, D.W. et al. (2004). Potent inhibition of huntingtin and cytotoxicity
by a disulfide bond free single domain intracellular antibody,
Proceedings of National Academy of Sciences, U. S. A, 101: 17616–
17621.
Collins, M.D, Goodfellow, M. and Minnikin, D.E. (1982)b. Fatty acid
composition of some mycolic acid containing coryneform bacteria,
Journal of General Microbiology, 128: 2503-2509.
Colon, G.E., Nguyen, T.T., Jetten, M, S, M., Sinskey, A.J. and
Stephanopoulos, G. (1995). Production of isoleucine by
overexpression of ilvA in a Corynebacterium lactofermentum
threonine producer, Applied Microbiology and Biotechnology, 43:
482-488.
S.K University – Department of Biotechnology, Anantapuram. Page 145
Correia, A., Martin, J.F. and Castro, J.M. (1994). Pulsed field gel
electrophoresis analysis of the genome of amino acid producing
corynebacteria: chromosome sizes and diversity of restriction
patterns, Microbiology, 140: 2841-2847.
Correia, A., Pisabarro, A., Castro, J.M. and Martin, J.F. (1996). Cloning
and characterization of an IS-like element present in the genome
of Brevibacterium lactofermentum ATCC 13869, Gene, 170: 91-94.
Cortassa, S., Aon, J. C. Aon, M. A. (1995). Fluxes of carbon,
phosphorylation, and redox intermediates during growth of
Saccharomyces cerevisiae on different carbon sources,
Biotechnology and Bioengineering, 47: 193–208.
Covert, M.W. and Palsson, B.O. (2003). Constraints based models:
regulation of gene expression reduces the steady state solution
space, Journal of Theoretical Biology, 221: 309-325.
Covert, M.W., Knight, E.M., Reed, J.L., Herrgard, M.J. and Palsson B.O.
(2004). Integrated high throughput and computational data
elucidates bacterial networks, Nature, 429: 92-96.
Covert, M.W., Schilling, C.H., and Palsson, B.O. (2001) b. Regulation of
gene expression in flux balance models of metabolism, Journal of
Theoretical Biology, 213: 73-88.
Covert, M.W., Schilling, C.H., Famili, I., Edwards, J.S., Goryanin, I.I.,
Selkov, E. and Palsson, B.O. (2001) a. Metabolic modeling of
microbial strains in silico, Trends in Biochemical Science, 26: 179-
186.
Cremer, J., Eggeling, L. and Sahm, H. (1990). Cloning the dapA dapB
cluster of the lysine-secreting bacterium Corynebacterium
glutamicum, Molecular Genetics and Genomics (Historical Archive),
220: 478-480.
S.K University – Department of Biotechnology, Anantapuram. Page 146
Cremer, J., Eggeling, L. and Sahm, H. (1991). Control of the lysine
biosynthesis sequence in Corynebacterium glutamicum as analysed
by overexpression of the individual corresponding genes, Applied
and Environmental Microbiology, 57: 1746-1752.
Crociani, F., Selli, A., Criseting, G., Giosa, D. and Matteuzzi, D. (1991).
L-lysine production at 65 degree by auxotrophic regulatory
mutants of Bacillus stearothermophilis, Journal of Indian
Microbiology, 8: 127-132.
Da Silva, N.A. and Bailey, J.E. (1991). Influence of dilution rate and
induction of cloned gene expression in continuous fermentations
of recombinant yeast, Biotechnology and Bioengineering, 37: 309–
317.
Daffe M. (2005). The Cell Envelope of Corynebacteria, In: Eggeling L,
Bott M, editors. Handbook of Corynebacterium glutamicum, Boca
Raton: CRC Press. P 121-148.
Dagley, S., Dawes, E. A. and Morrison, G. A. (1950). Factors influencing
the early phases of growth of Aerobacter aerogenes, Journal of
General Microbiology, 4: 437-447.
Davis, B.D. (1952). Biosynthesis interrelations of time and aeration
intensity on the L-lysine, diamnopimelic acid and threonine in
mutants production in a continuous culture in Escherichia coli,
Nature, 169: 533-534.
Davis, B.D. and Mingioli, E.S. (1950). Mutants of Escherichia coli,
requiring methionine or vitamin B12, Journal of Bacteriology, 60:
17.
De Graaf A.A. (2000). Metabolic flux analysis of Corynebacterium
glutamicum. In: Schugerl K, Bellgard KH, editors. Bioreaction
Engineering: modelling and control. Berlin: Springer Verlag. P
506-555.
S.K University – Department of Biotechnology, Anantapuram. Page 147
De Graaf, A.A., Eggeling, L. and Sahm, H. (2001). Metabolic engineering
for L-lysine production by Corynebacterium glutamicum, Advances
in Biochemical Engineering and Biotechnology, 73: 9–29.
Demain, A.L. and Adrio J.L. (2008) .Contributions of microorganisms to
industrial biology, Molecular Biotechnology, 38: 41-55.
Dewey, D.L. and Work, E. (1952). Diaminopimelic acid and lysine,
Nature, 169: 533-538.
Diaz Ricci, J. C., Tsu, M. and Bailey, J. E. (1992). Influence of
expression of the pet operon on intracellular metabolic fluxes of
Escherichia coli, Biotechnology and Bioengineering, 39: 59–65.
Dominguez, H., Rollin, C., Guyonvarch, A., Guerquin-Kern, J.L.,
Cocaign Bousquet, M. and Lindley, N.D. (1998). Carbon flux
distribution in the central metabolic pathways of Corynebacterium
glutamicum during growth on fructose, European Journal of
Biochemistry, 254: 96-102.
Drechsel, E. (1890).Studies on the formation of urea from protein,
Berichte, 23: 3096.
Dulaney, E.L. (1957). Formation of extracellular lysine by UstiIago
maydis, Journal of Microbiology, 3: 467.
Dulaney, E.L., Bilinski, E. and McConnell, W.B. (1956).
Extracellular organic nitrogen in Ustilago maydis fermentation
broths, Journal of Biochemistry and Physiology, 34: 1195.
Dunican, L.K., Mc Cormack, A., Stapelton, C., Burke, K., O'Donohue,
M., Marx, A., and Mockel, B. (2001). Cloning and uses of a novel
nucleotide sequence coding for a glucose-6-phosphate isomerase
(pgi) from bacteria. European Patent [EP 1087015].
Edelman, J.C. and Gilvarg, C. (1961). Isotope studies on diaminopimelic
acid synthesis in E. coli, Journal of Biological Chemistry, 236:
3295-3298.
S.K University – Department of Biotechnology, Anantapuram. Page 148
Edwards, J.S. and Palsson, B.O. (2000). The Escherichia coli MG1655 in
silico metabolic genotype: Its definition, characteristics, and
capabilities, PNAS, 97: 5528-5533.
Edwards, J.S., Ibarra, R.U. and Palsson B.O. (2001). In silico predictions
of Escherichia coli metabolic capabilities are consistent with
experimental data, Nature Biotechnology, 19: 125-130.
Eggeling, L., Cremer, J. and Sahm, H. (1991). Control of the Lysine
biosynthesis sequence in Corynebacterium glutamicum as analyzed
by over expression of the individual corresponding genes, Applied
and environmental microbiology, 57(6): 1746-1752.
Eggeling, L., Oberle, S. and Sahm, H. (1998). Improved L-lysine yield
with Corynebacterium glutamicum: use of dapA resulting in
increased flux combined with growth limitation, Applied
Microbiology and Biotechnology, 49: 24-30.
Eikmanns, B., Metz, M., Reinscheid, D., Kricher, M. and Sahm, H.
(1991). Amplification of three threonine biosynthetic genes in
Corynebacterium glutamicum and its influence on carbon flux in
different strains, Applied Microbiology and Biotechnolgy, 34: 617.
Eikmanns, B.J. (1992). Identification, sequence analysis, and expression
of a Corynebacterium glutamicum cluster encoding the three
glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase,
3-phosphoglycerate kinase, and triosephosphate isomerase,
Journal of Bacteriology, 174: 6076-6086.
Eikmanns, B.J., Blombach, B., Schreiner, M.E., Moch, M. and Oldiges,
M. (2007). Effect of pyruvate dehydrogenase complex deficiency on
L-lysine production with Corynebacterium glutamicum, Applied
Microbiology and Biotechnology, 76(3): 615-23.
Eikmanns, B.J., Eggehng, L. and Sahm, H. (1993). Molecular aspects of
lysine, threonine, and isoleucine biosynthesis in Corynebacterium
glutamicum, Antonie van Leeuwenhoek, 64: 145-163.
S.K University – Department of Biotechnology, Anantapuram. Page 149
Eikmanns, B.J., Follettie, M.T., Griot, M.U. and Sinskey, A.J. (1989).
The phosphoenolpyruvate carboxylase gene of Corynebacterium
glutamicum: molecular cloning, nucleotide sequence and
expression, Molecular Genome and Genetics, 218: 330-339.
Eikmanns, B.J., Kircher, M. and Reinscheid, D.J. (1991). Dis-
crimination of Corynebacterium glutamicum, Brevibacterium flavum
and Brevibacterium lactofermentum by restriction pattern analysis
of DNA adjacent to the horn gene, FEMS Microbiology Letters, 82:
203-208.
Eikmanns, B.J., Rittmann, D. and Sahm, H. (1995). Cloning, sequence
analysis, expression, and inactivation of the Corynebacterium
glutamicum icd gene encoding isocitrate dehydrogenase and
biochemical characterization of the enzyme, Journal of
Bacteriology, 177: 774-782.
Endo, I. and Inoue, I. (1976). Metabolic activities of yeast cells in the
batch culture. Kagaku Kogaku Ronbunshu, 2: 416-42 1.
Erdmann, A., Weil, B. and Kraemer, R. (1993). Regulation of lysine
excretion in the lysine producer strain Corynebacterium
glutamicum MH 20-22B, Biotechnology Letters, 17: 927-932.
Faehnle, C.R., Liu, X., Pavlovsky, A. and Viola, R.E. (2006). The initial
step in the archaeal aspartate biosynthetic pathway catalyzed by a
monofunctional aspartokinase, Applied Biochemistry and
Biotechnology, 62: 962–966.
Falco, S.C., Guida, T., Locke, M., Mauvais, J., Sanders, C., Ward, R.T.
and Webber, P. (1995). Transgenic canola and soyabean seeds
with increased lysine, Nature Biotechnology, 13: 577-582.
Famili, I. et al. (2003). Saccharomyces cerevisiae phenotypes can be
predicted by using constraint based analysis of a genome-scale
reconstructed metabolic network, Proceedings of National
Academic Sciences, U. S. A., 100: 13134–13139.
S.K University – Department of Biotechnology, Anantapuram. Page 150
Fechter, W. L., Dienst, J. H. and Le Patourel, J. F. (1997). (US5684190).
Feist, A.M., Scholten, J.C.M., Palsson, B.O., Brockman, F.J., and Ideker,
T. (2006). Modelling methanogenesis with a genome scale
metabolic reconstruction of Methanosarcina barkeri, Molecular
Systems Biology, 2: 1-14.
Fell, D.A. (1992). Metabolic control analysis: a survey of its theoretical
and experimental development, Biochemistry Journal, 286: 313-
330.
Fell, D.A. and Sauro, M. (1985). Metabolic control and its analysis,
European Journal of Biochemistry, 148: 555-561.
Ferreira, C. and Durate, I, C. (1991). Glucose utilization by lysine
producing fluroacetate sensitive mutants of Corynebacterium
glutamicum, Applied Biochemistry and Biotechnology, 27: 251-257.
Fischer, E. and Sauer, U. (2005). Large-scale in vivo flux analysis shows
rigidity and suboptimal performance of Bacillus subtilis
metabolism, Nature Genetics, 37: 636–640.
Fischer. E. and Weigert, F. (1902). Synthesis of Dicaprionic acid
for lysine production. The metabolic roles, pharmacology, and
toxicology of lysine, Journal of Microbiology, 16(1): 7-21.
Follettie, M.T., Peoples, O.P., Agoropoulou, C. and Sinskey, A.J. (1993).
Gene structure and expression of the Corynebacterium flavum N13
ask-asd operon, Journal of Bacteriology, 175: 4096-4103.
Follettie, M.T., Shin, H.K. and Sinskey, A.J. (1988). Organization and
regulation of the Corynebacterium glutamicum horn-thr B and thr
C loci, Molecular Microbiology, 2: 53-62.
Forberg, C., Eliaeson, T., and Haggstrom, L. (1988). Correlation of
theoretical and experimental yields of phenylalanine from non-
growing cells of a rec Escherichia coli strain, Journal of
Biotechnology, 7: 319-332.
S.K University – Department of Biotechnology, Anantapuram. Page 151
Forster, J., Famili, I., Fu, P., Palsson, B.O. and Nielsen, J. (2003).
Genome scale reconstruction of the Saccharomyces cerevisiae
metabolic network, Genome Research, 13: 244-253.
Friesner, R.A.B., Murphy, J.L., Halgren, R.B., Klicic, T.A., Mainz, J.J.,
Repasky, D.T., Knoll, M.P., Shelley, E.H., Perry, M., Shaw, J.K.,
Francis, D.E., Shenkin, P. and Glide, P.S. (2004). A new approach
for rapid, accurate docking and scoring method and assessment of
docking accuracy, Journal of Medicinal Chemistry, 47:1739–1749.
Fung, E. et al. (2005). A synthetic gene-metabolic oscillator, Nature,
435: 118–122.
Gaillardin, C.M., Poirier, L., Ribet, A.M. and Ileslot, H. (1979).
General and lysine specific control of Saccharopine
dehydrogenase levels in the yeast Saccharotnycopsis lipolytica,
Biochimie, 61(4): 473.
Gallagher, D.T., Gilliland, G.L., Xiao, G., Zondlo, J., Fisher, K.E.,
Chinchilla, D. and Eisenstein, E. (1998). Structure and control of
pyridoxal phosphate dependent allosteric threonine deaminase,
Structure, Biotechnology and Bioengineering, 6: 465–475.
Garnier, J., Osguthorpe, D.J and Robson, B. (1978). Analysis and
implications of simple methods for predicting the secondary
structure of globular proteins, Journal of Molecular Biology, 120:
97-120.
Georgi, T., Rittmann, D., and Wendisch, V.F. (2005). Lysine and
glutamate production by Corynebacterium glutamicum on glucose,
fructose and sucrose: Roles of malic enzyme and fructose-1, 6-
bisphosphatase, Metabolic Engineering, 7: 291-301.
Gerstmeier, R., Wendisch, V.F., Schnicke, S., Ruan, H., Farwic, M.,
Reinscheid, D. and Eikmanns, B.J. (2003). Acetate metabolism
and the regulation in Corynebacterium glutamicum, Journal of
Biotechnology, 104: 99-122.
S.K University – Department of Biotechnology, Anantapuram. Page 152
Gilvarg C. (1957). N-succinyl-L-diaminopimelic acid, an intermediate in
the biosynthesis of diaminopimelic acid, Biochemistry and
Biophysics Acta, 24: 216-217.
Gilvarg C. (1961). N-Succinyl-α-amino-ε-ketopimelic acid, Journal of
Biological Chemistry, 236: 1429-1431.
Gilvarg, C. (1956). Biosynthesis of diaminopimelic acid, Federation
Proceedings, 15: 261-262.
Gilvarg, C. (1962). The branching point in Diaminopimelic acid
synthesis, Journal of Biological Chemistry, 237: 482-487.
Glanemann, C., Loos, A., Gorret, N., Willis, L.B., Obrien, X.M., Lessard,
P.A. and Sinskey, A.J. (2003). Disparity between changes in mRNA
abundance and enzyme activity in Corynebacterium glutamicum:
implications for DNA microarray analysis, Applied Microbiology
and Biotechnology, 61: 61–68.
Gourdon, P., Baucher, M.F., Lindley, N.D., and Guyonvarch, A. (2000).
Cloning of the malic enzyme gene from Corynebacterium
glutamicum and role of the enzyme in lactate metabolism, Applied
and Environmental Microbiology, 66: 2981-2987.
Grace, H.L., Won, H., Craig, E.B. and Michael, C.F. (1996). Lysine
production from methanol at 50°C using Bacillus methanolicus
modeling volume control lysine concentration and productivity
using a three phase continuous simulation, Biotechnology and
Bioengineering, 49: 639-653.
Griffith, R.S., Norins, A.L. and Kagan, C. (1978). A multicentered study
of lysine therapy in Herpes simplex infection, Dermatologica,
156(5): 257-67.
Gubler, M., Jetten, M., Lee, S. H. and Sinskey, A. J. (1994)b. Cloning of
the pyruvate kinase gene (pyk) of Corynebacterium glutamicum
and site specific inactivation of pyk in a lysine producing
S.K University – Department of Biotechnology, Anantapuram. Page 153
Corynebacterium lactofermentum strain, Applied Microbiology and
Biotechnology, 60: 2494–2500.
Gubler, M.E., Park, S.M., Jetten, M.S., and Stephanopoulos, G. (1994).
Effects of phosphoenolpyruvate carboxylase deficiency on
metabolism and lysine production in Corynebacterium glutamicum,
Applied Microbiology and Biotechnology, 40: 857-863.
Guido, N.J. et al. (2006). A bottom up approach to gene regulation,
Nature, 439: 856–860.
Guillout, S., Rodal, A.A, Lessard, P.A. and Sinskey, A.J. (2002). Methods
for producing L-isoleucine, USA patent [US 6451564 B1].
Hadj Sassi, A., Fauvart, L., Deschamps, A.M. and Lebeault, J.M.
(1988). Fed batch production of L-lysine by Corynebacterium
glutamicum, Biochemical Engineering Journal, 1: 85-90.
Hagino, H., Kobayashi, S., Araki, K. and Nakayama, K. (1981). L-lysine
production by mutant of Bacillus lichinoformis, Biotechnology
Letters, 3: 425-430.
Hanke, P.D., Li-D Elia, L.Y., Walsh, H.J., Crafton, C.M. and Rayapati, P.J. (2005).
(US20056927046).
Hartmann, M., Tauch, A., Eggeling, L., Bathe, B., Mockel, B., Puhler, A.
and Kalinowski, J. (2003). Identification and characterization of
the last two unknown genes, dapC and dapF in the succinylase
branch of the L-lysine biosynthesis of Corynebacterium
glutamicum, Journal of Biotechnology, 104: 199–211.
Hatzimanikatis, V., Floudas, C. and Bailey, J. E. (1996). Analysis and
design of metabolic reaction networks via mixed integer linear
optimization, Journal of Biotechnology, 42: 1277-1292.
Hayakawa, A., Sugimoto, M., Yoshihara, Y. and Nakamatsu, T. (2001).
(US20016221636).
S.K University – Department of Biotechnology, Anantapuram. Page 154
Hayashi, M., Mizogushi, H., Shiraishi, N., Obayashi, M., Nakagawa, S.,
Imai, J., Watanabe, S., Ota, T. and Ikeda, M. (2002).
Transcriptome analysis of acetate metabolism in Corynebacterium
glutamicum using a newly developed metabolic array, Biosciences
Biotechnology and Biochemistry, 66: 1337–1344.
Heinemann, M., Kummel, A., Ruinatscha, R. and Panke, S. (2005). In
silico genome scale reconstruction and validation of the
Staphylococcus aureus metabolic network, Biotechnology and
Bioengineering, 92: 850-864.
Heinrich, R. and Rapoport, T. A. (1974). A linear steady state treatment
of enzymatic chains. General properties, control and effector
strength, European Journal of Biochemistry, 42: 39-95.
Heinzle, E., Biwer, A. and Cooney, C.L. (2001). Development of sustainable
bioprocesses modeling and assessment, Wiley, Chichester, pp 155–168.
Hermann T. (2003). Industrial production of amino acids by coryneform
bacteria, Journal of Biotechnology, 104:155–172.
Hermann, M., Thevenet, N.J., Coudert Maralier, M.M. and
Vandecasteele, J.P. (1972). Consequences of lysine
oversynthesis in pseudomonas mutants insensitive to feedback
inhibition. Lysine exceretion or endogenous induction of a
lysine catabolic pathway, European Journal of Biochemistry,
30(1): 100.
Hermann, S., Lothar, E., Bernd, E. and Reinhard, K. (1995). Metabolic
design in amino acid producing bacterium Corynebacterium
glutamicum, FEMS Microbiology Reviews, 16: 243-252.
Hermann, T., Finkemeier, M., Pfefferle, W., Wersch, G., Kramer, R. and
Burkovski, (2000). A Two dimensional electrophoretic analysis of
Corynebacterium glutamicum membrane fraction and surface
proteins, Electrophoresis, 21: 654–659.
S.K University – Department of Biotechnology, Anantapuram. Page 155
Hermann, T., Pfefferle, W., Baumann, C., Busker, E., Schaffe, R S., Bott,
M., Sahm, H., Dusch, N., Kalinowski, J., Puhler, A., Bendt, A.K.,
Kramer, R. and Burkovski, A. (2001). Proteome analysis of
Corynebacterium glutamicum, Electrophoresis, 22: 1712–1723.
Hermann, T., Wersch, G., Uhlemann, E.M., Schmid, R. and Burkovski
A. (1998). Mapping and identification of Corynebacterium
glutamicum proteins by two dimensional gel electrophoresis and
micro sequencing, Electrophoresis, 19: 3217–3221.
Hermann, T., Wolf, A., Morbach, S. and Kramer, R. (2002). Nucleotide
sequences coding for the OtsA protein, U.S. Patent Application No.
(US2002192674).
Herrgard, M.J., Fong, S.S. and Palsson, B.O. (2006). Identification of
Genome-scale metabolic network models using experimentally
measured flux profiles, PLoS Computationel Biology, 2: 676- 686.
Hillger, M., Gross, H.H., Menz, Bormann, E.J., Grosse, P.,
Miosga, N., Kreibich, G. and Fuchs, R. (1991). Optimization
of lysine manufacture by fermentation, Middle East Journal of
Scientific Research, DD 2 115:112-118.
Hilliger, M. and Hanel, F. (1981). Process analysis of L-lysine
fermentation under different oxygen supply, Biotechnology Letters,
3: 219-224.
Hilliger, M. and Prauser, H. (1989). L-lysine formation in the
corynebacterium glutamicum, Journal of Microbiology, 34: 427-428.
Hilliger, M., Fuchs, R., Kreibich, G., Menz, J., Weise, Harzfeld,
G. and Boettcher, J. (1990). Lysine fermentation using
molasses as carbon source, Middle East Journal of Scientific
Research, DD. 281: 451.
S.K University – Department of Biotechnology, Anantapuram. Page 156
Hilliger, M., Haenel, F. and Menz, J. (1984). Influence of temperature on
growth and L. lysine formation in Corynebacterium glutamicum,
Journal of Applied Microbiology, 24: 437-441.
Hirao, T. and Nakano, T. (1991). Amino acid fermentation,
Biotechnology and bioengineering Chem Abs. 114:141-161
Hirao, T., Nakano, T., Azuma, T., Sugimoto, M. and Nakanishi, T.
(1989). L-lysine production in continuous culture of an L-lysine
hyperproducing mutant of Corynebacteriutn glutamicum, Applied
Microbiology and Biotechnology, 32(3): 269.
Hirose, Y. and Shibai, H. (1985). L-Glutamic acid fermentation,
Comprehensive biotechnology, 3: 595–600.
Hoare, D.S. and Work, E. (1957). The Stereoisomers of α ε
diaminopimelic acid, their distribution in the bacterial order
Actinomycetales and in certain Eubacteriales, Biochemistry
Journal, 65: 441.
Hoek, J. B. and Rydstro m, J. (1988). Physiological roles of nicotinamide
nucleotide transhydrogenase, Biochemistry Journal, 254: 1–10.
Hoischen, C. and Kramer, R. (1990). Membrane alteration is necessary
but not sufficient for effective glutamate secretion in
Corynebacterium glutamicum, Journal of Bacteriology, 172: 3409-
3416.
Hollander, J.A. (1994). Potential metabolic limitations in lysine
production by Corynebacterium glutamiucm as revealed by
metabolic network analysis, Applied Microbiology and
Biotechnology, 42: 508-515.
Hua, Q., Yang, C. and Shimizu, K. (2000). Metabolic control analysis for
lysine synthesis using Corynebacterium glutamicum and
experimental verification, Journal of Bioscience and
Bioengineering, 90: 184-192.
S.K University – Department of Biotechnology, Anantapuram. Page 157
Huang, J., Shimizu, H. and Shioya, S. (2002). Data preprocessing and
output evaluation of autoassociative neural network for online
fault detection in virginiamycin production. Journal of Bioscience
and Bioengineering, 94: 7-77.
Hundley, J.M. and Ing, R.B. (1956). Algae as sources of lysine and
threonine in supplementing wheat and bread diets, Science.
124: 536.
Ibarra, R.U. et al. (2002). Escherichia coli K-12 undergoes adaptive
evolution to achieve in silico-predicted optimal growth, Nature
420: 186–189.
Ikeda, M. and Katsumata, R. (1992). Metabolic Engineering to produce
tyrosine or phenylalanine in a tryptophan producing
Corynebacterium glutamicum strain, Applied and Environmental
Microbiology, 58: 781–785.
Ikeda, M. and Katsumata, R. (1999). Hyperproduction of tryptophan by
Corynebacterium glutamicum with the modified pentose phosphate
pathway, Applied and Environmental Microbiology, 65: 2497–2502.
Ikeda, M. and Nakagawa, S. (2003). The Corynebacterium glutamicum
genome: Features and impacts on biotechnological processes,
Applied Microbiology and Biotechnology, 62: 99–109.
Ikeda, M., Ohnishi, J. and Mitsuhashi, S. (2005). L-lysine
fermentation by aminoethylcysteine resistant Corynebacterium
glutamicum mutants, Applied and Environmental Microbiology, 52:
413-419.
Ikeda, M., Ohnishi, J., Hayashi, M. and Mitsuhashi, S. (2006). A genome
based approach to create a minimally mutated Corynebacterium
glutamicum strain for efficient L-lysine production, Journal of
Indian Microbiology and Biotechnology, 33: 610–615.
S.K University – Department of Biotechnology, Anantapuram. Page 158
Ingraham, J.L., Maaloe, O. and Niedhardt, F.C. (1983). Growth of the
Bacterial Cell, Sunderland, Massachusetts: Sinauer Associates,
Inc. 435 p.
Inui, M., Murakami, S., Okino, S., Kawaguchi, H., Vertes, A.A. and
Yukawa H. (2004). Metabolic analysis of Corynebacterium
glutamicum during lactate and succinate productions under
oxygen deprivation conditions, Journal of Molecular Microbiology
and Biotechnology, 7: 182–196.
Inuzuka, K. and Hamada, S. (1976). (US3959075).
Ishii, T., Yokomori, M. and Miwa, H. (1997). (US5650304).
Ishino, S., Mizukami, T., Yamaguchi, K., Katsumata, R. and Araki, K.
(1988). Cloning and sequencing of the meso-diaminopimelate-o-
dehydrogenase (ddh) gene of Corynebacterium glutamicum,
Agricultural Biology and Chemistry, 52: 2903-2909.
Ishino, S., Mizukami, Z., Yamaguchi, K., Katsumata, R. and Araki, K.
(1987). Nucleotide sequence of the meso-diaminopimelate D-
dehydrogenase gene from Corynebacterium glutamicum, Nucleic
Acids Research, 15: 3917.
Israilides, C. J., Weir, A.N. and Bull, A.T. (1989). Effect of antibiotic
on lysine production in free and immobilized cells of Bacillus
subtilis, Applied Microbiology and Biotechnology, 32: 134-136.
Jang, K.H., Pierotti, D., Kemp, G.W., Best, G.R. and Britz, M.L. (1997).
Mycolic acid composition of Corynebacterium glutamicum and its
cell surface mutants: effects of growth with gycine and isonicotinic
acid hydrazide, Microbiology UK, 143: 3209-3221.
Jeffries, T.W. and Jin, Y.S. (2004). Metabolic engineering for improved
fermentation of pentoses by yeasts, Applied Microbiology and
Biotechnology, 63: 495–509.
S.K University – Department of Biotechnology, Anantapuram. Page 159
Jens, N. and Henrik, S.J. (1995). Metabolic control analysis of the
penicillin biosynthetic pathway in a high yielding strain of
Penicillium chrysogenum, Biotechnology in Progress, 11(3): 299-
305.
Jetten, M.S. and Sinskey, A.J. (1995). Purification and properties of oxaloacetate
decarboxylase from Corynebacterium glutamicum, Antonie Van
Leeuwenhoek, 67: 221-227.
Jetten, M.S., Gubler, M. E., Mc Cormick, M. M., Colon, G. E., Follettie,
M. T. and Sinskey, A.J. (1993). Industrial Micro-organisms, Basic
Applied Molecular Genetics, Vol. 13
Jetten, M.S.M. and Sinskey, A.J. (1995). Purification and properties of
oxaloacetate decarboxylase from Corynebacterium glutamicum,
Antonie van Leeuwenhoek, 67: 221-227.
Jing-Xiu Bi, J.S. and Al-Rubeai, M. (2004). Uncoupling of cell growth
and proliferation results in enhancement of productivity in
p21CIP1 arrested CHO cells, Biotechnology and Bioengineering,
85: 741–749.
Jorgenen, H.S., Nielsen, J., Villadsen, J., and Mollgaard, H. (1995).
Metabolic flux distributions in Penicillium chrysogenum during fed
batch cultivations, Biotechnology and Bioengineering, 46: 117-
131.
Kalcheva, H.O., Shanskaya, V., Smutny, O. and Maluta, S.S. (1991).
Effect of dimethyl sulfoxide on lysine production by mutant
of Bacillus subtilis with low homoserine dehydrogenase activity,
Folia Microbiology, 36: 447-450.
Kalinowski, J., Bachmann, B., Thierbach, G. and Puhler, A. (1990).
Aspartokinase genes 1ysCa and 1ysC8 overlap and are adjacent to
the aspartate l3-semialdehyde dehydrogenase gene asd in
Corynebacterium glutamicum, Molecular General Genetics, 224:
317-324.
S.K University – Department of Biotechnology, Anantapuram. Page 160
Kalinowski, J., Bathe, B., Bartels, D., Bischoff, N., Bott, M., Burkovski,
A., Dusch, N., Eggeling, L., Eikmanns, B.J. and Gaigalat, L.
(2003). The complete Corynebacterium glutamicum ATCC 13032
genome sequence and its impact on the production of aspartate
derived amino acids and vitamins, Journal of Biotechnology, 104:
5-25.
Kalinowski, J., Bathe, B., Bartels, D., Bischoff, N., Bott, M., Burkovski, A., Dusch,
N., Eggeling, L., Eikmanns, B.J., Gaigala,t L., Goesmann, A., Hartmann,
M., Huthmacher, K., Kramer, R., Linke. B., McHardy, A.C., Meyer, F.,
Mockel, B., Pfefferle, W., Puhler, A., Rey, D.A., Ruckert, C., Rupp, O.,
Sahm, H., Wendisch, V.F., Wiegrabe, I. and Tauch, A. (2003). The
complete Corynebacterium glutamicum ATCC 13032 genome sequence
and its impact on the production of l-aspartate derived amino acids and
vitamins, Journal of Biotechnology, 104: 5–25.
Kalinowski, J., Cremer, J., Bachmann, B., Eggeling, L., Sahm, H. and Puhler, A.
(1991). Genetic and biochemical analysis of the aspartokinase from
Corynebacterium glutamicum, Molecular Microbiology, 5:1197–1204.
Kamimura, R. T., Bicciato, S., Shimizu, H., Alford, J. and
Stephanopoulos, G. (2000). Mining of biological data I:
identification of discriminating features via mean hypothesis
testing, Metabolic Engineeing, 2:218-227.
Kanehisa, M., Goto, S., Hattori, M., Kinoshita, K.F., Itoh, M.,
Kawashima, S., Katayama, T., Araki, M. and Hirakawa, M. (2006).
From genomics to chemical genomics: new developments in
KEGG, Nucleic Acids Research, 34: 354-357.
Kaneko, T. and Co Workers. (1974). Synthetic production and
utilization of amino acids, New York, 3rd edition, vol. 2, p.
376 .
S.K University – Department of Biotechnology, Anantapuram. Page 161
Kao, C.M.F. (1997). Structure, Function and Engineering of Modular
Polyketide Synthases. Ph.D. Thesis, Department of Chemical
Engineering, Stanford University.
Kaplun, A., Vyazmensky, M., Zherdev, Y., Belenky, I. and Slutzker, A.
(2006). Structure of the regulatory subunit of acetohydroxy acid
synthase isozyme III from Escherichia coli, Journal of Molecular
Biology, 357: 951–963.
Karp, P.D., Ouzounis, C.A., Moore Kochlacs, C., Goldovsky, L., Kaipa,
P., Ahren, D., Tsoka, S., Darzentas, N., Kunin, V. and Bigas, N.
(2005). Expansion of the BioCyc collection of pathway genome
databases to 160 genomes, Nucleic Acids Research, 33: 6083-
6089.
Kase, H. and Nakayama, K. (1970). Production of alpha
diaminopimelic acid by lysine auxotrophs of various bacteria,
Chem. Abs, 74:396.
Kase, H. and Nakayama, K. (1974). Studies on L-threonine fermentation,
mechanism of L-threonine and L-lysine production by analog-
resistant mutants of Corynebacterium glutamicum, Agricultural
and Bioloigcal Chemistry, 38: 993-1000.
Kato, C., Kurihara, T., Kobashi, N., Yamane, H, and Nishiyama, M.
(2004). Conversion of feedback regulation in aspartate kinase
by domain exchange, Biochemistry Biophysics Research
Communications, 316: 802–808.
Katsumata, R., Ozaki, A., Mizukami, T., Kageyama, M., Yagisawa, M., Mizukami,
T., Itoh, S., Oka, T. and Furuya, A. (1993). (US5236831).
Kawaguchi, H., Sasaki, M., Vertes, A.A., Inui, M., and Yukawa, H.
(2008). Engineering of an L-arabinose metabolic pathway in
Corynebacterium glutamicum, Applied Microbiology and
Biotechnology, 77: 1053-1062.
S.K University – Department of Biotechnology, Anantapuram. Page 162
Kawaguchi, H., Vertes, A.A., Okino, S., Inui, M., and Yukawa, H. (2006).
Engineering of a xylose metabolic pathway in Corynebacterium
glutamicum, Applied and Environmental Microbiology, 72: 3418-
3428.
Kawahara, Y., Yoshihara, Y., Ikeda, M. and Yoshii H. (1990). Effect of
glycine betaine, an osmoprotective compound, on the growth
of Brevibacterium lactofermentum, Applied Microbiology and
Biotechnology, 33: 574-577.
Kawahara, Y., Yoshihara, Y., Ikeda, M., Yoshii, H. and Hirose, Y. (1990).
Stimulatory effect of glycine betaine on L-lysine fermentation, Applied
Microbiology and Biotechnology, 34: 87-90.
Keddie, R.M. and Cure, G.L. (1978). Cell wall Compsition of Coryneform
Bacteria. In: Bousfield IJ, Calley AG, editors. Coryneform Bacteria.
London: Academic Press. p 47-84.
Kelle, R., Hermann, T. and Bathe, B. (2005). L-lysine production. In
Handbook of Corynebacterium glutamicum (Edited by Eggeling, L.
and Bott, M.) pp. 465-488. CRC Press, Boca Raton.
Kelleher, J. K., Bryan, B. M., Mallet, R. I., Holleran, A. L., Murphy, A. N.
and Fiskum, G. (1987). Analysis of tricarboxylic acid-cycle
metabolism of hepatoma cells by comparison of 14CO2 ratios,
Biochemistry Journal, 246: 633-639.
Kelleher, J.K. (2001). Flux estimation using isotopic tracers: common
ground for metabolic physiology and metabolic engineering,
Metabolic Engineering, 3(2): 100-110.
Kelley, B.P. et al. (2004). PathBLAST: A tool for alignment of protein
interaction networks, Nucleic Acids Research, 32: 1183–1188.
Kellogg, S. T., Chatterjee, D. K. and Chakrabarty, A. M. (1981). Plasmid
assisted molecular breeding: new technique for enhanced
S.K University – Department of Biotechnology, Anantapuram. Page 163
biodegradation of persistent toxic chemicals, Science, 214: 1133-
1135.
Khosla, C. and Bailey, J. E. (1988). Heterologous Expression of Bacterial
Hemoglobin Improves the Growth Properties of Recombinant
Escherichia coli, Nature, 331: 633-635.
Kiefer, P., Heinzle, E. and Wittmann, C. (2002). Influence of glucose, fructose and
sucrose as carbon sources on kinetics and stoichiometry of lysine
production by Corynebacterium glutamicum, Journal of Indian Microbiology
and Biotechnology, 28: 338–343.
Kiefer, P., Heinzle, E., Zelder, O. and Wittmann, C. (2004). Comparative
metabolic flux analysis of lysine producing Corynebacterium
glutamicum cultured on glucose or fructose, Applied and
Environmental Microbiology, 70: 229-239.
Kikuchi, Y., Nakanishi, K. and Kojima, H. (1999). (US5932453).
Kikuchi, Y., Suzuki, T. and Kojima, H. (1996). Production of lysine by
culture of transformant E. coli, Japanese Patent (W09617930).
Kim, B.H., Seong, B.L., Mheen, T.I. and Han, M.H. (1981). Studies on
microbial penicillin amidase, optimization of the enzyme
production from Escherichia coli, Korean Journal of Applied
Microbiology and Bioengineering, 9(1): 29.
Kim, H.M., Heinzle, E. and Wittmann, C. (2006). Deregulation of aspartokinase
by single nucleotide exchange leads to global flux rearrangement in the
central metabolism of Corynebacterium glutamicum, Journal of
Microbiology and Biotechnology, 8: 1174-1179.
Kim, S.J. (1994). New micro-organism producing L-lysine patent, Korean
Patent (KR9401307).
Kim, S.J., Seong, B.L., Mheen, T.I. and Han, M.H. (1981). Studies
on microbial penicillin anildase. I. Optimization of the enzyme
S.K University – Department of Biotechnology, Anantapuram. Page 164
production from Escherichia coli, Korean Journal of Applied
Microbiology and Bioengineering, 9(1): 29.
Kimura, E. (2003). Metabolic engineering of glutamate production, vol
79: Springer, Berlin Heidelberg New York, pp 37–57.
Kimura, E., Abe, C., Kawahara, Y., Yoshihara, Y. and Nakamatsu, T. (1999).
(US5929221).
Kimura, E., Asakura, Y., Uehara, A., Inoue, S., Kawahara, Y., Yoshihara, Y. and
Nakamatsu, T. (1998). (US5846790).
Kimura, E., Eggeling, L. and Bott, M. (Eds.). (2005). Handbook of
Corynebacterium glutamicum, CRC Press, Taylor & Francis, Boca
Raton, FL, USA, 439–463.
Kinoshita S, Udaka, S. and Shimono, M. (1990). Studies on the amino
acid fermentation, production of L-glutamic acid by various
microorganisms, Journal of General and Applied Microbiology, 2:
165–175.
Kinoshita, S. (1987). Amino acid and nucleotide fermentations: From
their genesis to the current state, Developments in Industrial
Microbiology, 28:1-12.
Kinoshita, S. and Nakayatna, K. (1978). Amino acids. In
Economic Microbiology, vol. 2, Primary products of
metabolism. Ed. Rose, A.H. Academic Press, London, P. 209.
Kinoshita, S., Nakayama, K. and Akita, S. (1958). Taxonomical study
of glutamic acid accumulating bacteria, Micrococcus gluiamicus,
Agriculture and Chemistry Society Japan, 22(3): 176.
Kinoshita, S., Nakayama, K. and Kitada, S. (1961). Method of producing L-lysine
by fermentation, US Patent. (2979439).
Kinoshita, S., Shigezo, U. and Shimono, M. (1957). Studies on the amino acid
fermentation, Part I. Production of L-glutamic acid by various
S.K University – Department of Biotechnology, Anantapuram. Page 165
microorganisms, Journal of General of Applied and Microbiology, 3:193–
205.
Kinoshita, S., Udaka, S. and Shimono, M. (1959). The production of
amino acids by fermentation processes, In advances in
Applied Microbiology. vol. 1 Academic Press, New York, p.
201.
Kinoshita, S., Ukada, S. and Shimono, M. (1957). Studies on the amino
acid fermentation, Journal of General and Applied Microbiology, 9:
19–25.
Kiss, R.D. and Stephanopoulos, G. (1991). Metabolic activity control of
the L-lysine fermentation by restrained growth fed-batch
strategies, Biotechnology in Progress, 7: 501–509.
Kiss, R.D. and Stephanopoulos, G. (1992). Metabolic characterization of a
L-lysine-producing strain by continuous culture, Biotechnology and
Bioengineering, 39: 565–574.
Kitada, S., Nakayama, K. and Kinoshita, S. (1961). US Patent.
(2979439).
Kiyoshi, N. and Hiroshi, H. (1971). (US3595751).
Kiyoshi, N., Haruo, T. and Hiroshi, H. (1972). (US3700557).
Klapa, M. et al. (1999). Metabolite and isotopomer balancing in the
analysis of metabolic cycles, Biotechnology and Bioengineering,
62: 375–391.
Klapa, M. I., Park, S. M., Sinskey, A. J., and Stephanopoulos, G. (1998).
Effect of the tricarboxylic acid cycle on metabolite labeling. I.
Theory, Journal of Bioscience and Bioengineering, 42: 456-459.
Knoll, A., Buchs, J. (2006). L-lysine coupling of bioreaction and process model,
Journal of Metabolic Engineering, 76: 976.
S.K University – Department of Biotechnology, Anantapuram. Page 166
Kobashi, N., Nishiyama, M. and Tanokura, M. (1999). Kinetic and
mutation analyses of aspartate kinase from Thermus flavus,
Journal of Bioscience and Bioengineering, 87: 739–745.
Koffas, M. and Stephanopoulos, G. (2005). Strain improvement by
metabolic engineering: lysine production as a case study for
systems biology, Current Opinion in Biotechnology, 16: 361–366.
Koffas, M.A.G., Jung, G.Y., and Stephanopoulos, G. (2003). Engineering
metabolism and product formation in Corynebacterium
glutamicum by coordinated gene overexpression, Metabolic
Engineering, 5: 32-41.
Koffas, M.A.G., Jung, G.Y., Aon, J.C. and Stephanopoulos, G. (2002).
Effect of pyruvate carboxylase overexpression on the physiology of
Corynebacterium glutamicum, Applied and Environmental
Microbiology, 68: 5422-5428.
Koffas, M.A.G., Jung, G.Y., Aon, J.C. and Stephanopoulos, G. (2002).
Effect of pyruvate carboxylase overexpression on the physiology of
Corynebacterium glutamicum, Applied and Environmental
Microbiology, 68: 5422-5428.
Komura, I., Yamada, K. and Otsuka, S. (1975). Taxonomic significance of
phospholipids in coryneform and nocardioform bacteria, Journal of
General and Applied Microbiology, 21: 251.
Konicek, J., Smekal, F. and Radochova, M.K. (1991). Effect of tween 80
and dimethyl sulfoxide on biosynthesis of L-lysine in regulatory
mutants of Corynebacterium glutamicum, Folia Microbiology, 36:
587-589.
Kost, T.A. et al. (2005). Baculovirus as versatile vectors for protein
expression in insect and mammalian cells, Nature Biotechnology,
23: 567–575.
S.K University – Department of Biotechnology, Anantapuram. Page 167
Kotaka, M., Ren, J., Lockyer, M., Hawkins, A.R. and Stammers, D.K.
(2006). Structures of R and T state Escherichia coli aspartokinase
III, mechanisms of the allosteric transition and inhibition by
lysine, Journal of Biological Chemistry, 281: 31544–31552.
Kramer, B.P. and Fussenegger, M. (2005). Hysteresis in a synthetic
mammalian gene network, Proceedings of National Academy of
Sciences, U. S. A, 102: 9517–9522.
Kramer, B.P. et al. (2004). An engineered epigenetic transgene switch in
mammalian cells, Nature Biotechnology, 22: 867–870.
Kramer, J.O., Sorgenfrei, O., Klopprogge, K., Heinzle, E. and Wittmann,
C. (2004). In depth profiling of lysine producing Corynebacterium
glutamicum by combined analysis of the transcriptome,
metabolome, and fluxome, Journal of Bacteriology, 186(6): 1769–
1784.
Kreutzer, C., Hans, S., Osnabruck, R.M., Mockel, B., Pfeffere, W., Eggeling, L.,
Sahm, H. and Patek, M. (2001). (US20016200785).
Kreutzer, C., Hans, S., Rieping, M., Mockel, B., Pfefferle, W., Eggeling, L., Sahm,
H. and Patek, M. (2004). (US20046746855).
Kreutzer, C., Hans, S., Rieping, M., Mockel, B., Pfefferle, W., Eggeling, L., Sahm,
H. and Patek, M. (2006). (US20067094584).
Kreutzer, C., Mockel, B., Pfefferle W., Eggeling, L., Sahm, H. and Patek, M. (2006).
(ES2247987T).
Kreutzer, C., Mockel, B., Pfefferle, W., Eggeling, L., Sahm, H. and Patek, M.
(2005). (US20056861246).
Kreutzer, M.T., Du, P., Heiszwolf, J.J., Kapteijn, F. and Moulijn, J.A.
(2001).Mass transfer characteristics of three phase monolith
reactors,Chemical Engineering Science, 56: 6015–6023.
S.K University – Department of Biotechnology, Anantapuram. Page 168
Kroger, M., Wahl, R., Schachtel, G. and Rice, P. (1992). Compilation of
DNA sequences of Escherichia coli, Nucleic Acids Research,
(Suppl.) 20: 2119-2144.
Kromer, J.O, Sorgenfrei, O., Klopprogge, K., Heinzle, E. and Wittmann,
C. (2004). In-depth profiling of lysine producing Corynebacterium
glutamicum by combined analysis of the transcriptome,
metabolome, and fluxome, Journal of bacteriology, 186:1769-
1784.
Kromer, J.O., Wittmann, C., Schroder, H. and Heinzle, E. (2006). Metabolic
pathway analysis for rational design of L-methionine production by
Escherichia coli and Corynebacterium glutamicum, Metabolic Engineering,
8: 353–369.
Kubota, K., Maeyashiki, I., Shiro, T., Noborn, K.S. and Kamagawa, K.
(1970). Method of producing L-lysine, United States Patent No.
(3527672).
Kubota, K., Maeyashiki, I., Shiro, T., Noborn, K.S. and Kamagawa, K.
(1999). The influence of carbon and nitrogen sources and metal ions on
the growth of Ustilago maydis on lysine and threonine production,
Biotechnology and Bioengineering, 4: 37.
Kumagai, H. (2000). Microbial production of amino acids in Japan,
Advaces in Biochemical Engineering and Biotechnology, 69: 71–85.
Kumar, V., Ramakrishnan, S., Teeri, T. T., Knowles, J. K. C. and Hartey,
B.S. (1992). Saccharomyces cerevisiae cells secreting an
Aspergilus niger galactosidase grown on whey permeate,
Biotechnology, 10: 82-85.
Kurz, W.G. and Ericson. L.E. (1962). Microbiological production of amino acids,
Journal of Industrial Microbiology, 70: 345-349
Kuyper, M. et al. (2004). Minimal metabolic engineering of
Saccharomyces cerevisiae for efficient anaerobic xylose
S.K University – Department of Biotechnology, Anantapuram. Page 169
fermentation: a proof of principle, FEMS Yeast Research, 4: 655–
664.
Ladner, W., Pressler, U. and Siegel, W. (1998). (US5770412).
Laksmann, M, Shenoy, B.C. and Rao, M.R.R. (1981). Aspartokinase of a
lysine producing mutant of Micrococcus glutamicus, Journal of
Bioscience, 3: 57-61.
Lange, C., Rittmann, D., Wendisch, V.F., Bott, M. and Sahm, H. (2003).
Global expression profiling and physiological characterization of
Corynebacterium glutamicum grown in the presence of L-valine,
Applied and Environmental Microbiology, 69: 2521–2532.
Larson, R.L., Sandine, W.D. and Broquist, H.P. (1963). Enzymic
reduction of α-aminoadipic acid: Relation to lysine biosynthesis,
Journal of Biological Chemistry, 238: 275-279.
Laskowski, R.A., Mac Arthur, M.W., Moss, D.S. and Thornton, J.M.
(1993). PROCHECK: a program to check the stereochemical
quality of protein structures, Journal of Applied Crystallography,
26: 283–291.
Leaf, T.A. and Srienc, F. (1998). Metabolic modeling of polyhydroxy
butyrate biosynthesis, Biotechnology and Bioengineering, 57: 557-
570.
Lee, J. W., Tevault, C. V., Blankinship, S. L., Collins, R. T. and
Greenbaum, E. (1994). Photosynthetic water splitting: In situ
photoprecipitation of metallocatalysts for photoevolution of
hydrogen and oxygen, Energy Fuels: ACS Journal, 8: 770-773.
Lee, J.Y., Roh, J.R. and Kim, H.S. (1994). Metabolic engineering of
Pseudomonas putida for the simultaneous biodegradation of
benzene, toluene, and p-xylene mixture, Biotechnology and
Bioengineering, 43: 1146-1152.
S.K University – Department of Biotechnology, Anantapuram. Page 170
Leonard, E. et al. (2006). Functional expression of a P450 flavonoid
hydroxylase for the biosynthesis of plant specific hydroxylated
flavonods in Escherichia coli, Metabolic Engineeering, 8: 172–181.
Leuchtenberger, W. (1996). Amino acids technical production and use in
biotechnology, Journal of Biotechnology, 101: 66–502.
Leuchtenberger, W. (1996). Amino acids technical production and use,
Rehm HJ, Reed G (eds) Biotechnology, VCH, Weinheim Vol 6: p
465.
Leuchtenberger, W., Huthmacher, K. and Drauz, K. (2005).
Biotechnological production of amino acids and derivate: current
status and prospects, Applied Microbiology and Biotechnology,
69:1–8.
Li, H. et al. (2006). Optimization of humanized IgGs in glyco engineered
Pichia pastoris, Nature Biotechnology, 24: 210–215.
Liao, J. C. and Delgado, J. (1993). Advances in metabolic control
analysis, Biotechnology in Progress, 9: 221-233.
Liaw, H.J., Eddington, J., Yang, Y., Dancey, R., Swisher, S. and Mao, W. (2006).
(US20066984512).
Liaw, H.J., Eddington, J., Yang, Y., Dancey, R., Swisher, S. and Mao, W. (2006)
(US20067122369).
Liebl, W. (2005). Corynebacterium taxonomy. In Handbook of
Corynebacterium glutamicum, CRC, Boca Raton, 9–34.
Liebl, W. and Tzvetkov, M.V. (2008). Phytate utilization by genetically
engineered lysine producing Corynebacterium glutamicum, Journal
of Biotechnology, 134: 211-217.
Liebl, W., Ehrmann, M., Ludwig, W. and Schleifer, K.H. (1991). Transfer
of Brevibacterium divaricatum DSM 20297T, ‘Brevibacterium
Jiavum’ DSM 20411, ‘Brevibacterium lactofermentum’ DSM 20412
S.K University – Department of Biotechnology, Anantapuram. Page 171
and DSM 1412, and Corynebacterium iilium DSM 20137T to
Corynebacterium glutamicum and their distinction by rRNA gene
restriction patterns, Internet Journal of Systematic Bacteriology,
41: 255-260.
Liu, Y.T. and Wu, W.T. (1994). Stirred tank bioreactor with a
recirculation loop for improved L-lysine production, Biotechnology
Techniques, 8: 67-70.
Loos, A., Glanemann, C., Willis, L.B., Obrien, X.M., Lessard, P.A.,
Gerstmeier, R., Guillouet, S. and Sinskey, A.J. (2001).
Development and validation of Corynebacterium DNA microarrays,
Applied and Environmental Microbiology, 67: 2310-2318.
Lu, J.H. and Liao, C.C. (1997). Site-directed mutagenesis of the
aspartikinase gene lysC and its characterization in Brevibacterium
flavum, Letters in Applied Microbiology, 24: 211-213.
Luthy, R., Bowie, J.U. and Eisenberg, D. (1992). Assessment of protein
models with three dimensional profiles, Nature, 356: 83-85.
Mac Quitty, J. J. (1988). Impact of Biotechnology on the Chemical
Industry, ACS Symposium, 362: 11-29.
Maerz, U., (2005). World markets for fermentation ingredients. Available
from World Wide Cited, 15 April 2005.
Majander, K. et al. (2005). Extracellular secretion of polypeptides using
a modified Escherichia coli flagellar secretion apparatus, Nature
Biotechnology, 23: 475–481.
Malloy, C. R., Sherry, A. D. and Jeffrey, F. M. H. (1988). Evaluation of
carbon flux and substrate selection through alternate pathways
involving the citric acid cycle of the heart by 13C NMR
spectroscopy, Journal of Biological Chemistry, 263: 6964-6971.
S.K University – Department of Biotechnology, Anantapuram. Page 172
Malloy, C. R., Sherry, A. D., and Jeffrey, F. M. H. (1987). Carbon flux
through citric acid cycle pathways in perfused heart by 13C NMR
spectroscopy, FEBS Letters, 212: 58-62.
Malloy, C. R., Sherry, A. D., and Jeffrey, F. M. H. (1990). Analysis of the
tricarboxylic acid cycle of the heart using 13C isotope isomers,
American Journal of Physiology, 259: 987-995.
Malmberg, L.H. and Hu, W.S. (1992). Identification of rate limiting steps
in cephalosporin C biosynthesis in Cephalosporium acremonium: a
theoretical analysis, Applied Microbiology and Biotechnology, 38:
122-128.
Malumbres, M., Gil, J.A and Martin, J.F. (1993). Codon preference in
Corynebacteria, Gene, 134: 15-24.
Malumbres, M., Mateos, L.M. and Martin, J.F. (1995). Microorganisms
for amino acid production: Escherichia coli and corynebacteria. In:
Food Biotechnology: Microorganisms (Hui, Y.H. and
Khachatourians, G.G., Eds.), Vol. 2, pp. 423469. VCH Publishers,
New York.
Malumbres, M., Mateos, L.M., Lumbreras, M.A., Guerrero, C. and
Martin, J.F. (1994). Analysis and expression of the thrC gene of
Brevibacterium lactofermentum and characterization of the
encoded threonine synthase, Applied and Environmental Micro
biology, 60: 2209-2219.
Malumbres, M., Mateos, L.M., Martin, J.F., Hui, Y.H. and
Khachatourians, G.G, (1996). Food biotechnology microorganisms,
VCH Verlagsgesellschaft, Weinheim, p 423.
Manallack, D. T., Pitt, W. R., Gancia, E., Montana, J. G., Livingstone, D.
J. and Ford, M. G. (2002). Selecting screening candidates for
kinase and G protein-coupled receptor targets using neural
networks, Journal of Chemical and Computational Science, 42(5):
1256-1262.
S.K University – Department of Biotechnology, Anantapuram. Page 173
Mancuso, A., Sharfstein, S. T., Tucker, S. N., Clark, D. S. and Blanch.
(1994). Examination of primary metabolic pathways in a murine
hybridoma with carbon-13 NMR spectroscopy, Biotechnology and
Bioengineering, 44: 563-585.
Marco Mar, C., Ramon, S., Maiques, S. and Tavares, V.R. (2003). Site
directed mutagenesis of Escherichia coli acetyl glutamate kinase
and aspartate kinase III probes the catalytic site and substrate
binding mechanisms of these amino acid kinase family enzymes
and allows three-dimensional modelling of aspartate kinase,
Journal of Molecular Biology, 334: 459–476.
Martin, J.F. (1989). Molecular genetics of amino acid producing
corynebacteria. In: Microbial Products. New Approaches
(Baumberg, S., Hunter, I. and Rhodes, M., Eds.), pp. 25-59,
Society for General Microbiology Symposium, 44: Cambridge
University Press, Cambridge.
Martin, J.F., Santamaria, R., Sandoval, H., Del Real, G., Mateos, L.M.,
Gil, J.A. and Aguilar, A. (1987). Cloning systems in amino acid
producing corynebacteria, BioTechnology, 5: 137-146.
Martin, R. V., Jacob, R. M., Yantosca, Chin, M. and Ginoux P. (2002).
Global and regional decreases in tropospheric oxidants from
photochemical effects of aerosols, Journal of Geophysics Research,
108(D3): 4097.
Martin, V.J.J. et al. (2003). Engineering a mevalonate pathway in
Escherichia coli for production of terpenoids, Nature Biotechnology,
21: 796–802.
Marx, A., De Graaf, A.A., Wiechert, W., Eggeling, L. and Sahm, H.
(1996). Determination of the fluxes in the central metabolism of
Corynebacterium glutamicum by nuclear magnetic resonance
spectroscopy combined with metabolite balancing, Biotechnology
and Bioengineering, 49: 111-129.
S.K University – Department of Biotechnology, Anantapuram. Page 174
Marx, A., de Graaf, A.A., Wiechert, W., Eggeling, L. and Sahm, H. (1996).
Determination of the fluxes in the central metabolism of
Corynebacterium glutamicum by nuclear magnetic resonance
spectroscopy combined with metabolite balancing, Biotechnology
and Bioengineering, 49: 111-129.
Marx, A., Eikmanns, B.J., Sahm, H., de Graaf, A.A. and Eggeling L.
(1999). Response of the central metabolism in Corynebacterium
glutamicum to the use of an NADH-dependent glutamate
dehydrogenase, Metabolic Engineering, 1: 35-48.
Marx, A., Eikmanns, B.J., Sahm, H., De Graaf, A.A. and Eggeling, L.
(1999). Response of the central metabolism in Corynebacterium
glutamicum to the use of an NADH-dependent glutamate
dehydrogenase, Metabolic Engineering, 1: 35-48.
Marx, A., Hans, S., Mockel, B., Bathe, B., and De Graaf, A.A. (2003).
Metabolic phenotype of phosphoglucose isomerase mutants of
Corynebacterium glutamicum, Journal of Biotechnology, 104: 185-
197.
Marx, A., Striegel, K., de Graaf, A.A., Sahm, H. and Eggeling L. (1997).
Response of the central metabolism of Corynebacterium
glutamicum to different flux burdens, Biotechnology and
Bioengineering, 56:168-180.
Mas Droux, C., Curien, G., Robert Genthon, M., Laurencin, M., Ferrer,
J.L. and Dumas, R. (2006). A novel organization of ACT domains
in allosteric enzymes revealed by the crystal structure of
Arabidopsis aspartate kinase, Plant Cell, 18:1681–1692.
Massaoudi, E.M., Spelthahn, J., Drysch, A., De Graaf, A.A. and Takors,
R. (2003). Production process monitoring by serial mapping of
microbial carbon flux distributions using a novel sensor reactor
approach: I Sensor reactor system, Metabolic Engineering, 5: 86-
95.
S.K University – Department of Biotechnology, Anantapuram. Page 175
Mateos, L.M., Del Real, G., Aguilar, A. and Martin, J.F. (1987). Cloning
and expression in Escherichia coli of the homo serine kinase (thrB)
gene from Brevibacterium lactofermentum, Molecular and General
Genetics, 206: 361-367.
Mateos, L.M., Mateos, L.M., Pisabarro, A., Patek, M., Malumbres, M.,
Guerrero, C., Eikmanns, B.J., Sahm, H. and Martin, J.F. (1994).
Transcriptional analysis and regulatory signals of the horn-thr B
cluster of Brevibacterium lactofermentum, Journal of Bacteriology,
176: 7362-7371.
Mattoon, J.R. and Haight, R.D. (1962). Glutamic acid accumulation by a
lysine-requiring yeast mutant, Journal of Biological Chemistry
237: 3484-3486.
May, O., Nguyen, P. and Arnold, F. (2000). Inverting enantioselectivity
by directed evolution of hydantoinase for improved production of
L-methionine, Nature Biotechnology, 18: 317–320.
May, O., Verseck, S., Bommarius, A. and Drauz, K. (2002). Development
of dynamic kinetic resolution processes for biocatalytic production
of natural and non natural L-amino acids, Organic Process
Research and Devepelopment, 6:452-457.
McGinnis, S. and Madden, T.L. (2004). BLAST: at the core of a powerful
and diverse set of sequence analysis tools, Nucleic Acids Research,
32: 20-25.
Meadow, P. and Work E. (1959). Biosynthesis of DAP and lysine in
E. coli, Incorporation of C14 DAP, lysine and Glucose, Biochemistry
Journal, 72: 400-403.
Meadow, P.D., Hoare, S. and Work, E. (1957). Inter relationships
between lysine and α, ε- DAP, their derivatives and analogues in
mutant of E. coli, Biochemistry Journal, 66: 270-274.
S.K University – Department of Biotechnology, Anantapuram. Page 176
Menkel, E., Thierbach, G., Eggeling, L. and Sahm, H. (1989). Influence
of aspartate availability on lysine formation by a recombinant
strain of Corynebacterium glutamicum and utilization of fumarate,
Applied and Environmental Microbiology, 55: 684-688.
Mitchell, H.K. and Houlahan, M.B. (1948). An intermediate in the
biosynthesis of lysine in Neurospora, Journal of Biological
Chemistry, 174: 883-887.
Miwa, K., Terabe, M., Ishida, M., Matsui, H. and Momose, H. (1985).
(US4560054)
Miwa, K., Terabe, M., Ishida, M., Matsui, H. and Momose, H. (1985).
(US4560654).
Miyajima, R. and Shiio, L. (1971). Regulation of aspartate family amino
acid biosynthesis in Brevibacterium flavum and repression of the
enzymes in threonine biosynthesis, Journal of Biochemistry, 35:
424-430.
Miyajima, R., Otsuka, S.I. and Shiio, I. (1969). Regulation of aspartate
family amino acid biosynthesis in Brevibacterium flavum, Journal
of Biochemistry, 63: 139-148.
Mockel, B., Pfefferle, W., Kreutzer, C., Hans, S., Rieping, M., Eggeling, L.
and Sahm, H. (1999). EU Patent Application EP1067192.
Mockel, B., Weibenborn, A., Pfefferle, W., Puhler, A., Kalinowski, J.,
Bathe, B. and Dusch N. (2001). Nucleotide sequence encoding
Corynebacterium poxb-gene and its use in the preparation of
L-lysine, E.U. Patent Application No. EP1096013.
Mockel, B., Weissenborn, A., Pfefferle, W., Kalinowski, J., Bathe, B. and
Puhler, A. (1999). Genome sequencing of industrial
microorganisms: the Corynebacterium glutamicum ATCC 13032
genome project, Microbes and Computational Genomics, 4: 111.
S.K University – Department of Biotechnology, Anantapuram. Page 177
Moir, D. and Paulus, H. (1977). Properties and subunit structure of
aspartokinase II from Bacillus subtilis VB217, Journal of Biological
Chemistry, 252: 4648-4654
Mori, M., Shiio, I. (1985). Purification and some properties of
phosphoenol pyruvate carboxylase from Brevibacterium flavum
and its over producing mutant, Journal of Biochemistry, 97: 1119–
1128.
Moritz, B., Striegel, K., De Graaf, A.A. and Sahm, H. (2000). Kinetic
properties of the glucose-6-phosphate and 6-phosphogluconate
dehydrogenases from Corynebacterium glutamicum and their
application for predicting pentose phosphate pathway flux in vivo,
Eurupeon Journal of Biochemistry, 267: 3442–3452.
Moritz, B., Striegel, K., De Graff, A.A. and Sahm, H. (2000). Kinetic
properties of the glucose-6-phosphate and 6-phosphogluconate
dehydrogenases from Corynebacterium glutamicum and their
application for predicting pentose phosphate pathway flux in vivo,
European Journal of Biochemistry, 267:3442-3452.
Moriya, M., Matsui, H., Yokozeki, K., Hirano, S., Hayakawa, A., Izui, M. and
Sugimoto, M. (1998). (US5804414).
Moszezyensky, P., Golabezak, J., Nyk, G. and Ziminska, M. (1991).
Microbiological synthesis of lysine using free and immobilized cells
of Corynebacterium glutamicum, Przen Fermentation, 35: 3-13.
Muffler, A., Bettermann, S., Haushalter, M., Horlein, A., Neveling, U.,
Schramm, M. and Sorgenfrei, O. (2002). Genome wide
transcription profiling of Corynebacterium glutamicum after heat
shock and during growth on acetate and glucose, Journal of
Biotechnology, 98: 255-268.
Murakami, Y., Miwa, H. and Nakamori, S. (1993). (US5250423).
S.K University – Department of Biotechnology, Anantapuram. Page 178
Muralidhara, D.R, Abdul Razak, M., Praveena, B. and Swamy, A.V.N.
(2007). Dissolved Oxygen concentration analysis of L-lysine
fermentation production by Corynebacterium glutamicum, The
Internet Journal of Pharmacology, 6: 11-17.
Nakagawa, S., Mizoguchi, H., Ando, S., Hayashi, M., Ochiai, K., Yokoi,
H., Tateishi, N., Senoh, A., Ikeda, M. and Ozaki A. (2003). Novel
polynucleotides, European patent, (11082001790).
Nakamura, T., Nakayama, T., Koyama, Y., Shimazaki, K., Miwa, H., Tsuruta, M.,
Tamura, K. and Tosaka, O. (2000). (US20006025169).
Nakanishi, T., Azuma, T., Hirao, T., Hattori, K. and Sakurai, M. (1986).
(US4623623).
Nakayama, H.V and Araki, K. (1973). Process for producing L-lysine, US
patent (3708395).
Nakayama, K. (1972). Lysine and diaminopimelic acid in the microbial
production of amino acids, Kodansha Int, Tokyo, Journal of
General and Applied Microbiology, 93: 372-380.
Nakayama, K., Araki, K. and Tanaka, Y. (1979). (US469763).
Nakayama, K., Kinoshita, S. (1961). Studies on lysine fermentation, α, ε-
diaminopimelic acid accumulation and diaminopimelic acid
decarboxylase, Journal of General and Applied Microbiology, 7(3):
161.
Nakayama, K., Kitada, S. and Kinoshita, S. (1961). Studies on lysine
fermentation, α, ε-diaminopimelic acid and its decarboxylase in
lysine producing strain and parent strain, Journal of General and
Applied Microbiology, 7(3):145.
Nakayama, K.J.A. and Araki, K.J.A. (1973). (US3708395).
Nakazawa, H., Yamane, I. and Akutsu, E. (1982). (US4334020).
S.K University – Department of Biotechnology, Anantapuram. Page 179
Nakazawa, M., Takahashi, D., Onishi, N., Naito, M., Izawa, K. and Yokozeki, K.
(2006). (US20067012152).
Nampoothiri, K. M., Hoischen, C., Bathe, B., Mockel, B., Pfefferle, W.,
Krumbach, K., Sahm, II. and Eggeling, L. (2002). Expression of
genes of lipid synthesis and altered lipid com- position modulates
L-glutamate efflux of Corynebacterium glutamicum, Applied
Microbiology and Biotechnology, 58: 89-96.
Nasri, M., Dhouib, A., Zorguani, F., Kriaa, H. and Ellouz, R. (1989).
Production of lysine by using immobilized living Corynebacterium
sp. Cells, Biotechnology Letters, 11(2): 865.
Nawrath, C., Poirier, Y. and and Somerville, C. (1994). Targeting of the
polyhydroxybutyrate biosynthetic pathway to the plastids of
Arabidopsis thaliana results in high levels of polymer
accumulation, Proceedings of National Academy of Sciences, USA,
91: 12760.
Neidhardt, F. C., Ingraham, J. L. and Schaechter, M. (1990). Physiology
of the Bacterial Cell, Sinauer Associates, Inc., Sunderland, MA.
Neish, A.C. (1952). Analytical methods for bacterial fermentation,
Manual, published by the National Research Council of Canada.
P.I.
Nerem, R. M. (1991). Cellular engineering, Annual Biomedical
Engineering, 19: 529-545.
Netzer, R., Krause, M., Rittmann, D., Peters-Wendisch, P., Eggeling, I.,
Wendisch, V.F., and Sahm,H. (2004). Roles of pyruvate kinase and
malic enzyme in Corynebacterium glutamicum for growth on
carbon source requiring gluconeogenesis, Archives of Microbiology,
182: 354-363.
S.K University – Department of Biotechnology, Anantapuram. Page 180
Nissen, T. L., Schulze, U., Nielsen, J. and Villadsen, J. (1997). Flux
distributions in anaerobic, glucose limited continuous cultures of
S. cerevisiae, Microbiology, 143: 203-218.
Nomura, Y., Iwahara, M. and Hongo, M. (1987). Application of dialysis
culture to L-lysine fermentation, Agricultural and Chemical Society
Japan, 61: 957-962.
Nyberg, G. (1998). Protein quality in mammalian cell culture, Ph.D.
Thesis, Massachusetts Institute of Technology.
Nyberg, G., Balcarcel, R., Follstad, B., Stephanopoulos, G. and Wang, D.
I. C. (1997). Glycosylation site occupancy in continuous culture of
Chinese Hamster Ovary cells producing recombinant human
gamma interferon, AIChE Annual meeting, Los Angeles, Paper
229b.
O’Regan, M., Thierbach, G., Bachmann, B., Villeval, D., Lepage, P.,
Viret, J.F. and Lemoine, Y. (1989). Cloning and nucleotide
sequence of the phosphoenolpyruvate carboxylase coding gene of
Corynebacterium glutamicum, Gene, 77: 237-251.
Oguiza, J.A., Malumbres, M., Eriani, G., Pisabarro, A., Ma- teos, L.M.,
Martin, F. and Martin, J.F. (1993). A gene encoding arginyl-tRNA
synthetase is located in the upstream region of the IysA gene in
Brevibacterium lactofermentum: Regulation of argS-IysA cluster
expression by arginine, Journal of Bacteriology, 175: 7356-7362.
Oh, J. W., Kim, S.J., Cho, Y.J., Park, N. H. and Lee, J.H. (1993). (US5268293).
Ohnishi, J., Hayashi, M., Mitsuhashi, S. and Ikeda, M. (2003). Efficient
40°C fermentation by a new Corynebacterium glutamicum mutant
developed by genome breeding, Applied Microbiology and
Biotechnology, 62: 69-75.
Ohnishi, J., Hayashi, M., Mitsuhashi, S., and Ikeda, M. (2003). Efficient
40°C fermentation of L-lysine by a new Corynebacterium
S.K University – Department of Biotechnology, Anantapuram. Page 181
glutamicum mutant developed by genome breeding, Applied
Microbiology and Biotechnology, 62: 69-75.
Ohnishi, J., Kakahira, R., Mitsuhashi, S., Kakita, S., and Ikeda, M.
(2005). A novel gnd mutation leading to increased L-lysine
production in Corynebacterium glutamicum, FEMS Microbiology
Letters, 242: 265-274.
Ohnishi, J., Mitsuhashi, S., Hayashi, M., Ando, S., Yokoi, H., and Ikeda,
M. (2002). A novel methology employing Corynebacterium
glutamicum genome information to generate a new L-lysine
producing mutant, Applied Microbiology and Biotechnology, 58:
217-223.
Ohta, K., Beall, D. S., Mejia, J. P., Shanmugam, K. T. and Ingram, L. O.
(1991) a. Genetic improvement of Escherichia coli for ethanol
production: Chromosomal integration of Zymomonas mobilis genes
encoding pyruvate decarboxylase and alcohol dehydrogenase II,
Applied and Environmental Microbiology, 57: 893-900.
Okumura, S., Okada, H., Nosaki, S., Yoshinaga, F., Hirakawa, H., Kamijo, H.,
Kubota, K. and Yoshihara, Y. (1974) (US3825472).
Oliveira, A.P, Nielsen, J. and Forster, J. (2005). Modelling Lactococcus
lactis using a genome-scale flux model, BMC Microbiology, 5:39.
Ong, S.E. and Mann, M. (2005). Mass spectrometry based proteomics
turns quantitative, Nature Chemical Biology, 1: 252–262.
Overchenko, M.B., Rimareva, L.V, Trifonova, V.V and Igonatova N.I.
(1996). Use of vegetable juice in the biosynthesis of lysine using
Brevibacterium sp., PriklBiokhim Mikrobiol, 32: 448-452.
Ozaki, A., Katsumata, R., Oka, T. and Furuya, A. (1985). Cloning of
the genes concerned in phenylalanine biosynthesis in
Corynebacterium glutamicum and its application to breeding of a
S.K University – Department of Biotechnology, Anantapuram. Page 182
phenylalanine producing strain, Agricultural and Biological
Chemistry, 49: 2925-2930.
Pae, K.M., Ryo, O.H., Yoon, H.S. and Schin, C.S. (1992). Kinetic
properties of a L-cysteine desulfhydrase-deficient mutant in the
enzymatic formation of L-cysteine from DL-ATC, Biotechnology
Letters, 14:1143-1148.
Paegle, L. and Ruklisha, M. (2003). Lysine synthesis control in
Corynebacterium glutamicum RC 115 in mixed substrate (glucose-
acetate) medium, Journal of Biotechnology, 104: 123-128.
Palsson, B.O. (2000). The challenges of in silico biology, Nature
Biotechnology, 18:1147-1150.
Palsson, B.O. (2006). Systems Biology Properties of Reconstructed
Networks, Cambridge University Press, New York, USA.
Papoutsakis, E. T. (1984). Equations and calculations for fermentations
of butyric acid bacteria, Biotechnology and Bioengineering, 26:
174–187.
Papoutsakis, E. T. and Meyer, C. L. (1985)a. Fermentation equations for
propionic acid bacteria and production of assorted oxychemicals
from various sugars, Biotechnology and Bioengineering, 27: 67–80.
Papoutsakis, E. T. and Meyer, C. L. (1985)b. Equations and calculations
of product yields and preferred pathways for butanediol and
mixed acid fermentations, Biotechnology and Bioengineering, 27:
50–66.
Park, S. et al. (1999). Metabolite and isotopomer balancing in the
analysis of metabolic cycles: II, Applications in Biotechnology and
Bioengineering, 62: 392–401.
Park, S. M., Shaw Reid, C., Sinskey, A. J. and Stephanopoulos, G.
(1997). Elucidation of anaplerotic pathways in Corynebacterium
S.K University – Department of Biotechnology, Anantapuram. Page 183
glutamicum via 13C-NMR spectroscopy and GC-MS, Applied
Microbiology and Biotechnology, 47: 430–440.
Patek, M., Eikmanns, B., Patek, J. and Sahm, H. (2007). Branched
Chain Amino Acids, in amino acid biosynthesis Pathways,
regulation and metabolic engineering, Springer, Heidelberg,
Germany, 778.
Patil, K.R., Akesson, M. and Nielsen, J. (2004). Use of genome scale
microbial models for metabolic engineering, Current Opinion in
Biotechnology, 15: 64-69.
Pelechova, J., Seifert, R. and Smekal, F. (1983). Biosynthesis of L-lysine
from paper hydrolyzate with Corynebacterium glutamicum and
Brevibacterium sp., KvasnyPrum, 29: 279-282.
Peters Wendisch, P., Eikmanns, B.J., Thierbach, G., Bachmann, B., and
Sahm,H. (1993). Phosphoenolpyruvate carboxylase in
Corynebacterium glutamicum is dispensable for growth and lysine
production, FEMS Microbiology Letters, 112: 269-274.
Peters Wendisch, P.G., Eikmanns, B. and Sahm, H. (1999). DE Patent
Application (19831609).
Peters Wendisch, P.G., Kreutzer, C., Kalinowski, J., Patek, M., Sahm, H.,
and Eikmanns, B.J. (1998). Pyruvate carboxylase from
Corynebacterium glutamicum: characterization, expression and
inactivation of the pyc gene, Microbiology, 144: 915-927.
Peters Wendisch, P.G., Schiel, B., Wendisch, V.F., Katsoulidis, E.,
Mockel, B., Sahm, H., and Eikmanns, B.J. (2001). Pyruvate
carboxylase is a major bottleneck for glutamate and lysine
production by Corynebacterium glutamicum, Journal of Molecular
Microbiology and Biotechnology, 3: 295-300.
Petersen, S., De Graff, A.A, Eggeling, L., Mollney, M., Wiechert, W. and
Sahm H. (2000). In vivo quantification of parallel and bidirectional
S.K University – Department of Biotechnology, Anantapuram. Page 184
fluxes in the anaplerosis of Corynebacterium glutamicum, Journal
of Biological Chemistry, 275: 35932-35941.
Petersen, S., Mack, C., De Graaf, A.A., Riedel, C., Eikmanns, B.J., and
Sahm, H. (2001). Metabolic consequences of altered
phosphoenolpyruvate carboxykinase activity in Corynebacterium
glutamicum reveal anaplerotic regulation mechanisms in vivo,
Metabolic Engineering, 3: 344-361.
Pfefferle, W., Mockel, B., Bathe, B. and Marx, A. (2003). Biotechnological
manufacture of lysine, Advances in Biochemical Engineering and
Biotechnology, 79: 59–112.
Pilat, P. and Paleckova, F. (1982). Two stage continuous biosynthesis of
L-lysine, KvasnyPrum, 28: 278-280.
Pissara, P.N., Nielsen, J. and Bazin, M.J. (1996). Pathway kinetics and
metabolic control analysis of a high-yielding strain of Penicillium
chrysogenum during fed batch cultivations, Biotechnology and
Bioengineering, 51: 168-176.
Plachys, J. and Ulbert, S. (1985). Preparation of lysine by mutants of
Corynebacterium, KvasnyPrum, 31: 159-160.
Polen, T. and Wendisch, V.F. (2004). Genome wide expression analysis
in amino acid-producing bacteria using DNA microarrays, Applied
Biochemistry and Biotechnology, 118: 215–232.
Powell, J.F and Strange, R.E. (1959). Photo tautomerization of Cytosine
derivatives on ultraviolet irradiation, Nature, 184: 878-882.
Powell, J.F. and Strange, R.E. (1957). α, ε- DAP Metabolism and
Sporulation in Bacillus sphaericus, Biochemistry Journal, 65: 700-
704.
Price, N.D, Papin, J.A, Schilling, C.H. and Palsson, B.O. (2003). Genome
scale microbial in silico models: the constrain-based approach.
Trends in Biotechnology, 21:162-169.
S.K University – Department of Biotechnology, Anantapuram. Page 185
Puech, V., Chami, M., Lemassu, A., Laneelle, M.A., Schiffler, B.,
Gounon, P., Bayan, N., Benz, R. and Daffe, M. (2001). Structure of
the cell envelope of corynebacteria: importance of the non-
covalently bound lipids in the formation of the cell wall
permeability barrier and fracture plane, Microbiology, 147: 1365-
1382.
Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A.,
Walsh, M. C., Berden, J.A., Brindle, K. M., Kell, D. B., Rowland, J.
J., Westerhoff, H. V., van Dam, K., and Oliver, S. G. (2001). A
functional genomics strategy that uses metabolome data to reveal
the phenotype of silent mutations, Nature Biotechnology, 19, 45-
50.
Ramachandran, G.N., Ramakrishnan, C. and Sasisekharan, V. (1963).
Stereochemistry of polypeptide chain configurations, Journal of
Molecular Biology, 7: 95–99.
Rao, S.B., Muralidhara, R.D. and Swamy, A.V.N. (2011). Studies on
continuous production kinectics of L-lysine by immobilized
Corynebacterium glutamicum 13032, Middle East Journal of
Scientific Research, 7(2): 235-240.
Reardon, K. F., Scheper, T. H. and Bailey, J. E. (1987). Metabolic
pathway rates and culture fluorescence in batch fermentations of
Clostridium aceto butylicum, Biotechnology in Progress, 3: 153–
167.
Reder, C. (1988). Metabolic control analysis: A structural approach,
Journal of Theortical Biology, 135: 175-201.
Reed, J.R., Vo, T.D., Schilling CH, Palsson B.O. (2003). An expanded
genome scale model of Escherichia coli K-12, Genome Research,
4:54.
Reynen, C., Haederich, B., Pfefferle, W., Eggeling, L., Sahm, H. and Patek, M.
(2006). (EP1619252).
S.K University – Department of Biotechnology, Anantapuram. Page 186
Rhuland, L.E. and Bannister, B. (1956). The biosynthesis of α, ε-
diaminopimelic acid, isolation of an intermediate, active for a
diaminopimelic acid requiring E. coli mutant, Journal of American
Chemical Society, 78: 3548.
Rhuland, L.E. and Hamilton, R.B. (1961). The functional pathway of
lysine biosynthesis in E. coli, Biochemistry Biophysics Acta, 51:
525-530.
Riedel, C., Eikmanns, B., Mockel, B. and Sahm, H. (1999). EU Patent
Application EP1094111.
Riedel, C., Rittmann, D., Dangel, P., Mockel, B., Sahm, H. and
Eikmanns, B.J. (2001). Characterization, expression, and
inactivation of the phosphoenolpyruvate carboxykinase gene from
Corynebacterium glutamicum and significance of the enzyme for
growth and amino acid production, Journal of Molecular
Microbiology and Biotechnology, 3: 573-583.
Rittmann, D., Lange, C., Wendisch, V.F, Bott, M. and Sahm, H. (2003).
Global expression profiling and physiological characterization of
Corynebacterium glutamicum grown in the presence of L-valine,
Applied and Environmental Microbiology, 69: 2521-2532.
Ro, D. et al. (2006). Production of the antimalarial drug precursor
artemisinic acid in engineered yeast, Nature, 440: 940–943.
Rollm, C., Morgan& V., Guyonvarch, A., and Guerquin Kern, J.L. (1995).
13C NMR studies of Corynebacterium melassecola metabolic
pathways, Eurupeon Journal of Biotechnology, 227: 488-493.
Roomi, M.W, Ivanov, V., Kalinovsky, T., Niedzwiecki, A. and Rath, M.
(2006). Antitumor effect of ascorbic acid, lysine, proline, arginine,
and green tea extract on bladder cancer cell line T-24, Internet
Journal of Urology, 13(4): 415-419.
Rossol, I. and Puhler, A. and Rouy, N. (1992). (US5133976).
S.K University – Department of Biotechnology, Anantapuram. Page 187
Rowlands, R.T. (1984). Industrial strain improvement: mutagenesis and
random screening procedures, Enzyme Microbial Technology, 6: 3-
10.
Ruklisha, M. and Paegle, L. (2001). Metabolic fluxes and L-lysine
synthesis by Corynebacterium glutamicum in relation to cellular
total reducing activity, Process Biochemistry, 36: 1233–1240.
Ruklisha, M., Paegle, L. and Denina I. (2007). L-Valine biosynthesis
during batch and fed batch cultivations of Corynebacterium
glutamicum: Relationship between changes in bacterial growth
rate and intracellular metabolism, Process Biochemistry, 42: 634-
640.
Sahm, H., Drysch, A., Massaoudi, M.El, Mack, C., Takors, R. and
DeGraaf, A.A. (2003). Production process monitoring by serial
mapping of microbial carbon flux distributions using a novel
Sensor Reactor approach: II-13C labeling-based metabolic flux
analysis and L-lysine production, Metabolic Engineering, 5: 96–
107.
Sahm, H., Eggeling, L. and De Graaf, A.A. (2000). Pathway analysis and
metabolic engineering in Corynebacterium glutamicum, Biological
Chemistry, 381: 899–910.
Sahm, H., Eggeling, L., Eikmanns, B. and Kramer, R. (1995). Metabolic
design in amino acid producing bacterium Corynebacterium
glutamicum, FEMS Microbiology Letters, 16: 243-252.
Samanta, T.K. and Bhattacharyya, R. (1991). L-lysine production by
5-2-Amino-ethyl-L-cystein resistant mutants of Arthrobacter
globiformis, Folia Microbiology, 36: 59-66.
Sambanthamurthi, R., Laverack, P.D. and Clarke, P.H. (1984). Lysine
excretion by mutant strain of Pseudomonas aeruginosa, FEMS
Microbiology Letters, 23: 11-15.
S.K University – Department of Biotechnology, Anantapuram. Page 188
Sambrook, J. and Russell, D. (2001). Molecular cloning, A laboratory
manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring
Harbor, NY, USA.
Sanders, C., Falco, C., Guida, T., Kitto, S., Mauvais, J. and Ward, T.
(1994). Overproduction of lysine in seeds of Brassica napus by
genetic engineering of the biosynthetic pathway, Plant Physiology,
105: 115-119.
Sano, K. and Shiio, I. (1970). Microbial production of L-lysine
production by mutants resistant to S-(2-Amino ethyl) L-cysteine,
General and Applied Microbiology, 16: 373-391.
Sano, K. and Tsuchida, T. (1982). (US4346170).
Sano, K., Ito, K., Miwa, K. and Nakamori, S. (1985). EU Patent
Application EP143195.
Sano, K., Ito, K., Miwa, K. and Nakamori, S. (1987). Amplification of the
phosphoenolpyruvate carboxylase gene of Brevibacterium lactofermentum
to improve amino acid production, Agriculture and Biological Chemistry,
51(2): 597–599.
Sano, K., Ito, K., Miwa, K. and Nakamori, S. (1988). (US4757009).
Sano, K., Ito, K., Miwa, K. and Nakamori, S. (1989). (US4861722).
Sano, K., Osumi, C., Matsui, K. and Miwa, K. (1990). (US4980285).
Sassi, A., Coello, N., Deschamps, A.M. and Lebeault, J.M. (1990). Effect
of medium composition on L-lysine production by variant strain of
Corynebacterium glutamicum ATCC-21513, Biotechnology Letters,
12(4): 294-296.
Sassi, A., Deschamps, A.M. and Lebeault, J.M. (1996). Process analysis
of L-lysine fermentation with Corynebacterium glutamicum under
different oxygen and carbon dioxide supplies and redox potentials,
Process Biochemistry, 31: 493-497.
S.K University – Department of Biotechnology, Anantapuram. Page 189
Sassi, A.H., Queric, M.P., Deschamps, A.M. and Lebeault, J.M. (1988).
Optimization of L-lysine production by Corynebacterium sp. in fed
batch cultures, Biotechnology Letters, 10: 583-586.
Sauer, U. (2004). High-throughput phenomics: Experimental methods for
mapping fluxomes, Current Opinion in Biotechnology, 15: 58–63.
Sauer, U. and Eikmanns, B.J. (2005). The PEP-pyruvate oxaloacetate node as the
switch point for carbon flux distribution in bacteria, FEMS Microbiology
Review, 29: 765–794.
Sauer, U., Cameron, D.C., and Bailey, J.E. (1998). Metabolic capacity of
Bacillus subtilis for the production of purine nucleotides,
riboflavin, and folic acid, Biotechnology and Bioengineering, 59:
227-238.
Sauer, U., Hatzimanikatis, V., Bailey, J.E, Hochuli, M., Szyperski, T. and
Wuthrich, K. (1997). Metabolic fluxes in riboflavin producing Bacillus
subtilis, Nature Biotechnology, 15: 448–452.
Schaffer, S. and Burkovski, A. (2005). Proteomics. CRC, Boca Raton, Fl, pp 99–
118
Schaffer, S., Weil, B., Nguyen, V.D., Dongmann, G., Gunther, K.,
Nickolaus, M., Hermann, T. and Bott, M. (2001). A high-resolution
reference map for cytoplasmic and membrane-associated proteins
of Corynebacterium glutamicum, Electrophoresis, 22: 4404-4422.
Schendel, F.J., Bremmon, C.E., Flickinger, M.C., Guettler, M. and
Hanson, R. (1990). L-lysine production at 50°C by mutant of a
newly of a newly isolated and characterized methylotrophic
Bacillus sp, Applied and Environmental Microbiology, 56: 963-970.
Schilling, C.H, Covert, M.W, Famili, I., Church, G.M., Edwards, J.S. and
Palsson, B.O. (2002). Genome scale metabolic model of
Helicobacter pylori 26695, Journal of Bacteriology, 184: 4582-
4593.
S.K University – Department of Biotechnology, Anantapuram. Page 190
Schilling, C.H. and Palsson, B.O. (2000). Assessment of the metabolic
capabilities of Haemophilus influenzae Rd through a genome scale
pathway analysis, Journal of Theoretical Biology, 203: 249-283.
Schilling, C.H., Schuster, S., Palsson, B.O., and Heinrich, R. (1999).
Metabolic pathway analysis: basic concepts and scientific
applications in the post genomic era, Biotechnology Progress, 15:
296-303.
Schluesener, D., Fischer, F., Kruip, J., Rogner, M. and Poetsch, A. (2005).
Mapping the membrane proteome of Corynebacterium glutamicum,
Proteomics, 5: 1317–1330.
Schmid, R., Uhlemann, E.M., Nolden, L., Wersch, G., Hecker, R.,
Hermann. T., Marx, A. and Burkovski, A. (2000). Response to
nitrogen starvation in Corynebacterium glutamicum, FEMS
Microbiology Letters, 187: 83-88.
Schreiter, E.R, Sintchak, M.D., Guo, Y. Chivers, P.T. Sauer, R. T. and
Drennan, C.L. (2003). Crystal structure of the nickel responsive
transcription factor NikR, Nature Structral Biology, 10: 794–799.
Schrumpf, B., Eggeling, L. and Sahm, H. (1992). Isolation and prominent
characteristics of an L-lysine hyperproducing strain of Corynebacterium
glutamicum, Applied Microbiology and Biotechnology, 37: 566–571.
Schrumpf, B., Schwarzer, A., Kalinowski, J., Puhler, A., Eggeling, L. and
Sahm, H. (1991). A functionally split pathway for lysine synthesis
in Corynebacterium glutamicum, Journal of Bacteriology, 173:
4510- 4516.
Schuller, D.J, Grant, G.A. and Banaszak, L.J. (1995). The allosteric
ligand site in the Vmax-type cooperative enzyme phosphoglycerate
dehydrogenase, Nature Structural Biology, 2: 69–76.
Schuster, S., Hilgetag, C., Woods, J.H and Fell, D. A. (2002). Reaction routes in
biochemical reaction systems: Algebraic properties, validated calculation
S.K University – Department of Biotechnology, Anantapuram. Page 191
procedure and example from nucleotide metabolism, Journal of Molecular
Biology, 45: 153–181.
Schwarzer, A. and Puhler, A. (1991). Manipulation of Corynebacterium
glutamicum by gene disruption and replacement, Biotechnology, 9:
84-87.
Seep Feldhaus, A.H., Kalinowski, J. and Puhler, A. (1991). Molecular
analysis of the Corynebacterium glutamicum Lys I gene involved in
lysine uptake, Molecular Microbiology, 5: 2995-3005.
Seibold, G., Auchter, M., Berens, S., Kalinowski, J., and Eikmanns, B.J.
(2006). Utilization of soluble starch by a recombinant
Corynebacterium glutamicum strain: Growth and lysine
production, Journal of Biotechnology, 124: 381-391.
Sen, S.K. (1985). Isolation method of lysine over producers from
hydrocarbon utilize, Acta Biotechnology, 5: 379-381.
Sen, S.K. and Chatterjee, S.P. (1985). Influence of antibiotics and trace
salts on lysine production by Arthrobacter globiformis, Acta
Biotechnology, 5: 215-218.
Sen, S.K., Chatterjee, M. and Chatterjee, S.P. (1983). L-lysine
production from hydrocarbons by Micrococcus varians, Acta
Microbiology, 32: 139-145.
Seng Wong, T. et al. (2004). Laboratory evolution of cytochrome P450
BM-3 monooxygenase for organic cosolvents, Biotechnology and
Bioengineering, 85: 351–358.
Serebrijski, I., Wojcik, F., Reyes, O. and Leblon, G. (1995). Multicopy
suppression by asd gene and osmotic stress dependent
complementation by heterologous pro A in pro A mutants, Journal
of Bacteriology, 177: 7255-7260.
S.K University – Department of Biotechnology, Anantapuram. Page 192
Shah, A.H., Hameed, A. and Khan, G.M. (2002). Fermentative
production of L-lysine, Bacterial fermentation, Journal of Medicinal
Science, 2(3): 152-157.
Shannon, P. et al. (2003). Cytoscape: a software environment for
integrated models of biomolecular interaction networks, Genome
Research, 13: 2498–2504.
Shaw Reid, C.A., McCormick, M.M., Sinskey, A.J., and Stephanopoulos.
(1999). Flux through the tetra hydrodipicolinate succinylase
pathway is dispensable for L-lysine production in Corynebacterium
glutamicum, Applied Microbiology and Biotechnology, 51: 325-333.
Shen, X.H, Jiang, C.Y, Huang, Y., Liu, Z.P. and Liu, S.J. (2005).
Functional identification of novel genes involved in the
glutathione-independent gentisate pathway in Corynebacterium
glutamicum, Applied and Environmental Microbiology, 71(7): 344-
352.
Shiio, I. (1990). Threonine production by dihydrodipicolinate synthase-
defective mutants of Brevibacterium flavum, Biotechnology
Advances, 8: 97-103.
Shiio, I. and Mfyajima, R. (1969). Concerted inhibition and its reversal
by end products of aspartate kinase in Brevibacterium flavum,
Journal of Biochemistry, 65: 849-859.
Shiio, I., Sano, K. and Nakamori, S. (1972). (US3707441).
Shiio, I., Sugimoto, S. and Kawamura, K. (1993). Isolation and
properties of α-ketobutyrate resistant lysine producing mutants
from Brevibacterium flavum, Bioscience, Biotechnology and
Biochemistry, 57: 50-55.
Shiio, I., Toride, Y., Yokota, A., Sugimoto, S. and Kawamura, K. (1991).
Process for the production of L-threonine by fermentation, U.S.A
Patent [5077207].
S.K University – Department of Biotechnology, Anantapuram. Page 193
Shimizu, H., Takiguchi, N., Tanaka, H. and Shioya, S. (1999).
A maximum production strategy of lysine based on a simplified
model derived from a metabolic reaction network, Metabolic
Engineering, 1(4): 299-308.
Shimizu, K., Hua, Q., and Yang, C. (2000). Metabolic Control Analysis
for Lysine Synthesis Using Corynebacterium glutamicum and
Experimental Verification, Journal of Bioscience and
Bioengineering, 90 (2): 184-192.
Shimura, Y., and H. J. Vogel. (1966). Diaminopimelate decarboxylase of
Lemna perkusilla: partial purification and some properties,
Biochemistry and Biophysics Acta, 118:396-404.
Shlossar, P.M., Holocomb, T., and Bailey, J.E. (1993). Determining
metabolic sensitivity coefficients directly from experimental data,
Biotechnology and Bioengineering, 41: 1027-1038.
Shokuo, K., Kiyoshi, N. and Sohei, K. (1961). (US2979439).
Shpaer, E.G., Robinson, M., Yee, D., Candlin, J.D., Mines, R., and
Hunkapiller, T. (1996). Sensitivity and selectivity in protein
similarity searches: A comparison of Smith-Waterman in
hardware to BLAST and FASTA, Genomics, 38: 179-191.
Shukuo, K., Kiyoshi, N. and Sohei, K. (1961). (US2979439).
Silberbach, M., Schafer, M., Huser, A.T., Kalinowski, J., Puhler, A., Kramer, R.
and Burkovski, A. (2005). Adaptation of Corynebacterium glutamicum to
ammonium limitation: A global analysis using transcriptome and
proteome techniques, Applied and Environmental Microbiology, 71: 2391–
2402.
Sindelar, G. and Wendisch, V.F. (2007). Improving lysine production by
Corynebacterium glutamicum through DNA microarray-based
identification of novel target genes, Applied Microbiology and
Biotechnology, 76: 677–689.
S.K University – Department of Biotechnology, Anantapuram. Page 194
Smekal, F., Barta, M., Bulant, V. and Ulbert, S. (1984). Biosynthesis of
L-lysine with phospocarpus flour as nitrogen source, KvasnyPrum,
30: 133-136.
Smekal, F., Bulant, V., Kindlova, E., Mazalova, M. and Ulbert S. (1982).
Production of L-lysine using non standard nitrogen sources,
KvasnyPrum, 28: 39-40.
Smekal, F., Ulber, S. and Barta, M. (1985). L-lysine production with
regular mutants of Corynebacterium glutamicum, KvasnyPrum, 31:
282-283.
Smekel F. (1984). Fermentation production of L-lysine, Czech CS, Chem
abs, 100: 203-205
Smekel, F., Pelechova, J., Sirochova, E., Zdanova, N. and Lenova, T.
(1988). Biochemical and production properties of Corynebacterium
glutamicum strains, Kvasnyprum, 34 (1): 12-19.
Smirnov, V.V, Sergeichuk, M.G, Mikhalsky, L.A. and Zgonvik, V.V.
(1994). Biological peculiarities of bacteria of Azomonas genus
contaminating the process of lysine production, Mikrobiol Zh, 56:
35-40.
Smriga, M. and Torii, K. (2003). Prolonged treatment with L-lysine and
L-arginine reduces stress-induced anxiety in an elevated plus
maize, Nature Neuroscience, 6(2): 125-128.
Smriga, M., Ghosh, V., Mouneimne, S., Pellett, A. and Scrimshaw, R.
(2004). Lysine fortification reduces anxiety and lessens stress in
family members in economically weak communities in Northwest
Syria, Journal of Proteome Research, 101: 67-72.
Smriga, M., Kameishi, G., Uneyama, D. and Torii, K. (2002). Dietary
L-lysine deficiency increases stress induced anxiety and fecal
excretion in Rats, Nature Neuroscience, 5(1): 105-110.
S.K University – Department of Biotechnology, Anantapuram. Page 195
Sobotkova, A., Sikyta, B. and Smekal, F. (1989). Production of lysine by
mutants of Escherichia coli K12 in medium with lactose, Acta
Biotechnology, 9: 173-177.
Soga, T. et al. (2003). Quantitative metabolome analysis using capillary
electrophoresis mass spectrometry, Journal of Proteome Research,
2: 488–494.
Sonntag, K., Eggeling, L., De Graaf, A.A. and Sahm, H. (1993). Flux
partitioning in the split pathway of lysine synthesis in
Corynebacterium glutamicum, European Journal of Biochemistry,
213: 1325-1331.
Sonntag, K., Eggeling, L., De Graaf, A.A. and Sahm, H. (1993). Flux partitioning
in the split path- way of lysine synthesis in Corynebacterium glutamicum.,
Eurupeon Journal of Biochemistry, 213: 1325–1331.
Sonntag, K., Schwinde, J.W., De Graaf, A.A., Marx, A., Eikmanns, B.J.,
Wiechert, W. and Sahm, H. (1995). 13C NMR studies of the fluxes
in the central metabolism of Corynebacterium glutamicum during
growth and overproduction of amino acids in batch cultures,
Applied Microbiology and Biotechnology, 44: 489-495.
Sritharan, V., Wheeler, P.R. and Ratledge, C. (1990). Aspartate
metabolism in Mycobacterium avium grown in host tissue and
axenically and in Mycobacterium lepme, Journal of General
Microbiology, 136: 203-209.
Stackebrandt, E, and Woese, C.R. (1981). The evolution of prokaryotes
in Molecular and Cellular Aspects of Microbial Evolution,
Cambridge University Press, 34: 1–31.
Stackebrandt, E., Rainey, F.A., and Ward Rainey, N.L. (1997). Proposal
for a new hierarchical classification system, Actinobacteria classis
nov, Internet Journal of Systematic Bacteriology, 47: 479-491.
S.K University – Department of Biotechnology, Anantapuram. Page 196
Stephanopoulos, G. (1999). Metabolic fluxes and metabolic engineering,
Metabolic Engineering, 1: 1–11.
Stephanopoulos, G. and Vallino, J.J. (1991). Network rigidity and
metabolic engineering in metabolite overproduction, Science,
252:1675-1681.
Stephanopoulos, G. et al. (2004). Exploiting biological complexity for
strain improvement through systems biology, Nature
Biotechnology, 22: 1261–1267.
Stephanopoulos, G., Hwang, D., Schmitt, W.A. and Misra, J. (2002).
Mapping physiological states from microarray expression
measurements, Bioinformatics, 18: 1054-1063.
Stephanopoulos, G.N., Aristidou, A.A., and Nielsen, J. (1998). Metabolic
Engineering Principles and Methodologies, Academic Press, San
Diego, USA.
Stevens, J.M. and Binder, T.P. (2000). (US20006017555).
Stevens, J.M. and Binder, T.P. (2003). (TW0521996B).
Stevens, J.M. and Binder, T.P. (2004). (EP0923878B1).
Storn, R. and Price, K. (1995). Differential evolution: a simple and
efficient adaptive scheme for global optimization over continuous
spaces, Technical report, 79: 95-102.
Strassman, M. and Weinhouse, S. (1953). Biosynthetic pathway in the
biosynthesis of lysine by Torulopsis utilis, Journal of American
Chemical Society, 75: 1680-1684.
Strelkov, S., Elstermann, M. and Schomburg, D. (2004). Comprehensive
analysis of metabolites in Corynebacterium glutamicum by gas
chromatography or mass spectrometry, Journal of Biological
Chemistry, 385: 853-861.
S.K University – Department of Biotechnology, Anantapuram. Page 197
Sugimoto, M., Ogawa, Y., Suzuki, T., Tanaka, A. and Matsui, H. (1997)
US Patent (5688671).
Sugimoto, M., Tanaka, A., Suzuki, T., Matsui, H., Nakamori, S. and Takagi, H.
(1997). Sequence analysis of functional regions of homoserine
dehydrogenase genes from L-lysine and L-threonine-producing mutants of
Brevibacterium lactofermentum, Bioscience, Biotechnology and
Biochemistry, 61: 1760–1762.
Sugimoto, M., Usuda, Y., Suzuki, T., Tanaka, A. and Matsui, H. (1998).
(US5766925).
Sumio, K., Kazumi, A., Katsumi, A. and Yoshimasa, T. (1972). (US3687810).
Sung, Y.H. et al. (2005). Influence of down regulation of caspase-3 by
siRNAs on sodium butyrate induced apoptotic cell death of
Chinese hamster ovary cells producing thrombopoietin, Metabolic
Engineering, 7: 457–466.
Suthers, P.F. and Cameron, D.C. (2001). Production of
3-hydroxypropionic acid in recombinant organisms, PCT (WO
0116346).
Tanaka, K., Saeki, M., Matsuishi, T., Koga, Y. and Kawakita, T. (1987).
(US4714767).
Tanaka, T., Nakamura, Y., Asahi, K., Shiraishi, T. and Takahara, K. (1978).
(US4123329A).
Tateno, T., Fukuda, H. and Kondo, A. (2007). Direct production of
L-lysine from raw corn starch by Corynebacterium glutamicum
secreting Streptococcus bovisalphaamylase using cspB promoter
and signal sequence, Applied Microbiology and Biotechnology, 77:
533–541.
Tateno, T., Fukuda, H. and Kondo, A. (2007). Production of L-lysine
from starch by Corynebacterium glutamicum displaying alpha-
S.K University – Department of Biotechnology, Anantapuram. Page 198
amylase on its cell surface, Applied Microbiology and
Biotechnology, 74: 1213–1220.
Tatum, E. L. and Beadle, G. W. (1945). Methods of producing and
detecting mutations concerned with nutritional requirements,
American Journal of Botany, 32: 678-686.
Tauch, A., Homann, I., Mormann, S., Ruberg, S., Billault, A., Bathe, B., Brand,
S., Brockmann- Gretza, O., Ruckert, C., Schischka, N., Wrenge,r C.,
Hoheisel, J., Mockel, B., Huthmacher, K., Pfefferle, W., Puhler, A. and
Kalinowski, J. (2002). Strategy to sequence the genome of
Corynebacterium glutamicum ATCC 13032: Use of a cosmid and a
bacterial artificial chromosome library, Journal of Biotechnology, 95: 25–
38.
Tauch, A., Kaiser, O., Hain, T., Goesmann, A., Weisshaar, B., Albersmeier, A.,
Bekel, T., Bischoff, N., Brune, I., Chakraborty, T., Kalinowski, J., Meyer,
F., Rupp, O., Schneiker, S., Viehoever, P. and Puhler, A. (2005). Complete
genome sequence and analysis of the multiresistant nosocomial pathogen
Corynebacterium jeikeium K-411, a lipid requiring bacterium of the human
skin flora, Journal of Bacteriology, 187: 4671–4682.
Teusink, B., Wiersma, A., Molenaar, D., Francke, C., De Vos, W.M.,
Siezen, R.J. and Smid, E.J. (2006). Analysis of growth of
Lactobacillus plantarum WCFS1 on a complex medium using a
genome scale model, Journal of Biological Chemistry, 281: 40041-
40048.
Thierbach, G., Kalinowski, J., Bachmann, B. and Puhler, A. (1990).
Cloning of a DNA fragment from Corynebacterium glutamicum
conferring aminoethyl cysteine resistance and feedback resistance
to aspartokinase, Applied Microbiology and Biotechnology, 32:
443–448.
Tian, J. et al. (2004). Accurate multiplex gene synthesis from
programmable DNA microchips, Nature, 432: 1050–1054.
S.K University – Department of Biotechnology, Anantapuram. Page 199
Tilg, Y., Eikmanns, B., Eggeling, L., Sahm, H. and Mockel, B. (1999). EU
Patent Application (EP1055725).
Tilg, Y., Eikmanns, B., Eggeling, L., Sahm, H. and Mockel, B. (2002).
(US20026361986).
Tilg, Y., Eikmanns, B., Eggeling, L., Sahm, H., Mockel, B. and Pfefferle, W. (2002)
(US20026379934).
Tosaka, O., Enei, H. and Hirose, Y. (1983). The production of lysine by
fermentation, Trend in Biotechnology, 1: 71-74.
Tosaka, O., Hirakawa, H. and Hirose Y. (1978). Regulation of lysine
biosynthesis by leucine in Brevibacterium lactofermentum,
Microbiology, 42(8): 1501.
Tosaka, O., Hirakawo, H. and Takinami, K. (1979). Effect of biotin level
on L-lysine formation in Brevibacterium lactofermentum, Journal of
Biochemistry, 43: 491-495.
Tosaka, O., Morioka, H., Hirakawa, H., Ishii, K., Kubota, K. and Hirose, Y. (1978).
(US4066501).
Tosaka, O., Ono, E., Ishihara, M., Morioka, H. and Takinami, K. (1981).
(US4275157).
Trifonova, V.V., Ignatova, N.I., Milyukova, T.B., Overchenko, M.B. and
Rimareva, L.V. (1993). Possible application of various types of fruit
and vegetable raw materials to microbial synthesis of lysine, Prikl
Biokhim Mikrobiol, 29: 475-479.
Tweeddale, H., Notley McRobb, L. and Ferenci, T. (2006). High
throughput screen for poly-3- hydroxybutyrate in Escherichia coli
and Synechocystis sp. Strain PCC6803, Applied and
Environmental Microbiology, 72: 3412–3417.
S.K University – Department of Biotechnology, Anantapuram. Page 200
Udaka, S. (1960). Screening method for microorganisms accumulating
metabolites and its use in the isolation of Micrococcus glutamicus, Journal
of Bacteriology, 79: 754–755.
Uy, D., Delaunay, S., Engasser, J.M. and Goergen, J.L., (1999). A
method for the determination of pyruvate carboxylase activity
during the glutamic acid fermentation with Corynebacterium
glutamicum, Journal of Microbiology Methods, 39: 91-96.
Vallino, J. J. (1991). Identification of Branch Point Restrictions in
Microbial Metabolism through Metabolic Flux Analysis and Local
Network Perturbations, Ph.D. Thesis, Massachusetts Institute of
Technology, Cambridge, MA.
Vallino, J. J. and Stephanopoulos, G. (1987). Intelligent Sensors in
Biotechnology: Applications for the Monitoring of Fermentations
and Cellular Metabolism, Annual New York Academic Science,
506: 413-430.
Vallino, J. J. and Stephanopoulos, G. (1993). Metabolic flux distribution
in Corynebacterium glutamicum during growth and lysine
overproduction, Bioprocess Engineering, 41: 633-646.
Vallino, J. J. and Stephanopoulos, G. (1994) a. Carbon flux distributions
at the glucose 6-phosphate branch point in Corynebacterium
glutamicum during lysine overproduction, Biotechnology Progress,
10: 327-334.
Vallino, J. J. and Stephanopoulos, G. (1994) b. Carbon flux
distributions at the pyruvate branch point in Corynebacterium
glutamicum during lysine overproduction, Biotechnology Progress,
10: 320-326.
Vander Heijden, R. T. J. M., Heijnen, J. J., Hellinga, C., Romein, B. and
Luyben, K. (1994) a. Linear constraint relations in biochemical
reaction systems: I. Classification of the calculability and the
S.K University – Department of Biotechnology, Anantapuram. Page 201
balanceability of conversion rates, Biotechnology and
Bioengineering, 43: 3-10.
Vander Heijden, R. T. J. M., Heijnen, J. J., Hellinga, C., Romein, B., and
Luyben, K. (1994) b. Linear constraint relations in biochemical
reaction systems: II. Diagnosis and estimation of gross
measurement errors, Biotechnology and Bioengineering, 43: 11-20.
Varela, C.A., Baez, M.E. and Agosin, E. (2004). Osmotic stress response:
Quantification of cell maintenance and metabolic fluxes in a lysine
overproducing strain of Corynebacterium glutamicum, Applied and
Environmental Microbiology, 70: 4222-4229.
Varma, A., Boesch, B. W. and Palsson, B. O. (1993). Stoichiometric
interpretation of Escherichia coli glucose catabolism under various
oxygenation rate, Applied and Environmental Microbiology, 59:
2465-2473.
Varma, A., Boesch, B. W., and Palsson, B. O. (1993). Biochemical
production capabilities of Escherichia coli, Biotechnology and
Bioengineering, 42: 59-73.
Vasicova, P., Patek, M., Nesvera, J., Sahm, H. and Eikmanns, B. (1999). Analysis
of the Corynebacterium glutamicum dapA promoter, Journal of
Bacteriology, 181: 6188–6191.
Velasco, A.M., Leguina, J.I. and Lazcano, A. (2002). Molecular Evolution of the
Lysine Biosynthetic Pathways, Journal of Molecular Evolution, 55: 445–
459.
Venter, C. and Cohen, D. (2004). The Century of Biology, New Perspect,
21: 73–77.
Vertes, A.A., Inui, M. and Yukawa, H. (2005). Manipulating
corynebacteria, from individual genes to chromosome, Applied and
Environmental Microbiology, 71: 7633– 7642.
S.K University – Department of Biotechnology, Anantapuram. Page 202
Villas Boas, S.G. et al. (2005). High throughput metabolic state analysis:
the missing link in integrated functional genomics of yeasts,
Biochemistry Journal, 388: 669–677.
Voigt, C.A. et al. (2002). Protein building blocks preserved by
recombination, Nature Structural Biology, 9: 553–558.
Von der Osten, C.H., Barbas, C.F., Wong, C.H. and Sinskey, A.J. (1989).
Molecular cloning, nucleotide sequence and fine structural
analysis of the Corynebacterium glutamicum fda gene: structural
comparison of C. glutamicum fructose-1, 6-biphosphate aldolase
to class I and class II aldolases, Molecular Microbiology, 3: 1625-
1637.
Von Graevenitz, A. and Bernard, K. (2001). The genus Corynebacterium
medical. In The Prokaryotes: A Handbook on the Biology of
Bacteria, Vol. 3: Archaea and Bacteria: Firmicutes, Actinomycetes,
Springer, New York, 819–842.
Vrljic, M., Eggeling, L. and Sahm, H. (1995). Patent Application (DE
19548222).
Vrljic, M., Garg, J., Bellmann, A., Wachi, S., Freudl, R., Malecki, M.J.,
Sahm, H., Kozina, V.J., Eggeling, L. and Saier, M.H. (1999). The
LysE superfamily: Topology of the lysine exporter LysE of
Corynebacterium glutamicum, a paradyme for a novel superfamily
of transmembrane solute translocators, Journal of Molecular
Microbiology and Biotechnology, 1: 327–336.
Vrljic, M., Sahm, H. and Eggeling, L. (1996). A new type of transporter
with a new type of cellular function: L-lysine export from
Corynebacterium glutamicum, Molecular Microbiology, 22: 815-826.
Walsh, K. and Koshland, D.E. (1985). Branch point control by the
phosphorylation state of isocitrate dehydrogenase, Journal of
Biological Chemistry, 260: 8430-8437.
S.K University – Department of Biotechnology, Anantapuram. Page 203
Wam, O.J, Lee, J.H., Noh, K.S., Lee, H.H., Lee, J.H. and Hyun, H.H.
(1991). Improved of L-lysine production by the amplification of the
Corynebacterium glutamicum dapA gene encoding
dehydrodipicolinate synthetase in E. coli, Biotechnology Letters,
13: 727-732.
Wang, J.S, Kuo, Y.C, Chang, C.C. and Liu, Y.T. (1991). Optimization of
culture conditions of L-lysine fermentation by Brevibacterium
species, Nature Biotechnology, 68: 154–159.
Wang, N. S. and Stephanopoulos, G. (1983). Application of macroscopic
balances to the identification of gross measurement errors,
Biotechnology and Bioengineering, 25: 2177–2208.
Ward, M. et al. (2004). Characterization of humanized antibodies
secreted by Aspergillus niger, Applied and Environmental
Microbiology, 70: 2567–2576.
Watson, and James D. (2007). Recombinant DNA: genes and genomes: a
short course. San Francisco: W.H. Freeman, ISBN 0-7167-2866-4.
Weber, W. et al. (2004). Gas inducible transgene expression in
mammalian cells and mice, Microbiology, 140: 249-251.
Weckbecker, C. and Hummel, W. (2004). Making L fom D in a single cell
Elements 06: 34–37. Available from World Wide Cited 15 April
2005.
Wehrmann, A., Eggeling, L. and Sahm, H. (1994). Analysis of different
DNA fragments of Corynebacterium glutamicum complementing
dapE of Escherichia coli, Microbiology, 140: 3349-3356.
Wehrmann, A., Phillipp, B., Sahm, H. and Eggeling, L. (1998). Different
modes of diaminopimelate synthesis and their role in cell wall
integrity: A study with Corynebacterium glutamicum, Journal of
Bacteriology, 180: 3159–3165.
S.K University – Department of Biotechnology, Anantapuram. Page 204
Wendisch, V.F, Marx, A. and Buchholz, S. (2005). Towards integration of
biorefinary and microbial amino acid production. In: biorefineries,
biobased industrial processes and products, Journal of
Bacteriology, 182: 3088.
Wendisch, V.F, Bott, M., Kalinowski, J., Oldiges, M. and Wiechert, W. (2006).
Emerging Corynebacterium glutamicum systems biology, Journal of
Biotechnology, 124: 74–92.
Wendisch, V.F. (2003). Genome-wide expression analysis in
Corynebacterium glutamicum using DNA microarrays, Journal of
Biotechnology, 104: 273-285.
Wendisch, V.F. (2006). Genetic regulation of Corynebacterium
glutamicum metabolism, Journal of Microbiology and
Biotechnology, 16: 999.
Wendisch, V.F. and Bott, M. (2005). In Handbook of Corynebacterium
glutamicum, CRC Press, Taylor & Francis, Boca Raton, FL, USA,
377–396.
Wendisch, V.F., De Graaf, A.A., Sahm, H. and Eikmanns, B.J. (2000).
Quantitative determination of metabolic fluxes during co
utilization of two carbon sources: comparative analyses with
Corynebacterium glutamicum during growth on acetate and/or
glucose, Journal of Bacteriology, 182: 3088-3096.
Wendisch, V.F., De Graaf, A.A., Sahm, H., and Eikmanns, B.J. (2000).
Quantitative determination of metabolic fluxes during co-
utilization of two carbon sources: Comparative analyses with
Corynebacterium glutamicum during growth on acetate and
glucose, Journal of Bacteriology, 182: 3088-3096.
Werning, H., Voss, H., Pfefferle, W. and Leuchtenberger, W. (1998). (US5840551).
S.K University – Department of Biotechnology, Anantapuram. Page 205
Weuster Botz, D. (1997). Sampling tube device for monitoring
intracellular metabolite dynamics, Analytical Biochemistry, 246:
225–233.
While, P. J. and Kelly, B. (1965). Purification and properties and
diaminopimelate decarboxylase from E. coli, Biochemistry Journal,
96: 75-78.
White, P. J. (1983). The essential role of diaminopimelate dehydrogenase in the
biosynthesis of lysine by Bacillus species, Journal of General Microbiology,
129: 739–749.
Whites, P.J. (1972). The nutrition of Bacillus mageterium and Bacillus
careus, Journal of General Microbiology, 71: 505-515.
Wiechert, W. (2001). 13 C metabolic flux analysis, Metabolic Engineering,
3: 195–206.
Wiechert, W. (2002). An introduction to 13C metabolic flux analysis,
Genetic Engineering, New York, 24: 215-238.
Wiechert, W. and Noh, K. (2005). From stationary to instationary metabolic flux
analysis, Advances in Biochemical Engineering and Biotechnology, 92:
145–172.
Wiechert, W., Mollney, M., Petersen, S. and De Graaf, A.A. (2001). A
universal framework for 13C metabolic flux analysis, Metabolic
Engineering, 3: 265-283.
Wiegand, T. and Moore, K. (2004) (US20046756510).
Wiley, V.C.H., Weinheim Woeltinger, J., Karau, A., Leuchtenberger, W.
and Drauz, K. (2005). Membrane reactors at Degussa. Advances in
Biochemical Engineering and Biotechnology, vol 92: pp 289–316.
Windass, J. D., Worsey, M. J., Pioli, E. M., Pioli, D., Barth, P. T.,
Atherton, K. T. and Dart, E. C. (1980). Improved conversion of
S.K University – Department of Biotechnology, Anantapuram. Page 206
methanol to single cell protein by Methyllophilus methylotrophus,
Nature, 287: 396-401.
Windor, E. (1951). α-Amino adipic acid as a precursor to lysine in
Neurospora, Journal of Biological Chemistry, 192: 607-611.
Wittmann, C. and Becker, J. (2007). The L-lysine story: from metabolic
pathways to industrial production. In: Wendisch VF Amino acid
biosynthesis-pathways, regulation and metabolic engineering.
Springer, Heidelberg, Germany.
Wittmann, C. and Heinzle, E. (2001). Application of MALDI-TOF MS to
lysine producing Corynebacterium glutamicum: A novel approach
for metabolic flux analysis, European Journal of Biochemistry,
268: 2441-2455.
Wittmann, C. and Heinzle, E. (2001). MALDI-TOF MS for quantification of
substrates and products in cultivations of Corynebacterium glutamicum,
Biotechnology and Bioengineering, 72: 642–647.
Wittmann, C. and Heinzle, E. (2002). Genealogy profiling through strain
improvement by using metabolic network analysis: metabolic flux
genealogy of several generations of lysine-producing
Corynebacteria, Applied and Environmental Microbiology, 68:
5843-5859.
Wittmann, C. Kim, H.M. and Heinzle, E. (2004). Metabolic network analysis of
lysine producing Corynebacterium glutamicum at a miniaturized scale,
Biotechnology and Bioengineering, 87: 1–6.
Wittmann, C., Kiefer, P. and Zelder, O. (2004). Metabolic fluxes in
Corynebacterium glutamicum during lysine production with
sucrose as carbon source, Applied and Environmental
Microbiology, 70: 7277-7287.
Wolf, A., Kramer, R. and Morbach, S. (2003). Three pathways for
trehalose metabolism in Corynebacterium glutamicum ATCC 13032
S.K University – Department of Biotechnology, Anantapuram. Page 207
and their significance in response to osmotic stress, Molecular
Microbiology, 49: 1119–1134.
Work E. (1951). The isolation of α, ε-DAP from Corynebacterium
diphtheriae and Mycobacterium tuberculosis, Journal of
Biochemistry, 49: 17-22.
Yan, Y. et al. (2005). Biosynthesis of natural flavanones in
Saccharomyces cerevisiae, Applied and Environmental
Microbiology, 71: 5610–5613.
Yarmush, M. L. and Berthiaume, F. (1997). Metabolic Engineering and
Human Disease, Nature Biotechnology, 15: 525-528.
Yeh, P., Sicard, A.M. and Sinskey A. J. (1988). Nucleotide sequence of
the lysA gene of Corynebacterium glutamicum and possible
mechanisms for modulation of its expression, Molecular General
Genetics, 212: 112-119.
Yeh, P., Sicard, A.M. and Sinskey, A. J. (1988). General organization of
the genes specifically involved in the diaminopimelate lysine
biosynthetic pathway of Corynebacterium glutamicum, Molecular
General Genetics, 212: 105-111.
Yokoi, H., Ohnishi, J., Ochiai, K. and Yonetani, Y. (2000). Novel
desensitized aspartokinase, PCT Patent Application No.
(WO0063388).
Yokomori, M., Totsuka, K., Kawahara, Y., Miwa, H. and Osumi, T. (1994)
(US5304476).
Yokota, A. and Lindley, N.D. (2005). Central metabolism: Sugar uptake and
conversion. In: (Eggeling L, Bott M) Handbook of Corynebacterium
glutamicum, CRC, Boca Raton, Fl, pp 215–240.
Yokota, A. and Shiio, I. (1988). Effect of reduced citrate synthetase
activity and feedback resistance phosphoenol pyruvate
S.K University – Department of Biotechnology, Anantapuram. Page 208
carboxylase on lysine production of Brevibacterium flavum
mutants, Agriculture and Biological Chemistry, 52: 455-463.
Yoshihara, Y., Kawahara, Y. and Ikeda, S. (1993). (US5179010).
Yoshikuni, Y. et al. (2006). Designed divergent evolution of enzyme
function, Nature, 440: 1078–1082.
Yoshioka, T., Ishii, T., Kawahara, Y., Koyma, Y. and Shimizu, E. (1999).
(US5869300).
Young, T.K. and Chipley, J.R. (1983). Microbial production of lysine and
threonine from whey permeate, Applied and Environmental
Microbiology, 45: 610-615.
Young, T.K. and Chipley, J.R. (1984). Role of biotin in the production of
lysine by Brevibacterium lactofermentum, Microbiology, 40: 161-
171.
Yugari, Y. and Gilvarg, C. (1962). Coordinated end product inhibition in
lysine biosynthesis in E. coli, Biochemistry and Biophysics Acta,
62: 612-615.
Zahl, K. J., Rose, C. and Hanson, R. L. (1978). Isolation and partial
characterization of a mutant of Escherichia coli lacking pyridine
nucleotide transhydrogenase, Archives of Biochemistry and
Biophysics, 190: 598–602.
Zaitseva, Z.M. and Konovalova, L.V. (1986). Threonine and methionine
regulation of the lysine biosynthesis in homoserine dependent
mutants of Corynebacteria, PriklBiochim Microbiology, 22: 348-
355.
Zakataeva, N.P, Aleshin, V.V, Tokmakova, I.L, Troshin, P.V. and
Livshits, V.A. (1999). The novel transmembrane Escherichia
coli proteins involved in the amino acid efflux, FEBS Letters, 452:
228–232.
S.K University – Department of Biotechnology, Anantapuram. Page 209
Zaki, D., Aziz, M.A., Naguib, M. and Shalabi, A. (1987). Effect of non
ionic detergents and vitamin on the amino acid synthesis by
Brevibacterium ammoniagenes, Zentralel Mikrobiology, 142: 333-
339.
Zelder, O., Klopprogge, C., Schoner, H., Hofner, S., Kroger, B., Kiefer, P. and
Heinzle, E. (2005). WO05059139A2.
Zhang, M., Eddy, C., Deandra, K., Finkelstein, M. and Picataggio, S.
(1995). Metabolic engineering of a pentose metabolism pathway in
ethanologenic Zymomonas mobilis, Science, 267: 240-243.
Zhou, D., Wenxiang, P., Shubiao, J., Xiujuan, S. and Guirong, L. (1991).
Studies on the breeding of highly yield lysine producing strain by
Protoplast fusion, Acta Microbiology, 31: 287-292.
Zupke, C. and Stephanopoulos, G. (1995). Intracellular flux analysis in
hybridomas using mass balances and in vitro 13 C NMR,
Biotechnology and Bioengineering, 45: 292–303.
Zupke, C., and Stephanopoulos, G. (1994). Modeling of isotope
distributions and intracellular fluxes in metabolic networks using
atom mapping matrices, Biotechnology Progress, 10: 489-498.
Zupke, C., and Stephanopoulos, G. (1995). Intracellular flux analysis in
hybridomas using mass balances and in vitro C13 NMR,
Biotechnology and Bioengineering, 45: 292-303.
Zupke, C., Sinskey, A. J., and Stephanopoulos, G. (1995). Intracellular
flux analysis applied to the effect of dissolved oxygen on
hybridomas, Applied Microbiology and Biotechnology, 44: 27-36.
Zupke, C., Tompkins, R., and Yarmush, M. (1997). Numerical
isotopomer analysis: estimation of metabolic activity, Analytical
Biochemistry, 247: 287-293.