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Lecture Presentation
Chapter 20
Organic Chemistry
Sherril Soman
Grand Valley State University
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• Our sense of smell helps us identify food, people, and other organisms, and alerts us to dangers such as polluted air or spoiled food.
• Odorants must be volatile. • However, many volatile substances have no
scent at all. • Most common smells are caused by
organic molecules. • The study of compounds containing carbon
combined with one or more of the elements hydrogen, nitrogen, oxygen, and sulfur, including their properties and their reactions, is known as organic chemistry.
Fragrances and Odors
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What Is Organic Chemistry?
• Organic chemistry is a branch of chemistry that focuses on compounds that contain carbon. – Except CO, CO2, carbonates, and carbides
• Even though organic compounds only contain a few elements, the unique ways carbon atoms can attach together to form molecules leads to millions of different organic compounds.
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• Life as we know it is because of organic chemistry.
• Organic molecules can be very large and complex.
• It is this complexity of large organic molecules that allows the complex functions of the cells to occur.
The Chemistry of Life
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• Organic compounds are easily decomposed into simpler substances by heating, but inorganic substances are not.
• Inorganic compounds were readily synthesized in the lab, but synthesis of organic compounds in the lab is hard.
Differences Between Organic and Inorganic Compounds
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• Organic compounds tend to be molecular. • They are mainly composed of just six
nonmetallic elements. – C, H, O, N, S, and P
• Compounds are found in all three states. – Solids, liquids, and gases – Solids tend to have low melting points
• Solubility in water varies depending on which of the other elements are attached to C and how many there are. – CH3OH is miscible with water; C10H21OH is
insoluble.
What’s Special About Organic Compounds?
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• Carbon atoms can do some unique things that other atoms cannot.
• Carbon can bond to as many as four other atoms.
• Bonds to carbon are very strong and nonreactive.
What’s So Special About Carbon?
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• Carbon atoms can attach together in long chains.
• Carbon atoms can attach together to form rings.
• Carbon atoms can form single, double, or triple bonds.
What’s So Special About Carbon?
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• Hydrocarbons contain only C and H. – Aliphatic or aromatic
• Insoluble in water – No polar bonds to attract water molecules
• Aliphatic hydrocarbons – Saturated or unsaturated aliphatics
• Saturated = alkanes; unsaturated = alkenes or alkynes
– May be chains or rings – Chains may be straight or branched.
• Aromatic hydrocarbons
Hydrocarbons
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• Molecular formulas show the kinds of atoms in the molecule, but they do not show how they are attached.
• Structural formulas show you the attachment pattern in the molecule.
• Models not only show you the attachment pattern, but give you an idea about the shape of the molecule.
Formulas
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• Attached atoms listed in order – Central atom with attached atoms
• Follow normal bonding patterns – Use to determine position of multiple bonds
• () used to indicate more than one identical group attached to same previous central atom – Unless () group is listed first, in which case
attached to next central atom
Condensed Structural Formulas
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Uses of Hydrocarbons
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Uses of Hydrocarbons
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Uses of Hydrocarbons
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Physical Properties of Aliphatic Hydrocarbons
• Boiling points and melting points increase as the size of the molecule increases. – Nonpolar molecules – Main attractive forces are dispersion forces
• Less dense than water • Insoluble in water
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Saturated Hydrocarbons
• A saturated hydrocarbon has all C─C single bonds. – It is saturated with hydrogens.
• Saturated aliphatic hydrocarbons are called alkanes.
• Chain alkanes have the general formula CnH2n+2.
• Ring alkanes have all C─C single bonds, but have fewer hydrogens than a chain with the same number of carbons.
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• Unsaturated hydrocarbons have one or more C═C double bonds or C≡C triple bonds.
• Unsaturated aliphatic hydrocarbons that contain C═C are called alkenes. – The general formula of a monounsaturated chain alkene
is CnH2n. – Remove two more H for each additional double bond.
• Unsaturated aliphatic hydrocarbons that contain C≡C are called alkynes. – The general formula of an alkyne with one triple bond
is CnH2n−2. – Remove four more H for each additional triple bond.
Unsaturated Hydrocarbons
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Aromatic Hydrocarbons
• Aromatic hydrocarbons contain a ring structure that seems to have C═C, but doesn’t behave that way.
• The most prevalent example is benzene. – C6H6
– Other compounds have the benzene ring with other groups substituted for some of the hydrogens.
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• Each angle, and beginning and end, represent a C atom.
• H omitted on C – Included on functional groups
• Multiple bonds indicated – Double line is double bond; triple line is
triple bond
Carbon Skeleton Formulas
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Formulas
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• Isomers are different molecules with the same molecular formula.
• Structural isomers are isomers that have a different pattern of atom attachment. – Also known as constitutional isomers
• Stereoisomers are isomers with the same pattern of atom attachments, but the atoms have a different spatial orientation.
Isomerism
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Butane, BP = 0 °C Isobutane, BP = −12 °C
Structural Isomers of C4H10
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Rotation about a Bond Is Not Isomerism
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• Also know as paraffins • Aliphatic • General formula CnH2n+2 for chains • Very unreactive • Come in chains or/and rings
– CH3 groups at ends of chains, CH2 groups in the middle
• Saturated • Branched or unbranched
Alkanes
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Physical Properties of n–Alkanes
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• Each name consists of three parts – Prefix
• Indicates position, number, and type of branches • Indicates position, number, and type of each
functional group – Parent
• Indicates the length of the longest carbon chain or ring – Suffix
• Indicates the type of hydrocarbon o -ane, -ene, -yne
• Certain functional groups
Naming
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1. Find the longest continuous carbon chain. 2. Number the chain from end closest to a branch.
− If first branches are equal distance, use next substituent
3. Name branches as alkyl groups. − Locate each branch by preceding its name with
the carbon number on the chain. 4. List branches alphabetically.
− Do not count n-, sec-, t-, count iso 5. Use prefix if more than one of same group
present. − “Di-,” “tri-,” “tetra-,” “penta-,” “hexa-” − Do not count in alphabetizing
Naming Alkanes
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Prefixes
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Alkyl Groups
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• Also known as olefins • Aliphatic, unsaturated
– C═C double bonds • Formula for one double bond = CnH2n.
– Subtract 2 H from alkane for each double bond.
• Trigonal shape around C – Flat
• Polyunsaturated = many double bonds
Alkenes
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Alkenes
ethene = ethylene propene = propylene
Produced by ripening fruit
C C H
H H
H
C C H
H C H 3
H
Used to make polyethylene Used to make polypropylene
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• Also known as acetylenes • Aliphatic, unsaturated • C≡C triple bond • Formula for one triple bond = CnH2n − 2.
– Subtract 4 H from alkane for each triple bond.
• Linear shape • Internal alkynes have both triple bond
carbons attached to C. • Terminal alkynes have one carbon
attached to H.
Alkynes
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Alkynes
Used in welding torches
Ethyne = acetylene
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Physical Properties of Alkynes
• Higher boiling points than similar sized alkenes – Similar size = same number of carbons – More pi bond = more polarization = higher boiling point
• Slightly higher densities than similar alkenes • There are no alkyne cis or trans isomers. • Internal alkynes have higher boiling points
than terminal alkynes. – With the same number of C
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• Change suffix on main name from -ane to -ene for base name of alkene, or to -yne for the base name of the alkyne.
• Number chain from end closest to multiple bond.
• Number in front of main name indicates first carbon of multiple bond.
Naming Alkenes and Alkynes
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Reactions of Hydrocarbons
• All hydrocarbons undergo combustion. • Combustion is always exothermic.
– About 90% of U.S. energy generated by combustion
CH3CH2CH3(g) + 5 O2(g) → 3 CO2(g) + 4 H2O(g)
CH2═CHCH2CH3(g) + 6 O2(g) → 4 CO2(g) + 4 H2O(g)
CH≡CCH3(g) + 4 O2(g) → 3 CO2(g) + 2 H2O(g)
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Chemical Energy
• Burning hydrocarbons releases heat and light energy. – Combustion
• Alkane + oxygen → carbon dioxide + water
• Larger alkane, more heat released
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• Substitution – Replace H with a halogen atom. – Initiated by addition of energy in the form of heat
or ultraviolet light • To start breaking bonds
– Generally get multiple products with multiple substitutions
– Methane + chlorine à chloromethane + HCl
Alkane Reactions
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Alkene and Alkyne Reactions: Addition
• Adding a molecule across the multiple bond • Hydrogenation = adding H2
– Converts unsaturated molecule to saturated – Alkene or alkyne + H2 → alkane – Generally requires a catalyst
• Halogenation = adding X2 • Hydrohalogenation = adding HX
– HX is polar. – When adding a polar reagent to a double or triple
bond, the positive part attaches to the carbon with the most H’s.
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Addition Reactions
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Aromatic Hydrocarbons
• Contain benzene ring structure • Even though they are often drawn with
C═C, they do not behave like alkenes.
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Resonance Hybrid • The true structure of benzene is a
resonance hybrid of two structures.
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• (Name of substituent)benzene – Halogen substituent = change ending to “o”
• Or name of a common derivative
Naming Monosubstituted Benzene Derivatives
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Naming Benzene as a Substituent
• When the benzene ring is not the base name, it is called a phenyl group.
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• Number the ring starting at attachment for first substituent, and then move toward the second. – Order substituents alphabetically. – Use “di-” if both substituents are the same.
Naming Disubstituted: Benzene Derivatives
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• Alternatively, use relative position prefix. – Ortho- = 1,2; meta- = 1,3; para- = 1,4
2-chlorotoluene ortho-chlorotoluene
o-chlorotoluene
3-chlorotoluene meta-chlorotoluene
m-chlorotoluene
4-chlorotoluene para-chlorotoluene
p-chlorotoluene
Naming Disubstituted: Benzene Derivatives
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• Other organic compounds are hydrocarbons in which functional groups have been substituted for hydrogens.
• A functional group is a group of atoms that shows a characteristic influence on the properties of the molecule. – Generally, the reactions that a compound will
perform are determined by what functional groups it has.
– Because the kind of hydrocarbon chain is irrelevant to the reactions, it may be indicated by the general symbol.
Functional Groups
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• R—OH • Ethanol = CH3CH2OH
– Grain alcohol = fermentation of sugars in grains
– Alcoholic beverages • Proof number = 2 times percentage of
alcohol – Gasohol
• Isopropyl alcohol = (CH3)2CHOH – 2-propanol – Rubbing alcohol – Poisonous
• Methanol = CH3OH – Wood alcohol = thermolysis of wood – Paint solvent – Poisonous
Alcohols
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• Main chain contains OH. • Number main chain from end closest to OH. • Give base name -ol ending and place
number of C on chain where OH attached in front.
• Name as hydroxy group if higher precedence group present.
Naming Alcohols
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• Contain the carbonyl group – Aldehydes = at least 1 side H – Ketones = both sides R groups
• Many aldehydes and ketones have pleasant tastes and aromas.
• Some are pheromones. • Formaldehyde = H2C=O
– Pungent gas – Formalin = a preservative – Wood smoke, carcinogenic
• Acetone = CH3C(=O)CH3 – Nail-polish remover
Aldehydes and Ketones
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• Main chain contains C═O. – Unless COOH present
• Number main chain from end closest to C═O. • For aldehydes, give base name -al ending.
– Always on C1 • For ketones, give base name -one ending
and place number of C on chain where C═O attached in front.
Naming Aldehydes and Ketones
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• RCOOH • Sour tasting • Weak acids • Citric acid
ü Found in citrus fruit • Ethanoic acid = acetic acid
ü Vinegar • Methanoic acid = formic acid
ü Insect bites and stings
Carboxylic Acids
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• Carboxylic acid group always on end of main chain – Has highest naming precedence of functional
groups • C of group always C1
– Position not indicated in name • Change ending to -oic acid
Naming Carboxylic Acids
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Examples of Naming Carboxylic Acids
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• R—COO—R • Sweet odor • Made by reacting carboxylic acid with an
alcohol RaCOOH + RbOH ⇔ RaCOORb + H2O
Esters
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• Carboxylic acid group always on end of main chain – Unless carboxylic acid group present
• C of ester group on C1 – Position not indicated in name
• Begin name with alkyl group attached to O. • Name main chain with -oate ending.
Naming Esters
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• A condensation reaction is any organic reaction driven by the removal of a small molecule, such as water.
• Esters are made by the condensation reaction between a carboxylic acid and an alcohol. ü The reaction is acid catalyzed.
Condensation Reactions
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• A condensation reaction is any organic reaction driven by the removal of a small molecule, such as water.
Condensation Reactions
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• Acid anhydrides are made by the condensation reaction between to carboxylic acid molecules. ü The reaction is driven by heat.
• A condensation reaction is any organic reaction driven by the removal of a small molecule, such as water.
Condensation Reactions
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Synthesis of Aspirin (Acetylsalicylic Acid)
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Ethers
• Ethers have the general formula ROR.
• The two R groups may be different or identical.
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Ethers
• Diethyl ether is the most common ether.
• It is useful as a laboratory solvent and can dissolve many organic compounds.
• It has a low boiling point.
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• N containing organic molecules • Very bad smelling • Form when proteins decompose • Organic bases • Name alkyl groups attached to the N, then
add -amine to the end.
Amines
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• Many amines are biologically active. – Dopamine – a neurotransmitter – Epinephrine – an adrenal hormone – Pyridoxine – vitamin B6
• Alkaloids are plant products that are alkaline and biologically active. – Toxic – Coniine from hemlock – Cocaine from coca leaves – Nicotine from tobacco leaves – Mescaline from peyote cactus – Morphine from opium poppies
Amines
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• Polymers are very large molecules made by repeated linking together of small molecules. – Monomers
Polymers
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• Natural polymers are polymers found in both the living and nonliving environment.
• Modified natural polymers are natural polymers that have been chemically altered.
• Synthetic polymers are polymers made in a lab from one, two, or three small molecules linked in a repeating pattern. – Plastics, elastomers (rubber), fabrics, adhesives
• Composites are materials made of polymers mixed with various additives. – Additives such as graphite, glass, metallic flakes
Polymers
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• Polysaccharides – polymers made of repeating small sugar molecule units – Cellulose (cotton) – Starch
• Proteins – polymers made of repeating amino acid units • Nucleic acids (DNA) – polymers made of repeating
nucleotide units • Natural latex rubber – polyisoprene • Shellac – a resin secreted by lac bugs • Gutta-percha – a polyisoprene latex from the sap of the
gutta-percha plant – Used to fill space for root canal
• Amber, lignin, pine rosin – resins from trees • Asphalt – polymeric petroleum
Natural Polymers
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• Cellulose acetate – an ester of cellulose and acetic acid – Rayon – Film
• Vulcanized rubber – latex rubber hardened by cross-linking with sulfur
• Nitrocellulose – an ester of cellulose with nitric acid – Gun cotton – Celluloid
• Ping-Pong™ balls
• Casein – a polymer of the protein casein made by treating cow’s milk with acid – Buttons, moldings, adhesives
Modified Natural Polymers
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Polymerization
• Polymerization is the process of linking the monomer units together.
• There are two processes by which polymerization may proceed—addition polymerization and condensation polymerization.
• Monomer units may link head to tail, or head to head, or tail to tail during polymerization. – Head to tail most common – Regular pattern gives stronger attractions between
chains than random arrangements
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• Monomers add to the growing chain in such a manner that all the atoms in the original monomer wind up in the chain. – No other side products formed; no atoms
eliminated
• First monomer must “open” to start reaction. – Done with heat, or the addition of an initiator
• The process is a chain reaction. – Each added unit ready to add another
Addition Polymerization
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Condensation Polymerization
• Monomer units are joined by removing small molecules from the combining units. – Polyesters, polyamides lose water
• No initiator is needed. • The process is a chain reaction. • Each monomer has two reactive ends, so
the chain can grow in two directions.
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• Transparent or translucent • Chemical resistance • Thermal and electrical insulators • Low density • Varying strengths
– Kevlar • Mold or extrude • Elasticity
– Regain original shape if quick stress applied • Foamed • Tend to soften when heated, rather than
quickly melt
Characteristics of Plastics
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Chapter 21
Biochemistry
Lecture Presentation
Sherril Soman
Grand Valley State University
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• Biochemistry is the study of the chemistry of living organisms.
• Much of biochemistry deals with the large, complex molecules necessary for life as we know it.
• However, most of these complex molecules are actually made of smaller, simpler units; they are biopolymers.
• There are four main classes of biopolymers—lipids, proteins, carbohydrates, and nucleic acids.
Biochemistry
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Lipids
• Chemicals of the cell that are insoluble in water, but soluble in nonpolar solvents.
• Fatty acids, fats, oils, phospholipids, glycolipids, some vitamins, steroids, and waxes
• Structural components of cell membrane – Because they don’t dissolve in water
• Long-term energy storage • Insulation
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• Carboxylic acid (head) with a very long hydrocarbon side chain (tail).
• Saturated fatty acids contain no C═C double bonds in the hydrocarbon side chain.
• Unsaturated fatty acids have C═C double bonds. – Monounsaturated have 1 C═C. – Polyunsaturated have more than 1 C═C.
Fatty Acids
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Myristic acid
Oleic acid – C18H34O2 a monounsaturated fatty acid
Fatty Acids
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• Larger fatty acid = higher melting point • Double bonds decrease melting point
– More DB = lower MP • Saturated = no DB • Monounsaturated = 1 DB • Polyunsaturated = many DB
Structure and Melting Point
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• Because fatty acids are largely nonpolar, the main attractive forces are dispersion forces.
• Larger size = more electrons = larger dipole = stronger attractions = higher melting point
• More straight = more surface contact = stronger attractions = higher melting point
Effect on Melting Point
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Triglycerides
• Triglycerides differ in the length of the fatty acid side chains and degree of unsaturation. – Side chains range from 12 to 20 C. – Most natural triglycerides have different fatty acid chains
in the triglyceride, simple triglycerides have three identical chains.
• Saturated fat = all saturated fatty acid chains – Warm-blooded animal fat – Solids
• Unsaturated fats = some unsaturated fatty acid chains – Cold-blooded animal fat or vegetable oils – Liquids
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• Phospholipids are esters of glycerol in which one of the OH groups of glycerol esterifies with phosphate. – Other two OH are esterified with fatty acids
• Phospholipids have a hydrophilic head due to phosphate group, and a hydrophobic tail from the fatty acid hydrocarbon chain.
• Part of lipid bilayer found in animal cell membranes
Phospholipids
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Lipid Bilayer
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• Characterized by four linked carbon rings • Mostly hydrocarbon-like
– Dissolve in animal fat
• Mostly have hormonal effects • Serum cholesterol levels linked to
heart disease and stroke – Levels depend on diet, exercise, emotional stress,
genetics, etc.
• Cholesterol synthesized in the liver from saturated fats.
Steroids
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• Carbon, hydrogen, and oxygen • Ratio of H:O = 2:1
– Same as in water • Polyhydroxycarbonyls have many
OH and one C═O. – Aldose when C═O is aldehyde – Ketose when C═O is ketone
• The many polar groups make simple carbohydrates soluble in water. – Blood transport
• Also known as sugars, starches, cellulose, dextrins, and gums
Carbohydrates
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• Monosaccharides cannot be broken down into simpler carbohydrates. – Triose, tetrose, pentose, hexose
• Disaccharides are two monosaccharides attached by a glycosidic link. – Lose H from one and OH from other
• Polysaccharides are three or more monosaccharides linked into complex chains. – Starch and cellulose are polysaccharides
of glucose.
Classification of Carbohydrates
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Polysaccharides
• Also known as complex carbohydrates • Polymer of monosaccharide units bonded
together in a chain • The glycosidic link between units may be either α or β.– In α, the rings are all oriented the same direction. – In β, the rings alternate orientation.
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• Involved in practically all facets of cell function • Polymers of amino acids
Proteins
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• NH2 group on carbon adjacent to COOH - α-amino acids
• About 20 amino acids found in proteins – 10 synthesized by humans, 10 “essential”
• Each amino acid has a three-letter abbreviation. – Glycine = Gly
• High melting points – Generally decompose at temp > 200 °C
• Good solubility in water • Less acidic than most carboxylic acids and less basic
than most amines
Amino Acids
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Basic Structure of Amino Acids
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Basic Structure of Amino Acids
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• Building blocks of proteins • Main difference between amino acids is the
side chain – R group
• Some R groups are polar, while others are nonpolar. • Some polar R groups are acidic, while others
are basic. • Some R groups contain O, others contain N, and
others contain S. • Some R groups are rings, while others are chains.
Amino Acids
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• Carry genetic information • DNA molar mass = 6 to 16 million amu • RNA molar mass = 20 K to 40 K amu • Made of nucleotides
– Phosphoric acid unit – 5-carbon sugar – Cyclic amine (base)
• Nucleotides are joined by phosphate linkages.
Nucleic Acids
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• Deoxyribonucleic acid • Sugar is deoxyribose. • DNA is made up of the following amine bases:
– Adenine (A) – Guanine (G) – Cytosine (C) – Thymine (T)
• Two DNA strands wound together in double helix • Each of the 10 trillion cells in the body has the
entire DNA structure.
DNA
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• Ribonucleic acid • Sugar is ribose. • RNA is made of up of the following amine bases:
– Adenine (A) – Guanine (G) – Cytosine (C) – Uracil (U)
• Single strands wound in helix
RNA
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• DNA made of two strands linked together by H-bonds between bases
• Strands are antiparallel – One runs 3'→ 5', while other runs 5'→ 3'.
• Bases are complementary and directed to the interior of the helix. – A pairs with T, and C with G.
DNA Structure
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• Base pairing generates the helical structure. • In DNA, the complementary bases hold strands
together by H-bonding. – Allow replication of strand
Base Pairing
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DNA Replication
• When the DNA is to be replicated, the region to be replicated uncoils.
• This H-bond between the base pairs is broken, separating the two strands.
• With the aid of enzymes, new strands of DNA are constructed by linking the complementary nucleotides and the original strand together.
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DNA Replication
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• Transcription → translation • In the nucleus, the DNA strand at the gene
separates and a complementary copy of the gene is made in RNA. – Messenger RNA = mRNA
• The mRNA travels into the cytoplasm where it links with a ribosome.
• At the ribosome, each codon on the RNA codes for a single amino acid, and these are joined together to form the polypeptide chain.
Protein Synthesis