Download - Anti Infective Drugs
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Anti-infective Drugs
Jan Bazner-Chandler
MSN, CNS, RN, CPNP
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Bacteria
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Bacteria
Gram-positive bacterium has a thick layer of peptioglycan.
Gram-negative bacterium has a thin peptioglycan layer and an outer membrane.
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Common Bacterial Pathogens
Gram positive Staphylococcus aureus Streptocci Enterococci
Gram negative Escherichia coli or E-coli Klebsiella Proteus Pseudomonas
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Empiric Therapy
Administration of antibiotics based on the practitioner’s judgment of the pathogens most likely to be causing the infection; it involves the presumptive treatment of an infection to avoid treatment delay before specific cuture information has been obtained.
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Prophylactic Antibiotic Therapy Antibiotics taken before anticipated exposure
to an infectious organism in an effort to prevent the development of infection. IV antibiotics given prior to surgery
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Superinfection
An infection occurring during antimicrobial treatment for another infection, resulting from overgrowth of an organism not susceptible to the antibiotic used.
A secondary infection that occurs due weakening of the patients immune system by the first infection.
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Examples of Superinfections
Fungal or yeast infection Diarrhea due to diminished normal flora of
the gastrointestinal tract.
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Laboratory Tests
Gram stain – microscopic identification of organism
Culture – identifies causative agent and susceptibility to specific antibiotics
Serology – titers or antibodies measured CBC – looking at WBC
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Cultures
Throat Wound Urine Sputum Blood
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Clinical Pearl
Always collect culture: urine, sputum, wound drainage, or blood prior to starting antibiotic therapy.
If technician is drawing blood make sure it has been done before starting antibiotics.
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Antimicrobials
Drugs used to prevent or treat infection caused by pathogens
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Two Classifications
Bactericidal drugs kill bacteria directly. Bacteriostatic drugs prevent bacteria from
dividing or inhibits their growth.
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Infectious Disease
• Infections disease involves the presence of pathogen plus clinical signs and symptoms indicating infection.
• Microorganisms spread by direct contact with infected person or contaminated hands, food, water, or objects.
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Opportunistic Infections
Severe burns Cancer HIV Indwelling IV catheter or urinary catheter Corticosteroid therapy Fungal or viral infections
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Two Types of Bacteria
Aerobic – grow and live in presence of oxygen Staph & Strep
Anaerobic – cannot grow in presence of oxygen Deep wounds Characterized by abscess formation, foul-smelling
pus and tissue destruction
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Community-Acquired Infection Less severe and easier to treat, although
drug resistant strains are increasing Remember Staph is everywhere – it is normal
flora on skin and in the upper respiratory tract
MRSA: methicillin-resistant-Staphylococcus aureus
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Nosocomial Infections
More severe and difficult to manage because they often result from drug-resistant microorganisms and occur in clients whose resistance is impaired Pseudomonas Proteus
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Bacterial Resistance
Bacteria develop the ability to produce substances which block the action of antibiotics or change their target or ability to penetrate the cells.
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What causes resistance?
Widespread use of antimicrobial drug Interrupted or inadequate antimicrobial
treatment of infection Type of bacteria – gram-negative strains
have higher rates of resistance Re-occurring infections Condition of the host Location – critical care areas
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Client History / Assessment
Allergies Previous drug reactions Baseline renal and liver function Review culture reports for appropriate
antibacterial drug choice Patient response to antibiotics therapy
Are they getting better? Any side effects?
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Antibiotics
Sulfonamides Penicillins Cephalosporins Macrolides Fluoroquinolones Aminoglycosides Tetracyclines
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Sulfonamides
Action: inhibit the growth of bacteria (bacteriostatic antibiotic) by inhibiting the growth of susceptible bacteria by preventing bacterial synthesis of folic acid.
Usually used in combination drugs. Trimethoprim / sulfamethoxazole: Trade name
Bactrim, Septra, TMP/SMX
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Indications
Broad spectrum: can be used against gram negative and gram positive organisms
Very useful in treating kidney infections since they achieve a high concentration in the kidneys.
Susceptible organisms: Enterobacter, E.Coli, Klebsiella, Proteus
Problem: organisms becoming more resistant
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Specific Use of Sulfa Drugs
HIV patients with pneumocystis carinii’ May be given Bactrim or Septra
prophylactically.
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Contraindications
Drug allergy to sulfa Use of thiazide and loop diuretics Pregnant women Infants younger than 2 months of age
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Adverse Effects
Most common is cutaneous reactions – can occur weeks after therapy started. Erythema multiforme (Stevens Johnson
Syndrome) Toxic epidermal necrolysis
Photosensitivity reactions: exposure to sunlight can result in severe sunburn
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B-Lactam Antibiotics
Includes 4 major drug classifications penicillins cephalosporins carbapenes monobactams
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Penicillin
Derived from mold fungus
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Penicillin
First generation IM or IV Newer penicillins have been developed that
increase gastric acid stability of penicillin Good drug since it enters most bodily fluids:
joint, pleural, and pericardial. Not effective against intraocular (eye) or
cerebral spinal fluid infection (CSF)
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Penicillin
Bactericidal action against sensitive bacteria Action: binds to bacterial wall, resulting in cell
death
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Susceptible Bacteria
Gram-positive organisms Streptococcus Enterococcus Staphylococcus
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Adverse Reactions
Most common reaction is GI (diarrhea) when administered orally.
Urticaria, pruritus, and angioedema Severe reaction: Steven’s Johns Syndrome Note: when giving IV or IM observe for ½ to 1
hour after giving for adverse reactions.
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Combination Penicillin / B-lactamases Unasyn Augmentin Timentin Zosyn
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Ampicillin – Synthetic Penicillin Broad spectrum effective against several
gram-positive and gram-negative bacteria E-coli, proteus, Salmonella, Shigella Not effective against staphylococci on
gonococci Bronchitis, sinusitis, and otitis media
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Ampicillin
Bactericidal action – spectrum is broader than penicillin
Binds to bacterial wall resulting in cell death
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Nursing Implications
Same as penicillin Ask client about oral contraceptive use – drug
may cause transient decrease in effectiveness
Advise to use additional BC – barrier protection during antibiotic therapy
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Amoxicillin
Oral equivalent of Ampicillin Readily absorbed and reaches therapeutic
levels rapidly Drug of choice in prevention of bacterial
endocarditis Clients with total knee or hip replacement, heart
valve replacement need to take prior to any dental work, endoscopy exams
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Dosing for Amoxicillin
Adults: 250 to 500 mg q8h Infants and children less than 20 kg:
20 – 40 mg / kg / day divided into doses q 8 hours
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Cephalosporins
• Widely used drug derived from fungus• Used against gram–negative bacteria• Widely absorbed and distributed in most
bodily fluids – placenta and breast milk
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Cephalosporin
First generation Cephalosporin drugs do not reach therapeutic levels in CSF (cerebral spinal fluid) but 2nd, and 3rd generation drugs do – especially important in treating meningitis
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First Generation Cephalosporins
Bactericidal action – binds to bacterial cell wall, causing cell death Keflex (PO) still used extensively in treatment of
skin infections Ancef – often ordered preoperatively
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First Generation Cephalosporins
Bactericidal action – binds to bacterial cell wall, causing cell death Keflex (PO) still used extensively in treatment of
skin infections Ancef – often ordered preoperatively
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Keflex
First generation cephalosporin Action: binds to bacterial cell wall membrane,
causing cell death Therapeutic effect: bactericidal action against
susceptible bacteria Active against many gram-positive cocci –
step and staph
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Client teaching
May be taken with or without food but food may minimize the GI irritation
Distribution: may cross placenta or enter breast milk in low concentrations.
Excreted entirely by the kidneys.
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Keflex Dosing
Adults: 250 – 500 mg q 6 hours Children: 25 – 50 mg / kg / day in divided
doses q 6 h
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Cefazolin or Ancef
Cefazolin – first generation cephalosporin Well absorbed following IM or IV
administration Crosses to placenta and breast milk in small
concentrations Minimal CSF penetration Excreted by kidneys
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Ancef Dosing
IV Used for UTI, bone and skin infections,
endocarditis Not suitable for treatment of meningitis Perioperative prophylaxis
1 gram within 60 minutes of incision Post operatively every 8 hours for 24 hours (3 doses)
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Second-Generation Cephalosporins More active against some gram-negative
organisms and anaerobic organisms than the first generation drugs.
May be effective in infections resistant to other antibiotics
Penetration into CSF is poor but adequate to be used in meningitis
Action: bactericidal – binds to cell wall
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Third Generation Cephalosporin Drugs Similar to the second generation but has
increased activity against gram-negative pathogens even for drug resistant pathogens.
CSF penetration is better than the first two generation cephalosporin drugs.
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Drug / Drug Allergies
If a client is allergic to penicillin there is a 1 to 18% chance they will be allergic to cephalosporin drugs.
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Carbapenems
Has very broad antibacterial action Are often used for complicated body cavity
and connective tissue infections in the hospitalized patient. imipenem-cilastatin (Primaxin) meropenen (Merrem): only drug in this class used
in the treatment of bacterial meningitis.
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Macrolides
Macrolides first developed in the 1950s with the drug: erythromycin. Four main drugs
azithromycin * Zithromax Clarithromcin * Biazin dirithromycin erythromycin
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Macrolides
Two of the new drugs in the macrolide classification: azithromycin and clarithromycin have longer duration and improved resistance to acid degradation in the stomach. Dosing is less frequent GI effects decreased Better absorption than erythromycin
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Macrolides
Action: work by inhibiting protein synthesis in susceptible bacteria.
Contraindications: drug allergy Adverse effect: two new drugs have lower GI
effects and are used in patients allergic to penicillin / cephalosporin drugs.
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Ketaloids
Only one drug in this drug classification Generic: telithromycin Trade: Ketek Available for oral use only. Better acid stability and antibacterial
coverage than macrolides.
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Tetracyclines
Action: binds to divalent (Ca2 + mg2) and Al3 mettalic ions to form insoluble complexes.
Why do you need to know this? When given with milk, antacids or iron there is a
reduction in oral absorption. Contraindicated in children under 8 years of age
because it can result in tooth discoloration.
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Tetracyclines
When used? Syphilis and Lyme disease
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Antibiotics Used to Treat Serious Infections IM or IV administration Have more toxic side effects Blood levels may need to be monitored to
determine therapeutic versus toxic levels of mediation in the blood.
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Serious Adverse Effects
Nephrotoxicity: Toxicity to kidneys, often drug induced and manifesting in compromised kidney function.
Ototoxicity: Toxicity to the ears, often drug-induced and manifested by varying degrees of hearing loss than is likely to be permanent.
Pseudomembranous colitis: a necrotizing, inflammatory bowel condition associated with antibiotic therapy.
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Aminoglycosides
Pharmacologic classification: Bactericidal drugs
Therapeutic classification: anti-infective Action: inhibits protein synthesis at the level
of the 30s ribosome Work primarily on dosing due to
concentration dependent killing of bacteria
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Concentration Dependent
A property of some antibiotics, especially aminoglycosides and vancomycin, of achieving a relatively, high plasma drug concentration, results in the most effective bacterial kill.
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Blood Plasma Levels
Peak levels: refers to amount of drug present in blood plasma within 15 to 30 minutes of IV drug administration 30 to 90 minutes of IM drug administration
Trough levels: refers to lowest level of drug present in the blood plasma. Since the drugs can cause severe adverse effects the
excretion of the drug needs to be monitored. Blood drawn just before the next dose given.
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Adverse Effects Aminoglycosides Nephrotoxicity occurs in 5 to 25% and
ototoxicity (damage to VIII cranial nerve) occurs in 3 to 14%.
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Aminoglycosides
gentamicin (Garamycin) tobramycin (Nobcin, TOBI) neomycin (Neo-Fradin)
used to irrigate bowel before major bowel surgery Topical applied to eye and skin infections
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Floroquinolones
Action: destroys bacteria by altering their DNA.
Two most common drugs: ciproflxcin (Cipro) clindamycin (Cleocin)
Used in treatment of chronic infections or deep (anaerobic) abdominal infections and MRSA.
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Major Adverse Side Effect
Clindamycin or Cleocin can cause pseudomembranous colitis
Signs and symptoms: abdominal pain and diarrhea
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MRSA Infections
MRSA infection is caused by Staphylococcus aureus bacteria — often called "staph." MRSA stands for methicillin-resistant Staphylococcus aureus. It's a strain of staph that's resistant to the broad-spectrum antibiotics commonly used to treat it. MRSA can be fatal.
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Vancomycin
Action: destroys bacteria by binding to the bacterial cell wall, producing immediate inhibition of cell wall synthesis and death.
Most common drug used in MRSA infections.
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Adverse Effect
Red man syndrome has often been associated with rapid infusion of the first dose of the drug and was initially attributed to impurities found in vancomycin preparations. Even after improvement in vancomycin's purity, however, reports of the syndrome persist.
Flushing on upper chest, neck and face Intervention: slow the infusion rate.
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Anti-viral Drugs
Kill or suppress viruses by either destroying virons or inhibiting their ability to replicate.
Does not irradiate the virus but helps the immune system to eliminate the virus.
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Drugs to help with the Flu
Tamiflu and Relenza Uses: active against influenza virus types A
and B. Shown to reduce the duration of influenza
infection by a few days.
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Herpes Zoster
Herpes simplex virus type 1: cold sore Herpes simplex virus type 2: genital herpes Human herpesvirus type 3: chicken pox or
shingles Human herpesvirus type 4: Espstein Barr
Virus Human herpesvirus type 5: CMV or
cytomegalovirus
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Herpes Drugs
Generic: acyclovir Trade: Zovirax Action: interferes with DNA synthesis. Therapeutic effects: Inhibition of viral
replication, decreased viral shedding and reduced time for healing of lesions.
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acyclovir
Comes in topical, po and IV preparations Should be started within 24 hours of
outbreak.