Acetaminophen

• 10–20% opioid-sparing effect1

• Synergistic with oral opioids2

• Additive effect greater than NSAIDs alone3

• IV preparation: Quick onset4

• Good side-effect profile; RID: 1–2%

1. Remy, Br J Anaesth 2005;94:505–13

2. Chandrasekharan, Proc Natl Acad Sci 2002;99:13926–31

3. Ong, Anesth Analg 2010;110:1170–9

4. Alhashemi, Can J Anaesth 2006;53:1200–6 RID, relative infant dose