ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Scott C. Denne, MDAssociate Director, Indiana CTSI
April 25, 2011
Plenary Session II: “Research Highlights of the Year”
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Research Inventions and Scientific Innovation (RISC) Grants
Pilot program supports research that leads to IP generation
K Basic Science Scholar AwardsCareer development supports PhD basic scientists doing translational research
Project Development Team Pilot Funding
Multidisciplinary team supports development of preliminary data for external grant submissions
Unique Pilot Funding Programs of the Indiana CTSI
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Project Development Teams (PDTs)
•Multidisciplinary teams serve as “one stop shops” by providing investigators access to protocol/project development; pilot funding; biostatistics; IRB/regulatory and nursing support
•Helps investigators develop ideas/hypotheses into well-designed translational projects
•Facilitates collaboration with other investigators
•Provides access to other CTSI resources
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Translational Sciences Research
Officer Clinical Sciences
(T1, T2, T3)
Imaging Sciences
(T1, T2, T3)
Pediatric Sciences
(T1, T2, T3)
Beh. & Pop. Sci
(T2, T3, T4)
Purdue(T1, T2, T3,
T4)
Notre Dame (T1, T2)
PreClinical Sciences
(T1)
Design and Biostatistics
Program
Regulatory Knowledge
Support Program
Research Recruitment
Research Education,
Training and Career
Development
Community and Health
Engagement Program
Indiana Biobank
Clinical Research
Center
Tracking and Evaluation
Indiana University
Research & Technology Corporation
CTSI HUBPDT Web Page
Investigator
Fill out PDT assistance request form
Assign to PDT(s)
Translational Technologies
and Resources Program
Other CTSI Programs with representatives on PDTs
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
PDT projects - portfolio by stage
PreclinicalSciences
PediatricSciences
BP Sciences
Purdue
Imaging
BENCH Basic Science Research
Preclinical StudiesAnimal Research
Clinical Sciences
Notre Dame
BEDSIDE
Human Clinical Research
Controlled Observational
StudiesPhase 3 Clinical
Trials
PRACTICE Clinical PracticeDelivery of CareIdentification of
New Clinical Questions and
Gaps in Care
T1Case Series
Phase 1 and 2Clinical Trials
T2Guideline Development
Meta-analysesSystematic ReviewsT3
Dissemination & Implementation ResearchHealth Systems Redesign
Applied Health ITProof of Model DrugConcept Dev Dev
4 1 3 5 6 7 8 212 9 1011 131415
16171819 20 21 2223 2425
26 2728 29 30 31 32 33 34 35 36 37 38 39 40 41 42 4344 4546 47 484950
5152
5354
55 56 57 58 59 60 61 6263 64 65 6667 6869 7071 7273 74 75 76 77 78 7981 82
83 84 85 86 87 88 89 90 91 92 93 94 95 9697 98
99100 101102 103 104
105106
107108
109 110 111112113 114 115 116117 118 119 120 121122
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148 149 150
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80
186
203 204 205 206207
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213214 215
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TRIP
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