Nature 517, 455–459 (22 January 2015)
Kim LewisNortheastern University
. Kaeberlein et al. Science 2002;296:1127-1129
1 g soil from Maine
+
One cell/20 μl of mediumSMS media
Seawater
Appl. Environ. Microbiol. April 2010 vol. 76 no. 8
Soil
Appl. Environ. Microbiol. April 2010 vol. 76 no. 8
B
1 transfer, 26%
2 transfer, 13%
3 transfer, 22%
4 transfer , 13%
>4 transfer, 17%
unsustinable, 9%
Domestication
Front. Microbiol., 08 July 2014
Eleftheria terrae
Structure of teixobactin
Non-ribosomal peptide synthetase
Bacteriacidal activity against S. aureus
Fig. 5. Bacterial cell surface charge is regulated during growth.
Miki Matsuo et al. Microbiology 2011;157:1786-1797
©2011 by Society for General Microbiology
Late exponential activity against VISA
Bactericidal activity against VISA
Low dose(4×MIC) for 27 days
Teixobactin作用機轉示意圖圖/駱宛琳
結論
新思考方式突破過去困境
微生物世界仍有許多未知
人體實驗結果仍待觀察