1
Figure S1 Sugimoto et al.
59.0616 m/z
***
******
*** *** ***
HC OC BC PC PD0.00
0.02
0.04
0.06
0.08
0.10
Rel
ativ
e A
rea
214.4440 m/z
*****
HC OC BC PC PD0.00
0.05
0.10
0.15
Rel
ativ
e A
rea
90.0553 m/z
****
****
HC OC BC PC PD0.00
0.05
0.10
0.15
Rel
ativ
e A
rea
131.1174 m/z
*
*****
**
HC OC BC PC PD0.0
0.1
0.2
0.3
0.4
Rel
ativ
e A
rea
104.0706 m/z
******
HC OC BC PC PD0.00
0.05
0.10
0.15
Rel
ativ
e A
rea
**
Cadaverine
****
*
HC OC BC PC PD0.0
0.5
1.0
1.5
2.0
Rel
ativ
e A
rea
118.0864 m/z, 10.05 min.
*
HC OC BC PC PD0
5
10
15
Rel
ativ
e A
rea
409.2312 m/z
*
******
*
HC OC BC PC PD0.00
0.05
0.10
0.15
0.20
Rel
ativ
e A
rea
437.7442 m/z
**
HC OC BC PC PD0.0
0.2
0.4
0.6
Rel
ativ
e A
rea
215.1269 m/z
*
*
HC OC BC PC PD0.0
0.1
0.2
0.3
Rel
ativ
e A
rea
alpha-Aminobutyric acid
HC OC BC PC PD0.00
0.05
0.10
0.15
0.20
0.25
Rel
ativ
e A
rea
**
****
***
Putrescine
HC OC BC PC PD0.00
0.05
0.10
0.15
Rel
ativ
e A
rea
*
*****
*
Methylimidazoleacetic acid
HC OC BC PC PD0.0
0.1
0.2
0.3
0.4
0.5
Rel
ativ
e A
rea
***
Trimethylamine
HC OC BC PC PD0.0
0.5
1.0
1.5R
elat
ive
Are
a
******
* **
145.1332 m/z
HC OC BC PC PD0.0
0.2
0.4
0.6
0.8
1.0
Rel
ativ
e A
rea
***
*
2
Figure S1 (Continued) Sugimoto et al.
Piperidine
HC OC BC PC PD0
2
4
6
Rel
ativ
e A
rea
*
**
Piperideine
HC OC BC PC PD0.00
0.02
0.04
0.06
0.08
0.10
Rel
ativ
e A
rea
***
*
*
*** ***** *** **
72.0813 m/z
HC OC BC PC PD0.00
0.05
0.10
0.15
0.20
Rel
ativ
e A
rea
*******
***
***
120.0801 m/z
HC OC BC PC PD0.00
0.05
0.10
0.15
0.20
0.25
Rel
ativ
e A
rea
******* *** ****
***
Pyrroline hydroxycarboxylic acid
HC OC BC PC PD0.0
0.2
0.4
0.6
0.8
Rel
ativ
e A
rea
**
*** *****
BetaineHC OC BC PC PD
0.00
0.05
0.10
0.15
Rel
ativ
e A
rea
**
70.0655 m/z
HC OC BC PC PD0.0
0.5
1.0
1.5
Rel
ativ
e A
rea
*
139.0500 m/z
HC OC BC PC PD0.00
0.02
0.04
0.06
0.08
Rel
ativ
e A
rea
*****
*
Phenylalanine
HC OC BC PC PD0.0
0.5
1.0
1.5
Rel
ativ
e A
rea
*
****
***
** *
Tyrosine
HC OC BC PC PD0.0
0.2
0.4
0.6
0.8
Rel
ativ
e A
rea
*
*****
**
Proline
HC OC BC PC PD0
2
4
6
8
Rel
ativ
e A
rea
***** *
Ornithine
HC OC BC PC PD0.0
0.2
0.4
0.6
0.8
Rel
ativ
e A
rea
**
Lysine
HC OC BC PC PD0.0
0.5
1.0
1.5
Rel
ativ
e A
rea
******** *
Glycine
HC OC BC PC PD0
1
2
3
Rel
ativ
e A
rea
***
*
367.1977 m/z
HC OC BC PC PD0.00
0.05
0.10
0.15
0.20
Rel
ativ
e A
rea
*
3
Figure S1 (Continued) Sugimoto et al.
Pro-Gly-Pro or Pro-Pro-Gly
HC OC BC PC PD0.00
0.05
0.10
0.15
Rel
ativ
e A
rea
**
173.0919 m/z
HC OC BC PC PD0.0
0.1
0.2
0.3
0.4
Rel
ativ
e A
rea
**
Ethanolamine
HC OC BC PC PD0.0
0.1
0.2
0.3
0.4
0.5
Rel
ativ
e A
rea
******
*****
Burimamide
HC OC BC PC PD0.0
0.2
0.4
0.6
0.8
Rel
ativ
e A
rea
*
gamma-Aminobutyric acid
HC OC BC PC PD0.00
0.02
0.04
0.06
0.08
0.10
Rel
ativ
e A
rea
********
**
Citrulline
HC OC BC PC PD0.0
0.5
1.0
1.5
Rel
ativ
e A
rea
beta-Alanine
HC OC BC PC PD0.00
0.05
0.10
0.15
0.20
Rel
ativ
e A
rea
****
**
HC OC BC PC PD0.0
0.2
0.4
0.6
Rel
ativ
e A
rea
Aspartic acid
*****
**** **
Serine
HC OC BC PC PD0.0
0.2
0.4
0.6
0.8
Rel
ativ
e A
rea
******
******
Glutamine
HC OC BC PC PD0.0
0.5
1.0
1.5
2.0
Rel
ativ
e A
rea
****** ***
Hypoxanthine
HC OC BC PC PD0.00
0.05
0.10
0.15
0.20
0.25
Rel
ativ
e A
rea
*****
*** **
Choline
HC OC BC PC PD0.0
0.5
1.0
1.5
2.0
2.5
Rel
ativ
e A
rea
******* **
118.0863 m/z, 13.42 min.
HC OC BC PC PD0.0
0.2
0.4
0.6
0.8
1.0
Rel
ativ
e A
rea
**** *** ***
*
*****
*
Glycerophosphocholine
HC OC BC PC PD0.00
0.02
0.04
0.06
0.08
Rel
ativ
e A
rea
173.0285 m/z
HC OC BC PC PD0.00
0.02
0.04
0.06
Rel
ativ
e A
rea
*** *
*
*****
*
*
4
Figure S1 (Continued) Sugimoto et al.
288.9691 m/z
HC OC BC PC PD0.00
0.05
0.10
0.15R
elat
ive
Are
a
* *** ****
