-
..
. ..
-
-
-
Death Receptors(e.g. Fas, TNF-R1)RadiationDrugs/Chemicals/DiseasesCell surfaceAPOPTOSISNucleusDegradation of DNA andother death substratesGene activation and repressionCaspase 3Caspase 6Caspase 7Caspase 8activationMitochondriaROS(Oxidative stress)NF-kBP53AP-1BaxBcl-2MPT, Ca2+Release of AIF, Cyto C, Apaf-1, Caspases-2,-3,-9 into cytosol
-
THE SCHEME OF mPTP OPENING
-
ISCHEMIA-REPERFUSION OF ISOLATED HEART LVP mm HgdP/dt mm Hg/ss
-
mm Hgmm Hg/s01000-200020001000smm Hgmm Hg/s0100-20000200001000sEffect of mitochondrial permeability transition pore activators phenilarsine oxide and antimycin A on isolated heart function0
Phenilarsine oxide Antimycin A (10-5M) (10-6M)
-
Absorption spectra of coronary effluents collected during various periods of reperfusion controlpre-treatment withcyclosporin A (10-6 M)Reperfusion:1 - 1st-min, 2 - 2th-min3 - 5th-min, 4 - 40th-min5 - before ischemia 1 - 1st-min, 2 1st-min with CsA pre-treatment3 - before ischemia
-
Correlation between changes in heart function, oxygen cost of myocardial work and the level of absorbance peaksLVPdP/dtmaxCFOxygen cost of myocardial work
1 - reperfusion 40 min; 2 - reperfusion under the pre-treatment with Trolox (10-6 M);3 - reperfusion under the pre-treatment with cyclosporin A 10-6 M);4 - administration of antimycin A (10-6 M)
-
mm Hgmm Hgs3000Pre-treatment with trolox decreased postreperfusion heart injury and absorption spectra of coronary effluentsControlTroloxLVPabsorption spectra
-
Changes in contractile parameters and oxygen cost of myocardial work after 40 min reperfusionLVPCFdP/dtmaxdP/dtmin1 - control, 2 - cyclosporin A 10-6 M, 3 - Trolox 10-6 M (10 min before ischemia)
Oxygen cost of myocardial work
-
Pre-treatment with melatonin decreased postreperfusion heart injurycontrolmelatoninLVP, mm Hg
-
Effect of hypoxic precondition on myocardial contraction in guinea pig heartscontrolpreconditioning 15 min X 5, 7 days
-
NO- ,
-
Na , 8 40
-
.. ..
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1.1
0
25
50
75
100
125
[mm Hg]
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1.1
1.2
1.3
1.4
1.5
0
25
50
75
100
125
150
175
[mm Hg]
-
20 . 5 .. .. 2+ , .
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
100.0.0
1.1
1.2
1.3
1.4
1.5
0
50
100
150
[mm Hg]
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1.1
1.2
0
50
100
150
[mm Hg]
8
0.1120.06350.0140.00611055550.0570.009
1
dP/dt maxdP/dt min
486745671830.112
5.67.26.58.39.10.014
l-NMMA66826880129
5.716.46.83.320.6
626469661580.051
6.90.91.37.417.10.012
1
000
000
000
000
000
l-NMMA
%
2
0005.65.76.9
0007.216.40.9
0006.56.81.3
0008.33.37.4
l-NMMA
%
3
0009.120.617.1
l-NMMA
%
Sheet4
000.0140.012
0.1120.06350.0140.00611055550.0570.009
48.77563.044330579462.45548821515.77472170023.01406653244.0362406744
65.837561.223666546960.60748646897.31558848095.77252619075.4171769358
45.4966.119885837169.5455255726.7170776494.75837814515.3106290876
86.7625104.0694793063122.66648894953.49514650738.2228601413.8703813367
91.497.150072806899.0517075614.41.05179262911.604938067
67.85769.664822880669.07719260558.2852.56231214693.4523148535
%
196.25113.2324394869127.458990926395.026207504710.275146908
t-Test: Paired Two Sample for Means
,%dP/dTmax,%dP/dTmin,%,%..,%dP/dTmax,%dP/dTmin,%,%..
62617012399691278189881931055688
Mean153.4075995132.97766262545514231065627511910081109
Variance466.9944789121411.4753301056514657919470144
Observations88dP/dTmaxdP/dTmin..594355969571149
Pearson Correlation0.860833950263616610497701137273831489780123
Hypothesized Mean Difference0365813546504615410057151
df758647210310675
t Stat5.1941347795675879779663
P(T
-
2+ % - 1 - 2 - 31
2
3
6
48.77563.044330579462.45548821515.77472170023.01406653244.0362406744
65.837561.223666546960.60748646897.31558848095.77252619075.4171769358
45.4966.119885837169.5455255726.7170776494.75837814515.3106290876
86.7625104.0694793063122.66648894953.49514650738.2228601413.8703813367
91.497.150072806899.0517075614.41.05179262911.604938067
67.85769.664822880669.07719260558.2852.56231214693.4523148535
%
40 .
1
dP/dt maxdP/dt min
486745671830.112
5.67.26.58.39.10.014
l-NMMA66826880129
5.716.46.83.320.6
626469661580.051
6.90.91.37.417.10.012
1
000
000
000
000
000
l-NMMA
%
2
0005.65.76.9
0007.216.40.9
0006.56.81.3
0008.33.37.4
l-NMMA
%
3
0009.120.617.1
l-NMMA
%
Sheet4
000.0140.012
0.1120.06350.0140.00611055550.0570.009
48.77563.044330579462.45548821515.77472170023.01406653244.0362406744
65.837561.223666546960.60748646897.31558848095.77252619075.4171769358
45.4966.119885837169.5455255726.7170776494.75837814515.3106290876
86.7625104.0694793063122.66648894953.49514650738.2228601413.8703813367
91.497.150072806899.0517075614.41.05179262911.604938067
67.85769.664822880669.07719260558.2852.56231214693.4523148535
%
196.25113.2324394869127.458990926395.026207504710.275146908
t-Test: Paired Two Sample for Means
,%dP/dTmax,%dP/dTmin,%,%..,%dP/dTmax,%dP/dTmin,%,%..
62617012399691278189881931055688
Mean153.4075995132.97766262545514231065627511910081109
Variance466.9944789121411.4753301056514657919470144
Observations88dP/dTmaxdP/dTmin..594355969571149
Pearson Correlation0.860833950263616610497701137273831489780123
Hypothesized Mean Difference0365813546504615410057151
df758647210310675
t Stat5.1941347795675879779663
P(T
-
2+ (5*10-3 ) NOS arginase *NOSNO2Arginase** * 2+2.Uric acid* ** ** *
7
10071.860465116373.72093023265.58139534885.581395348811.041009463711.041009463712.297734627812.2977346278
(10-6 )
Ca 2+ (5 * 10-3 M)
%
1
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
NO2-Ca 2+ (5 * 10-3 M) (10-6 )
66.38134.791.61
3.318.520.5
%%100202.9225670383138.008436276
4.971376920813.734224201922.3774697085
4.33.173.09
0.240.350.38
%%10073.720930232671.8604651163
5.581395348811.041009463712.2977346278
0004.97137692084.971376920813.734224201913.734224201922.377469708522.3774697085
Ca 2+ (5 * 10-3 M)
(10-6 )
3
0005.58139534885.581395348811.041009463711.041009463712.297734627812.2977346278
Ca 2+ (5 * 10-3 M)
(10-6 )
1
3.850.890.770.13
2.792.30.530.49
3.892.771.010.97
iNOS
cNOS
/
1
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
NO2- (10-6 )Ca 2+ (5 * 10-3 M)2*- (10-6 )Ca 2+ (5 * 10-3 M)iNOSCa 2+ (5 * 10-3 M)
66.3891.61134.7174.796.1978.923.852.793.89
3.320.518.511.549.121.20.770.531.01
%%100138.008436276202.922567038310055.060103033845.1745850029
4.971376920822.377469708513.73422420196.60560961659.460442873526.8626457172
4.33.093.17. -12.927.577.63cNOS0.892.32.77
0.240.380.351.460.850.70.130.490.97
%%10071.860465116373.720930232610058.591331269359.0557275542
5.581395348812.297734627811.041009463711.300309597511.22853368569.1743119266
100138.008436276202.92256703834.97137692084.971376920813.734224201913.734224201922.377469708522.3774697085
(10-6 )
Ca 2+ (5 * 10-3 M)
3
10071.860465116373.72093023265.58139534885.581395348811.041009463711.041009463712.297734627812.2977346278
(10-6 )
Ca 2+ (5 * 10-3 M)
10058.591331269359.055727554211.300309597511.22853368569.1743119266
(10-6 )
Ca 2+ (5 * 10-3 M)
10055.060103033845.17458500296.60560961659.460442873526.8626457172
(10-6 )
Ca 2+ (5 * 10-3 M)
3.850.890.770.13
2.792.30.530.49
3.892.771.010.97
iNOS
cNOS
/
2
10058.591331269359.055727554211.300309597511.22853368569.1743119266
(10-6 )
Ca 2+ (5 * 10-3 M)
%
1
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
NO2- (10-6 )Ca 2+ (5 * 10-3 M)2*- (10-6 )Ca 2+ (5 * 10-3 M)
66.3891.61134.7174.796.1978.92
3.320.518.511.549.121.2
%%100138.008436276202.922567038310055.060103033845.1745850029
4.971376920822.377469708513.73422420196.60560961659.460442873526.8626457172
4.33.093.17. -12.927.577.63
0.240.380.351.460.850.7
%%10071.860465116373.720930232610058.591331269359.0557275542
5.581395348812.297734627811.041009463711.300309597511.22853368569.1743119266
0004.97137692084.971376920813.734224201913.734224201922.377469708522.3774697085
(10-6 )
Ca 2+ (5 * 10-3 M)
3
0005.58139534885.581395348811.041009463711.041009463712.297734627812.2977346278
(10-6 )
Ca 2+ (5 * 10-3 M)
00011.300309597511.22853368569.1743119266
(10-6 )
Ca 2+ (5 * 10-3 M)
0006.60560961659.460442873526.8626457172
(10-6 )
Ca 2+ (5 * 10-3 M)
4
100138.008436276202.92256703834.97137692084.971376920813.734224201913.734224201922.377469708522.3774697085
(10-6 )
Ca 2+ (5 * 10-3 M)
%
1
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
NO2-Ca 2+ (5 * 10-3 M) (10-6 )
66.38134.791.61
3.318.520.5
%%100202.9225670383138.008436276
4.971376920813.734224201922.3774697085
4.33.173.09
0.240.350.38
%%10073.720930232671.8604651163
5.581395348811.041009463712.2977346278
0004.97137692084.971376920813.734224201913.734224201922.377469708522.3774697085
Ca 2+ (5 * 10-3 M)
(10-6 )
3
0005.58139534885.581395348811.041009463711.041009463712.297734627812.2977346278
Ca 2+ (5 * 10-3 M)
(10-6 )
1
10055.060103033845.17458500296.60560961659.460442873526.8626457172
(10-6 )
Ca 2+ (5 * 10-3 M)
%
1
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
()
1. .
2*- . -NO3-R3NO2-PiiNOScNOSNOSS
30 .//////
M174.712.9251.495.544.366.381.423.850.894.751.67
m11.541.465.130.480.243.30.140.770.130.760.42
n =5
Ca 2+ (5 * 10-3 M)
M78.927.6343.475.033.17134.71.183.892.776.661.78
m21.2*0.7*8.230.350.35*18.5*0.151.010.970.540.15*
t 13.9683.2670.8260.7912.6623.6351.1690.0311.922.0480.246
n =3
(10-6 )
M96.197.5738.083.873.0991.611.212.792.35.11.98
m9.1*0.85*6.950.580.38*20.50.320.530.49*0.430.22
t 25.3463.1161.5522.2182.6921.2150.6011.1332.7810.40.653
n =6
*- (M+/-m)
NO2- (10-6 )Ca 2+ (5 * 10-3 M)2*- (10-6 )Ca 2+ (5 * 10-3 M)
66.3891.61134.7174.796.1978.92
3.320.518.511.549.121.2
%%100138.008436276202.922567038310055.060103033845.1745850029
4.971376920822.377469708513.73422420196.60560961659.460442873526.8626457172
4.33.093.17. -12.927.577.63
0.240.380.351.460.850.7
%%10071.860465116373.720930232610058.591331269359.0557275542
5.581395348812.297734627811.041009463711.300309597511.22853368569.1743119266
0004.97137692084.971376920813.734224201913.734224201922.377469708522.3774697085
(10-6 )
Ca 2+ (5 * 10-3 M)
3
0005.58139534885.581395348811.041009463711.041009463712.297734627812.2977346278
(10-6 )
Ca 2+ (5 * 10-3 M)
00011.300309597511.22853368569.1743119266
(10-6 )
Ca 2+ (5 * 10-3 M)
0006.60560961659.460442873526.8626457172
(10-6 )
Ca 2+ (5 * 10-3 M)
-
NOS
-
Effects NO on heart oxygen consumption
I - L-arginine II - Sodium nitroprusside III - L-NMMA- control- agents
-
c NO-
-
2+ RR (2) CsA (3) 2+ 60 2+ NO
6
000
303240
676480
8884120
9896160
100100100
10085100
936998
8049.898
6536.796
5325.296
3915.294
27894
170520
7560560
0600600
RR
CsA
1
2
3
1
2
3
t, c
[Ca2+]m, %
1
1234123123
05401004600000000
20322872402024405520204151
40851.5494140396675.540446383
60368322960508085.760637694
8008020.3198057.78791.7807379.498
1000871311.5100639096100788098.3
1209287.11206812081
123
0.025
123412340.005
120.3560.250.015
040400.2010.1850.025
2019.4220.10.12430.03
4017.6160.040.08930.035
0.010.06120.04
0.060.04080.045
0.1750.0530.02720.049
0.2350.0130.01460.051
0.2750.0190.00780.055
0.30.0390.00390.05
0.3150.0770.0070.160.025
0.3250.1240.040.02520.2250.005
0.330.1660.010.050.2650.013
0.3350.1920.060.0760.290.024
123450.340.2090.150.040.1050.0370.3050.031
0.110.1120.3430.220.1560.010.1250.0250.3150.038
0.1020.10560.2270.1590.060.150.0190.320.040.015
0.0560.1080.2280.1590.1450.170.0250.0420.01
0.030.09170.1520.190.050.060.015
0.0220.07880.1120.1530.2050.07280.0950.017
0.0220.06830.1040.1530.21750.0770.150.018
0.060.1080.22910.0770.1670.1850.017
0.0550.070.2330.0770.1160.20.015
0.0530.060.1120.240.0850.210.035
0.0510.0550.1080.2430.06210.2150.06
0.0520.1080.0470.2170.085
0.060.0370.105
0.0550.1120.030.12
0.05280.10640.0250.132
0.05130.10760.020.142
0.09710.0190.145
0.0760.01360.15
0.07460.0107
0.07460.0107
1
0000
0000
0000
0000
0000
0000
0000
t,
1
2
3
4
1
2
3
4
2+, %
2
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
A654, %
3
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
520, %
004455
00
00
t1/2,
1
2
1
2
2+
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
,
2+
520,0,05 .
2+
2+
2+
3
,
,
,
1
2
3
4
5
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Ca2+
,
2+
3
654,0,1 .
1
2
3
4
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Sr2+
,
1
2
3
Sr2+
654,0,1 .
3
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1,2,3
A23187
A23187
1- CCCP,2- RR,3- 2+
3
654,0,1.
1
2
1,2
2+ 23187
1231234020401234123
000000000127.517.69.901001001001000000
20131212021.12016.7022413.282087798690200.340.140.09
4024221404231400326.510.8540765872.784400.690.30.2
6036341606138521430.5153.56064396072601.050.450.33
8047.3422807444521528.9142.48054.6264862801.430.620.45
100564221008346532625.2106.6100441736531001.770.810.62
120654331209048532120351027431202.20.980.75
14073433140934953414027721341402.691.160.93
160794441609654416021415261601.331.05
18084444180985441801621220
2008844420010054200120815
2209252208511
240945240636
26096260414
28098280102
30010030000
123
000
403032
806764
1208884
0551609896
2034200100100100
401024010085100
604280936998
80012343208049.898
1234000003606536.796
0100100100100200.160.160.260.224005325.296
2082.6867780400.3850.330.580.544403915.294
4063.868.35658600.710.650.890.9448027894
6044.949.14139801.081.081.171.38520170
803432.53126.41001.431.561.511.665607
100242122191201.71.971.832.126000
1201814161214022.32.22.5
1401391071602.4
16095631802.8
1806322200
2004100
22010
123
12312304.64.6
04.64.604.64.6104.564.38
104.564.38104.564.4204.354.01
204.354.01204.354.02304.113.77
304.113.77304.113.76403.93.533.53
403.93.533.53403.93.51503.673.25
503.673.3503.673.243.24603.433.08
603.433.08603.432.96703.172.8
703.172.8703.172.8802.962.61
802.962.58802.962.53902.732.39
902.73902.731002.532.23
1002.531002.531102.31
1102.311102.311202.11
1202.111202.111301.89
1301.821301.82140
140140
150
160
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
B
RR
1
2
3
t, s
% of total Sr2+
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
4
3
2
RR
A
1
2
3
4
t,
[Ca2+]o,%
0
0
0
0
0
t,
Ca2+,%
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
matrix Me2+ content, %
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
ln A0/A
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
A
k=1,5.10-2 c-1
t1/2=46 c
1
2
3
4
t, s
[Ca2+]m, %
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
B
1
2
3
4
t,s
ln A0/A
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data: N6,7,85.07.05
1
2
3
t, c
ln C
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data:N2, 5.07.05
1
2
3
t, c
ln C
y1 = -0,278x + 4,8947R2 = 0,9953
y2 = -0,229x + 4,6R2 = 0,9899
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
1
2
3
t, c
ln C
00
00
00
1
2
1
2
1
2
1- 2- 2+
5
6
[Ca2+]o,
t1/2, c
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
RR
CsA
1
2
3
2+
1
2
3
t, c
[Ca2+]m, %
12121
010010004.64.603.27
109678.4104.564.38102.98
207855204.354.01202.22
306140304.113.7301.8
404931.4403.93.44401.53
503924503.673.17501.3
603118.9603.43360
702416703.172.8
801913802.962.58
90159902.732.32
1001371002.532.07
1101051102.31
120831202.11
130621301.9
14051140
15030150
1602160
1701
1800
190
200
1231231
0100100100010010010004
108074.3870.47207575.1868.73203.4
205556.0554.33406161.5657.96402.77
304342.6942.58605454.152.58602.2
403432.8233.5780515049.37801.8
502725.4126.541004947.747.241001.4
602219.7921.011204845.8245.72
701615.4816.651404645.2544.59
801312.1613.21604543.71
9099.5710.471804343.01
10077.58.3200
110566.6
12034.75.2
13023.74.1
140133.3
15002.42.6
1601.82.1
1701.51.6
1801.21.3
1900.91121234
20004.64.60100100100100
12204.014.252079.2555442.6
0100100403.53.724050.5343415.3
205570603.083.166028.722215.1
403441802.582.52801913132
6022241001.961.7910013781
8013131201208350
10075.5140513
12033160202
1401018001
1600200
180
1234
0
0.046
0.098
0.1270
0.150.049
0.1640.101
0.1750.138
0.1830.1590
0.1880.1730.027
0.1840.048
0.190.071
0.1930.0850
0.0940.01
0.0980.008
0.1020.011
0.1060.012
0.012
0.012
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t,
[Ca2+m], %
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
ln C
0
0
0
0
0
0
0
1
t, c
ln[C-C2exp(-k2t)]
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
B
1
2
3
t, c
[Ca2+m], %
000
000
000
000
000
000
000
000
000
000
000
1
2
3
t, c
[Ca2+m], %
0
0
0
0
0
0
1
t, c
ln (C-C1)
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
[Ca2+m], %
00
00
00
00
00
00
00
1
2
t, c
ln C
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
2
654,0,1 .
(1)
(2)
(1)
(2)
(1)
(2)
(3)
1
2
3
4
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
2
3
4
t, c
[Ca2+]m, %
1
000
0.0210.0290.001
0.0530.0440.005
0.0750.0530.008
0.0970.060.016
0.1170.0680.021
0.130.0750.029
0.1430.0820.035
0.1530.0880.0471
0.1620.0940.06
0.170.10.066
0.177110.072
0.183120.08
0.188130.087
141414
2+
1
2
3
1-RR2-RR, Ca2+3-Ca2+, RR
1
2
3
t,
[2+]o, .
1
12312300.0070.0170.0340.050.150.41234
0000000011002301100754530100100
10.0210.0290.00110.0240.0260.0022100524047100224.939.460101.4120100
20.0530.0440.00520.050.0480.0023100979592550352082.896.414068
30.0750.0530.00830.0760.0740.004410094939293909016055
40.0970.060.01640.0960.080.00418042
50.1170.0680.02150.1160.0820.00620015
60.130.0750.02960.130.0840.006
70.1430.0820.03570.1420.0860.006
80.1530.0880.047180.1520.0880.008
90.1620.0940.0690.1640.0920.008
100.170.10.066100.1720.0940.008
110.1770.072110.1780.095
120.1830.08120.184
130.1880.087130.188
1414
15
16
1234
00000
10.0210.02800
-6-5.5-5-4.5-4-3.5-3-2.5-6-5.5-5-4.5-4-3.5-320.0410.0440.0030.001
100.0150.0210.040.070.0920.0980.09811004512030.0630.05670.0130.005
200.010.030.0350.0650.0950.09721006545425040.08430.060.0240.009
300.0050.0350.0750.075310097959040050.10080.06660.0370.016
4100939395929060.1170.07370.0470.021
70.130.07790.06240.029
80.14030.08450.0740.035
90.14810.0810.042
100.15450.0880.0517
110.0950.0609
120.1020.0687
130.1090.0765
140.1140.0836
150.1190.088
160.124
170.127
18
1
1001001001001010775555
23529794
0409593
0.034479292
0.05105593
0.150090
1
2
3
4
%
1
2
3
4
2
1001001001001010885566
45659793
12459593
0429095
-454092
-3.50090
%
A540/
1
2
3
1
2
3
lg [M]
-6
-6
-6
-5.5
-5.5
-5.5
-5
-5
-5
-4.5
-4.5
-4.5
-4
-4
-4
-3.5
-3.5
-3.5
-3
-3
-3
-2.5
-2.5
-2.5
0
0.007
0.007
0.006
0.006
0.003
0.003
0.015
0
0.021
0.01
0.04
0.03
0
0.07
0.035
0.005
0.092
0.065
0.035
0.098
0.095
0.075
0.098
0.097
0.075
, %
1
2
3
4
1
2
3
4
lg [M]
3
10024.95
7539.420
456082.8
30101.496.4
1
2
3
,
,%
100
100
68
55
42
15
A654,%
[Ca2+],
0000
0.0210.02800
0.0410.0440.0030.001
0.0630.05670.0130.005
0.08430.060.0240.009
0.10080.06660.0370.016
0.1170.07370.0470.021
0.130.07790.06240.029
0.14030.08450.0740.035
0.148190.0810.042
0.1545100.0880.0517
11110.0950.0609
12120.1020.0687
13130.1090.0765
14140.1140.0836
15150.1190.088
16160.12416
17170.12717
18181818
Ca2+
1
2
3
4
1
2
3
4
t,
A654
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
2+
1
2
3
1-RR2-RR, Ca2+3-Ca2+, RR
1
2
3
t,
[2+]o, .
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
NO-
1
2
3
1
2
3
t,
, ..
2
000
0.0240.0260.002
0.050.0480.002
0.0760.0740.004
0.0960.080.004
0.1160.0820.006
0.130.0840.006
0.1420.0860.006
0.1520.0880.008
0.1640.0920.008
0.1720.0940.008
0.1780.09511
0.1841212
0.1881313
141414
NO-
1
2
3
1-RR2-RR, NO3-NO, RR
1
2
3
t,
[Ca2+]o, .
1
12312300.0070.0170.0340.050.150.41234
0000000011002301100754530100100
10.0210.0290.00110.0240.0260.0022100524047100224.939.460101.4120100
20.0530.0440.00520.050.0480.0023100979592550352082.896.414068
30.0750.0530.00830.0760.0740.004410094939293909016055
40.0970.060.01640.0960.080.00418042
50.1170.0680.02150.1160.0820.00620015
60.130.0750.02960.130.0840.006
70.1430.0820.03570.1420.0860.006
80.1530.0880.047180.1520.0880.008
90.1620.0940.0690.1640.0920.008
100.170.10.066100.1720.0940.008
110.1770.072110.1780.095
120.1830.08120.184
130.1880.087130.188
1414
15
16
1234
00000
10.0210.02800
-6-5.5-5-4.5-4-3.5-3-2.5-6-5.5-5-4.5-4-3.5-320.0410.0440.0030.001
100.0150.0210.040.070.0920.0980.09811004512030.0630.05670.0130.005
200.010.030.0350.0650.0950.09721006545425040.08430.060.0240.009
300.0050.0350.0750.075310097959040050.10080.06660.0370.016
4100939395929060.1170.07370.0470.021
70.130.07790.06240.029
80.14030.08450.0740.035
90.14810.0810.042
100.15450.0880.0517
110.0950.0609
120.1020.0687
130.1090.0765
140.1140.0836
150.1190.088
160.124
170.127
18
1
1001001001001010775555
23529794
0409593
0.034479292
0.05105593
0.150090
1
2
3
4
%
1
2
3
4
2
1001001001001010885566
45659793
12459593
0429095
-454092
-3.50090
%
A540/
1
2
3
1
2
3
lg [M]
-6
-6
-6
-5.5
-5.5
-5.5
-5
-5
-5
-4.5
-4.5
-4.5
-4
-4
-4
-3.5
-3.5
-3.5
-3
-3
-3
-2.5
-2.5
-2.5
0
0.007
0.007
0.006
0.006
0.003
0.003
0.015
0
0.021
0.01
0.04
0.03
0
0.07
0.035
0.005
0.092
0.065
0.035
0.098
0.095
0.075
0.098
0.097
0.075
, %
1
2
3
4
1
2
3
4
lg [M]
3
10024.95
7539.420
456082.8
30101.496.4
1
2
3
,
,%
100
100
68
55
42
15
A654,%
[Ca2+],
0000
0.0210.02800
0.0410.0440.0030.001
0.0630.05670.0130.005
0.08430.060.0240.009
0.10080.06660.0370.016
0.1170.07370.0470.021
0.130.07790.06240.029
0.14030.08450.0740.035
0.148190.0810.042
0.1545100.0880.0517
11110.0950.0609
12120.1020.0687
13130.1090.0765
14140.1140.0836
15150.1190.088
16160.12416
17170.12717
18181818
Ca2+
1
2
3
4
1
2
3
4
t,
A654
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
2+
1
2
3
1-RR2-RR, Ca2+3-Ca2+, RR
1
2
3
t,
[2+]o, .
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
NO-
1
2
3
1-RR2-RR, NO3-NO, RR
NO
1
2
3
t,
[Ca2+]o, .
2
0
0.028
0.044
0.058
0.0668
0.0723
0.078
0.0818
0.085
0.088
Km=50
Km=50
1
[Ca2+],
v, A520.-1
1
12312300.0070.0170.0340.050.150.4123400.020.040.060.080.10.120.140.160.181
0000000011002301100754530100100100.0280.0440.0580.06680.07230.0780.08180.0850.0880.250.1
10.0210.0290.00110.0240.0260.0022100524047100224.939.460101.41201000.50.08
20.0530.0440.00520.050.0480.0023100979592550352082.896.4140680.750.07
30.0750.0530.00830.0760.0740.00441009493929390901605510.06
40.0970.060.01640.0960.080.004180421.250.04
50.1170.0680.02150.1160.0820.006200151.50.038
60.130.0750.02960.130.0840.0061.750.016
70.1430.0820.03570.1420.0860.0062
80.1530.0880.047180.1520.0880.0082.25
90.1620.0940.0690.1640.0920.008
100.170.10.066100.1720.0940.008
110.1770.072110.1780.095
120.1830.08120.184
130.1880.087130.188
1414
15
16
1234
00000
10.0210.02800
-6-5.5-5-4.5-4-3.5-3-2.5-6-5.5-5-4.5-4-3.5-320.0410.0440.0030.001
100.0150.0210.040.070.0920.0980.09811004512030.0630.05670.0130.005
200.010.030.0350.0650.0950.09721006545425040.08430.060.0240.009
300.0050.0350.0750.075310097959040050.10080.06660.0370.016
4100939395929060.1170.07370.0470.021
70.130.07790.06240.029
80.14030.08450.0740.035
90.14810.0810.042
100.15450.0880.0517
110.0950.0609
120.1020.0687
130.1090.0765
140.1140.0836
150.1190.088
160.124
170.127
18
1
00001010775555
0000
0000
0000
0000
0000
1
2
3
4
%
1
2
3
4
2
00001010885566
0000
0000
0000
0000
0000
%
A540/
1
2
3
1
2
3
lg [M]
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0.007
0.007
0.006
0.006
0.003
0.003
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
, %
1
2
3
4
1
2
3
4
lg [M]
3
1
2
3
,
,%
A654,%
[Ca2+],
Ca2+
1
2
3
4
1
2
3
4
t,
A654
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
2+
1
2
3
1-RR2-RR, Ca2+3-Ca2+, RR
1
2
3
t,
[2+]o, .
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
NO-
1
2
3
1-RR2-RR, NO3-NO, RR
NO
1
2
3
t,
[Ca2+]o, .
Km=50
Km=50
1
[Ca2+],
v, A520.-1
0
0
0
0
0
0
0
1
v/[Ca2+], -1.-1
v, A520.-1
-
NO
-
NO NO , ..dP/dt, ../
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
1.8
2
2.2
2.4
0
25
50
75
-1000
0
1000
2000
-
- bax 1 - 2 - 1 , 2 5 , 3 40 bax, 487 .. M 1 1 2 2 3 3 M 1 1 2 2 3 3
-
2+ 1, 3 - ; 2, 4 -
-
2+ - - 1 ; 2
-
2-, H2O2 2-H2O21 - 2 -
-
NOS 2+- 1, 2 - ; 3, 4 - L-NAME+2+L-NAME+-Na+2+2+
-
- 1 2 (10-5/); 3 (10-5/), (10-5/).
-
22, 2- .
1 2 22.2-
1
5.560.471.95
23.759.183.93
/
Sheet1
5.560.47
23.753.93
9.181.95
1.180.22
3.690.81
1.170.09
23.753.93
5.560.47
Sheet1
0
0
0
0
/
Sheet2
00
0
Sheet3
000.471.95
003.93
/
000.220.09
000.81
*10(-2)/30*
2
1.180.220.09
3.691.170.81
*10(-2)/30*
Sheet1
5.560.47
23.753.93
9.181.95
1.180.22
3.690.81
1.170.09
23.753.93
5.560.47
Sheet1
0
0
0
0
/
Sheet2
00
0
Sheet3
000.471.95
003.93
/
000.220.09
000.81
*10(-2)/30*
-
1 - 2 - dP/dt1212
-
2+ - 2+ + 2+
-
- bax NO- 1 2 3 4 1 2 3 4487 .. bax
-
6-
( 90%) -
1 control
(n=197)
2 hypoxia, precondition, 1 month (n=7)
5 trolox intraperitaneal (10 + 5 mg/kg) (n=25)
3 - hypoxia, postcondition, 3 days (n=12)
6 trolox per os (10 mg/kg)
(n=35)
4 - hypoxia, pre- and postcondition (n=16)
7 melatonine intraperitaneal (10 mg/kg) (n=12)
_1197974617.bin
-
1
0.080.0180.018
0.2150.0250.025
0.280.030.03
0.2650.040.04
0.350.050.05
D
1
Control0.080.0180.018
10 min0.2150.0250.025
90 min0.280.030.03
2 min0.2650.040.04
5 min0.350.050.05
1
0
0
0
0
0
0
0
D
D
2
3
2
0.9656482075
0.9201371873
0.8450224979
0.8059033412
coefficient of correlation, r
1
Control0.080.0180.018
10 min0.2150.0250.025
90 min0.280.030.03
2 min0.2650.040.04
5 min0.350.050.05
1
00.0180.018
0
00.0250.025
00.030.03
0
00.040.04
00.050.05
artificial circulation
reperfusion
D
4
0.0650.0043301270.004330127
0.1450.0350.035
Sex
Source value
1
0.8586157594
0.8256644514
0.813253534
coefficient of correlation, r
2
.Male0.0650.0043301270.004330127
.Feminine0.1450.0350.035
400.30428571430.04512373660.0451237366
310.59
330.58
370.52
510.23
530.52
550.36
570.22
590.41
600.23
660.16
Sex0.8586157594
Age0.8256644514
ECG0.813253534
CPK0.9656482075
mvCPK0.9201371873
AST0.8450224979
LDG0.8059033412
2
0
0
0
0
coefficient of correlation, r
3
3
0.550.01784708710.0178470871
0.30428571430.04512373660.0451237366
AGE
Max. value
-
/ 1 2 -
(150 /) (210-5/)
- - 1 - 2 - 3 - l - NAME4 - t(BOOH)5 -6 - +7 - + l-* - p
-
1 - 2 - 3 - l - NAME 4 - t(BOOH)5 - 6 - + 7 - + l-
-
` (10-12 ) (1012 )` (1012 ) L-
-
( , dP/dt max, dP/dt min)
( , dP/dt max, dP/dt min)
2+, , t-BuOOH 2+, a mt-NOS NO a mt-NOS NO
(22;2-) () (22;2-) () m- bax m- bax
-
2+ m 2+ 23187 - 2+ 1 CCCP; 2 CCCP, CsA; 3 . CCCP (1); CCCP, RR (2, 4); CsA, RR, CCCP (3). 2+ (1) 2+ (2)
3
0000
21.12016.70
4231400
6138521
7444521
8346532
9048532
9349534
96160544
98180544
10020054200
1
4
3
2
RR
A
1
2
3
4
t,
[Ca2+]o,%
1
1234123123
05401004600000000
20322872402024405520204151
40851.5494140396675.540446383
60368322960508085.760637694
8008020.3198057.78791.7807379.498
1000871311.5100639096100788098.3
1209287.11206812081
123
0.025
123412340.005
120.3560.250.015
040400.2010.1850.025
2019.4220.10.12430.03
4017.6160.040.08930.035
0.010.06120.04
0.060.04080.045
0.1750.0530.02720.049
0.2350.0130.01460.051
0.2750.0190.00780.055
0.30.0390.00390.05
0.3150.0770.0070.160.025
0.3250.1240.040.02520.2250.005
0.330.1660.010.050.2650.013
0.3350.1920.060.0760.290.024
123450.340.2090.150.040.1050.0370.3050.031
0.110.1120.3430.220.1560.010.1250.0250.3150.038
0.1020.10560.2270.1590.060.150.0190.320.040.015
0.0560.1080.2280.1590.1450.170.0250.0420.01
0.030.09170.1520.190.050.060.015
0.0220.07880.1120.1530.2050.07280.0950.017
0.0220.06830.1040.1530.21750.0770.150.018
0.060.1080.22910.0770.1670.1850.017
0.0550.070.2330.0770.1160.20.015
0.0530.060.1120.240.0850.210.035
0.0510.0550.1080.2430.06210.2150.06
0.0520.1080.0470.2170.085
0.060.0370.105
0.0550.1120.030.12
0.05280.10640.0250.132
0.05130.10760.020.142
0.09710.0190.145
0.0760.01360.15
0.07460.0107
0.07460.0107
1
0000
0000
0000
0000
0000
0000
0000
t,
1
2
3
4
1
2
3
4
2+, %
2
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
A654, %
3
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
520, %
004455
00
00
t1/2,
1
2
1
2
2+
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
,
2+
520,0,05 .
2+
2+
2+
3
,
,
,
1
2
3
4
5
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Ca2+
,
2+
3
654,0,1 .
1
2
3
4
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Sr2+
,
1
2
3
Sr2+
654,0,1 .
3
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
1
2
3
2
3
A23187
A23187
A23187
1- CCCP,2- RR,3- 2+
3
654,0,1 .
1
2
3
1
1231234020401234123
000000000127.517.69.901001001001000000
20131212021.12016.7022413.282087798690200.340.140.09
4024221404231400326.510.8540765872.784400.690.30.2
6036341606138521430.5153.56064396072601.050.450.33
8047.3422807444521528.9142.48054.6264862801.430.620.45
100564221008346532625.2106.6100441736531001.770.810.62
120654331209048532120351027431202.20.980.75
14073433140934953414027721341402.691.160.93
160794441609654416021415261601.331.05
18084444180985441801621220
2008844420010054200120815
2209252208511
240945240636
26096260414
28098280102
30010030000
055
2034
4010
604
8001234
123400000
0100100100100200.160.160.260.22
2082.6867780400.3850.330.580.54
4063.868.35658600.710.650.890.94
6044.949.14139801.081.081.171.38
803432.53126.41001.431.561.511.66
100242122191201.71.971.832.12
1201814161214022.32.22.5
1401391071602.4
16095631802.8
1806322200
2004100
22010
123
12312304.64.6
04.64.604.64.6104.564.38
104.564.38104.564.4204.354.01
204.354.01204.354.02304.113.77
304.113.77304.113.76403.93.533.53
403.93.533.53403.93.51503.673.25
503.673.3503.673.243.24603.433.08
603.433.08603.432.96703.172.8
703.172.8703.172.8802.962.61
802.962.58802.962.53902.732.39
902.73902.731002.532.23
1002.531002.531102.31
1102.311102.311202.11
1202.111202.111301.89
1301.821301.82140
140140
150
160
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
B
RR
1
2
3
t, s
% of total Sr2+
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
4
3
2
RR
A
1
2
3
4
t,
[Ca2+]o,%
0
0
0
0
0
t,
Ca2+,%
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
matrix Me2+ content, %
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
ln A0/A
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
A
k=1,5.10-2 c-1
t1/2=46 c
1
2
3
4
t, s
[Ca2+]m, %
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
B
1
2
3
4
t,s
ln A0/A
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data: N6,7,85.07.05
1
2
3
t, c
ln C
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data:N2, 5.07.05
1
2
3
t, c
ln C
y1 = -0,278x + 4,8947R2 = 0,9953
y2 = -0,229x + 4,6R2 = 0,9899
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
1
2
3
t, c
ln C
00
00
00
1
2
1
2
1
2
1- 2- 2+
5
6
[Ca2+]o,
t1/2, c
12121
010010004.64.603.27
109678.4104.564.38102.98
207855204.354.01202.22
306140304.113.7301.8
404931.4403.93.44401.53
503924503.673.17501.3
603118.9603.43360
702416703.172.8
801913802.962.58
90159902.732.32
1001371002.532.07
1101051102.31
120831202.11
130621301.9
14051140
15030150
1602160
1701
1800
190
200
1231231
0100100100010010010004
108074.3870.47207575.1868.73203.4
205556.0554.33406161.5657.96402.77
304342.6942.58605454.152.58602.2
403432.8233.5780515049.37801.8
502725.4126.541004947.747.241001.4
602219.7921.011204845.8245.72
701615.4816.651404645.2544.59
801312.1613.21604543.71
9099.5710.471804343.01
10077.58.3200
110566.6
12034.75.2
13023.74.1
140133.3
15002.42.6
1601.82.1
1701.51.6
1801.21.3
1900.91121234
20004.64.60100100100100
12204.014.252079.2555442.6
0100100403.53.724050.5343415.3
205570603.083.166028.722215.1
403441802.582.52801913132
6022241001.961.7910013781
8013131201208350
10075.5140513
12033160202
1401018001
1600200
180
1234
0
0.046
0.098
0.1270
0.150.049
0.1640.101
0.1750.138
0.1830.1590
0.1880.1730.027
0.1840.048
0.190.071
0.1930.0850
0.0940.01
0.0980.008
0.1020.011
0.1060.012
0.012
0.012
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t,
[Ca2+m], %
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
ln C
0
0
0
0
0
0
0
1
t, c
ln[C-C2exp(-k2t)]
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
B
1
2
3
t, c
[Ca2+m], %
000
000
000
000
000
000
000
000
000
000
000
1
2
3
t, c
[Ca2+m], %
0
0
0
0
0
0
1
t, c
ln (C-C1)
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
[Ca2+m], %
00
00
00
00
00
00
00
1
2
t, c
ln C
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
2
654,0,1 .
(1)
(2)
(1)
(2)
(1)
(2)
(3)
1
2
3
4
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
2
3
4
t, c
[Ca2+]m, %
1
0.025
0.005
0.015
0.025
0.03
0.035
0.04
0.045
0.049
0.051
0.055
0.05
0.160.025
0.2250.005
0.2650.013
0.290.024
0.3050.031
0.3150.038
0.320.04
0.042
0.06
0.095
0.15
0.185
0.2
0.21
0.215
0.217
1,2,3
A23187
A23187
1- CCCP,2- RR,3- 2+
3
654,0,1.
1
2
1,2
1
1234123123
05401004600000000
20322872402024405520204151
40851.5494140396675.540446383
60368322960508085.760637694
8008020.3198057.78791.7807379.498
1000871311.5100639096100788098.3
1209287.11206812081
123
0.025
123412340.005
120.3560.250.015
040400.2010.1850.025
2019.4220.10.12430.03
4017.6160.040.08930.035
0.010.06120.04
0.060.04080.045
0.1750.0530.02720.049
0.2350.0130.01460.051
0.2750.0190.00780.055
0.30.0390.00390.05
0.3150.0770.0070.160.025
0.3250.1240.040.02520.2250.005
0.330.1660.010.050.2650.013
0.3350.1920.060.0760.290.024
123450.340.2090.150.040.1050.0370.3050.031
0.110.1120.3430.220.1560.010.1250.0250.3150.038
0.1020.10560.2270.1590.060.150.0190.320.040.015
0.0560.1080.2280.1590.1450.170.0250.0420.01
0.030.09170.1520.190.050.060.015
0.0220.07880.1120.1530.2050.07280.0950.017
0.0220.06830.1040.1530.21750.0770.150.018
0.060.1080.22910.0770.1670.1850.017
0.0550.070.2330.0770.1160.20.015
0.0530.060.1120.240.0850.210.035
0.0510.0550.1080.2430.06210.2150.06
0.0520.1080.0470.2170.085
0.060.0370.105
0.0550.1120.030.12
0.05280.10640.0250.132
0.05130.10760.020.142
0.09710.0190.145
0.0760.01360.15
0.07460.0107
0.07460.0107
1
0000
0000
0000
0000
0000
0000
0000
t,
1
2
3
4
1
2
3
4
2+, %
2
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
A654, %
3
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
520, %
004455
00
00
t1/2,
1
2
1
2
2+
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
,
2+
520,0,05 .
2+
2+
2+
3
,
,
,
1
2
3
4
5
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Ca2+
,
2+
3
654,0,1 .
1
2
3
4
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Sr2+
,
1
2
3
Sr2+
654,0,1 .
3
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1,2,3
A23187
A23187
1- CCCP,2- RR,3- 2+
3
654,0,1.
1
2
1,2
2+ 23187
1231234020401234123
000000000127.517.69.901001001001000000
20131212021.12016.7022413.282087798690200.340.140.09
4024221404231400326.510.8540765872.784400.690.30.2
6036341606138521430.5153.56064396072601.050.450.33
8047.3422807444521528.9142.48054.6264862801.430.620.45
100564221008346532625.2106.6100441736531001.770.810.62
120654331209048532120351027431202.20.980.75
14073433140934953414027721341402.691.160.93
160794441609654416021415261601.331.05
18084444180985441801621220
2008844420010054200120815
2209252208511
240945240636
26096260414
28098280102
30010030000
123
000
403032
806764
1208884
0551609896
2034200100100100
401024010085100
604280936998
80012343208049.898
1234000003606536.796
0100100100100200.160.160.260.224005325.296
2082.6867780400.3850.330.580.544403915.294
4063.868.35658600.710.650.890.9448027894
6044.949.14139801.081.081.171.38520170
803432.53126.41001.431.561.511.665607
100242122191201.71.971.832.126000
1201814161214022.32.22.5
1401391071602.4
16095631802.8
1806322200
2004100
22010
123
12312304.64.6
04.64.604.64.6104.564.38
104.564.38104.564.4204.354.01
204.354.01204.354.02304.113.77
304.113.77304.113.76403.93.533.53
403.93.533.53403.93.51503.673.25
503.673.3503.673.243.24603.433.08
603.433.08603.432.96703.172.8
703.172.8703.172.8802.962.61
802.962.58802.962.53902.732.39
902.73902.731002.532.23
1002.531002.531102.31
1102.311102.311202.11
1202.111202.111301.89
1301.821301.82140
140140
150
160
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
B
RR
1
2
3
t, s
% of total Sr2+
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
4
3
2
RR
A
1
2
3
4
t,
[Ca2+]o,%
0
0
0
0
0
t,
Ca2+,%
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
matrix Me2+ content, %
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
ln A0/A
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
A
k=1,5.10-2 c-1
t1/2=46 c
1
2
3
4
t, s
[Ca2+]m, %
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
B
1
2
3
4
t,s
ln A0/A
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data: N6,7,85.07.05
1
2
3
t, c
ln C
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data:N2, 5.07.05
1
2
3
t, c
ln C
y1 = -0,278x + 4,8947R2 = 0,9953
y2 = -0,229x + 4,6R2 = 0,9899
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
1
2
3
t, c
ln C
00
00
00
1
2
1
2
1
2
1- 2- 2+
5
6
[Ca2+]o,
t1/2, c
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
RR
CsA
1
2
3
2+
1
2
3
t, c
[Ca2+]m, %
12121
010010004.64.603.27
109678.4104.564.38102.98
207855204.354.01202.22
306140304.113.7301.8
404931.4403.93.44401.53
503924503.673.17501.3
603118.9603.43360
702416703.172.8
801913802.962.58
90159902.732.32
1001371002.532.07
1101051102.31
120831202.11
130621301.9
14051140
15030150
1602160
1701
1800
190
200
1231231
0100100100010010010004
108074.3870.47207575.1868.73203.4
205556.0554.33406161.5657.96402.77
304342.6942.58605454.152.58602.2
403432.8233.5780515049.37801.8
502725.4126.541004947.747.241001.4
602219.7921.011204845.8245.72
701615.4816.651404645.2544.59
801312.1613.21604543.71
9099.5710.471804343.01
10077.58.3200
110566.6
12034.75.2
13023.74.1
140133.3
15002.42.6
1601.82.1
1701.51.6
1801.21.3
1900.91121234
20004.64.60100100100100
12204.014.252079.2555442.6
0100100403.53.724050.5343415.3
205570603.083.166028.722215.1
403441802.582.52801913132
6022241001.961.7910013781
8013131201208350
10075.5140513
12033160202
1401018001
1600200
180
1234
0
0.046
0.098
0.1270
0.150.049
0.1640.101
0.1750.138
0.1830.1590
0.1880.1730.027
0.1840.048
0.190.071
0.1930.0850
0.0940.01
0.0980.008
0.1020.011
0.1060.012
0.012
0.012
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t,
[Ca2+m], %
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
ln C
0
0
0
0
0
0
0
1
t, c
ln[C-C2exp(-k2t)]
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
B
1
2
3
t, c
[Ca2+m], %
000
000
000
000
000
000
000
000
000
000
000
1
2
3
t, c
[Ca2+m], %
0
0
0
0
0
0
1
t, c
ln (C-C1)
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
[Ca2+m], %
00
00
00
00
00
00
00
1
2
t, c
ln C
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
2
654,0,1 .
(1)
(2)
(1)
(2)
(1)
(2)
(3)
1
2
3
4
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
2
3
4
t, c
[Ca2+]m, %
4
28.925.2
1410
2.46.6
1
2
1
2
1
2
1- 2- 2+
5
6
[Ca2+]o,
t1/2, c
1
1234123123
05401004600000000
20322872402024405520204151
40851.5494140396675.540446383
60368322960508085.760637694
8008020.3198057.78791.7807379.498
1000871311.5100639096100788098.3
1209287.11206812081
123
0.025
123412340.005
120.3560.250.015
040400.2010.1850.025
2019.4220.10.12430.03
4017.6160.040.08930.035
0.010.06120.04
0.060.04080.045
0.1750.0530.02720.049
0.2350.0130.01460.051
0.2750.0190.00780.055
0.30.0390.00390.05
0.3150.0770.0070.160.025
0.3250.1240.040.02520.2250.005
0.330.1660.010.050.2650.013
0.3350.1920.060.0760.290.024
123450.340.2090.150.040.1050.0370.3050.031
0.110.1120.3430.220.1560.010.1250.0250.3150.038
0.1020.10560.2270.1590.060.150.0190.320.040.015
0.0560.1080.2280.1590.1450.170.0250.0420.01
0.030.09170.1520.190.050.060.015
0.0220.07880.1120.1530.2050.07280.0950.017
0.0220.06830.1040.1530.21750.0770.150.018
0.060.1080.22910.0770.1670.1850.017
0.0550.070.2330.0770.1160.20.015
0.0530.060.1120.240.0850.210.035
0.0510.0550.1080.2430.06210.2150.06
0.0520.1080.0470.2170.085
0.060.0370.105
0.0550.1120.030.12
0.05280.10640.0250.132
0.05130.10760.020.142
0.09710.0190.145
0.0760.01360.15
0.07460.0107
0.07460.0107
1
0000
0000
0000
0000
0000
0000
0000
t,
1
2
3
4
1
2
3
4
2+, %
2
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
A654, %
3
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
520, %
004455
00
00
t1/2,
1
2
1
2
2+
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
,
2+
520,0,05 .
2+
2+
2+
3
,
,
,
1
2
3
4
5
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Ca2+
,
2+
3
654,0,1 .
1
2
3
4
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Sr2+
,
1
2
3
Sr2+
654,0,1 .
3
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
1
2
3
2
3
A23187
A23187
A23187
1- CCCP,2- RR,3- 2+
3
654,0,1 .
1
2
3
1
1231234020401234123
000000000127.517.69.901001001001000000
20131212021.12016.7022413.282087798690200.340.140.09
4024221404231400326.510.8540765872.784400.690.30.2
6036341606138521430.5153.56064396072601.050.450.33
8047.3422807444521528.9142.48054.6264862801.430.620.45
100564221008346532625.2106.6100441736531001.770.810.62
120654331209048532120351027431202.20.980.75
14073433140934953414027721341402.691.160.93
160794441609654416021415261601.331.05
18084444180985441801621220
2008844420010054200120815
2209252208511
240945240636
26096260414
28098280102
30010030000
055
2034
4010
604
8001234
123400000
0100100100100200.160.160.260.22
2082.6867780400.3850.330.580.54
4063.868.35658600.710.650.890.94
6044.949.14139801.081.081.171.38
803432.53126.41001.431.561.511.66
100242122191201.71.971.832.12
1201814161214022.32.22.5
1401391071602.4
16095631802.8
1806322200
2004100
22010
123
12312304.64.6
04.64.604.64.6104.564.38
104.564.38104.564.4204.354.01
204.354.01204.354.02304.113.77
304.113.77304.113.76403.93.533.53
403.93.533.53403.93.51503.673.25
503.673.3503.673.243.24603.433.08
603.433.08603.432.96703.172.8
703.172.8703.172.8802.962.61
802.962.58802.962.53902.732.39
902.73902.731002.532.23
1002.531002.531102.31
1102.311102.311202.11
1202.111202.111301.89
1301.821301.82140
140140
150
160
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
B
RR
1
2
3
t, s
% of total Sr2+
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
4
3
2
RR
A
1
2
3
4
t,
[Ca2+]o,%
0
0
0
0
0
t,
Ca2+,%
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
matrix Me2+ content, %
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
ln A0/A
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
A
k=1,5.10-2 c-1
t1/2=46 c
1
2
3
4
t, s
[Ca2+]m, %
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
B
1
2
3
4
t,s
ln A0/A
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data: N6,7,85.07.05
1
2
3
t, c
ln C
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data:N2, 5.07.05
1
2
3
t, c
ln C
y1 = -0,278x + 4,8947R2 = 0,9953
y2 = -0,229x + 4,6R2 = 0,9899
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
1
2
3
t, c
ln C
00
00
00
1
2
1
2
1
2
1- 2- 2+
5
6
[Ca2+]o,
t1/2, c
12121
010010004.64.603.27
109678.4104.564.38102.98
207855204.354.01202.22
306140304.113.7301.8
404931.4403.93.44401.53
503924503.673.17501.3
603118.9603.43360
702416703.172.8
801913802.962.58
90159902.732.32
1001371002.532.07
1101051102.31
120831202.11
130621301.9
14051140
15030150
1602160
1701
1800
190
200
1231231
0100100100010010010004
108074.3870.47207575.1868.73203.4
205556.0554.33406161.5657.96402.77
304342.6942.58605454.152.58602.2
403432.8233.5780515049.37801.8
502725.4126.541004947.747.241001.4
602219.7921.011204845.8245.72
701615.4816.651404645.2544.59
801312.1613.21604543.71
9099.5710.471804343.01
10077.58.3200
110566.6
12034.75.2
13023.74.1
140133.3
15002.42.6
1601.82.1
1701.51.6
1801.21.3
1900.91121234
20004.64.60100100100100
12204.014.252079.2555442.6
0100100403.53.724050.5343415.3
205570603.083.166028.722215.1
403441802.582.52801913132
6022241001.961.7910013781
8013131201208350
10075.5140513
12033160202
1401018001
1600200
180
1234
0
0.046
0.098
0.1270
0.150.049
0.1640.101
0.1750.138
0.1830.1590
0.1880.1730.027
0.1840.048
0.190.071
0.1930.0850
0.0940.01
0.0980.008
0.1020.011
0.1060.012
0.012
0.012
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t,
[Ca2+m], %
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
ln C
0
0
0
0
0
0
0
1
t, c
ln[C-C2exp(-k2t)]
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
B
1
2
3
t, c
[Ca2+m], %
000
000
000
000
000
000
000
000
000
000
000
1
2
3
t, c
[Ca2+m], %
0
0
0
0
0
0
1
t, c
ln (C-C1)
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
[Ca2+m], %
00
00
00
00
00
00
00
1
2
t, c
ln C
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
2
654,0,1 .
(1)
(2)
(1)
(2)
(1)
(2)
(3)
1
2
3
4
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
2
3
4
t, c
[Ca2+]m, %
1
100100100100
76555442.6
47.7343418.3
28.722217.3
1913132
13781
8350
513140
202160
01801180
200200200200
1
2
3
4
t, c
[Ca2+]m, %
1
1234123123
05401004600000000
20322872402024405520204151
40851.5494140396675.540446383
60368322960508085.760637694
8008020.3198057.78791.7807379.498
1000871311.5100639096100788098.3
1209287.11206812081
123
0.025
123412340.005
120.3560.250.015
040400.2010.1850.025
2019.4220.10.12430.03
4017.6160.040.08930.035
0.010.06120.04
0.060.04080.045
0.1750.0530.02720.049
0.2350.0130.01460.051
0.2750.0190.00780.055
0.30.0390.00390.05
0.3150.0770.0070.160.025
0.3250.1240.040.02520.2250.005
0.330.1660.010.050.2650.013
0.3350.1920.060.0760.290.024
123450.340.2090.150.040.1050.0370.3050.031
0.110.1120.3430.220.1560.010.1250.0250.3150.038
0.1020.10560.2270.1590.060.150.0190.320.040.015
0.0560.1080.2280.1590.1450.170.0250.0420.01
0.030.09170.1520.190.050.060.015
0.0220.07880.1120.1530.2050.07280.0950.017
0.0220.06830.1040.1530.21750.0770.150.018
0.060.1080.22910.0770.1670.1850.017
0.0550.070.2330.0770.1160.20.015
0.0530.060.1120.240.0850.210.035
0.0510.0550.1080.2430.06210.2150.06
0.0520.1080.0470.2170.085
0.060.0370.105
0.0550.1120.030.12
0.05280.10640.0250.132
0.05130.10760.020.142
0.09710.0190.145
0.0760.01360.15
0.07460.0107
0.07460.0107
1
0000
0000
0000
0000
0000
0000
0000
t,
1
2
3
4
1
2
3
4
2+, %
2
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
A654, %
3
000
000
000
000
000
000
000
t,
1
2
3
1
2
3
520, %
004455
00
00
t1/2,
1
2
1
2
2+
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
,
2+
520,0,05 .
2+
2+
2+
3
,
,
,
1
2
3
4
5
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Ca2+
,
2+
3
654,0,1 .
1
2
3
4
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Sr2+
,
1
2
3
Sr2+
654,0,1 .
3
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1,2,3
A23187
A23187
1- CCCP,2- RR,3- 2+
3
654,0,1.
1
2
1,2
2+ 23187
1231234020401234123
000000000127.517.69.901001001001000000
20131212021.12016.7022413.282087798690200.340.140.09
4024221404231400326.510.8540765872.784400.690.30.2
6036341606138521430.5153.56064396072601.050.450.33
8047.3422807444521528.9142.48054.6264862801.430.620.45
100564221008346532625.2106.6100441736531001.770.810.62
120654331209048532120351027431202.20.980.75
14073433140934953414027721341402.691.160.93
160794441609654416021415261601.331.05
18084444180985441801621220
2008844420010054200120815
2209252208511
240945240636
26096260414
28098280102
30010030000
123
000
403032
806764
1208884
0551609896
2034200100100100
401024010085100
604280936998
80012343208049.898
1234000003606536.796
0100100100100200.160.160.260.224005325.296
2082.6867780400.3850.330.580.544403915.294
4063.868.35658600.710.650.890.9448027894
6044.949.14139801.081.081.171.38520170
803432.53126.41001.431.561.511.665607
100242122191201.71.971.832.126000
1201814161214022.32.22.5
1401391071602.4
16095631802.8
1806322200
2004100
22010
123
12312304.64.6
04.64.604.64.6104.564.38
104.564.38104.564.4204.354.01
204.354.01204.354.02304.113.77
304.113.77304.113.76403.93.533.53
403.93.533.53403.93.51503.673.25
503.673.3503.673.243.24603.433.08
603.433.08603.432.96703.172.8
703.172.8703.172.8802.962.61
802.962.58802.962.53902.732.39
902.73902.731002.532.23
1002.531002.531102.31
1102.311102.311202.11
1202.111202.111301.89
1301.821301.82140
140140
150
160
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
B
RR
1
2
3
t, s
% of total Sr2+
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
1
4
3
2
RR
A
1
2
3
4
t,
[Ca2+]o,%
0
0
0
0
0
t,
Ca2+,%
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
matrix Me2+ content, %
000
000
000
000
000
000
000
000
000
1
2
3
1
2
3
t, s
ln A0/A
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
A
k=1,5.10-2 c-1
t1/2=46 c
1
2
3
4
t, s
[Ca2+]m, %
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
B
1
2
3
4
t,s
ln A0/A
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data: N6,7,85.07.05
1
2
3
t, c
ln C
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
data:N2, 5.07.05
1
2
3
t, c
ln C
y1 = -0,278x + 4,8947R2 = 0,9953
y2 = -0,229x + 4,6R2 = 0,9899
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
1
2
1
2
3
t, c
ln C
00
00
00
1
2
1
2
1
2
1- 2- 2+
5
6
[Ca2+]o,
t1/2, c
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
RR
CsA
1
2
3
2+
1
2
3
t, c
[Ca2+]m, %
12121
010010004.64.603.27
109678.4104.564.38102.98
207855204.354.01202.22
306140304.113.7301.8
404931.4403.93.44401.53
503924503.673.17501.3
603118.9603.43360
702416703.172.8
801913802.962.58
90159902.732.32
1001371002.532.07
1101051102.31
120831202.11
130621301.9
14051140
15030150
1602160
1701
1800
190
200
1231231
0100100100010010010004
108074.3870.47207575.1868.73203.4
205556.0554.33406161.5657.96402.77
304342.6942.58605454.152.58602.2
403432.8233.5780515049.37801.8
502725.4126.541004947.747.241001.4
602219.7921.011204845.8245.72
701615.4816.651404645.2544.59
801312.1613.21604543.71
9099.5710.471804343.01
10077.58.3200
110566.6
12034.75.2
13023.74.1
140133.3
15002.42.6
1601.82.1
1701.51.6
1801.21.3
1900.91121234
20004.64.60100100100100
12204.014.252076555442.6
0100100403.53.724047.7343418.3
205570603.083.166028.722217.3
403441802.582.52801913132
6022241001.961.7910013781
8013131201208350
10075.5140513
12033160202
1401018001
1600200
180
1234
0
0.046
0.098
0.1270
0.150.049
0.1640.101
0.1750.138
0.1830.1590
0.1880.1730.027
0.1840.048
0.190.071
0.1930.0850
0.0940.01
0.0980.008
0.1020.011
0.1060.012
0.012
0.012
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t,
[Ca2+m], %
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
1
2
1
2
t, c
ln C
0
0
0
0
0
0
0
1
t, c
ln[C-C2e